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This work aims to use two medicinal plants of the genus Artemisia to inhibit two enzymes responsible for diabetes: α-amylase and α-glucosidase. Two essential oils EOAH and EOAI were obtained by hydrodistillation, respectively of Artemisia heba-alba asso and of Artemisia ifranensis. Its chemical compositions were made by gas chromatography and it id...
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... chemical composition of essential oils of the genus Artemisia have been listed in several international and national works [18][19][20]. The composition of two essential oils that are the objective of this work identifies 22 compounds in EOAH with a percentage of 73.86% (Table 1) and 23 compounds in EOAI with a percentage of 73.09% (Table 2) with the abundance of oxygenated monoterpene molecules for all oils. The major compounds of EOAH are: α-Thujone (18.34%), ...Similar publications
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... Geraniol's inhibition of mTOR in cancer cells can also reactivate a process known as "autophagy," leading to cell death [181]. Derivatives of β-Caryophyllene have also shown potential in acting through this biochemical pathway against breast and prostate cancers, while α-bisabolol demonstrates activity against pancreatic cancer and β-elemene exhibits effectiveness against stomach and lung cancers [182]. ...
Cancer is one of the leading causes of death worldwide, affecting millions of people each year. Fortunately, the last decades have been marked by considerable advances in the field of cancer therapy. Researchers have discovered many natural substances, some of which are isolated from plants that have promising anti-tumor activity. Among these, essential oils (EOs) and their constituents have been widely studied and shown potent anticancer activities, both in vitro and in vivo. However, despite the promising results, the precise mechanisms of action of EOs and their bioactive compounds are still poorly understood. Further research is needed to better understand these mechanisms, as well as their effectiveness and safety in use. Furthermore, the use of EOs as anticancer drugs is complex, as it requires absolute pharmacodynamic specificity and selectivity, as well as an appropriate formulation for effective administration. In this study, we present a synthesis of recent work on the mechanisms of anticancer action of EOs and their bioactive compounds, examining the results of various in vitro and in vivo studies. We also review future research prospects in this exciting field, as well as potential implications for the development of new cancer drugs.
... GC-MS analysis was performed using a gas chromatograph coupled to a flame ionization detector (FID) (Agilent 7820 Technologies, Santa Clara, CA, USA). The equipment components and operating conditions are shown in Table 1 [18]. Two approaches were used to identify the components: First, by contrasting their GC retention indices (RI), which were Processes 2022, 10, 1785 3 of 14 calculated in relation to the retention times of a series of n-alkanes using linear interpolation, with those of real compounds or data from the literature. ...
Ocimum plants are of great interest to traditional medicine in the history of several civilizations, particularly in terms of chronic human diseases. Essential oils obtained from this genus have also been used as therapeutic agents. In this present work, two plants of the Ocimum species from Djibouti, Ocimum basilicum L. and Ocimum americanum L., were subjected to hydrodistillation to obtain their essential oils. Gas chromatography-mass spectrometry was performed to determine the chemical composition of both essential oils. Linalool (41.2%) and estragole (30.1%) are the major compounds among the 37 compounds that have been identified in the essential oil of Ocimum basilicum L. (EOOB), and carvotanacetol (38.4%) and estragole (27.5%) are the main compounds among the 42 compounds that have been identified in the essential oil of Ocimum americanum L. (EOOA). Morever, the cytotoxic activity of EOs was evaluated against 13 human cancer cell lines (K562, A549, HCT116, PC3, U87-MG, MIA-Paca2, HEK293, NCI-N87, RT4, U2OS, A2780, MRC -5 and JIMT-T1) using a luminescence spectrophotometric method; hence, the oils showed significant cytotoxic activities. The antibacterial activities of the oils were assayed on five Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Streptococcus agalactiae, Staphylococcus epidermidis and Corynebacterium sp.) and seven Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Shigella sonnei, Salmonella enterica sv. Typhimurium and Enterobacter cloacae) by agar disc diffusion methods. Both essential oils exhibited moderate activities against Streptococcus agalactiae, and thus each has an activity against Pseudomonas aeruginosa for EOOB and against Enterobacter cloacae for EOOA, while the others are negative. The findings of this work showed the promising anticancer effects of both oils against total cell lines with a potential for use as natural alternatives to synthetic drugs; however, there was only an antibacterial effect against Streptococcus agalactiae.
... Whereas α-and β-thujones have neurotoxic properties, which makes them limited in practical use. However, some studies supported the use of thujones as the main components of drugs with immunomodulatory, antitumor, antidiabetic and antimicrobial activities (Hold et al., 2000;Lachenmeier and Walch, 2011;Zámboriné Németh and Thi Nguyen, 2020;Mohamed Abdoul-Latif et al., 2021). ...
In the flora of Kazakhstan there are many medicinal plants, of which the genus Artemisia (Asteraceae) includes 81 species. In the current study, chemical composition of essential oil from aerial parts of Artemisia austriaca Jacq. collected from different sites of Northern Kazakhstan was determined using GC-MS analysis. The chemical analysis demonstrated that the oil was dominated by oxygenated monoterpenes amounting to
39.49-59.20% with camphor (7.03-20.52%), 1,8-cineole (8.95-13.55%), α-thujone (3.16-25.78%) and β-thujone (0.87-9.92%) as major constituents. The results also suggested that there was difference in composition as well as amount among different sites depending on pH and organic matter of the soil. Further chemometric analysis using hierarchical cluster analysis (HCA) of A. austriaca essential oil compositions from the published literature as well as the composition from present study were used in order to demonstrate geographical variations in the composition of the essential oils. It showed the existence of two main clusters: mixture of α- and β-thujones (32.5±21.6%) / 1,8-cineole (13.9±7.8%) (Cluster I) and camphor (40.5±17.4%) / 1,8-cineole (19.4±9.5%) (Cluster II).
... An SLB5 column DB 5 ms (30 m, 0.25 mm film thickness) was employed with a 36 min temperature program of 60-320 at 10 • C/min, followed by a 5 min hold at 320 • C. The injector temperature was 250 • C, the flow rate of the carrier gas (helium) was 1 mL/min, and the split ratio was 1:50. The interval of the scan m/z was between 35 and 900, and the identification of the compounds is based on an individual spectrum comparison of each compound in the Shimadzu NIST08 data [24,25]. ...
Citation: Abdoul-Latif, F.M.; Elmi, A.; Merito, A.; Nour, M.; Risler, A.; Ainane, A.; Bignon, J.; Ainane, T.
Terpenes and their derivatives in essential oil have been raising an upstream interest due to their unwavering health-promoting effects and safety profiles, although the individual essential oil components are inadequately assessed for their biological potential. Terpinen-4-ol, a bioactive natural terpene-derivative unambiguously distributed in most essential oil sources, is displaying a very remarkable role as a phytometabolite. This review, therefore, deciphered the health-promoting effects of Terpinen-4-ol in oxidative stress-linked diseases including neurodegenerative disorders, cancers, cardiovascular diseases, diabetes, and inflammatory disorders. Using Google as a search engine, this systematic review unraveled 217 relevant articles out of 857 search results from Web of Science, PubMed, and ScienceDirect. Terpinen-4-ol is reported to increase superoxide dismutase, decrease glutathione-S-transferase and acetylcholine esterase, inhibit NF-κB and NLRP3 inflammasome activation pathway, downregulate the α-amylase activity and increase insulin sensitivity, and substantially inhibit the generation of inflammatory mediators such as IL-1β, IL-6, IL-10. Despite several beneficial actions of Terpinen-4-ol, it has hardly been expedited to use as pharmaceutical therapeutic target for unveiled biological activities. In that context, this review has focused on the role of Terpinen-4-ol in attenuating oxidative stress and stress-linked pathophysiological conditions unravelling a research gap on it to manifest its best pharmaceutical and therapeutic uses.
Diabetes and obesity are critical health concerns in the world, characterized by weak insulin secretion and activity, leading to increased blood glucose concentrations and an accumulation of excess body fat. There are conventional drugs currently used to treat these conditions, but they provide only short periods of glycemic control, are expensive, and are scarcely available in underdeveloped and developing countries. EOs are complex mixtures of aromatic and volatile compounds obtained from plants. They have numerous pharmacological and industrial applications, including anti-cancer, insecticidal, anti-microbial, anti-obesity, and antidiabetic. This review sought to investigate and organize established in vitro, in vivo, ex vivo, and in silico data, highlighting possible mechanisms of action of essential oils to treat and/or manage diabetes and obesity. The results showed that numerous essential oils from plant parts possess antidiabetic and anti-obesity properties, suggesting that essential oils can be exploited as potential antidiabetic and anti-obesity drugs. ARTICLE HISTORY
Diabetes and obesity are critical health concerns in the world, characterized by weak insulin secretion and activity, leading to increased blood glucose concentrations and an accumulation of excess body fat. There are conventional drugs currently used to treat these conditions, but they provide only short periods of glycemic control, are expensive, and are scarcely available in underdeveloped and developing countries. EOs are complex mixtures of aromatic and volatile compounds obtained from plants. They have numerous pharmacological and industrial applications, including anti-cancer, insecticidal, anti-microbial, anti-obesity, and antidiabetic. This review sought to investigate and organize established in vitro, in vivo, ex vivo, and in silico data, highlighting possible mechanisms of action of essential oils to treat and/or manage diabetes and obesity. The results showed that numerous essential oils from plant parts possess antidiabetic and anti-obesity properties, suggesting that essential oils can be exploited as potential antidiabetic and anti-obesity drugs.
