TBCK Antibody (WW-8): sc-81865

TBCK Antibody (WW-8) is an IgG_2a κ mouse monoclonal TBCK antibody (also designated TBCK antibody) that detects the TBCK protein of mouse, rat and human origin by WB, IP, IF and ELISA. TBCK Antibody (WW-8) is available as the non-conjugated anti-TBCK antibody. TBCK (TBC domain-containing protein kinase-like protein) also known as TBCKL or MGC16169 in human and A630047E20Rik in mouse, is an 893 amino acid protein belonging to the protein kinase superfamily. TBCK contains one protein kinase domain, a Rab-GAP TBC domain and one rhodanese domain. Four TBCK isoforms are produced by alternative splicing events, and the gene encoding TBCK maps to human chromosome 4q24. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington′s disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

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References:

1. Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements.  |  Dobson, CM., et al. 2002. Proc Natl Acad Sci U S A. 99: 15554-9. PMID: 12438653
2. Selective neuronal degeneration in Huntington′s disease.  |  Cowan, CM. and Raymond, LA. 2006. Curr Top Dev Biol. 75: 25-71. PMID: 16984809
3. Syndromic craniosynostosis: from history to hydrogen bonds.  |  Cunningham, ML., et al. 2007. Orthod Craniofac Res. 10: 67-81. PMID: 17552943
4. Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.  |  Ruiz-Perez, VL., et al. 2007. Development. 134: 2903-12. PMID: 17660199
5. Growth hormone analysis and treatment in Ellis-van Creveld syndrome.  |  Versteegh, FG., et al. 2007. Am J Med Genet A. 143A: 2113-21. PMID: 17702014
6. Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle.  |  Chandler, RJ., et al. 2007. BMC Med Genet. 8: 64. PMID: 17937813
7. Muenke syndrome (FGFR3-related craniosynostosis): expansion of the phenotype and review of the literature.  |  Doherty, ES., et al. 2007. Am J Med Genet A. 143A: 3204-15. PMID: 18000976
8. Neuroprotective effects of synaptic modulation in Huntington′s disease R6/2 mice.  |  Stack, EC., et al. 2007. J Neurosci. 27: 12908-15. PMID: 18032664
9. Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias.  |  de Frutos, CA., et al. 2007. Dev Cell. 13: 872-83. PMID: 18061568

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBCK Antibody (WW-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TBCK Antibody (WW-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBCK Antibody (WW-8) Specifications

Alternate Product Name

TBCK

Product Clone Name

WW-8

Classification

Primary Antibody

Clonality

Monoclonal Antibody

Antibody Isotype

IgG_2a kappa light chain

Amino Acids

601-701

Epitope Target

TBCK

Epitope Species

human

Product Reactivity/Detection

TBCK

Species Reactivity/Detection

mouse, rat, human

Additional Mammalian Reactivity

N/A

Additional Non-Mammalian Reactivity

N/A

Applications

WB, IP, IF, ELISA

Vialing Information

Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations

1 citations in various scientific publications

Recommended Secondary Detection Reagents

N/A

Available Conjugates/Forms

N/A