Jefferson Urology Year In Review 2023 by Jefferson Urology

Year in Review 2023 Department of Urology For more information on how philanthropic gifts can help support our research, teaching and patient care missions, contact: Leonard G. Gomella, MD, FACS The Bernard W. Godwin Jr. Professor of Prostate Cancer Chair, Department of Urology, Sidney Kimmel Medical College Senior Director Clinical Affairs, Sidney Kimmel Cancer Center, Thomas Jefferson University Enterprise VP for Urology, Jefferson Health 1025 Walnut Street, Suite 1100 | Philadelphia, PA 19107 215-955-1702 Leonard.Gomella@jefferson.edu

P. Kenneth Brownstein, MD, FACS Department of Urology Director of Philanthropy Harold A. Honickman Physician Director of Jefferson Signature Services Office of Institutional Advancement Thomas Jefferson University and Jefferson Health 125 S. 9th Street, Suite 600 | Philadelphia, PA 19107 215-503-2111 Kenneth.Brownstein@jefferson.edu

Elena Boroski Director of Development Sidney Kimmel Cancer Center & Clinical Programs Office of Institutional Advancement Thomas Jefferson University and Jefferson Health 125 S. 9th Street, Suite 600 | Philadelphia, PA 19107 267-225-8380 Elena.Boroski@jefferson.edu

“Jefferson Urology 2023 Year in Review” Design and Production Editor: Tricia Shea Editor-in-Chief: Leonard G. Gomella, MD Contributors: Elena Boroski Zoe Brun Paul Chung, MD Anthony V. Coppola Barbara Devine Sonny Figueroa, MD Tricia Gomella, MD

Janice Harper Lisette Hilton Costas Lallas, MD Matt Schiewer, PhD Patrick Shenot, MD Denise Tropea Hong Troung, MD Marlene Vallett

Photography: Karen Kirchoff, Robert Neroni Additional Department of Urology information can be found at: www.jefferson.edu/university/jmc/ departments/urology For digital versions of “Jefferson Urology 2023 Year in Review” and other years 2019-2022, search “Jefferson Urology” on the issuu.com website. Published by the Department of Urology, Thomas Jefferson University 1025 Walnut Street, Suite 1100, Philadelphia, PA 19107 215-955-6961 (tel), 215-923-1884 (fax) Correspondence: Dr. Leonard Gomella, Editor, Leonard.gomella@jefferson.edu Copyright @2023 Thomas Jefferson University. All rights reserved. v 1.0

Year in Review

Year in Review 2023 FEATURES 4 Jefferson Urology & the NCI Connections 12 Giving Back to the Community: Leon & Fran Levy 13 Honickman Center: A New Era for Urology 14 Investiture of Dr. Costas Lallas RESEARCH UPDATE 15 Overactive Bladder and INTIBIATM Study 16 Urology Clinical Trials 16 Philadelphia Prostate Cancer Biome Project Update 17 Basic Science Update from the Schiewer Urology Lab NATIONAL MEETINGS 18 Mid-Atlantic AUA Annual Meeting 2023 20 AUA 2023 Chicago 22 SUNA 2023 22 Society of Women in Urology Mentorship Conference 22 New York GUTM 16th Annual Program GLOBAL ENGAGEMENTS & INTERNATIONAL AFFAIRS 23 2023 SIU in Istanbul, Turkey 24 President of the Dual MD Jefferson and Cattolica University in Rome 24 Poznan University of Medical Sciences 25 KLE Student Exchange 2023 25 23rd Asia Pacific Prostate Conference 26 Visiting Professors & Guest Lecturers 2023 30 New Faculty 31 Faculty Spotlight 32 Faculty Notes 36 News from the Division of Pediatric Urology 39 Provider Spotlight 40 Notable & Newsworthy 46 Community Outreach & Engagement 50 Graduations & Awards 53 2023 Urology Graduation Celebration 58 Residents and Fellows 2023-2024 62 Student News 66 Alumni News 70 In Memoriam: Leonard Frank, MD 71 Year in Photos 74 Faculty Listing 75 Outpatient Locations 75 Jefferson Medical Group Urology Practices 76 Publications 2023 79 What Patients Are Saying 80 By the Numbers

Chair’s Letter Dear Friends, Welcome to our Jefferson Urology “Year in Review 2023,” which highlights our major achievements and activities over the last year and gives a preview of what is to come in 2024. This is our 5th consecutive year producing a publication that reviews our teaching, research and patient care activities to share with our readers. Our Department welcomed several new faculty members in 2023. Drs. Adam Metwalli and Paul Bloch are both experienced clinicians with Dr. Metwalli supporting our urologic oncology program and Dr. Bloch expanding our general urology patient care in South Jersey and Center City. You can read more about their credentials on page 30. We also welcomed pediatric urologist Dr. Pat Casale back to Jefferson as a Professor of Urology, and a national leader in robotic surgery for children (page 36). Outside of our Department, Jefferson Health welcomed several new key leaders over the last year. Dr. Baligh R. Yehia became the President of Jefferson Health in early 2023 and is responsible for all of our system hospitals and patient care. Dr. Susan Aldrich has been appointed interim President of Thomas Jefferson University, bringing her experience in leading academic programs at universities such as Drexel and Maryland, to name a few. Jefferson recently named Said Ibrahim, MD, MBA, MPH, as Dean of the Sidney Kimmel Medical College and President of Jefferson University Physicians. Dr. Ibrahim joined us on December 1, 2023, having most recently served as senior vice president of Northwell Health’s Medicine Service Line in New York. Dr. Matt Baker is now formally our University Provost and will continue his legacy of fostering an environment of interdisciplinary collaboration among the academic units. The Department of Urology looks forward to working with these important Jefferson leaders, and we wish them all well. A few other significant achievements and recognitions to highlight: • In the 2023-24 U.S. News National Hospital Ranking, Jefferson Urology moved up to #30 in the Top 50. • The 2023 Doximity Residency Ranking listed our TJUH/Jefferson Urology residency as #19 out of 150 registered programs. • Dr. Costas Lallas became the 6th Nathan Lewis Hatfield Professor of Urology (page 14). • Thomas Jefferson University ranked #48 in the WSJ/College Pulse 2024 Best Colleges in the U.S. list — a rating of the nation’s top 400 universities. • Jefferson Health was recognized by Forbes as being among America’s best hospitals to work for in Pennsylvania and New Jersey. • Under the leadership of Interim Dean, Dr. Steve Herrine, our medical school achieved full accreditation through the year 2031. The coming year, 2024, will be a very important one for our Department and all of Jefferson Health. Our Center City office will be moving to our new clinical home, the Honickman Center, with the grand opening scheduled for April. Our patient offices will be on the 11th floor of the center, located on Chestnut between 11th and 12th Streets (page 13). In collaboration with the Sidney Kimmel Cancer Center, we will be launching our new comprehensive focal therapy program for the treatment of localized prostate cancer (page 44). The final results of Dr. Paul Chung’s 2022 urology research project on the International Space Station will be published in 2024. The research findings of changes in the urinary micro-biome will have significant impact on future long distance space travel. For details on this space station research see our “Year in Review” 2021 and 2022. We anxiously await the announcement from the NCI if our Sidney Kimmel Cancer Center will be become a Comprehensive Cancer Center, the highest designation achievable. Not to be missed will be the bicentennial celebrations of the founding of Jefferson, 200 years of tradition, growth, discovery, and healing. Our 2023 cover features a view of the Clinical Center of the NIH, home base for the NCI in Bethesda, Maryland. The article on page 4 highlights the amazing connection between the National Cancer Institute and Jefferson Urology, encompassing students, residents and faculty over many years. See what we have been up to with our local community outreach and what we have done on the stage of national and international urology meetings. This issue also highlights our outstanding series of visiting professors and guest lecturers. I can go on and on about the accomplishments of our other faculty, residents, researchers and students over the past year, but all of these topics and more are presented in this 2023 “Year In Review.” The majority of our academic work outside of direct patient care is only made possible through philanthropy. Our generous donors see the value of our commitment to train the next generation of urologists and help us to discover the newest ways to diagnose and treat benign and malignant urologic conditions. Thank you for taking the time to learn about our great department. If you have any questions or comments, please contact me. My email is leonard.gomella@jefferson.edu. Sincerely,

Leonard G. Gomella, MD, FACS The Bernard W. Godwin Professor of Prostate Cancer Chair, Department of Urology, Sidney Kimmel Medical College Senior Director Clinical Affairs, Sidney Kimmel Cancer Center Enterprise VP for Urology, Jefferson Health Jefferson Urology

Jefferson Urology and NCI Connections

Year in Review

Throughout the years, there has been a strong connection between Jefferson’s Department of Urology and the National Cancer Institute (NCI) at the National Institutes of Health (NIH) in Bethesda, Maryland. These interactions extend from the early days of the NCI Surgery Branch through the establishment of the Urologic Oncology Branch (UOB) in 1997. Several current and past Jefferson Urology faculty completed NCI surgical oncology fellowships. Over the past decade, a number of Sidney Kimmel Medical College (SKMC) students also participated in NIH-sponsored research fellowship programs at the NCI-UOB and went on to residency training in urology. BACKGROUND ON THE NATIONAL CANCER INSTITUTE (NCI) The NCI is the federal government's principal agency for cancer research and training and is part of the National Institutes of Health. One of its many missions is to support training for current and future cancer researchers. The NCI offers many training opportunities including intramural training programs offered at the NCI laboratories and the Clinical Center in Bethesda. This is where our Jefferson colleagues are based when working at the NCI’s main campus. Here physicians and scientists are engaged in a wide variety of basic science studies and clinical trials to develop novel treatments for many different diseases. The cancer investigations at the NCI are a major focus. Dr. Elwin E. Fraley led the first urology efforts in the Surgery Branch of the NCI followed by Nasser Javadpour until 1982. At that time, Dr. Marston Linehan (pictured right) became the Chief of Urology in the Surgery Branch working with Director Dr. Steven Rosenberg. Although there was no formal urologic oncology fellowship before the creation of the Urologic Oncology Branch, urology trainees, who were interested in academic careers, served as surgical oncology fellows (designated as “Clinical Associates”) in the NCI’s Surgery Branch. They participated in a wide variety of complex surgical oncology cases including caring for patients with melanoma, sarcomas and a variety of solid tumors including, lung, liver, breast, adrenal, testicular and, of course, kidney cancer. All patients treated at the NCI are on a research protocol, and the cost of care is covered including transportation from all parts of the United States. A core element of these Surgery Branch fellowships was the requirement to perform basic science research alongside PhDs and surgeon scientists.

(SKMC Class of 1978), Arie Belldegrun, Joseph “Peppy” Wagner, Stephen Strup (TJU resident 1997), Jonathan Coleman, Rob Reiter, and others. Jefferson’s own current and past faculty, who completed fellowship training at NCI, include Drs. Demetrius Bagley, Leonard Gomella, Stephen Strup, Patrick Gomella, and Adam Metwalli. Reflections by these Jefferson Urology faculty and our SKMC students begin on page 7. From its roots in the Surgery Branch, Dr. Linehan led the effort to develop the Urologic Oncology Branch into its own identity in 1997. With this change, Dr. Linehan became Chief of the Urologic Oncology Branch of the NCI and developed a focused urologic oncology fellowship including Society of Urologic Oncology certified trainees. Current urology faculty at the NCI-UOB include Drs. Linehan, Peter Pinto, Mark Ball, Vladimir Valera, and Sandeep Gurram. The NCI-UOB has served as a research training epicenter for many SKMC students through programs such as the NIH Medical Research Scholars Program (MRSP). The MRSP is a comprehensive yearlong research enrichment program,

Some notable academic urologists who obtained training at the NCI include Drs. David Paulson, Jean DeKernion, Ruben “Ben” Gittes, Mark Soloway, Peter Scardino, William Catalona, Gabriel Haas, Cary Robertson, Gerald Andriole

Jefferson Urology

Jefferson Urology and NCI Connections which provides mentored training to researchoriented medical, dental, and veterinary students. Based on the main NIH campus in Bethesda, Maryland, the program enables aspiring future physician-scientists to engage in basic science, clinical, or translational research in areas that match their professional interests and research goals. Students most commonly participate in the program between their third and fourth years of medical school. MRSP scholars engage in a rigorous research curriculum, which includes a curated lecture series focusing on career development, a structured course on research methodology, journal club seminars, and clinical teaching rounds. MRSP scholars commonly present their research to the NIH community and at regional, national, and international conferences.

SKMC has done an exceptional job in fostering students’ interest in biomedical research. Since 2009, eleven SKMC students have been selected to participate in the prestigious NIH MRSP program. Six of the students, who were selected to work at the UOB, have chosen a career in urology. At the time of this article, Jason Hyman, SKMC Class of 2025, is participating in the Medical Research Scholar Program and plans on applying to a urology residency program. In addition to highlighting the connections between Jefferson Urology and NCI, notable contributions of the Surgery and Urologic Oncology Branches have had a major impact on the diagnosis and treatment of malignancies in general and urologic cancers in particular. A few of these include the

development of IL-2 and the various immunotherapy approaches for kidney and other cancers. The identification of the VHL gene and other hereditary kidney cancer genetic syndromes have been made by Dr. Linehan and associates. Dr. Linehan has demonstrated that renal cell carcinoma, once considered a single disease, is made up of several different types of cancer, each with a different histology, a different clinical course, responding differently to therapy, and caused by different genes. He and his colleagues recently published a description and characterization of the 19th kidney cancer gene and the 15th form of genetically defined, hereditary kidney cancer. Dr. Linehan and associates performed basic research and clinical trials of a new agent, belzutifan, revealing dramatic responses in kidney cancer and other tumors. This led to recent FDA approval of this agent for patients with renal cell carcinoma and other diseases. The pioneering work on MRI fusion prostate biopsies by Dr. Peter Pinto and associates has revolutionized the diagnosis and management of men with prostate cancer. Many members of our Jefferson family have worked on these significant scientific projects.

Notable contributions of the Surgery and Urologic Oncology Branches have had a major impact in the diagnosis and treatment of malignancies in general and urologic cancers in particular.

Year in Review

JEFFERSON BIOGRAPHIES We are pleased to present this “Jefferson Urology and the NCI Connections” review. Here are brief biographies on trainees from Sidney Kimmel Medical College, Jefferson Urology residency and others, who have benefited from their time at the NCI as students, fellows or faculty members. Dr. Linehan has kindly contributed a letter (see page 6) sharing his perspectives on the strong connections between Jefferson Urology, SKMC and the NCI throughout the years. The cover of our “2023 Year in Review” features the NIH Clinical Center in Bethesda with a collage of images capturing NCI memories from our Jefferson colleagues.

(As told to Drs. Troung and Chung before Dr. Bagley’s passing in 2022.) “I was in the Surgery Branch of the NCI as a Clinical Associate, the formal title for fellows, from July 1972 to June 1975. Dr. Alfred Ketcham was the chief of the Surgery Branch and Dr. Steven Rosenberg served as chief during the third year of my Fellowship. “At that time, fellows typically completed two years of general Demetrius H. Bagley, MD surgery residency before starting NCI: Surgical Oncology Fellow, their time at the NCI. The first year Surgery Branch 1972-1975 was predominantly clinical, rotating on different services with the major Previous Position: Professor of Urology and diseases studied in the Surgery Radiology, Sidney Kimmel Medical Branch, which at that time, included College 1983-2022 melanomas, head and neck tumors, and advanced pelvic malignancies. The most demanding time was on the consult rotation. One clinical associate and one attending were the on-call surgeons for the Clinical Center at the NIH in Bethesda, a very busy hospital for protocol patients with a wide variety of very unusual disorders. For example, one weekend when I was on call, we operated all weekend starting on Friday evening. There were leukemic patients with appendicitis and a nearly acellular abscess, and a patient with paroxysmal nocturnal hemoglobinuria with spontaneous bowel infarctions. Just a few examples of the usual range of patient disease. The second year consisted of full-time research under the direction of a mentor with access to collaboration with other clinical associates and the entire NIH staff. Dr. Robert Beasley, who went onto a professorship in Boston, was my mentor. “When I first arrived at the NCI there was no staff urologist after Dr. Elwin Fraley had left to become the chair at the University of Minnesota. There was a private practice urologist in Washington, DC, who served as our urologic consultant with Dr. Nassar Javadpour joining the Surgery Branch as urologist during my second fellowship year. Dr. Peter Scardino joined as a clinical associate that same year. Peter worked directly with Nassar and we had many collaborations. There were no other future urologists among the clinical associates during those early years. I stayed on for a third year to complete research and to participate in the Variable Incentive Pay program, which included a nice bonus designed to retain government workers. “My years at the NCI were very fruitful. One of my main study areas was cryosurgery. We established many of the techniques for successful treatment and tissue monitoring using unique temperature probes. We studied the effects of freezing tissue in nerves, the ureter and kidneys. In collaboration with others, cytotoxicity was described in animal models of cryotherapy with the availability of many patients with tissue flaps constructed for their resections. Another project was to measure antibiotic levels in wound fluids. In collaboration with the radiologists,

we performed lymphangiograms and evaluated the role of many routine diagnostic studies performed on cancer patients. With my commitment to a career in academic medicine, my next stop was as a urology resident at Yale University, a brief period on the faculty at the University of Chicago, and then ultimately joining Jefferson‘s Department of Urology in 1983.” “After completing residency at the University of Kentucky in Lexington in 1986, I was honored to be selected as one of eight Clinical Associates for a two-year training program in the Surgery Branch of the NCI in Bethesda. Dr. Bill McRoberts, the UK Chief of Urology, encouraged me to apply to the NCI program. Dr. Steve Rosenberg was the Branch Chief and Dr. Marston Linehan was the head of Urology. At the time, there was no formal Urologic Oncology fellowship Leonard G. Gomella, MD, FACS program, and each year 1-2 fellows NCI: Surgical Oncology Fellow, Surgery were chosen from the pool of Urology Branch 1986-1988 applicants. The program provided an intense exposure to all aspects of Current Position: Department of Urology, SKMC surgical oncology with each patient 1988-present; The Bernard Godwin participating in an investigational Jr. Professor of Prostate Cancer, study. My NCI surgical training Chair Department of Urology involved caring for patients with Sidney Kimmel Medical College, Senior Director for Clinical Affairs, melanoma, hepatocellular carcinoma, Sidney Kimmel Cancer Center, adrenal malignancies, lung cancer 2002-present and patients with advanced renal malignancies to name just a few. This also included serving on the general surgical consultation service for all NIH patients in the Clinical Center. “The goal of these Surgery Branch fellowships was to prepare surgeons for careers in academic medicine. During the 24-month program, six months were dedicated to clinical care with the other 18 months focused on bench research. During our research time, fellows participated in a weekly clinic evaluating new patients for clinical trials and following the course of patients previously treated. “Reflecting back on my two years at the NCI, working with the incredible group of attendings, all outstanding surgeon scientists, was transformational and reinforced my academic career plans. Under the leadership of Drs. Rosenberg and Linehan in the 1986-1987−time frame, the Surgery Branch was offering a pioneering new treatment for advanced malignancies that previously had no therapeutic options. The focus of work was interleukin 2 (IL-2), a naturally occurring cytokine that could activate T cells to destroy a variety of cancers. This was a novel immunotherapy discovery resulting in major remissions in a variety of malignancies. Prominent among them was renal cell carcinoma, a malignancy that I would devote my research time to as a fellow. The IL-2 discovery was so significant that Dr. Rosenberg was featured on the cover of magazines such as Newsweek, with frequent visitors coming to the Surgery Branch, including Presidents Carter and Reagan and many prominent journalists, such as Tom Brokaw covering this breakthrough discovery. “My project was studying fresh renal cell carcinomas for tissue culture and to provide high-quality samples for immunotherapy research. In addition, these samples laid the groundwork for the discovery of the VHL and other tumor-related kidney cancer genes that Dr. Linehan would devote the next 30 years of his career to identifying. Jefferson Urology

Jefferson Urology and NCI Connections “The focus of most of the Surgery Branch during my tenure was the study of immune responses utilizing a variety of techniques such as chromium release assays, with the assays running 24 hours a day. However, I had heard about something called ‘Northern and Southern blots’, which were being performed in the breast cancer labs in the NCI Medical Oncology Branch. The field of molecular biology was taking off in 1986 with the discovery of ways to efficiently produce DNA using RT-PCR technology. With Dr. Linehan’s encouragement, I spent time learning the basics of molecular biology with breast cancer researcher Dr. Attan Kasid. I had the privilege of developing the firstever molecular biology protocols used in the Surgery Branch in 1987. Some of our earliest discoveries involved the identification of growth factors in renal cell carcinoma, such as TGF-alpha and TGF-beta. I was fortunate to receive an NCI Achievement Award in 2000 presented by then NCI Director, Dr. Andy VonEschebach, and Dr. Linehan for this work. (See photo on page 9.) “Based on my NCI fellowship, I was recruited to Jefferson by Dr. Joseph Gonnella, Dean of Jefferson Medical College and Dr. Grant Mulholland, Urology Chair, in 1988. It was Dr. Gonnella’s vision to have an NCIdesignated cancer center at Jefferson. His dream became a reality in 1995 with the establishment of the Sidney Kimmel Cancer Center. My NCI fellowship experience provided me the opportunity to work on the earliest days of our cancer center journey from the creation of the Jefferson Cancer Institute to the first SKCC NCI designation. My fellowship also allowed me to collaborate with outstanding Jefferson scientists such as Drs. Carlo Croce, Ned Lattime, Renato Baserga, Mike Mastrangelo, Karen Knudsen, Mat Thakur, and many others. None of these collaborations could have taken place without the thoughtful design and government support of these training fellowships at the NCI.”

Gerald L. Andriole, MD, FACS NCI: Surgical Oncology Fellow and Cancer Expert 1983-1985 Jefferson: SKMC Class of 1978 Previous Positions: Chair, Division of Urology Washington University, St Louis 1998-2021; Professor of Urology, Brady Urologic Institute, Johns Hopkins Medicine 2021-2023 Current Position: Chief Medical Officer, Prostatype Genomics

“I arrived at NCI after the completion of my Urology residency training at the Brigham and Women’s Hospital and Harvard Medical School. I served as a Clinical Associate (Fellow) and was also designated as an NCI ‘Cancer Expert’. During this time at NCI, with the mentorship of the Chief of Urology, Dr. Marston Linehan, I was charged with examining prostate cancer-induced bone resorption in a novel mouse calvarial bone assay. The goal was to determine whether bisphosphonates could inhibit the resorption and maintain bone health. A second line of research examined the effect of 5-alpha reductase inhibitors on the growth of prostate cancer in murine models. Subsequently in 1985, I joined the Urology faculty at Washington University in St. Louis and ultimately became the Chief of Urology, a position I held for more than 20 years.

“These NCI basic science investigations taught me the techniques and methodology of translational biomedical research and laid the foundation for my future involvement in and leadership of investigations of both of these medications in prostate cancer clinical trials. My NCI experience allowed me to oversee a large departmental research program. The NCI research studies also provided a basis to continue prostate cancerrelated research and lead both the Prostate Committee of the NCI8

Year in Review

funded PLCO cancer screening trial and the Steering Committee of the international REDUCE prostate cancer chemoprevention trial.” (See page 66 for more details on the career of Dr. Andriole, who was our 2023 Jefferson Urology Alumni Award recipient.)

Joseph Baiocco, MD NCI: Medical Research Scholar 2016-2017; Cancer Research Training Award Fellow 2017-2018 Jefferson: SKMC Class of 2019 Current Position: Chief Urology Resident, Icahn School of Medicine at Mount Sinai, New York

Ashish Behari MD NCI: Urologic Oncology Fellow 2003-2005 Jefferson: SKMC Class of 1997

“While at the NCI-UOB, I conducted translational research investigating metabolic alterations as targets for novel therapies in castration resistant prostate cancer. I was also able to participate in clinical research studying the role of MRI/ US fusion biopsy in prostate cancer and treatment options of multifocal renal cell carcinoma. During my first year at NCI-UOB, I was fortunate to be presented a Cancer Research Training Award to continue research for a second year. I am currently finishing my urology residency at Mount Sinai in New York City and will be completing a fellowship in Genitourinary Trauma and Reconstruction at Washington University in St. Louis starting in 2024.”

“The NCI Fellowship was an incredible experience for me. I did clinical work on extra adrenal pheochromocytoma as well as other adrenal diseases, including tremendous surgical experience in adrenalectomy. Additionally, I worked on clinical trials for HSP90 inhibitor 17AAG. The extraordinarily talented people at NCI-Urologic Oncology Branch were the best part of the experience. To be a part of Friday conferences was an educational experience in and of itself. I treasured my time there.”

Current Position: Site Director, Wellspan Urology Chambersburg, PA

These NCI basic science investigations ... laid the foundation for my future involvement in and leadership of investigations in prostate cancer clinical trials. ~ Gerald L. Andriole, MD, FACS

My time at the NCI with the Urologic Oncology Branch confirmed a passion in urology and ignited my own interest in clinical research and patient outcomes. ~ Michele Fascelli, MD

“I was selected to participate in the Medical Research Scholar Program at NCI from 2016-2017 in Bethesda, Maryland. I spent the year in the clinical laboratory of Dr. Peter Pinto, head of the prostate cancer division of the Urologic Oncology Branch, working on developing techniques to better detect clinically significant prostate cancer using MRI-TRUS fusion-guided biopsies. My year there was an incredible experience that offered me firsthand exposure Brian Calio, MD to groundbreaking clinical research NCI: Medical Research Scholar 2016-2017 and allowed me to participate in Jefferson: SKMC Class of 2019 a meaningful way toward project design, data analysis, and manuscript Current Position: development. I worked closely with Chief Resident, Department of Urology, Thomas Jefferson fellow medical students from across University Hospital the country, fellows, and attendings, and together we published several articles in high impact journals including the Journal of Urology. Friends I made during that year I keep in touch with to this day, and I consider Dr. Pinto a lifelong mentor. I am extremely grateful for my time there and have no doubt I will use the skills learned in my urology career. Next year, I will be starting a urology fellowship at Duke.”

Paul H. Chung, MD, FACS NCI: Clinical Research Training Program Fellow, Urologic Oncology Branch 2009-2010 Jefferson: SKMC Class of 2011 Current Position: Associate Professor, Department of Urology, SKMC 2017-present

Michele Fascelli, MD NCI: Medical Research Scholar 2014-2015 Jefferson: SKMC Class of 2016 Prior Positions: Urology Resident, Cleveland Clinic 2016-2022; Fellowship in Genitourinary Reconstruction and Genital Gender Affirming Surgery, Oregon Health and Science University 2022-2023 Current Position: Assistant Professor, Reconstructive Urology and Genital Gender Affirming Surgery, Cleveland Clinic, 2023-present

“My time at NCI with the Urologic Oncology Branch confirmed a passion in urology and ignited my own interest in clinical research and patient outcomes. While at NCIUOB, I worked closely with Dr. Peter Pinto in publishing ongoing outcomes from MR/US fusion biopsy following the work of prior Medical Research Scholar students. I developed fundamental skills in formulating a research question, generating and sharing results, and ultimately publishing our work. I then completed medical school and went on to Cleveland Clinic for urology residency (2016-2022) and completed a fellowship in Genitourinary Reconstruction and Genital Gender Affirming Surgery at Oregon Health and Science University in Portland, OR (20222023). I am currently an Assistant Professor at Cleveland Clinic with a primary focus in providing urologic care to gender-diverse patients, improving access for LGBTQIA+ people, and augmenting the current genital gender affirming surgical services in northeast Ohio.”

“My time at the NCI-UOB as a medical student in the Clinical Research Training Program will always be memorable. I will be forever thankful for the research experience guided by lifelong mentors Drs. Peter Pinto and Gennady Bratslavsky, and clinical fellows Drs. Ardershir Rastinehad, Angelo Baccala, and Gopal Gupta. I contributed to the first MRI-US fusion-guided prostate biopsy manuscripts published in the Journal of Urology. I gave my first-ever presentation as a podium at GU ASCO on the impact of race on RCC histological subtypes and stages utilizing the SEER database. I also evaluated low temperature-sensitives liposome encapsulated docetaxel with Drs. Ashish Ranjan and Brad Wood in a mouse model of prostate cancer.” Jefferson Urology

Jefferson Urology and NCI Connections “I actually started my time at the Urologic Oncology Branch as a senior resident during my residency at George Washington University. I was privileged to continue my oncologyfocused clinical and research experience as a Society of Urologic Oncology fellow at the NCI after residency graduation. I worked closely with both the kidney and prostate cancer sections under the mentoring and direction of Drs. Linehan, Pinto, Metwalli and Wood on several research projects related to hereditary Patrick T. Gomella, MD, MPH kidney cancer, pheochromocytoma NCI: George Washington as well as imaging, diagnostic, and University Urology Resident 2016; interventional approaches for prostate NCI: Society of Urologic Oncology cancer. I was especially proud to be Fellow 2018-2021 Jefferson: SKMC Class of 2013 part of a high-impact update on the NCI experience in MRI/US fusion Current Position: Assistant biopsy in the diagnosis of prostate Professor, Department of Surgery cancer with my co-fellows that was and Urology, SKMC 2021-present published in the New England Journal of Medicine in 2020. I returned to Jefferson in 2021 as a full-time academic faculty member. I have a particular interest in focal therapy for prostate cancer and am currently the co-director for our newly established focal therapy program along with a former NCI faculty member and longtime mentor, Dr. Adam Metwalli, who has recently joined our department.” “The years 2017-2018 were a fantastic time to be at the NIH. I worked under the direction of Dr. Peter Pinto and his fellow, Dr. Jon Bloom, on various prostate cancer research projects. We formed a working group with the radiology, interventional radiology, oncology, and pathology departments to support each other’s projects. These included antiandrogen clinical trials, studying features of the UroNav system, refining AI-assisted mpMRI interpretative algorithms, developing VR navigational tools to assist with Graham Hale, MD surgery, and evaluating a new device NCI: Medical Research Scholar for automated image re-registration 2017 -2018 to compensate for motion during Jefferson: SKMC Class: 2019 prostate surgery and procedures – Current Position: PGY5 Urology which won a best poster award at resident at University of Illinois, the 2018 AUA annual meeting. The Chicago impact of this year, and the people involved, cannot be understated. I think the most valuable gift I received was a clear understanding of my own interests and the type of research I enjoy and continue with today. I’d like to thank the faculty at Jefferson whose support and guidance made this NCI experience possible: Drs. Lallas, Trabulsi, and Gomella.”

The NCI Urologic Oncology Branch (UOB) has been pivotal in my career and a constant influence from very early in my training. ~ Adam R. Metwalli, MD 10

Year in Review

“I am currently a Jefferson medical student utilizing a gap year to conduct translational research with the NCI-UOB under the direction of Dr. Marston Linehan, specifically on various projects related to hereditary kidney cancer syndromes. So far, I have been studying genetic clonal evolution of renal tumors in VonHippel-Lindau disease. I have also been assisting in the efforts to study belzutifan, a novel HIF-2α inhibitor, for the treatment of all tumor types that arise in Von-Hippel-Lindau Jason Hyman, BS disease. The NIH additionally offers NCI: Cancer Research Training courses that I am taking to learn Award Fellow 2023-2024 coding and statistics to enhance my Jefferson: SKMC Class of 2025 research skills. I have been enjoying the opportunity to work with the other fellows and faculty to collaborate on a wide range of projects. I am from Bucks County, Pennsylvania, and completed my undergraduate education at Tulane University. I plan to pursue a career in urology after graduating from Sidney Kimmel Medical College.” “I am an NCI man through and through. The NCI Urologic Oncology Branch (UOB) has been pivotal in my career and a constant influence from very early in my training. I first encountered Dr. Marston Linehan at the Basic Sciences course in Charlottesville as a PGY-2. I was immediately convinced that urologic oncology was my future career after hearing him speak. A few years later, I started a three-year urologic oncology fellowship at MD Anderson Cancer Center in Houston, TX, in 2005. After Adam R. Metwalli, MD two years in Houston, I moved to the NCI: Fellow, 2007-2008; Urologic DC area for personal reasons. Dr. Oncology Branch Faculty 2011Linehan was kind enough to allow 2017 me to complete the third year of my Current Position: Clinical oncology fellowship at the NCI. That Professor, Department of Urology, was an interesting year because we SKMC 2023-present only had three fellows when normally there would be 6, and each of us was a first year fellow at NCI that year. I returned to the NCI as a staff clinician three years later and spent 7 ½ years there as staff clinician. During that time, I had the privilege of working with and training an all-star cast of medical students, residents and fellows including many with links to Jefferson discussed in this article, including Drs. Hong Truong, Joseph Baiocco and Patrick Gomella. Moreover, some of the trainees I worked with at NCI have gone on to prominent positions in academic urology, including an Endowed Chair in Kidney Cancer Research at UCLA, Chair of Urology at Georgetown, Endowed Chair of Urology at Ohio State, which is a testament to the caliber of people who have come through the UOB program. “During my time on the NCI faculty, I expanded the use of robotic surgery in the management of hereditary renal cell carcinoma in the primary, re-operative and salvage settings. I also established a collaboration between the UOB and the Center for Prostate Disease Research (CPDR) at Walter Reed National Military Medical Center. This collaboration was only possible because the director of CPDR was my co-fellow at NCI during my final fellowship year. My affiliation with the NCI did not stop once I left to become Chief of Urology at Howard University Hospital. I maintained special volunteer status at NCI and

JEFFERSON UROLOGY AND THE NCI CONNECTIONS continued to collaborate with members of the Urologic Oncology Branch and the Molecular Imaging Program. These collaborations ultimately resulted in a successful collaborative grant funding project to investigate polygenic risk scores in prostate cancer involving Howard, the UOB and Harvard. Virtually every professional accomplishment I have achieved traces back in some way to my time in Bethesda on the NIH campus.”

Stephen E. Strup, MD, FACS NCI: Fellow, Surgery Branch 1994-1996 Jefferson: Urology Resident 1988-1994 Current Position: James F. Glenn Professor and Chairman, Department of Urology University of Kentucky College of Medicine, Lexington, Kentucky, 2003-present

“My time at the NCI laid the foundation for my career in academic Urologic Surgery. The sheer research power of the NCI Surgery branch was marvelous. I vividly recall my first ‘branch tea’, where an auditorium of brilliant scientists presented progress on their cancer research projects. I was fortunate to be at the NCI when Dr. Marston Linehan and his team were unlocking the genetics behind renal cell cancer. I was part of a team who took those principles and worked to understand and further define prostate cancer genetics. We were also in the ‘surgery branch’ at that time so our Urology faculty and fellows were grouped with Dr. Steven Rosenberg’s team working on immune therapy for diseases such as melanoma. It was an era of ‘big surgery’ and discovery. The current management of renal cell cancer expanded from these surgery branch roots led by Dr. Linehan. I am honored and proud to be part of the NCI and Jefferson family trees.”

“My time as a research scholar at the Urologic Oncology Branch at the NCI was truly transformative. Immersed in the world of urologic oncology and state of the art research, I was captivated by the challenges and potential for groundbreaking research in understanding and treating urologic cancers. Working under the mentorship of Dr. Pinto and the NCI urologic oncology fellows, I participated in research projects that helped to transform prostate MRI from an experimental concept into standard of care for patients. The Hong Truong, MD NCI: Medical Research Scholar experience at the NCI also ignited 2012-2013 a passion within me to explore the Jefferson: SKMC Class of 2014; complex genetic underpinnings Jefferson Urology Resident of urologic cancers and their 2014 -2020 implications for precision medicine, Current Position: Assistant setting the course for my current Professor of Urology, Penn research and clinical endeavors. State University College of Following a six-year Urology Medicine, Hershey, Pennsylvania 2022-present residency at Jefferson, I completed a fellowship in Urologic Oncology at Memorial Sloan Kettering Cancer Center in New York in 2022. I am currently an Assistant Professor of Urology at Penn State University College of Medicine in Hershey, Pennsylvania.”

This list is based on their first date at Jefferson or SKMC. GERALD ANDRIOLE, MD NCI Fellowship, Surgery Branch, 1983-1985; SKMC Class of 1978 DEMETRIUS BAGLEY, MD NCI Fellowship, Surgery Branch, 1972-1975 SKMC Faculty 1983-2022 LEONARD GOMELLA, MD NCI Fellowship, Surgery Branch, 1986-1988; SKMC Faculty 1988-present STEPHEN STRUP, MD Jefferson Urology Resident 1988-1994; NCI Fellowship, Surgery Branch 1994-1996; SKMC Urology Faculty 1996-2003 ASHISH BEHARI, MD SKMC Class of 1997; NCI Fellowship, Urologic Oncology Branch 2003-2005 PAUL CHUNG, MD NCI Medical Research Scholar 2009-2010; SKMC Class of 2011 SKMC Urology Faculty 2017-present PATRICK GOMELLA, MD, MPH NCI Fellowship, Urologic Oncology Branch 2018-2021; SKMC Class of 2013; SKMC Urology Faculty 2021-present HONG TRUONG, MD NCI Medical Research Scholar 2012-2013; SKMC Class of 2014; Jefferson Urology Resident 2014-2020 MICHELE FASCELLI, MD NCI Medical Research Scholar 2014-2015; SKMC Class of 2016 BRIAN CALIO, MD NCI Medical Research Scholar 2016-2917; SKMC Class of 2019 Jefferson Urology Resident 2019-2024 JOSEPH BAIOCCO, MD NCI Medical Research Scholar 2016-2018; SKMC Class of 2019 GRAHAM HALE, MD NCI Medical Research Scholar 2017-2018; SKMC Class of 2019 JASON HYMAN, BS NCI Medical Research Scholar 2023-2024; SKMC Class of 2025

ADAM METWALLI, MD NCI Fellowship 2007-2008; NCI Faculty, Urologic Oncology Branch 2011-2017; SKMC Urology Faculty 2023-present Jefferson Urology

Year in Review

Jefferson Urology

Investiture of Dr. Costas Lallas

The 6th Nathan Lewis Hatfield Professor of Genito-Urinary Surgery Participants in the February 7, 2023, installation of Dr. Costas Lallas as the 6th Nathan Lewis Hatfield Professor of Genito-Urinary Surgery. From left to right: Mr. Harry Donahue, Philadelphia radio broadcasting legend and Master of Ceremonies; Dr. Mark Tykocinski, Thomas Jefferson University past President and former Dean of Sidney Kimmel Medical College; portrait of Dr. Hatfield; Dr. Lallas with the professorship proclamation; and Dr. Leonard Gomella, Chair, Department of Urology. On February 7, 2023, Sidney Kimmel Medical College of Thomas Jefferson University installed Dr. Costas D. Lallas as the 6th Nathan Lewis Hatfield Professor of GenitoUrinary Surgery. Dr. Lallas is Professor and Vice Chair for Education in the Department of Urology at the Sidney Kimmel Medical College and also currently serves as residency program Director for Einstein Urology. Dr. Lallas completed medical school at Jefferson/Sidney Kimmel Medical College and his urology residency at Duke. After residency, he completed a fellowship at the Mayo clinic in Scottsdale and has been a faculty member at Sidney Kimmel Medical College since 2004. The Hatfield Professorship was originally established in 1944 with the original gift from the estate of Dr. Henry Reed Hatfield (Jefferson/SKMC 1881) in honor of his father. A portrait of Nathan Lewis Hatfield is displayed in the Department of Urology Office suite located in 11 College. Previous Hatfield Professors include Drs. David M. Davis, Theodore Fetter, Paul Zimskind, S. Grant Mulholland and most recently Dr. Demetrius Bagley. Dr. Lallas is the 6th holder of this endowed chair. Jefferson has created more than 100 endowed professorships since the first was established in 1904 in honor of Dr. Samuel Gross.

Year in Review

According to Dr. Mark Tycocinski, past President of Thomas Jefferson University and former Dean of Sidney Kimmel Medical College: “By recognizing Dr. Lallas with an endowed professorship, Sidney Kimmel Medical College and Thomas Jefferson University formally acknowledge his outstanding dedication, consummate skill, and achievements in health care. The endowed professorship ceremony officially bestows the named position, honoring the recipient as well as the benefactor whose generosity makes the position possible. This professorship celebrating the legacy of the Hatfield family, is tied in perpetuity to healing, education, and discovery here at Jefferson. Endowed professorships are among the highest honors faculty can receive.” The external selection committee, chaired by Dr. Greg Kane, Jane and Leonard Korman Professor of Pulmonary Medicine; Chair, Department of Medicine, consisted of former Jefferson/ Sidney

Kimmel Medical College residents and students who held academic appointments in Urology at other medical schools. The committee noted that: “Dr. Lallas embodies all that we value in a faculty member and surgical educator at SKMC and Thomas Jefferson University and is worthy of receiving this endowed professorship recognition.” In addition to the honor of the professorship title, the appointment also provides partial support for non-clinical research, administration and teaching activities.

Research Update

Overactive Bladder (OAB) and the INTIBIATM Study Overactive Bladder (OAB), a common yet often underreported condition, presents unique challenges that require a nuanced understanding and tailored management. OAB is characterized by a spectrum of symptoms, notably urgency, frequency, nocturia, and urge incontinence. These symptoms can significantly impact patients' quality of life, and understanding their intricacies is crucial for accurate diagnosis and effective intervention. First-line treatments for OAB include behavior/lifestyle modifications, second-line treatments include pharmacotherapies, and third-line surgical treatments include chemo-denervation, sacral neuromodulation (SNM), and posterior tibial nerve stimulation (PTNS).

Jefferson Researchers will evaluate the effects of the INTIBIATM device for reducing urine leakage and diminishing the incidence of urinary urge incontinence episodes.

The market for surgical OAB treatments is growing with the introduction of an updated SNM system from Medtronic (Dublin, Ireland) and a new SNM system from Axonics (Irvine, CA). While PTNS may serve as a less invasive method for neuromodulation, it is limited by the need for multiple in-office treatments over several weeks initially followed by perpetual maintenance treatments. Several PTNS devices recently received FDA-approval: eCoin from Valencia Technologies (Valencia, CA) and Revi from BlueWind Medical (Park City, UT). Several additional PTNS devices are undergoing clinical evaluation: Protect PNS (Uro Medical, Boca Raton, FL) and TITAN 2 (Medtronic). At Jefferson, we are growing our benign urology clinical trial portfolio and are participating in the INTIBIATM Pivotal Study (NCT05250908) for an implantable tibial nerve stimulator (Coloplast, Humlebaek, Denmark) with Dr. Patrick Shenot as the Primary Investigator and Oleksander (Alex) Kolesnikov as the clinical research coordinator. This is a prospective, randomized, double-blind, multicenter study to evaluate the safety and efficacy of an implantable tibial nerve stimulator. The purpose of the study is to determine whether the investigational INTIBIATM device can diminish the incidence of urinary urge

Diagram indicating the posterior tibial nerve and the site of the INTIBIATM implant insertion. [Courtesy Wibisono, E., and Rahardjo, H. “Management of overactive bladder review: the role of percutaneous tibial nerve stimulation.” Medical Journal of Indonesia 25 (2017): 245]

incontinence episodes. The INTIBIATM device is surgically implanted in the lower leg and works with the muscles, nerves, and bladder, which control the ability to urinate (see figure). Drs. Patrick Shenot and Paul Chung with Oleksander “Alex” Kolesnikov displaying a certificate recognizing the first INTIBIATM implant at Jefferson.

Jefferson Urology

Research Update

UROLOGY CLINICAL TRIALS The Department of Urology has nearly a dozen clinical trials for bladder cancer, prostate cancer, overactive bladder, erectile dysfunction and several others in collaboration with the Sidney Kimmel Cancer Center. Below is a partial listing of some current Department of Urology Clinical trials with others being added this year. For more information, visit www.jeffersonhealth.org/clinical-trials. For details or to refer a patient, contact Alex Kolesnikov (he/him) Urology Senior Clinical Research Coordinator at Oleksandr.Kolesnikov@ Jefferson.edu. On page 15, we feature details on one of our latest clinical trials for overactive bladder using the investigational INTIBIATM posterior tibial nerve implant.

VPAC Urinary Detection of Prostate Cancer Jeff Trial # 15161 Detection of prostate cancer using voided urine INTIBIATM for Urinary Incontinence and Overactive Bladder -- Jeff Trial # 21824 An investigational device study that will help understand if stimulation of the tibial nerve effects/reduces urinary incontinence in both males and females (see write up below) Evaluation of novel ultrasound techniques to evaluate erectile dysfunction -- Jeff Trial # 25644 This uses various ultrasound techniques to evaluate vasculature and flow of the flaccid and erect penis, as well as a better understanding of penile anatomy IT Matters (Penile prosthesis study) Jeff Trial # 25146 Questionnaire study to assess erectile function at six months post implantation of Penile Prosthesis, demonstrating an improvement in quality of life from baseline. Preservation of Erectile Function with Early Postoperative Application of Low Shockwave Therapy After Nerve Sparing Prostatectomy -- Jeff Trial # 22705 Post-operatively patients will undergo two courses of six LiSWT treatments OR sham treatments within a period of six weeks’ time with a six-week break in between courses, for a total of twelve LiSWT or sham sessions. Bridge Trial for Bladder Cancer Intravesical BCG vs. Intravesical Docetaxel and Gemcitabine in BCG-naïve Patients Jeff Trial # 32604 Patients will be randomized either to receive BCG or Docetaxel and Gemcitabine SunRISE-3 for Bladder Cancer TAR-200 with Cetrelimab vs. Intravesical BCG in Patients with High Risk Non-muscle Invasive Bladder Cancer (NMIBC) Patients receive TAR-200 (intravesical gemcitabine eluting implant) and Cetrelimab or BCG and undergo several months of instillations with cystoscopy, cytology, imaging, and biopsy as needed. 16

Year in Review

Philadelphia Prostate Cancer Biome Project Update In just four years, Jefferson’s Philadelphia Prostate Cancer Biome Project (PPCBP) has emerged as a powerful catalyst for discovery, an incubator for innovation, and a research model for other health systems to follow. As we continue to blaze new trails in our fight against prostate cancer, we built upon two key programs in the PPCBP: an Artificial Intelligence (AI) Program and a Translational Development Program. Over the past year, we launched the Artificial Intelligence Program to examine the pathologic details of prostate cancer and the microenvironment (the “prostate biome”) to better understand how prostate cancer starts, how it spreads, how it is influenced by its environment, and how we can exploit these mechanisms to better detect and treat the disease. We also continued our Translational Development Program aimed at enhancing the connection of clinical care with basic science. One of the goals of this program is to train the next generation of clinicians and translational researchers by providing protected and supported research time, mentorship, and guidance so that they can continue in a research career at Jefferson and beyond. Since its inception, the PPCBP has sought to push the frontiers of prostate cancer science through our Pilot Award Program. Every future standard of care begins as a new idea, and the PPCBP is especially interested in funding proof-of-concept studies and supporting early-career investigators whose outside-the-box research might otherwise go unfunded through traditional sources. To date, our Pilot Award Program has delivered more than $1.97 million in grants to fund innovative new research led by 14 junior and senior investigators at Jefferson and other institutions across Philadelphia. A component of our NCI designated Sidney Kimmel Cancer Center, the Biome is supported by philanthropy from the Martin family. The program is under the direction of Dr. Kevin Kelly, SKMC Chair of Medical Oncology and Dr. Leonard Gomella, SKMC Chair of Urology.

For more information, contact Elena Boroski, Director of Development, Sidney Kimmel Cancer Center, Office of Institutional Advancement by email:elena.boroski@jefferson.edu.

Basic Science Update from the Schiewer Urology Lab The Schiewer Urology Lab was out in force at the March 2023 American Association of Cancer Research (AACR) Advances in Prostate Cancer Research conference in Denver, Colorado. Dr. Matt Schiewer, Assistant Professor of Urology and Cancer Biology, reports that three of the labs abstracts were selected for poster presentations. Details of these presentations of cutting-edge unpublished data are shown in the pictures. The Department is proud of the outstanding work being conducted by the trainees pursuing their PhD thesis work in the lab. Our PhD students are also passionate about community outreach (see page 49). The Schiewer Urology Lab is also pleased to announce the following student milestones achieved in 2023. • Salome Tchotorlishvili, MS, defended her Master’s thesis titled, “Evaluating the combination of cisplatin and PARPi in bladder cancer,” which is being prepared for submission to a peer-reviewed journal and for deposition as a preprint on bioRxiv. •

Candice Bizzaro successfully defended a grant proposal in fulfillment of her PhD qualifying exam and is now a PhD candidate.

•

Moriah Cunningham (PhD candidate) submitted a review article titled, “PARP-ish: PARP and the racial disparity in prostate cancer,” which is now under peer review.

•

Latese Evans (PhD student) successfully completed her year one coursework, including the grueling GC550, which covers a broad and deep range across the spectrum of biomedical science disciplines. She successfully defended her thesis and formally graduated with her master’s degree (see page 49).

•

Michael Xu (SKMC Class of 2024) has been conducting research while doing clinical rotations and preparing for exams. See more about our SKMC medical student Michael and his work on page 63.

The Schiewer Urology Lab also hosted a patient advocate in the lab through the Making Research CLEAR Program through the Sidney Kimmel Cancer Center. The CLEAR (Community Learning and Experience About Research) Program aims to break down the walls between cancer centers and the communities they serve, to increase transparency in the cancer research process and to incorporate the community's voice in cancer research. This year, Dr. Schiewer and his lab group hosted a community member on a lab tour and reviewed the research projects ongoing in the lab and the participant gave lab members critical feedback from the community perspective.

Candice Bizzaro, PhD candidate, exploring the oncogenic role of six-transmembrane epithelial antigen of the prostate in the contect of androgen receptor signaling. Poster Session B, Friday, March 17, 2023

Moriah Cunningham, PhD candidate, Understanding the Role of PARP activity in prostate cancer. Poster Session B, Friday, March 17, 2023

Latese Evans, MS, PhD student, Interplay between PARP and the RB/E2F axis in prostate cancer. Poster Session B, Friday, March 17, 2023 Jefferson Urology

National Meetings

Mid-Atlantic AUA Annual Meeting 2023 by Dr. Costas Lallas, Past President, MA-AUA This year, the MAAUA Annual Meeting was held in historic Colonial Williamsburg, VA, from October 19-21, at the Williamsburg Lodge. The MAAUA president was Dr. Costas Lallas, whose term ended at the end of the meeting. Nestled in the southeast corner of our AUA section, picturesque Williamsburg contains a fully restored colonial town, filled with shops, administrative buildings, and a full complement of in-costume inhabitants living and teaching about 18th-century colonial life. In a standard day, George and Martha Washington and Thomas Jefferson can be seen strolling along Duke of Gloucester Street, the main avenue of Williamsburg. Just adjacent and within walking distance of the town is one of the oldest institutes of higher learning in the country, the College of William and Mary. This family-friendly meeting venue is located within the historic town, and our section took advantage of many of the available settings and backdrops to hold our social events, including a Colonial Theme Night, Night Golf, a 5K Fun Run through town, and a guided tour of Historic Williamsburg. Our educational program was a full three days, during which we had 4 invited speakers, more than 20 panel and plenary sessions, concomitant poster sessions,

and a full-day program for the APP members of our section. Our named speakers were Dr. Glenn Preminger from Duke as our Paul Schellhammer Lecturer and Dr. Paul Andrews from Mayo Arizona as our Hugh Hampton Young Lecturer. Several Jefferson urology faculty were speakers. In addition to updates on more standard clinical topics, including oncology, robotic surgery, and endourology, our Program Committee used significant thought when structuring the three days, taking advantage of some of our in-section specialists who also focus on less common pursuits. Accordingly, we had a panel on global medicine, a series of lectures targeted toward resident education, and talks on lesscommon clinical scenarios, such as transgender medicine and transitioning a pediatric patient into adult management. The Committee Chair was our own Dr. Paul Chung from TJUH, who was responsible for arranging a varied and excellent educational program. The meeting attendance was back to pre-pandemic levels and industry support was at an all-time high. Future Jefferson participation in the MAAUA leadership will include Dr. Lallas as the Immediate Past President and a Nominating Committee member, Dr. Chung as the Young Urologist Committee Chair, and Dr. Mihir

Shah as an at-large member of the Nominating Committee. A complete listing of podium and poster presentations by Jefferson Urology at the 2023 MA-AUA meeting can be found on page 77 under 2023 CONFERENCE PRESENTATIONS.

One MA-AUA plenary session featured a discussion of “Contemporary Management of Fournier’s Gangrene” with moderator Dr. Paul H. Chung, Thomas Jefferson University and speaker Dr. Judith Hagedorn from the University of Washington and the Fred Hutchinson Cancer Center in Seattle, Washington.

The American Urologic Association has eight sections (Mid-Atlantic, New England, New York, Northeastern, North Central, South Central, Southeastern and Western). Jefferson is in the Mid-Atlantic section and our motto is “Small but mighty, proficient but humble.”

Year in Review

1 Dr. Scott Hubosky’s MA-AUA endourology plenary lecture kept everyone’s attention. 2 Dr. Scott Hubosky‘s plenary endourology presentation lecture along with MA-AUA President Dr. Costas Lallas and Dr. Glenn Preminger from Duke, who was the honored “Paul Schellhammer Lecturer.”

3 Dr. Whitney Smith with panelists Dr. Laura L. Giusto, Chesapeake Urology, and Dr. Jacqueline Zillioux, University of Virginia discussing "Hot Topics in FPMRS." 4 Drs. Tricia and Lenny Gomella hosted a Jefferson breakfast at the MA-AUA meeting in Williamsburg in honor of Dr. Lallas’s MA-AUA Presidency. Mid-Atlantic AUA legend Dr. Paul Schelhammer and his wife joined us for the event. 5 Dr. Lallas and Thomas Jefferson in Williamsburg, Virginia. During the Past Presidents and Board dinner with Mr. Jefferson, attendees learned that the smallpox inoculation was discouraged in many of the colonies, including Virginia. That began to change when Jefferson traveled to Philadelphia at age 23 to undergo inoculation. He remained an early and strong advocate for smallpox inoculation in spite of resistance from many individuals and lawmakers. Jefferson Urology

National Meetings

APRIL 28-MAY 1, 2023 The Department of Urology had a strong showing at the 2023 Annual AUA meeting in Chicago held from April 28 to May 1. Jefferson urology meeting participants included faculty, residents, our endourology fellow, Jefferson Urology Scholars and medical students, who participated in our research projects. More than 70 alumni and friends attended our Jefferson Urology/ Canadian Journal of Urology reception. Congratulations to our now PGY4 resident Dr. Maria D'Amico, team captain of the Mid-Atlantic Resident Bowl team AKA "Fournier’s Gang." For the second year in a row, our Mid-Atlantic AUA team has won the national AUA Resident Bowl Championship with Maria participating both years.

Year in Review

DEPARTMENT OF UROLOGY AUA 2023 PRESENTATIONS L. Gomella: EDUCATIONAL PROGRAM– The Evolving Landscape of Advanced Prostate Cancer Treatment: A Guidelines and Case-Based Discussion presented by the AUA in partnership with the Society for Urologic Oncology (SUO) R. Simhal, K. Wang, Y. Shah, P. Chung: MODERATED POSTER – Predictors of Surgical Risk and Outcomes of Gender Affirming Surgery S. Hubosky: EDUCATIONAL PROGRAM– Maximizing New Technological Advances in Ureteroscopy and Associated Instrumentation R. Simhal, K. Wang, M. D’Amico, C. Capella, R. Ragam, Y., J.Y. Leong, A. Murphy, P. Shenot: MODERATED POSTER – Predicting Risk for Patients Undergoing Sacrocolpopexy from Frailty Indexes R. Simhal, K. Wang, M. D'Amico, C. Capella, R. Ragam, Y. Shah, J. Y. Leong, W. Smith, P. Shenot, A. Murphy: MODERATED POSTER – Outcomes and Patient Characteristics for Sacrocolpopexy Performed by Urology vs Gynecology

Y. Shah, H. Goldberg, B.Hu, S. Daneshmand, T. Chandrasekar MODERATED POSTER – Socioeconomic Factors In Metastatic Testicular Cancer Incidence and Outcomes C. Lallas, A. Calvaresi, E. Trabulsi: EDUCATIONAL PROGRAM– Chemotherapy and Immunotherapy for the Urologist and Advanced Practice Provider G. Henry, C. Phillips, J. Wallen, S. Hollenbech, N. Diaz, P. Chung: MODERATED POSTER – Determining Differences in Clinically Infected Versus Noninfectious Biofilm at the Time of Revision Surgery Using Next Generation Sequencing L. Gomella: MODERATOR – Benign Prostatic Hyperplasia: Epidemiology, Evaluation & Medical Non-surgical Therapy A. Calvaresi: EDUCATIONAL PROGRAM– Urologic Care for the Advanced Practice Provider H. Foss, D. Ebbott, Z. Prebay, M. Li, P. Chung: MODERATED POSTER – Utilization of Intracavernosal Injection and Penile Ultrasound in the Evaluation of Erectile Dysfunction and Peyronie’s Disease P. Chung, H. Baris, C. Phillips, E. Chisari, J. Curtis Nickel, J. Parvizi, B. Boursi: MODERATED POSTER–Variation in Urinary Microbiota of Astronauts on a Short Duration Space Flight L. Gomella: EDUCATIONAL COURSE – Genetic Testing in Prostate Cancer: Understanding Clinical Implications for Early Detection and Management of Localized and Advanced Disease

L. Gomella – AUA Honorary Award Presentation (Plenary Session)

1 Mid-Atlantic Resident Bowl team AKA "Fournier’s Gang" led by Captain Dr. Maria D’Amico in the heat of the semi-final round.

2 Dr. Leonard Gomella participated in a panel addressing the role of PSMA-PET scanning in the management of prostate cancer during the AUA meeting in Chicago. Panelists included Phillip J. Koo, MD, division chief of Diagnostic Imaging, Banner MD Anderson Cancer Center in Phoenix, Jason Efstathiou, MD, DPhil, Professor of Radiation Oncology at Harvard, Dr. Gomella and Oliver Sartor, MD Professor of Medicine, Urology, and Radiology at the Mayo Clinic, Rochester, MN. 3 Each year, the Society of Urologic Oncology (SUO) partners with the AUA Office of Education to present a program on the management of Advance Prostate Cancer for urologists. Course Directors are Drs. David Jarrad (Wisconsin) and Michael Cookson (Oklahoma) seen here with Dr. Gomella and the other faculty members: Drs. Steve Boorjian (Mayo), Kelvin Moses (Vanderbilt), Josh Lang (Wisconsin), Kristen Scarpato (Vanderbilt) and Kelly Stratton (Oklahoma). 4 Participants in the Jefferson Urology/ Canadian Journal of Urology International reception during the 2023 AUA Annual Meeting in Chicago. 5 "Fourniers Gang," the Mid Atlantic AUA Residents Bowl National Champions. Urology resident teammates from left to right: Amr Elbarky, West Virginia University; Clinton Yeaman, University of Virginia; Maria D’Amico, Jefferson; Ahmad Alzubaidi, Penn State University; and Mohamed El Gamasy, Tanta Urology Center, Egypt. 6 Attendees at the Jefferson Urology/Canadian Journal of Urology International reception during the AUA in Chicago included Jefferson residency program alumni Drs. Chris Caputo, Kymora Scotland, Victor Kucherov, Ben Rudnick and current resident Dr. Zack Prebay.

Y. Shah, R. Simhal, K. Wang, H. Goldberg, C. Lallas, T. Chandrasekar: MODERATED POSTER – Patient-Specific Predictors of Nephrectomy Complications in T1b-T2 Renal Cell Carcinoma H. Foss, D. Ebbott, Z. Prebay, M. Li, P. Chung: MODERATED POSTER – Evaluating Peyronie’s Disease Treatment Pathways Utilizing the TriNetX Global Database R. Simhal, K. Wang, M. D'Amico, C. Capella, R. Ragam, Y. Shah, J.Y. Leong, A. Murphy, P. Shenot: MODERATED POSTER – Demographics and Outcomes of Bladder Augments in Adults for Neurogenic Bladder A. Calvaresi: EDUCATIONAL PROGRAM– Urologic Care for the Advanced Practice Provider L. Gomella: AUA SYMPOSIUM– PSMA PET in Prostate Cancer: A Case-based Discussion R. Simhal, K. Wang, Y. Shah, D. Simon, J. Mark, Z. Prebay, C. Lallas, L. Gomella, M. Shah: MODERATED POSTER – Stent vs Stent-less Ileal Conduits After Radical Cystectomies: Is There Difference In Early Postoperative Outcomes M. Buck, A. Salib, E. Kloniecke, A. Calvaresi, C. Lallas, L. Gomella, J. Izes: MODERATED POSTER – Comparison of Reduced and Full BCG dosing in The Treatment of Non-Muscle Invasive Bladder Cancer Z. Prebay, H. Foss, D. Ebbott, J. Hyman, M. Li, P. Chung: MODERATED POSTER – Can Patients in Sodium-Glucose Co-Transporter 2 Inhibitors Safely Receive a Urologic Implant? A. Fuselier, R. Griggs, E. Karpman, P. Chung, G. Henry: MODERATED POSTER – Irrisept Washout at the time of Revision Surgery Decreases Tissue Culture Positivity: Single Center Experience Z. Prebay, H. Foss, D. Ebbott, M. Li, P. Chung: MODERATED POSTER – The Risk of Complications, Infections, and Re-Interventions in Men Receiving Artificial Urinary Sphincters, a Global, Prosperity Score Matched Analysis Z. Prebay, H. Foss, D. Ebbott, M. Li, P. Chung: MODERATED POSTER – Propensity Score Matched Analysis of Male Slings and Risk for Failure or Treatment Progression R. Simhal, M. Poluch, Y. Shah, K. Wang, J.Y. Leong, M. Shah, L. Gomella, T. Chandrasekar, C. Lallas: PODIUM – Bowel Preparation Regimens Reduce Sepsis Following Radical Cystectomy with Continent Diversion

Jefferson Urology

National Meetings

Dr. Leonard Gomella with Nurse Practitioner Shandi Husen.

SUNA 2023 The Society of Urologic Nurses and Associates (SUNA) annual meeting was held in Phoenix from October 26-29, 2023. Dr. Gomella, along with Shandi Husen, FNP-C, CUNP Nurse Practitioner, with the Wichita Urology Group, Wichita, KS, they presented a CME/CNE program titled, “Advancing Nursing Practice in Prostate Cancer Management.” The program included didactic lectures and case management scenarios. SUNA is the recognized authority of urologic nursing care and education and sets the standard of urologic education for healthcare providers and patients. SUNA has more than 3,000 nurse, student, technician, & urologic health care professionals and sponsors a variety of national educational conferences throughout the year.

Residents Drs. Maria D’Amico and Courtney Capella presenting a poster at the SWIU 2023 Annual Mentorship Conference.

Society of Women in Urology Mentorship Conference Residents Drs. Maria D’Amico and Courtney Capella attended the Society of Women In Urology (SWIU) Annual Mentorship Conference January 27- 28, 2023, in Scottsdale, AZ, during their PGY-3 year. They both had the opportunity to present a poster with Maria presenting “Perioperative Outcomes for Radical Prostatectomies for Advanced Stage, Node Positive, and Metastatic Prostate Cancer” and Courtney presenting “Preoperative Oral Antibiotic Bowel Regimens with Reduced Rates of Sepsis in Patients Undergoing Radical Cystectomy with Continent Diversion.” Dr. Puneeta Ramachandra from our Pediatric Urology faculty also participated in the mentorship meeting.

New York GU™ 16th Annual Program On Friday, March 10 and Saturday, March 11, Dr. Dan Petrylak Professor of Medical Oncology and Urology at Yale School of Medicine/Yale Cancer Center, and Dr. Leonard Gomella, once again Chaired the New York GU™ 16th Annual Interdisciplinary Prostate Cancer Congress® and Other Genitourinary Malignancies. The program continues the tradition of providing clinicians with valuable knowledge and confidence to maintain state-of-the-art care and optimize outcomes for patients with genitourinary (GU) malignancies focusing on prostate, bladder and kidney cancer. In 2023, the New York City based program offered both in-person and virtual participation. Dr. Gomella arranged for all Jefferson Medical Group Urologists, Jefferson and Einstein residents, along with our Jefferson Health urology APPs, to receive complimentary registration for both options to participate. The 17th Annual Program is scheduled for March 8-9, 2024 in New York. Program details can be found at hwww.gotoper.com/courses/new-york-gu. Drs. Gomella and Petrylak, New York GU™ program Chairs. 22

Year in Review

Global Engagements & International Affairs

2023 SIU in Istanbul, Turkey

Dr. Gomella with Kinju Adhikari, MBBS, (FCPS) from Bengaluru, India and Gokul Vignesh Kanda Swamy, MBBS from Swansea, South Wales, UK. They conducted an educational program titled, “Basic Concepts and Clinical Applications of Genetic and Genomic Testing for Urologists.”

The 43rd Congress of the Société Internationale d’Urologie (SIU) met in Istanbul, Turkey in October 2023. Drs. Scott Hubosky and Leonard Gomella attended as invited faculty members. Dr. Gomella participated in several different lectures, panels and resident mentoring sessions during the SIU.

Dr. Ehab Tawfiek former Jefferson endourology fellow and Dr. Scott Hubosky at the 2023 SIU in Turkey presented an “Advanced Ureteroscopy” course.

Dr. Nerli conducts urinary shed cell detection work in collaboration with Drs. Mat Thakur and Leonard Gomella. Dr. Nerli’s focus has been bladder and prostate cancer detection in the urine.

Dr. Hubosky gave two presentations as part of an Instructional Course titled “Advanced Ureteroscopy.” His lectures included strategies on achieving upper urinary tract access for ureteroscopy in challenging clinical situations, treatment of upper urinary tract obstruction with retrograde ureteroscopic techniques and avoidance of complications during ureteroscopy. Other Jefferson alumni participating in this instructional course were Dr. Ehab Tawfiek, former Jefferson fellow who worked with Dr. Bagley, from Minia University in Egypt and former resident Dr. Michael Grasso of New York Medical College. One of Jefferson’s international VPAC research collaborators, Dr. Rajendra Nerli from KLE in Belgaum, India, received a Best ePoster award (pictured right) at the SIU in Turkey.

Jefferson Urology

Global Engagements & International Affairs

President of the Dual MD Jefferson and Cattolica University in Rome Visits the Department of Urology

Giovanni Gambassi, MD, Chair of Internal Medicine at Gemelli Hospital (Rome) and President of the Dual MD Degree program with Jefferson and Cattolica University in Rome

(pictured above left), visited the Department of Urology along with Dr. Ignazio Marino, Professor of Surgery, SKMC and Executive Vice President for International Innovative Strategic

Ventures (pictured above right). The visit was to discuss the potential for various joint programs including clinical urology rotations for Cattolica medical students.

Poznan University of Medical Sciences (PUMS) Drs. Tricia and Lenny Gomella (pictured) were invited to lecture at the Poznan University of Medical Sciences (PUMS) in Poznan, Poland. PUMS has a two-track medical school, one for English speaking students and one for Polish students. Each year, they educate up to 100 English speaking students, mostly U.S. nationals and have a U.S. match rate of more than 80%. Their facilities are first class and they recently opened a state of the art simulation center. PUMS leaders are aware of the international programs that Jefferson has around the world and are interested in working with Jefferson on a variety of educational programs. 24

Year in Review

KLE Student Exchange 2023 Our Jefferson India Center is located in Belgaum (or Belagavi), a city in the southwest Indian state of Karnataka. The center was developed in collaboration with KLE University, an institution spanning a history of more than 100 years and ranked among the top of India’s universities. Each year, Dr. Richard Derman, Vice Provost for Global Affairs at Thomas Jefferson University and Professor, Obstetrics & Gynecology, working with Parth D. Lalakia, MPH, Senior Research Associate Office of Global Affairs have promoted the interactions between our department and the Jefferson India Center that includes both research and educational activities. This year, Jefferson hosted 4 KLE medical students including one student interested in Urology.

Dr. Gomella presented the 4 visiting KLE students with copies of his medical student book “The Clinicians’ Pocket Reference” 12th edition.

23rd Asia Pacific Prostate Conference Cairns, Australia

The Australian Prostate Center hosted the 23rd Asia Pacific Prostate Conference in Cairns, Australia, from August 18-20, 2023. Over many years, the conference has grown to now be one

Transrectal ultrasound simulator.

of the largest comprehensive prostate cancer meetings in the world. Drs. Tony Costello and Phil Dundee from the Australian Prostate Center in Melbourne were the conference organizers and invited Dr. Leonard Gomella to participate along with other international faculty members. In addition to panel discussions, Dr. Gomella gave a variety of lectures on prostate cancer topics such as the role of precision medicine, family history and genetic risk and the role of genetic testing for screening and active surveillance.

One of the APCC panels addressed the topic of Early Stage Prostate Cancer. Participants included (see photo) Drs. Peter Swindle, Queensland Prostate Clinic, Dr. Niall Cocoran, University of Melbourne, Dr. Tony Costello, Australian Prostate Center, Dr. Kiristen Greene, Chair of Urology, University of Virginia, Dr. Gomella, Dr. Dan Spratt, Chair of Radiation Oncology, University Hospitals, Cleveland and Dr. Henry Woo, Professor of Urology at the College of Health and Medicine at the Australian National University in Sydney.

Point of care ultrasound station. Jefferson Urology

Visiting Professors and Guest Lecturers 2023 Howard B. Goldman, MD, FACS Paul D. Zimskind, MD, PhD, Visiting Professor, Cleveland Clinic Dr. Howard B. Goldman is a Professor on the faculty of the Cleveland Clinic Lerner College of Medicine and an expert in quality and patient safety who serves as the Institute Vice Chairman for Quality at the Glickman Urologic Institute. He is actively involved in the training of fellows and residents, including serving as the Fellowship director for Female Pelvic Medicine and Reconstructive Surgery (FPMRS) in the Department of Urology at the Cleveland Clinic. Dr. Goldman’s interests are in the medical and surgical treatment of urinary incontinence and other types of voiding dysfunction, neuromodulation, prolapse repair, complex reconstructive female urologic surgery, robotic surgery and neurourology. His contributions to the literature have been prolific, including author of over 250 articles and book chapters, editor of three textbooks and panel member for a number of standardization, guidelines and

best practice statement panels. He has been at the forefront of outpatient robotic surgery within FPMRS. Within the AUA he has been on the SUI Guidelines and Urodynamics guidelines committees. Established in 2012, this biennial Paul D. Zimskind Visiting Professorship is to honor the urodynamics legacy of Dr. Paul Zimskind who served as sixth Chairman of the Department of Urology serving from 1967 to 1976. The program is made possible through the dedication of Dr. Max Koppel (SKMC 57) and Dr. Michael Lewitt (SKMC 74). During his Paul D. Zimskind Visiting professorship on March 22-23, 2023, Dr. Goldman supervised a journal club for residents discussing challenging cases in female pelvic reconstruction and gave a grand rounds lecture, “OAB Meds – Reason for Concern? What Else is in the Pipeline?”

Visiting professor Dr. Howard Goldman with Dr. Max Koppel and Jeffery Zimskind, Dr. Paul Zimskind’s son.

Stephen A. Boorjian, MD, FACS David M. Davis, MD, Visiting Professor 2023, Mayo Clinic Dr. Stephen A. Boorjian is the Carl Rosen Professor of Urology, Chair of the Department of Urology, and the Director of the Urologic Oncology Fellowship at Mayo Clinic. He received his MD from Harvard Medical School, and was a resident in Urology at New York Presbyterian Hospital-Weill Cornell Medical Center. He subsequently completed a fellowship in Urologic Oncology at Mayo Clinic. Dr. Boorjian has co-authored over 450 manuscripts and book chapters, and was recognized as “Teacher of the Year” in Urology for 2012 by the Mayo Clinic Fellows’ Association.

In addition, he received the Young Urologist of the Year award from the AUA in 2014 and 2018, as well as the 2016 Young Investigator Award from the Society of Urologic Oncology. Previously, he has served as a member of the NCCN Guidelines Panels for Bladder Cancer and Penile Cancer, the AUA Non-Muscle Invasive Bladder Cancer Guideline Panel, as co-chair of the AUA Microhematuria Guideline Panel, and as Vice Chair of the Clinically Localized Prostate Cancer Guideline Panel. Clinically, his practice includes a breadth of all malignancies in urologic oncology.

As the year-end DM Davis Visiting Professor on June 15 and 16, 2023, he was involved in our graduation activities including a dinner with the residents, interactive case presentations and our year-end award ceremonies. His lectures included “Does Surgery Still Have a Role in High Risk Prostate Cancer?” and “Cost Effectiveness Analysis in Urologic Oncology: A Methodology to Comprehensively Assess the Impact of Therapy.”

Dr. Boorjian (pictured 5th from left) and attendees at the 2023 DM Davis Visiting Professor program.

Year in Review

Tracey Krupski, MD, MPH, Visiting Professor, University of Virginia Tracey L. Krupski, MD, MPH, is the Jay Y. Gillenwater Professor of Urology University of Virginia, in Charlottesville, Virginia. As a visiting professor, Dr. Krupski participated in two educational sessions. On Wednesday evening, March 1, she gave an interactive presentation with the residents titled, “Adventures or Misadventures in Cystectomy Care.” She challenged the residents to provide management strategies on real life scenarios she has encountered in her urologic oncology practice that focuses on bladder cancer. For grand rounds on March 2, Dr. Krupski discussed her pioneering and award-winning work on the use of tele-cystoscopy in the state of Virginia to allow urologic care in underserved parts of the state. In addition to her many clinical and academic responsibilities, she recently completed her term as President of the Mid-Atlantic Section of the AUA when she passed the gavel to Dr. Lallas.

Pictured: Dr. Krupski and urology residents.

Joel Sheinfeld, MD, Guest Lecturer Memorial Sloan Kettering Cancer Center Dr. Joel Sheinfeld, the Florence & Theodore Baumritter/Enid Ancell Chair in Urologic Oncology, has served as Vice-Chairman/Deputy Chief of Urology at Memorial Sloan Kettering Cancer Center for the past 20 years, and Director of the Urology Fellowship since 1994. He is also professor of Urology at Weill Medical College of Medicine, Cornell University.

Dr. Sheinfeld presented grand rounds virtually in April 2023 from Memorial Sloan Kettering Cancer Center in New York. He is shown here with 2023 Chief Residents Drs. Anthony Tokarski, Andrew Salib and Edward Kloniecke.

Dr. Sheinfeld specializes in the management of patients with genitourinary cancers with particular expertise in the clinical care of patients with testicular cancer. He has performed approximately 2,500 RPLNDs over the past 30 years, currently doing about 100/year. He has authored or co-authored more than 350 papers, chapters and editorials on testicular cancer, and has spoken frequently on the topic at national and international meetings. He served as faculty director for the AUA course on testicular cancer for 20 years. On April 20, 2023, Dr. Sheinfeld presented a Jefferson Urology Grand Rounds lecture on “Optimizing the Retroperitoneal Lymph Node Dissection for Testicular Cancer” and shared many subtle yet essential points about the operation.

Ruchika Talwar, MD, Guest Lecturer, Vanderbilt University Dr. Ruchika Talwar completed her Urology training at the University of Pennsylvania and is currently a Urologic Oncology Fellow at Vanderbilt. As an AUA H. Logan Holtgrewe Legislative Fellow, she expanded her interest and expertise in health policy and regularly publishes on the topic. Dr. Talwar’s grand rounds September 14, 2023, presentation was titled, “Advocacy for the Urologist, from your Clinic to Capitol Hill.” Chief Residents Drs. Radhika Ragam and Halle Foss with Dr. Ruchika Talwar. Jefferson Urology

Visiting Professors and Guest Lecturers 2023 Michael D. Stifelman, MD, Guest Lecturer Hackensack University Medical Center

Masaya Jimbo, MD, PhD, Guest Lecturer University of Utah

Dr. Michael Stifelman with Chief Residents Drs. Radhika Ragam and Halle Foss.

Dr. Adam Metwalli, grand rounds speaker Dr. Masaya Jimbo and Dr. Irvin Hirsch.

Michael D. Stifelman, MD, is Chair of Urology at Hackensack University Medical Center, Director of Robotic Surgery Professor at Hackensack Meridian Health, and Founding Chair of Urology, Hackensack Meridian School of Medicine. An internationally recognized pioneer and leader in robotic urologic oncology and upper tract urinary reconstructive surgery, Dr. Stifelman has performed more than 4,000 robotic procedures and pioneered more than a dozen minimally invasive surgical techniques. His team was among the first in the nation to use the single port robotic surgical system after FDA approval in 2018. Dr. Stifelman joined Hackensack UMC in 2016 from NYU Langone Medical Center in New York, NY, where he was professor of Urology, NYU School of Medicine and director of the Robotic Surgery Center. Dr. Stifelman presented Grand Rounds in person on September 28, 2023, on “Single Port Robotics.”

Dr. Masaya Jimbo presented our grand rounds lecture on Thursday, November 16, 2023. Dr. Jimbo did his undergraduate studies at the University of Pennsylvania with a BA in Biochemistry (2007) and an MS in Chemistry (2008). He graduated from Jefferson/Sidney Kimmel Medical College in 2017 with an MD as well as a PhD in Cell and Developmental Biology working in the laboratory of Dr. Jonathan Brody. Next, he completed his urology residency at the Mayo clinic in Rochester, Minnesota, and is currently an Andrology fellow at the University of Utah in Salt Lake City. His grand rounds presentation was titled, “The role of TGF-beta1 Signaling in Klinefelter syndrome related testicular fibrosis and germ cell loss.” The lecture provided clinical diagnosis and management approaches for Klinefelter syndrome as well as a discussion of this basic science research he is doing as an Andrology fellow.

Stacy Tanaka, MD, MS, FAAP, FACS William Ferris, MD, Memorial Lectureship, University of Alabama at Birmingham Stacy Tanaka, MD, MS FAAP, FACS is Professor and Chief of Pediatric Urology, at the University of Alabama at Birmingham. As part of her William Ferris MD Visiting Professorship, she gave a grand rounds at Jefferson on Thursday October 12, 2023 titled “AUA publications: an insider perspective (What I’ve learned so Far).” For more details on Dr. Tanaka and her entire visiting professor program, please see News from the Division of Pediatric Urology on page 38. Dr. Stacy Tanaka at Jefferson. Colleagues in attendance for her grand rounds presentation include (left to right) Drs. Puneeta Ramachandra, Radhika Ragam, Keara DeCotiis, Stacy Tanaka, Brian Calio, Halle Foss, Sonny Figueroa and Pat Casale.

Year in Review

Edward M. Schaeffer, MD, PhD Northwestern University 2023 Brownstein Visiting Professor

David M. Davis Visiting Professor 2024

Dr. Leonard Gomella with Dr. Kenny Brownstein and our 2023 Brownstein visiting professor, Dr. Ted Schaeffer.

Chief Residents Drs. Ragam, Foss and Calio with Dr. Schaeffer after his grand rounds presentation “Prostate Cancer 2024: Is this the year genomics finally takes center stage?”

Edward “Ted” Schaeffer, MD, PhD, is the Harold Binstein Professor and Chair, Department of Urology, Feinberg School of Medicine at Northwestern University in Chicago. He is also Program Director of the Genitourinary Oncology Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. Dr. Schaeffer is a clinically active urologist with a specialized practice in prostate cancer. He has published more than 400 peer-reviewed publications emphasizing at-risk populations, diagnosis, treatment outcomes, and the molecular biology of lethal prostate cancer. His discoveries have advanced the understanding of biologic differences in prostate cancers in men of African descent, and molecular features that influence metastatic risk. Dr. Schaeffer is a pioneer in robotic prostatectomy who has made modifications that preserve

continence and sexual function. He is Chair of the National Comprehensive Cancer Network (NCCN) Prostate Cancer Guidelines Committee and participates in the National Cancer Institute and Genitourinary Steering Committee. Dr. Schaeffer is a member of both the American Association of Genitourinary Surgeons and the Clinical Society of Genitourinary Surgeons. Dr. Schaffer was our 12th Annual P. Kenneth Brownstein, MD Visiting Professor on November 1 and 2, 2023. On Wednesday evening, Dr. Schaeffer presented illustrative cases to our residents on the issues surrounding screening and management of men with prostate cancer. His Brownstein lecture was titled, “Prostate Cancer 2024: Is this the year genomics finally takes center stage?”

We are pleased to announce that our DM Davis Visiting Professor in June 2024, will be Professor Olivier Traxer, MD, MS. He is Professor of Urology and Chairman of the Urology Department, Sorbonne University, Tenon Hospital in Paris, France. Dr. Traxer in an internationally recognized expert in endourology and the management of kidney stones. He has received numerous awards, and was President of the World Congress of Endourology in Paris 2018. Jefferson Urology

New Faculty Welcome New Jefferson Urology Faculty Dr. Metwalli has published more than 70 research manuscripts in peer-reviewed journals and has contributed to dozens more as a participant in the Cancer Genome Atlas Research Network. He has authored over 15 book chapters on topics ranging from penile cancer, kidney cancer, adrenal diseases, palliative care, informed consent and the Food and Drug Administration (FDA). Dr. Metwalli is actively involved in clinical trials research; he was the principal Investigator for a Phase II clinical trial evaluating a novel small molecule radiotracer in patients with clear cell kidney cancer, the PI for a multi-institutional DOD concept award investigating the genomics of papillary kidney cancer in patients of African descent, and he has been co-investigator on numerous other trials.

DR. ADAM R. METWALLI

Dr. Adam R. Metwalli joins Jefferson Urology as Clinical Professor of Urology, Sidney Kimmel Medical College after nearly 5 years as a Professor and Chief of Urology at Howard University Hospital in Washington, DC. Prior to that, he was the primary kidney surgeon at the National Cancer Institute in Bethesda, Maryland for over 7 years. Dr. Metwalli is a urologic oncologist trained in robotic surgery and specializing in cancers of the kidney, prostate, bladder, penis, and testis. He attended medical school at Wake Forest University in North Carolina and completed urology residency at the University of Oklahoma Health Science Center, Oklahoma City. In addition, he did a Urologic Oncology Fellowship at the University of Texas MD Anderson Cancer Center and an additional year as an Oncology Fellow at the NCI. After a brief period in private practice, Dr. Metwalli joined the NCI Urologic Oncology Branch in Bethesda, Maryland (see page 4 for more on the “Jefferson Urology and the NCI Connections”). While an attending physician at the NCI, he expanded the use of robotic surgery in the treatment for multifocal kidney cancer as well as for repeat and salvage renal surgery. He also established a collaboration between the Center for Prostate Disease Research (CPDR) at Walter Reed Military Medical Center and developed extensive experience in MRI fusion biopsy techniques. As a result, Dr. Metwalli developed a national and international reputation and has been asked to speak on the surgical management of urologic cancers.

Year in Review

Dr. Metwalli is also involved in health education, successfully completing the Harvard-Macy Institute program for health educators as part of his goal to revamp the urology education curriculum and restore the urology residency training program at Howard. He will see both general urology and urologic oncology patients in Center City and at the Navy Yard and will be involved in our SKCC clinical and basic science research initiatives. He is co-Director of our new Prostate Cancer Focal therapy Program and will participate in our Small Renal Mass Clinic in the SKCC.

DR. PAUL BLOCH

Dr. Paul Bloch is a board-certified urologist with clinical interest in general urology and men’s health. He joins our Department as an Assistant Professor. A native of South Jersey, he graduated from Haverford College with a degree in Biology and earned his medical

degree from Jefferson Medical College (now Sidney Kimmel Medical College). Dr. Bloch completed his surgery internship and urology residency at the University of Tennessee Health Science Center in Memphis. After several years in private practice in South Jersey, Dr. Bloch was interested in returning to an academic practice setting. He has published articles in peer reviewed journals across multiple urology disciplines and is a member of the American Urological Association. Dr. Bloch will be seeing patients in Center City and South Jersey at our new office location in Jefferson’s Cherry Hill Hospital. He has recently been certified to perform Aquablation™, a minimally invasive surgical procedure that uses a robotic imageguided high-pressure water jet to precisely destroy excess prostate tissue to relieve BPH symptoms. DR. PASQUALE “PAT” CASALE returns to Jefferson and Sidney Kimmel Medical College as Professor of Urology in our Division of Pediatric Urology. He will be primarily at Nemours Children’s Health in Wilmington, Delaware where he will DR. PASQUALE CASALE be involved in our student and resident rotations. Dr. Casale completed his urology training at Jefferson in 2002. After a fellowship at Seattle Children’s Hospital, he began a series of academic appointments in Philadelphia, New York, and Florida. He has distinguished himself as a leader in robotic surgery in the pediatric population. According to Dr. Casale, “I am thrilled to return to the Jefferson family. My exceptional training as a resident here in the early days of urologic laparoscopy with Drs. Gomella, Strup and others, as well as my training with Dr. Bagley, set the stage for my further development of minimally invasive robotic assisted and endoscopic surgery in children pioneering procedures once thought not possible in the pediatric population. I am excited to return to teach at the program that laid the foundation for my career.” Read more about Dr. Casale in News from The Division of Pediatric Urology on page 36.

Faculty Spotlight: Kenneth Brownstein, MD

Steps Out of One Jefferson Role Into Another

By Lisette Hilton From his earliest memories, P. Kenneth Brownstein, MD, knew he was destined to become a doctor. It was a profound calling that led him on an incredible, five-decade long journey in Jefferson’s Department of Urology, forging a legacy of excellence in teaching and clinical care. Dr. Brownstein earned his medical degree at Drexel University, where he received the Surgery Award from his graduating class and was a member of the Alpha Omega Alpha Honor Society. His decision to specialize in urology crystallized during his surgical residencies at UCLA Harbor General Hospital and the University of California San Diego Medical Center in the early 1970s. He became intrigued by the exacting nature of the specialty. “Urologists are required to do very specific, creative procedures of the urinary tract,” Dr. Brownstein explains. “The precision and innovation of them appealed to me.” In 1972, Dr. Brownstein came to Jefferson for a residency in urology, and he has been here ever since. During that time, he has achieved significant milestones, including being part of Jefferson’s original kidney transplant team, where he would participate for 25 years. “I worked closely with the vascular surgeons—I would harvest the donated kidney and connect the bladder,” he recalls. “Over the years, I was fortunate to witness dramatic improvements in surgical technique and medical treatment of transplant recipients, which resulted in amazing improvements in outcomes. Early in his tenure, he established his reputation as a gifted educator, earning the award in 1975 for Best Teaching Resident of Thomas Jefferson University Hospital and its affiliates. “Being able to influence the lives and careers of students is incredibly gratifying; this was one of the highest honors of my career,” Dr. Brownstein says. Dr. Brownstein’s multifaceted career as a surgeon, clinician, mentor, educator, and leader earned him many accolades. He served as the president of the medical staff at Jefferson in the 1990s and received the Department of Urology Distinguished Alumnus Award in 2004. At the 2008 Jefferson Gala, he received the Achievement Award in Medicine, Jefferson’s most prestigious honor. In 2018, he was invested as the Harold A. Honickman Physician Director of Jefferson Signature Services, a role he still holds. Additionally, he has authored numerous publications in the field of urology. In 2012, the Department of Urology established the annual Brownstein Visiting Professorship in his honor (see page 29 for the 2023 Brownstein Professor).

I feel so strongly for Jefferson, it's been my whole life.

Although he has transitioned away from direct patient care, his impact remains undiminished. He now serves as a faculty member supporting urology philanthropy in the Office of Institutional Advancement. In addition, he plays a pivotal role on the Admissions Committee of the Sidney Kimmel Medical College. What stands out most for Dr. Brownstein during his time as a urologist at Jefferson are the close relationships he forged with his patients. “I’ve had some patients whom I’ve taken care of for more than 40 years or more,” he says. “Many of them have become personal friends.” While Dr. Brownstein has retired from surgery and patient care, his commitment to Jefferson endures. “I feel so strongly for Jefferson,” he says. “It has been my whole life.” Today, when not supporting Jefferson and the Department of Urology, Dr. Brownstein finds joy in spending time with his family, including three children, eight grandchildren, and two great-grandchildren.

Jefferson Urology

Faculty Notes Dr. Leonard Gomella Receives AUA Award At the 2023 American Urological Association Annual Meeting in Chicago, Dr. Leonard Gomella, Chair of Urology at Sidney Kimmel Medical College, was selected by the AUA Board of Directors for the “Honorary Membership” Award. Dr. Raju Thomas, AUA Immediate Past President and Urology Chair at Tulane, noted that Dr. Gomella received this honor for “his exemplary contributions and leadership in the field of Urologic Oncology.” The American Urological Association offers the “Honorary Membership” Award for scientists and distinguished urologists who have achieved prominence in urology. Previously, Dr. Gomella received a “Distinguished Contribution Award” from the AUA for his long-term contributions for publications that support medical student education. Drs. Leonard Gomella and AUA Past-President Dr. Raju Thomas.

Dr. Gomella received this honor for “his exemplary contributions and leadership in the field of Urologic Oncology.”

SNMMI Award in Honor of Dr. Thakur The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has established the Lalita and Mathew (Madhukar) Thakur Award. The award is in recognition of the exceptional and long-term translational research in the field by Dr. Mat Thakur, Professor of Radiology, Radiation Oncology and Urology. The inaugural award was presented to Dr. Hanwen Zhang of NIH (now at the Mallinckrodt Institute of Radiology, Washington University, St. Louis). The presentation was during the SNMMI annual meeting in Chicago on June 25, 2023, by Drs. Thakur and Catherine Cutler, the President Elect of SNMMI.

Dr. Zhang receiving the Lalita and Mathew (Madhukar) Thakur Award from Drs. Catherine Cutler (President elect of SNMMI) and Mat Thakur.

Congratulations to Drs. Whitney Smith and Patrick Gomella Drs. Gomella and Smith achieved specialty certification this year with the American Board of Urology with our Abington Urology office staff celebrating their achievement. Board certification is considered a major professional accomplishment in our field. All board-certified urologists are trained and qualified to evaluate and treat all patients with urological disorders. Both of our Assistant Professors have advanced fellowship training. Patrick completed a urologic oncology fellowship at the National Cancer Institute in Bethesda, Maryland and Whitney was a female urology fellow at Wake Forest in Winston-Salem, North Carolina. Although there is no further board certification in specialty areas such as urologic oncology, Dr. Smith is now eligible to obtain an additional board certification in Female Pelvic Medicine and Reconstructive Surgery. In addition, Dr. Smith has been appointed DEI Faculty in the Office of Diversity, Equity, and Community Engagement, Sidney Kimmel Medical College, and Dr. Patrick Gomella will be Co-Director of our new SKCC Department of Urology Focal Therapy Program along with Dr. Adam Metwalli (See page 44). 32

Year in Review

MIHIR SHAH, MD Dr. Shah, Assistant Professor of Urology, was nominated and approved by the Board of Directors to be the co-chair for Mid Atlantic AUA Resident Day 2024 and will then serve as the Program Chair for MA-AUA Resident Day 2025. Locally, Dr. Shah has been appointed by the SKMC Committee on Governance to serve as a member of the Diversity Equity and Inclusion Committee for a two-year term beginning in July 2023. Dr. Shah participated in a popular Doximity and Jefferson Health posting addressing questions and answers about prostate HoLEP surgery for benign enlargement (www.jeffersonhealth.org/your-health/living-well/great-surgical-resultfor-enlarged-prostate-after-years-of-discomfort). PAUL CHUNG, MD, FACS SELECTED FOR AUA LEADERSHIP PROGRAM Congratulations to Dr. Paul Chung, Associate Professor of Urology, on his selection for the AUA Leadership Program. The AUA Leadership Program is designed for urologists who have demonstrated leadership skills within organized medicine and who wish to further develop these skills to become the AUA leaders of tomorrow. This highly competitive program selects applicants from each AUA Section to participate in the year-long program that includes a leadership training weekend, group projects with mentors, participation in the Annual Urology Advocacy Summit, networking events at the AUA Annual Meeting, and more. DEBORAH GLASSMAN, MD, FACS Dr. Deb Glassman is now the head of the Advanced Practice Provider (APP) Committee in the Department of Urology. Working with our APP team and other physicians, she is charged with ensuring that our PAs and NPs are providing appropriate levels of care and are engaged in all Departmental educational activities such as grand rounds, Visiting Professors and educational conferences. She also serves as the liaison with Jefferson Health’s Physician’s Assistant Programs supporting their education mission (see page 64). Her telehealth research has continued after the pandemic, with a focus in the area of its influence on decision-making in oncologic treatment. She was again elected a Philadelphia Magazine “Top Doc” as well as recognized as an outstanding female physician by Castle Connolly. Dr. Glassman is a certified yoga instructor and conducts yoga sessions for our residents several times a year.

JEANNE LLENADO, DO, FACOS Dr. Llenado has been appointed Vice Chair for Regional Urology in the SKMC Department of Urology. In addition, she will become a member of our newly established enterprise Jefferson Health Urology Council. In 2023 Dr. Llenado received a Dean’s Award for Excellence in Teaching (see page 34).

MATT SCHIEWER, PhD Matt Schiewer, PhD, Assistant Professor and Vice Chair for Basic Science in the Department of Urology, was involved in the development of a clinical trial (NCT 05501548) that opened and is recruiting patients. This is a Phase II study of the PARP inhibitor olaparib in combination with IV ascorbate (Vitamin C) in castration-resistant prostate cancer. The study PI is Dr. Channing Paller at Johns Hopkins University and is based on Dr. Schiewer’s laboratory results that have been preprinted on bioRxiv and are currently undergoing revisions after peer review (doi: https:// doi.org/10.1101/2023.03.23.533944 J. RYAN MARK, MD, FACS, INDUCTED INTO THE AMERICAN COLLEGE OF SURGEONS On October 22, 2023, Dr. J Ryan Mark was inducted as a Fellow of the American College of Surgeons at the Clinical Congress held in Boston, MA. Dr. Mark is Assistant Professor, Vice Chair for Clinical Research and Director of Clinical Trials in the Department of Urology. In addition, he serves as Medical Director, Sidney Kimmel Cancer Center Biorepository. Founded in 1913, the American College of Surgeons promotes the highest standards for American surgeons. The professional destination FACS refers to Fellow in the American College of Surgeons can now be included in Dr. Mark’s professional title.

Jefferson Urology

Faculty Notes Urology Faculty Teaching Awards DR. SCOTT G. HUBOSKY Dr. Hubosky has received the Department of Urology Residents Teaching award for 2023. The awardee is chosen annually by the residents in recognition for outstanding resident and student education both in the operating room, in the clinic and during conferences. Dr. Hubosky is the Demetrius H. Bagley Jr. MD Professor and Vice Chair Quality Improvement & Safety in the Department of Urology. In addition to his enterprise role for Urology Quality Improvement & Safety, he is Director Division of Endourology and Co-Director our Endourology Society approved Fellowship Program in Endourology & Laparoscopy. Dr. Scott Hubosky, the Demetrius Bagley Professor of Urology receiving the 2023 residents teaching award from graduating Chief Residents Drs. Anthony Tokarski, Edward Kloniecke, and Andrew Salib.

DOLORES BYRNE, PhD Dr. Dolores Byrne, Assistant Professor, Department of Urology, received the College of Life Sciences Award for Outstanding Teaching in 2023. In addition to her contributions to the Department of Urology, Dr. Byrne is the Director of Jefferson’s Post baccalaureate Pre-Professional Program (P4). The program is designed for individuals seeking to complete their basic science requirements in preparation for entrance to professional school. The award recognizes her long term commitment to teaching excellence for the participants in the P4 program. (See page 72.) 34

Year in Review

DRS. PATRICK SHENOT AND JEANNE LLENADO Congratulations to Drs. Pat Shenot and Jeanne Llenado on their Sidney Kimmel Medical College faculty awards. Dr. Shenot was recognized for the SKMC Outstanding Clinician Award for Surgery and Surgical

Subspecialties. Dr. Llenado received a Dean’s Award for Excellence in Teaching. The Awards were presented at a ceremony on Thursday June 29, 2023, by Dr. Mark Tykocinski, former TJU President and past SKMC Dean.

Drs. Schiewer and Gomella Serve as CDMRP Panelists

The CDMRP originated in 1992 via a Congressional appropriation to foster novel approaches to biomedical research in response to the expressed needs of its stakeholders-the American public, the military, and Congress. The CDMRP fills research gaps by funding high impact, high risk and high gain projects that other agencies may not venture to fund.

The program encompasses breast, prostate, and ovarian cancers, neurofibromatosis, military health, and other specified areas. For the 2023 program cycle, Jefferson Department of Urology faculty members, Drs. Matt Schiewer and Leonard Gomella, were invited as panel members to review the grants submitted to the DODCDMRP prostate cancer program.

Dr. Kevin Kelly Reports on Major Prostate Cancer Clinical Trial Interim results from a first in man trial show that xaluritamig (AMG 509) demonstrated promising efficacy in patients with heavily pretreated metastatic castrationresistant prostate cancer (mCRPC). The findings were presented at the European Society for Medical Oncology (ESMO) Congress 2023 in Madrid, Spain and published in Cancer Discovery by Dr. Kelly, Professor of Medical Oncology and Urology. Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is expressed in most prostate tumors and at higher levels in mCRPC (metastatic castrate resistant prostate cancer). Xaluritamig is a bispecific T-cell engager (BiTE) designed to redirect T cells to kill prostate cancer cells that express STEAP1 and is less technically burdensome than CAR T-cell therapy (taking patients cancer fighting T cells and genetically manipulating them in the lab).

Dr. Kelly’s full interview can be found at: https://guoncologynow.com/page/ uromigos-prostate-cancer.

Congratulations to the following members of the SKMC Department of Urology for being named Philadelphia Magazine “Top Doctors” for 2023. Deborah T. Glassman Leonard G. Gomella Joseph K. Izes Costas D. Lallas Alana M. Murphy Patrick J. Shenot Exceptional Women in Medicine 2023 This is a special Castle Connolly designation recognizing outstanding female physicians for their contribution to the advancement of healthcare. Deborah T. Glassman Alana M. Murphy The following Jefferson Health Urologists who are members of our Jefferson Medical Group were also recognized as 2023 Top Doctors. Philip H. Abbosh Howard Altman Lee M. Blatstein Cadence A. Kim David J. Kraman Marc Lavine Edouard J. Trabulsi

Jefferson Urology

News from Division of Pediatric Urology Nemours Children’s Health Delaware By T. Ernesto “Sonny” Figueroa, MD

WELCOME AND FAREWELL The Division of Urology at Nemours and the Department of Urology at Jefferson are extremely pleased to welcome Dr. Pasquale “Pat” Casale. Dr. Casale completed his urology residency at Thomas Jefferson Dr. Pat Casale Professor of Urology University Hospital and his pediatric urology fellowship at Seattle Children’s Hospital and Medical Center. In 2004, he joined the Department of Pediatric Urology at the Children’s Hospital of Philadelphia as Assistant Professor of Surgery (Urology) and was promoted to Associate Professor of Urology in 2011. Drawing upon the superb training in Endourology that he received at Jefferson, Dr. Casale applied these concepts to pediatric urology early in his career. At CHOP, he introduced the approach of minimally invasive pediatric urological surgery, including endourology and laparoscopy, and was named the Director of Minimally Invasive Surgery. He

has long been recognized as one of the original national leaders in the field of robotic assisted pediatric laparoscopic surgery. In 2012, with the opportunity to return to his native New York, he accepted the position of Professor and Chief of the Division of Pediatric Urology at Columbia University Medical Center. During his tenure at Columbia, he was the Director of Robotic Surgery at the Morgan Stanley Children’s Hospital/New York Presbyterian Medical Center. After spending several years at Disney Children’s Hospital, part of Advent Health in Orlando, Dr. Casale decided to return to full-time academic medicine. Dr. Casale is widely known in pediatric urology for his pioneering work in expanding robotic surgery to the pediatric population. He will be bringing his robotic expertise to Nemours. Dr. Casale has published and lectured extensively in all aspects of pediatric urology, with emphasis on robotic surgery. He has more than 65 peer reviewed publications, 30 book chapters, 40 videos, 350 editorials, and has been invited as visiting professor to urology training programs across the United States and Canada.

After 13 years, our esteemed colleague and friend, Dr. Ahmad Bani Hani, Clinical Associate Professor and Director of Urology Residency at Nemours, moved to Austin, TX, to join the Texas Children’s Hospital-Austin, as Chief of Pediatric Urology, and Dr. Ahmad Professor of Urology Bani Hani at Baylor College of Medicine. While at Nemours, Dr. Bani Hani was instrumental in expanding the comprehensive urological care of patients with myelomeningocele and neurogenic bladder, developing protocols for the management of the adolescent varicocele, and participated closely in all aspects of complex urinary tract reconstruction. He supervised, mentored, and offered insightful feedback to the urology residents from Jefferson and other institutions rotating at Nemours. Nationally, he was the Chair of the Pediatric Health Section of the Public Education Council of the Urology Care Foundation. Our heartfelt gratitude to Ahmad for his dedication and efforts while at Nemours and Jefferson, and we wish him and his family success and happiness in Austin.

New Research Grant for Dr. Puneeta Ramachandra Congratulations to Dr. Puneeta Ramachandra, Clinical Assistant Professor of Urology, on her recent PKIDS grant. Funded by Patient-Centered Outcomes Research Institute (PCORI), PKIDS, the Pediatric KIDney Stone Care Improvement Network, is a national collaborative to improve the care of children with kidney stones. The goals of this study are to improve the ability of pediatric patients and their caregivers to select surgical treatment options for kidney stones and to enable urologists to use techniques that result in the best outcomes for these surgeries. The rapid increase in the incidence of kidney stones among youth has resulted in a large population of patients who require surgery to removes stones but for whom little evidence exists to guide clinical care. Proper selection of surgical treatment options, which is directed by patient-specific factors and individual treatment goals, is the greatest determinant of successful outcomes. Investigators seek to compare stone clearance, re-treatment, and unplanned healthcare encounters for ureteroscopy, shockwave lithotripsy, and percutaneous nephrolithotomy. 36

Year in Review

Pediatric urology faculty, advanced practice providers and urology residents at Nemours Children’s Health-Delaware in Wilmington, Jefferson Health’s pediatric partner. (Missing Dr. Pat Casale)

2023 William Ferris, MD, Pediatric Urology Visiting Professor, Dr. Stacy Tanaka On October 11 and 12, the Division of Pediatric Urology had the pleasure of hosting Dr. Stacy Tanaka, Chief of the Division of Pediatric Urology at Children’s of Alabama and Professor of Urology at The University of Alabama-Birmingham, as the 2023 Pediatric Urology Visiting Professor. Among her many academic responsibilities, Dr. Tanaka is the Editor of AUANews; she participates on the ABU Oral examination and written examination committees; she sits on the Spina Bifida Association Health Care Guideline Committee; she is the Co-Chair of USNWR Pediatric Urology working group; she is Assistant Editor Pediatric Section Journal of Urology, and is on the AAP Section of Urology Executive Committee. On October 11, she presented two lectures: “Urinary incontinence: (a mostly) evidencebased approach”, and “Urodynamics in pediatric myelomeningocele.” On October 12, she gave Urology Grand Rounds at Jefferson titled, “AUA publications: an insider perspective (What I’ve learned so far)” (see

page 28). This was an extraordinary account of a transition from pure clinical urology to participation in numerous committees and editorship of the AUANews. Her lectures were highly informative, enjoyable and well received. The urology residents from Jefferson and Cooper participated in case presentations and discussion. Dr. Tanaka was the 38th Pediatric Visiting Professor at Nemours Children’s HealthDelaware. The conference was established in 1991 by the former Chief of the Division, the late R. Bruce Filmer, MBBS, Associate Professor of Urology at Thomas Jefferson University, at the then Alfred I. DuPont Institute. Since then, some of the most prominent national and international pediatric urologists have visited our institution yearly in the early Fall, and initially, bi-annually. This event has been held yearly except for 9/2001, following the events of 9/11/2001. In 1992, the Delaware Academy of Medicine and the Nemours Foundation created the L. William Ferris Memorial Lecture in Pediatric

Urology, through a fund from the Ferris family honoring the memory of Dr. Ferris, the first urologist in Wilmington to dedicate a portion of his practice to pediatric urology. In the fall of 2021, Bill and Donna Hohn and their son, Matt, a former patient, voluntarily donated a generous gift to the Division of Urology to support the education of residents, students and medical personnel, and the conference is now named the William L. Ferris Memorial Lecture in Pediatric Urology Visiting Professorship Sponsored by the Hohn Family.

In 1992, the Delaware Academy of Medicine and the Nemours Foundation created the L. William Ferris Memorial Lecture in Pediatric Urology honoring the memory of Dr. Ferris, the first urologist in Wilmington to dedicate a portion of his practice to pediatric urology.

Dr. Stacy Tanaka, 2023 Pediatric Visiting Professor, with residents at Nemours in Delaware.

Jefferson Urology

News from Division of Pediatric Urology Pediatric Urology Academic Report 2023 MANUSCRIPTS Gruber, A, Saul, D, Gould, S, Hagerty, J, Figueroa, TE, Schwartz, B, Investigating the Rate of Screening for Müllerian Anomalies in Infants with Known Renal Anomalies. J Ped Adol Gyn, 2023. DOI: 10.1016/j.jpag.2023.01.084 Ambrose, N, Sadacharam, K, Burke, B, Figueroa E, Lang R, Kjelstrom S, Hagerty J, Spinal versus General Anesthesia: Comparing Outcomes in Pediatric Patients Undergoing Urologic Procedures, J Ped Urology, 2023. DOI: 10.1016/j. jpurol.2023.06.024 Gagliardi, F, Lauro, A, De Anna, L, Tripodi, D, Esposito, A, Forte, F, Pironi, D, Lori, E, Gentile, PA, Marino, IR, Figueroa, TE, and D’Andrea, V: The risk of malignant degeneration of Mullerian Derivatives in PMDS: A review of the literature. J. Clin. Med 2023, 12(9), 3115. DOI: 10.3390/jcm12093115 PRESENTATIONS Finkelstein J, McQuiston L, Ballesteros N, Figueroa, TE, et al: Variation and Opportunities to Improve Testicular Torsion Care: The National Surgical Quality Improvement Program Pediatric Testicular Torsion Collaborative, Societies for Pediatric Urology Fall Congress, Houston, TX, September 21-24, 2023 Figueroa, T E: “Overview of Uro-Renal Embryology and Developmental abnormalities”. Uro-Renal Course, second year curriculum, Cooper Medical School of Rowan University, Camden, NJ, January 2, 2023 Figueroa, T E: “Uro-Renal ALG Course: a case of ambiguous genitalia.” Uro-Renal Course, second year curriculum, Cooper Medical School of Rowan University, Camden, NJ, January 2-6, 2023 Figueroa, TE: Circumcision: “Contemporary views on an ancient operation.” Department of Pediatrics NCH-JeffersonChristiana Care Noon Resident Lecture Series. August 31, 2023, Wilmington, DE De Cotiis, K: Transitional Urology: Sexual Health Concerns (Mid-Atlantic session of the AUA – Williamsburg, VA 10/2023) De Cotiis, K: Pediatric Board Review Course (Nemours Children’s Sponsored – 9/2023) De Cotiis, K: Differences of Sexual Development (Jefferson Medical College – 9/2023) De Cotiis, K: Differences of Sexual Development for the Surgeon (Nemours General Surgery Grand Rounds 8/2023) De Cotiis, K: Management of Neurogenic Bladder (Physical Medicine and Rehab Residency at Jefferson Medical College 4/2023) De Cotiis, K: Genitourinary Anomalies (Genetics PhD Program at Jefferson Medical College 3/2023) De Cotiis, K: Management of Vesicoureteral Reflux (Cooper University Urology Grand Rounds 1/2023) Ramachandra, P: "Pediatric to Adult Urologic transitional care: what do general urologist need to know?" Mid-Atlantic AUA Meeting, Williamsburg, VA, 10/2023 38

Year in Review

Pediatric Sacral Neuromodulation Program at Nemours Delaware Urinary incontinence is a widely common condition in the pediatric population. The inability to attain socially expected urinary control in children can cause significant stress for the parents, the children, and the rest of the family. About 10% of children 5 years and older may still experience daytime urinary incontinence, often associated with urinary urgency and frequency, and constipation. Many of these children also experience enuresis, or nighttime wetting. Although urinary continence is eventually achieved in many children, some continue to struggle to control urinary function. The treatment of urinary incontinence is well documented, and many children respond to a variety of behavioral modification techniques as a first line therapy. Some children require a second line approach including pharmacotherapy to help control the urinary symptoms and restore age-appropriate urinary control. Failure to respond to optimal first- and second-line therapies may prompt the need for additional invasive imaging or investigation, and consideration for more invasive treatment, or third-line options. One of these third line options is sacral neuromodulation. Sacral neuromodulation was initially developed for the treatment of refractory urinary urgency and frequency, urinary incontinence, nonobstructive urinary retention, and fecal incontinence in adults. In 2016, as an attempt to offer third line therapy for children with refractory urinary incontinence, urgency, constipation and nonobstructive urinary retention, our pediatric urology team at Nemours Children’s Hospital Delaware (NCH-DE) developed the first program dedicated to offer the Medtronic InterStim sacral neuromodulation to children in the Delaware Valley. To date more than 50 patients have been treated at NCH-DE with more than 120 implantations. The primary indications for implantation of the device have been refractory idiopathic urinary urgency, urinary incontinence, constipation, and nonobstructive urinary retention. Since the Division of Pediatric Urology started to offer this device, they have extended the indications to highly selected patients with neurogenic bladder secondary to mitochondrial disease. Mitochondrial disease is a genetic condition which affects the function of the mitochondria, leading to a wide range of complex symptoms and presentations including neurological disorders, weakness, loss of muscle coordination activity, and as a consequence, many urological symptoms. Poor muscle function may lead to lower urinary tract symptoms or incomplete bladder emptying. Some patients with detrusor underactivity develop urinary frequency, overflow incontinence, decreased or interrupted urinary stream, hesitancy, and decreased sensation to void. In 2022, Nemours Children’s Health-Delaware reported their experience with the treatment of this condition using the implantable device (1). Patients in this study were found to have a spectrum of lower urinary tract dysfunction (LUTD) with elevated bladder capacity being common. No singular urodynamic feature prevailed although detrusor sphincter dyssynergia was found in 50%. Progression of symptoms over time was also common. Most patients (67%) did go on to surgical intervention including placement of suprapubic tubes and sacral neuromodulation. Sacral neuromodulation is one of the many options available at NCH-DE for treatment of lower urinary tract dysfunction. Careful evaluation and proper selection of patients are critical to attain a high degree of success in the treatment of patients with urinary symptoms. 1. Kucherov V, Truong H, Raab C, Hagerty JA. Urologic Presentations and Management Options in Pediatric Mitochondrial Disease. Urology. 2022 Jun;164:230-237.

Provider Spotlight: Traciann Carr, BSN By Lisette Hilton Traciann Carr, BSN, office nurse coordinator in the outpatient urology practice at Abington Memorial Hospital, said the supervisory role she holds today came just at the right time in her career. Traciann worked in outpatient urology at Jefferson soon after getting her RN license in 2011. After about 4.5 years and earning her Bachelor of Science in Nursing (BSN) degree, Traciann transitioned to inpatient care at Abington Memorial and worked as a bedside nurse for the next 5.5 years. Traciann Carr, BSN

She enjoyed her years as a bedside nurse, but missed urology and the bonds she would create with patients. Then, the pandemic hit, and it changed acute care nursing. Traciann said she was ready for a change.

“When I was given this opportunity to come back to the outpatient setting, I was eager to make the leap,” Traciann said. “It was exciting because it was a brand-new office, with fresh attendings starting off their practices. It was a big deal to be part of such a role and transition.”

She also enjoys her leadership responsibilities as the lead ambulatory nurse.

Traciann has helped to grow the new Jefferson urology location for the last year and a half, and while she said there have been growing pains, the job offers what satisfies her most about being a nurse.

One of Traciann’s themes as a nurse leader is to lead by example.

“I love the continuity of care. When you’re working in the outpatient setting there are certain patients that come back for routine care. You get to know them, and they become like extended family,” Traciann said.

Another is to always have an door open policy to staff, whether they have an issue in or outside of work.

The Jefferson urology practice in the Price Medical Building at Abington has given Traciann the opportunity to return to her roots in the specialty. “I have always enjoyed urology,” she said. “A lot of urology is working with the geriatric population and that is where my heart has always been.”

“I love teaching. When we have new staff members, I enjoy training, especially when it comes to all of the outpatient procedures,” Traci said.

“If I’m expecting it of you, I need to expect it of myself,” she said.

“The way you present yourself to the staff and patients is important because it’s a reflection of the urology practice,” Traciann said. “I want to see this position through and this office thrive.” Traciann’s focus outside of work is raising her young children. And in those rare moments when she has a little downtime, Traciann said she loves to read. “I enjoy reading mystery novels, and I’m a sucker for a good love story,” she said.

Oncology and neurogenic bladder patients are among the cases Traciann said she finds most interesting.

Jefferson Urology

Notable & Newsworthy Dr. Paul Chung World News Tonight Prostate Screening Public Service Announcement

Each year, September is recognized as Prostate Cancer Awareness Month. During September 2023, Dr. Paul Chung was featured on a series of public service announcements discussing PSA screening for

the detection of prostate cancer. The Jefferson spots were coordinated by our marketing partner, Mr. Nick Coffey, and ran during the ABC World News Tonight time slot.

Dr. Gomella Featured on the Dr. Brian McDonough Show and FOX-29 Interview Dr. Brian McDonough is a well-known medical reporter for both TV and radio. He now produces his own podcast, “The Brian McDonough Show.” The podcast started with a simple purpose: to explain, in an easy-to-understand format, information surrounding the coronavirus pandemic as the news developed. The emergence of The Dr. Brian McDonough Show was a logical progression, driven by the realization that as the pandemic transitioned into an endemic phase, the public sought both diversions and essential information. The show skillfully merges helpful health advice with “escapism,” addressing other topics, that according to Dr. McDonough, “are good for your overall health.” Dr. Leonard Gomella conducted an interview with Dr. McDonough (pictured top) discussing ways to detect prostate cancer early in order to treat it effectively. (Dr. McDonough’s shows are available on various platforms including Apple Podcasts and Spotify.) Additionally, Dr. Gomella was interviewed on FOX-29 in March 2023. Dr. Gomella discussed a widely publicized research report indicating that in the United Kingdom, there was no difference in prostate cancer mortality in a group of men who were observed or treated with surgery or radiation. An important aspect to this study is that all of the men studied had nonaggressive, localized prostate cancer. 40

Year in Review

Online Webinars and Educational Events Over the last year our Jefferson Urology faculty has been involved in several webinars and other online interactive educational programs.

A live Facebook event was held on September 20, 2023, which discussed prostate cancer.

Specifically discussing the diagnosis, management, basic research and the role of clinical trials in treating prostate cancer. Panelists included Dr. Leonard Gomella, Moriah Cunningham, our PhD student doing basic science research into the treatment of prostate cancer ,and SKCC Clinical research coordinator Joshua Blanding-Godbolt. The program is available online: www.facebook. com/SidneyKimmelCancerCenter/ videos/2220714098123911/

A virtual, live Q&A session with a multidisciplinary panel of Jefferson Health physicians specializing in Pelvic Medicine and Reconstructive Surgery was held in June. Dr. Whitney Smith, assistant professor of Urology

with additional fellowship training in female pelvic health and reconstructive surgery, participated in the program that addressed the diagnosis, management and treatment of pelvic floor disorders and incontinence.

That successful program in June was followed by an additional Webinar in November 2023. One in three women will experience a pelvic floor disorder (PFD) in her lifetime. PFDs occur when women have weakened pelvic muscles or tears in the connective tissue, which may cause bladder control problems, bowel control problems or surrounding pelvic organs to fall into the vagina causing pelvic organ prolapse. Jefferson Health’s Comprehensive Female Pelvic Medicine and Reconstructive Surgery multidisciplinary team specializes in the diagnosis, management, and

treatment of PFD’s. Speakers included urologist Dr. Whitney Smith and physical therapist Dr. Rachel Rosvold.

Rector Simulation Center Receives American College of Surgeons Reaccreditation

Simulation is a growing instructional modality in Health Care that offers opportunities for assessment across many domains. The American College of Surgeons created the Accredited Education Institutes (AEIs) to build a community of highquality simulation centers focused around improving surgical education and training. This past year, the Rector Clinical Skills and Simulation Center in the Hamilton building was awarded reaccreditation for five years as a Comprehensive Education Institute. The center provides simulation support for all health care learners across the University and the Jefferson Health enterprise. This includes clinical outpatient simulation offices and inpatient clinical simulation rooms, a virtual operating room, a virtual trauma or anesthesiology bay, virtual ICU’s or step-down units, and two multipurpose high sophisticated simulation rooms, one mainly for diagnostic simulation (Harvey Room) and the other for procedural (Sim-man and Noelle) for procedures such as ultrasound guided central line placement. A variety of surgical simulators include robotic, laparoscopic, GI endoscopic and urology stations for trans urethral and ureteroscopic procedures. See page 43 for urology simulation updates. The facility is directed by Drs. Kate and Dale Berg with Dr. Costas Lallas heading up Surgical Simulation in the Rector center.

On November 9, Drs. Paul Chung and Perry Weiner from our Jefferson Men’s Health program

participated in a web event that discussed erectile dysfunction and the implications for men’s health.

Jefferson Urology

Notable & Newsworthy Single Port Robotic Surgery Program

TJUH Upgrades Blue Light Cystoscopy Systems

Drs. J. Ryan Mark, Assistant Professor of Urology and Chief Resident Brian Calio were invited to the headquarters of Intuitive Surgical to evaluate updated technology and instrumentation for the Single Port (SP) daVinci robotics platform offered to select patients at Jefferson since 2022. The daVinci SP is a novel surgical robot allowing the surgeon to perform complex surgical procedures through a single 3 cm incision. There are 13 daVinci SP robots in our area and currently Drs. J Ryan Mark and Assistant Professor Mihir Shah are the highest volume SP urologic surgeons in the Mid-Atlantic region. SP urology procedures include Retzius-sparing prostatectomy, transvesical simple prostatectomy, transvesical radical prostatectomy, and completely extraperitoneal approaches to partial nephrectomy, nephroureterectomy, and upper tract reconstruction.

Sonia Hurtado, RN, Urology Nurse Specialist with Adam Beck, Storz representative, and PGY 3 Urology resident Mauro Dispagna reviewing the features of the new Storz Blue Light cystosopy system.

“Blue light cystoscopy” is a technique that combines the intravesical installation of an agent called CysviewTM with a special cystoscopic system to assist in the diagnosis of bladder cancer. When using the medication in combination with special cystoscope system bladder cancers that may not be visible under white light “fluoresce” under the wavelength of the blue light. Long before the approval of CysviewTM for “blue light cystoscopy” in 2010, Jefferson Urology was involved in the earliest clinical trials and has the largest experience

in the region. We are pleased that three new Storz blue light cystoscopy systems have been installed in the endourology suites of Thomas Jefferson University Hospital. According to Sonia Hurtado, RN Urology Nurse Specialist, “Our team has been using blue light cystoscopy for many years. These new cystoscopic towers provide amazing visualization thanks to the new high definition camera heads and monitors. The ability to adjust the floursecence will allow even greater cancer detection for the benefit of our patients.”

Dr. Gomella Gives 2023 Victor A. Politano, MD, Lecture at Duke During the Duke Urology 54th Annual Urologic Assembly, Dr. Gomella was invited as the 2023 Victor A. Politano Lecturer. Dr. Politano, considered to be one of the most influential

modern-day urologists, completed his residency at Duke with the family endowing the lectureship in his honor.

Drs. Brian Calio and Ryan Mark 42

Year in Review

Dr. Gomella with members of the Duke faculty during their annual urology assembly.

Rivas Family Upgrades Urology Simulators in the Rector Center Dr. David Rivas and his wife, Joyce, are passionate supporters of surgical simulation with a focus on urology. In 2020, they donated the TURP Mentor Surgical Simulation System that has allowed Jefferson urology residents to experience and become proficient at an array of transurethral surgeries before setting foot in the operating room. The Rivas family has continued their commitment by supporting the purchase of one of the latest simulation training devices, the URO Mentor system by SIMBIONIX. URO Mentor provides comprehensive virtual environments, as close to a real patient as possible, using actual endoscopes. The system features an authentic rigid cystoscope, a rigid ureteroscope, and a flexible cystoscope/ ureteroscope with working channels for various tools. David Rivas, MD, is a 1984 alumnus of Sidney Kimmel Medical College and completed his Urology residency (1987-91) and fellowship training in Neurourology and Incontinence (1992-94) at Jefferson. He continued as an Assistant Professor of Urology at Jefferson from 1994 to 2000, when he also served as the Director of the Division of Neuro-Urology. David then pursued clinical research and development in the pharmaceutical industry. Joyce Rivas is Advisory Chairperson at Doylestown Hospital’s Animal Assisted Therapy Program. Drs. Costas Lallas, David Rivas, and Kenny Brownstein visiting the Rector center with the new URO Mentor platform.

The Rector Simulation Center recently was re-certified by the American College of Surgeons (see page 41).

Jefferson Health Urology Council At the request of Dr. Baligh R. Yehia, President of Jefferson Health and Dr. Edmund Pribitkin, Chief Physician Executive Jefferson Health and President, Jefferson Medical Group, we have established a Jefferson Health Urology Council. The role of the council is to provide feedback to Jefferson Health leadership on important issues impacting our specialty practices and to ensure effective recruiting, coordination of care while maintaining quality and safety standards across the enterprise. There will be representation from each of our Jefferson Medical Group practice locations. Council members and their designated sites of service include: Dr. Leonard Gomella: Enterprise Urology Chair Dr. Patrick Shenot: Co-Chair, Thomas Jefferson Univerity Hospital Dr. Jeannne Llenado: Methodist/Navy Yard Dr. Perry Weiner: South Jersey/Jefferson East Dr. Ed Trabulsi: Einstein Philadelphia Dr. Marc Lavine: Jefferson North East Dr. David Altman: Plymouth Meeting/Einstein Montgomery/Lansdale Dr. Joseph Izes: Abington/Asplundh

Jefferson Urology

Notable & Newsworthy Department of Urology Moves up in Best Hospitals Rankings For their 2023-2024 surveys, U.S. News evaluated 1,472 hospitals and ranked the top 50 that see a significant number of challenging urology patients and treat conditions such as those affecting the urinary tract,

bladder, and prostate. We are pleased that the Thomas Jefferson University Hospital Department of Urology moved up to #30 and is rated among the 50 best programs in the United States.

Jefferson Launches Prostate Cancer Focal Therapy Program

Department of Urology residents and faculty participated in an on site demonstration of the High Intensity Focal Ultrasound (HIFU) unit from FocalOne.

Focal therapy is a growing treatment option for some men with early prostate cancer. The goal is to target and destroy the cancer while minimizing the impact on the rest of the prostate and surrounding tissues. It is best used to treat less aggressive prostate cancers that can be seen on imaging modalities such as MRI or ultrasound. Some of the more common focal therapy methods used today include cryotherapy, HIFU (High-Intensity Focused Ultrasound) and 44

Year in Review

irreversible electroporation, called IRE or NanoKnifeTM. Drs. Patrick Gomella and Adam Metwalli are co-directors of the new program, and both have extensive experience from the National Cancer Institute in targeting prostate cancer using MRI. Patients will be seen our Sidney Kimmel Cancer Center Multidisciplinary Clinic for full evaluation to determine if they are the proper candidates for focal therapy treatment. The program will start in early 2024.

Jefferson at the Navy Yard Celebrates Milestone November 2023 marked the fiveyear anniversary of our Navy Yard facility expansion with the addition of specialties and departments in 2018. Starting out on just one floor, the multispecialty practice has grown to a spectacular four floor ambulatory facility. Urology takes credit for opening the first practice at the Navy Yard in 2010. According to Dr. Jeanne Llenado, Assistant Professor of Urology and long-time Navy Yard provider, “It is amazing to have experienced such growth at the Navy Yard over the last 13 years. It has become the destination of choice for many of our Jefferson patients due to the expanded services, convenient location, and easy parking.”

Jefferson providers and staff gathered for a photo celebrating the five-year anniversary expansion of our Navy Yard facility. Dr. Irv Hirsch, Professor of Urology (first row left), has been a long-standing Navy Yard physician specializing in Men's Health.

Dr. Weiner Performs First LEP at Jefferson Health-East Region Laser enucleation of the prostate (LEP) is a procedure used to treat symptomatic benign enlargement of the prostate. The procedure is performed transurethrally with the laser used to cut out the enlarged portion of the prostate. A device called a morcellator is used to flush out the fragments of the prostate from the bladder. No incisions are necessary, and the procedure is usually best reserved for prostates that are greater than 80-100 cc. Several types of lasers can be used for the enucleation procedure, with Dr. Weiner using a diode laser to perform the procedure. When using a diode laser, the procedure is often referred to as a DiLEP.

Department of Urology 2023 Town Hall On August 10, 2023 Dr. Leonard Gomella, Jefferson Urology Chair, conducted a Town Hall presentation that reviewed the patient care, teaching and research activities of the SKMC Department of Urology. The event was recorded and was reviewed at different dates at all of our regional practice locations. The video link to the program is available at: www.sjefferson.hosted.panopto.com/Panopto/Pages/Viewer. aspx?id=96f8231e-087d-49e4-b206-b0600139a6e2

Dr. Weiner is the Director of Jefferson’s Mens health Program and clinical director for Jefferson Urology in the East Region. Previously Dr. Weiner only offered the diode LEP procedure at Jefferson Methodist Division and has performed more than 375 procedures. Jefferson Urology

Community Outreach & Engagement Prostate Cancer Awareness and Screening Programs By Anthony V. Coppola The Department of Urology at Jefferson Health has for decades been a fixture when it comes to prostate cancer awareness and screening

efforts. Now, the department is taking full advantage of the new SKCC resources it has available to prioritize a more communitybased approach to care for the Jefferson Health catchment area.

“We’ve been involved with prostate cancer screening efforts for a long time,” stressed Department of Urology Chair Leonard Gomella, MD, FACS. “From 1990 until 2018, men usually had to come to Center City for the screening events, and now our team is out on the road more in the communities doing the screenings. The focus has really become community awareness based.” A major component of the Department of Urology’s recent outreach success is the Sidney Kimmel Cancer Center – Jefferson Health Mobile Screening Unit, is made possible through a partnership with Dietz & Watson. The Department of Urology has teamed with SKCC’s Community Outreach & Engagement office since November 2022 through November 2023 and has provided 24 prostate cancer awareness and screening events throughout the Philadelphia region. Modern screening involves a questionnaire and a no cost to the patient prostate-specific antigen (PSA) blood test. Urology’s NPs, Fatuma Doka and Suzanne Barron, along with Urology protocol coordinators Alex Kolesnikov and Olivia Dahlgren are frequent participants in our prostate cancer screening events.

The SKCC Screening van is sponsored by Dietz and Watson. Here, our Jefferson team is joined by members of the Dietz & Watson family executive leadership, Chris Eni (COO), and Cindy Eni Yingling (CFO).

The Philadelphia Community College screening event.

Year in Review

According to SKCC Mobile Screening Unit Program Manager Kristine Pham, so far 431 men were screened with 64 referred

Alex Kolesnikov and Olivia Dahlgren, Urology protocol coordinators, with our Johnson and Johnson community prostate cancer screening supporters Maria Reilly and Casey Pappis. This prostate cancer awareness and screening event was held at the Bethany Baptist Church in West Philadelphia this past March.

For more information on our community outreach, for follow-up appointments. Of the 322 men who submitted race/ ethnicity data, 43 percent were Black. It’s an important statistic, as an obvious priority for the Department of Urology when it comes to community awareness is targeting more at-risk populations.

engagement, and screening efforts visit www.jeffersonhealth.org/clinical-specialties/ cancer/community-outreach-engagement.

“Prostate cancer is a particular burden in the African American community,” Dr. Gomella said. “They have higher rates and are more likely to die from prostate cancer.” In September 2023, Moriah Cunningham, a PhD student in the urology research lab, organized a community outreach event at New Covenant Church of Philadelphia. The event was geared toward Black men at the North Philadelphia church, according to Cunningham, and offered them a chance to learn about prostate cancer research in the SKCC catchment area, in addition to screening opportunities (see page 49). “Community engagement is crucial because we don’t know the hardships the community faces,” Cunningham said. “It’s important to keep in perspective what the community we serve needs and wants as far as clinical care and research. Without community, we wouldn’t have jobs. Our purpose is to increase the wellness of the community around us.” A tremendous amount of credit for the Department of Urology’s positive impact goes to the Prostate Cancer Education Council (PCEC) and companies like Johnson & Johnson Innovative Medicine who support our local efforts, according to Dr. Gomella (see photos for Johnson and Johnson community supporters). “The PCEC started Prostate Cancer Awareness Week way back in the early 1990’s, and we’ve been partners ever since,” Dr. Gomella said. And the relationship has grown tremendously since then. Among the greatest benefits for the Department of Urology is that “Thanks to their philanthropic initiatives, PCEC runs the PSA screening blood test for us at very low cost, in the $5 range,” Dr. Gomella said.

Our Department of Urology team featuring Alex, Doka, and Olivia on the road with the SKCC screening van at a community prostate cancer screening event.

“We could not do this if it wasn’t for the PCEC,” Dr. Gomella added. “We do some work here, but the process is seamless because PCEC has the IRB compliant questionnaires we use, they do the blood processing for us, and help with promotion and disease awareness.” PCEC, in turn, lauded Jefferson Health and the SKCC as valued allies. “Jefferson’s at the top,” PCEC President Wendy Poage said. “They’re a great screening partner, and with the mobile van, their reach to at-risk communities has skyrocketed. I’d say they’re tops in the nation and have been for the last several years.” Poage called PCEC’s relationship with Dr. Gomella and the Department of Urology “absolutely wonderful.” “It’s been a long partnership with Dr. Gomella who has been a core member of our PCEC board. These screening efforts have produced amazing data and numerous research publications,” Poage said. “The number of screenings Jefferson does is blowing everyone out of the water, and their work in at-risk communities is a model for what we should be doing to decrease the burden of prostate cancer.” The SKCC Screening Van offers additional community screening programs for other conditions such as breast and head and neck cancers.

Drs. Amy Leader, SKCC Associate Director for Community Outreach, and Leonard Gomella along with Moriah Cunningham and her father, Michael, participated in a prostate cancer awareness event along with ZERO Prostate Cancer, an organization dedicated to prostate cancer initiatives. The July event was held at the Frazier Family Coalition Center in North Philadelphia, a joint community center supported by Jefferson Health and Temple Health. Jefferson Urology

Community Outreach & Engagement For information on the Prostate Conditions Education Council (PCEC) can be found at www.prostateconditions.org/

Fred Beans Subaru in Doylestown hosted a screening event for their employees. The SKCC team is holding custom “Fred Beans Cookies” made for the event.

The PCEC is an SKCC partner in our prostate cancer screening and awareness events. A national organization committed to men's health, the Prostate Conditions Education Council (PCEC) is a nation‘s leading resource for information on prostate health and is dedicated to saving and improving the lives of men and their loved ones from prostate disease. Founded in 1989, PCEC is a 50l(c)(3) nonprofit, comprised of a consortium of leading physicians, health educators, scientists and prostate cancer advocates. PCEC aims to conduct nation-wide men's health assessments and perform research that will aid in the detection and treatment of prostate and men's health conditions.

Prostate cancer screening event at the Enon Tabernacle Church. From left to right: Sheila Polite, Katie Bradley, Suzanne Barron, Chris Horn, Amy Leader, Latonia Jackson, and Alex Kolesnikov. Chris Horn and Latonia Jackson are supporters from Johnson and Johnson.

As the founder and coordinator of the national Prostate Cancer Awareness Month in September, PCEC has screened more than five million men across the country for the disease and has become one of the largest and most successful prostate health assessment projects in the world.

A prostate cancer screening and awareness program at the Mexican Consulate in Philadelphia. 48

Year in Review

Prostate Cancer Awareness and Screening Programs

Latese Evans and Moriah Cunningham, PhD students in our Department of Urology Schiewer Research Lab, are proactive in community outreach to talk about prostate cancer with a focus on the African American community. They have participated in numerous church programs and with Jefferson Health sponsored Frazier Center on West Lehigh Ave in Philadelphia.

Shown here are SKCC members Dr. James Posey, Medical Oncology, Josh Blanding Godbolt, Clinical Research Coordinator, with Latese Evans and Moriah Cunningham during a prostate cancer information and screening program at the New Covenant Church of Philadelphia on Germantown Avenue on September 16, 2023.

2023 BCAN Walk to Support Bladder Cancer Awareness Bladder Cancer Advocacy Network (BCAN) Walk 2023 to end bladder cancer was held on April 29, 2023, in Philadelphia. Sidney Kimmel Cancer Center participated in the walk to raise awareness for bladder cancer. From left to right, first row: Jasmine Sweeting, Patrick Mille’s children GU Multidisciplinary Clinic Coordinator and Crystal Sypherd. Second row: Drs. Patrick Mille and Kevin Zarrabi from SKCC Department of Medical Oncology, and Dr. Mihir Shah, Department of Urology.

The Bladder Cancer Advocacy Network (BCAN) is a community of patients, caregivers, survivors, advocates, medical and research professionals united in support of people impacted by bladder cancer. Bladder cancer is a disease that impacts more than 790,000 patients in the United States including both men and women.

Jefferson Urology

Graduations and Awards Chief Residents and Fellows Graduation ANTHONY TOKARSKI, MD

Chief Resident

Anthony Tokarski was born and raised in Bucks County, PA, where he lived with his parents Tony and Diane, younger brother Jon, and grandmother Reiko. He attended Holy Ghost Prep, where he ran varsity track for four years. He went on to attend Penn State University, graduating with a B.S. in Biology and completing his honors thesis in Biochemistry and Molecular Biology. After college, he began working as a clinical research fellow at the Rothman Institute, focusing mainly on outcomes research in joint reconstruction and periprosthetic joint infections. Anthony then went on to attend Sidney Kimmel Medical College. His interest in urology was sparked after his third-year rotation (which he

ANDREW SALIB, MD

Chief Resident

Andrew Salib, MD is the oldest of three siblings and was born in Alexandria, Egypt. At the age of 14, he immigrated with his family to East Brunswick, NJ, where he finished his high school education. After a short assimilation period, Andrew was able to excel academically graduating at the top of his class and received a full academic scholarship to Rutgers University. There, he participated in numerous pre-med clubs and was a certified EMT for the South River rescue squad. He was also involved in basic science research at Robert Wood Medical School studying spinal cord injury in a mouse model. Andrew graduated summa cum laude with a BA in Biology and received an academic achievement award for maintaining a perfect grade point average throughout college. He then attended Robert Wood Johnson Medical School, where he received a merit-based scholarship. During his medical studies, Andrew became interested in the surgical specialties because of their ability to diagnose and physically fix conditions. Through different shadowing experiences and research opportunities,

scheduled on the advice of a former Jefferson resident), and he was fortunate enough to stay at Jefferson for his six years of urologic training. Outside of residency, Anthony is an ardent supporter of Philadelphia sports, enjoys nurturing his newly found hobby of photo/video editing, and spending time with his three sons. Upon graduating, Anthony will be completing a one-year robotic and endourologic surgery fellowship at the University of Pennsylvania. Dr. Tokarski: “I am forever grateful and honored to have been afforded the opportunity to train at Jefferson Urology. To the Jefferson faculty, I am truly humbled by the trust you put in me to take care of your patients, and for the countless hours you invested into training me to be the surgeon I’ve become. To all my co-residents, past and present, and in particular Eddie and Salib, you are what makes Jefferson such a special place to work. I’m not only proud to have trained with all of you, but consider you all my life-long friends. I would like to thank my parents, who provided me with the support and motivation I needed to be able to achieve my goals. I would not be standing here today without you. Finally, to my three sons, Nathan, Harry, and Charlie: you are what makes all the long hours worth it. I love you more than I could ever fully put into words, and I’m so proud to be your dad.” Andrew chose the field of urology due to its wide spectrum of pathologies and surgical interventions. When he is not working, Andrew enjoys spending time with his wife Maryann and daughter Abigail. They enjoy travelling, going to the shore, and exploring the Philadelphia restaurant scene. Despite living in Philadelphia for the past six years, Andrew is still an avid New York sports fan, especially of the NY Giants. Following graduation, Andrew will join Urologic Health Center of New Jersey in Toms River, NJ. Dr. Salib: “Jefferson Urology has a strong history and tradition, and I am fortunate to have trained here. I would like to thank Dr. Gomella and Dr. Shenot for giving me this opportunity. The variety of urological subspecialties and surgical volume taught me how to manage complex patients and gave me the confidence to enter practice next year. To my co-chiefs, Eddie and Anthony, I enjoyed operating with you and learning from you over the past six years. I couldn’t have survived this journey without you two. To my co-residents, the comradery we have is the strength of our program. Spending time with you was the best part of my day and is what I will miss the most. I would like to thank my parents Samir and Evett who made countless sacrifices for me to be here. To my brothers, Richard and Robert, thank you for your constant help and support. Most of all, I would like to thank my wife and best friend, Maryann, who has supported me and our family. Maryann, you are my better half, and I am very lucky to have you. I can’t wait for our next adventure together!”

Jefferson Urology Research Fellow RISHABH “RISHI” SIMHAL, MD

Dr. Rishabh “Rishi” Simhal joined us as a research fellow for one year after completing medical school at the Georgetown University School of Medicine in Washington, DC. He successfully matched and started his Urology Internship at Oschner Health in New Orleans.

Year in Review

EDWARD KLONIECKE, MD, MHA

Chief Resident

Edward Kloniecke, MD, MHA, was born and raised near Scranton, PA. He attended Scranton Preparatory School, where he was involved in theater as stage manager. He majored in Biology and Philosophy at the University of Scranton. After being offered a position in the biology lab, he decided to stay at “The U” to teach physiology lab courses for undergraduates and pursue a Master’s degree in Health Administration. While at the University of Scranton, Eddie was President of the Men’s Crew Team, and involved in international service work in Jamaica and Haiti. After his MHA, he moved to Philadelphia to attend Sidney Kimmel Medical College. Eddie knew from a young age he wanted to pursue a career in medicine, although his initial interest was in orthopedics. Ultimately, it was his third-year rotation in urology that cemented his career choice. He owes a debt of gratitude to previous Jefferson urology residents for igniting

and fostering his interest in the field. When not working, Eddie enjoys exploring the Philadelphia food scene with his wife Kathleen, supporting Philly sports, as well as skiing and traveling. Next year, he will return to northeastern Pennsylvania, where he will work at Geisinger. Dr. Kloniecke: “It’s hard to believe that 10 years in Philadelphia and at Jefferson have come and gone. I feel immensely proud and lucky to have trained here, at a place with such an extensive history in medicine and urology specifically. I cannot thank Drs. Shenot and Gomella enough for affording me the opportunity to do my residency here at Jeff. To the attendings, who have allowed me the privilege to care for their patients over the past six years, I’m honored to have worked with you all. To the residents, your friendship is what I will miss the most going forward. It’s easy to go through the trenches when you have amazing people with you. Thank you for the support throughout this past chief year. You made my job easy. To Anton and Salib, you are the brothers I never had. Thanks for always being there when I needed to decompress. I couldn’t have asked for a better class. To my parents, Ed and Kim, there are no words to adequately show how grateful I am for everything you’ve done for me. Without your love and support, there is no way I could have made it to this day. To Kathleen, my incredible wife, the best part of my day, thank you for standing with me and supporting this dream of mine over the past 10 years. You keep me grounded. You’re amazing, and I cannot wait for the next chapter of our lives together.”

DANIEL P. SIMON, MD

Endourology Society Fellow

Daniel Simon, MD, was born in Illinois and spent his childhood moving throughout the Midwest, ultimately settling in Kansas City. He attended Blue Valley West High School in Overland Park, KS, where he excelled academically and graduated in the top ten of his class of more than 400 students. Outside of the classroom, he served as chief editor of the high school newspaper and was a member of the varsity football team, which won the Kansas state championship in 2008. After high school, Daniel attended the University of Kansas on a full academic scholarship where he graduated with highest distinction, earning a Bachelor of Science degree in microbiology. He was actively involved on campus as a member of the University of Kansas Honor Society and served as vice president of the Delta Upsilon fraternity. During his time as an undergraduate, Daniel conducted basic science research in a lab studying Chlamydia trachomatis, which led to his selection as a K-INBRE research scholar and completion of the American Society for Microbiology (ASM) summer research fellowship.

Daniel attended medical school at the University of Kansas School of Medicine where he was inducted into the Alpha Omega Alpha (AOA) Honor Society. It was during this time that he developed an interest in the field of urology. This led to his involvement in clinical research on the shared decision-making model in the treatment of prostate cancer. He went on to complete his urology residency training at Rush University Medical Center in Chicago, Illinois. His involvement in clinical research during residency led to several awards, including the Rush Department of Urology Award for Research Excellence, and multiple publications, including a study on the treatment of chronic scrotal content pain published in the Journal of Urology. While in residency, he also served as vice chair for the Rush Resident Wellness Committee and gained clinical experience abroad while participating in a multidisciplinary surgical mission trip to Azua, Dominican Republic. Driven by a desire to care for complex patients and improve surgical recovery, Daniel chose to pursue a one-year fellowship in advanced laparoscopic and robotic surgery at Thomas Jefferson University. Upon completion of his fellowship, Daniel has accepted a position with Intermountain Healthcare and will be moving with his wife, Lauren, to Salt Lake City, Utah. Daniel met Lauren in medical school while she was completing her nursing degree at the University of Kansas School of Nursing. They were married in Park City in 2021, and Lauren transitioned into a career in medical devices. Outside of work, the couple enjoy travelling the world, hiking, and the Great Outdoors. As avid skiers, they are looking forward to their transition to the Wasatch Mountains.

Our thanks to Boston Scientific, who provides partial support for our Endourology Fellowship. Jefferson Urology

Graduations and Awards

Urology Awards 2022-2023 Academic Year

Max Koppel, MD, MPH Resident Achievement Award Zachary Prebay, MD – 2022 In Service Exam Drs. Pat Shenot, Zack Prebay and Max Koppel. Dr. Prebay has won the award two years in a row!

Dolores Shupp Byrne, PhD Senior Urology Awards

Caroline Purcell, MD SKMC Class of 2023 Adam C. Schneider, MD SKMC Class of 2023 Dr. Adam Schneider is currently an intern in the Department of Urology, shown alongside Dr. Dolores Byrne, Assistant Professor of Urology and the namesake of the senior urology award (Dr. Caroline Purcell was not available for the photo session.)

Jefferson Urology Scholars Graduation

Jefferson Urology Research Scholar 2022-2023 Kerith Wang, BA Kerith Wang, SKMC Class of 2024 receiving her commemorative plaque from, Dr. Costas Lallas. Dr. Lallas supervises the Jefferson Urology Research Scholars during their yearlong research experience, which is typically between 3rd and 4th year of medical School.

4 College of Life Sciences Graduation

Latese Evans, MS Latese Evans successfully defended her thesis and received her MS degree with her mentor Dr. Matt Schiewer, Assistant Professor of Urology and Vice Chair for Basic Science Research. Latese is continuing as a PhD student in Jefferson’s Genetics, Genomics, and Cancer Biology Program. Her research involves determining the basis of the sex disparity in bladder cancer and further defining the mechanism of drugs known as PARP inhibitors in prostate cancer.

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Year in Review

2023 Urology Graduation Celebration

Jefferson Urology

2023 Urology Graduation Celebration

Year in Review

Jefferson Urology

2023 Urology Graduation Celebration

Year in Review

Jefferson Urology

Residents and Fellows 2023-2024 CHIEF RESIDENTS (PGY 5) Brian Calio, MD Medical School: Sidney Kimmel Medical College Undergraduate: University of Delaware Interests: Eagles football, movies, Fantasy sports, golf

Halle Foss, MD Medical School: Medical College of Wisconsin Undergraduate: St. Olaf College Interests: Tennis, coffee, card/board games, exploring new bars and restaurants

Radhika Ragam, MD Medical School: Rutgers New Jersey Medical School Undergraduate: The College of New Jersey Interests: Golf, snowboarding, movies, beer gardens, biking on the Schuylkill River Trail

Courtney Capella, MD Medical School: Sidney Kimmel Medical College Undergraduate: Dickinson College Interests: Plants, National Parks, and Peloton

Maria D'Amico, MD Medical School: Boston University School of Medicine Undergraduate: Columbia University Interests: Yoga, Peloton, traveling, the beach

Joon Yau (JY) Leong, MD Medical School: Sidney Kimmel Medical College Undergraduate: International Medical University Kuala Lumpur, Malaysia Interests: Hieroglyphics, Oreos, being "niceee"

Mauro Dispagna, MD Medical School: SUNY Upstate Medical University's College of Medicine, Syracuse Undergraduate: University of Central Florida Interests: Soccer, Formula-1 racing, traveling, wine

Zachary Prebay, MD Medical School: Medical College of Wisconsin in Milwaukee Undergraduate: University of Michigan Interests: Michigan football, reading, coffee, running

Afzal Shakir, MD Medical School: University of Oklahoma College of Medicine Undergraduate: University of Oklahoma Interest: Trivia night, table tennis, bass guitar, flight simulators, 3D printing, movie character impersonations

Matthew Buck, MD Medical School: Frank H. Netter MD School of Medicine at Quinnipiac University Undergraduate: University of Connecticut Interest: U Conn basketball, hiking, coffee, urological oncology, observational research

David Fu, MD Medical School: University of Nebraska Medical Center Undergraduate: Boston College Interest: golf, basketball, cooking

Carlos Perez, MD., PhD Medical School: Minnesota Undergraduate: University of Puerto Rico at Cayey Interest: Long-distance running, anything related to reggaeton and Latin trap (merengue, salsa, bachata), cooking Puerto Rican food and trying to blend with midwest cuisine, a good beach day with friends

Daniel Inouyne, MD Medical School: University of Southern California Undergraduate: University of California Santa Barbara Interest: Cooking, craft, cocktails, volleyball, rock climbing

Michael Panagos, MD Medical School: University of Maryland School of Medicine Undergraduate: University of Michigan College of Engineering Interest: Michigan hootball, history, my two cats

Adam Schneider, MD Medical School: Sidney Kimmel Medical College Undergraduate: Loyola University Maryland Interests: Traveling, baking, volleyball, foodie

PGY 4

PGY 3

PGY 2

PGY 1 (INTERNS)

Year in Review

DR. DANNY INOUYNE

Welcome New Urology Intern Class

Our new urology interns Drs. Michael Panagos, Danny Inouyne, and Adam Schneider.

Welcome Rajiv Raghavan, MD 2023-24 Endourology Fellow Dr. Raghavan was born in upstate New York and attended Dartmouth College, where he completed dual Bachelor of Arts and Engineering degrees in biomedical engineering and competed in cross country and track and field. He stayed at Dartmouth for medical school at the Geisel School of Medicine and graduated in 2018 with honors. Next, he moved to Philadelphia where he completed urology residency at Temple. He lives in Cheltenham with his wife, Amy (an ER physician), their infant daughter Mira, and their dogs Taika and Brinkley (a Vizsla and a Brittany, respectively). He continues to run daily, compete sporadically, and he maintains a productive vegetable garden and small fruit tree orchard in his time outside of the hospital. Our Fellowship in Endourology was established in 1996. Through 2023, 22 fellows have completed the training program. This past year, our program was reclassified as a Fellowship in Endourology and Minimally Invasive Urologic Oncology. This one-year fellowship is under the direction of Drs. Costas Lallas and Scott Hubosky.

For the new academic year the Department is pleased to welcome our new intern class. Dr. Daniel “Danny” Inouyne joins us from California having completed his undergraduate degree at UC Santa Barbara and medical school at University of Southern California, Los Angeles. Dr. Michael Panagos was an undergraduate at the University of Michigan before graduating from the University of Maryland School of Medicine. Dr. Adam Schneider is a graduate of Sidney Kimmel Medical College, where he received the Dolores Shupp Byrne Urology Award (see page 52). His undergraduate degree is from Loyola University in Baltimore, Maryland.

I have had a wonderful experience at Jefferson so far. Everyone has been so friendly and welcoming, and I am excited to spend the next 5 years with the program!

I would describe my initial time at Jefferson as one of rapid growth and education. I have grown into the responsibility expected of me, and I am already more confident at three months than I ever would have thought possible thanks to the strength of the training program here. Dr. Michael Panagos

I am most thankful I have had the opportunity to train at Jefferson as a medical student and now as a resident. The people and relationships I've fostered here have made me better not only professionally, but even more so personally. Dr. Adam Schneider

2024 Chiefs Obtain Fellowship Positions Please join us as we congratulate our 2024 graduating Chief Residents on their fellowship appointments.

Dr. Brian Calio will be joining the Department of Urology, Duke University Medical Center as a Fellow in Robotic and MIS Surgery.

Dr. Radhika Ragam will be joining USC Institute of Urology at the Keck School of Medicine of the University of Southern California in Los Angeles for a Robotic Urologic Oncology & Minimally Invasive Surgery Fellowship.

Dr. Halle Foss has been accepted as a fellow Endourology and Minimally Invasive Urologic Surgery Fellowship at the Mayo Clinic in Rochester, Minnesota.

Jefferson Urology

Residents and Fellows 2023-2024 Residents Train in Mobile Prosthesis Lab Our Jefferson urology residents and others from area training programs participated in a Prosthesis Anatomy Lab, a mobile anatomy van, hosted by Boston Scientific on July 18, 2023. They learned about innovation in the field of urologic prosthetics and received handson experience implanting artificial urinary sphincters, slings, and penile implants. We express our thanks to Boston Scientific for providing this unique training program for our residents and Dr. Paul Chung for arranging and supervising the event.

1 Residents Drs. Zachary Prebay and David Fu participating in the prosthesis training lab supervised by Dr. Paul Chung. 2 PGY 4 residents Drs. Maria D’Amico and Courtney Capella training at the Boston Scientific mobile training lab. 3 Drs. Afzal Shakir and Mauro Dispagna, third year residents, looking confident, having completed placement of a penile prosthesis in an anatomic model in the mobile lab.

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Dr. Paul Chung supervised the residents in the Boston Scientific mobile training lab here in Phildelphia.

Residents Meeting Presentations Residents at all years of training have the opportunity to present at many of our national meetings. Over the last year, residents had presentations at or participated in the following meetings: SWIU: Society of Women in Urology SUFU: The Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction AUA: American Urologic Association MA-AUA: Mid-Atlantic AUA SMSNA: SNMA Sexual Medicine Society of North America A complete listing of meeting presentations including resident participation can be found on page 77. Drs. Maria D’Amico and Courtney Capella at the 2023 SUFU (The Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction) winter meeting in Nashville. The poster discussed the utilization of same day sacrocolpopexy during the Covid-19 pandemic. Jefferson Urology

Student News Jefferson Urology Society Workshop

SKMC students participating in the Jefferson Urology Society vasectomy Workshop.

The Jefferson Urology Society sponsored a hands-on workshop for those interested in learning the principles of vasectomy this past fall using suturing model kits. The Jefferson Urology Society is a student-run organization that provides medical students with the opportunity to learn more about the exciting and dynamic field of Urology. The goal of the society is to promote interaction among students, residents and faculty via informational sessions, research, shadowing

opportunities, and charitable events. The organization also works to provide interested students with faculty mentors who serve as role models and advisors for students, who are interested in pursuing a career in Urology. Historically, SKMC boasts among the highest numbers of students, who match in Urology in the United States. According to Dr. Costas Lallas, Faculty Advisor, “The Jefferson Urology Society is an effective way to introduce students

to our Urology specialty early in their medical school careers. It also engages students at all levels with faculty mentors, who can guide students in research, rotation electives and ultimately residency program selection.” The Jefferson Urology Society hosts a variety of other programs throughout the year such as introduction to robotic surgery and pre- and post-Urology match discussions. Any questions or comments can be directed to urology. society@jefferson.edu.

National SKMC Student Urology Presentations Multiple submissions by our 2022-2023 Jefferson Urology Research Scholar, Kerith Wang (SKMC 2024), were presented at the 2023 Society of Women in Urology meeting in Scottsdale, the AUA in Chicago and the Mid-Atlantic AUA meeting in Williamsburg among others. Our 2023-24 Scholars Brian Im and Aaron Hockberg (SKMC 2025) and Sohan Shah (SKMC 2026) had abstracts at the SMSNA (Sexual Medicine Society of North America) in November 2023. Dr. Paul Chung did an amazing job mentoring a variety of residents and students with Jefferson collectively presenting 6 podium sessions and two moderated posters. Details on these and all of our many other student and resident presentations at these and other national meetings along with their coauthors can be found on page 77.

Jefferson Urology Research Scholar Aaron Hochberg (SKMC 2025) presenting at the Sexual Medicine Society of North America in San Diego, California November, 2023. 62

Year in Review

Student Designed Urology Externship Featured in AUA News

Our Sidney Kimmel Medical College students Sohan Shah (SKMC 2026), Christina Grindley (SKMC 2026), Emily Yanoshak (SKMC 2025) and Yash Shah (SKMC 2025) published an article in AUA News in June 2023 describing a unique program for students to learn about urology. The following are excerpts from that article. Deciding during clinical rotations that you are attracted to the field makes it difficult to build a competitive resume before applying to the match. The average matched urology applicant in 2021 had 4 published articles and 9 other research items. For many students, their only option is to take a year off to conduct research to increase their likelihood of matching, further delaying the start of their lengthy residency training and subsequent career. The Jefferson Urology Society (JUS), has attempted to address these issues by providing opportunities for exposure to the field during the preclinical years. In 2020, we initiated a 2-week Winter Externship for first- and second-year medical students interested in urology. The Winter Externship is a 2-week rotation occurring when most third-year clerkship students are on winter break. This allows first- and second-year students to interact directly with residents and attendings and gain a realistic understanding of the field. This past winter, 5 students at SKMC participated. During their externship, students were able to scrub into a range of cases from robotic-assisted prostatectomies to percutaneous nephrolithotomies and penile prosthesis implantations. On days when students were not assisting in the operating room, they had the opportunity to shadow in the clinic. With access to attendings in reconstructive surgery, neuro-urology, and urologic oncology, students were able to observe many subspecialties within the field, helping to dispel the misconception that urology is a narrow field. The externship also helped students develop relationships with attendings and residents, resulting in several ongoing research projects. The project was originally described in our Jefferson Urology News 2022, and the full text of the widely distributed AUA News article can be found: www.auanews.net/issues/articles/2023/juneextra-2023/medical-student-column-piloting-a-winter-externship-for-preclinical-students-toincrease-exposure-to-urology.

Jefferson Urology Society Officers 2023-2024 President Kerith Wang SKMC 2024 VP Research Yash Shah SKMC 2025 VP Clinical Emily Yanoshak SKMC 2025 Secretary Elizabeth Pavis SKMC 2024 Treasurer Anushka Ghosh SKMC 2026 Upper Class Liaison Xiya Wu SKMC 2025 Lower Class Liaisons John Wahlstedt SKMC 2026 Sohan Shah SKMC 2026

Michael Xu SKMC Class of 2024 Urology Research with Dr. Schiewer Michael Xu is a fourth-year medical student working in Dr. Matthew Schiewer’s laboratory. He is currently studying PARP1, an enzyme that is overexpressed in some advanced prostate cancers, and how over activation and deactivation of PARP1 affects the phenotypes of a prostate cancer model. Before medical school, Michael worked in Dr. Jennifer Doudna’s laboratory at UC Berkley on CRISPR biology and gene editing applications.

Dr. Doudna is a Nobel Laureate in Chemistry who has done pioneering work on CRISPR. At Jefferson, Michael previously worked with Dr. Veronica Rodriguez-Bravo on mechanisms of prostate cancer aggressiveness and Dr. Kevin Kelly on clinical projects relating to prostate cancer immunotherapies. He is currently applying to internal medicine programs for residency and with the goal to specialize in medical oncology.

Michael Xu and Dr. Matt Schiewer, Vice Chair for Basic Science Research. Jefferson Urology

Student News APC Students Join Urology Rotations Advanced Practice Clinicians (APC), sometimes referred to as Advanced Practice Providers (APP), are becoming common members of heath care teams. Such is the case in Urology where PAs (Physicians Assistants or Associates) and NPs (Nurse Practitioners) are often on the front lines of urology care and can increase patient access. Jefferson Urology has long hosted rotating NP students on our inpatient service to work with our well-seasoned NPs Fatuma Doka and Suzanne Barron. According to Associate Professor Dr. Deb Glassman, our APC liaison in the Department of Urology, “It is critical for the urology work force of the future that APCs have exposure to our specialty during their training so that they may develop an interest in working as part of a Urology team.” There are only a handful of centers around the U.S., who offer specific

training programs for urology focused APPs. “Our goal in urology is to offer, in addition to our rotating NP students, opportunities for our Jefferson Health PA students to have a clinical rotation in our Department during their formal training”. Jefferson Health is home to two accredited programs that offer Master’s of Science in Physician Assistant Studies. One program is located in Center City, Philadelphia and the other program is located in two different locations: East Falls section of suburban Philadelphia and Voorhees, New Jersey. As Dr. Glassman states: “We welcome the opportunity to have APP trainees rotate on our inpatient and outpatient services to expose them to our unique specialty and hopefully to consider a full-time career in Urology after graduation.”

Jefferson PA students Jessica Schmidt and Justine Taddini with Dr. Deb Glassman during their Urology rotation in Center City.

Pre-Medicine Enrichment Program, Mid-Atlantic Section American Urological Association The MA-AUA Pre-medicine Enrichment Program (PEP) is a scholarship program developed with the goal of empowering historically underrepresented minorities (URM), who are first-generation students considering medicine. Recipients of this scholarship will be enrolled in a mentoring and support program that focuses on developing key skills within four core areas, which are essential to a successful career in medicine. Those core areas are academic study, career planning, personal growth, and scientific research. In 2023, the Department of Urology received a grant through the Mid-Atlantic AUA to host a PEP student, Sindy Desire. Dr. Whitney Smith, Assistant Professor of Urology, served as Sindy’s mentor over the summer of 2023. Sindy is currently an undergraduate student at Lincoln University in Chester County and in addition to participating in all of our educational conferences, she had the opportunity to shadow in the clinic and in the operating room. Sindy also had the opportunity to attend the Mid Atlantic AUA meeting in Williamsburg in October.

Lincoln University student Sindy Desire with her PEP mentor, Dr. Whitney Smith. 64

Year in Review

Notable SKMC Student Achievements in Urology Anusha Ghosh (SKMC Class of 2025) is the recipient of the Helen and Gabriel Lavine Award Scholarship for outstanding summer research in urology. She conducted numerous reviews and generated meeting abstracts that included reviewing female faculty representation on a variety of urology panels, a

study of intravesical agents for bladder cancer, a study on the management of seminoma and a review of urology centric patient resources online. Sohan Shah, (SKMC Class of 2026) received a research grant award from the American

Urological Association Office of Research. The title of the project is “Novel Method to Reduce Penile Implant Infections Using Inflation and Ultrasound In Vitro”. The project is under the guidance of Dr. Paul Chung, Associate Professor of Urology.

Welcome 2023-2024 Jefferson Urology Research Scholars The Jefferson Urology Research Scholar program was established in 2017 as funded positions that prepare medical students for a urology residency and career as a physician/scientist. Intended as a gap year before Year 4, the one-year, full-time program provides students with opportunities to work alongside urology faculty, garnering invaluable insight while obtaining a career-changing experience. Over the years, scholars have produced dozens of abstracts that have been presented to regional and national meetings with most converted into peer review publications. This year, we welcome SKMC Class of 2025 students Aaron Hochberg and Brian Im. According to Dr. Costas Lallas, program director, “Our Jefferson Urology Research Scholar Program has received national recognition with the number applicants from both SKMC and beyond increasing dramatically. We look forward to continuing the current program design with the possibility of expanding the program through increased philanthropic support in the future.” Brian is originally from Los Angeles, California, and graduated from the University of Southern California majoring in Biology. His current interests in urology are in reconstructive urology and pediatric urology. Brian is eager to conduct research with the department as one of this year’s research scholars. Outside of medicine, he enjoys listening to 90s hip hop, skateboarding, and also his work as a part-time barista.

SKMC students Aaron Hochberg and Brian Im, 2023-2024 Jefferson Urology Research Scholars.

Aaron grew up nearby in Bucks County, Pennsylvania, and later graduated from the Pennsylvania State University with a major in Psychology and a minor in Biology. He became interested in Urology after his 3rd year elective rotation, enjoying the broad nature of the field as well as many techniques utilized by urologists. Aaron is excited to contribute to the field as one of the 2023-2024 research scholars. Outside of his studies, Aaron enjoys finding live music, reading, and traveling when possible.

2023 SKMC Urology Match in Urology According to Dr. Charles Pohl, Senior Vice Provost of Student Affairs and Vice Dean of Student Affairs SKMC, “Congratulations to our Jefferson Urology faculty and our talented group of medical students for another fantastic urology match for 2023 with 100% (5/5) SKMC students matching into this very competitive specialty. The number of interviews granted to our SKMC students was remarkable and above national statistics. I thank and acknowledge the urology faculty that have provided enormous

time and meaningful advice to our SKMC students.” Approximately 145 Urology programs participated in the 2023 Match with more than 500 applicants. With 386 positions listed, all but three were filled in the early Urology match, indicating the highly competitive nature of obtaining a urology residency. There was an 81% match rate nationally for U.S. seniors on the last match cycle.

Listed are the Urology match results for the SKMC Class of 2023 Jessica Bulafka Albert Einstein Medical Center Philadelphia Connor McPartland Temple University Caroline Purcell University of Washington Adam Schneider Thomas Jefferson University Joseph Schultz Virginia Commonwealth Jefferson Urology

Alumni News Gerald Andriole, MD, FACS 2023 Martin L. Dresner, MD, Jefferson Urology Alumni Achievement Award Gerald L. Andriole, Jr., MD, is the recipient of the 2023 Martin L. Dresner, MD, Jefferson Urology Alumni Achievement Award. From 1998 until 2021, Dr. Andriole was the Robert K. Royce Distinguished Professor and Chief of Urologic Surgery at Barnes-Jewish Hospital, the Siteman Cancer Center, and Washington University School of Medicine in St. Louis, Missouri. His most recent academic appointment was Professor and Director of the Brady Urological Institute in the National Capital Region of Johns Hopkins Medicine in Washington, DC. Dr. Andriole has recently retired from the practice of Urology and is now the Chief Medical Officer of Prostatype Genomics. Pictured are Dr. Leonard Gomella with Jefferson Urology Alumni Award winner Dr. Gerry Andriole, his Dr. Andriole, a wife, Dr. Dorothy Andriole, and one of their three sons, Nick. participant in the Penn State-Jefferson Five-Year cancer screening and prevention. He was American College of Surgeons, he has been Accelerated Program, continuously funded by the National Institutes recognized as a member of their Academy received his medical degree from Jefferson of Health starting in1993. Dr. Andriole has of Master Surgical Educators. He has been Medical College (Sidney Kimmel Medical contributed more than 450 peer-reviewed College) in 1978. When he was a Jefferson the recipient of numerous awards, including publications and has served on the editorial medical student, Urology Chair Dr. Paul the outstanding achievement award from the boards of numerous prestigious journals. A few Urologic Oncology Branch of the National Zimskind had just passed away. While the of his major professional roles have included search was on for a new Urology Chair, he Cancer Institute, the Distinguished Clinician Chair of the Prostate Committee of the NCI’s was advised by his faculty mentor, the future Award from Washington University in St. Prostate, Lung, Colorectal, and Ovarian Dean of Jefferson Medical College, Dr. Joseph Louis, and the Richard Williams Award for Gonnella, to rotate on Urology at the University (PLCO) Cancer Screening Trial; Chair of the Prostate Cancer Research Excellence from the Prostate Committee for the Society of Urologic American Urologic Association Urology Care of Pennsylvania. While there, he established a Oncology (SUO) Clinical Trials Consortium; relationship with Dr. Grant Mulholland, who Foundation. and Steering Committee Chair for the would soon become Jefferson’s next Urology REDUCE Trial (Dutasteride Chemoprevention Chair. Gerry went on to surgery training at Jefferson Urology Alumni Awards have been Trial). He also served on the Steering Strong Memorial Hospital and the University previously presented to Drs. Ken Brownstein, Committee of the National Institute of Diabetes of Rochester and completed urology residency Steve Strup, Marty Dresner, Michael Erhard, at Brigham and Women’s Hospital and Harvard and Digestive and Kidney Diseases (NIDDK) and David Rivas. In 2022, the award became Multidisciplinary Approach to Urologic Pelvic Medical School. Subsequently, he was a fellow Pain (MAPP) and Symptoms of Lower Urinary the Martin L. Dresner, MD, Jefferson Urology in Urologic Oncology at the National Cancer Alumni Achievement Award thanks to a Tract Dysfunction Research Network (LURN). Institute in Bethesda, Maryland, from 1983 to gift in honor of Dr. Martin Dresner, 1965 1985. (You can read more about Dr. Andriole graduate of Jefferson Medical College (Sidney Dr. Andriole is a member of the American and the Jefferson Urology NCI Connections Kimmel Medical College). The formal award Urological Association, American Surgical on page 4 of this “2023 Year in Review.”) presentation for Dr. Andriole took place during Association, American Association of our year end David M. Davis Visiting Professor Genitourinary Surgeons, and the Clinical At Washington University, Dr. Andriole had Program on June 16, 2023. Society of Genitourinary Surgeons, among more than 35 years of consistent research contributions in the areas of BPH and prostate others. In addition to being a Fellow in the 66

Year in Review

Updates from Jefferson Urology Alumni

Ganesh Raj, MD, PhD Faculty University of Texas South West (UTSW), Dallas, Texas

graduated from Jefferson with an MD/PhD in 1997, followed by a Urologic residency at Duke and fellowship at Memorial Solan Kettering Cancer Center (MSKCC) in New York. I have been on the faculty at University of Texas South West (UTSW) in Dallas since 2006, where I am currently a professor of Urology and Pharmacology. My clinical interests are largely focused on prostate and bladder cancer, while my funded research interests are in understanding and targeting the molecular drivers of hormone dependent cancers. We have published our innovative approach to target cancer cell signaling by targeting protein-protein interactions. Our recent finding that cancer cells can be targeted by inducing endoplasmic reticulum stress was published in Nature Cancer: rdcu.be/ cOTbz, and is the basis of a startup company EtiraRx, which is starting their first in human clinical trials in breast and ovarian cancers in early 2024. I have been the past President of the Society for Basic Urology Research, Chair of the AUA Research and Grants Committee and currently lead the AUA Nexus Innovations bootcamp. In 2017, I was only the third urologist to be inducted into the prestigious American Society for Clinical Investigations.

grew up in the Philadelphia area and received my undergraduate degree from the University of Chicago and medical degree from the Loyola University of Chicago – Stritch School of Medicine. After completing Surgery and Residency in Urology at Thomas Jefferson University Hospital (2002), I completed a Female Pelvic Medicine and Reconstructive Fellowship at the Cleveland Clinic, Cleveland, Ohio, under the mentorship of former Jefferson Urology Faculty, Dr. Sandip Vasavada. After my fellowship in 2004, I joined the urology faculty at the University of Pennsylvania. In 2009, my family and I moved to University of Florida Department of Urology, Gainesville, Florida, to start the Female Pelvic Medicine & Reconstructive Surgery (FPMRS) program. I have been active in medical education and became the Program Director of the Urology Residency in 2016. In 2023, I was named the Associate Chair of Academic Affairs in the University of Florida Department of Urology.

Louis (Lou) Moy, MD Associate Chair of Academic Affairs in the University of Florida Department of Urology

Jefferson Urology

Alumni News Dr. Frank Keely (left), Indrani (right) with their family.

Francis (Frank) X. Keeley, MD, FRCS (Urology) Public and Private Practices Bristol, England

fter finishing urology residency at Jefferson in 1996 (our first baby was born on the last day of my residency) and an endourology fellowship in Edinburgh, Scotland, we settled in Bristol, England. Bristol is about three hours west of London. We now have three children born in different countries with all living in different countries. I have both a public and a private practice: public (National Health Service) is at the Bristol Urological Institute, Southmead

Dr. Kucherov presenting at the 2023 AUA meeting in Chicago.

Hospital, in Bristol. The private practice is at the Spire Bristol Hospital. My clinical and research interests include kidney cancer, kidney stones, upper tract TCC, and UPJ obstruction. I have served as Secretary of the British Association of Urological Surgeons (BAUS), as well as the Treasurer of the British Journal of Urology International (BJUI) journal. Indrani and I have a large extended family in South Jersey, so we return to the Jersey Shore most summers.

Victor Kucherov, MD Pediatric Urology Fellowship Children's National Hospital Washington, DC

r. Kucherov (Jefferson Urology Residency 2022) reports he is thoroughly enjoying his Pediatric Urology Fellowship at Children's National Hospital in Washington, DC, having had a very productive initial research year. He is also very excited to have signed with the University of Rochester Medical Center in Rochester, New York, as Assistant Professor of Urology to begin in August 2024.

Year in Review

Bob Hong, MD

Private Practice, Lancaster, PA

reetings from Keystone Urology in Lancaster, Pennsylvania. Dr. Gomella asked me to write this update as “Proof of life!” after residency. We just got electricity into our Amish barn, and the horses were acting up, so I had difficulty traveling to the local post office to mail this. Internet is a different world all together along the rolling hills of Lancaster. Enough of the excuses. I have been in Lancaster since completing residency at Jefferson in 1999. At that time, I was one of the first to do a hand-assisted laparoscopic nephrectomy, as well as a HoLEP in Lancaster. My, how the times have changed! Private practice has been nice for my family work balance. My wife (Christine) and I are raising/raised our five children in Lancaster (pictured). It is a great family-oriented environment. They have all thrived, and only two are still at home (we turned the clock

back with our youngest who will be 12 in November). I have been able to take up fly-fishing on the local streams, and there are abundant trails and great outdoor activities. My son got me started in Tae-Kwon-Do, which we did as a father-son experience. He stopped after he got to black belt, but I have continued as I find it great for exercise and balance. We are active in our church community, as is most of the county, and this is reflected in the serene nature of most of the people in Amish country. There were 14 urologists in Lancaster when I first arrived and now there are 9 with one getting ready to retire, so if you are interested in joining a great group with a family-friendly lifestyle and all the amenities, please reach out (all kidding aside, we do have gigabit internet at home). Or, if you are in the Lancaster area to enjoy the scenery, please stop by and say hello.

Drs. Bob and Christine Hong wth their family.

Kymora Scotland, MD, PhD Asst. Professor, Urology, UCLA

JEFFERSON UROLOGY ALUMNI ASSOCIATION Our Jefferson urology alumni including students, residents, fellows, and faculty, should let us know if you have any personal or professional news announcements to share. If you do, please contact Dr. Paul Chung, Director of Jefferson Urology Alumni Association (paul.chung@ jefferson.edu). We are committed to keeping connected to our urology alumni across the United States and internationally. Update your contact and other information by using the following link https://tinyurl.com/ jeffersonurology or by using the QR code below on your cellphone. Alumni may also directly contact our office by phone (215-955-6961) or email Barbara.Devine@ jefferson.edu to update your contact information. Specific questions on the Department of Urology or the Jefferson Urology Alumni Association can be directed to Dr. Paul Chung (paul.chung@jefferson. edu) or Dr. Leonard Gomella, Chair of the Department of Urology (leonard.gomella@ jefferson.edu).

ymora Scotland, MD, PhD, Assistant Professor of Urology at UCLA has been awarded the 2023 AUA Rising Star in Urology. Kymora completed her Urology residency at Jefferson in 2017. This was awarded for her research proposal, “Elucidating the Role of BiofilmForming Bacteria in Nephrolithiasis.” The AUA awards this highly competitive and prestigious grant to one individual in the country each year to provide research funds to supplement the award winner’s K award from the NIH, which is itself incredibly competitive. Kymora was also recently honored as a 2022 Young Urologist of the year by the AUA.

Jefferson Urology Alumni Association QR Code for Directory Updates

Jefferson Urology

In Memoriam: Leonard Frank, MD Dr. Len Frank passed away on February 27, 2023, after a brief illness. He was 87. A 1961 graduate of Hahnemann, he was a surgical intern at the Philadelphia General Hospital and then served as Lieutenant in the U.S. Navy from 1962 to 1964. He completed his urology residency at Jefferson from 1966-1968. In 1997, Dr. Frank joined the Jefferson faculty after retiring from a successful private urology practice in the Philadelphia suburbs. As a true Jeffersonian, Len returned to his alma mater in a variety of teaching roles. Throughout the years, he supervised the former resident’s clinic and our Urology small group student discussions. Len had been an extraordinary volunteer faculty contributor to our medical student learning, an experience that received consistently high marks from our SKMC students. In 2009, he was honored with the Jefferson Medical College (Sidney Kimmel Medical College) Leon A. Peris Award. The award recognizes excellence in teaching and patient care by a member of the volunteer faculty. When he retired from his teaching responsibilities after 20 years of service, the department held a “Second Retirement” celebration on Thursday, March 17, 2016, for Dr. Frank. The program was attended by friends, family, and his former urology practice partners. Beyond their personal teaching commitments, Drs. Len and Barbara Frank were philanthropic supporters of medical education. Dr. Barbara Frank supported the

gastroenterology program at Drexel University with a teaching center named in her honor. At Sidney Kimmel Medical College, Dr. Len Frank helped establish our Jefferson Urology Museum as part of our Department of Urology Centennial celebration in 2004. The Leonard and Barbara Frank Endowment Fund was established through their generosity to support various needs of the Jefferson urology residency program. This has included funding textbooks and supporting regional and national meeting participation. The Franks were also keenly aware of the need to support the well-being of our residents by providing tickets to sporting and theatre events and, most recently, through sponsorship of our residents annual membership to the nearby Planet Fitness on Sansom Street. Len was the beloved husband of the late Dr. Barbara (nee Balis) Frank; loving father of Michael (David Adams); Frank and Bradford (Laura) Frank; cherished grandfather of Eliana, Adeline and Carter Frank; and the devoted brother of the late Harriet Shane. The legacy of Len and Barbara Frank will live on through their endowments supporting educational initiatives. Contributions in Dr. Leonard and Barbara Frank’s memory may be made in support of the Urology Residency Program at Jefferson. Mail to Jefferson, Office of Institutional Advancement, Department 825434, P.O. Box 71331, Philadelphia, PA 19176-1331, or through online contributions at giving.jefferson.edu.

Dr. Leonard Frank and Urology colleagues at the dedication of the Jefferson Museum of Urology named in his honor in 2004. 70

Year in Review

Drs. Barbara and Leonard Frank

The Franks were keenly aware of the need to support the well-being of Jefferson residents by providing tickets to sporting and theatre events and most recently through their legacy fund’s sponsorship of our residents annual membership to the nearby Planet Fitness on Chestnut Street.

Dr. Frank greatly enjoyed working with residents during his 20-year teaching tenure at Jefferson. Here, he is pictured with the urology resident team during his “second retirement” ceremony in 2016.

Year in Photos 1 Dr. JY Leong approving of the Häagen-Dazs ice cream truck treats during the Graduation Celebration in June. 2 “The heart and soul of our department, our official ‘Guardian of Urology’ Janice Harper. Thank you for everything you do for us!” Janice with PGY3 Mauro Dispagna and Denise Tropea.

2 3 Dr. Peter McCue, our longstanding GU pathology expert and research collaborator, retired from Jefferson in 2023. Drs. Kevin Kelly and Leonard Gomella gave him a gift to remember our 30+ year clinical and academic collaboration. 4 Our newest assistant Professor Dr. Paul Bloch admiring the “Welcome New Faculty” display with our newest professor of Urology Dr. Adam Metwalli. For more on Drs. Bloch and Metwalli, see page 71.

4 5 Dr. Paul Bloch’s first Journal club as an attending and also celebrating Dr. Maria D’Amico’s wedding. 6 Our Center City outpatient urology team visited the Honickman Center construction site this past summer. Our new Center City clinical home will be on the 11th floor of the Honickman Center located at 11th and Chestnut.

6 7 Dr. Whitney Smith, Dominque Williams, Vivian Ngo, PA, Jasmine West, Triciann Carr, and Rosa Castillo at our Abington Price office. 8 A spontaneous a capella

rendition of the Eagles fight song during the dinner celebration in honor of Dr. Lallas as the next Nathan Lewis Professor (see page 14). Sadly as we all know, the song did not work in 2023.

Jefferson Urology

Year in Photos 9 Congratulations to Dr. Courtney Capella, PGY-4, and her husband emergency medicine physician Dr. Joseph Godovchik, who were married in Glen Mills, Pennsylvania, on July 22, 2023. 10 2023 was a busy wedding year for the Department of Urology. In addition to our residents Courtney and Maria, Jonathan and Mandy Scroggins were also married. Jonathan is a service award winning member of our Department of Urology practice in New Jersey. 9

10 11 Clotel Harris and her husband, Terri, attended Jefferson Health - New Jersey 2023 Fundraising Gala at the Borgata Hotel in Atlantic City as guests of Dr. Jeanne Llenado. Clotel is a Certified Medical Coder and Biller and has been with the Department of Urology for 22 years with plans to retire in June of 2024.

12 Drs. Bill and Dolores Byrne with Dr. Gerald Grunwald, Dean, Jefferson College of Life Sciences. The picture was on the occasion of Dolores, Assistant Professor of Urology, receiving an award for teaching excellence in Jefferson’s Postbaccalaureate Pre-Professional Program (for details see page 34). 13 Congratulations to Dr. Maria D’Amico, PGY-4, and her husband, Dr. Chase Khan, 4th year ENT Resident at Jefferson on their wedding, September 23, 2023, at Cape May, New Jersey.

14 Paul and Gina Rodriguez, Jaclyn O'Rourke, Rebecca Meisse, Tammy Aversa, Dr. Perry Weiner, Amy Scutti, and Dr. Jeanne Llenado represented the Department of Urology at the 14th Annual Methodist Hospital Foundation Fashion Fundraiser. 13

14 15 Dr. Lallas took his MidAtlantic AUA Presidency very seriously when he presided over the 2023 annual meeting in historic Williamsburg, Virginia (see page 19 for details). 16 The staff at Jefferson

15 72

16 Year in Review

Cherry Hill Hospital hosted a dinner and VIP tour of the facility for our faculty on June 20, 2023. On July 1, our department began inpatient services at Cherry Hill.

21 17 Moriah Cunningham, PhD student in our Schiewer Urology Research Lab, during her annual Research in Progress presentation for her PhD program in Cell Biology and Regenerative Medicine (CBRM). Jefferson’s PhD Graduate Program in CBRM provides students with the background, training, and experience necessary to launch a career as an independent scientific investigator that significantly contributes to the advancement of human health.

18 The Department hosted volunteer Margaux Luvisutto during the fall semester. Margaux is originally from Europe but grew up in Hong

22 Kong. She graduated high school from Westtown School, in Westtown, PA, and will be attending the University of San Francisco on the pre-med track. She worked on many different projects in the Department to gain experience in a clinical hospital setting before starting her medical school journey. Margaux is shown here with her main collaborator, Zoe Brun, and their employee recognition project.

19 Our Cherry Hill office team gathered for a remote video of our department of Urology Town Hall meeting in August: Beverly Scarlett, Leah McDermott, PA, Jonathan Scroggins, Nichol Elliot, Jeffrey Yamane, and Alexis Greene.

20 Our SKMC medical students during a Jefferson Urology Society workshop on the technical aspects of the vasectomy procedure. (See page 62 for details.) 21 Our Center City urology office holiday party featured Dr. Tricia Gomella’s rice crispies holiday tree and an “Ugly Christmas Sweater” contest. Essence Williams was the official contest winner with Dr. Adam Metwalli wearing the first-ever “Ugly Christmas Jacket.” 22 Jefferson Urology residents at their 2023 “Secret Santa” holiday party. Jefferson Urology

Faculty Listing Department of Urology Faculty, Sidney Kimmel Medical College Thomas Jefferson University James Ryan Mark, MD, FACS Assistant Professor Vice Chair for Clinical Research Medical School Director SKCC Biorepository Medical School: Saint Louis University School of Medicine, St. Louis, Missouri Residency: Thomas Jefferson University Hospital Fellowship: Urologic Oncology, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC Adam R. Metwalli, MD Professor Medical School: Wake Forest University School of Medicine Residency: General Surgery – University of Louisville Hospital Urology – Oklahoma University Health Science Center Fellowship Training: Urologic Oncology: National Institutes of Health and University of Texas MD Anderson Cancer Center Alana M. Murphy, MD, FACS Associate Professor Associate Director Urology Residency Program Director Female Urology Medical School: College of Physicians & Surgeons at Columbia University, New York Residency: Columbia University Medical Center, NY, NY Fellowship: Female Pelvic Medicine and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH Leonard G. Gomella, MD, FACS Chairman, Department of Urology The Bernard W. Godwin Jr. Professor of Prostate Cancer Sr. Director Clinical Affairs, Sidney Kimmel Cancer Ctr. Enterprise Vice President Urology, Jefferson Health Medical School: University of Kentucky Residency: University of Kentucky Fellowship: Surgical Oncology, National Cancer Institute, Bethesda, MD Paul Bloch, MD Assistant Professor Medical School: Sidney Kimmel Medical College Residency: University of Tennessee Health Science Center P. Kenneth Brownstein, MD, FACS Clinical Assistant Professor The Harold A. Honickman Physician Director of Jefferson Signature Services Director of Development Medical School: Hahnemann University (now Drexel University College of Medicine), Philadelphia, PA Residency: General Surgery – UCLA, Harbor General HospitalSan Diego, CA Urology Residency: Thomas Jefferson University, Phila., PA Dolores E. Shupp-Byrne, PhD Assistant Professor Director of Medical Student Education Director Jefferson’s Postbaccalaureate Pre-Professional Program (P4) Graduate School: University of Pittsburgh, Pittsburgh, PA Post-Doctoral Fellowship: Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA Paul H. Chung, MD, FACS Associate Professor Co-Director Men’s Health Program Director Reconstructive Urology Trauma and Prosthetics Director Jefferson Urology Alumni Association Medical School: Sidney Kimmel Medical College Residency: University of Texas Southwestern Medical Center, Dallas, Texas Fellowship: Male Genitourinary Reconstructive Surgery and Trauma, University of Washington, Seattle WA Deborah T. Glassman, MD, FACS Clinical Associate Professor Director Telehealth Program and APP Committee Chair Medical School: New York University School of Medicine, New York, NY Residency: University of Maryland, Baltimore, Maryland

Year in Review

Patrick T. Gomella, MD, MPH Assistant Professor Urology and Surgery CME Coordinator Medical School: Sidney Kimmel Medical College Residency: George Washington University Fellowship: Urologic Oncology, National Cancer Institute, Bethesda, MD Irvin H. Hirsch, MD Clinical Professor Co-Director Men’s Health Program Medical School: Mount Sinai School of Medicine, NY Residency: Beth Israel Medical Center, New York, NY Fellowship: Male Reproductive Medicine & Surgery/ Urodynamics & Uroprosthetics Baylor University Medical Center, Houston TX Scott G. Hubosky, MD Demetrius H. Bagley Jr. MD Professor Vice Chair Quality Improvement & Safety Director Division of Endourology/Co-Director Fellowship Program Endourology & Laparoscopy Medical School: Loyola University, Stritch School of Medicine, Chicago Residency: Thomas Jefferson University Hospital Fellowship: Robotic Surgery and Endourology, Eastern Virginia Medical School, Norfolk, VA Joseph K. Izes, MD, FACS Clinical Assistant Professor Medical School: Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA Residency: Lahey Clinic Foundation, Burlington, MA Fellowship: Urologic Oncology, Lahey Clinic, Burlington, MA Costas D. Lallas, MD, FACS The Nathan Lewis Hatfield Professor of Urology Vice Chair, Education Associate Director Urology Residency Program/Co-Director Fellowship Program Endourology & Laparoscopy Program Director, Einstein Urology Residency Program Director Medical School: Sidney Kimmel Medical College Residency: Duke University Fellowship: Robotic Surgery, Mayo Clinic, Scottsdale, AZ Jeanne V. Llenado, DO, FACOS Clinical Assistant Professor, Vice Chair Regional Urology Director, South Philadelphia Campus Medical School: UMDNJ-School of Osteopathic Medicine, Stratford, NJ Residency: UMDNJ, Stratford NJ

Matthew Schiewer, PhD Assistant Professor, Urology & Cancer Biology Vice Chair for Basic Science Research Graduate School: Thomas Jefferson University, Phila., PA Postdoctoral Fellowship: Sidney Kimmel Cancer Center, Philadelphia, PA Mihir S. Shah, MD Clinical Assistant Professor Social Media Coordinator, DEI Faculty SKMC Medical School: Rutgers, The New Jersey Medical School, Newark, NJ Residency: Thomas Jefferson University Hospital Fellowship: Advanced Robotics, Laparoscopy and Urologic Oncology, USC Los Angeles, CA Patrick J. Shenot, MD, FACS Professor Deputy Chair Residency Program Director Medical School: State University of New York Stony Brook Residency: Thomas Jefferson University Fellowship: Neurourology, Thomas Jefferson University Whitney R. Smith, MD Assistant Professor Director DEI, Department of Urology Medical School: Rutgers, The New Jersey Medical School, Newark, NJ Residency: Thomas Jefferson University Hospital Fellowship: Female Pelvic Medicine and Reconstructive Surgery Wake Forest Baptist Health, Winston-Salem, NC Perry R. Weiner, DO, MSc, FACOS Clinical Associate Professor Director Men’s Health Program Medical School: New York College of Osteopathic Medicine, Old Westbury, New York Residency: Philadelphia College of Osteopathic Medicine, Philadelphia, PA DEPARTMENT OF UROLOGY ADMINISTRATOR Megan Sabonjian, MBA, PMP JOINT SIDNEY KIMMEL MEDICAL COLLEGE FACULTY Karolynn Echols, MD, FACOG, FPMRS, FABOIM Associate Professor, Obstetrics and Gynecology and Urology Director, Female Pelvic Medicine & Reconstructive Medicine Department of Obstetrics and Gynecology

Ethan J. Halpern, MD Professor of Radiology and Urology Vice Chair for Research Department of Radiology William Kevin Kelly, DO Professor, Medical Oncology and Urology Chairman Department of Medical Oncology Associate Director of Clinical Research, Sidney Kimmel Cancer Center Mathew L. Thakur, PhD, FSNMMI, FNAI, FACNM, FICNM, FARR Professor of Radiology, Radiation Oncology and Urology Director, Laboratories of Radiopharmaceutical Research, Molecular Imaging and Biofluid Diagnostics

DUPONT NEMOURS PEDIATRIC UROLOGY FACULTY T.E. (Sonny) Figueroa, MD, FAAP, FACS Professor of Urology and Pediatrics Chief, Division of Urology at Nemours/Alfred I. duPont Hospital for Children Fellowship: Children’s Hospital of Michigan, Detroit, MI Pasquale “Pat” Casale, MD, FACS Professor Medical School: Albert Einstein College of Medicine Residency: Thomas Jefferson University Hospital Fellowship: Seattle Children’s Hospital and Medical Center Keara N. DeCotiis, MD Clinical Assistant Professor of Urology Fellowship: The Hospital for Sick Children, Toronto, Canada

Jennifer Hagerty, DO, FAAP Clinical Assistant Professor of Urology and Pediatrics Fellowship: Northwestern University, Ann & Robert H. Lurie Children's Hospital, Chicago, IL Puneeta Ramachandra, MD Clinical Assistant Professor of Urology and Pediatrics Fellowship: Rady Children’s Hospital of San Diego, San Diego, CA VOLUNTEER FACULTY Mohammed Ismail, MD Assistant Professor Chief of Urology, VA Medical Center Wilmington, DE Edouard J. Trabulsi, MD, MBA, FACS Professor Chair, Department of Urology Einstein Medical Center, Philadelphia, PA

Outpatient Practice Locations Jefferson Department of Urology Outpatient Locations

Jefferson’s convenient Navy Yard location at 3 Crescent Drive, with our Department of Urology and Men’s Health Program offices. Abington/Asplundh Cancer Pavilion Sidney Kimmel Cancer Center Site Contact: Noreen Wielgus, MSN, RN 3941 Commerce Avenue, Willow Grove, PA 19090 215-481-4668 | Fax: 215-481-8056 Jefferson Urology Abington Site Contact: Traciann Carr, RN Price Medical Office Building 1245 Highland Avenue, Suite 302 Abington, PA 19001 215-481-7700 | Fax: 215-481-4511 GU Multidisciplinary Clinic Sidney Kimmel Cancer Center Site Contact: Crystal Sypherd, CPhT 215-503-0581 111 S. 11th Street, Street Level Philadelphia, PA 19107 215-955-6700 | Fax: 215-955-0412

The Department of Urology has urologic oncologists who participate in the Sidney Kimmel Cancer Center at the Asplundh Cancer Pavilion in Willow Grove.

Jefferson Urology Center City** Site Contact: Janelle Browning 33 S. 9th Street, Suite 703 (Formerly 833 Chestnut) Philadelphia, PA 19107 215-955-1000 | Fax: 215-503-2066 Jefferson Urology Cherry Hill Site Contact: Beverly Scarlett 2211 Chapel Avenue, #301 Cherry Hill, NJ 08034 844-542-2273 | Fax: 856-667-2428 Jefferson Urology Navy Yard Site Contact: Tammy Aversa 3 Crescent Drive, 2nd Floor Philadelphia, PA 19112 215-503-7124 | Fax: 215-503-3191

Men’s Health Program at the Navy Yard Site Contact: Alana Flowers 3 Crescent Drive, 2nd Floor Philadelphia, PA 19112 215-890-1090 | Fax: 215-503-3191 __________________________ For Pediatric Urology Care Division of Pediatric Urology Nemours Physicians: 302-651-4200 Locations in Delaware, Philadelphia, Main Line and New Jersey ** Effective April , 2024 1101 Chestnut Street, 11th Floor Philadelphia, PA 19107

Jefferson Medical Group Urology Practices Jefferson NE Urology Bucks Jefferson NE Urology Torresdale Jefferson NE Urology Cottman Jefferson NE Urology Welsh Road Buxmont Urological Specialists Buxmont Urological Specialists Einstein Urology Philadelphia

240 Middletown Boulevard 3998 Red Lion Road 1342 Cottman Avenue 2137 Welsh Road 125 Medical Campus Drive 633 West Germantown Pike 1200 W. Tabor Road

Langhorne, PA 19047 Philadelphia, PA 19114 Philadelphia, PA 19111 Philadelphia, PA 19115 Lansdale, PA 19446 Plymouth Meeting, PA 19462 Philadelphia, PA 19141

267-560-1001 215-632-8882 215-745-1612 215-698-7333 215-361-2304 215-257-1050 215-456-4600 Jefferson Urology

Department of Urology Publications 2023 ARTICLES Herzog TJ, Vergote I, Gomella LG, Milenkova T, French T, Tonikian R, Poehlein C, Hussain M. Testing for homologous recombination repair or homologous recombination deficiency for poly (ADP-ribose) polymerase inhibitors: A current perspective. Eur J Cancer. 2023 Jan;179:136-146. doi: 10.1016/j. ejca.2022.10.021. PMID: 36563604. D’Amico M, Wason S, Cozier YC. Correlates of nephrolithiasis in US black women: data from the black women’s health study. Urolithiasis. 2023 Jan 6;51(1):29. doi: 10.1007/s00240-02201391-6. PMID: 36607394. Lin R, Flerova E, Wamsley CE, McCue PA, Lallas CD, Jiang W, Huang J, Wang ZX, Li L. Sarcomatoid renal cell tumor harboring a novel BYSL::TFEB fusion with concurrent TFEB amplification. Genes Chromosomes Cancer. 2023 Jun;62(6):353-360. doi: 10.1002/ gcc.23125. Epub 2023 Feb 3. PMID: 36704911. Prebay ZJ, Foss H, Ebbott D, Hyman J, Li M, Chung PH. Do Sodium-Glucose CoTransporter 2 Inhibitors Increase the Risk of Urologic Implant Reintervention? Urology. 2023 Apr;174:191-195. doi: 10.1016/j. urology.2023.01.032. Epub 2023 Feb 7. PMID: 36754235. Dhital B, Santasusagna S, Kirthika P, Xu M, Li P, Carceles-Cordon M, Soni RK, Li Z, Hendrickson RC, Schiewer MJ, Kelly WK, Sternberg CN, Luo J, Lujambio A, Cordon-Cardo C, Alvarez-Fernandez M, Malumbres M, Huang H, Ertel A, DomingoDomenech J, Rodriguez-Bravo V. Harnessing transcriptionally driven chromosomal instability adaptation to target therapyrefractory lethal prostate cancer. Cell Rep Med. 2023 Feb 21;4(2):100937. doi: 10.1016/j. xcrm.2023.100937. Epub 2023 Feb 13. PMID: 36787737; PMCID: PMC9975292. McCormick BJ, Keihani S, Hagedorn J, Selph JP, Figler BD, Johnsen NV, da Silva RD, Broghammer JA, Gupta S, Miller B, Burks FN, Eswara J, Osterberg EC 3rd, Carney KJ, Erickson BA, Gretzer MB, Chung PH, Harris CR, Murphy GP, Rusilko P, Shridharani A, Benson C, Alwaal A, Blaschko SD, Breyer BN, Amend GM, McKibben M, Elliott SP, Schwartz IW, Simhan J, Vanni AJ, Moses RA, Myers JB. A multicenter prospective cohort study of endoscopic urethral realignment versus suprapubic cystostomy after complete pelvic fracture urethral injury. J Trauma Acute Care Surg. 2023 Feb 1;94(2):344-349. doi: 10.1097/ TA.0000000000003774. Epub 2022 Sep 19. P Prebay ZJ, Ebbott D, Foss H, Li M, Chung PH. A global, propensity-score matched analysis of patients receiving artificial urinary sphincters and the risk of complications, infections, and re-interventions. Transl Androl Urol. 2023 May 31;12(5):832-839. doi: 10.21037/tau-22-631. 76

Year in Review

Epub 2023 Feb 23. PMID: 37305625; PMCID: PMC10251084.MID: 36121280. Leong JY, Ancira J, Bulafka J, Shenot PJ, Das AK, Chung PH. Characterizing the biofilm of artificial urinary sphincters (AUS). Transl Androl Urol. 2023 May 31;12(5):866-873. doi: 10.21037/tau-22-702. Epub 2023 Feb 28. PMID: 37305623; PMCID: PMC10251108. Salib A, Halpern E, Eisenbrey J, Chandrasekar T, Chung PH, Forsberg F, Trabulsi EJ. The evolving role of contrast-enhanced ultrasound in urology: a review. World J Urol. 2023 Mar;41(3):673-678. doi: 10.1007/s00345-02204088-y. PMID: 35969244. Chandrasekar T, Clark CB, Gomella A, Wessner CE, Wang S, Nam K, Liu JB, Forsberg F, Lyshchik A, Halpern E, Mark JR, Lallas CD, Gomella LG, Kania L, Trabulsi EJ, Eisenbrey JR. Volumetric Quantitative Contrast-enhanced Ultrasonography Evaluation of Complex Renal Cysts: An Adjunctive Metric to the Bosniak Classification System to Predict Malignancy. Eur Urol Focus. 2023 Mar;9(2):336-344. doi: 10.1016/j.euf.2022.10.004. Epub 2022 Oct 29. PMID: 36319560. Prebay ZJ, Ostrovsky AM, Buck M, Chung PH. A TriNetX Registry Analysis of the Need for Second Procedures following Index Anterior and Posterior Urethroplasty. J Clin Med. 2023 Mar 5;12(5):2055. doi: 10.3390/ jcm12052055. PMID: 36902842; PMCID: PMC10004265. Prebay ZJ, Foss HE, Wang KR, Chung PH. A narrative review on surgical treatment options for male stress urinary incontinence. Transl Androl Urol. 2023 May 31;12(5):874-886. doi: 10.21037/tau-22-629. Epub 2023 Mar 6. PMID: 37305628; PMCID: PMC10251098. Wamsley CE, Morton A, Roth CG, Izes JK, Li L. Emphysematous pyelonephritis necessitating bilateral radical nephrectomy: A case report and literature review. Urol Case Rep. 2023 Mar 7;47:102376. doi: 10.1016/j.eucr.2023.102376. PMID: 36960082; PMCID: PMC10029357. Ostrovsky AM, Prebay ZJ, Chung PH. Trends in Male and Female Urethral Endoscopic Management and Urethroplasty Using the TriNetX Database. J Clin Med. 2023 Mar 9;12(6):2137. doi: 10.3390/jcm12062137. PMID: 36983140; PMCID: PMC10057331. Wang KR, Shah YB, Simhal RK, Quinn A, Denisenko A, Mann E, Clark J, Raikin J, Lallas CD. The Impact of COVID-19 on the Urology Residency Match and Geographic Proximity of Applicants. Urology. 2023 Jun;176:21-27. doi: 10.1016/j.urology.2023.01.050. Epub 2023 Mar 23. PMID: 36963668; PMCID: PMC10033143. Gordon N, Gallagher PT, Neupane NP, Mandigo AC, McCann JK, Dylgjeri E, Vasilevskaya I, McNair C, Paller CJ, Kelly WK, Knudsen KE, Shafi AA, Schiewer

MJ. PARP inhibition and pharmacological ascorbate demonstrate synergy in castrationresistant prostate cancer. bioRxiv [Preprint]. 2023 Mar 23:2023.03.23.533944. doi: 10.1101/2023.03.23.533944. PMID: 36993449; PMCID: PMC10055378. Gomella LG. Cardio-Oncology, NephroOncology and the Urologic Oncology Collaboration. Can J Urol. 2023 Apr;30(2):11457-11458. PMID: 37074741. Scott ER, Singh A, Quinn AM, Morano S, Karp A, Boyd K, Ho M, Schneider A, McPartland C, Denisenko A, Shumaker A, Clark CB, Chandrasekar T, Mann M, Trabulsi EJ, Desai V, Pugliese R, Lallas CD. The use of individualized 3D-printed models on trainee and patient education, and surgical planning for robotic partial nephrectomies. J Robot Surg. 2023 Apr;17(2):465-472. doi: 10.1007/s11701022-01441-6. PMID: 35781195. Foss HE, Krewson BD, Simhal RK, Wang KR, Shah MS. Squamous cell carcinoma of the renal pelvis masquerading as xanthogranulomatous pyelonephritis. Can J Urol. 2023 Apr;30(2):11502-11504. PMID: 37074750. Simhal RK, Shah YB, Wang KR, Martin J, Shah S, Wright A, D'Amico M, Leong JY, Lallas CD, Shenot PJ, Shah MS, Murphy AM. Gender Diversity in Urology Residency Program Leadership Is Associated With Gender Diversity in Residency Cohort. Urology. 2023 Jul;177:222-226. doi: 10.1016/j. urology.2023.04.002. Epub 2023 Apr 12. PMID: 37059231. Leong JY, Shumaker A, D'mello D, Jones EK, Chung PH. Patient's Experience With Imiquimod for Extramammary Paget Disease. Dermatol Surg. 2023 Jul 1;49(7):706-707. doi: 10.1097/DSS.0000000000003807. Epub 2023 Apr 18. PMID: 37093691. Sartor O, Karrison TG, Sandler HM, Gomella LG, Amin MB, Purdy J, Michalski JM, Garzotto MG, Pervez N, Balogh AG, Rodrigues GB, Souhami L, Reaume MN, Williams SG, Hannan R, Jones CU, Horwitz EM, Rodgers JP, Feng FY, Rosenthal SA. Androgen Deprivation and Radiotherapy with or Without Docetaxel for Localized High-risk Prostate Cancer: Long-term Follow-up from the Randomized NRG Oncology RTOG 0521 Trial. Eur Urol. 2023 Aug;84(2):156-163. doi: 10.1016/j. eururo.2023.04.024. Epub 2023 May 12. PMID: 37179241. Chung PH, Hampson LA. Special series on the surgical management of stress urinary incontinence in men. Transl Androl Urol. 2023 May 31;12(5):829-831. doi: 10.21037/tau2023-01. Epub 2023 May 24. PMID: 37305640; PMCID: PMC10251080. Mark JR, Gomella LG, Lallas CD, Smentkowski KE, Calvaresi A, Handley N,

Den RB, Mille P, Tester WJ, Hoffman-Censits J, Dicker AP, Klonicke E, Halpern E, McCue P, Kelly WK, Trabulsi EJ. Enhancing bladder cancer care through the multidisciplinary clinic approach. Can J Urol. 2023 Jun;30(3):1152611531. PMID: 37344462. Gomella LG. Medications That Scare Me: Urology's Turn. Can J Urol. 2023 Jun;30(3):11520-11521. PMID: 37344460. Chandrasekar T, Denisenko A, Mico V, McPartland C, Shah Y, Mark JR, Lallas CD, Fonshell C, Danella J, Jacobs B, Lanchoney T, Raman JD, Tomaszewski J, Reese A, Singer EA, Ginzburg S, Smaldone M, Uzzo R, Guzzo TJ, Trabulsi EJ. Multiparametric MRI is not sufficient for prostate cancer staging: A single institutional experience validated by a multiinstitutional regional collaborative. Urol Oncol. 2023 Aug;41(8):355.e1-355.e8. doi: 10.1016/j. urolonc.2023.05.004. Epub 2023 Jun 23. PMID: 37357123. Margolin EJ, Schoenfeld D, Miles CH, Merrill SB, Raman JD, Thompson RH, Reese AC, Parekh DJ, Brown ET, Klausner A, Williams DH, Lee RK, Zaslau S, Guzzo TJ, Shenot PJ, Anderson CB, Badalato GM. Longitudinal Changes in the Operative Experience for Junior Urology Residents. Urology. 2023 Sep;179:3238. doi: 10.1016/j.urology.2023.03.064. Epub 2023 Jul 1. PMID: 37400019. Leong JY, Chung PH. Penile prosthesis implantation after radiation therapy for prostate cancer. Transl Androl Urol. 2023 Jul 31;12(7):1045-1046. doi: 10.21037/tau-23-296. Epub 2023 Jul 17. PMID: 37554531; PMCID: PMC10406547. Drobner J, Kaldany A, Shah MS, Ghodoussipour S. The Role of Salvage Radical Prostatectomy in Patients with RadiationResistant Prostate Cancer. Cancers (Basel). 2023 Jul 23;15(14):3734. doi: 10.3390/ cancers15143734. PMID: 37509395; PMCID: PMC10378204. Gomella LG. The Bladder and the Bowel: More Than Just Neighbors. Can J Urol. 2023 Aug;30(4):11583. PMID: 37633283. Enders JJ, Pinto PA, Xu S, Gomella PT, Rothberg M, Noun J, Blake Z, Daneshvar M, Seifabadi R, Nemirovsky D, Hazen L, Garcia C, Li M, Gurram S, Choyke P, Merino MJ, Toubaji A, Turkbey B, Varble N, Wood BJ. A Novel MRI/ultrasound Fusion Prostate Biopsy Technique using Transperineal Ultrasound: An Initial Experience. Journal of Urology. doi. org/10.1016/j.urology.2023.06.036. 2023 Aug 10. PMID: 37572884 Leong JY, Chung PH. Editorial Comment. Urol Pract. 2023 Sep 7:101097UPJ000000000000045601. doi: 10.1097/UPJ.0000000000000456.01. Epub ahead of print. PMID: 37788387.

Santasusagna S, Zhu S, Jawalagatti V, CarcelesCordon M, Ertel A, Garcia-Longarte S, Song WM, Fujiwara N, Li P, Mendizabal I, Petrylak DP, Kelly WK, Reddy EP, Wang L, Schiewer MJ, Lujambio A, Karnes J, Knudsen KE, Cordon-Cardo C, Dong H, Huang H, Carracedo A, Hoshida Y, Rodriguez-Bravo V, Domingo-Domenech J. Master transcription factor reprograming unleashes selective translation promoting castration resistance and immune evasion in lethal prostate cancer. Cancer Discov. 2023 Sep 7. doi: 10.1158/21598290.CD-23-0306. Epub ahead of print. PMID: 37676710. Prebay ZJ, Foss H, Ebbott D, Li M, Chung PH. Oxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX analysis. Int J Impot Res. 2023 Sep 8. doi: 10.1038/s41443-023-00760-y. Epub ahead of print. PMID: 37679464. Thakur ML, Trabulsi EJ, Dale E, Singh V, Chhabra A, Dahlgren O, Kolesnikov O, Wang K, and Gomella LG VPAC targeted optical imaging assay (VPAC assay) of voided urine for management of patients with persistently elevated PSA. JCO Global Oncology 2023 9:Supplement_1, 124 Schostak M, Bradbury A, Briganti A, Gonzalez D, Gomella L, Mateo J, PenaultLlorca F, Stenzinger A, Wyatt AW, Bjartell A. Practical Guidance on Establishing a Molecular Testing Pathway for Alterations in Homologous Recombination Repair Genes in Clinical Practice for Patients with Metastatic Prostate Cancer. Eur Urol Oncol. 2023 Sep 13:S2588-9311(23)00166-9. doi: 10.1016/j. euo.2023.08.004. Epub ahead of print. PMID: 37714762. Gomella LG. Re: Venture capital investment in urology, 2011 to mid-2021. Can J Urol. 2023 Oct;30(5):11667. PMID: 37838993. Gomella LG. Prostate cancer screening algorithms and the Affordable Care Act updates. Can J Urol. 2023 Oct;30(5):11644. PMID: 37838989. Oyer HM, Steck AR, Longen CG, Venkat S, Bayrak K, Munger EB, Fu D, Castagnino PA, Sanders CM, Tancler NA, Mai MT, Myers JP, Schiewer MJ, Chen N, Mostaghel EA, Kim FJ. Sigma1 Regulates Lipid Dropletmediated Redox Homeostasis Required for Prostate Cancer Proliferation. Cancer Res Commun. 2023 Oct 30;3(10):2195-2210. doi: 10.1158/2767-9764.CRC-22-0371. PMID: 37874216; PMCID: PMC10615122. Shah YB, Ghosh A, Hochberg AR, Rapoport E, Lallas CD, Shah MS, Cohen SD. Comparison of ChatGPT and Traditional Patient Education Materials for Men's Health. Urol Pract. 2023 Nov 1:101097UPJ0000000000000490. doi: 10.1097/UPJ.0000000000000490. Online ahead of print. PMID: 37914380

Gomella LG. The Left Shift in Drugs for Advanced Prostate Cancer. Can J Urol. 2023 30(6); 11708-11709 2023 CONFERENCE PRESENTATIONS AND ABSTRACTS For a listing of 2023 AUA Annual Meeting Abstracts and Presentations, Chicago See Page 21 Wang K, D’Amico M, Simhal R, Shah Y, Mark JR, Lallas CD, Shah S, Chandrasekar T, “Perioperative Outcomes for Radical Prostatectomies for Advanced Stage, Node Positive, and Metastatic Prostate Cancer” • Poster presentation at the Society of Women in Urology Conference, Scottsdale, AZ, January 27, 2023 D’Amico M, Simhal R, Wang K, Capella C, Ragam R, Leong JY, Shah Y, Shah M, Shenot PJ, Murphy A, “The Risk Analysis Frailty Index Outperforms the NSQIP Frailty Index in Predicting Risk for Patients Undergoing Sacrocolpopexy” • Podium presentation at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction annual meeting, Nashville, TN, March 9, 2023 Simhal R, Wang K, D’Amico M, Capella C, Ragam R, Leong JY, Shah Y, Shenot PJ, Murphy A, Shah M, “Utilization of Same Day Surgery for Endoscopic Benign Prostatic Hyperplasia Procedures During the COVID-19 Pandemic” • Poster presentation at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction annual meeting, Nashville, TN, March 9, 2023 Simhal R, Wang K, D’Amico M, Capella C, Shah Y, Leong JY, Shah M, Shenot PJ, Murphy A, “Utilization of Same Day Surgery for Minimally Invasive Sacrocolpopexy During the COVID-19 Pandemic” • Poster presentation at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction annual meeting, Nashville, TN, March 9, 2023 Simhal R, Wang K, D’Amico M, Capella C, Shah Y, Leong JY, Shah M, Shenot PJ, A. Murphy, “A Comparison of Outcomes and Patient Characteristics for Sacrocolpopexies Performed by Urologists and Gynecologists” • Poster presentation at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction annual meeting, Nashville, TN, March 9, 2023 Simhal R, Wang K, Capella C, Ragam R, D’Amico M, Shah Y, Leong JY, Shah M, Shenot PJ, Murphy A, “Trends in Surgical Specialty and Utilization of Minimally Invasive Surgery for Sacrocolpopexy from 2006 to 2020” • Poster presentation at the Society of Jefferson Urology

Department of Urology Publications 2023 Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction annual meeting, Nashville, TN, March 9, 2023 Leong JY, Trabulsi E, Gomella LG, Dale E, Lnu A, Tripathi S, Kumari M, Singh V, Dahlgren O, Kolesnikov O, Wang K, Thakur M “Voided Urine Optical Assay to Detect Prostate Cancer: Preliminary Results” • Poster presentation at MA-AUA 2023, Williamsburg, VA October 19, 2023 Simhal R, Shah Y, Wang K, Martin J, Shah S, Wright A, D’Amico M, Leong JY, Lallas CD, Shenot PJ, Shah M, Murphy A “Gender Diversity in Urology Residency Program Leadership is Associated with Gender Diversity in Residency Cohort” • Poster presentation at MA-AUA 2023 Williamsburg, VA October 19, 2023 Shah Y, Beiriger J, Mehta S, Cohen S “CrossSectional Analysis of Educational Materials for Erectile Dysfunction Treatment on TikTok” • Poster presentation at MA-AUA 2023 Williamsburg, VA October 20, 2023 Simhal R, Shah S, Im B, Purtill C, Isguven S, Hickok N, Chung PH “Mechanical Irrigation with Irrisept Effectively Reduces Bacterial Biofilm on Inflatable Penile Prosthesis Surfaces” • Poster presentation at MA-AUA 2023 Williamsburg, VA October 20, 2023 Simhal R, Shah S, Im B, Purtill C, Isguven S, Hickok N, Chung PH “Prophylactic Dipping of Inflatable Penile Prosthesis Material in Irrisept or Antibiotic Inhibits Surface Biofilm Formation” • Poster presentation at MA-AUA 2023 Williamsburg, VA October 20, 2023 Prebay Z, Fu D, Chung PH “The Relationship Between Hypogonadism and Implant Outcomes” • Poster presentation at MA-AUA 2023 Williamsburg, VA October 20, 2023 Ebbott D, Prebay ZJ, Li M, Chung PH “A Propensity-Score Matched Analysis of Patients Receiving Inflatable Penile Prosthesis and the Risk of Complications, Infections, and ReInterventions” • Poster presentation at MA-AUA 2023 Williamsburg, VA October 20, 2023

Simhal RK, Wang KR, Shah YB, Ragam R, Simon DP, Mark JR, Lallas CD, Gomella LG, Shah MS “The Impact of Neoadjuvant Chemotherapy for Bladder Cancer on Radical Cystectomy” • Poster presentation at MA-AUA 2023 Williamsburg, VA October 21, 2023

Henry G, Stuart A, Chung PH, Diaz N, Lentz A, Natale R, Perito P. Predictors of Success with Early Antibiotic Therapy for Penile Implant Infection: Patients from a Prospective Randomized Study Comparing DNA Sequencing versus Traditional Cultures. Sexual Medicine Society North America Annual Meeting (San Diego, CA, 2023 Nov) – Oral presentation.

Bui K, Capella C, Schneider A, Chung PH. Gender disparities exist in the surgical management of Peyronie's disease and urologic prosthetics: An evaluation of ABU surgical case logs. Sexual Medicine Society North America Annual Meeting (San Diego, CA, 2023 Nov) – Moderated poster presentation

Henry G, Henry C, Hollenbach S, Phillips C, Diaz N, Chung, PH. Comparing the Frequencies of Different Species Present in Revision Penile Prostheses Surgery due to Infectious or Non-Infectious Causes. Sexual Medicine Society North America Annual Meeting (San Diego, CA, 2023 Nov) – Oral presentation.

Prebay Z, Fu D, Hochberg AR, Im BH, Shah S, Chung PH. Androgen Deprivation Therapy Does Not Increase Rates for Reintervention, Complication, or Infection in Penile Implant or Artificial Urinary Sphincter Surgery. Sexual Medicine Society North America Annual Meeting (San Diego, CA, 2023) – Oral presentation.

OTHER ACADEMIC PRODUCTS Schneider A, Chung PH. Transgender and Gender Diverse Patient Urologic Care. AUA Medical Student Curriculum. Available: https:// www.auanet.org/meetings-and-education/ for-medical-students/medical-studentscurriculum/transgender-and-gender-diversepatient-care.

Simhal R, Shah S, Im B, Guillame S, Evans R, Hickok R, Chung PH. Prophylactic Dips and Irrigation Solutions Can Considerably Alter the Antimicrobial Efficacy of Inflatable Penile Implant Hydrophilic Surface Coatings. Sexual Medicine Society North America Annual Meeting (San Diego, CA, 2023 Nov) – Oral presentation.

1 Mark, JR, Kelly WK, Hurwitz, M and

Gomella LG. Penile and Urethral Cancer in: Principles and Practice Of Oncology, 12th Edition DeVita, V, Lawrence, S Rosenberg, S (Eds.), Wolters Kluwer, Philadelphia, 2023

Shah S, Im B, Guillame S, Simhal R, Evans R, Hickok N, Chung PH. Antibiotic Solutions Are the Ideal Irrigation Choice for Inflatable Penile Implant Hydrophilic Surfaces. Sexual Medicine Society North America Annual Meeting (San Diego, CA, 2023 Nov) – Oral presentation.

2 Gomella, AA and Gomella, LG. Micro Ultrasound in the management of Prostate Cancer, in (Spanish) Cancer De Prostata, Dr. Luis Mendoza Montoya, Editor Groupo Editorial San Marcos, Peru, 2023

Mandel A, Simhal R, Sholklapper T, Sun K, Poluch M, Wang, K, Shah, Y, Chung, PH. The Impact of Connective Tissue Disorders on Rates of Penile Fracture and Peyronie’s Disease. Sexual Medicine Society North America Annual Meeting (San Diego, CA, 2023 Nov) – Moderated poster presentation.

3 Gomella, LG, Haist, SA (eds.) Gomella and Haists Manual de referencia clinica para estudiantes y residentes (Clinicians Pocket Reference 12th Edition, Spanish Translation) McGraw Hill, New York, NY (2023)

Chung PH, Leong JY, Baris H, Phillips CD, Chisari E, Nickel JC, Parvizi J, Boursi B. “Variations in Urinary Microbiota in Astronauts after a Short Duration Space Mission to the International Space Station” • Poster presentation at MA-AUA 2023 Williamsburg, VA October 20, 2023

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Year in Review

What Patients Are Saying... Here is what patients are saying about our Department of Urology Physicians from Press Ganey Surveys.

Dr. Hirsch has been treating me for 30 plus years. He is kind, caring and I have recommended him to my friends.

Dr. Izes is a spectacular Doctor. His care is beyond excellent. I have been a patient of Dr. Glassman for seven years now. This has been a wonderful experience, and I consider her a first-rate doctor, who always listens to my concerns and provides detailed explanations.

Dr. Shenot is a great doctor and a great person very caring, and I am very comfortable in whatever he recommends. Dr. Chung was the most thorough, clear, and compassionate doctor that I have ever had. Dr. Patrick Gomella is an excellent doctor with excellent training background! Would recommend him to family and friends.

Dr. Weiner was absolutely fantastic both with his care and answering any of my concerns. I would highly recommend him.

Dr. Mark was very thorough very patient with my questions and made me comfortable from the get-go. Jefferson is lucky to have a doctor like him. Dr. Alana Murphy has my utmost respect! She genuinely cares about her patients. It’s hard to find a physician like her these days. Dr. Llenado is very professional and communicative. She explains delicate topics thoroughly and in easy-to-understand vocabulary, she made me feel comfortable.

Dr. Bloch is a new Jefferson doc. Very good recruit, excellent in all respects! I hit the lottery with Dr. Metwalli! I expected nothing less being a patient with Jefferson? But this doctor went above and beyond my expectations! Making me 100% Confident that I will be OK!

I really like Dr. Hubosky. He explains things very well and is patient when asked questions. He even draws picture for us to make things more clear!

Dr. Shah goes above and beyond. I travelled two hours to see him in Philadelphia because he shows how much he cares about his patients. Kudos to Dr. Shah.

Dr. Leonard Gomella treated my wife and I with respect and genuine sincerity. He put my concerns to rest and explained my condition in an easy to understand way. I cannot ask any more from a doctor. Dr. Smith is a wonderful doctor. She patiently listened to me. Thoroughly reviewed my health history, provided me with treatment options, and included me in the decisionmaking process. Jefferson is lucky. Dr. Lallas has been very professional and informative. I appreciate his surgical expertise, and I’m healing well.

Jefferson Urology