NNIT’s Post

PAT - We've all heard about it, but do we know what it is? Watch this on-demand #webinar to see the advantages, challenges, and future development of Process Analytical Technology (PAT) with Marina Kirkitadze (Head of Process Support & PAT Platform, Analytical Sciences at Sanofi), Gabriella Gerzon (Ph.D. Candidate at York University), and Martin Gadsby (Owner & Director of Optimal Industrial Automation). Together, let's learn about the latest innovations in #bioprocessing and how to successfully transition to digital manufacturing: https://lnkd.in/eQe8cUZR #Pharma #ProcessAnalyticalTechnology

Deciding on the mode of operation is not that easy. For manufacturing processes, batch and continuous operations have advantages and disadvantages that are hard to compare. That is why we started the “Mode of Operation Decision-Making Challenge.” In the challenge, we are searching for concepts showcasing: Data-driven approaches to determining productivity and financials of performing a process Support decision-making between batch, fed-batch, or continuous mode operations. What is in for you? You can join a workshop and showcase your decision-making model for either an organic synthesis process or a bioprocess. The best idea wins 10,000 EUR and the chance to present your work to our scientists. Sign up by 30 September 2023 to become part of our operations journey: https://lnkd.in/e5s3iBmG

Join Alex Moldovan’s talk on "Correlating Particle Informatics with Surface Wetting Measurements" at the International Symposium on Industrial Crystallisation. Learn how particle characteristics such as shape, size, and roughness influence manufacturing processes and product performance in industries like pharmaceuticals and agrochemicals. Session: G3 - Process modelling, design & control & digital design 5 📆 8th September ⏰10:55–12.55 (BST) #pharmaindustry #agrochemicals #scientificresearch

Do you want to see the advantages, challenges, and future development of Process Analytical Technology (PAT)? Watch the on-demand #webinar with Marina Kirkitadze (Head of Process Support & PAT Platform, Analytical Sciences at Sanofi), Gabriella Gerzon (Ph.D. Candidate at York University), and Martin Gadsby (Owner & Director of Optimal Industrial Automation) and learn about the latest innovations in #bioprocessing and how to successfully transition to digital manufacturing: https://lnkd.in/eUS-zU9A #Pharma #ProcessAnalyticalTechnology

Esteemed Sartorius colleague nr 3 with a presentation at IFPAC. Michael Roberto will talk about "The Importance of Design of Experiments Fundamentals in Multi-Way Bioreactor Experimentation", Monday, June 5th. Looking forward to seeing you there Michael! Abstract: Lengthy, costly experimentation defines early research and development for cell-based processes. With multiple factors to refine in these processes, it can take hundreds or thousands of experiments to define ideal conditions for cell growth. Given the extensive work that must be done, multi-way bioreactors have seen increased demand due to their ability to significantly reduce experimentation time. As more researchers are conducting more experiments, some fundamentals of experimental methodology must be emphasized to a new generation of scientists. It is critical to use design of experiments (DOE) principles to not just plan experiments, but to model and explain the variation that is observed in the designed experiments as well. Without applying statistical methods to experimental results, it is impossible to interpret the results with any statistical confidence. Given this importance, this talk will review the fundamental concepts of DOE via both theoretical and practical examples. By showing common pitfalls and the keys to success, we hope that researchers will be able to better deliver on the capabilities of multi-way bioreactors and improve development time for their processes. #sartorius #ambr #umetrics #modde #designofexperiments #doe #ML #ifpac #thoughtleadership #processintencification #minibioreactors #bioreactor #bioprocess https://lnkd.in/dXvmJeUy

Want to know about Downstream Process Intensification using Multicolumn Chromatography? Here’s the right webinar platform that will help you get more insight of the process. #downstreamprocessing #chromatography

In the bioprocessing industry, I often see a disconnect between early research and manufacturing, where molecular knowledge gained in early research fails to be transferred to manufacturing. This can result in delays, quality issues, and even failure to bring a product to market. So, how to avoid this disconnect? Here are ten ways: 1. Involve manufacturing experts in early-stage research 2. Standardize processes 3. Proactively and regularly communicate between the teams 4. Streamline data sharing 5. Define critical quality attributes 6. Implement scalable processes 7. Perform pilot studies 8. Evaluate the feasibility of manufacturing processes 9. Provide training and education to all stakeholders 10. Establish clear goals and timelines #cellculture #processdevelopment #bioprocessing #celltherapymanufacturing #cellandgenetherapy #leadbiotech

🌐 Enhancing Process Design and Operations: Feasibility-Focused Optimization Perspectives 📊 When dealing with process design and operations, understanding feasibility and flexibility is paramount. Huayu Tian, Jnana Sai Jagana, Qi Zhang, and Marianthi Ierapetritou present a comprehensive overview of key concepts and computational approaches that delve deep into these crucial aspects. 🧠 This paper delves into cutting-edge topics, emphasizing feasible region evaluation, feasibility-based optimization, and the integration of flexibility requirements. These aspects are pivotal, especially in navigating the complexities of multiple constraints within black-box optimization contexts. 🎯 The study sheds light on the efficient incorporation of constraints through process feasibility evaluation and feasibility-based optimization. By avoiding unnecessary exploration of infeasible spaces, these methods streamline the optimization process, enhancing efficiency and resource utilization. ⚙️ Furthermore, the paper explores the intricate relationship between flexibility analysis and robust optimization, highlighting the potential synergies between the two. These synergies open doors to novel opportunities in the realm of process design and optimization strategies. 🔬 Real-world applications in pharmaceutical design and process scheduling provide concrete contexts, showcasing the practicality and applicability of the presented approaches in industrial settings. 📚 Read the Publication: https://lnkd.in/ekBssstg #ProcessOptimization #FeasibilityAnalysis #FlexibilityOptimization #IndustrialProcesses #ScientificAdvancements 🌐🔬🧪

What good practices have you found to make a difference?

Are you looking for novel measurement techniques for collecting data and a better understanding of your bioprocess? Our upcoming course on Process Analytical Technology (PAT) for Biomanufacturing promises to be a game-changer in bioprocessing. Why Process Analytical Technology (PAT)? ▪ Sensor technology facilitates real-time monitoring and control, enabling seamless implementation of continuous processing methods. ▪ Increased Productivity through process intensification and continuous bioprocessing. ▪ PAT optimizes resource utilization and reduces wastage. Taught by Krist Gernaey, Ulrich Krühne, Pedram Ramin and Carina Lira Gargalo, Process Analytical Technology for Biomanufacturing (11-13 June 2024) surveys visionary aspects of GMP methods, Quality by Design (QbD) principles, and the latest PAT technologies. Participants will gain hands-on experience with novel measurement techniques, advanced analytics, and practical applications like digital twins and software sensors. Register for the course here: https://lnkd.in/eKUQg5Xr