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Rationally Designed DNA Assemblies for Biomedical Application

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Nanotechnology in Regenerative Medicine and Drug Delivery Therapy

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Abstract

Based on Watson–Crick base pairing rules, DNA molecules can work as building blocks to fabricate programmable and functional nanostructures. In recent decades, DNA nanotechnology has been developed to construct sophisticated structures and artificial mechanical devices, giving rise to a variety of desired functions and fascinating applications. Featured with rationally designed geometries, precise spatial addressability, as well as marked biocompatibility, DNA-based nanostructures provide promising candidates for drug delivery. In this chapter, we summarize the recent advances of self-assembled DNA-base nanomaterials for the biomedical applications, including molecular imaging and drug delivery both in vitro and in vivo. The remaining challenges and open opportunities are also discussed.

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Authors and Affiliations

  1. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People’s Republic of China

    Qiao Jiang, Qing Liu, Zhaoran Wang & Baoquan Ding

  2. University of Chinese Academy of Sciences, Beijing, People’s Republic of China

    Zhaoran Wang & Baoquan Ding

Authors
  1. Qiao Jiang
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  2. Qing Liu
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  3. Zhaoran Wang
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  4. Baoquan Ding
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Correspondence to Baoquan Ding .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Haiyan Xu

  2. School of Biological Science and Medical Engineering, Southeast University, Nanjing, China

    Ning Gu

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Jiang, Q., Liu, Q., Wang, Z., Ding, B. (2020). Rationally Designed DNA Assemblies for Biomedical Application. In: Xu, H., Gu, N. (eds) Nanotechnology in Regenerative Medicine and Drug Delivery Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-15-5386-8_6

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