University of Edinburgh/BHF Centre for Cardiovascular Science
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Clinical Mass Spectrometry
A collection for research data produced at the Edinburgh Clinical Research Facility Mass Spectrometry Core -
Edinburgh Kidney Research Group
Our objective is to improve cardiovascular outcomes for people living with kidney disease -
Metabolism, Obesity and Diabetes (MOD)
The MOD group brings together clinical and basic scientists with an interest in the physiology and pathophysiology of metabolic processes relevant to obesity, diabetes and cardiovascular disease. -
PiW
PET (Positron Emission Tomography) is Wonderful
Recent Submissions
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P2X7 Receptor Knockout Does Not Alter Renal Function or Prevent Angiotensin II-Induced Kidney Injury in F344 Rats
P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic ... -
[18F]LW223 has low non-displaceable binding in murine brain, enabling high sensitivity TSPO PET imaging
Neuroinflammation is associated with a number of brain diseases, making it a common feature of cerebral pathology. Among the best-known biomarkers for neuroinflammation in Positron Emission Tomography (PET) research is ... -
Sexually dimorphic murine brain uptake of the 18 kDa translocator protein PET radiotracer [18F]LW223
The 18 kDa translocator protein is a well-known biomarker of neuroinflammation, but also plays a role in homeostasis. PET with 18 kDa translocator protein radiotracers [11C]PBR28 in humans and [18F]GE180 in mice has ... -
Analysis of AT7519 and acetaminophen in a mouse model of acute inflammation by LC-MS/MS
This dataset is the LC-MS/MS analysis of quantities of acetaminophen (APAP) and the drug AT7519 in a preclinical study, as described. Neutrophils are crucial innate immune cells required for host pathogen defense, with ... -
First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses
Datasets for manuscript published in Nature Nanotechnology. Graphene oxide nanomaterials are being developed for wide-ranging applications, but have potential safety concerns for human health. We conducted a double-blind ... -
Development of a UPLC-MS/MS method for the simultaneous analysis of AT7519 and acetaminophen in a mouse model of acute inflammation
Targeted chromatography and mass spectrometry can be used to assess multiple compounds simultaneously and this approach has not been applied yet to measure APAP and AT7519 in a mouse model.Targeted mass spectrometry ... -
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
These are the source data and code underlying the figures presented in the updated version of this preprint https://doi.org/10.1101/2022.02.20.481222. For further details please see the file named readme_Sex_Differences_ ... -
SUPERSEDED - Dataset: The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
## This item has been replaced by the one which can be found at https://datashare.ed.ac.uk/handle/10283/4810 - https://doi.org/10.7488/ds/3817 ##. These are the source data and code underlying the figures presented in ... -
Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism
Myocardial infarction (MI) is one of the leading causes of death worldwide, and inflammation is central to tissue response and patient outcomes. The 18-kDa translocator protein (TSPO) has been used in PET as an inflammatory ... -
Effects of administration route on uptake kinetics of 18F‑sodium fluoride positron emission tomography in mice
18F-sodium fluoride (18F-NaF) is a positron emission tomography (PET) radiotracer widely used in skeletal imaging and has also been proposed as a biomarker of active calcification in atherosclerosis. Like most PET radiotracers, ... -
Cawthorn Lab: Data for sex differences manuscript
*an updated version of this item can be found at https://doi.org/10.7488/ds/3758* Source data for figures included in our manuscript about age-dependent sex differences in the metabolic effects of caloric restriction ... -
Dynamic Compartmentalisation of Intracellular Sodium in collecting duct cells
Movie S1.avi - shows localised release of sodium green from a vesicle; Movie S2.avi - shows decrease in fluorescence of vesicle over time; Movie S3.mp4 - shows increase in fluorescence of one vesicle with decrease ... -
A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo
Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level ... -
PET Imaging experimental dataset - Victoria Morley
Data generated by Victoria Morley as part of her PhD research -
scRNA transcription profile of adult zebrafish podocytes
Background/Aims: The role of podocytes is well conserved across species from drosophila to teleosts, and mammals. Identifying the molecular markers that actively maintain the integrity of the podocyte will enable a greater ... -
Loss of Adam10 disrupts ion transport in immortalised kidney collecting duct cells
The kidney cortical collecting duct (CCD) comprises of principal cells (PC), intercalated cells (IC) and the recently discovered intermediate cell type. Kidney pathology in a mouse model of the syndrome of apparent aldosterone ... -
Average male and female mouse brain TSPO atlases, generated using TSPO PET radiotracer [18F]LW223 (normalised to injected dose)
[18F]LW223 is a novel Positron Emission Tomography (PET) radiotracer which can be used to detetect 18kDa translocator protein (TSPO) distribution in vivo. Murine brain TSPO atlases were generated using average SUV at 90-120 ... -
SUPERSEDED - Average male, female and mixed gender mouse TSPO brain maps, generated using TSPO PET radiotracer [18F]LW223 (unnormalized to injected dose)
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2988 ## [18F]LW223 is a novel Positron Emission Tomography (PET) radiotracer which can be used to detetect 18kDa translocator ... -
Additional image (Fig 2) - Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer
This image is part of the dataset: MacAskill, Mark. (2020). Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer, [image]. University of ... -
Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer
DICOM imaging data sets, CT and PET. Distribution and kinetics of [18F]AB5186 in rats. Please note one of the images is in a separate Item in this repository, please see: MacAskill, Mark. (2020). Additional image (Fig 2) ...