CANCER CHEMOTHERAPY ACENAPHTHENE ... - Cancer Research

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CANCER CHEMOTHERAPY 

ACENAPHTHENE 

Havas, L. J. ONCOLITHIC [SIC] ACTIONS OF SOME 

POLYPLOIDOGENICAGENTS (ACENAPHTENE,PODO- 

PHYLLIN AND VITAMIN K) ON PHYTOCARCINOMATA. 

Arch. Biol. Hung., 1948, 18: 132-144. 2 pi. 

27 rets. Abstracted in: CTfein. Abstr., 1951, 

45: 1206b. Acenaphthene and podophyllin 

produced oncolytic effects on phytocarcinomas 

induced in tomato and castor oil plants by 

Bacterium tumefaciens. Vitamin K showed no 

such effects. As a result of acenaphthene 

and bacterial infection, polyploid shoots 

occurred in the tomato plants. 

ACENAPHTHENE, 

Lettre, H. and Stratmann, M. ÃœBERWEITERE 

EINFACHE MITOSEGIFTE, 1-AMINO-ACENAPHTHEN 

UNDDERIVATE. [ADDITIONAL SIMPLE MITOSIS 

POISONS, 1-AMINOACENAPHTHENEAND DERIVA 

TIVES.] Hoppe Seyler Zschr., 1951, 288: 

25-30. 17 refs. 

ACENAPHTHENEQUINONE 

BISULFITE 

Pearson, A. E. and Powell, A. K. THE INHIBI 

TORY EFFECT OF ACENAPHTHENEQUINONEBISULPHITE 

UPONTUMORGROWTHIN MICE. Brit. J. Cancer, 

1955, 9: 204-208. 

ACETAMIDE, 

1-AMINO- 

IODO- 

Friedman, 0. and Rutenburg, A. M. POSSIBLE 

USEFULNESS OF SUBSTITUTED AMINO ACIDS FOR 

TUMOR GROWTH INHIBITION. Proc. Soc. Exp. 

Biol., N. Y., 1950, 74: 764-766. 6 refs. 

Abstracted in: Chem.Tbstr., 1950, 44: 

101581. "When injected intraperitoÃ±eally 

daily in Swiss mice bearing 3-day-old sar 

coma 37, iodoacetamide and N-iodoacetylphenylalanine 

had some retarding action on the 

growth of the tumor. lodoacetylleucine and 

iodoacetyltryptophan had little of any such 

action." - Chem. Abstr. 

ACETIC 

ACID 

Freedlander, B. L., French, F. A. and FÃ¼rst, 

A. EFFECT OF ACETIC ACID HYDRAZIDE ON MAM 

MARY CARCINOMA 755 in C57 BLACK MICE. Proc. 

Soc. Exp. Biol., N. Y., 1954, 86: 788-789. 

5 refs. Acetic acid hydrazide~a~dded to the 

food resulted in moderate growth inhibition 

of transplanted mammary carcinoma in mice. 

Possible modes of action are discussed. 

ACETIC ACID, 3-INDOLE- 

BaraÃ±ao, A. C. CONTRIBUCIÃ“N AL ESTUDIO DEL 

Ã•CIDO 3-INDOLACETICO; SU RELACIÃ“N CON EL 

CANCER. [CONTRIBUTION TO THE STUDY OF 3- 

INDOLACETIC ACID; RELATION TO CANCER.] 

DÃa mÃ©d., B. Air., 1953, 25: 1761-1765. 

62 refs. 3-indole acrtic acid had antiblastic 

effects both in vitro and in vivo 

experiments. 

ACETIC ACID, IODO- 

See 

122 

3236 

1000 

3252 

ACETIC ACID, MONOIODO- 

See 

1893 2974 

ACETIC ACID, TRICHLOR- 

2717 3134 3135 

Darcissac, M. L'ACIDE TRICHLORACETIQUE DANS 

LA THÃ‰RAPEUTIQUE DU CANCER. [THE TREATMENT 

OF CANCER WITH TRICHLORACETIC ACID.] Acta 

UniÃ³ internat, cancr., Louvain, 1953, !>: 

83-84. 

ACETONE, 

FURFURYLIDENE- 

Furst A., Cutting, W. C. and Dreisbach, R. H. 

EFFECT OF FURFURALACETONE AND RELATED COM 

POUNDS ON EHRLICH ASCITES TUMOR. Stanford 

M. Bull., 1954, 12: 190-194. 7 refs. 

Abstracted in: CKern. Abstr., 1955, 49: 515e. 

"Sixty compounds related to furfuryTTdeneacetone(furfuralacetone) 

were tested for 

neoplastic activity on Ehrlich aacites tumor 

in Webster mice. Furfurylideneacetone, 

tetrahydrofurfurylideneacetone, furfurylidene 

mesityl oxide, vanillylidenemesityl oxide, 

and 4-(3-cyclohexenyl)-3-buten-2-one caused 

a 3-day increase in the life span. Of 5 

recognized neoplastic compounds only triethylenemelamine 

showed greater activity." 

- Chem. Abstr. 

ACIDS, 

DIBASIC 

10 Woodhouse, D. L. CHEMOTHERAPY INVESTIGATIONS 

IN CANCER. WITH REFERENCE TO THE INFLUENCE 

OF CERTAIN ORGANIC DIBASIC ACIDS, DIAMINO 

COMPOUNDS AND NITRO COMPOUNDS ON TUMORS IN 

MICE. Cancer Res., 1947, 7: 398-401. 11 

refs. 

ACETIC ACID, AMNOsee 

GLYCINE 

ACETIC ACID, 2,4-DICHLOROPHENOXY- 

BERNA 

- THERAPY 

Bucher, N. L. R. EFFECTS OF 2,4-DICHLORO- 

PHENOXYACETIC ACID ON EXPERIMENTAL ANIMALS. 

Proc. Soc. Exp. Biol., N.Y., 1946, 63: 204- 

205. 8 refs. The growth rates of 2~transplantable 

mouse sarcomas (Sarcoma 180 and 

Sarcoma 37) were not influenced to any not 

able degree by repeated injections of 2,4- 

dichlorophenoxyacetic acid. 

11 

Jentzer, A. DIVERSES FORMES DE CANCER TRAITEES 

A L'ACININE. [DIFFERENT FORMS OF CANCER TREAT 

ED WITH ACININ.] Oncologia, Basel, 1953, 6: 

286-298. 7 refs. Acinin treatment in 12 

cases of various inoperable neoplasms is de 

scribed. A favorable effect on the subjective 

condition and partly on the general condition 

was noted, but there was no effect on pain or 

on tumor growth, which continued until death.



ACININ BERNA â€”¿ THERAPY 

(Continued) 

12 

Kretz., J. KREBSBEHANDLUNG Â«IT ACININ-BERNA. 

[CANCER TREATMENT WITH ACININ BERNA.] 

Krebsarzt, Wien, 1949, 4: 205-207. 

13 

Kretz, J. ÃœBER WEITERE ERFAHRUNGEN HIT ACININ 

BERNA BEI DER BEHANDLUNG KREBSKRANKER. [FUR 

THER DATA ON ACININ BERNA IN THE TREATMENT 

OF CANCER.] Krebsarzt, Wien, 1954, 9: 94-97. 

5 refs. "Although Acinin does not influence 

cell division of the cancer cell directly, 

one may observe during Acinin treatment a 

slowing down, sometimes also an arrest, of 

the tumor growth, and in combination with 

other chemotherapeutic agents, a regression 

of the tumors." It is suggested that com 

bined treatment may transform an invasive 

into a latent tumor. 

14 Â«Wetzel, J. DIE UNWIRKSAMKEIT VON 'ACININ BERNA' 

ALS KREBSHEILMITTEL BEIM SUBKUTANEN EHRLICH 

KARZINOM DER WEISSEN MAUS. [INEFFECTIVENESS 

OF lACININ BERNA' TO CURE SUBCUTANEOUS EHRLICH 

CARCINOMA IN WHITE MICE.] Oncologia, Basel, 

1953, 6: 260-285. Abstracted in: Excerpta 

med., Sect. 16, 1954, 2: No. 1648; Chem. Abstr., 

1954, 48: 3585h. 

ACONITINE 

Shirasaki, K. EFFECT OF SEVERALMEDICAMENTS 

ON THE YOSHIDA-SARCOMA. Igaku & seibutugaku, 

Abstr.~1952, 

1951, 21: 230-231. 

46: 10442e. 

Abstracted in: Chem. 

16 

Rondoni, P. and Neceo, A. THE COLCHICINE-LIKE 

ACTION OF AN ACRIDINE DERIVATIVE. Experientia, 

Basel, 1951, 7: 142-144. 3 refs. 

ACREDINE, 6-CHLORO-8 (4-DIETHYLAMINO-l- 

METHYLBUTYLAMINO)-METHOXY- 

ACRIDINE, 6-CHLORO-2-METHOXY-9-a-DIETHYL- 

AMINO-i- PENTYLAMINO-, 

see also QUINACRINE 

17 Monesi, V. AZIONE COLCHICINO-SIMILE DI UN DERIVATO 

ACRIDINICO E AZIONE COMBINATA DI TALE COMPOSTO 

E DI COLCHICINA SOPRA LE CELLULE EMOPOIETICA 

DELL'EMBRIONE DI POLLO. [COLCHICINE-LIKE EFFECTS 

OF AN ACRIDINE DERIVATIVE AND THE COMBINED ACTION 

OF THESE COMPOUNDS WITH COLCHICINE ON THE HEMO- 

POIETIC CELLS OF THE CHICK EMBRYO.] Tumori, 

Milano, 1955, Â«J 158-167. 15 refs. English 

summary. 

ACRIDINES â€”¿ EFFECT ON NORMAL GROWTH 

18 

Lasnitzki, I. and Wilkinson, J. H. THE EFFECT 

OF ACRIDINE DERIVATIVES ON GROWTH AND MITOSIS 

OF CELLS IN VITRO. Brit. J. Cancer, 1948, 

2: 369-375. 8 refs. 

19 O'Connor, R. J. THE EFFECT OF ACRIDINE COMPOUNDS 

ON MITOSIS ANDOXYGENCONSUMPTIONIN THE ISO 

LATED BRAIN OF THE EMBRYONICCHICK. Brit. J. 

Exp. Path., 1949, 3Â£: 30-34. 5-amino-l-phenyl- 

10-methyl-acridinium bromide, 5-amino-10 methylacridinium 

bromide, 5-amino-acridine hydrochloride 

and S-ainino-2-trif luoromethylacridine 

hydrochlrode inhibited mitosis in concentrations 

ranging from 0.7-1.8 mg per 100 ml with little 

or no inhibition of respiration. At higher and 

equal concentrations the inhibition of respi 

ration ranged from nil to 100%. The effects on 

mitosis and on respiration are independent. 

EFFECT 

ON TUMOR GROWTH 

20 Garattini, s., Mor, C., Panizzari, G. P. and 

Vegeto, A. SUGLI EFFETTI DI ALCUNE ASSOCI 

AZIONI CON IL 'TEM< NEI CONFRONTI DEL CARCI 

NOMA DI WALKER. [THE EFFECTS OF SOME SUB 

STANCES IN COMBINATION WITH TRIETHYLMELAMINE 

ON WALKER CARCINOMA.] Atti Soc. lombard, 

sci. med., 1954, 9: 120-124. English summary. 

Abstracted in: Excerpta med., Sect. 16, 1955, 

3: No. 1265; Chem. Abstr., 1955, 49: 1211h. 

21 

Lewis, M. R. and Goland, P. P. IN VIVO STAIN 

ING AND RETARDATION OF TUMOURS IN MICE BY 

ACRIDINE COMPOUNDS. Am. J. M. Se., 1948, 

215: 282-289. 22 refs. 

ACRIFLAVINE â€”¿EFFECT ON NORMAL GROWTH 

22 

Bauch, R. TRYPAFLAVIN ALS TYPUS DER CHROMO 

SOMENGIFTE. [TRYPAFLAVIN AS A TYPE OF 

CHROMOSOME POISON.] Naturwissenschaften, 

1947, 34: 346-347. 3 refs. Abstracted 

in: Excerpta med., Sect. 5, 1949, 2: No. 

1999. 

See 

Bucher, O. ZUR WIRKUNG EINIGER MITOSEGIFTE AUF 

DIE GEWEBEKULTUR. [ACTION OF MITOTIC POISONS 

IN TISSUE CULTURE.] Sang, Par., 1950, 2_1: 

382-389. 38 refs. Abstracted in: Excerpta 

med., Sect. 5, 1951, 4: No. 1774. 

1088a 2950 

EFFECT 

TO 

ON NORMAL GROWTH, COUNTERACTION 

24 LettrÃ©, H. and LettrÃ©, R. AUFHEBUNG DER WIRKUNG 

VON MITOSEGIFTEN DURCH CHEMISCHE FAKTOREN. 

[NEUTRALIZATION OF THE EFFECT OF MITOSIS POI 

SONS BY CHEMICAL FACTORS.] Naturwissenschaften, 

1946, 33: 283-284. The mitosis poisoning ef 

fect of~trypaflavin and proflavin was completely 

neutralized by yeast nucleic acid in chicken 

heart fibroblasts. With 2.7 g per cc of proflavin, 

growth stopped completely, but it was 

restored with the additional use of 1.6 or 

more mg. per cc. of yeast nucleic acid. 

25 Massart, L. and Schoon, J. CATION ANTAGONISM 

IN CHEMOTHERAPY.Arch, internat, pharm. 

dyn., Par., 1951, 88J 268-270. 

EFFECT ON TUMOR GROWTH 

26 Klein, G. USE OF THE EHRLICH ASCITES TUMOR OF 

MICE FOR QUANTITATIVE STUDIES ON THE GROWTH 

AND BIOCHEMISTRY OF NEOPLASTIC CELLS. Cancer, 

N. Y., 1950, 3: 1052-1061. 

See 

922 1775 2994 2995



ACRIFLAVDJE â€”¿METABOLISM (INCLUDING EFFECTS 

ON METABOLIC PROCESSES) 

27 

Petronelli, A. L'ACIDO RIBONUCLEINICO NEL CITO 

PLASMA DELLE CELLULE DI ALCUNI ORGANI DI CAVIA 

DURANTE LA REAZIONE CARIOCLASICA DA TRIPAFLA- 

VINA E DA COLCHICINA. [RIBONUCLEIC ACID CON 

TENT OF THE CYTOPLASM IN ORGANS OF THE GUINEA- 

PIG DURING THE KARYOCLASTIC REACTION TO TRYPA- 

FLAVIN OR COLCHICINE.] Sperimentale, 1948- 

1949, 99: 539-549. 53 reÃs. Abstracted in: 

Chera. 5b~str., 1950,-44: 4585e. 

See: 

26 820 

MODE 

OF ACTION 

28 

Bauch, R. TRYPAFLAVIN ALS TYPUS DER CHROMOSO 

MENGIFTE. [TRYPAFLAVINE AS A TYPE OF CHROMO 

SOME POISON]. Naturwissenschaften, 1947, 34: 

346-347. 3 reÃs. Abstracted in: Excerpta 

ned., Sect. 5, 1949, 2: No. 1999. 

PHARMACOLOGICAL AND PHYSIOLOGICAL EFFECTS 

29 

Hascart, P. SUR LES RAPPORTS ENTRE LA RÃ‰ACTION 

DE SELYE ET LE CHOC CARYOCLASIQUE DE DUSTIN 

[RELATION BETWEEN SELYE'S ALARM REACTION AND 

DUSTIN'S KARYOKLASTIC SHOCK.] C. rend. Soc. 

biol., 1949, 143: 985-987. 

See: 

831 847 3560a 

ACTINOLEUKIN 

29a 

Ueda, M., Tanigawa, Y., Okaml, Y., and 

Umezawa, H. A NEWTOXIC ANTIBIOTIC, 

ACTINOLEUKIN, PRODUCEDBY A STREPTO- 

MYCETE. J. Antibiotics, Ser. A, 1954, 

7:125-126. 2 reÃs. In English. 

ACTINOMYCETES â€”¿ EFFECT 

MICROORGANISMS 

ON GROWTH OF 

30 

Takeuchi, T. BACTERIOLOGICAL STUDIES ON ACTINO 

MYCETES PRODUCTS EXHIBITING ANTI-TUMOR ACTI 

VITY. I. ON ANTIMICROBIAL EFFECTS OF SYN 

THETIC ANTI-TUMOR SUBSTANCES AND ANTIMICRO 

BIAL SPECTRA OF ACTINOMYCETES SCREENED FOR 

THE ANTI-TUMOR ACTIVITY. J. Antibiotics 

ser. A, Tokyo, 1954, 7: 29-36. 12 refs. 

In English. 


3003 

ACTINOMYCIN C â€”¿ EFFECT 


31 

Hackmann, C. EXPERIMENTELLE UNTERSUCHUNGEN ÃœBER 

DIE WIRKUNG VON ACTINOMYCIN C (HBF 386) BEI 

BÃ–SARTIGEN GESCHWÃœLSTEN. [EXPERIMENTAL STUDY 

OF THE EFFECT OF ACTINOMYCIN C (HBF 386) ON 

MALIGNANT TUMORS.] Zschr. Krebsforsch., 1952, 

58: 607-613. 14 refs. Abstracted in: Biol. 

XÃ¯Ã¯str.,Bait., 1954, 28: No. 6060; Chem. 

Abstr., 1953, 47: 288Bg. 

32 

Hackmann, C. HBF 386 (ACTINOMYCIN C), EIN 

CYTOSTATISCH WIRKSAMER NATURSTOFF. [HBF 386 

(ACTINOMYCIN C), A CYTOSTATIC NATURAL 

MATERIAL.] Strahlentherapie, 1953, 90: 

296-300. 7 refs. "Filtrates and biÃcatalysts 

from fungus cultures were examined with respect 

to their influence on experimental malignant 

tumors. From among the preparations examined 

actinomycin C in particular was found to 

possess remarkable qualities. Apart from 

its distinct oytostatic effect, this natural 

substance has also a very pronounced inhi 

bitory effect, particularly on the lymphatic 

system." 

See 

1855a THERAPY 

33 Barnard, R. D. ACTINOMYCIN C AND OTHER ANTI- 

BACTERIALS IN HODGKIN'S DISEASE. (CORRES 

PONDENCE). N. York State J. M., 1954, 54: 

1080-1081. 8 refs. 

34 Bertrand-Fontaine. [Tl. Mallarme. J., Schneider, 

J. and Debray, J. ESSAIS DE TRAITEMENT DE LA 

MALADIE DE HODGKIN PAR L1ACTINOMYCINE. 

[ATTEMPT TO TREAT HODGKIN'S DISEASE WITH 

ACTINOMYCIN C.] Presse mÃ©d., 1954, 62: 737- 

738. Actinomycin C was without any Ã«Tfect 

in 14 of 15 cases. The drug is Judged to 

be inferior to any of the "classical" thera 

pies for Hodgkin's disease. 

35 Bollag, W. and Essellier, A. F. ERFAHRUNGEN 

MIT ACTINOMYCIN C. [EXPERIENCE WITH ACTI- 

NOMYCIN C.] Schweiz, med. Wschr., 1954, 

84: 1174-1175. 11 refs. 

36 Clatro Sagastume, L. and BarÃ³n, M. LA ACTI- 

NOMICINA EN EL TRATAMIENTO DEL LINFOGRANULOMA 

MALIGNO: 10 CASOS. [ACTINOMYCIN IN THE TREAT 

MENT OF MALIGNANT LYMPHOGRANULOMA: 10 CASES.] 

Rev. As. mÃ©d. argent., 1954, 68: 537-9. 

37 

Croizat, P. ESSAIS THÃ‰RAPEUTIQUES CONCERNANT 

L'ACTINOMYCINE C.] C. Presse [THERAPEUTIC mÃ©"d.,1954, TRIALS 62: WITH 738. 

Actinomycin C administered in doses 5T 300- 

40O 

had 

g. daily intravenously for 20-25 days 

little effect in 16 cases of Hodgkin's 

disease, 6 of lymphosarcoma, 4 of retothelial 

sarcoma, 1 Ewing tumor and 1 carcinoma. 

38 

Gernez-Rieux, C. and Goudemand, M. PREMIERS 

RÃ‰SULTATS DE L'EMPLOI DE L'ACTINOMYCINE C 

EN THERAPEUTIQUE. [PRELIMINARY 

TREATMENT WITH ACTINOMYCIN C.] 

RESULTS OF 

Presse mÃ©d., 

1954, 62: 739-740. Temporary improvements 

were ncTed in one of 3 cases of Hodgkin's 

disease treated with actinomycin C. A 

case of pulmonary carcinoma and 2 of acute 

leukemia did not respond to actinomycin.



ACTINOMYCIN C â€”¿ THERAPY 

(Continued) 

39 

40 

42 

Huguenin, H , Truhaut, Fi, and Bourdin, J.-S. 

EXPERIMENTATION DE L'ACTINOMYCINE. [EXPERI 

MENTS WITH ACTINOMYCIN.] Presse med., 1954, 

62: 740. Thirty cases of malignant tumor 

were treated with 300-400/ug. actinomycin 

daily for 2 weeks to a month. Four of 21 

cases of Hodgkin's disease showed temporary 

improvement; 4 cases of lymphosarcoma, 1 of 

lymphatic leukemia and 4 of various carci 

noma did not respond to treatment. The 

effect of actinomycin on Hodgkin's disease 

is considered to be inferior to that of 

nitrogen mustard and especially radiotherapy. 

Janbon, M. PREMIERS RESULTATS DE L'APPLICATION 

DE L'ACTINOIIYCINE C EN THERAPEUTIQUE. [PRE 

LIMINARY RESULTS OF ACTINOMYCIN C THERAPY.] 

Presse mÃ©d., 1954, 62: 741. None of the 14 

cases described, including Hodgkin's disease, 

acute leucosis, chronic lymphatic leukemia 

and malignant reticulosis, exhibited more 

than transient beneficial effects from the 

therapy. 

I 

Johne, H. 0. and Kroher, A. ÃœBER DIE BEHANDLUNG 

DER LYMPHOGRANULOMATOSIS MALIGNA (HODGKIN- 

STERNBERG) MIT AKTINOMYCIN C. TREATMENT OF 

LYMPHOGRANULOMATOSIS MALIGNA (HODGKIN-STERNBERG) 

WITH ACTINOMYCIN C.] Dermatologica, Basel, 1954, 

109: 286-294. Approx. 30 reÃs. 

Kasdorf, H. and Ferrari, M. ENSAYOS CLÃ•NICOS 

CON LA ACTINOMICINA C (SANAMICINA BAYER). 

[CLINICAL EXPERIMENTS WITH ACTINOMYCIN C.] 

Arch. urug. med., 1954, 44: 233-248. tab. 

9 refs. English summary. No beneficial 

effects were obtained in either 10 cases of 

advanced Hodgkin's disease or in 2 cases of 

chronic lymphatic leukemia. Moderate bene 

ficial results were obtained in 5 cases of 

generalized lymphosarcoma. 

43 

Martin, H. ERFAHRUNGEN BEI DER BEHANDLUNG DER 

LYMPHOGRANULOMATOSE MIT AKTINOMYCIN C (SANA 

MYCIN). [EXPERIENCES IN THERAPY OF LYMPHO 

GRANULOMATOSIS WITH ACTINOMYCIN C (SANAMYCIN).] 

Klin. Wschr., 1954, 32: 518-522. 8 refs. 

44 

Martin, R. and Munier, J..-P. PREMIERS RÃ‰SULTATS 

DE 12 MALADIES DE HODGKIN TRAITÃ‰S PAR L'ACTINO- 

MYCINE C. [PRELIMINARY RESULTS IN 12 CASES OF 

HODGKIN'S DISEASE TREATED WITH ACTINOMYCIN C.] 

Presse med., 1954, 62: 741-742. No beneficial 

results were obtained by the administration 

of the drug in daily doses of 100-200yug, apart 

from transient shrinking of lymph nodes and 

peritumoral tissue. The effects of the drug 

is judged to be inferior to those obtained by 

x-ray, nitrogen mustard or cortisone. 

45 

Nitsch, W. and Thein, K. BEITRAG ZUR BEHANDLUNG 

DER LYMPHOGRANULOMATOSE MIT SANAMYCIN. [TREAT 

MENT OF LYMPHOGRANULOMATOSIS WITH SANAMYCIN.] 

Ther. Gegenwart, 1955, 94: 49-51. 

46 

Olmer. J. ESSAIS DE TRAITEMENT DE CERTAINES 

HEMOPATHIES MALIGNES PAR L'ACTINOMYCINE C. 

[TREATMENT OF MALIGNANT 

ACTINOMYCIN C.] Presse 

HAEMOPATHY WITH 

mÃ©d., 1954, 62: 742- 

743. In 4 cases of Hodgkin's disease the 

drug did not yield any result if administered 

alone, but combination with cortisone or ra 

diotherapy gave transient improvement. In 

3 cases of malignant reticulosis no results 

were obtained when administered alone. 

one case of Brill-Symmers' disease the 

In 

im 

mediate effects seemed gaod. 

47 

Â»Osten, W. and Zademack KLINISCHE ERFAHRUNGEN 

MIT SANAMYCIN BEI LYMPHOGRANULOMATOSE. [CLI 

NICAL EXPERIENCE WITH SANAMYCIN IN LYMPHOGRA 

NULOMATOSIS.] 687-689. Medizinische, ,â€¢â€¢..... 

1955, No. 18 

Ravina, A. L'ACTINOMYCINE C ET SON ACTION ANTI 

TUMORALE. [ACTINOMYCIN C AND ITS ANTI-CANCER 

EFFECT.] Presse med., 1953, 63: 1270-1272 

10 refs. 

49 

Ravina, A. and Pestel, M. PREMIERS RÃ‰SULTATS 

DU TRAITEMENT DE LA MALADIE DE HODGKIN ET 

DES TUMEURS MALIGNES PAR L'ACTINOMYCINE C. 

[PRELIMINARY RESULTS OF TREATMENT OF HODGKIN'S 

DISEASE AND MALIGNANT TUMOURS WITH ACTINOMYCIN 

C.] Presse mÃ©d., 1954, 62: 743-744. Four 

cases of Hodgkin's disease, 11 of various 

malignant tumours and 1 of Brill-Symmers' 

disease are reported. In Hodgkin's disease 

the results were transient. The drug has no 

effect on the development of a primary tumour. 

However, in neoplasms of the reticular system 

and in mÃ©tastases of various tumours results 

were obtained the importance of which is not 

yet established. 

50 

Ravina, A., Pestel, M. and Thielen, R. APPLI 

CATIONS CLINIQUES DES PROPRIÃ‰TÃ‰SCYTOSTATIQUES 

ET ANTITUMORALES DE L'ACTINOMYCINE C (SANAMYCIN);, 

INTÃ‰RÃŠTD'UNE NOUVELLE MÃ‰THODE D'ADMINISTRATION. 

[CLINICAL APPLICATIONS OF THE CYTOSTATIC AND 

ANTI-NEOPLASTIC PROPERTIES OF ACTINOMYCIN C 

('SANAMYCIN'); A NEW METHOD OF ADMINISTRATION.] 

Presse mÃ©d., 1954, 62: 1159-1160. 12 refs. 

Abstracted in: Excerpta med., Sect. 16. 1955, 

3: No. 1846. 

Schmidt, H., Loosen, H. and Keinen, W. SANA 

MYCIN (ACTINOMYCIN C) IN DER BEHANDLUNG 

BÃ–SARTIGER GESCHWÃœLSTE UND DER LYMPHOGRANU 

LOMATOSE. [SANAMYCIN (ACTINOMYCIN C) IN THE 

TREATMENT OF MALIGNANT TUMORS AND LYMPHOGRA 

NULOMATOSIS.] Deut. med. Wschr., 1955, 80: 

140-143. 13 refs. 

52 Schulte, G. ERFAHRUNGEN MIT NEUEN CYTOSTA- 

TISCHEN MITTELN BEI HÃ„MOBLASTOSEN UND CARCI- 

NOMEN UND DIE ABGRENZUNG IHRER WIRKUNGEN 

GEGEN RÃ–NTGENTHERAPIE. [EXPERIENCES WITH 

NE* CYTOSTATIC AGENTS IN THE THERAPY OF 

HEMOBLASTOSIS AND CARCINOMA AND COMPARISON 

OF THEIR EFFECT TO X-RAY THERAPY.] Zschr. 

Krebsforsch., 1952, 58: 500-503. Doses of 

50-250)* g of HBF 386~CActinomycin C) to 150 

patients with chiefly Hodgkin's disease 

gave similar results as treatment with 

nitrogen mustard, without toxic manifesta 

tions. Cases resistant to x-ray therapy 

were also resistant to therapy with HBF. 

53 

Schulte, G. and Lings, H. ERFAHRUNGEN MIT 

NEUEN ZYTOSTATISCHEN MITTELN BEI LEUKOSEN 

UND LYMPHOGRANULOMATOSEN UND DIE ABGRENZUNG 

IHRER WIRKUNGEN GEGEN RÃ–NTGENTHERAPIE. 

[EXPERIENCES WITH NEW CYTOSTATICS USED IN 

THE TREATMENT OF LEUCOSES AND LYMPHOGRANULO- 

MATOSES. COMPARISON OF THEIR EFFECTS TO 

X-RAY THERAPY.] Strahlentherapie, 1953, 

90: 301-306. Abstracted in: Excerpta med., 

Sect. 16, 1954, 2: No. 2251. This report 

is essentially tfie same as the one appearing 

in: Zschr. Krebsforsch., 1952, 58: 500-503.



ACTINOMYCIN C â€”¿ THERAPY 

(Continued) 

AGGLUTININS, 

PHYTO- 

54 

Schulte, G. RESULTADOS ULTERIORES EN LOS 

PACIENTES CON HNFOGRANULOMATOSIS TRATADOS 

CON SANAHICINA. (ACTINOMYCINA C 'BAYER'). 

[RESULTS OBTAINED IN CASES OF HODGKIN'S 

DISEASE TREATED WITH SANAMYCIN (BAYER'S 

ACTINOMYCIN C).] 

1954, 9: 144-145. 

Jornada med., B. Air., 

Abstracted in: Excerpta 

med., Sect. 16, 1955, 3: No. 167. 

55 

Schulte, G. WEITERE ERFAHRUNGEN MIT SANAMYCIN 

BEI DER BEHANDLUNG DER LYMPHOGRANULOMATOSE. 

[FURTHER EXPERIENCES WITH SANAMYCIN IN THE 

TREATMENT 

therapie, 

OF LYMPHOGRANULOMATOSIS.1 

1954, 94: 491-496. 

Strahlen 

ACTINOMYCIN D 

56 

Korst, D. R. and Meyer, 0. O. NEGATIVEEFFECT 

OF ACTINOMYCIND TREATMENTIN THREE CASES OF 

HODGKIN'S DISEASE. Antibiotic M., 1955, Â¡l: 

474-475. 2 reÃs. 

A-DENOPTERIN 

see GLUTAMIC ACID, 4-AMINO-9, N10-DI-METHYL- 

PTEROYL- 

ADENOSINEPHOSPHORIC 

ACIDS 

57 

Ambrus, C. M., Ambrus, J. L., Harrisson, J. W. E. 

and Cravetz, H. EFFECT OF ADENOSINE-5-PHOS 

PHORIC ACID, ADENOSINE-3-PHOSPHORIC ACID AND 

ADENOSINE TRIPHOSPHATE ON THE GROWTH OF EHRLICH 

CARCINOMA. Brit. J. Cancer, 1951, !5:311-316. 

22 refs. "Adenosine-3-phosphoric acid inhibits 

growth of subcutaneous Ehrlich carcinoma. Adenosine-5-phosphoric 

acid rather enhances tumor 

growth, whereas adenosine triphosphate has no 

effect. All three of the nucleotides brought 

about an increase in the death rate of animals 

inoculated intraperitoneally with Ehrlich car 

cinoma. The number of cancer cells, however, 

was smaller in the ascitic fluid of the nucleotide-treated 

mice than in the control animals." 

60 

Nungester, W. J. and Van Halsema, G. REACTION 

OF CERTAIN PHYTOAGGLUTININS WITH FLEXNER- 

JOBLING CARCINOMA CELLS OF THE RAT. Proc. 

Soc. Exp. Biol., N. Y., 1953, 83; 863-866. 

6 refs. Negative data. 

AHISTAN 

see PHENTIAZID, DIMETHYL-AMINO-ACETYL- 

61 

Akino, M. DIALYZABLE, GROWTH-INHIBITING SUB 

STANCE IN THE AUTOXIDATIONPRODUCTOF DOPA. 

Zool. Mag., Tokyo, 1953, 6.2: 44-47. 

ALANINE, 

see TYROSINE 

ALANINE 3,4-DIHYDROXY- 

3-(p-HYDROXYPHENYL)- 

See : 

4 

DL-ALANINE, 

62 

Biesele, J. J. and Jacquez, J. A. MITOTIC 

EFFECTS OF CERTAIN AMINOACID ANALOGSIN 

TISSUE CULTURE. Ann. N. York Acad. Sc., 

1954, 58: 1276-1287. 12 refs. 

ALAHINE, 

see TYROSINE, 

O-METHYL 

ADENOSINETRIPHOSPHATE 

DL-ALANINE, 

ALANINE, IODOACETYL PHENYL- 

/3-(p-FLUROPHENYL)- 

3-(p-METHCXYPHÂ£NYL)- 

(3-2-THIENYL- 

50 

Landau, J. V., Marsland, D. and Zimmerman, A. M. 

THE ENERGETICS OF CELL DIVISION: EFFECTS OF 

ADENOSINE TRIPHOSPHATE AND RELATED SUBSTANCES 

ON THE FURROWING CAPACITY OF MARINE EGGS 

(ARBACIA AND CHAETOPTERUS). 

1955, 45J 309-329. 17 refs. 

See: 

J. Cellul. Physiol. 

57 

ADENYLJC ACID 

see NUCLEOTIDES, 

PENTOSE 

AOIPIC ACID, 4-AMINOPTEROYL-AKINC- 

59 Kursanov, V. A. and Vodolazskafa, N. A. IZUCHENIE 

DEISTVIIA ANTAGONISTA FOLIEVOI KISLOTY 4-AMINO- 

PTEROÃ•L-AMINOADIPINOVOÃ• KISLOTY NA RAZVITIE 

PEREVIVAEMOGO LEÃ•KOZA U MYSHEÃ•. [THE EFFECT OF 

THE FOLIC ACID ANTAGONIST, 4-AMINOPTEROYL-AMINO- 

ADIPIC ACID, ON THE DEVELOPMENT OF TRANSPLANTED 

MOUSE LEUKEMIA.] Vopr. onkol., 1955, 1: No. 4, 

59-64. 14 refs. The compound AD inhiEjted the 

subcutaneously transplanted tumor; lowered the 

leucocyte count and decreased the size of the 

spleen. AD is 20 times less toxic than aminopterin. 

63 

Jacquez, J. A., Stock, C. C. and Barclay, R. K. 

EFFECT OF (5 -2-THIENYL-DL-ALANINE ON THE 

GROWTHOF SARCOMAT241 IN C57 BLACKMICE. 

Cancer, 1953, 6: 828-836. 18 refs. 

ALBUMINS 

64 Leupold, E., Huhn, A. and Sehneppenheim, P. 

ABBAU VON WALKER-KARZINOMEN UND SPONTANEN 

MÃ„USE-KARZINOMEN DURCH BEEINFLUSSUNG DES 

ZELL- UND GEWEBSSTOFFWECHSELS. [EFFECT OF 

CELLULAR AND TISSUE METABOLISM ON REGRES 

SION OF WALKER CARCINOMA AND SPONTANEOUS 

CARCINOMA IN MICE.] Arch. Geschwulstforsch., 

1955, 8: 36-52. 6 refs. The administration 

of metabolic products alone caused regres 

sion of the Walker carcinoma. Additional 

intravenous injections of D-glucose produced 

better results and an even greater number of 

animals recovered when cholesterol and leci 

thin were added to their diet. 

ALDEHYDES - EFFECT ON TUMOR GROWTH 

See: 

708 709 710 716



ALDEHYDES â€”¿ THERAPY 

65 

SolomidÃ¨s, J. and Ronsin, J. CHIMIOTHÃ‰RAPIE 

DU CANCER CONSIDÃ‰RÃ‰COMME MALADIE Ã€VIRUS. 

I. LES ALDÃ‰HYDES. [CHEMOTHERAPY OF CANCER 

CONSIDERED AS A VIRUS DISEASE. I. ALDE 

HYDES.] 56p. Paris, le FranÃ§ois, 1952. 

(Monographies d'olÃ©othÃ©rapieexpÃ©rime *.ale, 

1952, V. 1.) 16 rets. 

ALKALINE SUBSTANCES, BROMINATED 

BaÃ±uelos Garcia, M. SOBRE EL EMPLEO DE LOS 

COMPUESTOS BROMURADOS ALCALINOS EN EL TRATA 

MIENTO DE LOS CANCEROS DE UTERO Y MAMA. 

[ON THE USE OF BROMINATED ALKALINE SUB 

STANCES IN THE TREATMENT OF UTERINE AND 

MAMMARY GLAND CANCER.] Gao. mÃ©d. espaÃ±., 

1947, 21: 488-490. Also in: Tokogin, 

pract.TTIadr., 1948, 7: 173-179. 

ALKALOIDS 

J7 

Â»LettrÃ©,H. and Albrecht, M. WEITERE UNTER 

SUCHUNGEN ÃœBER EINE MITOSEGIFTWIRKUNG VON 

ALKALOIDEN. [FURTHER STUDY OF MITOTIC 

POISONOUS ACTION OF ALKALOIDS.] Zschr. 

physiol. Chem., 1951, 287: 58-65. 

67Schmitz, H. ZUR BEEINFLUSSUNG DES ZELLSTOFF 

WECHSELS DURCH ALKALOIDE. II. EINWIRKUNG 

VON ALKALOIDEN MIT STILBYLAMINGRUPPE AUF 

ZELLEN DES MAUSE-ASCITESTUMORS. [THE EFFECT 

OF ALKALOIDS ON CELL METABOLISM. II. THE 

EFFECT OF ALKALOIDS WITH STILBYLAMINE GROUPS 

ON THE CELLS OF MOUSE-ASCITES TUMOR.] Zschr. 

Krebsforsch., 1951, 57: 405-422. 22 refs. 

Abstracted in: Excerpta mod., Sect. 5, 1952, 

5: No. 1130. 

68 Schnitz, H. ZUR BEEINFLUSSUNG DES ZELLSTOFF 

WECHSELS DURCH ALKALOIDE. III. EINWIRKUNG 

VON ALKALOIDEN OHNE BEZIEHUNG ZUR STILBYL 

AMINGRUPPE AUF ZELLEN DES MÃ„USEASCITESTUMORS. 

[THE EFFECT OF ALKALOIDS ON CELL METABOLISM. 

III. THE EFFECT OF ALKALOIDS WITHOUT RELA 

TION TO THE STILBYLAMINE GROUP ON MOUSE AS- 

CITES TUMOR CELLS.] Zschr. Krebsforsch., 

1951, 57: 463-480. 39 refs. Abstracted in: 

Excerpta med., Sect. 5, 1952, 5: No. 1553. 

The effect of 56 alkaloids on Tumor respira 

tion is tested. It was found that compounds 

inducing fatty changes in cell cytoplasm 

almost always inhibit cell respiration. 

ALKANES, 

See 

2857 

DIPHENYL- 

70 

Flinn, L. B., Minnick, E. and Gay, D. M. 

ALLOXAN IN THE TREATMENT OF A CASE OF ISLET 

CELL CARCINOMA OF THE PANCREAS WITH LIVER 

METASTASES. Ann. Int. Med., 1947, 26: 

936-945. 10 refs. Alloxan did not pro 

duce any observable clinical effect. An 

autopsy examination revealed slight evi 

dence of tumor cell damage in the liver 

mÃ©tastases as compared with biopsy findings 

taken before alloxan therapy was started. 

ALLOXANIC ACID 

See: 

140 

ALUMINUM CHLORIDE 

See 

295 

A-METHOPTERIN 

AMICETIN 

Burchenal, J. H., Yuceoglu, M., _., â€”¿â€žâ€ž, 

Dagg, _. M. K. and 

Stock, C. C. LEUKEMIA. VI. EFFECT OF AMICETIN 

ON TRANSPLANTED MOUSE LEUKEMIA. Proc. Soc. 

Exp. Biol., N. Y., 1954, 86: 891-893. 9 refs. 

see GLUTAMIC ACID, 4-AMINO-N10-METHYLPTEROYL- 

AMIDINES, DI- 

72 Kopac, M. J. THE ACTION OF DIAMIDINES AND RE 

LATED COMPOUNDS ON NUCLEOPROTEINS. Cancer 

Res., 1947, 7: 44-46. 

AMINE, HYDROXY- 

73Schmitz, H. ÃœBER DEN NACHWEIS VON DEHYDRASEN 

AM ASCITES TUMOR DER MAUS MIT DER THUNBERG- 

METHODE. [DEMONSTRATION LJhMUrio J tl.'\ l l UÂ« \jr OF DEHYDROGENASES i^rinii^nvju&iirnjuu IN J 

m E. l IlVJUiJ â€¢¿ .!,_ _r_I."_ Â«â€¢Â» Â«n rrrrwilWTttmS' l O UL'TIIi'^n l 

..â€žâ€ž MICK â€ž¿â€ž~â€ž.-S 

ASCITt. TUMOR WITH THUNBERG'S METHOD.] 

Zschr. Krebsforsch., 1950, 56: 596-600. 6 refs. 

Abstracted in: Chem. Abstr., 1950, 44: 8502e. 

See 

3133 

ALLOXAN 

69 Bottger, H., RÃmer, K. and Seitz, R. ALLOXAN- 

WIRKUNGEN BEI EINEM INSELZELLTUMOR. [THE 

EFFECT OF ALLOXAN ON ISLET CELL TUMOR.] 

Klin. Wschr., 1952, 30: 507-510. 21 reÃs. 

Alloxan in a total amount of 43.5 g over a 

period of 2 months was administered to a 

female patient. A post mortem examination 

disclosed a small alveolar adenoma of the 

pancreas. Pathological tests showed that 

the ft -cells were distroyed, but that the 

ot -cells showed proliferation. Infiltra 

tion of eosinophils in the heart muscle 

tissue also was observed. 

AMINES, AROMATIC DI- 

\opac, H. J. SOME CELLULAR AND SURFACE CHEMICAL 

ASPECTS OF TUMOR CHEMOTHERAPY. In: APPROACHES 

TO TUMOR CHEMOTHERAPY. Wash., Am. Ass. Advance. 

Sc., 1947, p. 27-57. Bibliography: p. 54-57. 

AMINC ACID ANALOGS 

75 rreenbere D M and Schulman, M. P. APPLICATION 

OF "METABOLITE ANTAGONISM" TO CANCER RESEARCH. 

Science 1947, 106: 271-272. 6 refs. Abstracted 

in- Biol. Abstâ€” Bait., 1948, 22: No. 3702-, 

Chem. Abstr., 1947, 41: 7509g.



AMINO ACID ANALOGS (continued) 

AMMONIUM 

COMPOUNDS 

76 

AMINO 

acquez, J. A. and llottram, F. TISSUE CULTURE 

SCREENING OF A1IINO ACID ANALOGS FOR SELECTIVE 

DAMAGE TO MOUSE SARCOMA CELLS. Cancer Res., 

1953 13: 605-609. 20 refs. Abstracted in: 

Excerpta med., Sect. 5, 1954, 7: No. 880; 

Chem. Abstr., 1953, 47: 11484c. 

ACIDS 

77 

Zbarskii, I. B. VLIÃ•ANIE NEKOT.OKYKHAMINOKISLOT 

NA ROST PEREVIVNYKH OPUKHOLEI MYSHEI. [THE 

INFLUENCE OF SOME AMINO ACIDS ON THE GROWTH 

OF TRANSPLANTED MOUSE TUMORS.) Vopr. onkol., 

1955, No. 1, 41-45. 19 refs. Ten injections 

of L-argenine, L-lysine, L-histidine and 

glutamic acid given immediately following 

Ehrlich tumor transplantation caused inhibition 

of the transplanted tumor; injections admin 

istered when the transplanted tumor had taken 

(12 days after transplantation) did not in 

hibit tumor growth. 

AMINO-AN-FOL 

see ASPARTIC ACID, 4-AMINO-PTEROYL- 

AMNOPTERIN 

see GLUTAMIC ACID, 4-AMNOPTEROYL - 

AMKARGEN 

Â»Kuzmina, N. A. OPYT LECHENIÃŽÃ€AMMARGENOM RAKA 

SHEÃ•KI MATKI. [TREATMENT OF CERVICAL CANCER 

WITH AMMARGEN.] Tr. KuÃ¯byshev, med. inst., 

1948, 1: 119-128. Abstracted in: Sov. raed, 

rÃ©f. ob~ozr., onkol., 1949, No. 2, 43. 

"Cervical cancer in 30 patients was treated 

with ammargen in a 1:20000 solution. Ammargen 

treatment resulted in an increase of 

body temperature; locally, it affected the 

regeneration of the epithelium and connective 

tissue and the lymphatic system. While 

ammargen did not cause complete tumor re 

gression, it inhibited surface ulcÃ©ration 

and bleeding. Ammargen possesses bacteri 

cidal and desodorant properties; it should 

be used as a preoperative measure or in 

patients with incurable cervical cancers." 

AMMONIUM BROMIDE, TETRAETHYL- 

79 BenkÂ», S. A TETRAAETHYLAMMONIUMBROMIDHAEMATO- 

LOGIAI HATÃ•SA; ELÃ–ZETES KOZLEMÃ‰NY. [HEMATO- 

LOGICAL EFFECT OF TETRAETHYLAMMONIUM-BROMIDE; 

PRELIMINARY NOTE.] Orv. hetil., 1953, 94: 

16-17. 2 refs. Experimental and clinical 

results are reported. TEBA reduces the leu 

cocyte count in chronic myeloid leukemia and 

reduces the erythrocyte count in erythraemia. 

AMMONIUM 

See: 

321 

CHLORIDE 

80 

LettrÃ©, H. ZUR WIRKUNG QUARTÃ„RERAMMONIUM- 

VERBINDUNGEN AUF DIE ZELLE DES MXUSE-ASCITES- 

TUMORS. [THE EFFECT OF QUATERNARY AMMONIUM 

COMPOUNDS ON THE CELLS OF THE MICE-ASCITES- 

TUMOR.] Naturwissenschaften, 1948, 35: 

317-318. 6 refs. Abstracted in: BioT. Abstr., 

Bait., 1951, 25: No. 10756. 

AMYTAL 

SODIUM 

81 â€ž¿ 

Podzei, L. K. 

DLITEL'NOGO 

and Vinggradova, V. D. VLIIANIE 

WEDENIÃ•A SNOTVORNYKH PREPARATOV 

NA ROST I METASTAZIROVANIE KROLICH'EI OPUKHOLI 

BROUN-PIRSA. [THE EFFECT OF PROLONGED ADMINIS 

TRATION OF ANESTHETIC PREPARATIONS UPON THE 

GROWTH AND METASTASES OF BROWN-PEARCE TUMORS 

IN RABBITS.] Vopr. onkol., 1955, 1^: No. 2, 

28-32. In several series of tests, 8-10 

rabbits with Brown-Pearce tumors were treated 

with amitalnatrium, hexanol, and chloral hy 

drate. While there was damage to the central 

nervous system, the growth of tumors was not 

inhibited. 

ANCYLOSTCMA INFECTION â€”¿THERAPY 

82 

Brumpt, L. C. and Gujar, B. J. THE TREATMENT 

OF POLYCYTHEMIA BY ARTIFICIAL INFECTION WITH 

ANCYLOSTOMA DUODENALE. Ind. M. Gaz., 1948, 

8Â£: 166-169. 7 refs. 

83 Nagaty, H. F. and Zanaty, A. F. POLYCYTHEMIA 

VERA; RECORD OF CASE TREATED WITH ANCYLOSTOMA 

INFECTION. Tr. R. Soc. Trop. M. Hyg., Lond., 

1949, 42: 493-499. 1 rÃ©f. 

ANESTHETICS 

For a particularanestheticsee under name 

84 Treuherz, Â». DA POSSIVEL EFICIENCIA ANTINEO- 

PLASICA DE VAPOR SUPERAQUECIDO (V.S.) DE 

Ã‰TER, BALSOFORME E CHLOROFORMIO. [POSSIBLE 

ANTINEOPLASTIC EFFICACY OF SUPERHEATED VAPOR 

OF ETHER, BALSOFORME AND CHLOROFORM.] Arq. 

Inst. biol., S. Paulo, 1950-1951, 20: 

147 163. 4 refs. English summary. Over 

heated vapors of ether, balsoform and chloro 

form gave temporary but noteworthy improve 

ment in 50 patients with cancer. Tumors in 

animals treated with the vapors were smaller, 

sometimes very much so, than in untreated 

animals. Period of survival was decidedly 

longer in treated animalsÂ« 

85 

Treuherz, W. UEBER DIE WIRKUNG VON INHALA 

TIONEN UEBERHITZTER DAEMPFE VERSCHIEDENER 

ANAESTHETICA (H.A.) BEI 84 INOPERABLEN 

KREBSKRANKEN. [THE EFFECT OF THE INHALA 

TION OF OVERHEATED VAPORS OF VARIOUS ANE 

STHETICS (H.E.) IN 84 CASES OF INOPERABLE 

CANCER.] Acta UniÃ³ internat, cancr., 

Louvain, 1955, 11: 203-219. 10 refs. The 

anti-neoplastic~action of heated vapors of 

various anesthetics(ether, chloroform, trichlorethylene 

and chloroethyl) in human 

cancer was proven by clinical observations 

and by hystopathological examinations. 

ANILINE 

86 Abeatici, S. ANTISTAMINICI E ADENOCARCINO- 

MA DEL TOPO; RICERCHE SPERIMENTALI. [ANTI- 

HISTAMINS AND ADENOCARCINOMA OF THE RAT; EX 

PERIMENTAL STUDIES.] Neoplasie, Tor., 1952, 

5: 126-135. 14 refs. Subcutaneous injec 

tions of 1 eg. of dimethylaminoethylbenzylaniline 

hydrochloride inhibited the growth 

of transplanted Ehrlich adenocarcinoma in 

white rats, and prevented decrease in body 

weight.



A-NINOPTERIN 

see GLUTAMC 

ACID, 4-AMINO-9-METHYLPTEROYL- 

EFFECT 

ON TUMOR GROWTH IN PLANTS 

ANTIBIOTICS 

For a particular antibiotic see under name 

87 Klfueva,N. G. and Roskin, G. I. PROBLEMA 

PROTIVORAKOVYKHANTIBIOTIKOV. [ANTI- 

TUMORALANTIBIOTICS.] Usp. sovr. biol., 

1956, 41: No. 1, 55-73. Approx. 100 refs. 

EFFECT 


Ambrus, J. L., Ambrus, C. M., Sideri, C. N. and 

Harrisson, J. W. E. EFFECT OF BROAD SPECTRUM 

ANTIBIOTICS ON TUMOR INDUCING VIRUSES. Anti 

biotics, 1953, 3: 16-22. 14 refs. Abstracted 

in: Excerpta meo"., Sect. 16, 1954, No. 125. 

89 

Castelli, V. and Gaggini, V. ANTIBIOTIQUES POUR 

CELLULES CARCINOMATEUSES? [ANTIBIOTICS FOR 

CARCINOMA CELLS?] Schweiz, med. Wschr., 1948, 

78: 424-428. 20 refs. Abstracted in: Excerpta 

med., Sect. 5, 1948, .1:No. 1019. 

90 

91 

92 

Noîaes!" 

1Â¿:BÃ•Â°Ã-~ÃÂ¿str-rÃBaÃ•t.? Ã®lfl; 28: 

Drummond, J. MALIGNANT DISEASE- A NEW THEORY 

' 

1949, 23: 498-503 

Manli. P. ACTION D'ANTIBIOTIQUES SUR DES TUMEURS 

VEGETALES. [EFFECT OF ANTIBIOTICS ON PLANT 

TUMORS.] Ann. Soc. se. med. natur. Bruxelles, 

1953, 6: 150-155. 19 refs. 

See: 

1335 

METABOLISM (INCLUDING EFFECTS ON METABOLIC 

PROCESSES) 

99 

Â«Romanyuk, N. M. eTHE INFLUENCE OF THE ANTIBIO 

TICS OF GARLIC ON THE ACTIVITY OF PROTEOLYTIC 

ENZYMES OF MALIGNANT TUMORS OF HUMANS AND EX 

PERIMENTAL ANIMALSj Ukrain. 

1952, 24: 53-60. Abstracted 

biokhim. 

in: Chem. 

J., 

Abstr., 

1954, W: 6007e. 

THERAPY 

100 

JimÃ©nez de Asua. F. ANTIBIÃ“TICOSCOMOANTI 

TUMORALES. [ANTIBIOTICS AS ANTI-TUMORDRUGS.] 

Med. panamer., 1954, 2: 95-100. 31 refs. 

See: 

1145 1543 

ANTIMONIALE 

101 

Garb. J. LONG REMISSION IN MYCOSIS FUNGOIDES 

TREATED WITH ANTIMONIALE. A.M.A. Derm. Syph., 

Chic., 1950, 62: 757-759. 

102 Garb J. MYCOSIS FUNGOIDES, FUNGOID STAGE, 

TREATED WITH ANTIMONY PREPARATIONS. Arch. 

Derm. Syph., Chic., 1949, 60: 811-814. 

93 

Gauze, G. F. O VLIÃ•ANII ANTIBIOTIKOV NA ROST 

ZLOKACHESTVENNYKH OPUKHOLEI. [THE EFFECT OF 

ANTIBIOTICS ON THE GROWTH OF Â«ALIGNANT TUMORS 

Vest Akad. med. nauk SSSR., 1954, No. 4, 

â€¢¿o Â«o Actinomvcin C, azaserine, leuteomycin 

Ã•JS ' sarcomTcin aÂ°d trychomycin are des 

cribed. Each of the antibiotics was tested 

experimentally in mouse Walker sarcoma, and 

clinically in human lymphogranulomatosis 

Azaserine showed the best and sarcomycin the 

least anti-tumor effect. 

94 

95 

96 

Stock, C. C., Sugiura, K. and Rhoads, C. P. 

THE INFLUENCE OF ANTIBIOTIC PREPARATIONS 

ON THE VIABILITY AND GROWTH OF SARCOMA 

MELANOMA, AND CARCINOMA IN MICE. Acta UniÃ³ 

Internat, cancr., Louvain, 1949, 6: 550- 

554. 8 refs. 

97 

Yamamoto, T. and Yamaoka, S. A STUDY OF THE 

SCREENING METHOD OF ANTI-TUMOR SUBSTANCES 

PRODUCED BY MICROORGANISMS. J. Antibiotics 

Ser. A, Tokyo, 1954, 7:7-9. 

103 Garb, J. MYCOSIS FUNGOIDES (GRANULOMA FUNGOIDES) 

TUMOR STAGE, RESPONDING RAPIDLY TO ANTIMONY 

PREPARATIONS; PRELIMINARY REPORT. J. Invest. 

Derm., 1948, 10: 43-49. 2 refs. 

Hauer, A. A CURA SISTEMÃ€TICA DO CANCER PELA 

POLIMETALOTERAPIA E A DUALIDADE DA SUA 

FORMULA. [SYSTEMATIC TREATMENT OF CANCER 

WITN METAL THERAPY AND THE DUALITY OF THIS 

METHOD.] Brasil med., 1948, 62: 257-261. 

105 

Rubinstein, M. A. CHEMOTHERAPY OF MULTIPLE 

MYELOMA; 

REPORT. 

THE USE OF ANTIMONY; A PRELIMINARY 

Blood, N. Y., 1947. 2: 555-563. 

The case histories of 7 patients with multi 

ple myeloma treated with antimony in doses 

of 0.3 gm are reported. The possible influence 

of the compounds on the myeloma cells is shown 

by increased sensitivity to roentgenotherapy. 

The effects of antimony are similar to those of 

stilbamidine. 

1O6 

Rubinstein, M. A. USE OF ANTIMONY IN MULTIPLE 

MYELOMA. Blood, Bait., 1949, 4: 1068-1072. 

3 refs. 

107 Shircore, J. O. NOTES ON TWO CASES OF TUMOUR 

OF THE ILLIAC FOSSA TREATED WITH ANTIMONY 

ARSANILATE. 

190-191. 

East Afr. M. J., 1951, 28: 

See: 

121 1317



APOST AXINE 

see BACTERIA 

ARGINASE â€”¿ EFFECT 


108 

Greenberg, D. M. and Sassenrath, E. N. LACK 

OF EFFECT OF HIGH POTENCY ARGINASE ON TUMOUR 

GROWTH. Cancer Res., 1953, 1J5: 709-715. 

25 refs. 

109 

Irons, W. G. and Boyd, E. F. ARGINASEAS IN 

[SIC] ANTI-CARCINOGENICAGENT IN MICE AND 

HUMANBEINGS. Arizona M., 1952, 9: No. 3, 

39-45. 72 refs. Abstracted in- Excerpta 

med., Sect. 5, 1952, 5: No. 3151. 

110 

Neukomm, 

ACTION 

S., Thompson. 

DE L'ARGINASE 

C. B. and Boissonnaz, A. 

PURE SUR LA CROISSANCE 

DU CANCER GREFFÃ‰ DE LA SOURIS. [ACTION OF 

PURE ARGINASE ON THE GROWTH OF MOUSE CANCER 

GRAFTS.] Experientia, Basel, 1949, 5: 239- 

241. 8 refs. 

Ill 

Simon-Reuss, I. AHGINASE, AN ANTIMITOTIC 

AGENT IN TISSUE CULTURE. Biochim. biophys 

acta, Amst., 1953, 11: 396-402. 12 refs 

fibroblast and of Jensen sarcoma cultures, 

caused a strong mitotic inhibition..." 

112 

Vrat, V. EFFECTS OF ADRENOCORTICOTROPIC HOR 

MONE (ACTH), CORTISONE, AND ARGINASE ON GROWTH 

OF TRANSPLANTED MAMMARY ADENOCARCINOMA IN CsH 

MICE. 

60-70. 

Permanente 

40 refs. 

Found. M. Bull., 1951, 9: 

Abstracted in: Chem. Abstr., 

1952, 46: 7658h. 

113 

Vrat, V. INHIBITORY EFFECTS OF ARGINASE ON 

MAMMARY ADENOCARCINOMA TRANSPLANTS IN STRAIN 

A MICE. Permanente 

9: 56-59. 3 refs. 

Found. M. Bull., 1951, 


Abstr., 1952, 46: 7658g. When Strain A mice 

with mammary adcnocarcinoma transplants were 

administered arginase, the transplants almost 

completely disappeared while a similar group 

of controls died from their tumors. 

114 Vrat, V. A PRELIMINARY REPORT ON THE HISTOLO- 

GICAL AND HISTOCYTOCHEMICAL CHANGES IN MAM 

MARY CARCINOMA IN MICE AFTER INTRAPERITONEAL 

INJECTIONS OF ARGINASE. Permanente 

M. Bull., 1951, 9: 49-55. 36 refs. 

Found. 

When 

mice with spontaneous mammary carcinomas re 

ceived intraperitoneal injections of arginase, 

the tumors were reduced in size, became firm 

and encapsulated and contained no arginine 

but their histology was considerably altered. 

None of the animals died from the injections 

nor iron their tumors after treatment. 

115 

Â«Wiswell, 0. B. EFFECTS OF INTRAPERITONEALLY 

INJECTED ARGINASE ON GROWTH OF MAMMARY CARCI 

NOMA IMPLANTS 

Biol., N. Y., 

IN THE MOUSE. Proc. Soc. Exp. 

1951, 76: 588-589. Abstracted 

in: Excerpta med., Sect. 5, 1952, 5: No. 1947. 

ARGININE 

116 

Levy, H. M., Montanez, G., Feaver, E. R., 

Murphy, E. A. and Dunn, M. S. EFFECT OF 

ARGININE ON TUMOR GROWTH IN RATS. Cancer 

Res., 1954, 14: 198-200. 18 refs. 

117 

Passera, G. ARGININA E NEOPLASIE DA INNESTO. 

[ARGININE AND TRANSPLANTED NEOPLASMS.] 

Neoplasie ti aliment., 1953, 6: 281-288. 

30 refs. Arginine (CgHl402N4) in doses of 

50 mg injected subcutaneously to 30 male 

albino rats inhibited the growth of Ehrlich 

adenocarcinoma, prevented decrease in body 

weight and increased neoplastic ulcÃ©ration. 

AHSENICALS - EFFECT ON MALIGNANT GROWTH 

118 BeÂ£Ã•Â¿ L>V> ACTION OF BAL ON THE TUMOR-DAMAGING 

POTENCY OF CERTAIN TRIVALENT ARSENIC COMPOUNDS 

J. Nat. Cancer Inst., 1952, 13: 619-625 

8 refs. 

119 

Engle, R. L., Jr., Reznlkoff, p., Lott W A 

and Yale, H. L. COMPARATIVE EFFECTIVENESS' 

OF FIVE NEWLY SYNTHESIZED ARSENICAL COM 

POUNDS IN TREATMENT OF LEUKEMIA IN MICE 

Proc. Soc. Exp. Biol., N. Y., 1952 80-' 

4??7492;, VefS- None of the drugs "were sig 

nificantly better than potassium arsenite 

120 

Leiter, J., Downing, V., Hartwell, J. L. and 

Shear, M. J. DAMAGE INDUCED IN SARCOMA 37 

WITH CHEMICAL AGENTS. II. TRIVALENT AND 

PENTAVALENT ARSENICALE. J. Nat. Cancer Inst. 

1952, 13: 365-378. 10 refs. 

See: 

107 325 922 


PROCESSES) 

121 Leiter, J., Paradis, A. D. and Waravdekar V S 

ENZYME CHANGES INDUCED IN NORMAL AND MALIG 

NANT TISSUES WITH CHEMICAL AGENTS. II EF 

FECT OF VARIOUS COMPOUNDS ON THE CYTOCHROJÃ•E 

OXIDASE ACTIVITY OF TRANSPLANTED TUMORS. J 

Nat. Cancer Inst., 1953, 14: 177-188. 11 refs 

MODE OF ACTION 

122 

Loveless, A. and RÃ©veil, S. NEW EVIDENCE ON 

THE MODE OF ACTION OF 'MITOTIC POISONS.' 

Nature, Lond., 1949, 164: 938-944. 53 refs. 

PHARMACOLOGICAL AND PHYSIOLOGICAL 

EFFECTS 

123 Nishimura, M. PHARMACOLOGICAL RESEARCH ON THE 

MORPHOLOGICAL CHANGES OF LEUCOCYTES IN CUL 

TURE. Folia pharm., Jap., 1947, 43: 1-9. 

Abstracted in: Excerpta med., SecÃ¯T 2, 1949, 

2: No. 6594. 

THERAPY 

124 

Heusch, K. THERAPIEVERSUCHE MIT ARSEN BEIM 

INOPERABLEN BLASENKREBS. [TREATMENT OF 

INOPERABLE CANCER OF THE BLADDER WITH ARSENIC]. 

Zschr. Urol., 1952, Sonderhft., 298-302. 4 

refs. 

125 

Piney, A. THE PRESENT POSITION IN THE TREAT 

MENT OF CHRONIC MYELOID LEUKEMIA. Blood, 

Bait., 1948, 3: 885-891. 7 refs. A short 

review. Also~in: Sympos. femat., N. Y., 

1949, 572-578. 

126 

Moeschlin, S. DIE THERAPIE DER LEUKÃ„MIEN MIT 

RONTGEN, ARSEN UND URETHAN. [TREATMENT OF 

THE LEUKEMIAS WITH X-RAYS, ARSENIC AND URE- 

THANE.j Helvet. med. acta, 1948, 15: 107- 

128. Approx. 20 refs.



10 

ARSENICALE â€”¿ THERAPY 

(Continued) 

127 Beck, L. V. LETHAL AND TUMOR-DAMAGING EFFECTS 

OF CERTAIN TRIVALENT ARSENICALS, AS MODIFIED 

BY 2,3-DIMERCAPTOPROPANOL (BAL), AND BY ADRE 

NAL EXTRACTS. Cancer Res., 1950, 10: 202. 

An abstract. 

128 Beck, L. V., Perrault, A. and Gillesple, J. 

RELATIVE TOXICITY TO NORMAL AND TUMOR BEARING 

MICE OF CERTAIN AROMATIC TRIVALENT ARSENICALS 

WHICH INDUCE HISTOLOGICAL DAMAGE IN SARCOMA 

37. Cancer Res., 1949, 9: 626. An abstract. 

ARSENITE, POTASSIUM - EFFECT ON MALIGNANT 

GROWTH 

129 Geisse, N. C. and Kirschbaum, A. TRANSPLANTED 

MOUSE LEUKEMIA AS A TEST OBJECT FOR THE 

EVALUATION OF CHEMOTHERAPEUTIC AGENTS. 

Cancer Res., 1950, 10: 108-112. Abstracted 


If treatment is begun a few days after trans 

fer of mouse myeloid leukemia, potassium 

arsenite may completely inhibit and urethane 

may delay the development of the leukemia but 

if given after the host is leukemic no pro 

tection is afforded. It would seem that 

these findings may apply to other agents 

such as the folie acid antagonists. 

130 Kirschbaum, A., Judd, T., Lu, C. S., Engstrom, 

R. M. and Mixer, H. EFFECT OF URETHANE, 

X-RAYS, POTASSIUM ARSENITE, BENZOL, ON SUR 

VIVAL TIME IN TRANSPLANTED MOUSE LEUKEMIA. 

Proc. Soc. Exp. Biol., N. Y., 1948, 68: 377- 

380. tab. 11 refs. Abstracted in:~E~xcerpta 

med., Sect. 5, 1949, 2: No. 1183; Biol. Abstr., 

Bait., 1949, 23: No. 3984. 

131 Pollak, M J , Kirschbaum, A. and Wagner, J. 

REFRACTORINESS IN THE THERAPY OF TRANSPLANTED 

MOUSE LEUKEMIA. Cancer Res., 1953, 13: 39-44. 

29 refs. "These results suggest thaF~2 se 

parate types of resistance of transplanted 

leukaemias to drugs may be induced - one a 

cellular resistance residing in the leukaemic 

cell, the other a resistance generated by 

the host." 

Sacchetti, C. and Bianchirti, E. ATTIVITÃ€' BIO- 

LOGICHE DEL MIDOLLO OSSEO NELLA LEUCEMIA MIE- 

LOIDE CRONICA. I. PROLIFERAZIONE ED EVOLU 

ZIONE DEI GRANULOBLASTI. [BIOLOGICAL ACTION 

OF BONE MARROW IN CHRONIC MYELOID LEUKEMIA. 

I. PROLIFERATION AND EVOLUTION OF GRANULO 

BLASTS.] Boll. Soc. ital. biol. sper., 

1953, 29: 1285-1287. 5 refs. 

EFFECT ON NORMAL GROWTH 

THERAPY 

134 

Marlow, A. A. and Bartlett, G. R. SURVIVAL 

FOR TWENTY-NINE YEARS IN CHRONIC LYMPHOCYTIC 

LEUKEMIA. J. Am. M. Ass., 1953, 152: 1033- 

1035. 

135 

Spurr, C. L., Smith, T. R. and Jacobson, L. O. 

CHEMOTHERAPY IN HUMAN LYMPHOMAS, LEUKEMIAS, 

AND ALLIED DISORDERS OF THE HEMOPOIETIC SYS 

TEM. Radiology, 1948, 50: 387-394. 17 refs. 

Spanish summary: p. 393^794. 

136 Tropeano, L. L'ARSENITO DI POTASSIO, LIQUORE 

ARSENICALE DI FOWLER, NELLA TERAPIA DELLA 

MIELOSI LEUCEMICA CRONICA. [POTASSIUM 

ARSENITE, FOWLER'S ARSENIC SOLUTION, IN THE 

TREATMENT OF CHRONIC MYELOID LEUKEMIAS.] 

Progr. med., Nap., 1949, 5: 353-355. 8 refs. 

See 

1562 1750 2045 

ASCORBIC ACID â€”¿ EFFECT 

ON MALIGNANT GROWTH 

137 Levey, S. EFFECT OF ASCORBIC ACID, D-ISOASCOR- 

BIC ACID AND GLUCOASCORBIC ACID ON COBALT 

POLYCYTHEMIA IN RAT AND RABBIT. Am. J. Physiol. 

1949, 158: 315-318. 

Â«KhaneniÃ F. , S. DEÃ•STVIEL- AND D- ASKORBINOVOÃ• 

KISLOTY NA ROST SARKOMY KROKERA. [THE EFFECT 

OF L- AND D- ASCORBIC ACID ON THE GROWTH OF 

CROCKER SARCOMA.] BÃŒÃ¹ll.nauch. issi. lab. 

eksp. khimioter. Min. zdravookhr. SSSR, 1949, 

11: No. 1, 61-65. Abstracted in: Sov. Med. 

Ref. Oboz., Sect. OnkologiÃŸ, vyp. 3, 1950. 

D-ascorbic acid greatly inhibited the growth 

of Crocker sarcoma, while 1-ascorbic acid 

promoted tumor growth. 

See 

1777 3668 

â€”¿THERAPY 

139 

Meyer, B. A. and Orgel, I. S. THE CANCER PATIENT: 

A NEW CHEMOTHERAPY IN ADVANCED CASES. 85 p. 

London, Churchill. 1950. 

See 

1809 3670 

362 2147 2148 

_ METABOLISM (INCLUDING EFFECTS ON METABOLIC 

- MODE OF ACTION 

133 

Florijn. 

THE ACTION OF ARSENITE AND 

Abstracted in: Cnem. 

No. 621Ã•. 

, 46. 

ASCORBIC ACID, DEHYDRO- 

Morel, A. and Josserand, A. LA DESINFILTRATION 

PALLIATIVE DES CANCERS PAR DIVERS SELS COM 

PLEXES FERRICO-SODIQUES. INDICATIONS RES 

PECTIVES DES VOIES BUCCALE ET PARENTÃ‰RALE. 

[PALLIATIVE DISINFILTRATION OF CANCERS BY 

MEANS OF CERTAIN COMPLEX FERRIC SODIUM SALTS. 

INDICATIONS OF ORAL AND PARENTERAL ADMIN 

ISTRATION RESPECTIVELY.] J. med. Lyon, 1948, 


Sect. 2, 1948, 1: No. 6741. 

ASCORBIC ACID, D-ISO- 

See: 

137



11 

ASPARTIC ACID, 4-AMINOPTEROYL-, â€”¿EFFECT 

ON NORMAL GROWTH 

See 

1049 2874 


4 Little, P. A.. Sampatb, A. and Subbarow, Y. 

THE USE OF ANTAGONISTS OF PTEROYLGLUTAMIC 

ACID IN CONTROLLING ROUS CHICKEN SARCOMA. 

J. Laborat. Clin. M., 1948, 33: 1144-1149. 

11 reÃs. 

1054 1381 1391 1649 

-THERAPY 

142 

Bell, E. C. and Davis, P. L. THE EFFECT 

OF A FOLIC ACID ANTAGONIST, 4-AMINO- 

PTEROYL-ASPARTIC ACID, IN THE TREATMENT OF 

POLTCTTHEMIA 

Path., 1950, 

RUBRA VERA. 

20: 839-841. 

An. J. Clin. 

5 refs. 

143 

Mendonca. J. M. de RECENTES AQUISIÃ‡OESNO THA- 

TAMENTO DAS LEUCEMIAS AGUDAS. [RECENT ADVANCES 

IN THE TREATMENT OF ACUTE LEUCEMIAS.] Arq. 

clin., Bio, 1951, 12: 162-177. 19 refs. 

144 

THERAPY OF POLYCYTHEMIA. 

9:108-109. 

See 

566 

1573 

1646 

-â€”TOHCITY 

1035 

1583 

1648 

1286 

1639 

NUTRIT. REV., 1951, 

1331 

1642 

1504 

1643 

145 

Kraus, S. D., Weintraub, S. and Wright, L. T. 

VARIATIONS IN TOLERANCEOF MICE TO AMINO-AN- 

FOL (D-Ali INOPTEROYLASPARTICACID) . Harlem 

Hosp. Bull., N. Y., 1951, 4: 19-23. 9 refs. 

1598 

ASPARTIC ACID, PTEROYL - 

146 

Meyer, L. M. USE OF FOLIC ACID DERIVATIVES IN 

THE TREATMENTOF HUMANLEUKEMIA. Tr. N. York 

Acad. Sc., 1947-1948. 10: 99-103. 

See 

1035 

ATABR1NE 

see QUINACRINE 

AUREOMYCIN 

see CHLORTETRACYCLINE 

AvroiN 

See: 

251 1774 

AXEROPHTHOL 

see VITAMIN A 

2-AZAADENINE 

see IMIDAZO-1, 2, 3-TRIAZINE 

2-AZAADENINE, 

ATEBRIN 

see QUINACRINE; ACRIDINE, 6-CHLORO-2-METHOXY- 

9-a-DIETHYLAMINO-fÃ®- PENTILAMINO- 

8-HYDROXYsee 

IMIDAZO-1,2,3-TRIAZINE 

8-AZADENINE 

see 1-H-v-TRIAZOLO [d] PYRIMIDINE, 7-AMINO- 

8-AZAGU ANIÃ‘E 

see 1 H-V-TRIAZOLO [d] PYRIMIDINE, 5-AMINO- 

7 HYDROXY 

2-AZAHYPOXANTHINE 

AZASERINE 

see L-SERINE, 

8-AZAXANTHINE 

see IMIDAZO-1,2, 3-TRIAZINE, 6-HYDROXY- 

O-DIAZOACETYL- 

147 

Flint. T. J., Hirschberg, E. and Murray, M. R. 

COMPARATIVE EFFECTS OF CHEMOTHERAPEUTIC AGENTS 

ON BROWN-PEARCE TUMOR AND NORMAL RABBIT TESTIS 

IN VITRO. Proc. Soc. Exp. Biol., N. Y., 1953, 

84: 493-496. 10 refs. 8-Azaxanthine and 1, 

4Tdimethane-sulfonyloxybutaneshoved no inhi 

bitory effect on the Brown-Pearce tumor, while 

8-azaguanine and benzimidazole at 0.005 M 

concentration inhibited the tumor growth. 

See 

3516 

AZIRIDINE 

see ETHYLENIMINES 

AZO COMPOUNDS 

see also DYES 

148 

Seligman, A. M., Gofstein, R. M. and Friedman, 

O. M. THE INHIBITION OF TUMOR GROWTH IN MICE 

AND RATS 

1952, 5: 

WITH AZO 

613-619. 

COMPOUNDS. 

24 refs. 

Cancer, N. Y 

Abstracted in: 

Chem. Ibstr., 1952, 46: 7218Ã•. 

See: 

1745



12 

BACILLUS 

see BACTERIA 

BACTERIAâ€” EFFECT 


149 

Â«BronshteÃ¯n-Cherkes, F. K. VLIIANIE NEKOTORYKH 

SHTAM1IOV STAFILOKOKKA NA HOST EXPERIMENTAL'NOI 

SARKOMY KROKERA. [THE EFFECT OF SOME STAPHYLO- 

COCCAL STRAINS ON THE GROWTH OF EXPERIMENTAL 

CROCKER SARCOMA.] 170 p. Disser. Hoskva, 

19474 Abstracted in: Sov. med. rÃ©f. obozr., 

No. 1, 1949, p. 10. "Experiments were con 

ducted on 700 mice. Live staphylococcus iso 

lated from disintegrating tumors or staphylococcal 

toxin was given to 281 mice with trans 

planted Crocker sarcoma. In 97 mice tumor 

necrotization, and in 60 mice total disappear 

ance of tumor was observed. Of the 284 con 

trol animals none survived. The staphylococcal 

strain lost its 

when grown in vitro." 

[anti-tumor] properties 

-Sov. med. reÃ. obozr. 

ISO 

Cohen, A. L., Borsook, H. and Dubnoff, J. W. 

THE EFFECT OF A SPOROSARCINA UREAE PREPARA 

TION ON TUMOR CELLS IN VITRO. Proc. Soc. 

Exp. Biol., N. Y., 1947, 66: 440-444. 8 reÃs. 

Abstracted in: Excerpta mea., Sect. 5, 1948, 

1: No. 1018. 

151 DJanian, A. Y., Shanklin, W. M. and Butros, J. M. 

EFFECT OF TUBERCLE BACILLI EXTRACTS ON INDUCED 

TUMOURS OF THE RAT. Cancer Res., 1949, 9: 

520-525. 27 refs. The protein, phospholipoid 

and polysaccharide fractions of Mycobacterium 

tuberculosum were 

methyl-cholanthrene induced 

injected into 

spindle-celled 

carcinomas in the rat. Neither measurement 

of growth nor histological studies gave evi 

dence of destructive changes of the tumor 

tissue. The three fractions were injected in 

the inguinal region of control rats. The 

phospho-lipoid fraction produced typical 

tubercles. 

152 

Grabchenko, I. M, and Podll'chank, M. D. VLIIANIE 

STAFILOKOKKOVOI I STREPTOKOKKOVOI INFEKTSII NA 

RAKOVUIU OPUKHOL'. [EFFECT OF STAPHYLOCOCCAL 

AND STREPTOCOCCAL INFECTIONS OK CANCER.] Tr. 

Akad. med. nauk SSSR, 1952, 21: 233-237. 

Neither streptococcal nor staphylococcal in 

fections caused tumor regression. Of 20 mice 

with experimental tumors only 2 showed tumor 

regression when streptococcus pyogenous in 

fection was induced. 

153 Ito H. INFLUENCE OF SHWARTZMAN'S COLI-FILTRATE 

ON THE GROWTH OF THE TRANSPLANTED FRUCTOSE- 

SARCOMA IN THE MOUSE. III. Gann, Tokyo, 

1950, 41_: 160-161. 

154 Ito, H. STUDY OF THE INFLUENCE OF SHWARTZMAN'S 

COLI-FILTRATES ON THE GROWTH OF THE TRANS 

PLANTED FRUCTOSE-SARCOMA IN THE MOUSE. II 

REPORT. Gann, Tokyo, 1949, 40: 155-156. 

In Japanese. 

155 Kelly, T. A. and McDowell, M. A. STUDIES IN 

VITRO AND IN VIVO ON THE EFFECTS OF A STAPHYLO 

COCCUS AUREUS EXTRACT ON MOUSE CARCINOMA. 

Cancer Res., 1948, 8: 495-499. 17 refs. 

156 Â»Nagata, T. THE EFFECT OF THE FILTRATES OF 

VARIOUS BACTERIA IN THE CONTROL OF THE 

YOSHIDA SARCOMA. Tohoku igaku zassi, 1948, 

38; 135-143. 

157 Nagata, T. INHIBITING EFFECTS OF VARIOUS BAC 

TERIAL FILTRATES ON THE RAT ASCITES SARCOMA 

(YOSHIDA SARCOMA). Gann, Tokyo, 1948, 39: 

118-123. In Japanese. English summary. 

Nagata, T. and Nagao, I. EFFECT OF VARIOUS 

FRACTIONS OF TYPHOID BACILLUS FILTRATE UPON 

THE YOSHIDA SARCOMA. Gann, Tokyo, 1949, 40: 

142-144. In Japanese. 

159 

Parker, R. C., Plummer, H. C., Siebenmann, C. O. 

and Chapman, M. G. EFFECT OF HISTOLYTICUS 

INFECTION AND TOXIN ON TRANSPLANTABLE MOUSE 

TUMORS. Proc. Soc. Exp. Biol., N. Y., 1947, 


Sect. 5, 1948, 1: No. 1008. 

160 

Reilly, H. C. MICROBIOLOGY AND CANCER THERAPY; 

A REVIEW. Cancer Res., 1953, 13: 821-834. 

146 refs. The effects of bacteria, fungi, 

protozoa, antibiotics and viruses on tumors 

are discussed. 

161 

Rondoni, P. ANCORA SULLA BACTERIOTERAPIA DEI 

TUMORI. [MORE ON THE BACTERIO-THERAPY OF 

TUMORS.] Terapia, Milano, 1947, 32: 69-70. 

Abstracted in: Excerpta med., Srct. 5, 1948, 

1: No. 320. A review. 

162 

SÃ¤len, S. A., Eissa, A. A. and Gohar, M. A. 

THE EFFECT OF INFECTION ON MALIGNANCY. J. 

Egypt. M. Ass., 1952, 35: 347-354. 7 refs. 

Injection of Staphlococcus aureus, Pseudomonas 

aeruginosa and Mycobacterium tuberculosis into 

the tumor mass produces a retrogressive growth 

of the tumor. Intrapertoneal infection with 

the tubercle bacillus fails to affect the 

course of the tumor. 

See: 

91 1769 

THERAPY 

see also INFECTIOUS DISEASES â€”¿ THERAPY 

163 Barnard, R. D. STREPTOMYCES FERMENTATION DERI 

VATIVES IN ACUTE LEUKAEMIA. Lancet, Lond., 

1951, U 1157-1159. 12 refs. 

164 Compton, A. EFFECT OF A PHAGE-LYSATE OF IN 

TESTINAL BACTERIA ON THE OSSEOUS METASTASES 

OF MAMMARY CANCER (PRELIMINARY COMMUNICA 

TION) . J. Egypt. M. Ass., 1948, 31: 12-14. 

rÃ©f. 

165 

Komis, A. L'ACTION DE L'APOSTAXINE DE TUBER- 

CULINE BRUTE SUR LES LEUCÃ‰MIES. [THE ACTION 

OF APOSTAXINE OF NATURAL TUBERCULIN ON THE 

LEUKEMIAS.] Acta UniÃ³ internat, cancr., 

Louvain, 1952, 8: 546-547. 25 refs. Ab 

stracted in: Leukemia Abstr., 1953, 1L:No. 

111. "...injection of a distillate of 

tuberculine called Apostaxine has a favour 

able influence on the evolution of the lymphoid 

leukemia in adults." 

166 

KomÃªs, A. EPIDEIXIS PERIPTÃ–SEOS KARKINOU TOU 

OPTHALMOU KAI TOU KONCHOU THERAPEUTHEISA 

DI'APOSTAXO-KATALYTINON. [PRESENTATION OF 

A CASE OF CANCER OF THE EYE AND THE CAVITY 

OF THE EYE TREATED BY APOSTAXINS AND CATA- 

LYTINS. ] Bull. Soc. med. chir. Athens, 

1947, 32: 215.



13 

BACTERIA 

â€”¿ THERAPY 

(Continued) 

Herrmann, K. O. DIE THERAPEUTISCH GÃœNSTIGE 

BEEINFLUSSUNG DER KREBSKRANKHEIT MIT HILFE 

DER ZUSATZLICHEN ANSIEDLUKG EINER GESUNDEN 

DARMFLORA. [FAVORABLE RESULTS OF CANCER 

THERAPY OBTAINED BY THE ADMINISTRATION OF 

INTESTINAL BACTERIA.) Munch, med. Wschr., 

1952, 94: 1123-1126. 20 refs. 

168 

Lavedan, J. and Courtial, L. LES TENTATIVES DE 

TRAITEMENT DU CANCER AU MOYEN DE SUBSTANCES 

D'ORIGINE MICROBIENNE. [TRIALS 0F CANCER 

THERAPY WITH COMPOUNDS OF BACTERIAL ORIGIN.] 

Paris ned., 1949, 39: 193-198. 31 refs. 

BACTERIA, POLYSACCHARIDES â€”¿ EFFECT ON 

TUMOR GROWTH 

169 

Ikawa, M., Koepfli, j. B., Mudd, S. G. and 

Nlemann, C. AN AGENTFROME. COLI CAUSINr 

SSSf Tâ„¢LANDTREGWassION OF Â« SEMENTAL 

MOUSE TUMOR. I. ISOLATION AND PROPERTIES 

17 rlÃ®s CanCer lDSt" 1952. H: 157-166. 

170 

Ikawa, M., Koepfli, j. B., Mudd, S. G. and 

Niemann, C. AN AGENT FROM ESCHERICHIA COI I 

CAUSING HEMORRHAGE AND REGRESSION OF AN 

Tâ„¢ - . F 

THE AGENT IN THE PRESENCE OF VARIOUS REAGENTS 

J. Nat. 

11 refs. 

Cancer Inst . , 1954, 

"From a study of 

14: 1195-1201 

tHÃ«action of 

various chemical and enzymatic reagents upon 

the mouse tumour-haemorrhagic agent from E 

coli, it has been concluded that tumourhaemorrhagic 

activity is associated with the 

presence of an intact lipopolysaccharide Â» 

171 

Freiman, V.â€žB. EXPERIMENTAL'NYE MATERIALYPO 

IZUCHENIIU VLIIANIIA NEKOTORYKHBAKTERIINYKH 

PRODUKTOVNA ROST OPUKHOLEIZHIVOTNYKH. 

[EXPERIMENTALDATAFOR THE INVESTIGATION OF 

THE EFFECT OF CERTAIN BACTERIAL PRODUCTSON 

GROWTHOF TUMORSIN ANIMALS.] 

nauk SSSR, 1952, 21: 224-233. 

Tr. Akad. 

11 refs. 

Â»ed. 

Strains 

directly 

of StaphylÃćoccus 

into the Crocker 

aureus 

sarcoma 

introduced 

caused 

necrotizing of tumor tissue as well as tumor 

regression. Intradermal injections of polysaccharide 

fraction of StaphylÃćoccus not 

given intratumorally did not inhibit tumor 

growth . 

See 

187 2750 

BACTERIA. TOXINS â€”¿ EFFECT ON TUMOR GROWTH 

172 

Roskin, G. TOXIN THERAPY OF EXPERIMENTAL CANCER 

THE INFLUENCE OF PROTOZOAN INFECTIONS UPON 

TRANSPLANTED CANCER. 

363-365. Abstracted 

Cancer Res., 1946, 6: 

in: Chem. Abstr., Ã•947, 

41: 218a. Also in: Am.. Rev. Soviet M., 1946 

TT 111-115. Infection with Schizotrypanum 

cruzi inhibited the development of trans 

planted Ehrlich carcinoma and caused regression 

of tumor growth in one patient. Diphtheria and 

tetanus toxins also showed oncolytic effects. 

173 Roskin, G. I. and Khaikina, M. I. LECHÃ•NIE 

PEREVIVAIUSHCHIKHSÃ•A I SPONTANNYKH OPUKHOLEI 

DIFTERIINYM TOKSINOM. [TREATMENT OF TRANS 

PLANTED AND SPONTANEOUS TUMORS WITH DlPh- 

THERIA TOXIN.] BÃ•U1. eksp. biol. med., 

22: NÂ». 1, 13-16.' Eighty-twÂ» mice with 

1946, 

trans 

planted Cracker sarcoma and tumor 63, and 40 

mice with spontaneous tumors were treated 

with 25 Injections of 0.0032 Dim diphtheria 

toxin (in doses of 0.25 cm3, diluted 1:50) 

over a period of twenty days. The toxin had 

far greater effects on the spontaneous tumors 

even given when 

growth of 2.5-3 

the 

cm. 

tumor had reached maximum 

Out of 40 mice, 18 showed 

inhibition of tumor growth and 15 showed com 

plete tumor regression. In transplanted tu 

mors very slight effect occurred. They oc 

curred only when the toxin was applied im 

mediately following transplantation of tumprÂ«. 

174 

Wells, G. C. STUDIES ON THE REPRESSION OF NEO 

PLASM BY BACTERIAL TOXINS. M. D., Chic.. 

1947, 2: No. 12, 21-24. 4 refs. 

175 ^ 

Zaeva, S. P. TERAPIIA ZLOKACHESTVENNYKH 

OPUKHOLEI BAKTERIINYMI TORSINAMI. [TREAT 

MENT OF MALIGNANT TUMORS WITH BACTERIAL 

TOXINS.] Tr. Akad. nauk Latv. SSR., Inst. 

eksp. med. Vopr. klin. lech, zlokachst. 

novoobraz., 1953, 1: 117-133. 19 refs. 

Following a review~of Russian literature 

on the oncolytic effect of bacterial 

toxins, the effects of tetanus, diphtheria 

and streptococcal infections on Crocker 

mouse sarcoma, Ehrlich mouse adenocarcinoma 

and M and No. 465 rat sarcomas in 521 

animals are discussed. None of the toxins 

inhibited tumor growth. 

176 

Zahl, P. A. ACTION OF BACTERIAL TOXINS ON TU 

MORS. VIII. FACTORS IN THEIR USE FOR CANCER 

THERAPY. J. Nat. Cancer Inst.. 1950. 11: 

279-288. 19 refs. 

. TOXINS, COLBY'S-THERAPY 

177 

Coley, B. L. EFFECTS OF BACTERIAL PRODUCTSON 

TUMORSOF BONE. In his: Neoplasms of Bone, 

N. T., Hoeber, 1949, 565-570. 

178 

Nauts, H. C. and Coley, B. L. A REVIEW OF THE 

TREATMENT OF MALIGNANT TUMORS BY COLEY BAC 

TERIAL TOXINS. In: Approaches to Tumor Chemo 

therapy. (American Association for the Ad 

vancement of Science) (1945-1946) 1947, 217- 

235. Approx. 90 refs. The greater part of 

this review appears in: Cancer Res., 1946, 

6: 205-216. 

179 

Nauts, H. C., Fowler, G. A. A. and Bogatko, F. H. 

A REVIEW 

TION AND 

OF 

OF 

THE INFLUENCE OF BACTERIAL INFEC 

BACTERIAL PRODUCTS (COLEY'S TOXINS) 

ON MALIGNANT TUMORS IN MAN. Acta med. scand., 

1953, 145: Suppl. No. 276, 103 p. 116 refs. 

180 

Nauts, H. C., Swift, W. E. and Coley, B. L. 

THE TREATMENTOF MALIGNANTTUMORSBY BAC 

TERIAL TOXINS AS DEVELOPEDBY THE LATE 

WILLIAM B. COLEY, M. D., REVIEWEDIN THE 

LIGHT OF MODERNRESEARCH. Cancer Res., 

1946, 6: 204-216. 80 refs. 

18Stewart, F. W. EXPERIENCES IN SPONTANEOUS 

REGRESSION OF NEOPLASTIC DISEASE IN MAN. 

Texas Rep. Biol. M., 1952, 10: 239-253. 

3 refs. A review. In some of the cases 

cited a therapeutic agent, such as Coley's 

toxin or nitrogen mustard had been admin 

istered preceding regression of tumor. 

BACTERIA. 

see VACCINES 

BACTERIA. 

VACCINE 

SERRATIA MARCESCENS POLYSACCHARIDE 

182 Shear, M. J. SOME ASPECTS OF A JOINT INSTITU 

TIONAL RESEARCH PROGRAM ON CHEMOTHERAPY OF 

CANCER: CURRENT LABORATORY AND CLINICAL 

EXPERIMENTS WITH BACTERIAL POLYSACCHAHIDE 

AND WITH SYNTHETIC ORGANIC COMPOUNDS. I. 

SCOPE OF THE PROGRAM. In: APPROACHES TO 

TUMOR CHEMOTHERAPY. Wash"., Am. Ass. Advance. 

Sc., 1947, p. 236-241. 8 refs.



14 

BACTERIA. SERRATIA MARCESCENS POLYSACCHARIDE â€”¿ 


183 

Hellbrunn, L. V. and Wilson, W. L. EFFECT OF 

BACTERIAL POLYSACCHARIDEON CELL DIVISION 

Science, 1950, 112: 56-57. 14 refs 

Abstracted In: CEern. Abstr., 1950, 44: 9514d. 

184 

Meier. R. and SchÃ¤r. B. SPEZIFISCHE WIRKUNG 

EINIGER TIERISCHER UND BAKTERIELLER POLY 

SACCHARIDE AUF LEUCOCYTEN IN VITRO. [THE 

SPECIFIC ACTION OF SOHE ANIMAI. AND BACTERIAL 

POLYSACCHARIDES ON LEUCOCYTES IN VITRO.] 

Experientia, Basel, 1954, 10: 376-377. 9 

refs. Abstracted in: Chem7~Abstr., 1955, 

49: 1113d. 

185 

Poel, W. E., Belkin, M. and Chagnon, C. L. 

VARIATIONS IN EOSINOPHIL MORPHOLOGY AND LEU 

COCYTE COUNTS IN THE RAT FOLLOWING INJECTION 

OF A TUMOR-NECROTIZING BACTERIAL POLYSACCHA 

RIDE. Am. J. Physiol., 1952, 169: 453-459 

25 refs. 

â€”¿EFFECT ON TUMOR GROWTH 

186 

Cantero, A. and Simard, L. C. A STUDY OF THE 

TUMOR NECROTIZING EFFECTS WITH S. MARCENSCENS 

POLYSACCHARIDE IN MICE; TRANSPLANTED SARCOMAS 

(S-37). Rev. brasil, cancerol., 1951, 4: 

48-50. The Serrata Marcenscens polysaccharide 

has a definite cytotoxic action on S-37 sar 

coma bearing mice. Pyridoxine hydrochloride 

enhances the cytotoxic activity of the poly 

saccharide but also increases the mortality 

rate. 

187 

Creech, H. J. and Hankwitz, R. F., Jr. BIOLO 

GICAL PROPERTIES OF POLYSACCHARIDE-LIPID 

COMPLEXES OBTAINED FROM SERRATIA MARCESCENS 

AND ESCHERICHIA COLI. Cancer Res., 1954, 14: 

824-829. 7 refs. The lethality, haemorrhage- 

and necrosis-producing capacity 

ability to produce tolerance, and activity in 

causing tumour regression in young Swiss mice 

of several polysaccharide-lipid complexes 

from SerrÃ¢tia marcescens and other organisms 

were studied. 

188 

Creech, H. J., Hamilton, M. A. and Diller, I. c 

COMPARATIVE STUDIES OF THE IMMUNOLOGICAL, TOXIC 

AND TUMOR-NECROTIZING PROPERTIES OF POLYSACCHA 

RIDES FROM SERRATIA MARCESCENS (BACILLUS PRO- 

DIGIOSUS). Cancer Res., 1948, 8: 318-329 

15 refs. 

189 

Diller, I. C. SOME ASPECTS OF A JOINT INSTITU 



EXPERIMENTS WITH BACTERIAL POLYSACCHARIDE 

AND WITH SYNTHETIC ORGANIC COMPOUNDS. VIII 

NUCLEAR CHANGES PRODUCED BY S. MARCESCENS 

(B. PRODIGIOSI.'Â»)POLYSACCHARIDE. In: 

APPROACHES TO TUMOR CHEMOTHERAPY. "Wash., 

Am. Ass. Advance. Sc., 1947, p. 260-264. 

3 refs. 

190 

Diller, I. C. DEGENERATIVE CHANGES INDUCED IN 

TUMOR CELLS BY SERRATIA MARCESCENS POLYSACCHA 

RIDE. Cancer Res., 1947, 7: 605-626. 18 refs 

Abstracted in: Chem. AbstrT, 1948, 42: No 

8323h. 

191 

Lasfargues, E. Y. L., Wharton, D. R. A. and 

DiFine, J. C. SOME EFFECTS OF POLYSACCHARIDE 

ÂBÃ•TIONS FRO" SERRATIA MARCESCENS AND 

AEROBACTER AEROGENES ON CELLS IN TISSUE CUL 

TURE. Cancer Res., 1951, 11: 425-427. 6 refs. 

192 

McConnell, J. R., Ballett, s. F. and shear, M. J. 

See 

193 

3090 

TÛMOR-NECROTIZINGÂGENTS.Cancer Res., 1947, 

METABOLISM 

â„¢¿ODÃœCT IN AN 

194 

Seligman, A. M., Shear, M. J., Leiter, J. and 

Sweet, B. CHEMICAL ALTERATION OF POLYSACCHA 

RIDE FROM SERRATIA MARCESCENS. I. TUMOR- 

NECROTIZING POLYSACCHARIDE TAGGED WITH RADIO 

ACTIVE IODINE. J. Nat. Cancer Inst., 1948, 

9: 13-18. 14 refs. Abstracted in: Chem. 

Abstr., 1949, 43: 6736g. 

- PHARMACOLOGICAL AND PHYSIOLOGICAL EFFECTS 

195 

Algire, G. H., Legallais, F. Y. and Anderson, 

B. F. VASCULAR REACTIONS OF NORMAL AND MALIG 

NANT TISSUES IN VIVO. V. THE ROLE OF HYPO 

TENSION IN THE ACTION OF A BACTERIAL POLY 

SACCHARIDE ON TUMORS. J. Nat. Cancer Inst., 

1952, 12: 1279-1295. 2 pi. 34 refs. The 

tumor-necrotizing effect of the Serratia 

marcescens polysaccharide is brought about 

by the ischemia and circulatory stasis in 

duced by hypotension. 

196 

Algire, G. H., Legallais, F. Y. and Park, H. D. 

VASCULAR REACTIONS OF NORMAL AND MALIGNANT 

TISSUES IN VIVO. II. THE VASCULAR REACTION 

OF NORMAL AND NEOPLASTIC TISSUES OF MICE TO 

A BACTERIAL POLYSACCHARIDE FROM SERRATIA 

MARCESCENS(BACILLUS PRODIGIOSUS) CULTURE 

FILTRATES. J. Nat. Cancer 

53-62. 2 pi. 21 refs. 

Inst., 1947, 8: 

197 Beck L V SOME ASPECTS OF A JOINT INSTITU 


CANCER: CURRENT LABORATORY ANDCLINICAL 

EXPERIMENTS WITHBACTERIAL POLYSACCHARIDE 

ANDWITHSYNTHETIC ORGANICCOMPOUNDS. IX. 

TEMPERATURE CHANGES PRODUCED IN MICE WITH 

S. MARCESCENS POLYSACCHARIDE. In: APPROACHES 

TO TUMOR CHEMOTHERAPY. Wash., Am. Ass. 

Advance. Sc., 1947, p. 265-270. 8 refs. 

198 

Beck, L. V., Diller, I. C., Blauch, B. and 

Fisher, M. REDUCTION IN TOXICITY OF SERRATIA 

MARCESCENS POLYSACCHARIDE TO TUMOR-BEARING 

MICE PRODUCED BY UPJOHN CO. BEEF ADRENAL 

EXTRACT. Cancer Res., 1947, 7: 725-726. 

199 

Beck, L. V. and Fisher, M. PHYSIOLOGICAL STUDIES 

ON TUMOR-INHIBITING AGENTS. II. EFFECT ON 

RECTAL TEMPERATURES 

SERRATIA MARCESCENS 

IN NORMAL RABBITS 

TUMOR-NECROTIZING 

OF THE 

POLY 

SACCHARIDE OF SHEAR. Cancer Res., 1946, 6: 

410-420. 16 refs. Abstracted in: Chem. 

Abstr., 1947, 4_l: 7505d.



15 

BACTERIA. SERRATIA MARCESCENS POLYSACCHARIDE - 


200 Beck, L. V., Berkowitz, D. and Seltzer, B. 

PHYSIOLOGICAL STUDIES ON TUMOR-INHIBITING. 

III. EFFECT ON APPARENT SYSTOLIC BLOOD PRES 

SURE IN Â»ICE OF THE SERRATIA yARCESCENS TUMOR- 

NECROTIZING POLYSACCHARIDE OF SHEAR. Cancer 

Res., 1948, 8: 162-168. 8 refs. 

201 Beck, L., Berkowitz, D. and Seltzer, B. SYSTOLIC 

BLOOD PRESSURE IN NORMAL AMD TUMOR-BEARING MICE 

AS AFFECTED BY THE SERRATIA MARCESCENS TUMOR 

NECROTIZING POLYSACCHARIDE OF SHEAR. Anat. 

Ree., 1946, 96J 536. 

202B â€¢¿elkin, M. and Bueker, E. D. HISTOCHEMICAL 

PHOSPHATASE REACTION IN MOUSE SARCOMAS CR 180 

AND 37 FOLLOWING ADMINISTRATION OF BACTERIAL 

POLYSACCHARIDE. Cancer Res., 1947, T\ 725. 

An abstract. "The cytotoxic effect of bac 

terial polysaccharide on implanted sarcoma 

in mice was not mediated through attenuation 

or destruction of phosphatase in the tumor 

til-sue." 

203 Most, S. EFFECT OF SHEAR'S POLYSACCHARIDE ON 

PLASMA CLOTTING. Nature, Lond., 1951, 168: 

342-343. 3 refs. Abstracted in: Excerpta" 

med., Sect. 2, 1952, 5: No. 2880. 

204 

Westfall, B. B. and Dunn, T. B. BLOOD URIC 

ACID AND PROTEOSE, BODY TEMPERATURE, AND 

GLOMERULAR CLEARANCE OF RABBITS 

WITH THE BROWN-PEARCE CARCINOMA 

IMPLANTED 

AND TREATED 

WITH THE POLYSACCHARIDE FROM SERRATIA MAR 

CESCENS. 

115-121. 

J. Nat. Cancer Inst., 1947, 7: 

24 refs. Abstracted in: Chem. 

Abstr., 1947, 41: 4849a. 

THERAPY 

205 Holloman, A. L. SOME ASPECTS OF A JOINT INSTI 

TUTIONAL RESEARCH PROGRAM ON CHEMOTHERAPY OF 



AND WITH SYNTHETIC ORGANIC COMPOUNDS. XI. 

REACTIONS OF PATIENTS AND OF TUMORS TO IN 

JECTION OF S. MARCESCENS POLYSACCHARIDE IN 

EIGHT CASES OF MALIGNANT DISEASE. In: 

APPROACHES TO TUMOR CHEMOTHERAPY. Wash., 

Am. Ass. Advance. Sc., 1947, p. 273-276. 

2 refs. 

206 

Oakey, R. SOME ASPECTS OF A JOINT INSTITUTIONAL 

RESEARCH PROGRAM ON CHEMOTHERAPY OF CANCER: 

CURRENT LABORATORY AND CLINICAL EXPERIMENTS 

WITH BACTERIAL POLYSACCHAHIDE AND WITH SYN 

THETIC ORGANIC COMPOUNDS. XII. REACTIONS 

OF PATIENTS TO INJECTION OF S. MARCESCENS 

POLYSACCHAHIDE IN NINE FURTHER CASES OF MALIG 

NANT DISEASE. In: APPROACHES TO TUMOR CHEMO 

THERAPY. Wash.~Am. Ass. Advance. Sc., 1947, 

p. 277-278. 4 refs. 

207 

Reimann, S. P. SOME ASPECTS OF A JOINT INSTI 

TUTIONAL RESEARCH PROGRAM ON CHEMOTHERAPY OF 



AND WITH SYNTHETIC ORGANIC COMPOUNDS. XIII. 

CLINICAL PATHOLOGICAL CONSIDERATIONS, AND 

RESUME. In: APPROACHES TO TUMOR CHEMOTHERAPY. 

Wash., Am. Ass. Advance. Sc., 1947, p. 278- 

284. 8 refa. 

208 Reimann, S. P. and Nishimura, E. T. ATTEMPTS 

AT THE CHEMOTHERAPY OF CANCER. J. Michigan 

M. Sac.. 1949, 48: 453-457; 484. 3 refs. 


2: No. 3543; Chem. Abstr., 1951, 45: 3948e. 

209 sack T. and Seligman, A. M. CHEMICAL ALTERATION 

OF POLYSACCHARIDE FROM SERRATIA MARCESCENS. II. 

EFFECTS OF IODOPOLYSACCHARIDE IN PATIENTS WITH 

MALIGNANT TUMORS. J. Nat. Cancer Inst., 1948, 

9: 19-34. tab. 11 refs. 

- TOXICITY 

210 Creech, H. J. , Hamilton, M. A., Nishimura, E. T. 

and Hankwitz, R. F. THE INFLUENCE OF ANTI 

BODY-CONTAINING FRACTIONS ON THE LETHAL AND 

TUMOR-NECROTIZING ACTIONS OF POLYSACCHARIDES 

FROM SERRATIA MARCESCENS (BACILLUS PRODIGIOSUS) . 


MUNCIZmONPAGAINST THE LETHAL ACTIVITY OF 

POLYSACCHARIDE. Cancer Res., 1949, a. D



16 

BEE BREAD (POLLEN) (Continued) 

21*allon, H. TUMEURSMALIGNESET COUVAIN 

D'ABEILLES. [MALIGNANTTUMORSANDBEE NESTS.] 

Scalpel, Brux., 1955, 108; 553-559. 

BELLADONNA 

See: 

123 

BENGAL ROSE 

see ROSE BENGAL 

BENZACRIDINE 

216 Guerin, M. and Lacour, F. ETUDE DE L'ACTION DE 

DEUXCOMPOSESBENZACRIDINIQUESSUR LE CANCER 

EXPÃ‰RIMENTAL.[ACTION OF TWOBENZACRIDINE 

COMPOUNDSON EXPERIMENTALCANCER.] Bull. 

Ass. fr. cancer, 1949, 36: 77-79. 4 refs. 

Abstracted in: Chem. AbsTr., 1949, 43: 6742h. 

BENZAMIDINE, 4, 4'-(PENTAMETHYLENEDIOXY) DIâ€”¿ 


See 

3188 


PROCESSES) 

217 

Bichowsky-Slomnitzki, L. INHIBITORY ACTION OF 

DIAMIDINES AND STIMULATIVE EFFECT OF POLTAMINES 

ON ENZYMATIC ACTIVITIES OF ESCHERICHIA COLI 

AND MICROCOCCUS AUREUS. Arch. Blochem., N. Y., 



Chem. Abstr., 1951, 45: No. 2l2b. Pentamidine 

and stilbamidine produced marked reduction in 

dehydrogenase activity and caused inhibition 

of oxygen uptake, glycolysis and deamination 

in E. coli and M. aureus. Synthetic polyamines 

antagonized the diamines* effect on dehydro 

genase activity and completely abolished their 

effects on the other three activities. 

See: 


433 THERAPY 

218 

Heilmeyer, L. UEBER DIE FORMEN DES MYELOGENEN 

PLASMOCYTOMS (MYELOMS) UND SEINE THERAPEUTISCHE 

BEEINFLUSSUNG DURCH PENTAMIDIN. [TYPES OF 

MYELOGENIC PLASMOCYTOMA (MYELOMA) AND TREAT 

MENT WITH PENTAMIDINE.] Med. Klin., Beri., 

1948, 43: 400-401. Report on 4 cases; the 

treatment had no effect on 3 patients while 

one showed considerable improvement. 

219 

Horster, J. A. CHEMOTHERAPIEDER "RETIKULOSEN.' 

[CHEMOTHERAPYOF "RETICULOSES."1 Verh. Deut. 

Ges. inn. Med., 1949, 55: 408-409. 

20 Kirsch, J. and Vulpian, P. de TRAITEMENT DU 

MYELOME MULTIPLE PAR UNE DIAMIDINE. [TREAT 

MENT OF A CASE OF MULTIPLE MYELOMA WITH A 

DIAMIDINE.] Therapie, Par., 1951, 6: 231- 

232. 5 refs. Abstracted in: Excerpta med., 

Sect. 2, 1952, 5: No. 4006. 

221 

Ramioul, H. LE TRAITEMENT DU MYELOME MULTIPLE 

PAR LA PENTAMIDINE; RELATION D'UN CAS ET DIS 

CUSSION. [TREATMENT OF MULTIPLE MYELOMA BY 

PENTAMIDINE; REPORT OF A CASE AND DISCUSSION.] 

Acta clin, belg., 1950, 5: 523-539. 18 refs. 

"From a clinical point ol view the pain was 

reduced and the patient improved. No signi 

ficant blood changes were observed...but the 

treatment was followed by an increase of the 

absolute number of polynuclear cells asso 

ciated with a decrease of lymphocytes. X- 

rays studies did not show important changes 

although recalcification was observed..." 

222 

SÃ¨ze, S. de, Ordonneau, P., Dausset, J. and 

Brux, de UN NOUVEAU CAS DE MYÃŠLOMATOSE DÃ‰ 

CALCIFIANTE DIFFUSE (PLASMOCYTOSARCOME DE 

LA MOELLE OSSEUSE). Ã‰CHEC DU TRAITEMENT 

PAR LA PENTAMIDINE. [A NEW CASE OF DIFFUSE 

MYELOMATOUS DECALCIFICATION (PLASMOCYTO- 

SARCOMA OF THE BONE MARROW) . FAILURE OF 

PENTAMIDINE 

hop. Paris, 

TREATMENT.] Bull. 

1948, 64: 539-543. 

Soc. med. 

Abstracted 

in: Index analyt. cancer., Par., 1949, 20: 

No. 736. Virtually the same report is In: 

Rev. rhumat., Par., 1948, .15: 110-114. 

223 

Weidener, J. EIN BEITRAG ZUR KLINIK UNDTHERA 

PIE DES PLASMOCYTOMS. [CLINICAL ASPECTS AND 

THERAPYOF PLASMOCYTOMA.] Deut. med. J., 

1952, 3: 251-253. 

See 

3207 3208 3211 3212 3217 

BENZANTHRACENES 

â€”¿ EFFECT 


224 Elson, L. A. and Haddow, A. INHIBITORY ACTION 

OF 1,2,5.6-DIBENZANTHRACBNE ON GROWTH OF 

WALKER CARCINOMA 256 IN RATS MAINTAINED ON 

HIGH AND LOW PROTEIN DIETS. Brit. J. Cancer, 

1947, 1: 97-101. Abstracted in: Chem. Abstr., 

1949, 4~3: 306g. 

225 Hill. W. T., Stanger. D. W., Pizzo, A.. Riegel, B., 

Shubik, P. and Wartman, W. B. INHIBITION OF 

9,10-DIMETHYL-1,2-BENZANTHRACENE SKIN CARCINO- 

GENESIS IN MICE BY POLYCYCLIC HYDROCARBONS. 


Abstracted in: Chem. Abstr., 1952, 46: No. 4645c. 

22Seligman, A. M., Milden, M. and Friedman, O. M. 

A STUDY OF THE INHIBITION OF TUMOR GROWTH IN 

MICE AND RATS WITH 10-METHYL-l, 2-BENZANTHRA- 

CENE AND DERIVATIVES RELATED TO THE NITROGEN 

AND SULFUR BETA-CHLOROETHYL VESICANTS. 

Crncer, N. Y., 1949, 2: 701-706. tab. 28 

refs. Abstracted in: Biol. Abstr., Bait., 

1949, 23: No. 23816; Chem. Abstr., 1950, 44: 

5478Ã•.~ 

THERAPY 

227 Engelbreth-Holm, J. and Stamer, S. TREATMENT 

OF LEUKEMIAWITH 9,10-DIMETHYL-l,2-BENZAN- 

THRACENE. In: APPROACHESTO TUMORCHEMO 

THERAPY. Wash., Am. Ass. Advance. Sc., 1947, 

p. 419-430. 6 refs. "The treatment caused 

a'decrease in the number of leukemic cells 

that was in some cases striking. Diminution 

in size of enlarged lymph nodes and spleen 

was also noted."



17 

BENZENE 



228 

Flory, C. it,,Steinhardt, I. D. and Furth, J. 

FURTHER OBSERVATIONS ON THE EFFECT OF BENZENE 

ON A STRAIN OF HYELOID CHLOROLE UKEHIA IN MICE 

AND ON CHANGES PRODUCED IN THE LEUKEMIC CELLS 

BY THE CHEMICAL. Blood, N. Y., 1946, 1: 

367-378. 6 reÃs. 

See: 

130 1926 


235 

Hurray, H. R., Peterson, E. R., Hirschberg, E. 

and Pool, J. L. METABOLIC AND CHEMOTHERA- 

PEUTIC INVESTIGATION OF HUMAN GLIOBLASTOMA 

IN VITRO. 

1147-1171. 

Ann. N. York Acad. 

7 pi. 17 refs. 

Sc., 1954 58â€¢ 

' ' ~ 

See: 

147 1775 2869 

BENZMDAZOL, 

MERCAPTO- 

See: 

Baserga, A. and Marinone, G. CONTRIBUTO ALLA 

CONOSCENZA DELL'AZIONE DI ALCUNE SOSTANZE GITO- 

STATICHE SULLE CELLULE MIELOIDI; GENESI E 

SIGNIFICATO DELL "CELLULE MEGAMIELOIDI." [STUDY 

OF THE ACTION OF CERTAIN CYTOSTATIC SUBSTANCES 

ON BONE MARROW CELLS; ORIGIN AND SIGNIFICANCE 

OF "MEGAMYELOID CELLS."] Haematologica, Pavia, 


Excerpta" raed., Sect. 16, 1954, No. 3072. 

768 362 


230 

Aubertin, C. LA CHIMIOTHÃ‰RAPIE DES LEUCÃ‰MIES 

[CHEMOTHERAPY OF LEUKAEMIA] . Paris mid 

1947, 37: 260-266. 8 refs. Abstracted in- 

ExcerpTÃ¯ med., Sect. 2, 1948, l: No. 3770.' 

231 

Braier, L. TRAITEMENT DES LEUCOSES CHRONIQUES 

PAR LE BENZENE. ET SES HOMOLOGUES: LE RÃ”LE DES 

DONNEURS DE METHYLES. [TREATMENT OF CHRONIC 

LEUKEMIA .BY BENZENE AND ITS HOMOLOGS: THE 

ROLE OF METHYL DONORS.] Sang, Par., 1953, 

24: 603-612. 7 refs. Abstracted in: Leukemia 

SFstr., 1953, 1L: No. 381. 

See: 

125 135 

BENZENE, 

See: 

1761 

232 

Dameshek, W. CHEMOTHERAPYOF LEUKEMIAAND RE- 

2,4-DINITRO- 

BENZHYDRYL, 0-DIMETHYLAMINOETHYL- 

233 

Pogolotti, R. ANTISTAMINICI E ADENOCARCINOMA 

DI EHRLICH; RICERCHE SPERIMENTALI. [ANTI- 

HISTAMINS AND EHRLICH ADENOCARCINOMA: EX 

PERIMENTAL STUDIES.] Neoplasie, Tor., 1950 

4: 107-114. 8 refs. 

BENZIMIDAZOLE 

234 

Mantegazza, P., Mihich, E. and Tommasini, R. 

ATTIVITÃ€ DI ALCUNI DERIVATI PURINICI E PIRI- 

MIDINICI SULLA CRESCITA. NEL RATTO, DEL CAR 

CINOMA DI WALKER 256. [ACTIVITY OF VARIOUS 

PURINE AND PYRIMIDINE DERIVATIVES ON THE 

GROWTH OF THE WALKER 256 CARCINOMA IN RATS.] 

Boll. Soc. 

1732-1735. 

ital. 

tab. 

biol. spur., 

21 refs. 

1951, 27: 

3561 

BENZOIC ACID, p-AMINO â€”¿ EFFECT 

GROWTH 

236. 

ON TUMOR 

ÃBERDIE HEIMENDEWIRKUNGVON 

GROWTH EXPERIMENTAL TUMORS.] Zschr ges 

inn. Med., 1950, 5: 539-541. A minimum dose 

of 22.5 mg. of vitamin H' inhibited Ehrlich 

ascites tumor growth in mice; a concentra 

tion of 0.5 mg. of the compound per cc 

caused cytolysis of tumor cells in vitro. 

237 

Dobrovolskala-Zavadskala, N. and ChaÃ®ne, J 

L'EFFET DE L'ACIDE PARA-AMINOBENZOÃ•QUE (VITA 

MINE Hl) SUR LES ADENO-CARCINOMES MAMMAIRES 

DE LA SOURIS. [EFFECT OF P-AMINOBENZOIC ACID 

(VITAMIN HI) ON MAMMARY ADENOCARCINOMA IN 

THE MOUSE.] Bull. Ass. fr. cancer, 1952, 

39: 170-173. 14 refs. Abstracted in: Chen. 

Ã•Bstr., 1953, 47: No. 179h. 

238 

Passera, G. ACIDO PARAMINOBENZOICO E TUMORI 

[PARAAMINOBENZOIC ACID AND TUMORS.] 

Neoplasie, Tor. 1947, 2: 337-344. 16 refs. 

Vitamin HI (PABA) in doges of 1 mg injected 

into 20 albino mice inhibited the growth of 

Ehrlich adenocarcinoma, but did not decrease 

the loss in body weight. The survival time 

was prolonged. 


239 Mar, P. G. and Tchaperoff, I. C. C. RÃ–NTGEN 

IRRADIATION OF P-AMINOBENZOICACID SOLUTIONS. 

Science, 1951, 113: 549-551. 9 refs. 

THERAPY 

240 

Biche 1, J. AN ANTAGONISTIC EFFECT OF P-AMINO 

BENZOIC ACID AND SULFAPYRIDINE ON THE LEU- 

KOCYTECOUNT IN LEUKEMIA. 

21: 360-364. 9 refs. 

Sang, Par., 1950, 

241 

Bichel, J. EFFECT OF P-AMINOBENZOIC ACID ON 

THE LEUCOCYTE COUNT IN LEUKEMIA. Nature 

Lond., 1948, 161: 353. 3 refs. Abstracted 

in: Biol. AbsÃ¯FT, Bait., 1949, 23: No. 3932. 

242 

KeÃŽSÃ¯SniE- and TÃ©nyi, M. PARA-AMINOBENZOIC 

ACID IN HUMAN LEUKEMIAS. Nature, Lond 

1949, 163: 328. 3 refs. Abstracted in; 

ExcerpÃ¬sTined., Sect. 2, 1949, Â£: No. 6004. 

243 

May, H. B. and Vallance-Owen, J. PARA-AMINO 

BENZOIC ACID IN LEUKAEMIA; EFFECT ON THE 

LEUCOCYTE-COUNT. Lancet, Lond.. 1948, 2: 

607-609. 6 refs.



18 

BENZOIC ACID, p-AMINOâ€”THERAPY (Continued) 

244 , 

Zarafonetis, C. J. D., Curtis, A. C. and Kirkman, 

L. W. PARA-AMINOBENZOIC ACID THERAPY IN LYM- 

PHOBLASTOMA CUTIS AND MYCOSIS FUNGOIDES. 

Cancer, Phila., 1954, 7: 190-201. 12 refs. 

24~5 

Â»Zarafonetis, C. J. D., Andrews, G. A., Meyers, 

M. C. and Bethell, F. II. PARA-AMINOBENZOIC 

ACID IN LEUKEMIA. Blood, Bait., 1948, 3: 

780-792. 

See: 

1158 521 

See: 

2204 

BENZOPHENONES 

246 

Geschickter, C. F., Copeland, M. M. and Scholler, 

J. THE USE OF AMINO ACID ANTAGONISTS FOR THE 

INHIBITION OF TUMOR GROWTH. Bull. Georgetown 

Univ. M. Cent., 1951, 5: 67-73. 13 refs. 

BENZOPYRENE 

See 

1092 

BENZOQUINONE, p- 

see QUINONE, 

BENZOIC ACID, p-CHLOR-MERCURI- 

p-BENZO- 

BERBERINE 

247 

Schmitz, H. STORAGE OF BERBERINE IN THE GRA 

NULES OF TUMOR CELLS. Naturwissenschaften, 

1951, 38: 405. 

24lchmitz, H. ÃœBER DIE EINWIRKUNG VON ALKALOIDEN 

AUF DEN ZELLSTOFFWECHSEL. IV. UNTERSUCHUNGEN 

ÃœBER DEN ANGRIFFSPUNKT DES BERBERINS IM INTER 

MEDIÃ„REN STOFFWECHSEL. [INFLUENCE OF ALKALOIDS 

ON CELLULAR METABOLISM. IV. THE POINT OF 

ATTACK OF BERBERINE IN INTERMEDIARY METABOLISM.] 

Zschr. Krebsforsch., 1951, 57: 629-633. 15 refs. 

Abstracted in: Chem. Abstr,, 1952, 46: 4680ÃŒ. 

249 Schmitz H. ZUR BEEINFLUSSUNG DES ZELLSTOFFWECHSELS 

DURCH BERBERIN. [THE EFFECT OF BERBERINE ON CELL 

METABOLISM.] Zschr. Krebsforsch., 1950, 57: 

137-141. 7 refs. Abstracted in: Excerpta med., 

Sect. 5, 1951, 4: No. 2101. 

See 

2950 

BERYLLIUM 

250 Chevremont, M. and Firket, H. ACTION DU BERRYL- 

LIUM SUR LA CROISSANCE ET LA MITOSE EN CULTURE 

DE TISSUS. [THE EFFECT OF BERRYLLIUM ON THE 

GROWTH AND MITOTIC ACTIVITY OF TISSUE CULTURES.] 

C. rend. Ass. anat., 1951, 38^: 264-267. 7 refs. 

BIOTIN 

251 Mardashev, S. R. and Shomin, B. I. VLIIANIE 

BIOTINA NA PRIVIVAEMOST1 I RAZVITIE SARKOMY 

KROKERA. [THE EFFECT OF BIOTIN UPON THE 

TRANSPLANTATION AND DEVELOPMENT OF CROCKER 

SARCOMA]. Doklady Akad. nauk SSSR, 1949, 

65: No. 5,723-726. 6 refs. Subcutaneous 

injections of 2/g biotin, given daily to 

220 mice with transplanted Crocker sarcoma 

did not produce regression in tumors. Avidin 

and sulfoguanidin, on the other hand, ef 

fectively prevented the tumors from develop 

ing without, however, causing regression in 

the already developed tumors. 

BIOTIN, 

DESTHIO- 

252 Laszlo, D. CHEMOTHERAPEUTIC REGRESSIONS OF 

TRANSPLANTED AND SPONTANEOUS CANCERS IN 

MICE. II. STUDIES ON TUMOR GROWTH INHI 

BITORY SUBSTANCES. In: APPROACHES TO TUMOR 

CHEMOTHERAPY. Wash., Am. Ass. Advance. 

Sc., 1947, p. 148-156. 

1774 

BIPHENYL DERIVATIVES 

253 FÃ¼rst, A. and Freedlander, B. L. THE ACTION OF 

AMINOBIPHENYL DERIVATIVES ON THE GROWTH OF 

MOUSE SARCOMA-37. Stanford M. Bull., 1952, 

10: 308-309. 5 refs. 29 biphenyl compounds 

were tested. Marginal inhibiting effects 

were achieved with 4-diethylaminobiphenyl, 

benzidine, 3,3t-dimethylbenzidine, and 4- 

acetylbiphenyl. 

254 Leiter, J., Hartwell, J. L., Kahler, J. S., 

Kline, I. and Shear, M. J. DAMAGE INDUCED 

IN SARCOMA 37 WITH CHEMICAL AGENTS. VI. 

DIPHENYL, FLUORENE, PHENANTHRENE, AND TRO- 

POLONE DERIVATIVES. J. Nat. Cancer Inst., 

1953, 114: 365-374. 15 refs. 

BIRCH 

ASH 

255 

*Teir, H., PyÃrÃ¤lÃ¤,K. and Alna, A. R. INFLUENCE 

OF SOME MINERALS ON THE GROWTH AMD TRANSPLANTA- 

BILITY OF THE ITB TUMOR. Ann. med. exp. biol. 

fenn., 1953, 31: 181-187. 

256 Teir H., PyÃrÃ¤lÃ¤,K. and Alha, A. R. KOIVUN- 

TUHKAN VAIKUTUS PAHANLAATUISEEN ROTTAKASVAIMEEN. 

[THE EFFECT OF ASHES OF BURNED BIRCH ON A MALIG 

NANT RAT TUMOR.] Suom. lÃ¤Ã¤k.lehti, 1953, 8: 

387-391. Abstracted in: Excerpta med., Sect. 

16, 1954, 2: No. 116a. "In some parts of 

Finland ash~es of burned birch have been used 

in the treatment of cancer. These ashes have 

now been analysed and their effect on a rat 

tumour studied. No effect could be demonstrated. 

- Excerpta med. 

A-BLASTOMASE 

257 A-BLASTOMASE: ZUR BEHANDLUNG INOPERABLER 

BÃ–SARTIGER GESCHWÃœLSTE. fA-BLASTOMASE IN THE 

TREATMENT OF INOPERABLE MALIGNANT TUMORS]. 

Med. Mschr., 1955, 9: 268. 5 refs.



19 

BLOOD 

EXTRACTS 

258 

Mertens, V. E. NORMODYN UND PATHODYN. [NORMODYN 

AND PATHODYN.] Krebsarzt, Wien, 1949, 4: 2-15. 

Abstracted in: Excerpta med., Sect. 5, T949, 

2: No. 3550. "'Normodyn' and 'pathodyn' are 

extracted from blood by precipitation with 

acid alcohol. Pathodyn is found in pregnancy, 

cancer, erysipelas, pneumonia and tuberculosis... 

They are complicated mixtures and consist largely 

of inorganic material. Normodyn inhibits tumour 

growth." -Excerpta med. 

BONE MARROW â€”¿ THERAPY 

259 

Poumailloux, M and Sarniguet, P. RESULTATS 

DU TRAITEMENT DE DEUX CAS DE LEUCÃ‰MIE LYM- 

PHOIDE PAR DES EXTRAITS DE MOELLE OSSEUSE 

CONCENTRÃ‰E. [RESULTS OF TREATMENT OF TWO 

CASES OF LYMPHOID LEUKEMIA WITH CONCENTRATED 

EXTRACTS OF BONE MARROW.] Sang, Par., 1954, 

25: 284-289. 4 reÃe. It is thought that 

b~o~nemarrow extracts contain a factor for 

granulocytes, comparable to liver extract 

for red blood corpuscles. A highly concen 

trated extract has a more powerful effect 

upon myelold elements. 

260 

Rosenstein, P. HISTÃ“RICO DAS PESQUISAS PARA 

O TRATAMENTO DO CANCER COM 0 EMPRÃŠGO DE 

MEDULA OSSEA DE ANIMAIS JOVENS. [REPORT ON 

TREATMENT OF CANCER WITH BONE MARROW OF 

YOUNG ANIMALS.] Rev. brasil, med., 1947, 

4: 19-21. Bone marrow extract administered 

Ã¯b three patients with inoperable cancers 

caused tumor regression and improved over 

all condition of the patients. 

261 

TremblayÊ. C. LA MOELLE OSSEUSE EPIPHYSAIRE 

ADULTE A HAUTE DOSE DANS LES LEUCOSES AIGUÃ‹S. 

[ADULT EPIPHYSIAL BONE MARROWIN HIGH DOSAGE 

FOR ACUTE LEUKEMIA.] Bull. Soc. mÃ©d. hop. 

Paris, 1953, 69: 614-616. 5 refs. 

BROMIDES 

262 

ArraÃ§te y Ayestaran, J. M. EVOLUCIÃ“N 

CLÃ•NICA DE TUMORES DE DIVERSA LOCALIZACION 

TRATADOS CON POLIBROMUROS. 

OF TUMOURS IN VARIOUS SITES 

[CLINICAL COURSE 

TREATED WITH 

POLYBROMIDES.] Clin, laborat. Zaragoza, 


med., Sect. 5, 1949, 2: No. 1413. 

263 

BaÃ±uelos GarcÃa, M. CUXNTO TIEMPO PERSISTE LA 

CURACIÃ“N DEL CANCER DE ESTOMAGO LOGRADA CON 

TRATAMIENTO BROMURADO, Y CUANDO LOS ENFERMOS 

NO CURAN, EN CUANTO TIEMPO PUEDE CONSIDERASE 

PROLONGADA SU VIDA. [ON THE LENGTH OF A 

SUCCESSFUL CURE OF CANCER OF THE STOMACH 

TREATED WITH BROMINATED SUBSTANCES, AND ON 

THE SURVIVAL TIME IN INCURABLE CASES.] Gac. 

mÃ©d. espaH., 1947, 21: 145-149. 

264 

BaÃ±uelos GarcÃa, M. DE NUEVO SOBRE LOS ERRORES 

QUE MAS FRECUENTEMENTE SE COMETEN EN EL TRA 

TAMIENTO DE LOS CANCERES POR LOS COMPUESTOS 

BROMURADOS. [BROMIDE COMPOUNDS; FURTHER STUDY 

ON MOST FREQUENT MISTAKES IN THE TREATMENT OF 

CANCER.] Gac. mÃ©d. cspaÃ±., 1946, 20: 433- 

436. 

265 

BaÃ±uelos GarcÃa, M. LOS NUEVOS COMPUESTOS BRO 

MURADOS ANTICANCEROSOS. [NEW BROMINATED ANTI 

CANCER COMPOUNDS.] Gac. mÃ©d. esparÃ., 1947, 

21: 393-395. "A new brominated compound 

"^"preparation 10010, the chemical composition 

of which is not stated, has been tried in the 

treatment of malignant neoplasms. 

266 

BaÃ±uelos GarcÃa, M. TRATAMIENTO DE LOS CÃ•NCERES 

Y OTRAS VIRASIS CRÃ“NICAS POR COMPUESTOS DE 

BROMO. [TREATMENT OF CANCER AND OTHER CHRONIC 

VIRUS DISEASES WITH BROMIDE COMPOUNDS.] 148 p. 

Barcelona-Madrid-Valencia, Editorial cientifico 

mÃ¨dica, 1946. 

267 

MartÃnez RodrÃguez, R. BROMUROS Y CANCER. 

[BROMIDES AND CANCER.] Farmacoter. actual, 

Madr., 1948, 5: 396-404. 

268 

Romero Velasco, E. LA CURA POLIBROMURADA EN EL 

CANCER EXPERIMENTAL. I. EFFECTO CURATIVO EN 

EL SARCOMA POR METILCOLANTRENO DE LAS RATAS. 

[POLYBROMIDE TREATMENT OF EXPERIMENTAL CANCER. 

I. CURATIVE EFFECT IN METHYLCHOLANTHRENE- 

INDUCED SARCOMAS OF RATS.] Clin, laborat., 

Zaragoza, 1948, 45: 205-209. 

BUTANE, 1, 4-DIMETHANESULFONYLOXY - 

269 Timmis, G. M. 1:4-DIMETHANESULPHONYLOXYBUTANE 

(MYLERAN). Acta UniÃ³ intern, cancr., Louvain, 

1954, 10; 181. 2 refs. A discussion. 

EFFECT 


270 

Haddow, A. and Timmis, G. M. MYLERAN IN CHRONIC 

MYELOID LEUKAEMIA; CHEMICAL CONSTITUTION AND 

BIOLOGICAL ACTION. 

207-208. 4 refs. 

Lancet, Lond., 1953, 1: 


med., Sect. 16, 1954, 4: No. 199; Leukemia 

Abstr., 1953, 1: No. 107. 

See: 

235 320 2884 3481 


271 

Bollag, W. DER EINFLUSS VON MYLERAN AUF DIE 

KEIMDRÃœSEN VON RATTEN. [THE INFLUENCE OF 

MYLERAN ON THE GONADS OF RATS.] Experientia, 

Basel, 1953, 9: 268. "Male and female albino 

rats were treÃ¯ted with Myleran...The testes 

as well as the ovaries were badly damaged. 

The male germinal epithelium was completely 

destroyed. Oocytes and follicles were no 

longer present in the ovaries." 

272 

Bollag.,W. MYLERAN EIN NEUES CYTOSTATICUM BEI 

LEUKÃ„MIEN. [MYLERAN, A NEW CYTOSTATIC AGENT 

IN LEUKAEMIA.] Schweiz, med. Wschr., 1953, 


Sed., Sect. 16, 1954, No. 3170. 

273 

BoJ.lag,W. TIEREXPERIMENTELLE UNTERSUCHUNGEN 

ÃœBERDIE WIRKUNG EINIGER CYTOSTATICA AUF DAS 

BLUTBILD. [EXPERIMENTAL STUDIES ON THE EFFECT 

OF SOME CYTOSTATIC AGENTS ON THE BLOOD PIC 

TURE.] Schweiz, med. Wschr., 1953, 83: 1027- 

1029. 12 refs. "Myleran particularly inhibits 

the myeloid system, the aromatic Nitrogen Mus 

tard CB 1348 the lymphoid system. TEM and 

the aliphatic Nitrogen Mustard act on both 

systems to approximately the same extent." 

274 

Burgl, W. and Kellner, G. DER EINFLUSS VON 

MYLERAN AUF DAS WACHSTUM DER FOLLIKEL IM 

RATTENOVA. [THE INFLUENCE OF MYLERAN ON 

THE GROWTH OF THE FOLLICLES IN THE RAT 

OVARY.] Anat. Anz., 1954, 100: 322-325. 

6 refs.



20 

BUTANE, 1, 4-DIMETHANESULFONYLOXY-, â€”¿MODEOF 

ACTION 

See: 

282THERAPY3240 

275 Branco, F. and Gama, H. da. MYLERAN' NA TERA 

PEUTICA DA LEUCEMIA MIELOIDE CRONICA. [MY- 

LERAN IN THE TREATMENT OF CHRONIC MYELOOENOUS 

LEUKAEMIA.] J. Soc. ciÃªnc. mÃ©d. Lisboa, 1954, 

118: 459-466. The results of treatment of 

9 cases of chronic myelogenous leukaemia with 

myleran given orally in daily doses of 4-10 

mg are reported. Myleran caused regression 

of the splenomegaly, increase in body weight 

and improvement of the blood picture. The 

use of myleran is recommended in radio-resis 

tant cases. 

276 

Di Pietro, S. and Gallico, E. RÃ‰MISSIONTEMPO 

RAIRE INDUITE PAR LE 1,4-DIMÃ‰THYLSULFONYLOXY- 

BUTANE (MYLERAN) DANS UN CAS DE LEUCEMIE 

MYÃ‰LOID EN POUSSÃ‰EHÃ‰MOCYTOBLASTIQUE. [TEM 

PORARY REMISSION INDUCED BY l,4-DIMETHYLSUL- 

FONYLOXYBUTANE (MYLERAN) IN A CASE OF MYELOID 

LEUKEMIA IN HEMOCYTOBLASTIC ATTACK.] Sang, 

Par., 1955, 26: 434-438. 7 refs. 

277 

Erba, L. UN CASO DI LEUCEMIA MIELOIDE CRONICA 

TRATATO CON UN DERIVATO DEL BISMETIL-SULFC- 

NOSSIBUTANO. [A CASE OF CHRONIC MYELOID 

LEUKEMIA TREATED WITH A DIMETHYLSULFONYL- 

BUTANEDIOL DERIVATIVE]. Minerva med., Tor., 

1955, 46: 420-421. Dimethylsulfonyl butanediol 

was administered in daily 

The leucocyte count decreased, 

doses of 5 mg. 

thrombocytopenia 

disappeared and 8 day remissions occur 

red. 

278 

Galton, D. A. G. MYLERAN IN CHRONIC MYELOID 

LEUKEMIA. RESULTS OF TREATMENT. Lancet, 

Lond., 1953, 264: 208-213. 4 refs. Results 

in 19 cases. ~ 

279 Gigante, D., Teodori, S. and Zoppini, A. 

INDAGINI SPERIMENTALI SUI DIMETANOSULFO- 

NOSSIBUTANO E SUO IMPIEGO NELLA TERAPIA DELLA 

MIELOSI LEUCEMICA CRONICA. [EXPERIMENTAL 

STUDY OF DIMETHANESULPHONYLOXYBUTANE AND ITS 

USE IN THERAPY OF CHRONIC MYELOID LEUKEMIA.] 

Minerva med., Tor., 1955, 46: 221-227. 13 

refs. Fourteen cases are reported. 

280 

Hansen, P. B. EXPERIENCIA CLÃ•NICA DEL TRA 

TAMIENTO CON MYRELANO, ESPECIALMENTE EN LA 

LEUCEMIA MIELOIDE CRONICA. [CLINICAL DATA 

ON TREATMENT WITH MYLERAN, ESPECIALLY IN 

CASES OF CHRONIC MYELOID LEUKEMIA.] Fol. 

Clin. Internac., 1954, 4: 267-269. 2 refs. 

Abstracted in: Leukemia Abstr., 1955, 3J 

No. 1140. "...The average daily dose was 

6 mg during the first 4-6 weeks, after 

which it was decreased to 1-6 tablets a week. 

Frequent blood examinations were necessary 

to control the tendency toward thrombocytopenia. 

During the 20 months of observation 

of the 33 cases of chronic myeloid leukemia 

there were 20 cases of remission...6 cases 

of initial remission...and 7 cases of no 

remission..." 

281 Joerg, M. ERFAHRUNGEN MIT SULFABUTIN BEI..ZWEI 

FALLEN VON CHRONISCHER MYELOISCHER LEUKÃ„MIE. 

[EXPERIENCES WITH SULFABUTIN IN TWO CASES 

OF CHRONIC MYELOID LEUKEMIA.] Wien. med. 

Wschr., 1955, 105: 55-56. 

282 

Â»Kurrle, G. H. MYLERAN: A REVIEW OF ITS ACTION 

AND A REPORT ON ITS USE IN CHRONIC MYELOID 

LEUKEMIA. 

636-641. 

Med. J. Australia, 1955, 42: pt. 1, 

283 Â«Moloney, W. C. and Fuji!, T. THE USE OF MY 

LERAN IN THE TREATMENT OF CHRONIC MYELOGE 

NOUS LEUKEMIA IN ATOMIC BOMB SURVIVORS. 

Acta haemat. JapÃ³nica, 1954, 17: 120-121. 

In Japanese. Abstracted in: Leukemia Abstr., 

1954, 2: No. 994. 

284 "MYLERAN": A NEW APPROACH TO CHRONIC MYELOID 

LEUCHAEMIA. Med. J. Australia, 1953, 1: 

710. 

285 

Petrakis, N. L., Bierman, H. R., Kelly, K. H., 

White, L. P. and Shimkin, M. B. 

OF 1:4-DIMETHANESULFONYLOXYBUTANE 

THE EFFECT 

(GT-41 or 

MYLERAN) UPON LEUKEMIA. Cancer Phila., 1954, 

7: 383-390. 10 refs. Abstracted in: Leukemia 

Abstr., 1954, 2: No. 746. 

286 Ramiqul, H. CONTRIBUTION X L'Ã‰TUDEDE LA CHIMIO 

THERAPIE DE LA LEUCEMIE MYELOIDE; LE 1-4-DI- 

METHANE-SULPHONYL-OXY-BUTANE- (MYLERAN G. T. 41). 

[CHEMOTHERAPY OF MYELOID LEUKEMIA; 1,4-BUTANE- 

DIOL DIMETHYLSULFONYL ESTER (MYLERAN G. T. 41).] 

Rev. beige path., 1955, 24: 38-72. 13 refs. 

287 

Ramioul, H. LE 1-4 DIMETHANESULPHONYLOXYBUTANE 

(G. T. 41-MYLERAN) DANS LA LEUCÃ‰MIE MYELOIDE 

CHRONIQUE. [1,4-DIMETHANESULFONYLOXY BUTANE 

(G. T. 41-MYLERAN) IN CHRONIC MYELOID LEUKE 

MIA.] Acta UniÃ³ internat, cancr., Louvain, 

1955, lU 170-178. 8 refs. "Myleran G. T. 

41 represents an unmistakable progress in the 

treatment of chronic myeloid leukemia. Com 

plete clinical and hematological remissions 

are possible." 

288 Ramioul, H. NOUVELLE CHIMIOTHÃ‰RAPIEDE LA 

LEUCÃ‰MIEMYELOIDE; LE 1-4-DIMÃ‰THANE-SULFONYL- 

OXY-BUTANE(HYLERAN-G.T. 41). [PROGRESS IN 

CHEMOTHERAPY OF MYELOID LEUKEMIA: 1,4-BUTANE- 

DIOL DIMETHYLSULFONYL ESTER (MYLERAN, G. T. 

41).] Rev. mÃ©d. LiÃ¨ge, 1955, 10: 40-45. 

289 SuÃ¡rez, R. M., SuÃ¡rez, R. M., Jr., Sabater, J. 

and Buso, R. CLINICAL EXPERIENCE WITH MYLERAN 

IN THE TREATMENT OF LEUKEMIA. Bol. As. mÃ©d. 

Puerto Rico, 1955, 47: 93-102. tab. 10 refs. 

')Qfl 

Â»Videbaek, A. MYLERAN (GT 41) IN THE TREATMENT 

OF LEUKAEMIA. Acta med. scarni., 1955, 151: 

295-306. 

291 Wagner, K. KLINISCHE ERFAHRUNGEN MIT SULFABUTIN 

IN DER LEUKAM Â«BEHANDLUNG. [CLINICAL EXPERI 

ENCES WITH SULPHABUTIN IN THE TREATMENT OF 

LEUKEMIA.] Wien. med. Wschr., 1954, 104: 1002- 


Sect. 16, 1955, 3: No. 2781. 

See: 

535 

1228 

2733 

TOXICITY 

872 

2036 

3428 

915 

2045 

3454 

1185 

2325 

1206 

1470 

292 Bollag W CYTOSTATICA IN DER SCHWANGERSCHAFT. 

rCYTÃ“TOXIC AGENTS IN PREGNANCY.] Schweiz, med. 

Wschr., 1954, 84: 393-395. 7 refs. Abstracted 

in: Excerpta m53., Sect. 16, 1954, 2: No. 5020.



BUTAZOLmiNE 

-EFFECT 


see PYRAZOLroiNE, 3,5-DIOXY-l, 2-DIPHENYL-4-BUTYL- 

BUTYRIC ACID, 2-AMINO-4 (ETHYLTHIO)- 

see ETHIONINE 

BUTYRIC ACID, 

BROMO- AND CHLORO- 

293 Watson, J. A CHEMICAL TEST FOR THE PRESENCE 0F 

CANCER; ITS EARLY DETECTION AND DESTRUCTION 

BY THE SELECTIVE ACTION 0F BROMO- AND CHLORO- 

BUTYRATES. Med. Press b Cire., Lond., 1946, 

215: 128-129. 

CACODYLIC 

ACID 

294 

Asano, T. EFFECT OF CACODYLIC ACID UPON THE 

YOSHIDA SARCOMA. Tohoku J. Exp. 

57: 227-230. 2 reÃs. In English. 

M , 1953, 

CADMIUM 

See: 

1777 

CALCIFEROL 

see 

VITAMINS. D AND D2 

CALCIUM CHLORIDE 

295 Â»Makino, S. and Tanaka, T. THE CYTOLOGICAL EF 

FECTS OF CHEMICALS IN ASCITES SARCOMAS. II. 

SELECTIVE DAMAGE TO TUMOR CELLS BY CALCIUM 

CHLORIDE, ALUMINUM CHLORIDE, AND HYDROGEN 

PEROXIDE. Gann, Tokyo, 1953, 44: 39-46. 

Abstracted in: Chem. Abstr., 1555, 49: 1951g. 

CALCIUM LACTATE 

See: 

2973 

CANDIDA ALBICANS 

see FUNGI 

CAPROIC ACID, 6-AMINO - 

See: 

15 

CARBAMATE,l, 3-DICHLORO-2-ISOPROPYL-N-DIETHYI,- 

296 

Whitehead, R. W. and Lanier, R. R. THE COMBINED 

EFFECT 

X-RAYS 

OF A HALOGENATED URETHAN DERIVATIVE AND 

ON THE GROWTH OF CERTAIN EXPERIMENTAL 

TUMORS. Cancer Res., 1954, 14: 418-422. 

10 refs. 

297 

Arentsen, K. and Hogreffe, G. Bt HANDLING AF 

LEUKAEMI HOS MUS MED URETHAN. [URETHANE 

TREATMENT OF LEUKEMIA IN MICE.] Ugeskr . 

laeger, 1947, 109: 175-7. 5 refs 

298 

Bryan, W. H., Riley, V. T. and Calnan, D. 

ABSENCE OF EFFECT OF URETHANE ON THE LATENT 

PERIOD OF TUMORS INDUCED WITH SUBCUTANEOUS 

INJECTIONS OF THE AGENT OF CHICKEN TUMOR I. 

J. Nat. Cancer Inst ., 1947, 7: 203-206 

Abstracted 

5615b, 

in: Chem. Abstr ..T.947, 41: 

â€”¿ 

299 

Caleff, I. M. SULL'AZIONE DI UNA SOLUZIONE 

S??T5Ã•S;ESESTROLO SÃ¼T""Â«Â»! DEL TOPOLINO E 

DEL RATTO. [ACTION OF A URETHAN-HEXESTROL 

SOLUTION ON MOUSE AND RAT TUMORS.] Boll 

Soc. ital. biol. sper., 1949, 25: 467-468 

Abstracted in: Chem. Abstr., 1951 45: 

6738c . 

300 

IN NORMAL AND LEUKEMIC MICE AND IN RABBITS 

Brit. J. Cancer, 1947, !_:48-59. 32 refs. ' 

301 

Engstrom, R. n., Kirschbaum, A and Mixer 

H. W. EFFECT OF URETHAN ON MOUSE MYELc4 

GENOUS LEUKEMIA. Science, 1947, 105: 255- 

6. Abstracted in: Chem. Abstr T937 41' 

No. Ho. 3216b; 19675. Biol. Abstr., Bait., 1947, â€”¿ TT-' 

302 

GUthert, H. VERGLEICHENDE UNTERSUCHUNGEN ÃœBER 

DIE EINWIRKUNG VON URETHAN UND COLCHICIN AUF 

DEN MAUSEASZITESKREBS. [COMPARATIVE INVES 

TIGATIONS ON THE EFFECT OF URETHANE. AND 

COLCHICINE ON MOUSE ASCITES TUMORS.] Zschr. 

ges. inn. Med., 1948, 3: 625-627. 20 refs. 

303 

uÃ¯,' > DIE EINWIRKUNG VON URETHAN AUF DEN 

MAUSEASCITESTUMOR. [THE EFFECT OF IIBRTHANÃ• 

ON 

1949, 

MOUSE 

85: 

ASCITES 

160-162. 

TUMOR?) 

Absiracteo 

zii. alle 

": ExceÃpii 

f-aTh 

med., SÂ¥ct. 5, 1951, 4: No. 2097. 'The 

authors observed a very temporary decrease 

of the ascites which might explain a short 

prolongation of the survival period. Cytological 

research shoved abnormal mitoses 

which might possibly be the result of a 

cytoplasmic effect. Therapeutic applications 

are of no value." - Excerpta med 

304 

Haddow, A. and Sexton, W. A. INFLUENCE OF 

CARBAJIIC ESTERS (URETHANES) ON EXPERIMENTAL 

ANIMAL TUMORS. Nature, Lond., 

500-503. 25 refs. Abstracted 

1946, 157- 

in: Chem~ 

Abstr., 1946, 40: 44303. A review. 

305 

HÂ°5Ã•^Ã•Â«'Â°' and âereen, E. URETHANE TREAT 

MENT OF LEUKEMIA IN MICE. Acta path, microb 

scand., 1950, 27: 3-8. 6 refs. Abstracted 

in. Excerpta med., Sect 5 19SO 

* Â¿ 

T 

*Â«Â«Â°ltsOoD?a?neaSwÃ•thntrÃnÂ¿pÃ•aÂ¿?f/?"a^""0 

306 umors. 

case of 

ported. 

leukemia in a dog are re 

CARBAMATE, 

See: 

515 1089 

ETHYL 

307 

Kanaki, s. and Fujikawa, H. INHIBITING EFFECTS 

OF VARIOUS COMPOUNDS UPON THE TRANSPLANTATION 

OF THE YOSHIDA SARCOMA. Gann, Tokyo, 1953, 

44: 359-360. In Japanese. The effect of 

urethane and nitrogen mustards on the trans 

planted Yashida sarcoma is described.



22 

CARBAMATE, ETHYL â€”¿ EFFECT ON MALIGNANT 

GROWTH (Continued) 

308 Kanaki, S. and Fujikawa, H. INHIBITING EFFECTS 

OF VARIOUS COMPOUNDS UPON THE YOSHIDA SARCOMA; 

CONTINUED REPORT. Gann, Tokyo, 1954, 45; 


309 Kirschbaum, A. and Lu, C. S. EFFECT OF URE- 

THANE ON THE MATURATION OF LEUKOCYTES OF 

MOUSE MYELOGENOUS LEUKEMIA. 

Exp. Biol., N. Y., 1947, 65: 

Proc. Soc. 

62-63. 5 reÃs. 

Abstracted in: Chem. Abstr., 1947, 41: 

5211f. 

310 LandschUtz, C. and MUller-Dethard, H. H. ZUR 

WIRKUNG DES STHYLURETHANS AM MÃ„USEASCITESTUMOR. 

[THE EFFECT OF ETHYLURETHANE ON AN ASCITES TU 

MOR OF THE HOUSE]. Zschr. Krebsforsch., 1949, 

56- 373-378. 10 reis. Abstracted in: Excerpta 

med., Sect. 5, 1950, 3: Ho. 3509. 

311 Law, L. W. EFFECT OF URETHANE ON A TRANSPLANT- 

ABLE ACUTE LYMPHOID LEUKEMIA. Proc. Soc. Exp. 

Biol., N. Y., 1947, 66: 158-161. Abstracted 

in: Excerpta med., Sect. 5, 1948, !_:No. 1631; 

Biol. Abstr., Bait., 1948, 22: No. 9062. 

312 Law, L. W. URETHANE (ETHYL CARBAMATE) THERAPY 

IN SPONTANEOUS LEUKEMIAS IN MICE. Proc. Nat. 

Acad. So. U. S., 1947, 33: 204-210. 8 refs. 

Abstracted in: Biol. AbsTr., Bait., 1948, 

22: No. 13946; Chem. Abstr., 1947, 41: 6976e. 

313 

Â»Lowinger, S. MEDULLARIS Ã‰S EXTRA-MEDULLARIS 

VÃ•RKÃ‰PZÃ‰SURETHANNAL KEZELT LEUKAEMIAKBAN. 

[MEDULLARY AND EXTRAMEDULLARY HAEMATOPOIESIS 

IN LEUKEMIAS TREATED WITH URETHANE.] Orv. 

Lapja, 1947, 3: 737-742. Abstracted in: 

Excerpta med.7 Sect. 5, 1949, 2: No. 470. 

"...Urethane diminishes extramedullary haematopoiesis 

in myeloid leukaemias, but its thera 

peutic dose does not stop it entirely. Ure 

thane is without any effect on basophils. In 

lymphatic leukaemias the cellulary content of 

the marrow and the spleen does not change sig 

nificantly, but the decrease of the number of 

the granulocytes induced by the use of urethane 

may give rise to complete agranulocytosis. 

-Excerpta med. 

318 

Reimer, E. E. MITOSENSTUDIEN BEI CHRONISCHEN 

MYELOISCHEN LEUKÃ„MIEN UNTER URETHANBEHANDLUNG. 

[MITOSIS STUDIES IN CHRONIC MYELOID LEUKEMIA 

TREATED WITH URETHANE.] Wien. Zschr. inn. 

Hed., 1948, 29: 318-322. 9 refs. 

319 

Rundles, R. W., Dillon, M. L. and Dillon, E. S. 

MULTIPLE MYELOMA. III. EFFECT OF URETHAN 

THERAPY ON PLASMA CELL GROWTH, ABNORMAL SERUM 

PROTEIN COMPONENTS AND BENCE JONES PROTEINURIA. 

J. Clin. Invest., 1950, 29: 1243-1260. 68 refs. 

The relationship of plasma cell proliferation 

to the abnormal serum proteins and to Bence- 

Jones proteinuria in multiple myeloma is studied 

in 11 patients during a period of 3-28 months 

of treatment with ethyl carbamate administered 

in doses of 90-300 grams. "As plasma cell 

growth is inhibited by urethane in multiple 

myeloma, abnormal serum protein components, even 

those generally found not to represent Bence 

Jones proteinemia, are reduced or may virtually 

disappear. This change parallels the reduction 

or disappearance of Bence Jones proteinuria. 

During prolonged continuous administration of 

urethane myeloma cells may become dependent on 

the chemical." 

320 

Shay, H., Harris, C. and Gruenstein, M. THE 

RESPONSE OF TRANSPLANTED CHLORO-LEUKEMIA IN 

THE RAT TO TREATMENT WITH ANTILEUKEMIC DRUGS. 

Blood, Bait., 1956, 11: 167-173. 8 refs. 

321 Skipper, H. E. and Chapman, J. B. CARBAMATES 

IN THE CHEMOTHERAPY OF LEUKEMIA. VI. THE 

INFLUENCE OF URETHAN AND BLOOD ACID-BASE 

EQUILIBRIUM ON MOUSE CHLOROLEUKEMIA 1394. 


Abstracted in: Biol. Abstr., Bait., 1951, 

25: No. 10772. The survival time of mice 

with chloroleukemia was not affected by 

sodium bicarbonate and ammonium chloride 

at levels sufficient to produce alkalosis 

or acidosis. The antiluekemic action of 

urethan was not adversely affected by ad 

ministration of ammonium chloride together 

with urethan. 

314 Mauri, C. and Ninni, M. SUL POTERE LEUCOLITICO 

DEL SIERO DI SANGUE DI LEUCEMICI IN CORSO DI 

TRATTAMENTO CON ETILURETANO. [LEUKOLYTIC 

POTENCY OF THE BLOOD SERUM OF PATIENTS DURING 

ETHYLURETHANE THERAPY.] Boll. Soc. ital. 

biol. sper., 1948, 24: 176-179. 6 refs. 

315 Murphy, J. B. and Sturm, E. THE EFFECT OF URE 

THANE ON LYMPHATIC LEUKEMIA IN RATS. Science, 

1946, 104: 427. 

316 Murphy, J. B. and Sturm, E. THE INHIBITING 

EFFECT OF ETHYLURETHANE ON THE DEVELOPMENT 

OF LYMPHATIC LEUKEMIA IN RATS. Cancer Res., 


Chem. Abstr., 1948, 42: 3080b. 

322 Â«Warren, T. N. FRACTIONATION AND CHEMICAL ANA 

LYSES OF A MALIGNANT MOUSE THYMOMA. Am. J. 

Med., 1948, 4: 459. 

See: 

129 

1057 

2841 

130 

1389 

343 

1911a 

513 

1923 

648 

2128 

EFFECT ON MALIGNANT GROWTH, COUNTERACTION TO 

323 Boyland, E. and Koller, P. C. EFFECTS OF URE- 

THANE ON MITOSIS IN THE WALKER RAT CARCINOMA. 

Brit. J. Cancer, 1954, 8: 677-684. 1 pi. 

See: 

2841 

26 refs. 

317 Parry, H. B. and InnÃ©s, J. R. M. EFFECTS OF 

URETHANE UPON ACUTE LYMPHATIC LEUKAEMIA IN 

A DOG. 

Wash., 

In: APPROACHES TO TUMOR CHEMOTHERAPY. 

AmT Ass. Advance. Sc., 1947, p. 416- 

418. 2 refs.



23 

CARBAMATE, ETHYL â€”¿EFFECT ON MALIGNANT GROWTH, 

ENHANCEMENT OF 

324 

Morelli, E. and Misler, G. AZIONE SINERGICA 

DELL'URETANO E DELLA VITAMINA A. [SYNERGISTIC 

ACTION OF URETHAN AND VITAMIN A.] Farmaco. 

Pavia, 1948, 3: 807-809. Abstracted in: Chem. 

Abstr.,1948, 4"2: 8340h; Excerpta med., Sect. 

2, 1949, 2: NOT 995. 


325 

Albrecht, M. and Boll, I. UNTERSUCHUNGEN ÃœBER 

DIE EINWIRKUNG VON COLCHICIN, ARSENIGER SÃ„URE, 

STICKSTOFFLOST UND AETHYLURETHAN AUF MENSCHLICHES 

KNOCHENMARKIN VITRO. [ACTION OF COLCHICINE, 

ARSENIC ACID, NITROGEN MUSTARDS AND ETHYL URE- 

THANE ON HUMANBONE MARROWIN VITRO.] Aerztl. 

Wschr., 1950, 5: 485-489. 21 refs. 

326 

Baldassarri, R. AZIONE DELL'URETANO ETILICO 

SUL MIDOLLO OSSEO 

OF ETHYL-URETHANE 

COLTIVATO IN VITRO. [ACTION 

ON BONE MARROW CULTIVATED 

IN VITRO.] Oncologia, Roma, 1949. 23: 123- 

130. 

327 

Baliassarri, R. AZIONE DELL'URETANO ETILICO 

SUL MIDOLLO OSSEO COLTIVATO IN VITRO. [ACTION 

OF URETHAN ON TISSUE CULTURES OF BONE MARROW.) 

Boll. Soc. Ital. biol. sper., 1949, 25: 533- 

534. Abstracted in: Excerpta med.,~S"ect. 5, 

1951, 4: No. 1842. 

328 

Bastrup-Madsen, P. ACTION OF MITOTIC POISONS 

IN VITRO. I. EFFECT OF URETHANE ON DIVISION 

OF FIBROBLASTS. Acta path, microb. scand., 

1949, 26: 93-112. 15.refs. 

329 

Battle, H. I. and Hisaoka, K. K. EFFECTS OF 

ETHYL CARBAMATE(URETHANE) ON THE EARLY DEVE 

LOPMENT OF THE TELEOST, BRACHYDANIO RERIO. 

Cancer Res., 1952, !Â£: 334-340. 2 pi. 44 

refs. 

330 

Begemann. H. and Hemmerle, W. DIE MITOSETÃ€TIGKEIT 

DES MENSCHLICHEN KNOCHENMARKS UND IHRE BEEIN 

FLUSSUNG DURCH CYTOSTATISCHE SUBSTANZEN. [MI 

TOTIC ACTIVITY IN HUMAN BONE MARROW AND THE 

INFLUENCE OF CYTOSTATIC AGENTS.] Klin. Wschr 

1949, 2^7: 530-537. 38 refs. Abstracted in: 


331 

Bucher, 0. DIE WIRKUNG VON ATHYLURETHAN AUF 

DIE MITOTISCHE ZELLTEILUNG, UNTERSUCHT AN 

GEWEBEKULTUREN IN VITRO. [THE INFLUENCE OF 

ETHYL CARBAMATE ON CELL DIVISION IN TISSUE 

CULTURE IN VITRO.] Helvet. physiol. pharm. 

acta, 1949, 7: 37-54. 53 refs. Experiments 

with ethyl carbamate in varying Quantities 

and applied at different intervals on coverglass 

cultures of fibrocytes are reported. 

A 0.1-0.5% solution of urethane first caused 

a lengthening of the late metaphases and of 

the anaphases, then an increase of the late 

telophases. with strong concentrations an 

increase of the early metaphases occurred. 

The 10-hour effect of a 1% urethane solution 

caused nuclear pycnosis. 

332 

Candido, R. SULL'AZIONE DELL'ETILURETANO 

SULL'OVARIO DI CONIGLIA. [EFFECT OF ETHYL 

URETHAN ON THE RABBIT OVARY] . Arch ostet 

gin., 1949, 54: 593-604. 18 refs. Abstracted 


333 Cornman, I. INHIBITION OF SEA-URCHIN EGG CLEAVAGE 

BY A SERIES OF SUBSTITUTED CARBAMATES. J. Nat. 

Cancer Inst., 1950, 10: 1123-1138. 38 refs. 

Abstracted in: ExcerpTa med., Sect. 5. 1952, 

5: No. 51. 

334 

Driessens, J. ACTION FRESATRICE DE L'Ã‰THYL- 

URÃ‰THANE SUR LES CULTURES DE FIBROBLASTES 

DE COEUR D'EMBRYON DE POULETS. [INHIBITORY 

EFFECT OF ETHYL URETHANE ON CULTURES OF FIBRO 

BLASTS FROM THE EMBRYONIC CHICK HEART.] 

C. rend. Soc. biol., 1952, 146; 1112-1114. 

Abstracted in: Excerpta med., Sect. 16, 1954. 

No. 1172. 

335 

Dubravsky. K. and OkoliSany, 0., UCINOK PODKOZNÃ‰HO 

APLIKOVANIA ETYLURETHANU U KRALIKOV. [RESULTS 

OF SUBCUTANEOUS ADMINISTRATION OF ETHYLURETHANE 

IN RABBITS.] Cas. lek. cesk., 1948. 87: 134- 

140. 20 reÃs. "Subcutaneous administration 

of ethylurethane in doses of 0.5 g, 6 times 

weekly over a period of 144 days, to healthy 

rabbits, resulted in no changes of the blood 

picture. The thyroid gland, spleen and liver 

also remained unchanged...one case of human 

myeloid leukemia complicated by panhaemophthysis 

is reported...Following urethane treatment, 

necrotic areas appeared in 

blood marrow was 'empty.'" 

the spleen and the 

336 Dury, A. and Robin, E. D. URETHANE-INDUCED 

LYMPHOPENIA IN NORMAL AND ADRENALECTOMIZED 

RATS. Endocrinology, 1948. 42: 320-325. 

13 refs. "Urethan produced a~leucopenia 

and an absolute lymphopenia of similar mag 

nitude in normal intact and adrenalectomized 

rats...the adrenal glands were not involved..." 

337 

Fuhrmann, K. ÃœBER DIE EINWIRKUNG DES URETHANS 

AUF DEN EIERSTOCK DER WEISSEN MAUS. [EFFECT 

OF URETHANE ON THE OVARIES 

Virchows Arch., 1950, 319: 

OF THE 

1-19. 

WHITE MOUSE.] 

Approx. 120 

refs. In daily doses of 0.3-1.0 g per kg of 

weight urethane affected the growth of the 

follicles and caused atrophy of the follicles 

in mice. These effects are reversible upon 

withdrawal of the drug. 

338 

Guyer, M. F. and Claus. P. E. EFFECTS OF URE 

THANE (ETHYL CARBAMATE)ON 

Soc. Exp. Biol., N. Y., 

MITOSIS. 

1947, 64: 

Proc. 

3-5. 

3 refs. 

339 

HarÃ¡szti, A. and Kellner, B. THE EFFECT OF 

ACUTE AND CHRONIC URETHANE TREATMENT ON THE 

RAT. Acta morph. hung., 1955, 5: 191-203. 

50 refs. "A 10% aqueous solution of ure 

thane was administered intraperitoneally 

to 105 rats. Histological tests showed that 

urethane affected chiefly the lymphoid or 

gans, the duodenum and the testicles and 

it reduced the leucocyte count. The effects 

of urethane on both resting and dividing 

cells are less severe than those of colchicine, 

podophyllin or nitrogen mustard." 

340 

Howe, C. 1. and Tedeschi, C. G. EFFECTS OF 

URETHANE ON LIVING TISSUE. Proc. Soc. Exp 

Biol., N. Y., 1949, 71^: 267-270. 9 refs. 

341 

Johnson, F. H. and Gray, D. H. NUCLEI AND 

LARGE BODIES OF LUMINOUS BACTERIA IN RELA 

TION TO SALT CONCENTRATION, OSMOTIC PRESSURE 

TEMPERATURE, AND URETHAN. J. Bact., Bait 


Chem. 5D~str., 1950, 44: 1563g. For influence 

of urethane, see p. BF5-687. 

342 

KerÃ©nyi, N. and RoÃ±a, G. WIRKUNG DES URETHANS 

AUF DIE GLOMERULI UND DAS KAPILLARSYSTEM VER 

SCHIEDENER VERSUCHSTIERE. [THE EFFECT OF 

URETHANE ON THE GLOMERULES AND THE CAPILLARY 

SYSTEM IN VARIOUS EXPERIMENTAL ANIMALS.] 

Acta morph. hung,, 1955, 5: No. 1-2, 85-93 

17 refs.



24 

CARBAMATE, ETHYL â€”¿ EFFECT 


ON NORMAL 

343 Lasnitzki, I. SOME EFFECTS OF URETHANE ON THE 

GROWTH AND MITOSIS OF NORMAL AND MALIGNANT 

CELLS IN VITRO. Brit. J. Cancer, 1949. 3: 

501-509. 4 pi. 25 reÃs. Abstracted in: 

Chem. Abstr., 1950, 44: No. 8498b. "...urethane 

causes a decrease in growth and mitotic 

activity in cultures of normal tissues, 

whereas it stimulates growth and mitotic 

activity in cultures of tumor tissue. It 

is suggested that the surface activity of 

urethane may play a role in the growth 

stimulation of tumour cells." -Survey of 

papers. 

344 Lennert, K. and ligner, G. DIE URETHANWIRKUNG 

AUF DAS BLUT UND DIE BLUTBILDENDEN ORGANE 

DES KANINCHENS. [EFFECT OF URETHANE ON 

BLOOD AND BLOOD-FORMING ORGANS OF THE RABBIT.] 

Frankf. Zschr. Path., 1948, 59: 498-524. 

Bibliography p. 523-524. Abstracted in: 


349 Lobato GuimarÃ¤es, J. ACCÃ„O DA URETANA SOBRE 

O INTESTINO ISOLADO. [THE EFFECT OF URETHANE 

ON THE TREATED INTESTINE.] Arq. Inst. farm., 

Coimbra, 1946-1947, 9: 7-18. 5 pi. The drug 

affects the muscular fiber of the intestine, 

but does not affect nervous parasympathetic 

formations. 

346 Lorenz, W. WEITERE UNTERSUCHUNGEN ÃœBER DIE 

URETHANWIRKUNG AUF DIE MAUSEMILZ MIT BEZIEHUNG 

ZUR KLINIK. [FURTHER STUDIES ON EFFECTS OF 

URETHANE ON THE SPLEEN OF THE MOUSE IN RELA 

TION TO TREATMENT.] Strahlentherapie, 1948, 

77: 375-382. 22 refs. 

347 Lushbaugh, C. C., Green, J. W., Jr. and Storer, 

J. B. HISTOPATHOLOGIC STUDY OF THE MODE OF 

INHIBITION OF CELLULAR PROLIFERATION BY URE- 

THAN:EFFECTOF URETHANON WOUNDHEALING. 

J. Nat. Cancer Inst., 1948, 8: 201-207. 1 pi. 

21 refs. Abstracted in: Chem. Abstr., 1948, 

42: 7442C. 

348 Luther, W. and Lorenz, W. ÃœBER DIE HISTOLO- 

GISCHEN VERÃ„NDERUNGEN DER MÃ„USEMILZ NACH 

RÃ–NTGENGESTRAHLUNG UND URETHANBEHANDLUNG. 

fON THE HISTOLOGICAL CHANGES IN THE SPLEEN 

OF MICE FOLLOWING ROENTGEN IRRADIATION AND 

URETHANE TREATMENT.] Strahlentherapie, 

1947 77: 27-32. Approx. 15 refs. Abstrac 

ted inT-Excerpta med., Sect. 2, 1949, 2: 

No. 3403. 

349 "McMillan, D. B. and Battle, H. I. EFFECTS OF 

ETHYL CARBAMATE (URETHAN) AND RELATED COM 

POUNDS ON EARLY DEVELOPMENTAL PROCESSES OF 

THE LEOPARD FROG, RANA PIPIENS. Cancer 

Res., 1954, 14J 319-323. pi. 14 refs. 

350 Marcolongo, V. L'AZIONE DELL'URETANO ETILICO 

SULLO SVILUPPO DEI FIBROBLASTI NI VITRO. 

[THE EFFECT OF ETHYL URETHANE ON THE DEVELOP 

MENT OF FIBROBLASTS IN VITRO.] Oncologia, 

Roma, 1948, 2Â£: 229-236. 

351 Mauri, C. INFLUENZA DELL'ETILUHETANO SUL QUADRO 

EMATO-MIDOLLARE DI SOGGETTI NORMALI. [INFLUENCE 

OF ETHYLURETHANE ON THE BLOOD AND BONE MARROW 

PICTURE OF NORMAL INDIVIDUALS.] Boll. Soc. ital. 

biol. sper., 1948, 24: 173-176. 6 refs. 

352 Meili, J. DER EINFLUSS DES URETHANS AUF DAS 

NORMALE BLUTBILD. [THE EFFECT OF URETHANE 

ON THE NORMAL BLOOD PICTURE.] 16p. Zurich, 

1948. (Inaug. -Diss. -Zurich). 10 refs. 

353 Mocschlin, S. and Meili, J. EINFLUSS DES URE- 

THANS AUF DAS NORMALE BLUTBILD BEIM MENSCHEN. 

[THE INFLUENCE OF URETHANE ON THE NORMAL 

BLOOD PICTURE IN MAN.] Schweiz, med. Wschr., 


ExcerpÃ¯Ã¯med., Sect. 2, 1948, 1: No. 3773. 

354 Moeschlin, S. and Naef, A. EINFLUSS DES URE- 

THANS AUF DAS BLUTBILD DER LABORATORIUMSTIERE. 

[THE EFFECT OF URETHANE ON THE BLOOD PICTURE 

OF LABORATORY ANIMALS.] Schweiz, med. Wschr., 

1948, 78: 458-462. Approx. 25 refs. 

Naef, A. EINFLUSS DES URETHANS AUF DAS BLUTBILD 

DER LABORATORIUMSTIERE. [EFFECT OF URETHANE 

ON THE BLOOD PICTURE OF LABORATORY ANIMALS.] 

48 p. Zurich, 1949, (Inaug.-Diss., Zurich). 

33 refs. The effects of urethane on the blood 

picture of guinea pigs, rats, rabbits, mice, 

and cats were studied when administered Â¿rally 

in doses of 0.1-1.0 g per kg of weight daily 

over a period up to 80 days. 

356 Pansini, R. CONTRIBUTI SPERIMENTALI SUI VELENI 

ANTIMITOTICI. II. L'INFLUENZA DELL'ETILURE- 

TANO SULLA MORFOGENESI DELLE UOVA DI PARACEN- 

TROTUS LIVIDUS LK, [EXPERIMENTAL STUDIES ON 

ANTIMITOTIC POISONS. II. THE ACTION OF URE 

THANE ON THE MORPHOGENESIS OF THE OVA OF PARA- 

CENTROTUS LIVIDUS LK.] Arch. sc. biol., 

Bologna,. 1951, 35: 339-359. 50 refs. 


5: No. 2387. 

357 |f 

Pipkorn, U. DER EINFLUSS VON URETHAN, HISTAMIN 

UND NOVOKAIN AUF DAS WEISSE BLUTBILD. [THE 

EFFECT OF URETHANE, HISTAMINE AND NOVOCAINE 

ON THE WHITE BLOOD PICTURE.] Med. Klin., 

Beri., 1949, 44: 78-80. Approx. 25 refs. 

358 Rappay G. and Barka, T. PLASMATIC BUDDING IN 

ASCITIC TUMOUR CELLS OF MICE UPON THE ACTION 

OF JANUS GREEN B. Acta morph. hung., 1955, 

5: 379-383. 7 refs. Monoiodo acetic acid 

and urethane are able to prevent plasmatic 

budding caused by Janus green B. 

359 Rosin, A. EFFECT OF URETHANE (ETHYL CARBAMATE) 

ON MITOTIC ACTIVITY IN THE BONE MARROW OF 

NORMAL MICE. Blood, Bait., 1951, 6: 652-660. 

23 refs. 

360Sandk'uhler, S. and Wagner, I. UEBER URETHAN- 

SCHÃ•DEN AN LEUKOZYTEN. [TOXIC EFFECTS OF 

URETHANE ON LEUCOCYTES.] Deut. med. Wschr., 


Index Snalyt. cancer., Par., 1950, 21: No. 753. 

361 

Seiler, D., Schmengler, E. E. and Ferenbach, H. 

ZUR LEUKOCYTENREGULATION UNTER URETHAN. 

[LEUCOCYTE REGULATION DURING URETHANE TREAT 

MENT.] Klin. Wschr., 1949, 27_: 594-596. 


Â«: 7241e. 

362 

3 

An o 

PY OF LEUKEMIA. I. A PROCEDURE FOR SCREENING 

COMPOUNDS FOR LEUKOTOXIC ACTION. Blood, Bait., 

1948, 3: 774-779. 7 refs. 

Tischendorf , W. and Fritze, E. TIEREXPERIMEN 

TELLE UNTERSUCHUNGEN ZUR URETHANWIRKUNG AUF 

DAS BLUT UND DIE BLUTBILDENDEN GEWEBE. [EX- 

PERIMENTAL STUDIES ON THE ACTION OF URETHANE 

ON THE BLOOD AND HEMATOPOIETIC TISSUES.] 



2: No. 2629.



25 

CARBAMATE, ETHYL â€”¿ EFFECT 


See: 

23 

792 

366 

960 

638 

1947 

849 

1981 

787 

2148 

ON NORMAL 

EFFECT ON NORMAL GROWTH, COUNTERACTION TO 

364 

Skipper, H. E. and Scbabel, F. Mâ€ž,Jr. REVERSAL 

OF THE GROWTH INHIBITORY ACTION OF URETHAN BY 

2,6-DIAMINOPURINE. Arch. Biochem.. N. Y., 

1952, 40: 476-478. 16 refs. 

EFFECT ON NORMAL GROWTH, ENHANCEMENT OF 

388 

RÃ¼ge, R. and Rummel, W. BEEINFLUSSUNG DER URE- 

THANHÃ€MOLYSE DURCH SCHWERMETALLE. [EFFECT OF 

HEAVY METALS ON THE HAEMOLYTIC ACTION OF URE- 

THANE.] Arch. exp. Path., Lpz., 1953. 217: 

329-336. 17 refs. 


PROCESSES) 

366 

Abu Jamra, M. and Gomide, Â». BALANCE DE 

L'AZOTE CHEZ LES LEUCÃ‰MIQUES TRAITÃ‰S AVEC 

L'URETHANE. OBSERVATIONS SUR L'Ã‰LIMINA 

TION DES 17-CÃ‰TOSTÃ‰ROÃ•DESET SUR LA MA 

TURATION CELLULAIRE. [NITROGEN BALANCE 

OF LEUKEMIA PATIENTS TREATED WITH URETHANE; 

OBSERVATIONS ON THE ELIMINATION OF 17- 

KETOSTEROIDS AND ON CELL MATURATION.] 

Sang., Par., 1952, 23: 31-44. 7 refs. 

Spanish translationTn: Arq. Clin., Rio, 

1951, 12: 469-488. No consistant effect 

on the nitrogen balance was observed in 

leukemia patients treated with urethane. 

The drug caused an increase in the elimi 

nation of 17-ketosteroids in the urine. 

There was no conclusive evidence that 

urethane produces increased catabolism. 

In 5 of 11 cases urethane caused in 

creased cell maturation. 

367 

Bailey, H. S. and Christian, J. E. DISTRIBUTION 

OF Nl5 IN RAT TISSUES FOLLOWING INTRAPERITO- 

NEAL ADMINISTRATION OF NITROGEN-LABELED URE 

THAN. J. Am. Pharm. Ass. Se. Ed., 1952, 41: 

517-521. 15 refs. 

368 Bazin. S. ETtJDE DE LA FIXATION DE L'URE'THANE 

ET DE LA DIETHYLMALONYLUREE SUR LES ERYTHRO- 

CYTES. [A STUDY OF THE FIXATION OF URETHANE 

AND DIETHYLMALONYLUREA ON THE ERYTHROCYTES.1 

C. rend. Soc. biol., 1949, 143: 345-346. 

6 refs. Abstracted in: Excerpta med., Sect. 

2, 1950, 3: No. 3365. 

369 

Becker, V. and Rauschke, J. IN VITRO-UNTERSU- 

CHUNGEN VON GIFTWIRKUNGEN AUF FERMENTSYSTEME 

DER ZELLATMUNG. [IN VITRO STUDIES ON EFFECTS 

OF POISONS ON ENZYME SYSTEMS OF CELLULAR 

RESPIRATION.] 

117: 373-383. 

Zschr. ges. exper. Med., 1951, 

35 refs. Poisons of carbohydrate 

metabolism (NaF, oxalate, citrate, 

monobromoacetate, urethane, malonate and 

potassium cyanide) as well as alloxan, allyl 

formiate and glyoxal were investigated. 

370 Beickert, A. EXPERIMENTELLE UNTERSUCHUNGEN 'ÃœBER 

DIE UMSETZUNG DES URETHANS IM ORGANISMUS [EX 

PERIMENTAL STUDY OF THE TRANSFORMATION OF URE 

THANE IN THE ORGANISM.] Zschr. ges. inn Med 


Excerpta med., Sect. 2, 1952, 5: No. 3392 

374 

371 

Beickert, A. TIEREXPERIMENTELLE UNTERSUCHUNGEN 

ÃœBER DASSCHICKSAL DESURETHANS IMORGANISMUS. 

[EXPERIMENTAL STUDIESONTHEFATEOFURETHANE 

IN THE ORGANISM.] Zschr. ges. exp. Med., 


Chem. AlSstr., 1951, 45: No. 5325Ã•. 

372 

Beickert, A. ÃœBER DEN URETHANUMSATZ IM TUMOR- 

KRANKEN ORGANISMUS. 

IN THE TUMOR-BEARING 

[METABOLISM 

ORGANISM.] 

OF URETHANE 

Zschr. ges. 

exp. Med., 1952, 119: 419-425. 7 refs. 

Abstracted in: ExceTpta med., Sect. 16, 1954, 

No. 111. 

373 

DEL CIANATO E DELL'URETANO SULLA SUCCINO- 

DEIDRASI. [ENZYMATIC INTERFERENCE OF ANTI- 

MITOTIC SUBSTANCES. 2. THE EFFECT OF CYANATE 

AND URETHANE ON THE SUCCINIC DEHYDROGENASE 1 

Tumori, Milano, 1951, 37: 361-370. 15 refs 

Urethane had a less pronounced inhibiting 

effect on succinic dehydrogenase than did 

cyanate. 

Black, M. M. and Speer, F. D. EFFECTS OF CAN 

CER CHEMOTHERAPEUTIC AGENTS ON DEHYDROGENASE 

ACTIVITY OF HUMAN CANCER TISSUE IN VITRO 

Am. J. Clin. Path., 1953, 23: 218-227. i pi 

6 refs. "(a) There is a decided biochemical 

variability of cancer tissue from different 

patients having the same type of cancer; (b) 

there is no apparent correlation between the 

intensity of the in vitro endogenous dehydro 

genase activity of the cancer tissue and its 

clinical behaviour; (c) the in-vitro effect 

of urethan on the dehydrogenase activity of 

cancer tissue appears to parallel the radiosensitivity 

of the tissue; (d) combinations 

of chemotherapeutic agents sometimes enhance 

the in-vitro inhibitory effect." 

375 

ON THE 

. 

Inst., 1954, 14: 1147-1158. 6 refÂ¿ 

^St^Ã•edI.Ã•nT~ExCerpta med" Sect- 16> 1954, 

Nn' Â«â„¢! EÃ"rPta med-. Sect. 5, 1954 7: ' 

No 2820 "Measurements were made of thÃëffect 

of urethan, TEM and aminopterin 

singly and in combination, on the in-vitro 

dehydrogenase activity of the cancer tissues 

An attempt was also made to correlate the 

in-vitro effects of these agents with their 

clinical cancer chemotherapeutic effects 

The data indicate that there is positive 

correlation between the in-vitro effects of 

*Mrt" tested and 

376 

Sodine, J. H. and Fitzgerald, L. R. THE AC 

TION OF ETHYL CARBAMATE (URETHANE) ON THE 

RESPIRATION OF ACTIVE AND BLOCKED EMBRYONIC 

CELLS. 

15 refs. 

Physiol. Zool., 1948, 21- 303-308 

â€”¿ 

377 

Bodine, J. H. and Fitzgerald 

CARBAMATE) 

M 

UPON THE OXYGEN UPTAKE OF 

NETHYL 

EMBRY 

ONIC CELLS. Physiol. Zool., 1949, 22: 283- 

294. 22 refs. â€”¿ 

378 

Boy land, E. and Rhoden, E. THE DISTRIBUTION 

OF URETHANE IN ANIMAÂ¿TISSUES, AS DETERM?NED 

BY A MICRODIFFUSION METHOD, AND THE EFFECT 

OF URETHANE TREATMENT ON ENZYMES Biochem 

J., Lend., 1949, 44: 528-531 17 refs



26 

CARBAMATE, ETHYL â€”¿METABOLISM (INCLUDING 

EFFECTS ON METABOLIC PROCESSES) (Continued) 

379 Boyland, E. and Williams-Ashman, H. G. THE 

INFLUENCE OF URETHANES ON THE ENZYMIC ACTI 

VITY OF NORMAL AND MALIGNANT TISSUES. Acta 

UniÃ³ internat, cancr., Louvain, 1951, 7: 

432-435. 8 refs. 

380 Bryan, C E., Skipper, B. E. and White, L. Jr. 

CARBAMATES IN THE CHEMOTHERAPY OF LEUCEMIA. 

IV THE DISTRIBUTION OF RADIOACTIVITY IN 

TISSUES OF MICE FOLLOWING INJECTION OF CAR- 

BONYL-LABELED URETHANE. J. Biol. Chem., 1949, 

177- 941-950. 8 refs. Abstracted in: Chem. 

Abstr , 1949, 43: No. 3917g; Biol. Abstr., 

Bait., 1949, 2J7 No. 23824. 

381 Carbonell de Jaffe. M. CONTRIBUCIÃ“N AL ESTUDIO 

DEL MODO DE ACCIÃ“N DE LOS NARCÃ“TICOS. EFECTO 

DEL URETANO SOBRE LOS FERMENTOS. [THE MODE 

OF ACTION OF HYPNOTIC DRUGS. THE EFFECT OF 

URETHANE ON ENZYMES.] Rev. san., Caracas, 

1947, 12Â¡:545-564. 9 refs. 

382 Dicker, S. E. THE RENAL EFFECTS OF URETHAN AND 

COLCHICINE IN ADULT RATS. Brit. J. Pharm. 


Chem. Sbstr., 1951, 45:8656f. 

URETHANE TREATMENT ON CHICKEN BONE MARROW 

ENZYMES. Proc. Soc. Exp. Biol., N. Y., 1950, 

74- 776-777. 6 refs. Abstracted in: Excerpta 

5e"d., Sect. 2, 1951, 4: No. 3179. 

384 Ellis F. W. and West, P. M. SENSITIVITY OF 

SERUM ENZYME INHIBITORS TO A VARIETY OF 

CANCER CHEMOTHERAPEUTIC AGENTS. J. Clin. 

Invest., 1951, 30: 547-557. 14 refs. 

Fellinger, K. and Schmid, J. URETHAN UND LEU- 

KOZYTENATMUNG. [URETHANE AND RESPIRATION OF 

LEUKOCYTES.] Wien. Zschr. inn. Med., Ia4af 

29: 245-253. 30 refs. 

386 ~ 

Ferrarlo, E. IL COMPORTAMENTO DEL METABOLISMO 

DI BASE E DELLA VELOCITA DI ERITROSEDIMENTA 

ZIONE NELLE LEUCEMIE CRONICHE TRATTATE CON 

ETILURETANO. [BASAL METABOLISM AND ERYTHRO- 

CYTE SEDIMENTATION RATE IN CHRONIC LEUKEMIA 

TREATED WITH ETHYLURETHANE.] Arch. sci. med., 

1949, 87: 225-258. tab. Approx. 150 refs. 

Florijn, E., Gruber, M., Leijnse, B. and Huisman, 

T H J THE INHIBITION OF TISSUE RESPIRATION 

Im ALCOHOLÃ•C FERMENTATION AT DIFFERENT CATA- 

BOLIC LEVELS BY ETHYL CARBAMATE (URETHAN) AND 

ARSENITE. Biochim. biophys. acta, Amst., 


Chem. Abstr., 1950, 44: No. 10755Ã•. 

OQO 

Fritze E DER PURINSTOFFWECHSEL BEI LEUKÃ„MIEN 

UNTER URETHANBEHANDLUNG. [PURINE METABOLISM 

IN URETHANE-TREATED LEUKEMIA] . Klin. Wschr . , 

1949, 27: 366-369. Approx. 35 refs. Ure 

thane Treatment caused an increased urinary 

excretion of uric acid in chronic myelogenous 

and lymphogenous leukemia. 

389 â€”¿ > A and Gomide, W. BALANCE DE L'AZOTE 

Z DES LEUCÃ‰MIQUESTRAITÃ‰S_AVECIJURjTHANE ; 

SUR 

STOSTEROIDSANDO 

Sang, Par., 1952, 23: 31-44. 

39Â° 

'. A and Gomide, W. 

o CEÂ«. [NITROGEN BALANCE IN 

LEUKEMIA TREATED WITH URETHANE; OBSERVATIONS 

ON 17-KETOSTEROID ELIMINATION AND ON CELL 

MATURATION.] Arq. clin., Rio, 1951, 12: 4> 

488. 2 tab. 7 refs. 

391 

Kamakura K. Shimakoshi, Y., Morikawa, A. and 

Uyama K. STIMULATING EFFECTS OF ETHYLURE- 

THAN ON THE METABOLISM OF RATS, AND THE CON 

SIDERATION OF THE EFFECTS WITH SPECIAL RE 

FERENCES TO THE RADIOMIMETIC ACTION. Nara 

Igaku zassi, 1954, 5: 49-54. 

39Krieg E. NUCLEALSTUDIEN IM ANSCHLUSS AN EX 

PERIMENTELLE UNTERSUCHUNGEN ÃœBER URETHAN AN 

DER WEISSEN RATTE. [NUCLEUS STUDIES CON 

DUCTED IN URETHANE EXPERIMENTS ON THE WHITE 

RAT ] 29 1. 1949. (Inaug .-Diss ., Mainz). 

29 refs. Typewritten. Urethane is shown 

to act upon the nuclear metabolism. Mice 

treated repeatedly with urethane showed re 

activation of the latent Bartonella mÃ»ris 

ratti virus infection. 

OQO 

Lea, A. J. THE EFFECT OF URETHANES AND DI (2- 

CHLOROETHYL)METHYLAMINE HYDROCHLRIDE ON THE 

AUTOXIDATION OF DOPA. Brit. J. Cancer, 1950, 

4: 341-346. 2 refs. 

394 McKinney, G. R. THE ACTION OF VARIOUS DRUGS ON 

CERTAIN PHASES OF IN VITRO ANABOLISM. J. 

Pharmacol., 1950, 100: 45-50. 7 refs. 


4: No. 4268; Chem. Abstr., 1951, 45j 265e. 

39Miller G L., Brown, C. E., Miller, E. E. and 

EiteÃmaA Ãˆ. S. AN ELECTROPHORETIC STUDY ON 

BDÃ¤ ORIGIN OF THE ABNORMAL PLASMA PROTEINS 

IN MULTIPLE MYELOMA. Cancer Res., 1952, lÂ¿. 

716-719. 

396 ,, , â€ž¿Jr Hutchison, O. S., Skipper, 

3 refs. Abstracted in: "f--^^949 

43- 9251b; Excerpta med., Sect. 5, 

Bo. 413. 

397 Rosenthal, M. C. and Saunders, R. H., Jr. 

BLOOD URETHAN LEVELS ACHIEVED WITH ENTERIC- 

COATED TABLETS. Proc. Soc. Exp. Biol., N. Y., 

1950, 7J5: 173-174. 5 refs. 

39R8uppert, F. ALKALINE PHOSPHAT ASE IN PHARMACYTOMA 

AND THE EFFECT OF URETHANE. Zschr. klin. Med., 

1951 148: 468-472. Abstracted in: Chem. Abstr., 

1954, 4TTT 5331b. 

3"shimakoshi, Y. QUESTION OF THE URETHANE INHIBI 

TION OF DEHYDROGENASES. Nippon seirigaku 

tassi 1953 15: 622-626. 11 refs. In Japa- 

SS.' ingÃ¯islPsummary. Abstracted in: Chem. 

Abstr., 1954, 48: 5377ÃŒ. 

4Â°Sibley, J. A. and Lehninger, A. L. Â«-DOLASE 

IN THE SERUM AND TISSUES OF TUMOR-BEARING 

ANIMALS. J. Nat. Cancer Inst., 1949, W. 

303-309. 7 refs. 

4Â°ikinoer H E INVESTIGATIONS ON THE MECHANISM 

Â»"SÃ Ã•ÃœTILEUKEMICACTION OF URETHAN EMPLOYING 

CARBON 14 COMPOUNDS. Texas 

1950 8: 543-550. 11 refs. 

Rep. Biol. M. , 


Chem: Abstr., 1952, 46: 11425a; 

Bait., 1951, 25: No.~Z0485. 

Biol. Abstr.,



27 

CARBAMATE, ETHYL â€”¿METABOLISM (INCLUDING 

EFFECTS ON METABOLIC PROCESSES) (Continued) 

402 

Skipper, H. E., Bennett, L. L., Jr., Bryan, 

C. E., White, L., Jr., Newton, M. A. and 

Simpson, L. CARBAHATESIN THE CHEMOTHERAPY 

OF LEUKEMIA. VIII. OVER-ALL TRACER STUDIES 

ON CARBONYL-LABELEDURETHAN, METHYLENE-LABELED 

URETHAN, AND METHYLENE-LABELEDETHYL ALCOHOL. 


Abstracted in: Chem. Abstr., 1951, 45: 8655d 

See 

816 

2213 

822 

2394 

1463 

2718 


1828 2208 

403 

Beickert, A. and Jorke. D. EXPERIMENTELLE UNTER 

SUCHUNGEN ZUM WIRKUNGSMECHANISMUS DES URETHANS. 

[EXPERIMENTAL STUDY OF THE MECHANISM OF ACTION 

OF URETHANE.] 

954, 960. 47 

Zschr. ges. inn. Hed., 1952, 7: 

refs. Abstracted in: Excerpta" 

med., Sect. 16, 1954, No. 562; Chem. Abstr., 

1953, 47: No. 10699d. 

404 

Beickert. A. ÃœBER DIE AFFINITÃ„T DES URETHANS 

ZU VERSCHIEDENEN ZELLFORMEN DES NORMALEN 

UND LEUKÃ„MISCHEN BLUTES. [AFFINITY OF URE 

THANE FOR SEVERAL TYPES OF CELLS IN NORMAL 

AND LEUKEMIC 

Beri., 1950, 

BLOOD.] Arch. 

210: 473-478. 

exp. Path. 

12 refs. ' 

405 

BÃ¼cher,,O. ZUR WIRKUNG VON URETHAN AUF GEWEBE 

KULTUREN IN VITRO. [ON THE INFLUENCE OF URE 

THANE ON TISSUE CULTURES IN VITRO.] Schweiz, 

ned. Wschr., 1947, 77: 1229-1230. Abstracted 

in: Excerpta med., Sect. 5, 1948, Ij No. 722. 

406 

Feher. L. VIZSGÃ‚LATOK AZ URETHAN HATÃ„SMECHANIZ- 

MUSAROL KRONIKUS MYELOID LEUKAEMIÃ‚BAN. fIN 

VESTIGATIONS INTO THE MECHANISM OF ACTION OF 

URETHANE IN MYELOID LEUKEMIA.] 

1948, 89: No. 10-11, 175-176. 

Orv. hetilap, 

6 refs. 

Abstracted in: Excerpta med., 

2: No. 4755. "The metabolism 

Sect. 2, 1949, 

of uric acid 

Â¡Turingadministration of urethane in five 

leukemic 

confined 

patients was 

to the white 

investigated...effect 

cells...Uric acid 

excretion is not proportional to the decrease 

of the white cells..." -Excerpta med. 

407 

Fochem, K., Reimer, E. and Schmid, J. EINFLUSS 

DER RONTGENSTRAHLEN AUF DIE URETHANWIRKUNG. 

[EFFECT OF ROENTGEN RAYS ON THE ACTION OF 

URETHANE]. Wien. Zschr. inn. Med., 1951, 32- 

31-36. 22 refs. 

408 

Green, J. w. Jr. and Lushbaugh, C. C. HISTO- 

PATHOLOGIC STUDY OF THE MODE OF INHIBITION 

OF CELLULAR PROLIFERATION BY URETHANE: EF 

FECT OF URETHANE ON WALKER RAT CARCINOMA 

256. Cancer Res., 1949, 9: 199-209. 28 

refs. Abstracted in: BioT. Abstr., Bait., 

1951, 25: No. 13773. Urethane was shown 

to inhlTjit cellular proliferation in part 

by nutritional debilitation of the animal. 

The drug does not arrest mitosis but causes 

an increase in the number of probably fatal 

abnormal mitoses in the malignant cells. 

409 Kelemen, E. L'URETHANE. LE MÃ‰CANISME D'ACTION 

DES NOUVEAUX DÃ‰RIVÃ‰SCARBAMIDÃ‰S EMPLOYES EN 

THERAPEUTIQUE. [URETHANE. THE MECHANISM OF 

ACTION OF THE NEW CARBAMIDE DERIVATIVES USED 

THERAPEUTICALLY.] Sang, Par., 1948, 19: 50- 

56. 35 refs. Abstracted in: Excerpta med.. 

Sect. 5, 1949, 2: No. 1473. 

410 

Lande, A. UEBER DEN HISTOCHEMISCHEN NACHWEIS 

VON KEHNVSRÃ„NDERUNGENAN BLUTZELLEN DURCH 

URETHAN UND SEINEN WIRKUNGSMECHANISMUS BEI 

BEHANDLUNG MYELO-LYMPHATISCHER ERKRANKUNGEN. 

[HISTOCHEMICAL DEMONSTRATION OF NUCLEAR 

CHANGES CAUSED BY URETHANE AND ITS MODE OF 

ACTION IN THE TREATMENT OF MYELO-LYMPHATIC 

DISEASES.] 38 1. MÃ¼nchen, 1951. (Inaug.- 

Diss., MUnchen) 14 refs. 

411 

Lelbetseder, F. and Kwerch, H. UBETHANWIHKUNG 

UND VEGETATIVES NERVENSYSTEM. [ACTION Of 

URETHANE AND THE AUTONOMIC NERVOUS SYSTEM.] 

Zschr. klin. Med., 1951, 148: 180-190. 35 

refs. 

1952, 

Abstracted in: Excerpta med.t Sect. 

5: No. 2275. "A study on the action 

2, 

of ureÃ‡han on the blood and the haemopoietic 

organs in cats showed that this drug may pro 

duce agranulocytosis and aplasia of the bone 

marrow and lymphatic tissue. When di hydroergotamine 

or atropine was given simultaneous 

ly the appearance of agranulocytosis was mark 

edly accelerated. When it was combined with 

atropine, the lymph nodes and spleen showed 

a reticulosis with epithelioid-like cells 

and giant cells. It is concluded that urethan 

does not only act directly on the cell, 

but also via the central and the autonomie 

nervous systems on the regulation 

haemopoiesis." - Excerpta med. 

of the 

412 

Lennert, K. ÃœBER MORPHOLOGIE UND MECHANISMUS 

DER URETHANWIRKUNG. [MORPHOLOGY AND MECHANISM 

OF URETHANE.] Klin. Wschr., 1948, 26: 735- 

736. 

413 

r.AÂ». 

GEN MIT URETHAN. 

EXPERIMENTELLE 

[NEW EXPERIMENTAL 

ERFAHRUN 

STUDIES 

ON EFFECTS OF URETHANE]. Fol. haemat., Lpz , 

1951, 70: 78-81. 

414 

Heythaler, F. 

MECHANISMUS 

and Handel, F. WIRKUNG UND 

DES â€¢¿ATHYLURETHANS.[EFFECTS 

WIRKUNGS 

AND 

MECHANISM OF ACTION OF ETHYL URETHANE.] Verh. 

Deut. Ges. inn. Med., 1949, 55: 406-408. 

415 

Moeschlin, S. KLINISCHE UND EXPERIMENTELLE 

UNTERSUCHUNGEN ÃœBER DEN WIRKUNGSMECHANISMUS 

DES URETHANS. [CLINICAL AND EXPERIMENTAL 

INVESTIGATIONS OF THE MECHANISM OF ACTION 

OF 

1: 

URETHANE.] Acta haemat., Basel, 1948, 

225-247. Bibliography: p. 246-247. 


9263d. 

416 

Â«oeschlin, S. RECHERCHES CLINIQUES ET EXPÃ‰RI 

MENTALES SUR LE MECANISME D'ACTION DE LtURÃŽ- 

THANE. [CLINICAL AND EXPERIMENTAL INVESTI 

GATIONS ON THE MECHANISM OF ACTION OF URE 

THANE.] Sang, Par., 1948, lj): 543-549. 

6 refs. Abstracted 

44: 7561. "Urethan 

in: Chem. Abstr., 1950, 

acts directly or indirect 

ly on the cellular proliferation by inhibi 

ting mitosis. The inhibition seems to bear 

on the enzyme system required for multipli 

cation. Urethan 

the synthesis of 

probably does not 

nucleoprotelns." 

affect 

-Chem. 

Abstr. 

417 

Moeschlin, S. WIRKUNGSMECHANISMUS DES URETHANS 

BEI LEUKÃ„MIEN. [MODE OF ACTION OF URETHANE 

IN 

195-196. 

LEUKAEMIA.] 

2 refs. 

Experientia, 

Abstracted 

Basel, 

in: Excerpta" 

1947, 3: 

med., Sect. 2, 1948, Â¿: No. 3242. 

418 

Moeschlin, S. ZUM WIRKUNGSMECHANISMUS DES URE 

THANS BEI LEUKÃ„MIEN. [THE MODE OF ACTION OF 

URETHANE IN LEUKAEMIA.] Helvet. med. acta, 


Excerpta med., Sect. 5, 1948, 1_:No. 408.



28 

CARBAMATE, 

(Continued) 

ETHYL â€”¿MODE OF ACTION 

419 

Schmid, J. BEITRAG ZDH WIRKUNGSMECHANISMUS DES 

URETHAN. [STUDY ON THE MECHANISM OF ACTION 

OF UHETHANE.] Wien. Zschr. inn. Med., 1948, 

29: 389-397. 16 refs. , 

420 Schmid, W. and Kunz, W. WIRKUNGSUNTERSCHIEDE 

ZWISCHEN URETHANEN UND ANDEREN NARKOTICIS AM 

ZELLSTOFFWECHSEL VON HEFE UND ASCITESTUMOR. 

[DIFFERENCES IN MODE OF ACTION OF URETHANE 

AND OTHER NARCOTICS ON CELL METABOLISM OF 

YEAST AND ASCITES TUMOR.] Arch. exp. Path., 

Beri., 1953, 218: 100. 

421 

Schulze, E. URETHAN, THERAPEUTISCHE VERWENDUNG 

UND MECHANISMUS SEINER WIRKUNG. [URETHANE, 

THERAPEUTIC USE AND MECHANISM OF ACTION.] 

Pharmazie, Beri., 1949, 4: 118-122. 

See 

23 133 323 425 454 

498PHARMACOLOGICAL 

1030 

AND PHYSIOLOGICAL EFFECTS 

422 Cruz, W. 0. and Moussatche, H. ACUTE THROMBO- 

CYTOPENIA INDUCED IN DOGS BY ADMINISTRATION 

OF URETHANE (ETHYL-CARBAMATE) . Blood, Bait., 



423 Cruz, W. 0. and Silva, E. M. da. CONTRIBUTION 

ON THE THROMBOCYTOPENIC ACTION OF URETHANE 

IN DOGS. Brit. J. Pharm., 1949, 4: 132-134. 

9 refs. 

424 Heilmeyer, L. KLINIK UND PHARMAKOLOGIE DES 

URETHANS UND ANDERER CYTOSTATISCHER STOFFE. 

[CLINICAL AND PHARMACOLOGICAL STUDIES OF 

UHETHANE AND OTHER CYTOSTATIC DRUGS.] 120 p. 

Stuttgart, Wissenschaftliche Verlagsgesell 

schaft, 1948. (Beihefte zur Medizinischen 

Monatsschrift. Heft. 4). 268 refs. 

425Hirscher, H. and Billerbeck, K. 'ÃœBERPATHOL.- 

ANATOMISCHE BEOBACHTUNGEN UND PHAGOZYTOSE- 

ERSCHEINUNGEN AN URETHAN BEHANDELTEM MULTI 

PLEM MYELOM. [MORBID ANATOMY AND PHAGOCY 

TOSIS IN MULTIPLE MYELOMA TREATED WITH 

URETHANE.] Aerztl. Wschr., 1950, 5: 239- 

243. 28 refs. Abstracted in: Excerpta 

ned., Sect. 5, 1951, 4: No. 2192. "The 

changes indicate that urethan causes dis 

turbances in the fermentation mechanism of 

the cells, especially in the so-called 

yellow oxidation ferments system. Findings 

in the bone marrow, e.g. phagocytosis in 

the plasmocytoma cells, indicate that tu 

mour cells possibly originate from the 

large lymphoid reticulum cells of the bone 

marrow." -Excerpta med. 

436 Hirscher, H. and Laur, 0. MORPHOLOGISCHE 

VERÃ„NDERUNGEN AN PLASMOZYTOMZELLEN UNTER 

URETHANWIRKUNG, ZUGLEICH EIN BEITRAG ZUR 

FRAGE DER PARAPROTEINE. [MORPHOLOGICAL 

CHANGES OF THE MYELOMA CELLS DUE TO THE 

ACTION OF URETHANE. A CONTRIBUTION TO THE 

QUESTION OF PARAPROTEINS.] Zschr. ges. 

inn. Med., 1950, 5: 641-645. 47 refs. 


4: No. 2521. 

427 

Klima, R. and Wengraf, G. ÃœBER DIE EINWIRKUNG 

VON URETHAN UND ANDEREN SCHLAFMITTELN AUF 

DIE ZENTRAL NERVÃ–SE BLUTSTEUERUNG BEI BLUT 

KRANKHEITEN. [THE EFFECT OF URETHANE AND 

OTHER SOPORIFICS ON THE REGULATION OF THE 

BLOOD BY THE CENTRAL NERVOUS SYSTEM IN 

DISEASES OF THE BLOOD.] Wien, 

1949. 99: 503-505. Abstracted 

med. Wsohr., 

in: Excerpta 

med., Sect. 5, 1950, 3: No. 3386. 

428 

Lennert, K. DIE MORPHOLOGIE DER URETHANWIRKUNG 

BEI LEUKÃ„MIEN, MALIGNEN TUMOREN DES LYMPHA 

TISCHEN SYSTEMS UND DER LYMPHOGRANULOMATOSE. 

[MORPHOLOGICAL EFFECTS OF URETHANE IN LEUKE 

MIA, MALIGNANT NEOPLASMS OF THE 

SYSTEM AND HODGKIN'S DISEASE.] 

LYMPHATIC 

Frankf. Zschr. 

Path., 1950, 61: 339-370. 43 refs. Abstract 

ed in: ExcerptiT med., Sect. 5, 1951, 4: No. 

495. 

429 

Linke, A. and Ulmer, W. ÃœBER DEN EINFLUSS DER 

BEHANDLUNG MIT XTHYLURETHAN 

AUF DIE PHAGCCYTOSEFAHIGKEIT 

UND STICKSTOFFLOST 

MENSCHLICHER LEU- 

KOCYTEN. [EFFECT OF TREATMENT WITH ETHYL URE 

THANE AND NITROGEN MUSTARD ON THE PHAGOCYTIC 

ACTIVITY OF HUMAN LEUCOCYTES.] Klin Wschr., 

1952, 30: 273-277. 20 refs. Leucocytes 

from pÃ¤Tients under treatment with urethane 

and/or nitrogen mustard do not show a decrease 

in their phagocytic activity. 

430 

Linke, A. and Ulmer, W. DIE WIRKUNG VON XTHYL 

URETHAN AUF DIE PHAGOCYTOSEFÃ„HIGKEIT MENSCHLI 

CHER LEUKOCYTEN IN VITRO. [EFFECT OF ETHYL 

URETHANE ON THE PHAGOCYTIC ACTION OF HUMAN 

LEUCOCYTES IN VITRO.] Klin. Wschr., 1951, 

29: 471-473. 17 refs. Ethylurethane inhibTts 

phagocytosis but does not disturb the 

process in therapeutic quantities. 

431 Masshoff, W., Heinzel, W., Rom, G. D. von and 

Siess, M. EXPERIMENTELLE UNTERSUCHUNGEN ÃœBER 

DIE WIRKUNG VON URETHAN AUF PHAGOCYTOSE, SPEI 

CHERUNG UND ENTZÃœNDUNG. [EXPERIMENTAL STUDIES 

ON THE EFFECT OF URETHANE ON PHAGOCYTOSIS, 

STORAGE, AND INFLAMMATION.] Klin. Wschr., 

1948, 26: 397-400. 13 refs. 

432 Osgood, E. E. and Chu, I. T. THE EFFECT OF 

URETHANE ON THE NUCLEAR MORPHOLOGY OF CELLS 

OF THE GRANULOCYTE SERIES AS OBSERVED IN 

MARROW CULTURES AND LEUKEMIC BLOOD. Blood, 

Bait., 1948, 3: 911-917. 17 refs. Also in: 

Sympos. HematT, N. Y., 1949, 598-604. 

43fandkUhler, S. DAS VERHALTEN DER BLUTPHAGOCYTEN 

UNTER CHEMOTHERAPEUTISCHEN KUREN. [THE BE 

HAVIOR OF THE BLOOD PHAGOCYTES DURING CHEMO 

THERAPY.] Sang, Par., 1950, 21: 400-404. 

See: 

386 3199 

SYNERGISTIC ACTION 

434 'Zushbaugh, C. C. and Storer, J. B. SYNERGISTIC 

NECROTIZING ACTION OF URETHANE AND CHLOROFORM. 

Arch. Path., Chic., 1948, 45: 494-502. 11 refs. 

Urethane and chloroform are additively synereistic 

and when given together even in sublethal 

amounts may cause fatal hepatic injury. Three 

case histories and experimental work with rabbits 

in which the two compounds were used as treat 

ment are reported.



CARBAMATE, 

(Continued) 

ETHYL â€”¿ SYNERGISTIC ACTION 

435 Skipper, H. E. CARBAMATES IN THE CHEMOTHERAPY 

OF LEUKEMIA. V. OBSERVATION OF A POSSIBLE 

ANTILEUKEMIC SYNERGISM BETWEEN URETHANE AND 

METHYL-BIS (? -CHLOROETHYL)AMINE. Cancer, 

N. Y., 1949, 2: 475-479. 24 rets. 

See: 

3056 

THERAPY 

436 Aas. K. MYELOMATOSIS WITH NORMAL SERUM-PROTEIN 

VALUES, TREATED WITH URETHAN. Acta med. 

scand., 1949, 135: 426-438. 35 refs. Abstract 

ed in: Chem. AEsTr., 1950, 4Â£: No. 3129Ã•. 

437 

Ajamil, L. F. and Fuentes-Ferrer . J. J. 

URETANO Y CANCER PROSTATICO. [URETHANE AND 

CANCER OF THE PROSTATE]. Bol. Liga cancer, 

Habana, 1949, 24: 3-9. 12 refs. 

43Â« 

Althoff, H. ZUR URETHANBEHANDLUNGDER CHRO 

NISCHEN MYELOISCHEN LEUKÃ„MIE IM KINDESALTER. 

[URETHANE TREATMENT OF CHRONIC MYELOID LEU 

KEMIA IN CHILDHOOD.] Mschr. Kindern., 1951, 


A~6str., 1952, 46: 3657a. 

439 

Alwall, N. URETHANE IN MULTIPLE MYELOMA 1. 

FINAL REPORT OF A CASE TREATED MORE THAN FOUR 

YEARS WITH URETHANE. Acta med. scand., 1952, 

144: 114-118. 

440 . 

Amon, A. DIE BEHANDLUNG DES RETOTHELSARKOM 

MIT URETHAN. [URETHANE TREATMENT OF THE 

RETÃ•CULO SARCOMA]. 35 1. 1948. (Inaug.- 

Diss., MUnchen) . 29 refs. Typewritten. 

Review. 

441 

Anglesio, D. RELAZIONE SULLA CASISTICA DI 

PAZIENTI TRATTATI CON URETANO E CON CLORO- 

AZO-IPRITE. [CASE REPORTS OF PATIENTS 

TREATED WITH URETHANE AND WITH NITROGEN 

MUSTARD]. Minerva med., Tor , 1949, 40- 

pt. 2, 314-315. 

442 

Arsenijevic, li., RadojÃ¯ic, B. and Antic, M. 

HRONICNE MIJELOZE LECENE URETANOM. [CHRONIC 

MYELOSIS TREATED WITH URETHANE.] Voj . San. 

pregi., Beogr., 1953, 10: 130-5. 8 refs. 

Urethane in doses of 3î g. over a period 

of five weeks, was administered per os to 

five patients. In three cases without any 

previous treatment complete clinical and 

hematological remission ensued. Remissions 

lasted up to 15 months when urethane, in 

daily doses of 2 g at least twice a week, 

was given following an intense initial 

treatment with the drug. 

Ayrea, O. DAS LEUKOCITEMIAS. [LEUKEMIAS] 

Impr. med.. Rio, 1952, 28: 29-33. Abstracted 

in: Leukemia Abstr., 1957, 1^:No. 245. "Ci 

tations from several authors on leukemia are 

followed by a report of one case. In a 21- 

year-old woman, fever and ascendent edema ap 

peared a few days after childbirth (October 

1949). Hospitalized, she was treated for 

acute myeloid leukemia with urethane, nicotinic 

acid, and complex B, producing tempo 

rary improvements. The temperature was 

elevated and fluctuating during all the stages 

of the disease. The patient died in December 

1951." - Leukemia Abstr. 

444 

Aznar Reig, A., Llogregat Gonzalez, N., Viejo 

Fonteli, A. and Torres Ruiz, A. EL URETANO 

EN EL TRATAMIENTO DE LAS LEUCEMIAS CRÃ“NICAS. 

[URETHANE THERAPY OF CHRONIC LEUKEMIAS.] 

Medicina, Madr., 1948, 1(5: 310-328. tab. 

14 refs. Four cases. 

445 Batir, E. ZUR DAUERBEHANDLUNG DER CHRONISCHEN 

MYELOISCHEN LEUKÃ„MIE MIT URETHAN. [PROLONGED 

URETHANE THERAPY OF CHRONIC MYELOID LEUKEMIA.) 

Arch. inn. Med., 1951, U 692-698. 17 refs. 

446 Bedinger, P. L. FURTHER STUDIES ON THE EFFECT 

OF URETHANE ON LEUCEMIA. J. Laborat. Clin. 

M., 1948, 33: 1647-1648. Study of 85 cases. 

447 

Bedinger, P. L., Poncher. H. G. and Limarzi, 

L. R. EFFECT OF URETHANE ON LEUCEMIA. 

J. Laborat. Clin. M., 1947, 3_2: 1393-1395. 

It is concluded from this clTnical study 

that: "(1) in patients with acute leucemia 

urethane in oral doses of 1 to 5 Gm. daily 

will produce moderate to marked fall in 

the leucocyte count during a period of one 

to several weeks; (2) in patients with 

chronic lymphatic leucemia and chronic 

myeloid leucemia there is a tendency for 

the blood pattern to approach a more mature 

type with a decrease in the size of the 

lymph nodes and spleen; (3) the temporary 

remission induced by the drug in chronic 

leucemia is never as complete as that fol 

lowing roentgen therapy; (4) there is no 

indication that urethane has any permanent 

effect on the leucemie process." 

448 Belaisch, J. LE LEUCOSE MYELOIDE ET SON TRAITE 

MENT [MYELOID LEUKEMIA AND ITS TREATMENT] . 

Bull, mÃ©Ã .,Par., 1954, 68: 123-124. 

44Berman, L. and Axelrod, A. R. EFFECT OF URETHANE 

ON MALIGNANT DISEASES; CLINICAL, HEMATOLOGIC 

AND HISTOLOGIC OBSERVATIONS ON PATIENTS WITH 

CARCINOMA, LEUKEMIA AND RELATED DISEASES. 

Am. J. Clin. Path., 1948, 18: 104-129. 27 refs. 

Abstracted in: Excerpta medT, Sect. 5, 1949, 

21 No. 2005. 

450 

Berman, L., Axelrod, A. R., Sharp, E. A. and 

Vonder Heide, E. C. EXPERIENCES WITH URETHANE 

IN EIGHT PATIENTS WITH MALIGNANT DISEASE. 

Proc. Centr. Soc. Clin. Res.. 1947, 20: 40- 

41. Also in: J. Laborat. Clin. M., T947, 32: 

1431-1432. 

451 ,, 

Bernard, A. TRAITEMENT D'UNE LEUCEMIE MYELOIDE 

PAR L'URETHANE. [URETHANE TREATMENT OF MYELOID 

LEUKEMIA]. J. se. mÃ©d. Lille, 1947, 65: 496- 

499. 

452 

Bernard, A. LE TRAITEMENT DES LEUCEMIES WVFJ.Olm:s 

PAR L1 URETHANE. [URETHANE TREATMENT IN HYELOID 

LEUKEMIA]. J. BC. mÃ©d. Lille, 1951, 69: 119- 

122. 

453 

Bisotti, P. L. and Tinozzi, C. C. SULLA PRETESA 

AZIONE TERAPEUTICA DELL'ETILURETANO NEI TUMORI 

MALIGNI. [SUPPOSED THERAPEUTIC EFFECT OF ETHYL 

URETHANE ON 

Tor., 1949, 

MALIGNANT TUMORS.] 

40: pt. 2, 36-38. 

Minerva 

16 refs. 

med., 

Findings basecT on results in 7 cases indicated 

negative effect of ethylurethane.



30 

CARBAMATE, 

ETHYL â€”¿ THERAPY 

(Continued) 

454 Bock, H. E. BEHANDLUNG AUCH NICHT-LEUKÃ„MISCHER 

ERKRANKUNGEN, INSBESONDERE DER LYMOHOGRANULO- 

HATOSE, HIT URETHAN NEBST BEMERKUNGEN ÃœBER DEN 

MECHANISMUS DER URETHANWIRKUNG. [URETHANE 

TREATMENT OF NON-LEUKEMIC DISEASES, ESPECIALLY 

LYMPHOGRANULOMATOSIS, WITH COMMENTS ON THE 

MECHANISM OF ACTION OF URETHANE.] Klin. Wschr., 

1948, 26: 390-396. 28 rets. Urethane in daily 

doses Ã–T 1-8 g, usually 4-6 g, given by mouth 

or by rectum had no effect on the following 

conditions: hypernephroma, gastric carcinoma, 

liver tumors, lung tumors and multiple myeloma. 

It gave temporary regression in Hodgkin's 

disease; striking results in patients with 

lymphogranulomatosis. Urethane is to be con 

sidered primarily as a nuclear poison, rather 

than a mitotic one. 

455 

Bock, H. E. and Gross, R. ERGEBNISSE ZWEIJÃ„HRI 

GER URETHANBEHANDLUNGBEI LEUKOSEN. (1946- 

1948). I. CHRONISCHE MYELOSEN. [TWO YEARS' 

EXPERIENCE WITH URETHANE THERAPY OF LEUKOSES. 

(1946-1948). I. CHRONIC MYELOSES]. Deut. 

med. Wschr., 1949, 74: 953-958. 

456 Bock, H. E. and Gross, R. ERGEBNISSE ZWEI- 

JAHRIGER URETHANBEHANDLUNG BEI LEUKOSEN 

(1946-1948). II. CHRONISCHE LYMPHADENOSEN 

(MIT SARKOMOTOSEN IM LYMPHATISCHEN SYSTEM). 

[TWO YEARS' EXPERIENCES WITH URETHANE THERA 

PY OF LEUKOSES (1946-1948). H. CHRONIC 

LYMPHADENOSES (WITH SARCOMATOSIS OF LYMPHA 

TIC SYSTEM).] Deut. med. Wschr., 1949, 74: 

995-1000. Bibliography, p: 999-1000. 

457 

Bock, H. E. and Gross, R. MÃ–GLICHKEITEN UND 

GRENZEN EINER URETHANBEHANDLUNGBEI MORBUS 

HODGKIN (LYMPHOGRANULOMATOSE), AUCH BEI 

KOMBINATION MIT TUBERKULOSE. [POSSIBILITIES 

AND LIMITATIONS OF URETHANE TREATMENT OF 

HODGKIN'S DISEASE ALONE, AND COMPLICATED BY 

TUBERCULOSIS.] 

^47: 303-323. 

Zschr. 

Appro*. 

klin. Med., 

80 refs. 

1950, 

458 Bock, H. E. and Gross, R. 'ÃœBERDIE URETHAN 

BEHANDLUNG BEI BLUTKRANKHEITEN, BESONDERS 

BEI LEUKOSEN. [URETHAN TREATMENT IN BLOOD 

DISORDERS, ESPECIALLY IN LEUKEMIAS.] Aerztl. 

Forsch., 1947, 1J Originalarb., 369-380. 55 

refs. Abstracted in: Chem. Abstr., 1951, 

45: No. 3944e. 

459 

Bock, H. E., Gross, R. and Riethmuller, H. U. 

A'HNLICHKEITEN UND UNTERSCHIEDE IN DER WIR 

KUNG VON URETHAN UND MUSTARD-NITROGEN (N- 

LOSTl. [SIMILARITIES AND DIFFERENCES IN 

ACTION OF URETHANE AND NITROGEN MUSTARD] . 

Verb. Deut. Ges. inn. Med., 1949, 55: 389- 

395. 

460 Bonora, G. LA TERAPIA DELLE LEUCEMIE CON L'URE- 

TANO; CONTRIBUTO CLÃ•NICO. [TREATMENT OF LEU 

KEMIA WITH URETHANE; CLINICAL CONTRIBUTION.] 

Riv. pat. clin., Parma, 1949, 4: 364-379. 

22 refs. five case histories. 

Burgstedt, H. NEUERE BEHANDLUNGSVERFAHREN BEI 

DER LEUKÃ„MIE DES KINDES. [NEW METHODS OF 

TREATING LEUKAEMIA IN CHILDREN.] Munch, med. 

Wschr., 1952, 94: 1468-1475. 26 refs. "The 

effect of various therapeutic measures based 

on different pathogenic theories was tested 

in 50 cases of leukaemia in children...Among 

the cytostatic drugs, the estrogens and some 

resting nuclear poisons such as urethan, 

nirvanol and nitrogen mustard had an unfavour 

able effect on the affection and are therefore 

contra-indicated. Treatment with ACTH and 

anti-folic acid compounds resulted in re 

mission in 20-50% of cases and considerably 

increased the survival time. A true cure, 

however, has so far not been obtained." 

462 

CaBon Raby, A. TRATAMIENTO DE LAS LEUCEMIAS 

CON URETANO. URETHANE TREATMENT OF LEUKE 

MIA] . 70p. Santiago, 1947. (Tesis-Univ. 

de Chile). 14 refs. Nine case histories of 

patients with chronic myeloid leukemia ob 

served from 3-9 months and one with acute 

myeloblastic leukemia are presented. Course 

of treatment is described. 

463 

Cervini, C. CASI DI EMOBLASTOSI TRATTATI CON 

ETILURETANO E CONSIDERAZIONI CLINICHE ED 

EMATOLOGICHE SULLA TERAPIA URETANICA IN GENERE. 

[HEMOBLASTOSIS TREATED WITH ETHYL URETHANE; 

CLINICAL AND HEMATOLOGIC STUDY OF URETHANE 

THERAPY.] Clin, nuova, Roma, 1949, 9: 175-195. 

70 refs. Six cases. 

464 

Chini, V. PAZIENTI TRATTATI CON SOSTANZE CITO- 

STATICHE NELLA CLÃ•NICA MEDICA DI BARI. 

[PATIENTS TREATED WITH CYTOSTATIC SUBSTANCES 

IN THE MEDICAL CLINIC OF BARI.] Minerva med., 

Tor., 1949, 40: pt. 2, 313. 

465 

Cifarelli, E. RELAZIONE SU OTTO CASI DI LEU 

CEMIA ACUTA SOTTOPOSTI A TRATTAMENTO CON URE 

TANO ETILICO PER VIA ORALE. [REPORT ON LIGHT 

CASES OF ACUTE LEUKEMIA TREATED ORALLY WITH 

ETHYLURETHANE.] Minerva med., Tor., 1949 

40: pt. 2, 287-289. 

466 

Ciurdariu, P., loanovici, G., Canea, N. and 

SÃ¢rbu, I. TRATAMENTAL LEUCEMIEI CRONICE CU 

URETHAN. [TREATMENT OF CHRONIC LEUKEMIA 

WITH URETHANE.] Ardeal. med., Cluj, 1949, 

8: 125-6. Urethane in doses of 0.5-1 g 

per day administered to 3 patients with 

chronic leukemia decreased the leucocyte 

count and in general modified the blood pic 

ture . 

467 

Cooper, T. amd Watkins, C. H. ETHYL CARBAMATE 

(URETHANE) IN THE TREATMENT OF CHRONIC MYELOCYTIC 

LEUKEMIA; RESULTS OF A 3 YEAR STUDY. Med Clin 

N. America, 1950, 34: 1205-1215. 24 refs. 

468 

Creskoff, A. J., Fitz-Hugh, T., Jr., and Frost, 

J. W. URETHANE THERAPY IN LEUKEMIA. Blood, 

N. Y., 1948, 3: 896-910. 3 refs. Abstracted 

in: Biol. Abstr., Bait., 1949, 23: No. 7225. 

Briefer treatment of this reporVappears with 

discussion in: Rev. Gastroenter., N. Y 1949, 

16: 243-249. 

469 Debray, J. L'URETHANE DANS LES MALADIES DU 

SANG. [URETHANE IN THERAPY OF BLOOD DISEASES.] 

Sem. hop. Paris, 1950, 26: 1228-1230. 18 refs. 

A short review. 

470 

Derifield, R. S. THE EFFECT OF URETHANE IN 

MULTIPLE MYELOMA; REPORT OF 4 CASES. J. Iowa 

M. Soc., 1950, 40: 220-223. 9 refs. Treat 

ment starting wTÃ®h 3 gm of urethane daily 

and reducing it to 1 gm daily until a maxi 

mum dosage of 388 g of urethane was reached, 

resulted in clinical and histl/logical im 

provements in 4 patients. Toxic effects did 

not necessitate discontinuance of therapy.



31 

CARBAMATE, ETHYL â€”¿ THERAPY (Continued) 

471 

Dustin, P., Jr. MODIFICATIONS DE L'HÃ‰MATOPOÃ•ESE 

DANS LA LEUCEMIE MYÃŒLOIDECHRONIQOT TRAITÃ‰E 

PAR LE CARBAMATE D'ETHYLE. [MODIFICATIONS 0F 

THE HEMATOPOIESIS IN CHRONIC MYELOID LEUKEMIA 

TREATED 

1947, 27: 

WITH 

1763-1774. 

ETHYL-CARBAHATE 

25 reÃs' 

. 1 Bruxelles mid 

" 

472 

Dustin, P., Jr. L'UHETHANE ET SON ASSOCIATION 

X LA RADIOTHERAPIE DANS LES LEUCÃ‰MIES HUMAINES 

[URETHANE AND COMBINED X-RAY TREATMENT IN 

HUMAN LEUKEMIA.] Rev. beige path., 1949, 19: 

115-174. Bibliography p. 169-174. "Hernato^ 

logical and clinical study of 14 chronic myelogenous 

leukemias, 10 chronic lymphatic and 

2 acute monocytic leukemias." 

473 

Dustin, p Jr. and Simon, S. NOTE PRÃ‰LIMINAIRE 

â€¢¿^â€žÂSSOCIATION DE LA CHIMCTHERAPli ET DE 

LA RADIOTHERAPIE DANS LE TRAITEMENT DES LEU 

CEMIES MYÃ‰LOÃ•DESCHRONIQUES. [PRELIMINARY 

REPORT ON COMBINED TREATMENT OF CHRONIC MYELOID 

LEUKEMIA WITH CHEMOTHERAPY AND RADIOTHERAPY 1 

J. beige radiol., 1948, 31: 149-155. 10 refs 

474 

bSÃ¯5a,ra,',JÃŽ,- BEITRAG ZUR URETHANBEHANDLUNG 

DER LEUKÃ„MIEN . [URETHANE THERAPY OF LEU 

KEMIA). Aerztl. Wschr., 1950, 5: 597-599 

16 refs. ~ 

475 

Evans, T. S., Waters, L., Hardin, B., Matosslan, 

N., Coltra, E. and Luca, V. de CARCINOME 

PRIMITIF DU FOIE, APPARU CHEZ UN SUJET ATTEINT 

DE LEUCÃ‰MIE MYÃ‰LOÃ•DETRAITEE PAR L'URÃ‰THANE. 

[PRIMARY CARCINOMA OF THE LIVER IN MYELOGENOUS 

LEUKEMIA TREATED WITH URETHANE.] Rev. hÃ©mat., 

1951, 6: 148-156. 12 refs. 

476 

Fadda, c. F., Lucchini, M. A. and Vera, G. 

MIELOMA. 

1953, 6: 

[MYELOMA.] Rev. med. Valparaiso, 

370-411. al refs. Abstracted in! 


Urethane, cortisone, ACTH and radiotherapy 

produced only transient remissions in 8 

cases of multiple myeloma. 

477 

Fava, P. L. CONSIDERAZIONI SULLA TERAPIA ETIL- 

URETANICA DELLE LEUCEMIE MIELOIDI CRONICHE. 

[ETHYLURETHANE THERAPY IN CHRONIC MYELOID 

LEUKEMIAS.] Sangue, Milano, 1949, 22: 69- 

78. 15 refs. 

478 

FehÃ©r, L. AZ URETHAN THERÃ„PIÃ„ROL. [URETHANE 

THERAPY.] Orv. lap., 1949, 5: 216-219. 

13 refp. A report on urethane treatment in 

16 patients with polycythemia vera, lymphoid 

and myeloid leukemia. Best results were 

achieved when no previous therapy had been 

used. 

479 

Fellinger, K. UEBERDIE URETHANBEHANDLUNG LEU- 

KAMISCHERUND VERWANDTERZUSTÃ„NDE. [URETHANE 

TREATMENTOF LEUKEMIAAND SIMILAR AFFECTIONS.] 

Wien. klin. Wschr., 1948, 60: 359-360. Dis 

cussion: p. 359-360. 

480 

Fellinger, K. URETHANBEHANDLUNG VON LEUKÃ„MIEN. 

[URETHANE TREATMENT OF LEUKEMIA.] Wien. klin. 

Wschr., 1948, 60: 558-565. Approx. 25 refs. 

481 

Fenicia, M. SU ALCUNE MODERNE TERAPIE DEL 

MORBO DI VAQUEZ. [MODERN THERAPY OF VAQUEZ' 

DISEASE.] Rass. internaz. 

29: 457-466. 11 refs. 

clin, ter., 1949, 

482 

Ferrarlo, E. IL COMPORTAMENTO DEL METABOLISMO 

DI BASE E DELLA VELOCITA DI ERITROSEDI 

MENTAZIONE NELLE LEUCEMIE CRONICHE TRATTATE 

CON ETILURETANO. [BASAL METABOLISM AND 

VELOCITY OF ERYTHROCYTE SEDIMENTATION IN 

CHRONIC LEUKEMIAS TREATED WITH ETHYL-URE- 

THANE.] 

225-258. 

Arch, sc. 

98 refs. 

med., Tor., 1949, 87: 

Observations in 10~ 

cases. A digest of this article appears in- 

Minerva ned., Tor., 1949, 40: pt. 2, 299. 

483 

Fitzenkam, A., and Voegtlin, R. . TRAITEMENT DES 

LEUCÃ‰MIESPAR L'URÃ‰THANE. . [URETHANE TREATMENT 

OF LEUKEMIA]. Strasbourg med . , 1948, 108- 197- 

200. 

484 

Fonseca, F., Fraga de Azevedo, J. and Marques 

da Gama. M. TRATAMENTO DAS LEUCEMIAS PELO URE- 

TANo.[TREATMENT OFLEUKEMIAS WITHURETHANE.] 

Clin, contemp., Lisb., 1949, 3: 1165-1185. 

11 refs. English summary. Findings based on 

22 cases treated with urethane are reported. 

485 

Fritze, E., Schoen, R. and Schulze, E. 3 l/Z 

JÃ„HRIGEERFAHRUNGENÃœBERDIE BEHANDLUNGVON 

LEUKÃ„MIENMIT URETHAN. [ 3 1X2-YEAR EXPERIENCE 

IN THE TREATMENTOF LEUKEMIAWITH URETHANE]. 

Deut. 

23 refs. 

Arch. 

Abstracted 

klin. Med., 

in: 

1950, 

Chem.~SBstr 

197: 69-83. 

. , 1951, 

45: 8140a. 

486 

Fukushima, S., Senda, N., Naka, K., Uchibori, K. 

and Okuda, M. EFFICACY OF URETHANE THERAPY 

IN LEUKEMIA. Rinsyo naika syonika, 1949, 4: 

570-572. 4 refs. In Japanese. 

487 

CadrÃ¢t, J. and SÃ©riÃ©,C. L'URÃ‹THANE DANS LE 

TRAITEMENT DES LEUCEMIES CHRONIQUES. [URE 

THANE TREATMENT OF CHRONIC LEUKEMIA.] 

Toulouse 

A review 

mÃ©d., 

dealing 

1949, 

with 

585-591. 

dosage, mode 

6 refs. 

of' 

administration and effects of treatment. 

488 

Gajardo, T. R. and Silva, L. C. ACCIÃ“N TERA 

PEUTICA DEL URETANO EN LEUCEMIAS. [THERA 

PEUTIC EFFECT OF URETHANE IN LEUKEMIAS] . 

Rev. med. Valparaiso, 1948, 1: 22-28. 6 refs. 

489 

Garbato, B. SULL'AZIONE DELL 'ETILURETANO NELLA 

CURA DELLE LEUCEMIE. [EFFECTS OF ETHYL URE 

THANE IN TREATMENT OF LEUKEMIA.] Arch. 

Maragliano 

fold. tab. 

pat. clin., 1949, 4: 1141-1148. 

23 refs. English~summary. Treat 

ment of six cases of leukemia with urethane 

are described. There were failures in leukemic 

lymphoadenosis, partial remissions ob 

tained in chronic leukemic myelosis and good 

results in monocytic leukemia. 

490 

491 

laies Â»ftS 

^recommended 

DIE 

Â°n7 

,LECHENIE KHRONICHESKIKH LEÃ•KOZOV 

[â„¢EATMENT OFCHRONICLEUKEMIAWITH 

Klin. med. Moskva, 1951, 29: 77- 

79. 6 refs. Abstracted in: ExcerptalTed. , 

Sect. ec. 2, , 1952, 5: No. 1685. Results obtained 

in 38 cases of chronic myelogenous leukemia.



32 

CARBAMATE, 


(Continued) 

492 

Glanzmann, E. URETHANBEHANDLUNG VON SYMPATHO- 

GONIOM-METASTASEN IN DER HAUT UND DIE FRAGE 

DER MONOBLASTENLEUKJOÃ•IE. [URETHANE THERAPY 

OF SYMPATHOGONIC METASTASES IN SKIN AND THE 

PROBLEM OF MONOBLASTIC LEUKEMIA.] Ann. 

paediat., Basel, 1949, 172: 210-217. Dis 

cussion p. 217-218. A newborn was treated 

with l g of urethane per day. After four 

weeks of treatment the skin mÃ©tastases re 

gressed and almost disappeared completely. 

Leucopenie and anemia, as well as a fall in 

the number of lymphocytes developed. After 

treatment for 4 1/2 months the infant died 

with symptoms of interstitial plasma cell 

pneumonia. 

493.. 

Goksei, F. M. LÃ–SEMITEDAVISINDE URETAN. [URE 

THANE IN THE THERAPYOF LEUKEMIA.] Tip fak 

mecmuasi., Istanbul, 1949, 12: 559-589. 

47 refs. English summary. ~ 

494 

Goldeck, H. URETHANWIRKUNG BEI PARAMYELOBLASTOSEN 

(AKUTEN MYELOBLASTENLEUKÃ„MIEN) UND RETOTHELIOSE 

[THE EFFECT OF URETHANE IN PARAMYELOBLASTOSES 

(ACUTE MYELOBLASTIC LEUKEMIAS) AND RETICULOSIS 1 

Aerztl. Wschr., 1948, 3: 490-493. 20 refs 

In three patients with acute myeloblastic leu 

kemia, urethane therapy had only temporary ef 

fects on the decrease of the leucocyte count. 

The drug caused panmyelophthisis. 

495 

Goodman, M. J. and Lewis, H. P. URETHANE IN 

LEUKEMIA. J. Am. M. Ass., 1946, 132: 1105. 

496 

Groth, W. ERFAHRUNGEN MIT DER URETHANTHERAPIE 

DER LEUKOSEN. [EXPERIENCES WITH URETHANE 

THERAPY OF LEUKOSES.] Zschr. ges. inn. Med., 

1953, 8: 312-321. 37 refs. Thirteen cases 

of myeTosis and 11 of lymphoadenosis were 

treated by the author; detailed clinical re 

ports of 5 cases are given. 

497 

Gullberg, B. THE EFFECT OF URETHANE IN LEU 

KEMIA AND MULTIPLE MYELOMA. Acta med 

scand. 

69-74. 

suppl. No. 

7 refs. 

259, (1950) 1951, 140: 

498 

Haddow, A. THE CHEMOTHERAPY OF CANCER. Brit 

M. J., 1950, 2: 1271-1272. Report of a 

lecture. 

499 

Haines, R. D. and Powell, W. N. MULTIPLE MYE 

LOMA; REPORT OF 51 CASES; SOME OBSERVATIONS 

WITH URETHANE THERAPY. J. Louisiana M. Soc 


Chem. S15str., 1954, 48: 4091g. 

500 

Haines, R. D., Powell, W. N. and Bailey, H. A. 

MULTIPLE MYELOMA: ITSTREATMENT WITHURETHANE 

AND ACTH. South. M. J., 1951, 44: 467-478. 

25 refs. Treatment in two cases~with 1 1/2- 

2 g of urethane daily, tablet or liquid, 

resulted in beneficial effects. Though one 

of the patients died, the other patient, 

followed for seven months, experienced relief 

of bone pain and showed healing of fracture. 

In another case, where both urethane and 

ACTH were administered the patient showed 

marked subjective improvement, with relief 

of bone pain and alteration of blood picture 

tâ€žwaranormal. The authors attribute the 

beneficial effects to urethane and feel that 

ACTH produced no added improvement. 

501 

Hajman and Gorecki, R. PRZYCZYNEK DO LECZENIA 

BIALACZEK URETANEM. [URETHANE TREATMENT OF 

LEUKEMIA.] Nowiny lek., 1948, 55: 313-318-. 

34 refs. A review of the literature on the 

effect of urethane on tissue and on the 

hemopoietic substance of man is followed by 

Â»description of treatment with the drug. 

Urethane gave good results in 4 cases of myeloid 

and 1 case of lymphatic leukemia and 

unfavorable results in 1 case of myeloid 

leukemia. Only nausea was noted as a side 

effect. 

502 

Hall, B. EXPERIENCE WITH ETHYL CARBAMATE IN 

THE TREATMENT OF LEUKEMIA. Bull. Chicago 

M. Si"-..,1949, 5_1: 803. RÃ©sumÃ©of results 

obtained with urethane in treatment of 52 

cases of myelogenous leukemia. 

503 

Hansen, P. B. URETHANBEHANDLING VED LEUCOSE; 

ET AARS ERFARINGER. 

LEUKEMIA; ONE YEAR'S 

[URETHANE TREATMENT OF 

STUDY.] Nord, med., 

1948, 38: 930-934. English summary. 

Treatment of 27 patients. 

504 

Hansen, P. B. URETHANE THERAPY IN LEUKEMIA, 

WITH A FEW REMARKS ON THE RELATION BETWEEN 

URIC ACID EXCRETION, BASAL METABOLIC RATE, 

AND BLOOD COUNTS. Proc. Congr. Internat. 

Soc. Hemat., (1950) 1951, 3. meet., 349- 

356. 15 refs. 

505 

Harrington, W. J. and Moloney, W. C. THE TREAT 

MENT OF MULTIPLE MYELOMA 

N. Y., 1950, 3: 253-271. 

WITH URETHANE. Cancer, 

15 refs. Eleven 

patients with multiple myeloma were treated 

over periods of 4 weeks to 27 months with 

urethane given orally, usually in doses of 3-6 

g daily, though occasionally 12 g daily was 

administered. Three of 5 patients who died 

failed to respond to the drug. These were 

believed to represent acute forms of multiple 

myeloma. Striking clinical improvements, 

probable prolongation of life, improvement in 

anemia, reduction in abnormal serum proteins 

and suppression of myeloma cell proliferation 

in the bone marrow were observed in 6 patients. 

506 Heilmeyer, L. VOLLSTÃ„NDIGER R'UCHGANGEINES 

GROSZEN ABDOMINALTUMORS (RETOTHELSARKOM?) 

NACH URETHANBEHANDLUNG. [COMPLETE REMISSION 

OF A LARGE ABDOMINAL TUMOR (RETICULOSAHCOMA?) 

FOLLOWING TREATMENT WITH URETHANE.] Med. 

Klin., Beri., 1947, 47: 627-628. 

507 

Hirano, H. TREATMENT OF LEUKEMIA BY INJECTIONS 

OF URETHANE INTO THE BONE-MARROW. Rinsyo 

naika syonika, 1949, 4: 731-732. In Japanese. 

508 

Hirschboeck, J. S., Lindert, M. C. F., Chase, J. 

and Calvy, T. L. EFFECTS OF URETHANE IN THE 

TREATMENT OF LEUKEMIA AND METASTATIC MALIGNANT 

TUMORS. J. Am. M. Ass., 1948, 136: 90-95. 

Abstract of discussion: p. 94-95TApprox. 

23 refs. Observations in 25 cases. 

509 

Hittmair, A. DIE URETHANBEHANDLUNGDER LEUKÃ„MIEN. 

[URETHANE TREATMENT IN LEUKEMIA]. Wien. klin. 

Wschr., 1949, 61: 36. 

510 

Horak. J. NEKTERÃ‰ NOVÃ‰ LÃ‰CEBNÃ‰METHODY V IN 

TERNI KLINICKE PRAXI. [NEW THERAPEUTIC ME 

THODS IN INTERNAL CLINICAL PRACTICE.] Lek. 

listy, 1947, 2: 580-588. 28 refs. Results 

of urethane treatment in 4 cases of lympha 

tic and 4 cases of myeloid leukemia, and in 

3 cases of thrombocytopenia are discussed. 

Intravenous injection of 1% novocaine solu 

tion reversed the toxic effect of urethane 

in one patient.



33 

CARBAMATE, 


(Continued) 

511 v 

Hrubisko. II., K TERAPJI 

KAZUISTICKYM SDELENIH 

LEUKOZ URETANOM S 

DVOCH PRIPADOV PAN- 

MYELOPATIE PO URETANE. [TREATMENT OF LEU 

KEMIA WITH URETHANE WITH TWO CASE HISTORIES 

OF PANMYELOPHTHISIS CAUSED BY URETHANE.] 

Bratisl. lek. listy, 1948, 28: 401-407. 

tab. 12 refs. Complete remissions 

achieved in 6 patients with chronic 

were 

myeloid 

leukemia treated with 86 g urethane 

over a period of 22 days. In 2 cases of 

chronic myeloid leukemia a complication 

of panmyelophthisis was caused by the ure 

thane treatment. Urethane therapy was un 

satisfactory in acute and lymphatic leu 

kemia cases. 

512 

HrubiÃ¯ko, M. PRÃ•SPEVOK K UCINKU URETANU U 

LEUKOZ. 

Bratisl. 

[ACTION OF URETHANE IN LEUKEMIA.] 

lek. listy, 1948, 28: 554-561. 

8 refs. Urethane in doses up to 80 g ad 

ministered to three patients with chronic 

myeloid leukemia inhibited leucocyte mito 

sis, increased the "ripe" and decreased the 

"unripe" leucocyte count of the bone mar 

ro*. Urethane showed no changes on the 

blood picture of patients with acute leu 

kemia. 

513 

Huggins, C., Yu, S. T. and Jones, R., Jr. IN 

HIBITORY EFFECTS OF ETHYL CARBAMATE 

STATIC CANCER. Science, 1947, 106: 

ON PRO- 

147-148. 

12 refs. 

514 -v 

Hule, V. LECBA POLYCYTHAEMIA VERA URETANEM. 

[THERAPY OF 

Lek. listy, 

POLYCYTHEMIA VERA WITH URETHANE.] 

Brno, 1949, 4: 283-286. Polycythemia 

vera in two males, age 52 and 55 and 

one female, age 51 was treated with urethane 

in doses from 32.5 rag. to 84 mg. Two re 

missions occurred within three months; the 

longest remission lasted for seven months. 

The number of erythrocytes in these periods 

was lowered from 8.7-9.9 million to 6.8- 

5.4 million. 

515 

Hule, V.â€žURETAN, JEHO ÃšÃ•INEKBIOLOGICKY A 

LECEBNY. [URETHANE AND ITS BIOLOGIC AND 

THERAPEUTIC EFFECT]. 

1949, 4: 412-414. A 

Lek. listy, Brno, 

historical review of 

urethane from the time it was first syn 

thesized in 1834 through 1949, with a 

report of its use in cases of polycythemia 

vera. 

516 

Jadassohn, W. MYCOSIS FONGOÃ•DE TRAITÃ‰ Ã€L'URÃ‰- 

THANE. [URETHANE TREATMENT IN MYCOSIS FUN- 

GOIDES.] Dermatologica, Basel, 1948, 96: 

274. 

517 Jamr.a, M. A. and Mendes, F. T. ANÃ„LISE HEMATO- 

LOGICA E CLÃ•NICA DO TRATAMENTO DE DEZ CASOS 

DE LEUCEMIA PELA URETANA. [HEMATOLOGIC AND 

CLINICAL FINDINGS IN THE URETHANE TREATMENT 

OF TEN CASES OF LEUKEMIA.] Rev. Hosp. clin., 

S. Paulo, 1948, 3: 23-42. 10 refs. 

518 Janele. J. PRISPEVEK K POKUSUM 0 LECENI CHRO- 

NICKYCH MYELOS. [ON THE TREATMENT OF CHRONIC 

MYELOSIS.] Pediat. listy, Praha, 1947, 2: 

261-266. 8 refs. Treatment with urethane, 

antireticular cytotoxic serum and x-rays of 

chronic myelosis in a five year old boy is 

discussed. Besides the palliative results 

of the urethane and ACS, the general outcome 

of the treatment was unsatisfactory. 

519 

Karnofsky, D. A. THE MANAGEMENT OF LEUKEMIA 

IN ADULTS. N. York State J. M., 1954, 54: 

3225-3228. 9 refs. A review. 

520 

Katz. S. CYTOSTATISCHE STOFFE IN DER BEHANDLUNG 

DEA LEUKÃ„MIE. [CYTOSTATIC SUBSTANCES IN THE 

TREATMENT OF LEUKEMIA.] 28 1. MÃ¼nchen, 1954. 

(Inaug. T>Â¡ss.,MÃ¼nchen). 42 refs. A re 

view of the action of urethane, nitrogen mus 

tard and aminopterin. 

521 

Kelemen, E., BenkB, A. and TÃ©nyi, M. P-AMINO- 

BENZOESXURE-URETHAN-INTERFERENZ BEI MENSCH 

LICHEN LEUKÃ„MIEN. [P-AMINOBENZOIC ACID- 

URETHANE INTERFERENCE IN HUMAN LEUKEMIAS] . 

Experientia, Basel, 1949, 5: 77-78. 2 refs. 

522 

Kennedy, B. J., Nathanson, I. T. and Aub, J. C. 

ETHYL CARBAMATE (URETHANE) IN THE TREATMENT 

OF MYCOSIS 

3_: 66-73. 

FUNGOIDES. Cancer 


N. Y., 1950, 

523 Kjerulf-Jensen, K. URETANBEHANDLINGEN AF LEU- 

CAEMI. [TREATMENT OF LEUKEMIA WITH URETHANE.] 

Ugeskr. laeger, 1947, 109: 85-87. 5 refs. 

524 

Koch, F. ÃœEBERAETHYL-URETHANBEHANDLUNG DER 

MYCOSIS FUNGOIDES. [URETHANE TREATMENT OF 

MYCOSIS FUNGOIDES.] Derm. Wschr., 1947- 

1948, 119: 713-715. 

525 

KolÃ¡r, V. O LÃ‰OENÃ•LEUKAEMIÃ•. [TREATMENT OF 

LEUKEMIA]. Lek. listy, 19eO, 5: 48-51. 

Urethane and nitrogen mustard were administer 

ed in conjunction with x-ray therapy to 

57 patients with chronic leukemia. The 

results of irradiation are considered su 

perior to those of urethane and nitrogen 

mustard. 

526 

Krause, P. URETHANBEHANDLUNG EINER CHRONISCHEN 

LYMPHADENOSE DER HAUT. [URETHANE THERAPY OF 

CHRONIC 

Wschr., 

LYMPHADENOSIS OF THE 

1950, 121; 105-107. 

SKIN.] 

A total 

Derm 

dose'of 

130 g urethane caused essential normalization 

of blood picture and regression of skin lesions. 

527 

KÃœnzer, W. URETHANWIRKUNGBEI DER "INFEKTIÃ–SEN 

RETICULOENDOTHEHOSE" (ABT-LETTERER-SIWESCHE 

KRANKHEIT) . [THE EFFECT OF URETHANE ON THE 

"INFECTIOUS RETICULOENDOTHELIOSIS" (ABT- 

LETTERER-SIWE DISEASE).] Klin. Wschr., 1948, 

26: 694-695. 4 refs. 

528 

Lambet. TRAITEMENT DES LEUCÃ‰MIES PAR L'URETHANE. 

[URETHANE TREATMENT OF LEUKEMIA.] Praxis, Bern, 

chroni5~~and 1948, 37: 457. 13 ofSummary acute report leukemia. of 17 cases of 

529 

Lambin. P. and Masure, R. LE TRAITEMENT DES 

LEUCEMIES PAR L'URETHANE. [URETHANE TREAT 

MENT OF LEUKEMIA.] Schweiz, ned. Wschr., 

1948, 78: 929-931. 15 refs. Results in 

31 cases" of leukemia. 

530 

Landoli, R. F. ZUR BEHANDLUNG DER AKUTEN LEU 

KÃ„MIEN IM KINDERSALTER MIT URETHAN. [URETHANE 

TREATMENT OF ACUTE LEUKEMIAS IN CHILDREN.] 

Helvet. paediat. acta., 1948, 3: 232-251. 

15 refs. 

531 

Languillon, J. LE TRAITEMENT DE LA LEUCÃ‰MIE 

MYELOIDE PAR L'URETHANE; (X PROPOS D'UN CAS 

PERSONNEL). [TREATMENT OF MYELOID LEUKEMIA 

WITH URETHANE; ONE PERSONAL CASE.] Med. 

trop., 1950, 10: 846-850.



34 

CARBAMATE, 


(Continued) 

532 

Lapides, J. CLINICAL VALUE OF URETHANE THERAPY 

IN PROSTATIC CANCER. Cancer, N. Y., 1949, 2: 

469-474. 18 refs. Abstracted in: Biol. Abstr., 

Bait., 1949, 28: No. 20929. Urethane Â«as of 

no clinical vÃ¤Tue. 

533 

Lattanzi, A. CASI DI LEUCEMIA TRATTATI CON 

URETANÃ“ ETILICO. [LEUKEMIA TREATED WITH 

ETHYLURETHANE.] Minerva med., Tor., 1949, 

40: pt. 2, 289-292. 

534 

Lawley, M. and Mekie, D. E. NASOPHARYNGEAL 

CARCINOMA. II. TREATMENT WITH URETHANE 

(ETHYL CARBAMATE) 

Surg. Oyn. Obst., 

AND TRIETHYLENE MELAMINE. 

1955, 101: 141-152. 

10 reÃs. 

535 

Ledile, E. M. CHRONIC MYELOID LEUKAEMIA. II. 

A COMPARATIVE ANALYSIS OF THE INCIDENCE AND 

OF THE RESULTS OF TREATMENT OF 56 CASES. 

Brit. J. Radiol., 1953, 26: 290-295. tab. 

23 refs. 

536 Letterer, E. PATHOLOGISCH-ANATOMISCHE BEOBACH 

TUNGEN AN URETHANBEHANDELTEN ERKRANKUNGEN. 

[PATHO-ANATOMICAL OBSERVATIONS ON DISEASES 

TREATED WITH URETHANE.] Klin. Wschr., 1948, 

26: 385-390. 3 refs. 

537 

Leucutia, T. URETHANE THERAPY. Am. J. Roentg., 

1948, 59: 421-424. 10 refs. A review. 

544 

Luttgens, Â».F. and Bayrd. E. D. TREATMENT OF 

MULTIPLE MYELOMA WITH URETHANE. EXPERIENCE 

WITH SIXTY-SIX CASES OVER A TWO-AND-A-HALF- 

YEAR PERIOD. J. Am. M. Ass., 1951, 147: 824- 

827. 10 refs. 

too encouraging 

While the results were not 

it was concluded that urethane 

is probably as good a treatment as is 

available for multiple myeloma at the present 

time. 

545 

Lutze, F. H. LEUKEMIA AND PREGNANCY, WITH CASE 

REPORT. Am. J. Roentg., 1953, 69: 608-612. 

17 refs. A case of chronic myeTBid leukemia 

with co-existing pregnancy was controlled by 

transfusions and small doses of roentgen 

therapy through the prenatal period. Follow 

ing the birth of a normal female child, the 

patient's condition was controlled by roentgen 

therapy for six months and thereafter by urethane. 

The patient was symptomatically well 

1 1/2 years after childbirth. 

546 

Â«Maffre de Bauge, E. DE L'UTILISATION DE L'URE 

THANE 

1949. 

DANS LE TRAITEMENT 

(ThÃ¨se-Paris). 

DES LEUCEMIES. 36p. 

547 

Maki, T. and Kawamura, K. URETHANE TREATMENT 

FOR MEDULLARY LEUKEMIA IN CHILDREN. Sindan 

& tiryo, 1950, 38: 41-44. In Japanese. 

548 

Marlow, A. A. and Bartlett, G. R. NEWER THERA 

PY FOR LEUKEMIA, POLYCYTHEMIA, AND LYMPHOMA. 

California M , 1953, 78: 91-94. 10 refs 

538 549 

LibÃ¡nsky, J. and Trojan, J. LECENI LEUKEMII 

Masshoff, W. and Heinzel, W. DAS PATHOLOGISCH 

ANATOMISCHE BILD DER URETHANBEHANDELTEN 

URETHAÃŒJEM. [URETHAN THERAPY IN LEUKEMIA.] 

CHRONISCHEN MYELOSE. [PATHO-ANATOMICAL PIC 

Cas. lek. cesk., 1949, 88: 1037-1048. 25 

refs. Urethane, in doses of 0.5-1.0 mg, 

TURE OF CHRONIC MYELOSIS TREATED BY URETHANE.] 

Deut. med. Wschr., 1950, 75: 1722-1726. 20 

administered orally, intravenously and by 

refs. Abstracted in: Excerpta med., Sect. 5, 

suppository, to three patients with chronic 

myeloid leukemia over a period up to 18 

1951, 4: No. 2188. 

months, did not prolong the life, nor im 

550 

prove the overall condition of patients. 

ML-lick, R. A. CHEMOTHERAPY IN THE RETICULOSES. 

Med. J. Australia, 1952, 1: 38-43. 7 refs. 

Lickint,F. OBERDIEBISHERNIEDRIGSTE TÃ–DLICHE 

URETHANMENGE BEI BEHANDLUNG CHRONISCHER LEU 

KÃ„MIEN. [LOWEST LETHAL DOSE OF URETHANE HITHERTO 

USED IN TREATMENT OF CHRONIC LEUKEMIA.] Deut. 

med. Wschr., 1950, 75: 365. 

551 

Merk, R. ÃœBERERFAHRUNGEN DER FREIBURGER KLINIK 

MIT URETHAN, STICKSTOFFLOST UND STILBAMIDIN. 

[EXPERIENCES WITH URETHANE, NITROGEN MUSTARD 

AND STILBAMIDINE AT FREIBURG CLINIC). 

haemat., Lpz., 1951, 70: 52-58. 

Fol. 

540 

Linke, A. KLINISCHE UND EXPERIMENTELLE ERGEB 

NISSE DER DAUERTHERAPIE MALIGNER TUMOREN MIT 

Ã„THYLURETHAN. [CLINICAL AND EXPERIMENTAL 

RESULTS OF PROLONGED ETHYL URETHANE THERAPY 

OF MALIGNANT TUMORS.] Verb. Deut. Ges. inn. 

Med., 1949, 55: 400- 3-406. 

541 

Linke, A. and Mechelke, K. ZUR THERAPIE DER 

LEUKAEMIE UND MALIGNER LYMPHKNOTENTUMOREN 

MIT AETHYLURETHAN. [TREATMENT OF LEUKEMIA 

AND MALIGNANT LYMPHNÃ’DETUMORS WITH URE 

THANE.] Med. Klin., Beri., 1948, 43: 570- 

575. 36 reÃs. 

542 

Loge, J. P. and Rundles, R. W. URETHANE (ETHYL 

CARBAMATE) THERAPY IN MULTIPLE MYELOMA. Blood, 

Bait., 1949, 4: 201-216. 32 refs. Abstracted 

in: Biol. AbsÃ¯r., Bait., 1950, 24: No. 4104. 

Four patients were treated, striking benefits 

were observed. 

543 

Lutterotti, A. de LEUCEMIE TRATTATE CON ETIL- 

URETANO. [LEUKEMIAS TREATED WITH ETHYLURE 

THANE.] Minerva med., Tor., 1949, 40: pt. 2, 

295-297. 

552 

Meythaler, F. and Handel^ F. URETHAN IN DER 

BEHANDLUNG NEOPLASTISCHER UND HAEMATOLO- 

GISCHER ERKRANKUNGEN. [URETHANE IN THERAPY 

OF NEOPLASTIC AND HEMATOLOGIC DISEASES.] 

Aerztl. Forsch., 1949, 3: Originalarb., 497- 

506. 62 refs. 

553 

Michel, H. KRITISCHE BEMERKUNGENUND BEOBACH 

TUNGEN ZUR URETHANTHERAPIE DER CHRONISCHEN 

MYELOSE IN DEN LETZTEN 5 JAHREN. [CRITICAL 

OBSERVATIONS ON URETHANE THERAPY OF CHRONIC 

MYELOSIS DURING THE LAST 5 YEARS]. MUnch. 

med. Wschr., 1952, 94: 117-123. 121 refs. 

554 

Moeschlin, S. DIE THERAPIE DER LEUKÃ„MIEN MIT 

RONTGEN, ARSEN UND URETHAN. [THE THERAPY 

OF LEUKEMIA WITH X-RAYS, ARSENIC AND URETHANE.] 

Helvet. med. acta, 1948, 15: 107-128. 22 refs. 

The literature on the use of arsenic and urethane 

in the treatment of leukemias is reviewed. 

In an addendum one case history of urethane 

treatment with fatal granulocytopenia and one 

case history of chronic myeloid leukemia treated 

with tartar emetic injections are reported.



35 

CARBAMATE, 


(Continued) 

555 

Holler, B. MYEI.OM,ASTIO LEUKEMIA. Acta paediat., 

Upps., 1949, 37: 492-502. 20 reÃs. Abstracted 

in: Excerpta Be~d., Sect. 7, 1950, 4: No. 3005. 

556 

Mortensen, V. BEHANDLING AT LEUKOSER MED URE- 

THAN. [TREATMENT OF LEUKEMIA WITH 

Ugeskr. laeger, 1947, 109: 91-92. 

URETHANE.1 

rÃ©f. 

557 

"uggia, A. CASI SOTTOPOSTI A TRATTAMENTO CON 

URETANO ETILICO. [PATIENTS TREATED WITH 

ETHYLURETHANE.1 Minerva med., Tor., 1949 

40: pt. 2, 323. 

558 

Munk, F. and Boyens. H. ÃœBER DIE URETHANBE- 

HANDLUNG DER LEUKÃ„MIE. [URETHANE TREATMENT 

OF LEUKEMIA.] Ther. Gegenwart, 1947, 137- 

559 

Musso. E. A PROPOS DE 4 CAS DE MYCOSIS FONGOID 

TRAITES PAR L'URETHANE. [URETHANE TREATMENT 

IN 4 CASES OF MYCOSIS FUNGOID). p. 149-160. 

GenÃ¨ve, 1949. (ThÃ¨se-GenÃ¨ve.) 16 reÃs. 

Also in: Oncologia, 1949, 2: 149-160. Tumors 

continued to develop though" slight beneficial 

effects were noted. 

560 

PadrÃ³n Ruiz, E. REPORTE DE UN CASO DE LEUCEMIA 

MIELOIDE CRONICA EN UN LACTANTE TRATADO CON 

URETANO. [REPORT OF A CASE OF CHRONIC MYELOID 

LEUKAEMIA IN AN INFANT TREATED WITH URETHANE.] 

Rev. cubana pediat., 1950, 22: 751-764. 22 

refs. 

1951, 


5: No. 2649. "The onset 

med., Sect. 7, 

of the disease 

was at 2 months. Death followed at the age 

of 11 months, about 2 months after 

with urethan had been instituted." 

treatment 

- Excerpta 

med. 

561 

Paterson, E., Ap Thomas, I., Haddow, A. and 

Ã¯5ÃŽÃ•ÃŽnSOn' J- "' A FURTHER REPORT ON THE 

ACTION OF URETHANE IN LEUKEMIA. In: 

APPROACHES TO TUMOR CHEMOTHERAPY.â€”Wash., 

Am. Ass. Advance. Sc., 1947, 401-415. 

3 refs. 

562 

Paterson, E., Haddow, A., Ap Thomas, I. and 

Watkinson, J. M. LEUKEMIA TREATED WITH 

URETHANE COMPARED WITH DEEP X-RAY THERAPY 

Lancet, Lond., 1946, 1: 677-683. refs. 


Ie~ukemia 21: No. 11674. and 13 Nineteen of lymphatic casesleukemia of myeloid were 

observed over periods ranging between 11 

months and 5 weeks. The drug was also 

given in 13 cases of breast carcinoma and 

11 cases of other types of malignant 

disease. 

563 

Pedro Pons, A., Farreras Valenti, P. and Llebaria, 

C. A. TRATAMIENTO MODERNO DE LAS LEUCEMIAS CON 

URETANO; RESULTADOS DE ESTA TERAPÃÛTICA ANTI- 

MITOTICA EN CINCO CASOS DE LEUCEMIA LINFOIDE 

CRONICA% [MODERN TREATMENT OF LEUKEMIAS WITH 

URETHANE; FINDINGS IN 5 CASES OF CHRONIC LYM- 

PHOID LEUKEMIA TREATED WITH THIS ANTIMITOTIC 

DRUG.] 

3-21. 

Progr. ter. clin., 

pi. 24 refs. 

B. Air., 1948, 1: 

564 

Peeters, H. UHETHAAN EN LEUKAEMIE. [THE TREAT 

MENT OF LEUKAEMIA WITH URETHANE.] Belg. tschr 

geneesk., 1947, 3: 543-546. Abstracted in: 

Excerpta med., 

"Survey of the 

Sect. 2, 1948, 1: No. 3243. 

theory and practice of treat 

ment of leukaemias with urethane." -Excerpta 

565 

566 

Pierce, M. RECENT ADVANCES IN THE TREATMENT 

OF LEUKEMIA IN CHILDREN. Med. Clin. H. 

America, 1950, 201-216. 46 refs. 

567 

Piney, A. URETHANE IN CHRONIC MYELOID LEUKAEMIA. 

Lancet, Lond., 1947, 2: 774. 

568 

Quintanilla Ulla, J. and PunÃn Garrido, C. 

LEUCEMIA MIELOIDE CRÃ“NICA TRATADO CON URE 

TANO. [CHRONIC MYELOID LEUKEMIA TREATED WITH 

URETHANE.] Galicia clÃn., CoruÃ±a, 1949, 

21^: 475-481. 19 refs. 

569 Rosso, G. SU DI UN CASO DI MIELOSI LEUCEMICA 

CRONICA IN UN BAMBINO. [CHRONIC MYELOGENOUS 

LEUKEMIA IN CHILDREN. REPORT OF A CASE.] 

Minerva med., Tor., 1954, 45: pt. 1, 626- 

630. 23 refs. 

570 

Rottini, G. CONSIDERAZIONI SU DI UN CASO DI 

LEUCEMIA ACUTA TRATTATA CON TEROPTERINA ED 

URETANO. [A CASE OF ACUTE LEUKEMIA TREATED 

WITH TEROPTERIN AND URETHANE.] Minerva 

pediat., Tor., 1952, 4: 322-325. 17 refs. 

571 

Rouques, L. L 'URETHANE DANS LES MYÃ‰LOMES. 

[URETHANE IN MYELOMA.] Presse med., 1952, 

6: 158. 

57fr 

Rundles, R. W. and Reeves, R. J. MULTIPLE MYE 

LOMA. II. VARIABILITY OF ROENTGEN APPEARENCE 

AND EFFECT OF URETHANE THERAPY ON SKELETAL 

DISEASE. Am. J. Roentg., 1950, 64: 799-809. 

18 refs. Report of 24 cases of multiple mye 

loma treated with urethane. 16 patients com 

pleted one or more courses of the treatment 

over a period of 2 years with the following 

results: good to excellent, 11 cases; paliative, 

3 cases; no benefit, 2 cases. 

573 

Rundles, R. W., Barton, W. B. and Coonrad, E. V. 

THE ROLE OF CHEMOTHERAPY IN THE MANAGEMENT OF 

MALIGNANT 

1953, 46: 

LYMPHOMAS 

259-268. 

AND LEUKEMIAS. South M. 

44 refs. Abstracted in: 

J. 

Leukemia Abstr., 1953, 1: No. 159. 

574 

Saltzman, F. and Borgstrom, H. MULTIPLE PLASMO- 

CYTOMA TREATED WITH 

1950, 136: 388-392. 

URETHANE. 

2 refs. 

Acta med. SCand., 

Urethane, in 3 

daily SOSes of 1.5 g, was given during repeated 

treatments over a period of 21 months, when the 

patient died. It could not be determined whether 

distinct improvement of patient's condition was 

due to the drug or represented a case of spon 

taneous regression. 

575 

Scarizza, P. M. UN CASO DI LEUCEMIA MIELOIDE 

CRONICA IN UN BAMBINO. TRATTATO CON URETANO. 

[CHRONIC MYELOGENOUS LEUKEMIA IN A CHILD 

TREATED WITH URETHANE.] 

Tor., 1950, 2: 278-284. 

Minerva 

English 

Pediat., 

summary. 

576 

Schoen, R. URETHAN IM LICHTE DER HAMATOLOGIE. 

[URETHANE AND HEMATOLOGY.] Klin. Wschr., 

1947, 24/25! 488-490. 15 refs. 

577 

Schuermann, H. and Binder, E. 

LUNG-DER MYCOSIS FUNGOIDES. 

URETHANBEHAND- 

[URETHANE TREAT- 

578 

Schulte, G. and Lings, H. RÃ–NTGEN- UND URE- 

THANBEHANDLUNGDER LEUKAEMIEN UND ARTVER 

WANDTER TUMOREN. [URETHANE AND X-RAY THERAPY 

OF LEUKEMIA AND ALLIED NEOPLASMS.] Strahlen 

therapie, 1948, 78: 245-256. 10 refs.



36 

CARBAMATE, ETHYL â€”¿ THERAPY 

(Continued) 

579 

Schulten, H. and Levens, H. E. ZUR URETHAN- 

THERAPIE DER LEUKÃ„MIEN. [ON THE TREATMENT 

OF LEUKEMIAS WITH URETHANE.] Aerztl. Wschr 

1948, 3: 673-675. 34 refs. 

580 Schulz, E. DIE URETHANBEHANDLUNG DER LEUKÃ„MIEN. 

[URETHANE IN THERAPY OF LEUKEMIA.] Ergebn. 

inn. Med. u. Kinderh., 1949, 1_:71-98. 

581 

Schulze, E. DIE BEHANDLUNG CHRONISCHER LEU 

KÃ„MIEN MIT URETHAN. [URETHANE TREATMENT OF 

CHRONIC LEUKEMIA.] Deut. med. Wschr., 

72: 153-157. 6 refs. Abstracted in: 

1947, 

Irfdex analyt. cancer., Par., 1948, 19: No. 

727. 

582 Schulze, E., Fritze, E. and MÃ¼ller, H. H. DIE 

WIRKUNG DES URETHANS BEI LEUKÃ„MIEN. [THE 

EFFECT OF URETHANE IN LEUKEMIA.] Deut. 

Wschr., 1947, 72: 371-377. 21 refs. 

med. 

583 

Senda, N., Inui, H., Naka, K. and Matsushita, H. 

THE URETHANE TREATMENT OF LEUKEMIA. Rinsyo 

naika syonika, 1949, 4: 457-462. 14 refs. 

In Japanese. 

584 

Serman, M. CÃ„NCER DE LENGUA RECIDIVADO TRA 

TADO CON URETANE INTRACAROTIDEO. [RECURRING 

CANCER OF THE TONGUE TREATED WITH INTRACARO- 

TID URETHANE.] DÃa mÃ©d., B. Air., 1955, 27: 

832. Intracarotid urethane injections faÃ¯Ted 

to arrest the neoplastic growth in the patient's 

tongue, but alleviated the pain. A total of 

17 cc urethane was administered. 

585 

Sherwood, F. THE USE OF URETHANE IN THE TREAT 

MENT OF LEUKEMIA. (A REVIEW OF THE LITERATURE). 

Acta haeraat., Basel, 1948, 1: 253-266. 42 refs. 

586 Siebert, W. W. ZUR URETHANBEHANDLUNG DER LEU 

KÃ„MIEN. [TREATMENT OF LEUKEMIAS WITH URE 

THANE.] Aerztl. Wschr., 1948, 3: 97-101. 

13 refs. A peroral, rectal or intravenous 

administration of urethane in 16 patients 

with acute and chronic leukemia produced 

some improvement in those with chronic leu 

kemia but almost no changes in those with 

acute leukemia. A decrease in the leucocyte 

count and in the size of the spleen as well 

as a general improvement in the overall con 

dition of the patients was observed. 

587 Srfeborg Ohlsen, A. OM URETHANBEHANDLING AF 

LEUKAEMI. [URETHANE TREATMENT OF LEUKEMIA.] 


588 Solow, S. S. LES LEUCÃ‰MIES CHEZ L'ENFANT; LE 

TRAITEMENT Ã€L'URÃ‰THANE DANS LA LEUCÃ‰MIE 

MYELOIDE AIGUÃ‹. [THE LEUKEMIAS IN CHILDREN; 

URETHANE TREATMENT IN ACUTE MYELOID LEUKEMIA.] 

31p. GenÃ¨ve, 1948. (ThÃ¨se - GenÃ¨ve) 22 refs. 

589 Spigliati, P. SUI PERICOLI DELLA TERAPIA URE- 

TANICA DELLE LEUCEMIE; LA TRASFORMAZIONE DI 

LEUCEMIA CRONICA IN ACUTA. [DANGERS OF URE 

THANE THERAPY IN LEUKEMIA; TRANSFORMATION OF 

CHRONIC LEUKEMIA INTO ACUTE LEUKEMIA.] Riv. 

clin, med., 1949, 49: 115-123. 10 refs. 

590 Stevenson, H. MULTIPLE MYELOMATOSIS; A CLINICO- 

PATHOLOGICAL REVIEW, WITH A REPORT OF A CASE 

OF MYELOBLASTIC TYPE. Postgrad. M. J., Lond., 

1948, 24: 269-282. 102 refs. See especially, 

Treatment: p. 279-280. 

591 Stock, F. E. NITROGEN MUSTARD AND URETHANE IN 

THE TREATMENT OF NASOPHARYNGEAL CARCINOMA. 

Lancet, Lond., 1951, 1: 612-613. 7 refs. 

592 

Storti, E. DIE URETHANBEHANDLUNG DER LEUKÃ„MIEN. 

[URETHANE TREATMENT OF LEUKEMIA.] Schweiz, 

med. Wschr., 1947, 77: 244. Discussion. Case 

reports. 

593 Storti, E. VALEUR DE L'URÃ‰THANE DANS LE TRAITE 

MENT DES LEUCÃ‰MIES ET D'AUTRES HÃ‰MOPATHIES. 

DEUX ANS D'EXPERIENCE CLINIQUE ET HÃ‰MATOLO- 

GIQUE. [THE VALUE OF URETHANE IN THE TREAT 

MENT OF LEUKEMIA AND OTHER HEMOPATHIES. TWO 

YEARS OF CLINICAL AND HEMATOLOGICAL EXPERIENCE.] 

Sang, Par., 1948, 19: 549-556. 8 refs. This 

study covers 42 cases treated with urethane â€¢¿ 

594 Storti, E. and Mauri, C. L'ETILURETANO NELLA 

TERAPIA DELLE LEUCEMIE; CONTRIBUTO CLINICO- 

EMATOLOGICO. [ETHYLURETHANE IN THE TREAT 

MENT OF LEUKEMIA. CLINICAL HEMATOLOGICAL 

CONTRIBUTION.] Minerva med., Tor., 1947, 

38: pt. 2, 440-448. Findings based on treat 

meht in 15 cases of leukemia. 

595 Sturgis, C. C. THERAPY IN LEUKEMIAS AND ALLIED 

DISORDERS 

10 refs. 

Postgrad. M., 1951, 9: 375-382. 

A review. 

596 Â»Suhrland, L. G. and rfeisberger, A. S. RECTAL 

ADMINISTRATION OF URETHAN IN LEUKEMIA. J. Am. 

M. Ass.. 1954, 154: 1415-1417. Abstracted 

in: Excerpta metfTT Sect. 16, 1955, 3: No. 1902. 

597 Taylor, F.M. and Geppert, L. J. CONGENITAL 

MYELOGENOUS LEUKEMIA. Am. J. Dis. Child., 

1950, 80: 417 422. 7 refs. No favorable 

therapeutic response was obtained with 

urethane. 

598 Thiersch, J. B. ASPECTS OF LEUCHAEMIA. III. 

THE TREATMENT OF LEUCHAEMIA WITH THIOURACIL 

AND URETHANE. Proc. R. Australas. Coll. 

Physicians, 1947, 2: 38-44. 8 refs. Urethane 

was beneficial in 2 of 7 cases of chronic 

myeloid leukemia and in 2 of 4 cases of chronic 

lymphoid leukemia. Thiouracil treatment was 

discontinued as unsuitable in 7 cases of chronic 

myeloid leukemia. 

599 Torrioli, M. L'URETANO ETILICO NELLA CURA DELLE 

LEUCEMIE. [ETHYL URETHANE IN THE TREATMENT 

OF THE LEUKEMIAS.] Clin, nuova, Roma, 1947, 

5: 

2, 


1949, 2: No. 2064. 

in: Excerpta med., 

"Results obtained 

Sect. 

with 

urethane 

cribed." 

Tn 18 cases of leukaemia 


are des 

600 Tortori Donati, B. and Masure, R. PREMIERS 

RÃ‰SULTATS SUR LE TRAITEMENT DES LEUCÃ‰MIES 

PAR L'URÃ‰THANE. [PRELIMINARY RESULTS OF 

THE TREATMENT OF LEUKEMIAS WITH URETHANE.] 

Acta clin, belg., 1947, 2: 142-151. 2 reÃs. 

601 Tortori-Donati, B. and Masure, R. L'URETANO 

NEL TRATTAMENTO DELLE LEUCEMIE; PRIMI 

RISULTATI TERAPEUTICI. [URETHANE IN THE 

TREATMENT OF LEUKEMIA; PRELIMINARY THERA 

PEUTIC RESULTS.] Haematologica, Pavia, 

1948, :n: 191-200. 

602 Tousek, M. PROTRAHOVANÃ‚ MYELOBLASTICKA LEUKE- 

MIE. POKUS O LECENI URETHANEM. [PROTRACTED 

MYELOBLASTIC LEUKEMIA. URETHANE TREATMENT.] 

Cas. lek. cesk., 1948, 87: 1330-1334. 19 refs. 

One case history of chronic myeloblastic 

leukemia unsuccessfully treated with urethane 

over a period of 3 months. 

Uematu, S. and Kawai, T. ONE EXPERIENCE IN THE 

TREATMENT OF CHRONIC MEDULLARY LEUKEMIA WITH 

URETHANE. Sindan and tiryo, 1948, 36: 408- 

410. In Japanese.



37 

CARBAMATE, ETHYL â€”¿ THERAPY (Continued) 

604 Van Eck, W. F. and De Vries, S. I. URETHAAN- 

BEHANDELING VAN LEUCAEMIEEN. [UKETHANE 

TREATMENT OF LEUKEMIAS.] Ned. tschr. geneesk., 


med., Sect. 7, 1949, 3: No. 2086. 

605 Viarengo, G. CASI DI LEUCEMIA TRATTATI CON 

ETILURETANO. [LEUKEMIA CASES TREATED WITH 

ETHYLURETHANE.] Minerva med.. Tor., 1949 

40: pt. 2, 294-295. 

606 Videbaek, A. OM URETHANBEHANDLING AF LEUKAEMI. 

[URETHANE THERAPY OF LEUKEMIA.] Nord, med 

1947, 33: 680-681. Abstracted in: Excerpta' 

med., Sect. 2, 1948, 1; No. 3241. 

607 

Vlados, Kh. Kh., lUrovskaia, I. I., Shamshina, 

E. V. and Shvedskii, B. P. LECHENIE KHRONI- 

CHESKIKH LEUKOZOV URETANOM. [TREATMENT OF 

CHRONIC LEUKEMIAS WITH URETHANE.] Ter. arkh., 

daily 

Moskva, 

doses 

1949, 

of~Z-6 

21: No. 

g was 

6, 

administered 

78-85. Urethane 

to 32 

in 

patients with chronic myeloid and 9 patients 

with chronic lymphoid leukemia. The treat 

ment was most successful in patients with 

myeloid leukemia and in those not previously 

treated with X-rays. 

608 

Vries, S. I. de BEHANDELINGVANACUTELEUCAEMIE. 

[THE TREATMENTOF ACUTELEUKEMIA.] Ned. tschr. 

geneesk., 1950, 94: 1619-1628. Abstracted in: 

Biol. Abstr., Barf., 1951, 25: No. 17372. 

609 Vries, S. I. de BEHANDELING VAN CHRONISCHE 

LYMPHATISCHE LEUCAEMIE MET URETHAN. [URE 

THANE TREATMENT OF LYMPHATIC LEUKEMIA.] - 

Ned. tschr. geneesk., 1953, 97: 2330-2338. 

8 refs. Abstracted in: Leukemia Abstr., 

1953, 1.:No. 385. "...the author observed 

prolonged remissions in 12 out of 14 cases 

of chronic lymphatic leukemia treated with 

urethane...The remissions, which in some 

cases lasted 24-40 months, included both 

the clinical conditions and the blood 

pictures..." - Leukemia Abstr. 

610 

WaSlschÃÃ•Z"â€¢and Cutmannova, H. LÃ‰OENÃ• 

CHRONICtÃMYELOICKÃ‰LEUKEMIE URETHANEM 

[TREATMENT OF CHRONIC MYELOID LEUKEMIA 

WITH URETHANE.] Cas. lek. fiesk.,1946 

85j 1742-1746. 2 refs. The patient, 

a female, age 22, was treated exclusive 

ly with urethane in a total amount of 73 

mg during 21 days. The size of the spleen 

diminished, the leukocyte count decreased 

and the HB rose from 54% to 93% 

611 Watkins, C. H., Cooper, T. and Giffin. H. Z. 

THE USE OF URETHANE IN THE TREATMENT OF LEU 

KEMIA; A PRELIMINARY REPORT. Blood, Bait 

1948, 3: 892-895. 

612 

Webster, J. J. URETHANE IN LEUKEMIA. J. Am. 

M. Ass., 1947, 135: 901-903. 14 refs. A 

man, aged 59, with chronic myelogenous leu 

kemia was treated first with X-rays, and 

six months later with urethane. In 3 mg 

daily doses urethane was administered over 

a period of 39 days. The drug caused se 

lective inhibition of early myeloid cells 

and a decrease in the size of the spleen. 

Patient died of granulocytopenia 14 days 

after treatment ceased. 

613 Weder, C. URETHANE IN THE TREATMENT OF MULTIPLE 

MYELOMA. 

590. rÃ©f. 

CaÃ±ad.M. 

Urethane 

Ass. 

given 

J.. 

in 

1950, 

0.5 g~capsules 

62: 589- 

daily and in total doses of 1.5 g-4 g over a 

series of treatments, produced clinical, 

histological, biochemical and hematological 

improvement after failure to arrest the disease 

with stilbamidine. 

614 

Weicker, H. LEISTUNGSFÃ„HIGKEIT UND GRENZEN DER 

MITOSEGIFT-THERAPIE BEI DEN LEUKOSEN, LYMPHO- 

GRANULOMATOSENUND MALIGNEN GESCHWULSTEN DES 

KINDESALTERS. [EFFECTIVENESS AND LIMITS OF 

THE TREATMENT WITH MITOTIC POISONS OF LEUKE 

MIA, HODGKIN'S DISEASE AND MALIGNANT TUMOURS 

IN CHILDREN.] Kinderarztl. Prax., 1950, 18: 

Sonderhft., 143-150. Bibliography: p. ~ 

150. 

615 

Weir, D. R. and Heinle, R. W. EFFECT OF URE 

THAN ON TRANSPLANTED LEUKEMIA OF AK MICE. 

Proc. Soc. Exp. Biol., N. Y., 1947, 66: 

268-270. Abstracted in: Chem. AbstrTT 1948 

42: 986ÃŒ. 

616 

Yamamoto, T. and Komatu, K. URETHANE TREAT 

MENT OF ACUTE MEDULLARY LEUKEMIA. Rinsyo 

naika syonika, 1949, 4: 164-168. rÃ©f. 

In Japanese. 

â€¢¿17 

Zwetschke, O. NASE ZKUSENOSTI S LÃ‰CENÃ•MLEU- 

KEMII. [OUR.EXPERIENCE IN THE TREATMENT OF 

LEUKEMIA.] Cas. lek. cesk., 1948, 87: 1021- 

1027. 13 refs. English summary. ''Chronic 

lymphatic and myeloid leukemia in 12 patients 

were treated with daily doses of 3-4 g ure 

thane. Nine cases were successful, 3 cases, 

mostly lymphatic leukemia,were unsuccessful. 

In 2 cases of lymphatic leukemia a rapid 

decrease of red blood cells occurred, and 

granulocytes disappeared completely from 

the peripheral blood. Both cases ended 

fatally." 

See: 

1253351099157620162259238831111334211228184920172299240532091344241252 

THERAPY, ENHANCEMENT 

618 Balduini, M. IL MIDOLLO OSSEO ED IL SANGUE 

PERIFERICO NELLA INTOSSICAZIONE SPERIMENTALE 

CON URETANO ETILICO. [THE BONE MARROW AND 

THE PERIPHERAL BLOOD IN EXPERIMENTAL ETHYL 

URETHANE POISONING.] Haematologica, PavÃa, 

1949, 33: 55-70. 30 refs. English summary. 

619 

Bertrand, I. and (Juivy, D. LÃ‰SIONSEXPERIMEN 

TALES OBSERVÃ‰ES CHEZ LE LAPIN APRÃˆSURÃŠTHANE. 

[EXPERIMENTALLESIONS OBSERVEDIN THE RABBIT 

AFTER URETHANE.] C. rend. Soc. biol., 1950, 

Ã„T5s~tr., 

144: 482-483. 

1951, 45: 

1 rÃ©f. 

261h. 


Bertrand, I. and Quivy, D. SUR LES LÃ•SIONSEX 

PÃ‰RIMENTALES OBSERVEESCHEZ LE RAT APRES URE 

THANE. [EXPERIMENTALLESIONS OBSERVEDIN RATS 

GIVEN URETHANE.] C. rend. Soc. biol., 1950, 


IbTtr., 1951, 45: 261g. 

See: 

693 

OF



38 

CARBAMATE, 

ETHYL â€”¿ TOXJCITY 

621 

Bertrand, I. and Quivy, D. SUR LES LESIONS 

TARDIVES OBSERVEES CHEZ LE RAT APRES INJECTIONS 

D'URETHANE. [ON TARDY LESIONS OBSERVED IN THE 

RAT FOLLOWING INJECTIONS OF URETHANE.] C. 

rend. Soc. biol., 1952, 146: 638-640. 7 rets. 

Ethylurethane in daily doses oÃ 0.4 mg was 

injected intraperitoneally into female rats. 

Aside from hemorrhagic alveolitis, various 

histological changes in the liver, spleen and 

lungs were observed not only in the mice 

treated with urethane but also in their litters. 

622 

Bottner, H. TÃ–DLICHE APLASTICHE ANÃ„MIE NACH 

URETHAN-BEHANDLUNG EINER MYELOISCHEN LEU 

KÃ„MIE. [FATAL APLASTIC LEUKEMIA FOLLOWING 

URETHANE TREATMENT OF MYELOID 

Med. Klin., Munch., 1948, Â«: 

LEUKEMIA.] 

636-638. 

4 refs. 

623 

Brugsch, J. ÃœBER LEUKOZYTENVERÃ„NDERUNGEN UND 

TOXISCHE SPÃ„TPORPHYRINURIE BEI CHRONISCHEN 

MYELOISCHEN LEUKÃ„MIE DURCH ZELLGIFTE (MITO 

SEGIFTE) BEIM MENSCHEN. [MORPHOLOGICAL 

CHANGES IN THE LEUCOCYTES AND DELAYED TOXIC 

PORPHYRINUHIA IN CHRONIC MYELOGENOUS LEU 

KEMIA DUE TO MITOTIC POISONS IN MAN.] Zschr. 

ges. inn. Med., 1947, 2: 273-275. 18 refs. 

624 

Eskola, 0. A CASE OF ALEUCIA HEMORRHAGICA 

(FRANK) AND PAN-MYELOPHTHISIS POSTERIOR TO 

URETHANE TREATMENT IN LEUKEMIA. Acta med. 

scand., 1949, 133: 261-267. 11 refs. 

625 

Goldeck, H. and Muller, E. F. DIE ERYTHROTOXISCHE 

URETHANWIRKUNG BEI DER LABORATORIUMSRATTE. 

[ERYTHROTOXIC ACTION OF URETHANE IN RATS.] 

Aerztl. Forsch., 1950, 4: Originalarb., 192-196. 

12 refs. Abstracted in: Excerpta med., Sect. 2, 

1950, 3: No. 5787. 

626 Orafe, G. TOXISCHE PORPHYRINURIE NACH URETHAN- 

BZW. COLCHICINBEHANDLUNG. [TOXIC PORPHYRIN- 

URIA FOLLOWING URETHANE AND COLCHICINE TREAT 

MENT]. Deut. Gesundhwes., 1948, 3: 50-52. 

16 reÃs. 

627 

Hallgren, ,.L i gÃ¬c u - Bâ€žE. DO e. j URETHANE u Ar, i ruiiiri TOLERANCE i UL r, n mi*./r, TESTS if>oi o IN i ii 

LEUKEMIA PATIENTS. Acta med, scand., 1950, 


- 1951, 45: 5294ÃŒ. 

628 

Hazlett, B. E., Taylor, H. E. and Whitelaw, 

D. M. FULMINATING HEPATIC NECROSIS IN A 

PATIENT WITH MULTIPLE MYELOMA TREATED WITH 

URETHANE; REPORT OF CASE. Blood, Bait., 

1955, 10: 76-80. 6 refs. 

629 

Klima, R. and Wengraf, G. SCHÃ„DIGUNGEN DES 

ZENTRALNERVENSYSTEMS DURCH URETHAN. [URE 

THANE INDUCED DAMAGE OF THE CENTRAL NER 

VOUS SYSTEM]. Wien. med. Wschr., 1949, 


C"Ã¯Ã¯em. Abstr., 1949, 43: 5498e. 

630 

Markoff, N. UEBER KRISTALLBILDUNG IN DER HORN 

HAUT BEI URETHANTHERAPIE DES MYELOMS. [CRYS 

TAL FORMATION IN THE CORNEA FOLLOWING URE 

THANE TREATMENT OF A MYELOMA.] Schweiz, med. 

Wschr., 1948, 713: 987-988. 

631 Meacham, G. C., Tillotson, F. W. and Heinle, 

R.W. LIVER DAMAGE AFTER PROLONGED URETHANE 

THERAPY. Am. J. Clin. Path., 1952, 22: 22- 

27. 14 refs. 

632 

Moeschlin, S. and Bodmer, A. AGRANULOCYTOSE 

ET PANMYELOPATHIEXPERIMENTALESÃ€L'URETHANE 

CHEZ LE CHAT. [EXPERIMENTALURETHANEAGRANU- 

LOCYTOSIS AND PANMYELOPATHYIN CATS]. Sang, 

Par., 1950, 21: 515-516. Abstracted in: 

Chem. Abstr., 1950, 44:.9069i. 

633 

Millier, A. H. GRENZEN DER URETHANBEHANDLUNG 

MYELOISCHER LEUKÃ„MIEN. [LIMITATIONS 0F 

URETHANE THERAPY OF MYELOID LEUKEMIA.] 

Deut. med. Wschr., 1949, 74: 667-670. 

Approx. 45 refs. 

634 Â»Ohler, H. L., Houghton, J. D. and Moloney, W. C. 

URETHAN TOXICITY. REPORT OF A CASE OF HEPATIC 

NECROSIS APPARENTLY DUE TO URETHAN. N. England 

J. M., 1950, 243: 984-988. Abstracted in: 

Excerpta med.7~S"ect. 2, 1951, 4: No. 6942; 

Chem. Abstr., 1951, 45: 77011. 

633 

Ravina, A., MallarmÃ©, J. and Nory, J. LEUCÃ‰MIE 

MYÃ‰LOIDE D'Ã‰VOLUTION DÃ‰JÃ€ANCIENNE TRAITÃ‰E 

PAR L'URETHANE. TRANSFORMATION MYÃ‰LOBLASTIQUE 

TRÃˆS RAPIDE SURVENUE AU COURS DU TRAITEMENT. 

[MYELOID LEUKEMIA OF LONG STANDING TREATED 

WITH URETHANE. RAPID MYELOBLASTIC TRANSFORMA 

TION DURING TREATMENT.] Bull. Soc. mÃ©d. hop. 

Paris, 1948, 64: 1114-1116. Discussion: 

p. 1116-1117. Abstracted in: Index analyt. 

cancer., Par., 1950, 2U No. 248. 

636 

Reissmann, G. and Krug, K. UNERWÃœNSCHTE NEBEN 

WIRKUNGEN BEI BEHANDLUNG MIT XTHYLURETHAN. 

[UNDESIRABLE SIDE EFFECTS OF URETHANE TREAT- 

BENT.] Deut. Gesundhwes., 1950, 5: 102-107. 

24 refs. English summary. Total doses of 

90-144 g of urethane caused severe agranulocytosis. 

637 Rosin, A. EARLY CHANGES IN THE LUNGS OF RATS 

TREATED WITH URETHANE. (ETHYL CARBAMATE). 

Cancer Res., 1949, 9: 583-588. "Prolifera 

tion of the epithelTal cells of the lung was 

observed in rats treated with daily intraperitoneal 

injections of urethane. Adenomatous 

and papillomatous formations were 

microscopically observed as early as 4 to 

13 days after the first injection. The 

histology of these early changes is des 

cribed and their histogenesis discussed." 

638 Skipper, H. E., Bryan, C. E., Riser, W. H., Jr., 

Welty, M. and Stelzenmuller, A. CARBAMATES 

IN THE CHEMOTHERAPY OF LEUKEMIA. II. THE 

RELATIONSHIP BETWEEN CHEMICAL STRUCTURE, 

LEUKOPENIC ACTION, AND ACUTE TOXICITY OF A 

GROUP OF URETHAN DERIVATIVES. J. Nat. Cancer 

Inst., 1948, 9: 77-88. 4 refs. 

639 Voit, K. and Hodeige, H. J. EXPERIMENTELLE 

UNTERSUCHUNGEN ÃœBERDIE URETHANWIRKUNGBEI 

WEISSEN RATTEN. [EXPERIMENTAL STUDIES ON THE 

ACTION OF URETHANE ON VKHITERATS.] Med. Klin., 

Beri., 1949, 44: 1115-1116. 9 refs. 

640 

Voit, K. and Hodeige, H. J. NUCLEALSTUDIEN 

BEI EXPERIMENTELLER URETHANVERGIFTUNG. 

[STUDIES ON NUCLEI IN EXPERIMENTAL INTOXI 

CATION WITH URETHANE.] Aerztl. Forschung., 

1949, 3: originalarb., 387-389. Abstracted 


641 

Winchester, W. W. and Higgins, G. M. PULMONARY 

EDEMA IN LEUCEMIC MICE FOLLOWING TREATMENT 

WITH URETHANE. Science, 1948, 107: 568-569. 

7 refs. 

See: 

340 567 2107 1056a



39 

CARBAMATE, ETHYL â€”¿TOXICITY, COUNTERACTION 

TO 

642 Riegel, R. URETHAN UND HYALURONIDASE. DIE 

VERWENDUNGVON HYALURONIDASE BEI DER INTRA 

MUSKULÃ„RENAPPLIKATION VON URETHAN. VOR 

LÃ„UFIGE MITTEILUNG. [USE OF HYALURONIDASE 

IN INTRAMUSCULAR ADMINISTRATION OF URETHAN. 

PRELIMINARY COMMUNICATION.] Deut. med. 

Â«sehr., 

Excerpta 

1953, 78: 

med.,~Sect. 


2, 1954, 7: No. 

in: 

2734. 

CARBAKATE, 

PHENYL- 

643 

Crick, J. and Jackson, H. A TRACER STUDY OF 

THE METABOLISM OF P-IODOPHENYL URETHANE; THE 

SELECTIVE LOCALIZATION OF RADIOACTIVE MATERIAL. 

Brit. J. Pharmacol., 1952, 7: 142-151. 10 refs. 

644 

Fornara, P. LEUCEMIE INFANTILI TRATTATE CON 

FENILURETANO. [PHENYL CARBAMATE TREATMENT OF 

LEUKEMIA IN CHILDREN.] Minerva med., Tor., 

1949, 40: pt. 2, 293-294. 

645 

Pekhtereva, S. I. VLIIANIE FENILURETANA NA 

ROST RAKA ERLIKHA U MYSHEI. [EFFECT OF 

PHENYLURETHANE ON GROWTH OF EHRLICH CARCI 

NOMA IN MICE.] Biull. eksp. biol. med., 

1954, 37: No. 2, 65-67. 1 reÃ. Daily 

subcutaneous injections of 10 mg phenylurethane 

caused inhibition of Ehrlich carci 

nomas in 86 mice. Tumor growth regression 

was observed only during drug administra 

tion. Phenylurethane given with arginine 

markedly reduced the cancerogenic effects 

of the latter. 

646 

Sentein, P. LA RESTAURATION DE L'APPAREIL 

ACHROMATIQUE APRES SA DÃ‰POLARISATION PAR 

LES SUBSTANCES ANTIMITOTIQUES. [RESTITU 

TION OF THE ACHROMATIN COMPLEX AFTER ITS 

DEPOLARIZATION BY ANTIMITOTIC COMPOUNDS.] 

C. rend. Ass. anat., 1950, 37: 462-470. 

9 refs. Detailed description of the mode 

of action of phenylurethane on the cells 

of the egg of Triturus helveticus Raz, 

during segmentation. 

See: 

1288 

CARBAMATE, 

2-THIO- 

647 Powell, A. K. EFFECT OF DITHIOCARBAMATES ON 

SARCOMA CELLS AND FIBROCYTES CULTURED IN 

VITRO. Brit. J. Cancer, 1954, 8: 529-534. 

2 pi. 13 refs. 'The toxicities of piperidinium 

pentamethylene-, sodium pentamethylene-, 

and sodium diethyldithiocarbamates to sarcoma 

cells and embryonic mouse fibrocytes cultured 

in vitro have been studied. Sodium diethyldithiocarbamate 

is the least toxic of these 

compounds and is more toxic to sarcoma cells 

than fibrocytes in rapidly growing cultures. 

It is suggested that this property may be 

related to the reported effects of this com 

pound on oxidation-reduction systems and 

cellular respiration." 

CARBAMATES 

648 

Skipper, H. E. and Bryan, C. E. CARBAMATES IN 

THE CHEMOTHERAPY OF LEUKEMIA. III. THE RE 

LATIONSHIP BETWEEN CHEMICAL STRUCTURE AND 

ANTI-LEUKEMIC ACTION OF A SERIES OF URETHAN 

DERIVATIVES. J. Nat. Cancer Inst., 1949, 9: 

391-397. 25 refs. Abstracted in: Chem. AEstr 

1949, 43: 6737a. 

649 

Vartiainen, L. and Vartiainen, o. URETHAN 

DERIVATIVES IN LEUKEMIA. Ann. med. int. 

fenn., 1950, 39: 205-210. tab. rÃ©f. 

650 

Winchester, W. W. THE EFFECT OF URETHANE AND 

SEVERAL URETHANE DERIVATIVES ON TRANSPLANTED 

MYELOGENOUS LEUKEMIA IN THE MOUSE. 217 t. 

16 pl. Minnesota, 1952, Thesis-Univer. Minn. 

(Typewritten). 189 refs. A report on leuke 

mia and 3 of its derivatives, 2,4-oxazolidinedione(Misc.-20), 

isopropyl carbamate(D-93) 

and ethyl N-methylcarbamate(D-94). "All were 

inferior to urethane in prolonging the lives 

of animals with myelogenous leukemia, or in 

producing hÃ©matologie remissions of their 

disease. Though apparently not as hepatotoxic 

as other drugs tested, urethane exhibi 

ted a specific toxic effect on the capillaries 

as evidenced by pulmonary edema. This com 

plication of its administration proved to be 

the limiting factor in accomplishing satis 

factory treatment. It was not possible to 

discover a satisfactory dosage or method of 

administration that was adequate to control 

the leukemic process without producing pul 

monary edema." 

See 

1288 

CARYOMYCIN 

651 

Okami, Y., Okuda, T., Takeuchi, T., Nitta, K. 

and Umezawa, H. STUDIES ON ANTI-TUMOR SUB 

STANCES PRODUCED BY MICROORGANISMS. IV. 

SARKOMYCIN-PRODUCING STREPTOMYCES AND TWO 

OTHER STREPTOMYCES PRODUCING THE ANTI-TUMOR 

SUBSTANCE NO. 289 AND CARYOMYCIN. J. Anti 

biotics, Ser. A, Tokyo, 1954, 7: 1953, 6: 

153-157. 

CARZINOPH1LIN 

652 

HÃ¢ta, T., Koga, F., Sano, Y., Kanamori, K., 

Matsumae, A., Sugawara, R., Hoshi, T., 

Shima, T., Ito, S. and Tomizawa, S. 

CARZINOPHILIN, A NEW TUMOR INHIBITORY SUB 

STANCE PRODUCED BY STREPTOMYCES. I. 

J. Antibiotics, Ser. A, Tokyo, 1954, 7: 

107-112. 5 refs. In English. Carzinophilin 

showed antibacterial activity against gram 

positive bacteria particularly S. lutea, and 

brought about destruction of tumor cells and 

prolongations of life in animals inoculated 

with Yoshida sarcoma, Ehrlich carcinoma and 

ascetic hepatoma of 7974 strain. 

653 Koga, F. EXPERIMENTALTREATMENTOF MALIG 

NANTTUMORWITH ANTIBIOTICS. II. EXPER 

IMENTALTREATMENTWITH A NE* ANTIBIOTIC, 

CARZINOPHILIN. J. Antibiotics, Ser. A, 

1954, 7:176-177. 

CARZODELAN 

see ENZYMES, 

CATHARTICS 

PROTEOLYTIC 

654 Belkin, M. and Fitzgerald, D. B. TUMOR-DAMAGING 

CAPACITY OF PLANT MATERIALS. I. PLANTS USED 

AS CATHARTICS. J. Nat. Cancer Inst., 1952, 

13: 139-155. 3 pi. 13 refs. 

CB1348 

see NITROGEN MUSTARDS. BUTYRIC ACID, N, N-DI-2- 

CHLOROETHYL-p-AMCNOPHENYL-



40 

CELL 

THERAPY 

655 

Niehans, P. ZELLEN IM KAMPFE GEGEN KREBS. [COM 

BATTING CANCER WITH CELLS.] In his: DIE ZELL 

ULARTHERAPIE. UUnchen, Urban & Schwarzenberg, 

1954, p. 358-405. 37 refs. The chapter treats 

of cell therapy in cancer. Fresh cells from 

various organs were injected into patients 

with different types of cancer. General im 

provement of the overall condition occurred 

with regression in some of the tumors. 

656 

Â»Reichle, P. FRISCHZELLENTHERAPIE UND CARCINOM- 

BEHANDLUNG. [THE FRESH-CELL THERAPY AND 

TREATMENT OF CARCINOMA.] Sudwestdeut. Ã„rztebl., 

1954, 9: No. 4, 77-78. Abstracted in: RÃ©f. 

zh. Blol., 1955, No. 9924. 

657 

Robert, A. G. S. VORLAUFIGER BERICHT ÃœBER DIE 

BEHANDLUNG VON KREBSMETASTASEN MIT FRISCHZELLEN. 

[PRELIMINARY REPORT ON THE TREATMENT OF CANCER 

METASTASES WITH FRESH CELLS.1 Med. Klin., 

Beri., 1953, 48: 1080. One male patient, age 

59, with many cancerous mÃ©tastases and advanced 

prostate cancer was treated with fresh cells 

and placenta and testis extracts. The mÃ©ta 

stasÃ©e stopped spreading and bone calcification 

of the pelvic region became more pronounced. 

653 Weiss, K. H. ERFAHRUNGEN MIT DER FRISCHZELLEN- 

THERAPIE BEI MALIGNEN TUMOREN. [EXPERIENCES 

WITH FRESH-CELL THERAPY IN MALIGNANT TUMORS.] 

In: Beitrage fur Zellulartherapv: Thun, Schweiz, 

Ott, 1952, 119-124. Animal fresh cells were 

administered to 7 patients with various malig 

nant cancers. In advanced cancer patients this 

therapy was not successful. X-ray therapy in 

conjunction with cell therapy did not prove 

effective, because the x-rays damaged the 

fresh cells. 

CEPHALJN 

659 

KySarovas, M. KANCEROLIZINIS KEFALINO VEIKIMAS. 

[THE CANCEROLYTIC EFFECT OF CEPHALIN.) Tr. 

Akad. nauk Latv. SSR. Inst. eksp. med. onkol., 

1953, 2: 167-181. Cephalin destroyed the 

cells of transplanted mouse Crocker sarcoma 

and Ehrlich adenocarcinoma, but did not affect 

the cells of benign tumors or normal tissue. 

CHALMOOGRIC PEROXIDE 

660 

Lefevre, R., Baranger, P. and Pariset. ESSAI 

DE TRAITEMENT DES TUMEURS CANCÃ‰REUSES PAR 

UN DÃ‰RIVÃ‰CHAULMOOGRIQUE. [TRIAL 0F CANCER 

TREATMENT WITH A CHAULMOOGRA DERIVATIVE.] 

Acta UniÃ³ internat, cancr., Louvain, 1953, 

9: 101-104. 

CHELIDONTUM 

MAJUS 

661 â€ž¿ 

Balits'kiÃ¯. K. P. PRO ANTIBLASTICHNU DIIU 

CHISTOTILA. [ANTIBLASTIC EFFECT OF CHEH- 

DONIUM MAJUS.] Med. Zh., Kiev, 1953, 23: 

No. 3, 69-75. 13 reÃs. Extract of ChÃ¨Tidonium 

majus in doses of 10 ml. was in 

jected subcutaneously and intratumorally 

to 22 rats and 5 rabbits with transplanted 

adenocarcinoma and sarcoma. Necrosis of 

tumor tissue and frequently complete tumor 

regression was observed. 

662 

Svejda, J. UCINEK VYTAZKU Z VLAÂ§TOVlCNÃ•KU 

VÃ‰TSÃ•HONA CROCKERUV NÃ•DOR. [THE EFFECT OF 

CHELIDONIUM EXTRACT ON THE CROCKER SARCOMA.] 

Cas. lek. Â¿esk., 1949, 88: 1428-1429. Aqueous 

extract of Chelidonium magnum in a concen 

tration of 1:50 delays development and sub 

sequently inhibits growth of Crocker sarcoma 

but with the concentration used complete 

inhibition of tumor growth was not effected. 

The inhibiting effect is not diminished by 

either heat or cold. 

663 

Svejda J. UCINEK VYTAÃ•5KUZ VLASTOVICNÃ•KU 

VETSIIIO NA MALIGNÃ• MYSÃ• EPITHELIUM. [ACTION 

OF AN EXTRACT OF CHELIDONIUM ON MALIGNANT 

EPITHELIOMA OF THE MOUSE.) Cas. lek. cesk., 


med., Sect. 5, 1949, 2: No. 790. 

CHLORAL 

664 Sentein, p. ACTION DE LA COLCHICINE ET DE 

L'HYDRATE DE CHLORAL SUR L'OEUF DE TRITURUS 

HELVETICUS L. EN DÃ‰VELOPPEMENT. [THE EFFECT 

OF COLCHICINE AND CHLORAL HYDRATE ON THE 

GROWTH OF THE EGG OF TRITURUS HELVETICUS L.l 

Acta Anat., Basel., 1947, 4: 256-258. 

665 Sentein, P. ACTION COMPARÃ‰E DE LA COLCHICINE 

ET DU CHLORAL SUR LE DEVELOPPEMENT DES OEUFS 

D'AMPHIBIENS ANOURES. [COMPARATIVE ACTION 

OF COLCHICINE AND CHLORAL ON THE DEVELOPMENT 

OF EGGS OF ANURIAN AMPHIBIANS.] C. rend. 

Soc. biol., 1947, 141; 352-354. 9 reÃs. 

Abstracted in:.Chem. Abstr., 1948, 42: 68od. 

666 Sentein, P. SUR L'ACTION COMPARÃ‰E DE LA 

COLCHICINE ET DU CHLORAL SUR LES CELLULES 

EPITHELIALES ET NERVEUSES DE LARVES D'AMPHI 

BIENS. [COMPARATIVE EFFECT OF COLCHICIilE 

AND CHLORAL ON THE EPITHELIAL AND NERVE CELLS 

OF AMPHIBIA LARVA.] C. rend. Ass. anat., 

1947, 3j4: 440-451. 17 refs. 

667 

Sentein, P. ACTION COMPARÃ‰E DE SUBSTANCES ANTI 

MITOTIQUES SVR LA SEGMENTATION ET LA GASTRU- 

LATION CHEZ LES ANOURES. [COMPARATIVE STUDY 

OF THE EFFECT OF ANTIMITOTIC SUBSTANCES ON 

SEGMENTATION AND GASTRULATION IN ANURA.] C. 

rend. Soc. biol., 1948, 142: 206-208. Ã³reÃs. 

Abstracted in: Excerpta med., Sect. 2. 1949, 

2: No. 11. 

See: 

81 798 

CHLORAMINE 

see NITROGEN. MUSTARDS. ETHYLAMINE, METHYL 

BIS-(B-CHLORO- 

CHLORAMPHENICOL â€”¿ EFFECT ON MALIGNANT 

GROWTH 

668 Le Page, G. A. EFFECTS OF CHLORAMPHENICOL ON 

INCORPORATION OF GLYCINE-2-C14 INTO MAMMALIAN 

TUMOR CELL 

Exp. Biol., 

PROTEINS AND PURINES. Proc. 

N. Y., 1953, 83: 724-726. 

Soc. 

Ab 

stracted in: Excerpta med., Sect. 16, 1954, 

2: No. 3058; Chem. Abstr., 1954, 48: 276h. 

669 

Levaditi, C. and Vaisman, A. ACTION DE LA CHLO- 

ROMYCÃ‰TINE (CHLORAMPHENICOL) ET DE L'AURÃ‰OMY- 

CINE SUR LE VIRUS LYMPHOGRANULOMATEUX (MALADIE 

DE NICOLAS-FAVRE). [ACTION OF CHLOROMYCETIN 

(CHLORAMPHENICOL) AND AUREOMYCIN ON THE VIRUS 

OF LYMPHOGRANULOMATOSIS (NICOLAS-FAVRE DISEASE).] 

C. rend. Acad. se., 1949, 'Â¿29:1274-1276. 

"Chloromycetin and aureomycln exert a thera 

peutic effect on mice infected with the virus 

of lymphogranulomatosis. However, the effect 

of aureomycin is distinctly superior to that 

of Chloromycetin. These conclusions are in 

agreement with those of Wong and Cox." 

THERAPY 

670 

Krakoff, I. II,,.Karnofsky, D. A. and Burchenal, 

J. H. EFFECTS OF LARGE DOSES OF CHLORAMPHENI 

COL ON HUMAN SUBJECTS. N. England J. M., 1955, 

253: 7-10. 32 refs.



41 

CHLORAMPHENICOL â€”¿THERAPY (Continued) 

671 Lonati, II. L. CONTRIBUTO CLÃ•NICO ALLA FASE DI 

REMISSIONE DELLA LEUCEMIA ACUTA. [CLINICAL 

CONTRIBUTION TO THE STUDY OF REMISSIONS IN 

ACUTE LEUKEMIA.] Minerva pediat., Tor., 1950, 

2: 284-285. 

672 

Macciotta, G. CONSIDERAZIONI SULLE MODIFICA 

ZIONI PROVOCATE DAL CHLOROAMFENICOLO IN DUE 

CASI DI LINFOADENOSI LEUCEMICA LEUCOPENICA 

IN BAMBINI. [CONSIDERATIONS ON THE INFLUENCE 

Of CHLORAMPHENICOL IN 2 CASES OF LEUCOPENIC 

LYMPHATIC LEUKEMIA IN CHILDHOOD,] 

paediat. lat., 1953, 6: 386-402. 

Acta 

Approx. 

30 refs. Abstracted Ih: Excerpta med., 

Sect. 16, 1954, 2: No. 4442. 

CHLORAZOL FAST PINK 

673 

Ferrari, W. and Costa, E. SU DI UNA ATTIVITÃ€ 

ANTITUMORALE DEL CHLORAZOL FAST PINK(C.F.P.). 

I. INFLUSSO DEL C.F.P. SUL SARCOMA DA 

BENZOPIRENE E SULL'ACCRESCIMENTO DI SARCOMI 

DA INNESTO. [ANTITUMORAL ACTIVITY OF CHLO 

RAZOL FAST PINK. I. INFLUENCE ON THE BENZO- 

PYRENE SARCOMA AND ON THE GROWTH OF TRANS 

PLANTED SARCOMA.] Tumori, Milano, 1950, 36: 

293-303. 16 refs. 

CHLORIDES 

674 Taylor, A. and Carmichael, N. THE EFFECT OF 

METALLIC CHLORIDES ON THE GROWTH OF TUMOUR 

AND NONTUMOR TISSUE. Univ. Texas Pubi. 

Biochem. Inst. Stud., 1953, No. 5314, 36- 

79. 26 refs. Thirty-three metallic chlo 

rides and 4 metallic nitrates are tested in 

varying dosages for effects on growth and 

survival of chick embryos and eggs, bearing 

yolk sac implants of mouse mammary adenocarcinoma, 

and for effects on sarcoma trans 

plants in mice(DBA 131). The chlorides of 

aluminum, beryllium, cerium, copper, lithium, 

rhodium, thalium and zirconium, and lead and 

silver nitrate inhibited growth in eggs with 

little or no effect on the growth of the 

host embryo. The chlorides of cobalt, copper, 

mercury, nickel, rhodium, rubidium, thalium, 

and zinc, and silver nitrate had the most 

inhibiting effect on the growth of trans 

plants of the sarcoma. 

CHLOROFORM 

See: 

85 

CHLOROMYCETIN 

see CHLORAMPHENICOI, 

CHLOROPHYLL 

See: 

15 

CHLORTETRACYCLINE â€”¿EFFECT ON MALIGNANT 

GROWTH 

675 

Sokoloff, B. and Eddy, W. H. EFFECT OF AUREO- 

MYCIN ON TRANSPLANTED TUMORS. A.M.A. Arch. 

Path., 1951, 52: 210-214. 4 refs. 


676 

Bateman, J. C., Cornman, I., Orice, P. M., 

Kennelly, J. M., Jr. and Klopp, C. T. COM 

BINED ADMINISTRATION OF AUREOMYCIN AND NITRO 

GEN MUSTARD. I. ANIMAL AND TISSUE CULTURE 

EXPERIMENTS. Cancer, Phila., 1953, 6: 275- 

279. 11 refs. 

See: 

669 3372 

THERAPY 

677 

Ayre, J. E. REGRESSION OF ANAPLASTIC LESIONS 

(CARCINOMA IN SITU) OF THE CERVIX USING AUREO 

MYCIN; A PRELIMINARY REPORT OF SIX RESPONSIVE 

CASES. Antibiotics & Chemotherapy, 1951, 1: 

339-357. 10 refs. 

678 

Ayre, J. E. REGRESSION OF CERVICAL CARCINOMA 

IN SITU FOLLOWING AUREOMYCIN; FURTHER REPORT. 

South. M. J., 1952, 45: 915-921. Discussion 

p. 620-621. 

679 

Barberio, R., Berry, N., Bateman, J., Cromer, 

J. K. and Klopp, C. T. COMBINED ADMINISTRA 

TION OF AUREOMYCIN AND NITROGEN MUSTARD. II. 

EFFECTS OF THE INTRA-ARTERIAL ADMINISTRATION 

ON HUMAN CANCER. Cancer, Phila., 1953, 6: 

280-287. 15 refs. 

680 

Bateman, J. C., Donlan, C. P., Klopp, C. T. 

and Cromer, J. K. COMBINATION PARENTERAL 

AUREOMYCIN AND IRRADIATION IN FAR ADVANCED 

CANCER], Am. J. Roentg., 1955, 74: 123-129. 

24 refs. 

681 Brown, S. R. HODGKIN'S DISEASE CONTROLLED BY 

CHLOROMYCETIN; REPORT OF A CASE. Hawaii M. J. 

1951, 10: 356-357. 

682 

Coste, F., Delbarre, F. and Bourel, M. SUR UN 

CAS DE MYELOME MULTIPLE DES OS HEMOHISTIO- 

BLASTOPLASMOCYTAIRE TRAITÃ‰ PAR L'AURÃ‹OMYCINE. 

[A CASE OF MULTIPLE MYELOMA OF THE HEMOHISTO- 

BLASTOPLASMOCYTIC BONE TREATED WITH AUREOMYCIN. 

Rev. rhumat., Par., 1950, 17: 569-572. Aureomycin 

in daily doses of 2 g was given orally. 

Within one month the overall condition of the 

patient generally improved, the blood picture 

became normalized, the pain in the bones dis 

appeared. Roentgenologically no changes were 

observed. Two other cases of multiple myeloma 

treated with aureomycin showed no improvement. 

683 

Goldman, R. THE EFFECT OF AUREOMYCIN UPON 

HODGKIN'S DISEASE. Am. J. M. Se., 1951, 

221: 195-198. 5 refs. "Five patients in 

Varying stages of Hodgkin's disease, but 

all with fever, were given standard doses 

of aureomycin without any apparent altera 

tion in their clinical course." 

684 

Huth, E. F. BEITRAG ZUR THERAPIE DER AKUTEN 

LEUKÃ„MIE. [THERAPY OF ACUTE LEUKEMIA). 

Zschr. Kinderh., 1953, 74: 20-29. 44 refs. 

685 

Plauchu, [M], Revol, [L], Morel, [A], Chavanis, 

[P] and Mouriquand, [C] INTÃ‰RÃŠTDE L'AURÃ‰O- 

MYCINE DANS LE TRAITEMENT DES LEUCÃ‰MIES. 

[IMPORTANCE OF AUREOMYCIN IN THE TREATMENT 

OF LEUKEMIA.] Lyon mÃ©d., 1951, 184: 184-186. 

686 

Weicker, H. and Schreier, K. DIE LEUKOSEN DES 

KINDES UNTER STILBOESTROL, AMINOPTERIN UND 

AUREOMYCIN. [LEUKEMIA IN CHILDREN TREATED 

BY STILBESTROL, AMINOPTERIN AND AUREOMYCIN.] 

Zschr. ges. inn. Med., 1952, 7: 81-89. 

51 refs. Abstracted in: Leukemia Abstr., 

1953, 1: No. 125.



42 

CHLORTETRACYCLINE 

2321 


(Continued) 

CHOLINE 

687 llarcolongo, V. L'AZIONE DELLA COLINA SULLA 

STEATOSI E SULLO SVILUPPO DEI FIBROBLASTI 

COLTIVATI IN 

ON STEATOSIS 

VITRO. [THE ACTION OF CHOLINE 

AND THE DEVELOPMENT OF FIBRO- 

BLASTS CULTIVATED IN VITRO.] Oncologia, 

Roma, 1949, 23: 103-106. Abstracted in: 

Excerpta medTT Sect. 5, 3: 1950. 

fi ft fi 

Seekfort, H. and Weise, J. STOFFWECHSELUNTER 

SUCHUNGEN BEI INTRAVENÃ–SER CHOLINTHERAPIE. 

V VERÃ„NDERUNGEN DER ZELLELEMENTE DES BLUTES 

NACH INTRAVENÃ–SER ZUFUHR VON HETHIONIN UND 

CHOLIN. [METABOLIC RESEARCH WITH INTRAVENOUS 

CHOLINE THERAPY. V. CHANGES IN THE BLOOD 

CELLS AFTER INTRAVENOUS ADMINISTRATION OF 

CHOLINE AND METHIONINE.] Klin. Wschr., 1951, 

29: 294-295. Treatment produced an increase 

In the granulocyte count and a fall in the 

leucocyte count. No structural changes in 

the blood cells occurred. 

689 Veiten. ZUR MORPHOLOGIE DER CHOLIN-THERAPIE 

BÃ–SARTIGER GESCHWULSTE. [TREATMENT OF MALIG 

NANT GROWTHS WITH CHOLINE. MORPHOLOGY. Zbl. 

allg. Path., 1949, 85: 115. Abstracted in: 


THERAPY 

690 Becker. J. CHOLINTHERAPIEBEI MALIGNENTUMOREN. 

[CHOLINE IN CANCERTHERAPY.] Strahlentherapie, 

1949, 80: 85-94. 43 reÃs. 

691 Becker, J. CHOLINUM CHLORATUM ALS SELBSTÃ„NDIGES 

CHEMOTHERAPEUTICUM BEI MALIGNEN TUMOREN. [CHO 

LINE CHLORIDE AS AN INDEPENDENT CHEMOTHERAPEuTIC 

AGENT IN MALIGNANT TUMORS.] Zschr. Krebsforsch., 

1948, 56: 171-175. Report on the treatment of 

various~malignant tumors with choline chloride. 

The daily doses varied from 5 to 15 g. given 

intravenously or by a duodenal or rectal tube. 

The treatment, repeated after an interval of 

three months to prevent recurrences, caused 

regression of primary tumors and mÃ©tastases. 

692 Fecht, K. E. BEITRAG ZUR CHOLINTHERAPIE BEIM 

CARCINOM. [CHOLINE IN CANCER THERAPY.] 

Strahlentherapie, 1949, 80: 95-98. 

693 Ganssien, M. FORTSCHRITTE IN DER BEHANDLUNG VON 

TUMOREN LEUKÃ„MIEN UND GRANULOMEN. [ADVANCES 

IN THE TREATMENT OF TUMORS, LEUKEMIAS AND 

GRANULOMAS.] Strahlentherapie, 1950, 83: 

183-197. Chloride of choline in doses of 

1.5-6.0 g, and the sulfonamide eleudron in 

doses of 75-600 mg. were both administered 

orally to 100 patients with inoperable can 

cer. The treatment was most successful in 

cancer of the pancreas. Within 4 months com 

plete rÃ©sorption of the tumor tissue occurred. 

Improvement in the overall condition and a 

prolongation of life was observed in patients 

with chronic lymphoid leukemia. Choline 

furthers the effects of chloroethylamines, 

urethane and X-ray therapy when administered 

simultaneously with these agents. 

69Kraus, H. H. UNSERE ERFAHRUNGEN MIT CHOLINZITRAT 

IN DER THERAPIE DER INOPERABLEN KOLLUMKARZINOME. 

[OUR EXPERIENCE WITH CHOLINE CITRATE AS A 

TREATMENT OF INOPERABLE CERVICAL CARCINOMA.] 

Zbl. Gyn., 1952, 74: 1017-1023. 17 refs. 

Choline calcium cITrate was administered in 

the form of tablets, in daily doses of 1.75 g. 

695 

Choline treatment was used in conjunction 

with X-ray therapy on 20 patients with cervical 

carcinoma. Of 20 patients 10 died; in 

5 tumors regressed, and prognosis was diffi 

cult in 5. No bleeding was observed when 

choline-citrate was given. 

Martin, H. and Kaufmann, A. KOMBINIERTE CHUMO 

UND STRAHLENTHERAPIE BEI METASTASIERENDEN 

SEMINOMEN. [COMBINED CHEMO- AND RADIOTHERAPY 

IN SEMINOMAS WITH METASTASES.] Strahlenthera 

pie, 1953, 92: 402-411. 42 refs. English 

summary. TKree cases of metastasizing semi-- 

noma were treated with radiotherapy combined 

-with chemotherapy, which was based on the use 

of esters and of salts of choline as well as 

on sulfonamides. 

CHOLINE, 

ACETYL- 

696 

Eser. S. and Eser, G. Ã€PROPOS DE L'ACTION 

THERAPEUTIQUE DE L>ACETYLCHOLINE SUR LES 

SARCOMES PRODUITS PAR LE MÃ‰THYLCHOLANTRENE. 

[THE THERAPEUTIC EFFECT OF ACETYLCHOLINE 

ON METHYLCHOLANTHRENE-INDUCED SARCOMAS.] 

Ann. endocr., Par., 1954, 15: 234-240. 

61 refs. Abstracted in: Excerpta med., 

Sect. 16, 1955, 3: No. 1770. "Injections 

of 300/jLg. acetylcholine daily increased 

the percentage of complete regressions of 

a transplanted fibrosarcoma in rats. In 

treated rats 10 of the 15 tumours dis 

appeared as against 1 of the 9 in the 

controls. It is thought that the action 

of acetylcholine is effective by way of 

a stimulation of the adrenal cortex." 


CHROMIC 

ACID 

697 Lewenfisz, H. BRODAWCZAKI KRTANI. Ã•PAPILLOMA 

OF THE LARYNX.] Otolar. polska, 1953, 7: 

No. 4, 291-292. Papillomas of the larynx in 

23 patients were treated by cauterization 

with chromic acid. All patients improved. 

CHYMOTRYPSIN 

698 Beard, H. H. THE EFFECT OF ADMINISTRATION OF 

CRYSTALLINE CHYMOTRYPSIN UPONPLACENTAL TRANS 

PLANTS, SPONTANEOUS TUMORS AND JENSEN SARCOMA 

IN RATS. Exp. M. & S., Basel, 1949, 7: 177- 

186 8 refs. "When placental tissue from 

the pregnant rat, guinea-pig or woman is trans 

planted into the rat, it is usually digested, 

probably by the chymotrypsin of the animal's 

pancreas. One spontaneous carcinoma in a 

rat was partially digested with chymotrypsin 

but the animal died before the hydrolytic 

products of the tumour could be eliminated... 

Small Jensen sarcomas were completely digest 

ed by chymotrypsin and the tumour area healed 

rapidly thereafter. The same was true of a 

larger Jensen sarcoma, provided infection of 

the large crater was prevented. In other 

tumours of similar sizes from 60 to 80% of 

the tumour was digested, but all the animals 

died from infected craters. In extra large 

Jensen sarcomas liquefaction to about 60% 

occurred, but death was inevitable since the 

animal was unable to eliminate the hydrolytic 

products of the tumour fast enough." 

699 Krebs E. T., Krebs, E. T. J. and Gurchot, C. 

SKELETAL CHANGES ASSOCIATED WITH THE USE OF 

CRYSTALLINE CHYMOTRYPSIN IN AN APPARENTLY 

RADIO-RESISTANT GROWTH. Med. Ree., 1947, 

160: 479-480.



43 

CHYMOTRYPSIN (Continued) 

700 

Shimkin, M. B. and Bierman, H. R. CHYMOTRYPSIN 

IN CANCER. Proc. Soc. Exp. Biol., N. Y., 

1949, 71: 250-252. 4 rets. Abstracted in: 

Excerpta" med., Sect. 5, 1950, 3: No. 1486. 

"Treatment with crystalline chyinotripsin 

did not influence the course of neoplastic 

disease in experimental animals or in 15 

selected cancer patients." 

701 

Â»West, P. M. INEFFECTIVENESS OF CHYMOTRYPSIN 

THERAPY IN MALIGNANCY. 

Biol., N. Y., 1949, Til 

Proc. Soc. 

252-253. 

Exp. 

CILAG 61 

702 

Eichler, O. and Plewa, W. EINE NEUE SUBSTANZ 

MIT CARCINOLYTISCHER WIRKUNG. [A NEW COMPOUND 

WITH CARCINOLYTIC ACTION.] Arzneimitt. 

Forsch., 1952, 2: 359-361. 3 refs. 

703 

Eichler, 0. and Staib, I. DIE CARCINOCOLY- 

TISCHE WIRKUNG VON HEXAMETHYLOLMELAMIN. 

[CARCINOCOLYTIC EFFECT OF HEXAMETHYLOLMEL- 

AMINE]. 

360. 14 

Arzneimitt. Forsch., 

refs. Abstracted in: 

1953, 3: 355- 

Chem.~Abstr. 

1953, 47: NO. 10132d. 

704 

Eichler, 0. and Staib, I. DIE CARCINOCOLYTISCHE 

WIRKUNG VON HEXAMETHYLOLMELAMIN. III. VERSUCHE 

AM WALKER-CARCINOM. [CARCINOLYTIC EFFECT OF 

HEXAMETHYLOLMELAMINE. III. STUDIES ON WALKER 

CARCINOMA.] Arzneimitt. Forsch., 1954, 4: 

268-270. 6 refs. 

705 

Fiedler, H. H. and Schmalz, D. BEITRAG ZUR 

CHEMOTHERAPIE 

[CONTRIBUTION 

DER LYMPHOGRANULOMATOSE. 

ON CHEMOTHERAPY OF LYMPHO- 

GRANULOMATOSIS.] Deut. 

106-107. 12 refs. 

med. J., 1955, 6: 

706 

Fiedler, H. H. and Schmalz. D. ERFAHRUNGEN 

UND ERGEBNISSE BEI DER BEHANDLUNG 

OPERABLEN BRONCHIALKARZINOMEN MIT 

VON IN 

POLY- 

METHYLOL-MELAMINEN (CILAG 61). [EXPERIENCE 

IN AND RESULTS OF THE TREATMENT OF INOPER 

ABLE BRONCHIAL CARCINOMA WITH POLYMETHYLOL- 

MELAMINES (CILAG 61).] Medizinische, 

No. 39, 1309-1315. 9 refs. 

1954, 

707 

Leikam, H. KLINISCHE BEOBACHTUNGEN MIT DEM 

CYTOSTATICUM CILAG 61 BEI DER BEHANDLUNG 

INOPERABLER TUMOREN. [CLINICAL OBSERVATIONS 

WITH THE CYTOSTATIC AGENT CILAG 61 IN THE 

TREATMENT OF INOPERABLE TUMORS.] 35 1. 

MÃ¼nchen, 1954, (Inaug.-Diss., MÃ¼nchen). 

13 refs. 

CITRACONIMIDE 

See 

1812 3285 

CITRAL â€”¿ EFFECT 


708 

Osato, S., Ramino, J. and Iwabuchi, s. ON THE 

INHIBITING EFFECT OF CITRAL AND SOME OTHER 

ALDEHYDES ON YOSHIDA RAT SARCOMA. Gann, Tokyo, 

1949, 40: 150-152. In Japanese. 

709 

Osato, S., Kanno, J., Iwabuchi, S., Toshida, K., 

Takahashi, S. and Kawamura, E. ON THE INHI 

BITING EFFECT OF CITRAL AND SOME OTHER ALDE 

HYDES ON YOSHIDA RAT SARCOMA. Gann, Tokyo, 

1950, 4U 161-165. In Japanese. 

710 

Osato, S., Oda, K. and Hanno, A. EXPERIMENTAL 

CHEMOTHERAPY OF CANCER IN RAT WITH CITRAL- 

COMBINATIONS. In English. Gann, Tokyo, 1953, 

44: 348-349. Daily sublethal doses of citralse~micarbazone, 

citral-thiosemicarbazone and 

P, citraloxim and natrium bisulfite of citral 

were administered orally to rats with ascites 

hepatomas. No therapeutic effects were ob 

tained. 

711 

Osato, S., Oda, K. and Sato, F. ACTION DIRECTE 

DU CITRAL ET DU CITRONELLAL SUR LA CELLULE 

CANCÃ‰REUSE. [DIRECT ACTION 0F CITRAL AND 

CITRONELLAL ON CANCER CELLS.] C. rend. Soc. 

biÂ»l., 1954, 148: 768-769. 3 refs. Low 

concentrations of either citral or citronellal 

caused degeneration in cells of Yoshida 

sarcoma and Ehrlich carcinoma. 

712 

Osato, S., Oda, K. and Sato, F. CYTOLOGICAL 

STUDY 

Gann, 

ON THE 

Tokyo, 

CHEMOTHERAPY OF CARCINOMA. 

1954, 45: 561-563. In Japanese. 

THERAPY 

713 

Osato, S., Oda, K. and Kitamura, S. EFFECT OF 

CHEMOTHERAPY IN HUMAN CARCINOMA; POST MORTEM 

EXAMINATION IN CASES RECEIVING OUR CHEMO- 

THERAPEUTIC PROCEDURE. Gann, Tokyo, 1954, 

45j 499-502. In Japanese. 

714 

Osato, S., Oda, K. and Kitamura, S. SUR L'ACTION 

CARCINOCURATIVE DU CITRONELLAL ET DU CITRAL; 

UNE EXPERIENCE CLINIQUE SUR LA CHIMIOTHERAPEU- 

TIQUE DU CANCER VISCERAL. [CANCEROLYTIC EFFECT 

OF CITRONELLAL AND CITRAL; CLINICAL RESULTS OF 

THE CHEMOTHERAPY OF VISCERAL CANCER.] Bull. 

Ass. fr. cancer, 1954, 41.: 466-481. 14 refs. 

CITRONELLAL â€”¿ EFFECT ON TUMOR GROWTH 

715 Osato, S. and Kanno, J. ON THE CHEMOTHERAPY 

OF CARCINOMA II. PHARMACOLOGICAL STUDIES 

OF CITRONELLAL AND SOME OTHER ALDEHYDES. 

PRELIMINARY REPORT ON EXPERIMENTAL CHEMO 

THERAPY OF MALIGNANT TUMOR OF ANIMALS. 

Gann, Tokyo, 1948, 39: 161-163. In Japanese. 

English summary. 

See 

708 712 

THERAPY 

716 

Osato, S. ON THE CHEMOTHERAPY OF CARCINOMA 

I. PRELIMINARY REPORT. IS CHEMOTHERAPY OF 

HUMAN CANCER POSSIBLE? Gann, Tokyo, 1948 

3Â£: 159-161. In Japanese. English summary. 

717 

Â»Osato, S. ON THE CHEMOTHERAPY OF CARCINOMA. 

PRELIMINARY REPORT. IS CHEMOTHERAPY OF HU 

MAN CANCER POSSIBLE? Tohoku J. Exp. M., 

1948, 49: 206. Abstracted in: Excerpta 

med., Sect. 2, 1950, 3i No. 493. 

See 

2564 713 714 

COBALT 

718 

Castle, H. B. HEMATOLOGY. In: Clinical pro 

blems in cancer research (Sloan-Kettering 

Institute Seminar, 1948-1949) 1952, 98-105. 

719 

Heath, J. C. THE EFFECT OF COBALT ON MITOSIS 

I* Â«SSUE CULTURE. 

o â€¢¿ .illâ€”¿320, 

Exp. Cell. Res., 1954, 

720 

Kajlwara, K. THE EFFECT OF COBALTIC COMPLEX 

SALTS 

1950, 

UPON THE YOSHIDA SARCOMA. 

Â«: 168-170. In English. 

Gann, Tokyo



44 

COBALT (Continued) 

721 

Kajiwara, K. ON THE EFFECT OF COBALTIC COMPLEX 

SALTS 

1951, 


42: 272-273. In English. 

Gann, Tokyo, 

722 

Haley, L. E. and Mellor, D. P. STABILITY OF 

SOME METAL COMPLEXES OF HISTIDINE. Nature, 

Lond., 1950, 165: 453. Abstracted in: Chem. 

Abstr., 1950,TÃŽ: 5256d. 

723 

Morgan, J. F. and Parker, R. C. INTERRELATION 

SHIPS BETWEEN COBALT AND AMINO ACIDS IN TIS 

SUE CULTURE. 

38: 267-274. 

Arch. Biochem., N. Y., 1952, 

16 refs. Abstracted in: Ex 

cerpta med., Sect. 2, 1953, 6: No. 5829. 

COD LIVER OIL 

See 

2993 

COLCEM1D 

724 

Midana, A. and Ormea, F. TENTATIVI DI TRATTA 

MENTO DELLA MYCOSIS FUNGOIDES CON UN PRE 

PARATO COLCHICINICO (PREPARATO 12 669 A) 

PER VIA PARENTERALE. [THE EXPERIMENTAL TREAT 

MENT OF MYCOSIS FUNGOIDES WITH A COLCHICIN 

PREPARATION (PREPARATION 12 669 A) BY INTRA 

MUSCULAR INJECTIONS.] Minerva derm., Tor., 



725 

Rabito, C. and Leoni, A. INSUCCESSO DEL TRAT 

TAMENTO PER VIA PARENTERALE CON PREPARATO 

12 669 A(COLCEMID)IN UN CASO DI MICOSI FUNGOIDE. 

[FAILURE OF PREPARATION 12,669 A (COLCEMID) IN 

PARENTERAL THERAPY OF A CASE OF MYCOSIS 

FUNGOIDES.] Minerva derm., Tor., 1955, 30: 187- 

189. 

COLCHICAMDE 

See 

784 

COLCmCAMIDE, N-METHYL â€”¿ EFFECT 

GROWTH 

See 

901 

ON NORMAL 

EFFECT ON NORMAL GROWTH, EN 

HANCEMENT OF 

726 

LettrÃ©, H., LettrÃ©, R. and Pflanz, C. ÃœBERSY 

NERGISTEN VON MITOSEGIFTEN. VII. WEITERE 

ALKALOIDE UND COLCHICIN ODER N-METHYL-COL- 

CHICAMID. [SYNERGISTS OF MITOTIC POISONS. 

VII. FURTHER ALKALOIDS AND COLCHICINE OR 

N-METHYL-COLCHICAMID.] Hoppe Seyler Zschr., 

1951, 287: 150-157. 

731 EFFECT 733 ON734 

TUMOR GROWTH 

727 

Gropp, H. EINIGE CYTOLOGISCHE BEOBACHTUNGEN 

AN TUMORZELLEN UNTER DER WIRKUNG VON MITO 

SEGIFTEN. [CYTOLOGICAL STUDIES OF TUMOR 

CELLS UNDER THE INFLUENCE OF MITOTIC POI 

SONS.] Zschr. Krebsforsch., 1954, 60: 

9-15. 15 refs. The action of 4-azaBenzpyrene 

and N-methyl-colchicamide on mice 

ascites tumor cells are studied, singly 

See 

748 

and in combination. The fission inhibi 

ting action of N-methyl-colchicamide is 

enhanced by 15% by the addition of 1.5 mg 

of azabenzpyrene. 

COLCfflCEINAMIDES â€”¿ EFFECT ON TUMOR 

GROWTH 

728 

Leiter, J., Hartwell, J. L., Kline, I., Nadkarni, 

M. V. and Shear, M. J. DAMAGE INDUCED IN 

SARCOMA 37 WITH CHEMICAL AGENTS. IV. DERI 

VATIVES OF COLCHICEINAMIDE. 

Inst., 1952, K5: 731-739. 

J. Nat. Cancer 



729 

LettrÃ©, H. ZUR WIRKUNG VON COLCHICEINAMIDEN 

AN ZELLEN IN VITRO UND IN VIVO. [THE EFFECT 

OF COLCHICEINAMIDES ON CELLS IN VITRO AND 

IN 

11 

VIVO.] 

refs. Abstracted 

Experientia, 

in: 

Basel, 

Chem. Abstr 

1954, 

.7~T.954, 

10: 271. 

48: 10921a. 

Is~ 3-4 times 

"Colchiceine-N-mono-methylamide 

as active as colchicine as shown 

by its effect on the mouse-ascites-tumor 

(Ehrlich) and on fibroblasts in vitro." 

COLCHICEINE 

730 

Gohar, M. A. and Makkawi, M. ANTIBACTERIAL 

ACTION OF COLCHICINE ANDCOLCHICEINE. J. 

Pharm., Lond., 1951, 3: 415-419. 7 refs. 

COLCHICINE â€”¿ EFFECT, ENHANCEMENT OF 

731 

LettrÃ©, H. SYNERGISTS AND ANTAGONISTS OF MITO 

TIC POISONS. Ann. N. York Acad. Sc., 1954, 

58: 1264-1275. 42 refs. 

732 

LettrÃ©, H. ÃœBER SYNERGISTEN DES COLCHICINS. 

[SYNERGISTS OF COLCHICINE.] Arzneimitt. 

Forsch., 1951, :L:3-5. 26 refs. 

733 

LettrÃ©, H., LettrÃ©, R. and Pflanz, C. ÃœBER SY 

NERGISTEN VON MITOSEGIFTEN. II. BULBOCAPNIN, 

COLCHICIN, N-METHYL-COLCHICAMID UND IHRE KOM 

BINATIONEN. [SYNERGISTS OF MITOTIC POISONS. 

II. BULBOCAPNINE, COLCHICINE, N-METHYL-COL 

CHICAMIDE AND THEIR COMBINATIONS,] Hoppe 

Seyler Zschr., 1950, 286: 138-144. 10 refs. 

Abstracted in: Chem. Ã„b"strâ€ž, 1951, 45: 4354a. 

Combination of bulbocapnine with 

or N-methylcolchicamide enhanced 

colchicine 

the inhibi 

tion of mitosis of periosteal fibroblasts in 

vitro. 

734 LettrÃ©, H., LettrÃ©, R. and Pflanz. C. ÃœBER SY 

NERGISTEN 

COLCHICIN 

VON 

UND 

MITOSEGIFTEN. III. 

N-METHYL COLCHICAMID. 

PHLORRHIZIN, 

[SYNER 

GISTS OF MITOTIC POISON. III. PHLORRHIZIN, 

COLCHICINE AND N-METHYLCOLCHICAMIDE.l Hoppe 

Seyler Zschr., 1951, 286:â€¢212-215. 7 refs. 

Phlorrhizin is an inhibitor of the phosphatase-enzyme 

group and does not inhibit mito 

sis, therefore specific action of mitotic 

poisons cannot be attributed to phosphatase 

inhibition. Fibroblasts treated in vitro 

with phlorrhizin become more sensitive to 

colchicine and to methylcolchicamide. It is 

suggested that these compounds exert their 

action by influencing the phosphorylation 

processes of cells. 

735 

LettrÃ©, H. OBER SYNERGISTEN VON MITOSEGIFTEN. 

V. VERSUCHE ZUR AUFHEBUNG DER SYNERGISTISCHEN 

WIRKUNG DURCH PHOSPHAGEN. [SYNERGISTS OF MI 

TOTIC POISONS. V. ATTEMPTS TO NEUTRALIZE 

THE SYNERGETIC ACTION BY PHOSPHAGEN]. 

Abstracted 

Naturwissenschaften, 

in: Chem. Abstr.7~1952, 

1951, 38: 13. 

46: 

3 refs. 

2180h.



irr,:.. 

45 

COLCHICINE â€”¿ EFFECT, ENHANCEMENT OF 

(Continued) 

736 

LettrÃ©, H., LettrÃ©, R. and Pflanz. C. ÃœBER SY 

NERGISTEN VON MITOSEGIFTEN. VI. APORPHIN- 

DERIVATE UND COLCHICIN. [SYNERGISTS OF MI- 

TOTIC POISONS. VI. APORPHINE DERIVATIVES 

AND COLCHICINE.] Hoppe Seyler Zschr., 1951, 

287: 53-59. 6 reis. Colchiclne in corabination 

with 10 aporphine derivatives Â»ere 

tested. Corydine, glaucine, laurotetanine 

and laurotetanine methyl ether enhanced the 

inhibition of mitosis of fibroblast cultures 

in vitro. 

737 Lettre", H., Lettre", R. and Pflanz, C. ÃœBER SY 

NERGISTEN VON MITOSEGIFTEN. VIII. SEXUAL 

HORMONE UND COLCHICIN. [SYNERGISTS OF MITO 

SIS POISONS. VIII. SEX HORMONES AND COLCHI 

CINE]. Naturwissenschaften, 1951, 38: 70-71. 

5 reÃs. At low concentrations of cÃTchicine 

synergistic effects were obtained with testo 

sterone, testosterone propionate and epidehydroandrosterone. 

738 

LettrÃ©, H., LandschÃ¼tz, C. and Nobel, J. ÃœBER 

SYNERGISTEN VON MITOSEGIFTEN X. NEBENNIEREN- 

RINDENHORMONE UND COLCHICIN. [SYNERGISTS OF 

MITOTIC POISONS X. ADRENAL CORTICC HORMONES 

AND COLCHICINE.] Klin. Wschr., 1951, 29: 

555. 12 reÃs. Abstracted in: Chem. Abstr., 

1952, 46: 3636Ã•. 

739 

LettrÃ©, H., LettrÃ©, R. and Pflanz, C. ÃœBER SY 

NERGISTEN VON MITOSEGIFTEN. XI. EINE UNTER 

SCHEIDUNGSMÃ–GLICHKEIT VON DESOXYCORTICOSTERON 

UND CORTISON. [SYNERGISTS OF MITOSIS POISONS. 

XI. A MEANS OF DIFFERENTIATION BETWEEN DESOXY- 

CORTICOSTERONE AND CORTISONE.] Naturwissen 

schaften, 1951, 38: 214. 10 refs. The addi 

tion of desoxycorTicosterone acetate produced 

synergetic action of mitosis inhibition in 

fibroblast cultures with colchicine at a con 

centration of 0,01 mg per cc. Synergism 

appeared with cortisone at lower concentra 

tions of colchicine. 

739a 

LettrÃ©, H., LettrÃ©, R. and Pflanz, C. VERSfÃ€R- 

KUNG DER MITOSCHEHMENDEN WIRKUNG DES COLCHI 

CI NS DURCH KATATONIEERZEUGENDE STOFFE. 

[ENHANCEMENT OF THE ANTI-MITOTIC ACTION OF 

COLCHICINE BY CATION-PRODUCING SUBSTANCES.] 

Naturwissenschaften, 1950, 37; 378. 6 refs. 

Abstracted in: Excerpta med77 Sect. 2, 1951, 

4: No. 4420. 

See 

985 3150 

EFFECT ON MALIGNANT GROWTH 

740 

Bass, A. D. Probert, C. RESPONSE OF A TRANS- 

PLANTABLE LYMPHOSARCOMA TO COLCHICINE. 


When mice were treated with colchicine, 

transplanted lymphoma 6C3HED regressed per 

manently. After regression of the first 

implant an immunity to the tumor developed. 

741 

Beletskaia, L. V. VLIIANIE KOLKHITSINA I BLIZKIKH 

K NEMU SQEDINENII NA ROST EKSPEHIMENTAI. 'NYKH 

OPUKHOLEI ZHIVOTNYKH. [THE EFFECT OF COLCHICINE 

AND CLOSELY RELATED DERIVATIVES ON THE GROWTH 

OF EXPERIMENTAL TUMORS IN ANIMALS.] Tr. Akad. 

med. nauk SSSR. Vopr. onkol., 1954, No. 7, 

150-157. 9 refs. Colchicine in doses of 0.2- 

0.1 LDso injected parenterally into 20 mice 

with adenocarcinomas and sarcomas greatly in 

hibited the growth of the tumors. At the same 

time, severe toxic effects were noticed in the 

organism. The 19 colchicine derivatives showed 

lesser karyoclastic effects than colchicine. 

742 

Bessis, M., Ely, Z. and Freixa, P. ACTION DE 

DIFFERENTS PRODUITS ANTILEUCÃ‹MIQUES 

L'Ã‰RYTHROBLASTOSE TRANSMISSIBLE DES 

SUR 

POULES. 

[EFFECT OF VARIOUS ANTILEUKEMIC COMPOUNDS ON 

THE TRANSMISSIBLE CHICKEN ERYTHROBLASTOSIS.] 

Sang, Par., 1951, 22: 446-450. 

Bloch-Frankenthal, and Back, A. EFFECT OF COL 

CHICINE ON TUMOR GROWTH AND TUMOR PYROPHOS- 

PHATASE. Proc. Soc. Exp. Biol., N. Y., 1951, 

76: 105-109. 7 refs. 'Treatment of a benzopyrene 

induced 

produced tumor 

rat sarcoma 

regression. 

with colchicine 

This regression 

was complete in some cases. No hemorrhage 

has been observed in tumors treated with col 

chicine. This tumor contains a potent enzyme 

capable of hydrolyzing sodium pyrophosphate. 

The pyrophosphatase of tumors treated with 

colchicine is therehy lowered. Colcbicine has 

no effect on tumor pyrophosphatase in vitro." 

744 

Chesney, R. W. L. SOME EXPERIENCES WITH COLCHICINE 

IN THE TREATMENT OF MAMMARY TUMOURS IN THE BITCH. 

Vet. J., Lond., 1947, 103: 387-390. Abstracted 

in: Excerpta med., Sect. 5, 1948. !â€¢No. 319 

745 Francolini. C. C. L'AZIONE DELLA COLCHICINA 

SUI TUMORI DA TRAPIANTO. [EFFECT OF COLCHI 

CINE ON TRANSPLANTED TUMORS.] Neoplasie, Tor., 

1947, 2: 309-318. 16 refs. Aqueous solution 

of colchicine in doses of 1 cc when injected 

into 49 rats with transplanted benzopyrene 

sarcoma inhibited tumor growth in 2 rats, but 

did not prolong survival time or show any 

antiblastic effect on the rest of the animals. 

746 



WITH CHEMICAL AGENTS. III. COLCHICINE DERI 

VATIVES RELATED TO TRIMETHYLCOLCHICINIC ACID 

AND TO COLCHINOL. J. Nat. Cancer Inst., 

1952, !Â£: 379-392. 31 refs. 

747 

LettrÃ©, H. and Fernholz, H. VERGLEICH VON 

COLCHICIN, 1SOCOI.CI11CÃ•N UND HOMOLOGEN AUF 

IHRE ZELLTEILUNGSHEMMENDE WIRKUNG. [COM 

PARISON OF MITOSIS-INHIBITING ACTIVITIES 

OF COLCHICINE, ISOCOLCHICINE AND HOMOLOGUES.] 

Hoppe Seyler Zschr., 1952, 289: 123-127. 


6: No. 2212. 

748 

LettrÃ©, H., Krapp, R. and Ochsenschlager, M. 

WIRKUNGENDES COLCHICINS UND N-METHYLCOL- 

CHICAMIDS AUF DIE MITOSE DER ZELLEN DES 

BSUSE-ASCITESTUMORS. [EFFECT OF COLCHI 

CINE AND N-METHYLCOLCHICAMIDEON MITOSIS 

IN MOUSEASCITES TUMORCELLS]. Zschr. 

N-methylcolchicamide~^s 

Krebsforsch., 1950, 57: 

10 

142-150. 

times more 

17 refs. 

ef 

fective than colchicine. In single admini 

strations the toxicity of the drugs are 

comparable; repeated injections of N- 

methylcolchicamide has cumulative effects 

so that it is twice as toxic as colchi 

cine. 

749 

Levine. M. and Silver, G. B. MITOTIC RESPONSE 

TO COLCHICINE IN HUMAN CANCER. Proc. Soc. 


Abstracted in: Biol. AbstrT, Bait., 1948, 

22: No. 1085. A single intramuscular injec 

tion of 2 mg of colchicine caused arrest of 

nuclear division in the metaphase stage of 

human cancer. Maximum effect was reached 

between the 16th and 24th hours. There was 

an increase in hemorrhage, leucocytosis and 

some polyploid cells in biopsies taken 48 to 

72 hours after colchicine. Late telophases 

were occasionally observed.



46 

COLCfflCINE â€”¿ EFFECT ON MALIGNANT GROWTH 

(Continued) 

750 

Ludfcrd, R. J. COLCHICINK IN THE EXPERIMENTAL 

CHEMOTHERAPY OF CANCER. 

1946, 6: 89-101. 60 refs. 

J. Nat. Cancer lost., 

751 

Ludford, R. J. FACTORS DETERMINING THE ACTION 

OF COLCHICINE ON TUMOR GROWTH. Brit. J. Cancer, 

1948, 2: 75-86. 14 refs. Abstracted in: Chem. 

Abstr., 1950, 44: 8493c; Biol. Abstr.. Bait., 

1950, 24: No. 4T05. 'Treatment of soft, highlycellular, 

rapidly growing mouse tumours with 

colchicine, in dosages Just below the lethal 

dose induces haemorrhage, which results in 

tumour regression. Typically there follows 

recurrence of growth...but occasionally com 

plete regression is obtained..." 

752 Nickeil, L. G. EFFECT OF CERTAIN PLANT HOR 

MONES AND COLCHICINE ON THE GROWTH AND RES 

PIRATION OF VIRUS TUMOR TISSUE FROM RUMEX 

ACETOSA. Am. J. Botany, 1950, 37: 829-835. 

Abstracted in: Chem. Abstr., 195T, 45: 

48671. 

753 

Paolino, W. CHEMIOTERAPIA DEI TUMORI; COLCHI- 

CINA E SUOI DERIVATI; RASSEGNA SINTETICA. 

[CHEMOTHERAPYOF TUMORS; COLCHICINE AND ITS 

DERIVATIVES; REVIEW OF LITERATURE.] Minerva 

med., Tor., 1955, 46: 35-43. 106 refs. A 

review of the literature on the action of 

colchicine and its derivatives both in ex 

perimental and clinical tumors. 

754 Sato, H. INFLUENCE OF COLCHICINE UPON THE ASCITES- 

SARCOMA OF RAT (YOSHIDA SARCOMA). Gann, Tokyo, 

1948, 39: 112-117. In Japanese. English summary. 

755 

Vadova, A. V., Postnikova, Z. A. and Chistova, 

N. M. VLllANIE KARIOKLASTICHESKOGOÃ•ADA 

KOLKHIJSINA NA ZADERZHKU ROSTA I MALIGNI- 

ZATSIIU VIRUSNYKH PAPILLON U KROLIKOV. 

[EFFECTS OF THE CARYOCLASTIC POISON COLCHI 

CINE ON GROWTH OF VIRUS PAPILLOMAS IN RAB 

BITS.-] Vopr. onkol., 1955, No. 1, 32-41. 

11 refs. 

756 

Veenendaal, H. BEHANDELING VAN PAPILLOMEN VAN 

HET MONDSLIJMVLIES BU HONDEN MET COLCHICINE. 

[TREATMENT OF PAPILLOMA OF DOGS WITH COLCHI 

CINE.] Tschr. diergeneesk., 1948, TjJ:211- 


Sect. 5, 1949, 2: No. 1408. 

See 

IS 

1389 

EFFECT 

302 

1923 

759 

2975 

764 

3533 

ON MICROORGANISMS 

922 

730 


757 

Allen, M. J. ABNORMAL DEVELOPMENT IN RANA PIPIENS 

INDUCED BY COLCHICINE TREATMENT AT LATE GASTRU- 

LATION. Ohio J. Sc., 1954, 54: 83-92. 25 refs. 

758 

Astaldi, G., Bernardelli, E. and Rondanelli, E. 

LA COLCHICINE DANS L'ETUDE DE LA PROLIFERATION 

DES CELLULES HEMOPOIETIQUES DE L'EMBRYON. 

[COLCHICINE IN THE STUDY OF EMBRYONIC HEMOPOIE- 

TIC CELL PROLIFERATION.] Rev. beige path., 1952, 

21: 406-13. 1 pi. 8 refs. Report on the ef 

fects of colchicine on mitosis of hemopoietic 

cells of chick embryos. 

759 

Astaldi, G., Mauri, C. and Allegri, A. RICERCHE 

SPERIMENTALI SUI PROCESSI RIPRODUTTIVI DEL 

MIDOLLO OSSEO NORMALE E PATOLOGICO. [EXPERI 

MENTAL RESEARCHES ON THE REPRODUCTIVE PROCESSES 

OF NORMAL AND PATHOLOGICAL BONE MARROW.] Boll. 

Soc. ital. biol. sper., 1947, 23: 40-43. 


1: Ho. 1014. 

760 

Astaldi, G., Mauri, C. and Tolentino, P. 

L'INFLUENCE DE LA COLCHICINE SUR LA MATURATION 

DES Ã‰RYTHROBLASTESET DES RETICULOCYTES. Ã‰TUDE 

SUR LA MOELLE OSSEUSE IN VITRO. [INFLUENCE 0F 

COLCHICINE UPON THE MATURATION OF ERYTHROBLASTS 

AND RETICULOCYTES. A STUDY ON BONE MARROW IN 

VITRO.] Rev. belge path., 1948, 1Â£:101-114. 

35 refs. "Besides a clear stathmocinetic 

effect on the dividing erythroblasts (basophils 

and polychromatophils),colchicine slows slightly 

the passage from the polychromatic to the orthochromatic 

stage, without interfering with the 

other stages of the maturation process." 

761 

Bergner, A. D. STUDIES ON COLCHICINE DERIVATIVES. 

III. EFFECT ON MITOTIC ACTIVITY OF MOUSE SPER- 

MATOGONIA. Cancer, N. Y., 1950, 3: 134-141. 

1 pi. 3 refs. Abstracted in: Excerpta med., 

Sect. 5, 1954, 7: No. 421. 

762 Boll, I. BEEINFLUSSUNG DER ERYTHRO- UND LEUKOPOESE 

DURCH DIE MITOSEGIFTE COLCHICIN UND XANTHOPTERIN 

IN VITRO. [IN-VITRO EFFECTS OF THE MITOTIC POI 

SONS COLCHICINE AND XANTHOPTERIN ON ERYTHROPOIESIS 

AND LEUCOPOIESIS.] Acta haeraat.,Basel., 1953, 


ned., Sect. 16, 1954, No. 558. 

763 

Boll, I. ÃœBERDIE EINWIRKUNG VON MITOSEGIFTEN 

AUF MENSCHLICHES KNOCHENMARKIN VITRO. [THE 

EFFECT OF MITOTIC POISONS ON HUMANBONE MAR 

ROW IN VITRO.] Verb. Deut. Ges. inn. Med., 

1952, 58: 

Abstr.7~1953, 

805-808. 

I: 

Abstracted 

No. 140. 

in: Leukemia 

764 

Branch, C. F., Fogg, L. C. and Ullyot, G. E. 

COLCHICINE AND COLCHICINE-LIKE COMPOUNDS AS 

CHEMOTHERAPEUTIC AGENTS. Acta UniÃ³ Internat. 

Cancr., Brux., 1949, 6: 439-447. 

765 

Brun, R., Bujard, E., Jadassohn, W., Cherbuliez, 

E., Paillard, R. and Gaudln, P. ACTION CARYO- 

CLASIQUE DE QUELQUES DERIVES DE LA COLCHICINE 

ET DE LA PODOPHYLLINE AU NIVEAU DE LA TETINE 

DU COBAYE. [KARYOKLASTIC ACTION OF SOME COL 

CHICINE AND PODOPHYLLIN DERIVATIVES ON THE 

NIPPLES OF GUINEA-PIGS.] Schweiz. Zschr. 

allg. Path., 1951, 14: 612-617. 6 refs. 


5: No. 1942. 

766 

Bucher, O. DIVISIONS NUCLÃ‰AIRESAMITOTIQUES 

DANS DES CULTURES DE FIBROCYTES APRÃˆSAD 

MINISTRATION DE COLCHICINE. [AMITOTIC 

NUCLEAR CELL DIVISION IN FIBROBLAST CUL 

TURES AFTER THE ADMINISTRATION OF COLCHI 

CINE.] Acta Anat., Basel, 1947, 4: 60- 

67. Approx. 40 refs. 

767 Bullough, W. S. THE ACTION OF COLCHICINE IN 

ARRESTING EPIDERMAL MITOSIS. J. Exp. Biol., 

Lond., 1949, 26: 287-291. 7 refs. 

768 Buvat, R. and Tuchmann, H. ACTION DE LA COL 

CHICINE ET DE QUELQUES SUBSTANCES RÃ‰PUTÃ‰ES 

TOXIQUES SUR LA CELLULE VIVANTE. [ACTION 

0F COLCHICINE AND SOME REPUTEDLY TOXIC SUB 

STANCES ON THE LIVING CELL.] C. rend. Acad. 

se., 1947, 224: 1377-1379. Approx. 5 refs. 

769 Chiti, E. LA COLCHICINA E LE SUE APPLICAZIONI 

IN BIOLOGIA. [COLCHICINE AND ITS BIOLOGICAL 

APPLICATIONS]. Arch. Maragliano pat. clin., 

1947, 2: 820-829. Approx. 85 refs.



47 

COLCHICINE â€”¿ EFFECT ON NORMAL GROWTH 

(Continued) 

770 Fleischmann, W. and Ullyot, G. E. STUDIES ON 

COLCHICINE DERIVATIVES. II. EFFECT ON III- 

TOTIC ACTIVITY OF THE CORNEAL EPITHELIUM. 

Cancer, N. Y., 1950, 3: 130-133. 9 refs. 

Colchicine and 6 derivatives were investi 

gated. Colchicine was the most toxic. The 

less toxic compounds were in general less 

effective on mitosis with the exception of 

trimethylcolchicinic acid methyl ether, 

which arrested mitosis significantly at 

1 / 100 of the LD50. 

771 

Gaulden, H. E. and Carlson, J. G. CYTOLOGICAL 

EFFECTS OF COLCHICINE ON THE GRASSHOPPER 

NEUROBLAST IN VITRO WITH SPECIAL REFERENCE TO 

THE ORIGIN OF THE SPINDLE. Exp. Cell. Res., 

1951, -i\416-433. pi. 34 refs. 

772 Grampa, G. AZIONE CITOPLASMATICA DELLA COL- 

CHICINA NEL FEGATO NORMALE E IN RIGENERAZIONE 

SPERIMENTALE. [EFFECT OF COLCHICINE ON THE 

PROTOPLASM OF CELLS OF THE NORMAL AND REGENER 

ATING LIVER.] Studia ghisler., 1949, U 261- 


Sect. 5, 1952, 5: No. 2389. 

773 

Harven, E. de and Gerard, P, SUR L'ACTIVITÃ‰ 

MITOTIOUE DES MYÃ‰LQCYTES EOSINOPHILES CHEZ 

LE RAT COLCHICINISE. [MITOTIC ACTIVITY OF 

EOSINOPHIL MYELOCYTES IN RATS AFTER COLCHI 

CINE ADMINISTRATION.] C. rend. Soc. biol., 

1953, 147: 911-913. 4 refs. 

774 Havas, L. J. SUR QUELQUES PROBLEMES DE 

CROISSANCE Ã‰TUDIES Ã€L'AIDE DE LA COLCHICINE 

CHEZ LES PLANTES ET CHEZ LES ANIMAUX. [SOME 

PROBLEMS OF GROWTH STUDIED IN PLANTS AND 

ANIMALS BY MEANS OF COLCHICINE.] Ann. Soc. 

se. mÃ©d. nat. Bruxelles, 1948, 1: 57-77. 


5, 1949, 2: No. 2885. A lecture reviewing 

the literature of "...the reactions of plants 

to Colchicine, particularly with respect to 

phytocarcinomas and hormonal action; it is 

also concerned...with the effect of colchicine 

on growth in rats, on the development 

of Rana temporaria and on the phenomenon 

of the 'bridal gown' in Rhodeus amarus." 


775 Hayas, L. J. and Kahan,,J. REACTIONS DES VERS 

A SOIE (BOMBYX MQRI) A LA COLCHICINE, LA 

PODOPHYLLINE ET A L'ACENAPHTENE. [THE RE 

ACTION OF'SILK WORMS (BOMBYX MORI) TO 

COLCHICINE, PODOPHYLLIN AND ACENAPHTHENE.] 

Arch. biol. hung., 1948, 18: 117-131. 

55 refs. Depending on the doses used, 

Colchicine and podophyllin either inhibit 

or stimulate the hatching of silk worms. 

Acenaphthene always inhibits hatching. 

Colchicine increases the length and weight 

of the silk worm body. 

776 Isler, H. QUELQUES EXPERIENCES DE LABORATOIRE 

SUR LA COLCHICINE ET LA PODOPHYLLINE. [LA 

BORATORY EXPERIMENTS WITH COLCHICINE AND 

PODOPHYLLIN.] Schweiz, med. Wschr., 1950, 

80: 438. 

777 

Jenkins, W. R. and Bohren, B. B. THE EFFECT 

OF COLCHICINE ON THE SEMINIFEROUS TUBULES OF 

FOWL TESTIS. Poultry Sc., 1949, 28: 650-652. 

Abstracted in: Chem. Abstr., 19507-44: 1606d. 

779 

Lehmann, F. E. and Hadorn, H. VERGLEICHENDE 

WIRKUNGSANALYSE VON ZWEI ANTIMITOTISCHEN 

STOFFEN, COLCHICIN UND BENZOCHINON, AM TUBIFEX- 

EI. [COMPARATIVE ANALYSIS OF THE ACTION OF 

TWO ANTIMITOTIC AGENTS, COLCHICINE AND BENZO- 

QUINONE, ON THE EGG OF TUBIFEX]. Helvet. 

physiol. pharm. acta, 1946, 4: 11-42. 34 refs. 

780Lettre, H. and Albrecht, M. 'ÃœBERDIE ABHÃ„NGIG 

KEIT DER COLCH1CINWIRKUNG VON DER ADENOSINTRI- 

PHOSPHORSÃ„URE. [DEPENDENCE OF COLCHICINE ACTION 

ON ATP.] Naturwissenschaften, 1951, 38: 547- 

548. 8 refs. Colchicine at a concentration of 

0.04 /Â«.gper ml produced mitosis inhibition of 

fibroblast cultures after 1 hr. This effect 

was not observed until 4 hours later, when 

ATP in concentration of 1 mg per ml was added 

to the former agent. The experiment demonstra 

ted that the inhibitory action of Colchicine 

is antagonized by ATP present in the cell. 

781 

Levine, M. THE ACTION OF COLCHICINE ON CELL 

DIVISION IN HUMAN CANCER, ANIMAL, AND PLANT 

TISSUES. Ann. N. York Acad. Sc., 1951, 51: 

1365-1408. Discussion: p. 1406-1408. 78 refs. 

Abstracted in: Chem. Abstr., 1951, 45: 5803h. 

A review of the literature and a report of 

the author's own work dealing with: (1) ef 

fect of colchicine on root-tips of Allium 

cepa: (2) action of colchicine on advanced 

neoplasms in man; and (3) colchicized plant 

tissues as influenced by x-rays. 

782 

LÃ¼scher, M. HEMMT ODER FORDERT COLCHICIN DIE 

ZELLTEILUNG IM REGENERIEREDEN SCHWANZ DER 

XENOPUS-LARVE? [DOES COLCHICINE INHIBIT OR 

PROMOTE CELL DIVISION IN THE REGENERATING 

TAIL OF THE XENOPUS LARVA?] Rev. Suisse 

Zool., 1946, 53: 481-486. 7 refs. 

783 

LUscher, M. DIE HEMMUNG DER REGENERATION DURCH 

COLCHICIN BEIM SCHWANZ DER XENOPUS-LARVE UND 

IHRE ENTWICKLUNGSPHYSIOLOGISCHE WIRKUNGSANALYSE. 

[THE INHIBITION OF THE REGENERATION OF THE 

TAIL OF THE XENOPUS-LARVA BY COLCHICINE AND 

AN ANALYSIS OF ITS MODE OF ACTION IN THE LIGHT 

OF DEVELOPMENTAL PHYSIOLOGY,] Helvet. physiol. 

pharm. acta, 1946, 4: 465-494. 21 refs. 

784 Malinsky, J. and Lang, B. EFFETS DE LA COLCHI 

CINE, DE L'ISOCOLCHICINE ET DE L'AMIDE DE 

COLCHICINE SUR LA MITOSE. [EFFECTS OF COLCHI 

CINE, ISOCOLCHICINE AND COLCHICAMIDE ON MI 

TOSIS.] C. rend. Soc. biol., 1951, 145: 

613-616. 5 refs. 

785 Malinsky, J. and Lang, B. HYPERPLASIE DU FOIE 

DE RAT APRES HEPATECTOMIE PARTIELLE ET IN 

FLUENCE DES CORPS COLCHICINÃ‰S SUR CELLE-CI. 

[HYPERPLASIA OF THE RAT LIVER AFTER PARTIAL 

HEPATECTOMY AND THE INFLUENCE 0F COLCHICINE 

THEREON.] C. rend. Soc. biol., 1951, 145: 

609-612. 

MatkÃ³ L. and Haraszti, A. THE EFFECT OF CHRONIC 

CHOLCHICINE INTOXICATION ON THE BLOOD COUNT AND 

ON THE BONE MARROW. Acta morph. hung., 1952, 

2: 219-230. 2 pi. 9 refs. "...gradually 

progressing secondary aplastic bone marrow is 

brought about which finally leads to the com 

plete termination of myelopoesis, as well as 

to the fibrous transformation of the bone 

marrow." 

778 

Kantner, H. DER EINFLUSS DES COLCHICINS AUF DIE 

ZELLTEILUNG LEBENDER AMPHIBIEN. [INFLUENCE OF 

COLCHICINE ON THE CELL DIVISION OF LIVING 

AMPHIBIA]. Zschr. Anat. Entw., 1950, 115: 

273-286. 15 refs. Abstracted in: Chem. Abstr. 

1951, 45: 5328b. 

787 Meier, R. MODIFICACIONES ESPECIFICAS DEL CRE 

CIMIENTO CELULAR. [SPECIFIC CHANGES IN CELL 

GROWTH.] An. med. dr., Barcel., 1948, 23: 

221-233. Abstracted in: Excerpta med., SEct. 

2, 1949, 2: No. 2170. A lecture.



48 

COLCHICINE â€”¿ EFFECT 

(Continued) 


788 

Musotto, G. and Dlquattro, C. SULL1IPERPLASIA 

DELLE CELLULE ISTIOCITARIE IN SEGUITO A DOSI 

RIPETUTE DI COLCHICINA. [ON THE HYPERPLASIA 

OF HISTIOCYTES FOLLOWING REPEATED DOSES OF 

COLCHICINE.] Pathologica, Genova, 1947, 39: 

204-208. 2 reÃs. English summary. Abstracted 

In: Chem. Abstr., 1948, 42: 3481d. 

789 

Pansini, R. CONTRIBUTI SPERIMENTALI SUI VELENI 

ANTIMITOSICI; INFLUENZA DELLA COLCHICINA SULLA 

MORFOGENESI DELLE UOVA DI PARACENTRCTUS LIVIDUS. 

[ANTIMITOTIC POISONS; EFFECT OF COLCHICINE ON 

MORPHOGENESIS OF EGGS OF PARACENTRCTUS LIVIDUS.] 

Arch. pat. clin., 1950, 28: 193-215. 

790 Perri, G, CONSIDERAZIONI SULL'OVAIO DI CAVIA 

COBAJA TRATTATI CON OOLCHICINA; NOTA I-III. 

[STUDY OF THE OVARY IN GUINEA PIGS TREATED 

WITH COLCHICINE.] Boll. Soc. ital. biol. 

sper., 1946, 22: 502-506. 1 rÃ©f. 

791 

Peters, J. J. CYTOLOGICAL STUDY OF MITOSIS IN 

THE CORNEA OF TRITURUS VIRIDESCENS DURING 

RECOVERY AFTER COLCHICINE TREATMENT. J. Exp. 

Zool., 1946, 103: 33-59. 2 pi. 38 reÃs. 

792 

Prada, N. AZIONE DI SOSTANZE CARIOCLASICHE 

SOPRA LA RIGENERAZIONE IN ANFIBI. [EFFECT OF 

KARYOCLASTIC SUBSTANCES ON AMPHIBIOUS RE 

GENERATION.] Tumori, Milano, 1950, 24: 66- 

74. 11 reÃs. â€”¿ 

793 

Samartino, G. T. and Rugh, R. EFFECTS OF COL 

CHICINE ON THE FROG IN RELATION TO OVULATION 

AND EARLY DEVELOPMENT. Proc. Soc. Exp. 

N. Y., 1946, 63: 424-427. 27 reÃs. 

Biol., 

794 

Santavy, F., Lang, B. and Malinsky, J. L'ACTION 

MITOTIQUE ET LA TOXICITÃ‰DES NOUVELLES SUB 

STANCES ISOLEES DU COLCHIQUE (COLCHICUM AUTUN 

NALE L.). SUBSTANCES TIRÃ‰ESDU COLCHIQUE ET 

LEURS DÃ‰RIVÃ‰S.[THE MITOTIC ACTION AND TOXI- 

CITY OF NEW SUBSTANCES ISOLATED FROM COLCHI 

CUM (COLCHICUM AUTOMNALE L. ) . SUBSTANCES EX 

TRACTED FROM COLCHICUM AND THEIR DERIVATIVES.] 

Arch, internat, pharm. dyn., Par., 1950, 84; 

257-268. 25 reÃs. Abstracted in: Chen. XTistr. 

1951, 45: 43421. 

795 

Schjeide, O. A., Allen, B. M. and Piccirillo, 

R. T. CYTOLOGICAL EFFECTS OF X-IRRADIATION 

AND COLCHICINE APPLIED SEPARATELY AND IN 

COMBINATION. J. Cellul. Physiol., 1952, 


med., Sect. 2, 1954, 7: No. 722. 

796 Sentein, P. L'ACTION DE LA COLCHICINE, DE LA 

PODOPHYLLINE ET DE L'HYDRATE DE CHLORAL SUR 

LES MITOSES SPERMATOGENETIQUES CHEZ QUELQUES 

URODELES. [THE ACTION OF COLCHICINE, PODO- 

PHYLLIN AND CHLORAL HYDRATE ON THE SPERMATO- 

GENETIC MITOSIS IN SOME URODELES.] Arch. 

anat. micr., Par., 1954, 43: 79-116. 36 refs. 

"The action of antimitotic~~substances as 

colchicine, podophyllin and chloral, both 

after immersion and injection, on spermatogenesis 

in Urodeles especially Triturus 

alpestris and helveticus, has been studied. 

Colchicine and podophyllin have a strong 

antimitotic action. At certain concentrations, 

colchicine 1/1000-1/2500, podophyllin 1/4 and 

1/8 saturated, they completely block the 

divisions of spermatogonia 1 and 2 and spermatocytes. 

..The agglutination of chromosomes 

leads to pyknotic degeneration, which occurs 

regularly in gonia 2... The antimitotics have 

no effect on the centrosome outside the 

mitosis." 

797 Sentein,,P. L'ACTION DE LA COLCHICINE SUR LA 

PROLIFERATION CELLULAIRE D'APRES QUELQUES 

TRAVAUX RECENTS. Ã•THEACTION 0F COLCHICINE 

ON CELLULAR PROLIFERATION BASED ON SOME 

RECENT WORKS.] Sera, hop., Par., 1948, 24: 

21-24. 37 refs. Abstracted in: Excerpta" 

med., Sect. 2, 1948, 1: No. 4553. 

798 Sentein, P. VARIATIONS DE L'ACTION EXERCÃ‰E 

PAR LA COLCHICINE ET LE CHLORAL PENDANT LE 

DÃ‰VELOPPEMENTLARVAIRE DE DISCOGLOSSUS 

PICTUS OTTH. [VARIATIONS OF THE EFFECT OF 

COLCHICINE AND CHLORAL ON THE DEVELOPMENT 

OF THE LARVA OF DISCOGLOSSUS PICTUS OTTH.] 

C. rend. Soc. biol., 1947, 141: 355-356. 

5 refs. 

799 Shirasaki, K. TISSUE CULTURES WITH THE ADDI 

TIONS 0F COLCHICINE AND PODOPHYLLIN. Igaku 

6 seibutugaku, 1950, 16: 267-269. 3 refs. 

In Japanese. 

800 Teir, H. COLCHICINE TESTS FOR THE PURPOSE OF 

ASCERTAINING CELL-DIVISION REGENERATIVE CON 

DITIONS 

microb. 

IN THE LIVER OF THE RAT. 

scand., 1948, 25: 45-51. 

Acta path, 

Discussion: 

p. 51-53. 8 refs. Abstracted in: Chem. 

Abstr., 1948, 42: 6462c. 

801 Venable, J. H. THE EFFECT OF COLCHICINE ON THE 

RAT EMBRYO. Anat. Ree., 1946, 9Â¿: 528-529. 

See 

325 664 

1088a 1724 

2975a 3180 

665 

1947 

666 

2233 

667 

2764 

EFFECT ON NORMAL GROWTH, COUNTERACTION 

TO 

802 Benitez, H. H., Murray, M. R. and Chargaff, E. 

ANTAGONISM BETWEEN TROPOLONE AND COLCHICINE 

IN RAT 

Basel, 

FIBROBLAST CULTURES. Experientia, 

1953, Â£: 426-427. 3 refs. Abstracted 

in: Chem. Abstr., 1954, 48: 5356d. "Tropo- 

Ione, the simplest structural analog of col 

chicine, is antagonistic to the metaphasearresting 

action of colchicine." - Chem. 

Abstr. 

803 

Benitez, H. H., Murray, M. R. and Chargaff, E. 

STUDIES ON INHIBITION OF THE COLCHICINE EF 

FECT ON MITOSIS. Ann. N. York 

1954, 58J 1288-1302. 26 refs. 

Acad. Sc., 

804 

Bucher, O. WEITERE UNTERSUCHUNGEN ÃœBERDIE 

WIRKUNG 4. DER EINFLUSS VON COLCHICIN VON ASCORBINS'Ã‚URE AUF GEWEBEICULTUREN. (VITAMIN 

C), ARABOASCORBINSÃ„UREUND p-CHINON AUF DIE 

COLCHICINWIRKUNG. [FURTHER OBSERVATIONS ON 

THE ACTION OF COLCHICINE ON TISSUE CULTURES. 

4. 

C), 

THE INFLUENCE OF ASCORBIC ACID (VITAMIN 

AHABOASCORBIC ACID, AND'P-QUINONE ON THE 

ACTION 

Bakt., 

OF COLCHICINE.] 

1946, 9: 643-657. 

Schweiz, 

18 refs. 

fedir. Path. 

English 

summary. 

805 

Costa, E.. Napoleone. 

TORNO AL MECCANISMO 

C. and Pani, 

DELL'EFFETTO 

M. L. IN 

LEUCOCITOSICO 

DELLA COLCHICINA. 

CYTOSIS-PRODUCING 

[MECHANISM OF THE LEUCO- 

EFFECT OF COLCHICINE.] 

Arch. sc. biol., Bologna, 1952, 36: 553-557. 

8 refs. 

806 

Murray. M. 

SPECIFIC 

R.. Lam. H. H. de and Chargaff. E. 

INHIBITION BY MESO-INOSITOL OF THE 

COLCHICINE EFFECT ON RAT FIBROBLASTS. Exp. 

Cell. Res., 1951, 2: 165-177. 13 refs. 

See 

735 

1. Colchicine-Effect on spermatpgenic mitosis. 

2. Podophyllin-Effect on spermatpgenic mitosis.



49 

COLCHICINE â€”¿METABOLISM (INCLUDING EFFECTS 


807 

Back, A. and Walaszek, E. J. FIXATION OF RADIO 

ACTIVE COLCHICINE BY EHRLICH ASCITES CARCINOMA 

CELLS. Nature, Lond., 1953, 172: 202-203. 

The quantity fixed seemed to b~ein accord with 

the amount needed to give a karyoclastic in 

fluence on cells. 

808 

Back, A. and Walaszek, E. J. STUDIES WITH 

RADIOACTIVE COLCHICINE. I. THE INFLUENCE 

OF TUMORS ON THE TISSUE DISTRIBUTION OF 

RADIOACTIVE 

Res., 1953, 

COLCHICINE IN MICE. Cancer 

13: 552-555. 17 refs. Radio 

active colchiclne accumulated in signifi 

cant amounts in the spleens of normal mice 

while none was found in spleens of tumorbearing 

mice. The intestines of tumorbearing 

mice accumulated more colchicine 

than intestines of normal mice. Lyophilized 

tumor tissue, when injected into 

normal mice had an action similar to that 

of a tumor in situ. 

809 

Back, A., Walaszek, E. and Uyeki, E. DISTRIBUTION 

OF RADIOACTIVE COLCHICINE IN SOME ORGANS OF 

NORMAL AND TUMOR-BEARING MICE. Proc. Soc. Exp. 

Biol., N. Y., 1951, 77: 667-669. 5 refs. 


5: No. 4007; Chem. Abstr., 1951, 45: No. 10357ÃŒ. 

810 

Bass, A. D.and Place, E. F. URIC ACID AND 

ALLANTOIN EXCRETION IN NORMAL AND TUMOR- 

BEARING MICE. J. Biol. Chem., 1949, 181: 

81-87. 13 refs. Abstracted in: Chenu 

Abstr., 1950, 44: 2634d. 

811 

Bloch, D. P. EFFECT OF COLCHICINE ON SYNTHESIS 

OF DESOXYRIBONUCLEIC ACID IN TISSUE CULTURED 

RAT FIBROBLASTS. Proc. Soc. 

1953, 83: 341-346. 12 refs. 

Exp. Biol., 

Colchicine 

N. Y., 

does 

not directly inhibit DNA synthesis. 

812 

Ebner, H. and Strecker, H. ÃœBER DIE WIRKUNG 

DES COLCHICINS IN VIVO AUF DIE ALKALISCHE 

PHOSPHATASE DER RATTENLEBER. [EFFECT OF 

COLCHICINE IN VIVO ON THE ALKALINE PHOS 

PHATASE OF RAT LIVER]. Experientia, Basel, 



813 Ferguson, F. C., Jr. COLCHICINE. II. META 

BOLISM OF FROG SKELETAL MUSCLE. 

Exp. Ther., 1953, 108: 186-200. 

J. Pharm. 

tab. 14 

refs. 

814 

Frei, W. and Brunner, T. BEZIEHUNGEN ZWISCHEN 

ZELLTEILUNG UND OXYDATION BEI BAKTERIEN. 

SCHÃ„DIGUNG DER AEROBEN UND ANAEROBEN OXY 

DATION VON BAKTERIEN MIT CYANKALI, PYRIDIN, 

COLCHICIN UND ULTHAVIOLETTSTRAHLEN. [RELA 

TION BETWEEN CELL DIVISION AND OXIDATION 

PROCESSES IN BACTERIA. INTERFERENCE WITH 

AEROBIC AND ANAEROBIC OXIDATION IN BACTERIA 

BY CYANIDE, PYRIDINE, COLCHICINE, AND ULTRA 

VIOLET IRRADIATION.] Helv. physiol. pharm. 

acta, 

pecially: 

1947, 

p.~260. 

5j 252-264. 

Abstracted 

7 refs. 

in: Cbera. 

See es 

Abstr., 

1948, 42: 943Ã•. "The above agents inhibit 

oxidation processes in bacteria, yeasts and 

trichomonads and thereby decrease the rate 

of cell division." -Chem. Abstr. 

815 

Grixoni, F. RICERCHE ISTOCHIMICHE SUL METABO 

LISMO DEGLI ACIDI NUCLEINICI NEGLI EPITE 

LIOMI BASOCELLULARI CUTANEI TRATTATI CON 

APPLICAZIONI EPITOPICHE DI COLCHICINA. [HISTO- 

CHEMICAL RESEARCH ON THE METABOLISM OF NUCLEIC 

ACIDS IN BASAL CELL CARCINOMA OF THE SKIN 

TREATED WITH EXTERNAL APPLICATIONS OF COLCHI 

CINE.] Minerva derm., Tor., 1953, 28: 6-10. 

Abstracted in: Excerpta ned., Sect. 16, 1954, 

2: No. 4830. 

816 

Keibl, E. and Spitzy, K. H. ZUM PROBLEM DES 

LEUKOZYTENSTOFFWECHSELS. 2. EINFLUSS VON 

HONTGENSTRAHLEN, 

DEN STOFFWECHSEL 

URETHAN UND COLCHIZIN 

MYELOISCH-LEUKAMISCHER 

AUF 

ZELLEN. 

BOLISM. 

[THE PROBLEM OF LEUCOCYTES META 

2. EFFECTS OF X-RAYS, URETHANE 

AND COLCHICINE ON THE METABOLISM OF MYELOID 

LEUKEMIC CELLS.] Arch. exp. Path., Beri., 



4413. 

817 

Klein, G., Klein, E. and Klein, E. THE VIABILITY 

AND THE AVERAGE DESOXYPENTOSENUCLEIC 

TENT OF MICRONUCLEI-CONTAINING CELLS 

ACID CON 

PRODUCED 

BY COLCHICINE TREATMENT IN THE EHRLICH ASCITES 

TUMORS. Cancer Res., 1952, 1^: 484-489. 1 pi. 


46: No. 10444d. 

818 

Lang, K., Siebert, G. and Estelmann, W. HEMMUNG 

DER ADENOSINTRIPHOSPHATASE DURCH COLCHICIN. 

[INHIBITION OF ADENOSINE TRIPHOSPHATASE BY 

COLCHICINE.] Experientia, Basel, 1951, 7: 

379-380. 8 refs. 

819 

Lang, K., Siebert, G. and Oswald, H. ÃœBER DIE 

HEMMUNG VON DESOXYHIBONUCLEOTIDE SPALTENDEN 

FERMENTEN DURCH COLCHICIN. 

DESOXYNUCLEOTIDE-SPLITTING 

[INHIBITION OF 

ENZYMES BY COL 

CHICINE.] Experientia, Basel, 1949, 5: 449. 


44: 4523Ã•. 

820 

Milletti, A. STUDI SUL METABOLISMO PROTEICO 

CELLULARE; CONFRONTO TRA IL MECCANISMO DI 

AZIONE DI SOSTANZE AD AZIONE MITOCLASICA 

DIVERSA (COLCHICINA, CLORAMIN, TRIPAFLAVINA). 

[CELLULAR PROTEIN METABOLISM. INFLUENCE OF 

SUBSTANCES OF MITOCLASTIC ACTION (COLCHICINE, 

CHLORAMINE, TRYPAFLAVINE).] 

Bologna, 1951, 20: 284-288. 

Endocr. sc. cost., 


Chem. Abstr., 1352, 46: 6752ÃŒ. 

821 Â«Muletti, A. STUDI SUL METABOLISMO PROTEICO 

CELLULARE. INFLUENZA DELLA COLCHICINA SULLA 

STRUTTURA MORFOLOGICA E CITOCHIMICA DELLE 

CELLULE SIEROSE. [STUDIES ON CELLULAR META 

BOLISM OF PROTEINS. EFFECT OF COLCHICINE ON 

THE MORPHOLOGICAL AND CYTOCHEMICAL CHARACTERS 

OF SEROUS CELLS.] Bull. Sc. med., Bologna, 

1951, 123: 288-291. 

822 Schoetensack, W. BEEINFLUSSUNG VON PHOSPHATASEN 

DURCH MITOSEGIFTE. [EFFECT OF MITOTIC POISONS 

ON PHOSPHATASES.] Naturwissenschaften, 1948, 

35: 285. 5 refs. Abstracted in: Chem. Abstr., 

T9~50, 44: 3148g. 

823 Schoetensack, W. ZUR KENNTNIS DER COLCHICIN- 

WIRKUNGEN. [EFFECTS OF COLCHICINE.] Arch, 

exp. Path., Beri., 1950, 212: 117-118. 

See 

27 121 394 743 2208 

3574 MODE OF ACTION 

824 

Â»Costa, E., Pani, M. L. and Napoleone, C. INTORNO 

AL MECCANISMO DELL'EFFETTO LEUCOCITOSSICO DELLA 

COLCHICINA. [MECHANISM OF THE LEUKOCYTOSIS 

EFFECT OF COLCHICINE.] Boll. Soc. ital. biol 

sper., 1951, 27: 1647-1648. 

825 

Mugler, A. COLCHICINE ET ACTH. [COLCHICINE 

AND ACTH.] Sem. hSp. Paris, 1952, 28: 136- 

138. 16 refs.



50 

COLCHICINE â€”¿MODE OF ACTION (Continued) 

826 

Roques, H. MODES D'ACTION DE LA COLCHICI NE SUR 

LES TUMEURS A VIRUS. [ACTION 0F COLCHICINE 

ON VIRUS TUMORS.] Bull, algÃ©r. carcin., 1951, 

4: 146-150. Abstracted In: Excerpta med., 

Sect. 5, 1952, 5: No. 2702. 

827 

Wldmann, H. TIEREXPERIMENTELLE UNTERSUCHUNGEN 

ÃœBER DEN WIRKUNGSMECHANISMUS DES COLCHICINS 

IN LETALEN UND SUBLETALEN DOSEN AUF BLUT UND 

KNOCHENMARK. [EXPERIMENTAL STUDIES ON THE 

MODE OF ACTION OF LETHAL AND SUBLETHAL DOSES 

OF COLCHICINE ON BLOOD AND BONE MARROW.] 

Arch. exp. Path. Lpz., 1949, 207: 218-242. 

Approx. 40 reÃa. Abstracted In: Excerpta 

med., Sect. 2, 1951, 4: No. 1619. 

828 Wldmann, H. TIEREXPERIMENTELLE UNTERSUCHUNGEN 

ZUR Ã„TIOLOGIE DER LEUCOPENISCHEN PHASE NACH 

COLCHICINE. [EXPERIMENTAL ANIMAL STUDIES ON 

THE ETIOLOGY OF THE LEUCOPENIC PHASE FOLLOWING 

COLCHICINE ADMINISTRATION.] Fol. haemat., 

Lpz., 1952, 71; 257-266. 19 refs. 

829 

Widmann, H. and Sauter, H. D. DAS SYNDROM DER 

ALLGEMEINEN ANPASSUNG VON H. SELYE, SEINE 

BEZIEHUNGEN ZUR LEUKOPOESE UND ZU DEN LEUKO 

ZYTENBEWEGUNGEN NACH COLCHICININJEKTIONEN. 

[SELYE'S ADAPTATION SYNDROME AND ITS RELA 

TIONSHIP TO LEUCOCYTOPOIESIS AND THE LEUCO 

CYTE CHANGES FOLLOWING INJECTION OF COLCHI 

CINE.] Zschr. ges. inn. Med., 1952, 7: 170- 


Sect. 3, 1952, 6: No. 1960, "The effect of 

colchicine on th~e blood picture of rats is 

See 

discussed in detail. The intensity of leu 

cocyte changes observed in adrenalectomized 

animals was largely dependent on the general 

condition. But in general the effect was 

similar to that observed in normal animals. 

This leads to the conclusion that the effect 

of colchicine on the leucocyte blood picture 

is not based on an anterior pituitary-adrenocortical 

stress mechanism. It is contended 

that colchicine exerts a direct influence on 

the bone marrow and the leucocytes, which 

gives rise to leucocyte changes resembling 

those seen in the adaptation syndrome." 


29 122 2950 3107 

PHARMACOLOGICAL AND PHYSIOLOGICAL 

EFFECTS 

830 BarÃ¡ny, E. and Palis, A. HEMMUNG DES VIS- 

KOSITÃ„TSABFALLES IN ATP-ACTOMYOSIN-MISCHUNGEN 

DURCH COLCHICIN. [INHIBITION OF THE VISCOSITY 

DECREASE IN ATP-ACTOMYOSIN MIXTURES BY COLCHI 

CINE.] The viscosity Naturwisschenschaften, of actomyosin solutions~Tpre- 

1951, 38: 547. 

pared from heart muscle) decreases upon the 

addition of ATP. This effect can be partially 

inhibited by the addition of colchicine. 

831 

BrÃ¤m, A. ZUM VERHALTEN DER MITOCHONDRIEN BEI 

EINWIRKUNG VERSCHIEDENER PHARMAKA. UNTER 

SUCHUNGEN MIT DEM PHASENKONTRASTMIKROSKOP 

AN GEWEBEKULTUREN. [EFFECT OF VARIOUS DRUGS 

ON MITOCHONDRIA; TISSUE CULTURE STUDIES BY 

MEANS OF PHASE CONTRAST MICROSCOPY.] Acta 

anat., Basel, 1951, 1_3: 385-402. Bibliography: 

p. 401-402. English summary. Study includes 

colchicine, nicotine, arsenic, trypaflavine 

and nitrogen mustard and a review of the 

literature. 

832 if, 

Comi, G. and Arcangeli, P. L1INTRADERMOREAZIONE 

ALLA COLCHICINA. NOTA I. CONSIDERAZIONI 

GENERALI SULL'ASPETTO, SUL COMPORTAMENTOE 

SUL SIGNIFICATO DELLA MEDESIMA. [THE INTRA- 

DERMAL REACTION TO COLCHICINE. NOTE I. 

GENERAL CONSIDERATIONS ON ITS APPEARANCE, 

BEHAVIOR AND SIGNIFICANCE]. Margin, derm., 

Fir., 1949, 4: 78-93. 

833 

Ferguson, F. C. COLCHICINE. I. GENERAL PHARMA 

COLOGY. J. Pharm. Exp. Ther., 1952, 106: 261- 

270. 12 refs. 

834 

Carotalo, F. AZIONE DELLA COLCHICINA SULLA 

RESPIRAZIONE DI ALCUNE SPECIE BATTERICHE. 

[EFFECT OF COLCHICINE ON CERTAIN BACTERIA]. 

Gior. batt. immun., 1947, 36: 102-104. 3 

refs. English summary. 

835 

Goodman, G. C. and Murray, M. R. INFLUENCE OF 

COLCHICINE ON THE FORM OF SKELETAL MUSCLE IN 

TISSUE CULTURE. Proc. Soc. Exp. Biol., N. 

1953, 84: 668-672. 15 refs. "Colchicine 

Y., 

causesTT.a breaking-up of the sarcoblastic 

ribbons into short widened segments of ap 

parently decreased consistency. 

ments remain viable." 

These seg 

836 

Grampa, G. OSSERVAZIONI COL MICROSCOPIO A 

CONTRASTO DI FASE SUL CONDRIOMA DELLE CELLULE 

EPATICHE IN REGENERAZIONE SPERIMENTALE. [OB 

SERVATIONS WITH THE PHASE MICROSCOPE ON THE 

HEPATIC CELL CHONDRIOMA IN EXPERIMENTAL RE 

GENERATION.] Boll. Soc. ital. biol. Sper., 

1951, 27: 808-809. pi. 3 refs. 

837 

Grampa, G. and Dustin, P., Jr. IMPIEGO ASSO 

CIATO DI AMINOPTERINA E COLCHICINA E ANOMALIE 

NUCLEARI; .RICERCHE SPERIMENTALI SULL' INTESTINO 

DEL TOPO. [COMBINED USE OF AMINOPTERIN AND 

COLCHICINE IN THE STUDY OF NUCLEAR ABNORMALI 

TIES; EXPERIMENTAL STUDIES ON THE INTESTINE 

IN MOUSE.) Tumori, Milano, 1953, 39: 63-71. 

14 refs. English summary. The cyÃ®ological 

alterations produced by aminopterin on mouse's 

intestine were determined by the use of col 

chicine. The findings are described. 

838 Hamperl, H. UEBER CHRONISCHE COLCHICINWIRKUNG. 

[CHRONIC EFFECT OF COLCHICINE.] Klin. & Prax., 

Munch., 1946, \\ 186-187. 7 refs. 

839 Keibl, E. and Bichlbauer, U. tJBER DIE WIRKUNG 

DES COLCHICINS AUF DIE THROMBOPOIESE. [EF 

FECT OF COLCHICINE ON THROMBOCYTOPOIESIS.] 

Klin. Med. Wien, 1949, 4: 517-522. 16 refs. 


3: No. 944. 

840 

Koskowski, W. and Mahfouz, M. THE INHIBITORY 

EFFECTS OF COLCHICINE ON THE GASTRIC SECRE 

TION PRODUCED BY HISTAMINE AND OTHER SECRE- 

TAGOGUES. J. Pharm. Exp. Ther., 1953, 109: 


Abstr., 1954, 48: 5353a. 

841 Lehmann, F. E. ÃœBERDIE ENTWICKLUNGSPHYSIO 

LOGISCHE WIRKUNG DES COLCHICINS. [THE EFFECT 

OF COLCHICINE ON DEVELOPMENTAL PHYSIOLOGY.] 

Arch. Julius Klaus Stift., 1946, 21: 305- 

307. 

842 

Â»Merlini, A. AZIONE DELLA COLCHICINA SULL'EMO 

POIESI. [EFFECT OF COLCHICINE ON HEMATOPO- 

IESIS.] Arch. Maragliano pat. clin., 1948, 

3: 1639-1692. 

843 Miszurski, B. EFFECTS OF COLCHICINE ON RESTING 

CELLS IN TISSUE CULTURES. Exp. Cell Res., 

1949, Suppl. 1, 450-451. 2 refs. 

844 Miszurski, B. and Doljanski, L. EFFECT OF COL 

CHICINE ON RESTING CELLS IN TISSUE CULTURES. 


336. Abstracted in: Excerpta med., Sect. 2, 

1948, 1: No. 2698; Chem. Abstr., 1947, 41: 

4180b.~



51 

COLCHICINE â€”¿ PHARMACOLOGICAL AND PHYSIO 

LOGICAL EFFECTS (Continued) 

845 Â»Miszurski, B. and Doljanski, !.. EFFECT OF COL- 

CHICINE ON THE RAT LIVER. 

1949, 85: 523-545. 

Am. J. Anat., 

846 Plzzetti, F. and Leonardelli, G. B. SOPRA LE 

MODIFICAZIONI INDOTTE DA COLCHICINA, COL- 

CHICOSIDE E PODOFILLOTOSSINA SUL TESSUTO 

LINFOEPITELIALE DELLA TONSILLA PALATINA. 

[CHANGES OF THE LYMPHOEPITHELIAL TISSUE OF 

THE PALATINE TONSIL BROUGHT ABOUT BY COL 

CHICINE, COLCHICOSIDE AND PODOPHYLLOTOXIN.] 

Tumori, Milano, 1953, 3jJ: 225-235. 3 reÃs. 


2: No. 3060. 

847 

Scherer, E. and Bergmann, H. BEOBACHTUNGEN 

ÃœBER DEN EINFLUSS CYTOSTATISCHER STOFFE AUF 

DIE MITOCHONDRIEN DER CARCINOMZELLE. [OB 

SERVATIONS ON THE INFLUENCE OF CYTOSTATIC 

AGENTS ON MITOCHONDRIA OF THE CARCINOMA 

CELL.] Aerztl. Forsch., 1954, 

164-167. 24 reÃs. Abstracted 

8: Originalarb; 

In: Excerpta 

med., Sect. 5, 1955, 8: No. 54. 

848 

Sternberg, S.S., Ferguson, F. C., Jr. and 

Theodore, P. S. COLCHICINE. III. PATHOLOGY 

AND HEMATOLOGY IN CATS AND RATS. Cancer, 

Phila., 1954, 7: 607-616. 9 refs. 

849 

Tufano, A. AZIONE DELLA COLCHICINA SUL PAREN 

CHIMA TIROIDEO. [EFFECT OF COLCHICINE ON THE 

THYROID PARENCHYMA.] Riforma med., 1949, 63: 

586-587. 9 reÃs. 

850 

Tuzet, O. and Durand, M. C. ACTION DE LA 

COLCHICINE SUR LA SPERMATOGENESE D'ALLOBO- 

PHORA CHLOROTICA SAV. [EFFECT OF COLCHICINE 

ON THE SPERMATOGENESIS OF ALLOBOPHORA CHLO 

ROTICA SAV.] C. rend. Acad. sc., 1949, 228: 

1055-1057. 2 refs. 

851 

Â«Widmann, H. LEUKOPENIE, EINE VORAUSSETZUNG DER 

fcEUKOCYTOSE? TIEREXPERIMENTELLE UNTERSUCHUNGEN 

ÃœBER DIE WIRKUNG KLEINER COLCH1CINDOSEN AUF DAS 

WEISSE BLUTBILD. [IS LEUCOCYTOSIS PRECEDED BY 

LEUCOPENIA? ANIMAL EXPERIMENTS ON THE INFLUENCE 

OF SMALL COLCHICINE DOSES ON THE WHITE BLOOD 

PICTURE.] Aerztl. Forsch., 1949, 3: 86-92. 

85 Widmann, H. ZUR DEUTUNG DER LEUKOPENISCHEN 

PHASE NACH COLCHICIN. [INTERPRETATION OF 

LEUKOPENIC PHASE FOLLOWING COLCHICINE AD 

MINISTRATION.] Klin. Wschr., 1950, 28: 

132-133. 11 refs. 

See 

23 432 

2235 

RESISTANCE 

829 881 2213 

TO 

853 

Bretscher, A. GENETISCH BEDINGTE UNTERSCHIEDE 

IN DER COLCHICIN-EMPFINDLICHKEIT BEI HÃœHNERN. 

[GENETIC DIFFERENCES IN THE SENSITIVITY OF 

(DIFFERENT BREEDS) OF HENS TO COLCHICINE.] 

Arch. Julius Klaus Stift., 1951, 26: 465-469. 

854 

Lettre, H. and Kramer, W. EINE GEGEN COLCHICIN 

RESISTENTE ABART DES MXUSE-ASCITESTUMORS. [A 

COLCHICINE-RESISTANT FORM OF MOUSE ASCITES 

TUMOR.] Naturwissenschaften, 1952, 39: 117. 

12 refs. Abstracted in: Chem. AbstrTV 1953, 

47: 1274f. 

See 

2553a 

THERAPY 

855 

Broun, G. O., Hager, V., Goehausen, M. C., 

Grebel, C. B., Sweeney, W. M. and Hellmann, 

B. H. REMISSION IN HODGKIN'S DISEASE FOLLOW 

ING COLCHICINE, DESOXYCORTICOSTERONE AND 

ASCORBIC ACID. J. Laborat. Clin. M., 1950, 

36;. 803-804. An abstract. 

856 

Chevallier, P. and Colin, M. VASTE EPITHELIOMA 

BASOCELLULAIRE TRAITE LOCALEMENT PAR LA COL 

CHICINE. [EXTENSIVE BASAL CELL EPITHELIOMA 

TREATED LOCALLY WITH COLCHICINE.] Ann. derm, 

syph., Par., 1946, 6: 297-298. 

857 Constantin, P. FAUT-IL ASSOCIER LES INJECTIONS 

DE COLCHICINE X LA RADIOTHÃ‰RAPIE DANS LE 

TRAITEMENT DU CANCER7 [SHOULD COLCHICINE IN 

JECTIONS BE ASSOCIATED WITH ROENTGENOTHERAPY 

IN THE TREATMENT OF CANCER?] J. radiol. 

e'iectr., 1946, 2J7: 466-467. 

858 

Costabile, L. MODERNI TRATTAMENTI DELLE LEU 

CEMIE. [MODERN THERAPIES OF THE LEUCEMIAS.] 

Diagnosi, Nap., 1948, 4: 426-434. 

859 

Eichler, P. DIE VERWENDUNG VON COLCHICIN IN 

DER THERAPIE OBERFLÃ„CHLICHER CARCINOME. 

[COLCHICINE TREATMENT OF SKIN CARCINOMA.] 

Deut. Gesundhwes., 1947, 2: 351-353. 

3 refs. English summary. 

860 

Erti, E. KOMBINIERTE FIEBEH-COLCHICIN-RONT- 

GENTHERAPIE BEI KREBS DES KEHLKOPFES UND 

DES KEHLRACHENS. [COMBINED FEVER-COLCHI- 

CINE-ROENTGEN THERAPY IN CANCER OF THE 

LARYNX AND THE PHARYNX]. Arch. Ohr. fcc. 

Heilk., 1951, 159; 165-172. 23 refs. 

861 

Gardini, G. F. and Rizzente, S. LA NOSTRA 

ESPERIENZA CLÃ•NICA CON UN ALCALOIDE DEL 

COLCHICUM AUTUNNALE. [PERSONAL CLINICAL 

EXPERIENCE WITH A COLCHICUM AUTUNNALE 

ALKALOID.] Tumori, Milano, 1954, 40: 

625-637. 8 refs. "Good results in the 

treatment of skin tumors have been ob 

tained by an 

(colcemid)." 

alcaloid of colchicum 

862 

Girgis, A., Martin, J. F., Orsoni, D. and 

Ponthus, P. RÃ‰SULTATS DE L'ASSOCIATION 

COLCHICÃ•NE-RADIOTHERAPIEDANS LE TRAITE 

MENTDES TUMEURSMALIGNES. [RESULTS OF 

ASSOCIATEDCOLCHICINE ANDROENTGEN 

THERAPYOF MALIGNANTTUMORS.] J. radiol. 

Ã©lectr., 1946, 27: 244-246. 2 refs. 

Of 36 cases treÃ¤Ted, 8 seemed to profit 

by combined therapy. 

863 

Grant, A. P. LEUKAEMIA TREATED WITH COLCHICINE. 

Irish J. M. Sc., 6. ser., 1954, No. 347, 497- 

500. 13 refs. 

864 

Grixoni, F. RICERCHE ISTOCHIMICHE SUL METABO 

LISMO DEGLI ACIDI NUCLEI N U) 1 NEGLI EPITELIOMI 

BASOCELLULARI CUTANEI TRATTATI CON APPLICA 

ZIONI EPITOPICHE DI COLCHICINA. [HISTOCHEMI- 

CAL RESEARCH ON THE METABOLISM OF NUCLEIC ACIDS 

IN COLCHICINE-TREATED SKIN BASOCELLULAR EPITHE- 

LIOMAS.] Minerva derm., Tor., 1953, 28: 6-10. 

Abstracted in: Chem. Abstr., 1954, 43: 3569b. 

865 

Heep, W. COLCH1CINSALBE IN DER BEÃ•ANDLUNG 

OBERFLÃ„CHLICHER KARZINOME. [COLCHICINE 

OINTMENT IN THE TREATMENT OF SUPERFICIAL 

CARCINOMAS.] Deut. med. Wschr., 1949, 

74: 971-972.



52 

COLCfflCINE 


(Continued) 

866 

Huant, E. ACTION DE LA COLCHICINE ASSOCIÃ‰EA 

LA RADIOTHÃ‰RAPIEDANS LE TRAITEMENT DES TU 

MEURS MALIGNES. [THE EFFECT OF COMBINED X- 

RAT AND COLCHICINE TREATMENT IN MALIGNANT 

TUMORS]. 

1953 9: 

Acta 

85-93. 

UniÃ³ internat, cancr., Louvain, 

867 

Huant, E. ACTION DE LA COLCHICINE ET DE LA 

RADIOTHÃ‰RAPIE EN MILIEU BIOLOGIQUE MODIFIÃ‰. 

[THE EFFECT OF COLCHICINE AND RADIOTHERAPY 

UNDER 

hop., 

ALTERED BIOLOGICAL CONDITIONS]. 

1953, 126: 373-379. 

Gaz. 

868 

Huant. E. A PROPOS DES CHIMIOTHÃ‰RAPIES ANTI- 

CANCÃ‰REUSES;L'ASSOCIATION COLCHICINE-RADIO- 

THERAPIE, PRESENTATION DE DOCUMENTS ET RÃ‰ 

SULTATS ELOIGNES. COMPARAISON AVEC D'AUTRES 

AGENTS CHIMIQUES ET ETAT ACTUEL DE LA QUES 

TION. [CHEMOTHERAPY OF CANCER; ASSOCIATION 

OF COLCHICINE AND RADIOTHERAPY, PRESENTATION 

OF DATA ON REMOTE RESULTS, COMPARATIVE 

STUDIES WITH OTHER CHEMOTHERAPEUTIC AGENTS, 

AND CONSIDERATIONS ON THE PRESENT STATE OF 

THE PROBLEM.] ThÃ©rapie, Par., 1953, 8: 

588-597. 5 refs. 

869 Isch-Wall, P. QUATRE CAS DE MALADIE DE HODGKIN 

TRAITES PAR LA COLCHICINE. [COLCHICINE TREAT 

MENT IN FOUR CASES OF HODGKIN>S DISEASE.] 

Sang, Par., 1952, 23: 689-693. 

870 

Keibl, E. BEMERKUNGEN ZUR COLCHICIN-THERAPIE 

BEI BLUTKRANKHEITEN. [COLCHICINE THERAPY OF 

DISEASES OF THE BLOOD.] Wien, Klin. Wschr., 

1950, 62: 203-206. 12 refs. 

871 

Keibl, E. UEBER DAS DIFFERENTE VERHALTEN VON 

COLCHICIN UND COLCEMID (DEMECOLCIN) IN DER 

THERAPIE CHRONISCHER MYELOSEN. [THE DIFFERENT 

BEHAVIOR OF COLCHICINE AND COLCEMID (DEMECOL- 

CINE) IN THE THERAPY OF CHRONIC MYELOSIS.] 

Wien. klin. Wschr., 1955, 67: 511-515. 10 refs. 

872 

Keibl, E. and Lotsen, A. BEOBACHTUNGEN ÃœBER 

EINE KOMBINIERTE COLCHICIN-RÃ–NTGENTHERAPIE 

BEI LEUKÃ„MIE. [COMBINED COLCHICINE-X-RAY 

THERAPY IN LEUKEMIA.] Schweiz, med. Wschr., 

1950, 80: 228-231. 8 refs. 

873 

Morel, A. and Josserand, A. LA THÃ‰RAPEUTIQUE 

ANTI-OEDÃ‰MATEUSE ASSOCIÃ‰E AUX CHIMIOTHERAP;ES 

CELLULICIDES PALLIATIVES DES CANCERS EPITHE- 

LIAUX. [ANTI-EDEMATOUS TREATMENT COMBINED 

WITH THE PALLIATIVE TREATMENT OF CARCINOMAS 

BY CELLULICIDAL 

med., 1952, 60: 

CHEMICAL 

490-492. 

AGENTS.] 

9 refs. 

Presse 

Abstracted 


874 llugler, A. and Kempf, I. ACTION REMARQUABLE DE 

LA COLCHICINE DANS UN CAS DE PRURIT HODGKINIEN 

PROLONGE. [REMARKABLE EFFECT OF COLCHICINE 

ON LONG-STANDING PRURITUS IN A CASE OF HODGKIN'Ã• 

DISEASE.] Strasbourg mÃ©d., 1953, 4: 601-60a 

4 refs. 

875 

Nelson, L. M. EFFECT OF LOCALLY INJECTED COL 

CHICINE ON CARCINOMAS. A.M.A. 

1951, 63: 440-442. 14 refs. 

Arch Derm., 

876 

Radalli, G. AZIONE DELLA COLCHICINA SUGLI EPI 

TELIOMI CUTANEI SUPERFICIALI. [THE EFFECT OF 

COLCHICINE ON SUPERFICIAL CUTANEOUS EPITHE- 

LIOMAS.] Gior. ital. derm, sif., 1948, 89: 

1118-1129. Results in 13 cases. 

877 

Reviglio, J. M. X PROPOS DE L'ASSOCIATION COL- 

CHICINE-ROENTGENTHÃ‰RAPIE DANS LE TRAITEMENT 

DES TUMEURS MALIGNES. [COMBINED COLCHICINE- 

X-RAY TREATMENT OF MALIGNANT TUMORS.] Radiol 

clin., Basel, 1948, 17: 149-155. English 

summary. 

878 

Sentein, P. L'ASSOCIATION DE LA COLCHICINE 

Ã€LA RADIOTHÃ‰RAPIEDANS LA THÃ‰RAPEUTIQUEDES 

TUMEURS MALIGNES. [COMBINED TREATMENT OF 

MALIGNANT TUMORS WITH COLCHICINE AND ROENTGEN 

RAYS.] J. radiol. electr., 1946, 27: 540- 

541. 20 refs. 

879 

Tillier, H. and Dumazer, R. COLCHICINE ET 

TRAITEMENT RADIOTHÃ‰RAPIQUEDU CANCER. [COL 

CHICINE AND RADIOTHERAPY TREATMENT OF CANCER.] 

Bull, algÃ©r. carcin., 1948, 1: 157-159. 

Abstracted in: Index analyt."cancer. Par., 

See 

753 

1948, 19: No. 651. 

THERAPY, ENHANCEMENT 

880 Hirsch, H. ÃœBERDIE WIRKUNGSSTEIGERUNG VON COL 

CHICIN DURCH GLEICHZEITIGE ANWENDUNGVON BULBO- 

CAPNIN BEI DER BEHANDLUNG VON HAUTKREBSEN. 

[INCREASED EFFECT OF COLCHICINE BY SIMULTANEOUS 

ADMINISTRATION OF BULBOCAPNINE IN THE TREAT 

MENT OF SKIN CANCER.] Derm. Wschr., 1951, 

123: 389-390. 2 refs. 

TOXICITY 

881 

Balduini, M. and Bertolottl, G. SANGUE PERI 

FERICO E MIDOLLO OSSEO NELLA INTOSSICAZIONE 

SPERIMENTALE DA COLCHICINA. [THE PERIPHERAL 

BLOOD AND THE BONE MARROWIN EXPERIMENTAL 

POISONING WITH COLCHICINE]. 

Pavia, 1948, 31: 65-84. 20 

Haematologica, 

refs. 

882 

Chiti, E. MODIFICAZIONI NEL MIDOLLO OSSEO IN 

RAPPORTO A INTRODUZIONE DI COLCHICINA PER VIA 

ENDOVENOSA IN SOGGETTI SANI. [BONE-MARROW 

CHANGES FOLLOWING INTRAVENOUS INJECTION OF 

COLCHICHINE IN HEALTHY SUBJECTS.] Arch. 

Maragliano pat. clin., 1947, 2: 518-524. 

1 fold, chart. 12 refs. Abstracted in: 


883 

Cornman, I. ALLEVIATION OF MITOTIC POISONING 

BY GLUCOSE. J. Cellul. 

301-302. 2 refs. 

Physiol., 1950, 35: 

884 

Fagraeus, A. and Gormsen, H. THE EFFECT OF 

COLCHICINE ON CIRCULATING ANTIBODIES, ANTI 

BODY PRODUCING TISSUES AND BLOOD CELLS IN 

RAT. Acta path, microb. scand., 1953, 33: 


med., Sect. 5, 1954, 7: No. 3673. 

885 

Kellner, B. and Matko, L. THE EFFECTS OF ACUTE 

AND CHRONIC 

OF THE RAT. 

COLCHICINE POISONING ON THE ORGANS 

Acta morph. hung., 1953, 3: 125- 

148. 42 refs. The effects of colchicine in 

sublethal and chronic doses were studied in 

30 mice. Histological changes in organs in 

which mitotic forms abound were observed. 

Division of cells is arrested in the metaphase. 

The changes appear rapidly and disappear in 

a short time. Edema, distention of sinus, 

secretion of mucus are some of the changes 

which occur as early as 30 to 60 minutes 

following administration. Maximum effect in 

nuclear changes is reached 72 hours after 

colchicine administration. Fibrosis of bone 

marrow, hyperplasia of reticulum, giant cell 

formation are some of the permanent effects 

following chronic colchicine administration.



53 

COLCHICINE 

â€”¿ TOXICITY (Continued) 

886 Lambers, K. 'ÃœBERORGANVERANDERUNGEN BEI CHRONI 

SCHER COLCHICINVERGIFTUNG. [ORGANIC CHANGES 

ASSOCIATED WITH CHRONIC COLCHICINE POISONING.] 

Virchows Arch., 1951,321: 88-100. Approx. 


2, 1952, 5: No. 5589; Chem. Abstr., 1952, 46: 

887 

Layani, F., Aschkenasy, A. and Mouzon, M. IN 

TOXICATION AIGUÃ‹ PAR LA COLCHICINE. IMPOR 

TANTES ALTERATIONS DE LA LEUCOPOIÃˆSE. [ACUTE 

COLCHICINE POISONING. SERIOUS INTERFERENCE 

WITH LEUCOPOIESIS.] Bull. Soc. mÃ©d. hop. 

Paris, 1947, 63: 10-16. 4 refs. Abstracted 


888 

Poe, C. F. and Johnson, C.C. TOXICITY OF COL 

CHICINE, PILOCARPINE. AND VERATRINE. 

pharm. tox., Kbh., 1949, 5: 110-120. 

Acta 

5 refs. 

Abstracted in: Chem. Abstr., 1950, 44: 1194e. 

889 

Rossi, S. STEATOSI PARENCHIMALI DA COLCHICINA- 

DIFFERENZA DI SENSIBILITÃ€ DEI DUE SESSI IN 

ANIMALI INTOSSICATI. [FATTY DEGENERATION 

DUE TO COLCHICINE; SEX DIFFERENCES IN SENSI 

TIVITY IN POISONED ANIMALS.] Experientia 

Basel, 1950, 6: 306-307. Abstracted in: 


89p 

Santavy, F., Lang, B. and Malinsky J. TOXICITA 

NOVYCH LATER, VYISOLOVANYCH Z OCUNU JESENNÃ•HO 

(COLCHICUM AUTUMNALE L.). [THE TOXICITY OF 

NEW SUBSTANCES DERIVED FROM COLCHICUM AUTUMNALE 

L.] Cas. lek. Ãesk., 1949, 88: 59-62. 25 refs. 

French summary. 

623 626 786 

2819 3560a 

794 833 

- TOXICITY, COUNTERACTION TO 

See 

755 

COLCHINE ANALOGS â€”¿ EFFECT ON NORMAL 

GROWTH 

891 

LettrÃ©, H. and Hartwig, E. VERGLEICH RINGGE 

SCHLOSSENER UND RINGOFFENER VERBINDUNGEN VOM 

COLCHICINTYP AUF IHRE ANTIMITOTISCHE WIRKUNG. 

[COMPARISON OF ANTIMITOTIC EFFECT OF COLCHI 

CINE COMPOUNDS WITH CLOSED AND OPEN RINGS.] 

Hoppe Seyler Zschr., 1952, 291: 164-168. 

Abstracted in: Biol. Abstr .7~T953, 27: No. 

27706. "Structural analogs of colcETcine 

methyl ether and similar antimitotic com 

pounds. alpha- and beta-[3-methoxyphenyl]- 

gamma- [3,4, 5-tr imethoxyphenyl ]-propylamine , 

were synthesized and proved inactive on fibroblasts." 

- Biol. Abstr. 

COLCHICINE 

DERIVATIVES 

892 

Akaishi, K., Chiba. K. and Sato, K. EFFECT OF 

COMPOUNDS HAVING UNSATURATED SEVEN MEMBERED 

RING STRUCTURE ON YOSHIDA SARCOMA. 3RD RE 

PORT. Gann, Tokyo, 1954, 45: 507-510. 

In English. The action of 9 compounds, chiefly 

colchicine derivatives, on mitosis were stud 

ied in vitro; thiocolchicine showed the strong 

est effect and was 2.5 times more effective 

than colchicine. 

893 Rutten, A. M. G. MITOSEGIFTEN UIT DE COLCHICUM 

GROEP. [MITOTIC POISONS FROM THE COLCHICINE 

GROUP.] Chem. pharm. techn., 1954, 9: 355- 

356. 5 refs. 

894 

Leiter, J., Hartwell, J. L., Ullyot, G. E. and 


*ITH CHEMICAL AGENTS. V. DERIVATIVES OF 

COLCHICINE AND ISO-COLCHICINE. J. Nat. Cancer 

Inst., 1953, 13J 1201-1211. 31 refs. 

895 

Soave, F. VARIAZIONI CARIOMETRICHE DA COLCHI 

CINA NEL FEGATO; RICERCHE SPERIMENTALI 

[CARYOMETRIC VARIATIONS OF COLCHICINE IN THE 

LIVER; EXPERIMENTAL RESEARCH.] Neoplasie 

Tor., 1948, 3: 253-258. 18 refs. A colchi 

cine derivative (C22H2506N) in doses of 0.003- 

0.1 g was given to 15 guinea pigs. By the 

caryometric technique of di Macco a steady 

decrease in the size of nuclei of the liver 

tissue was observed. 

896 

Huguenin, R., Truhaut, R. and Saracino, R. 

PREMIERS RÃ‰SULTATSDE L'UTILISATION EN CHIMIO 

THERAPIE ANTICANCEREUSE D'UN DÃ‰RIVÃ‰DE LA 

COLCHICINE: LA N-DÃ‰SACÃ‰TYL-THIOCOLCHICINE. 

[PRELIMINARY RESULTS OF THE USE OF A DERIVA 

TIVE OF COLCHICINE IN CANCER CHEMOTHERAPY: 

THE N-DESACETYL-THIOCOLCHICINE.] Bull. Ass. 

fr. Cancer, 1955, 42: 308-325. 17 refs. 

COLCHICINE, 

DESACETYL- 

897 

Lenti, G., Tortarolo, E., Vaglio, G., Zaina, p. 

and Musolino, G. AZIONE DELLA DEACETILCOLCHI- 

CINA SU CULTURE DI FIBROBLASTI IN VITRO. 

[ACTION OF DEACETYLCOLCHICINE ON FIBROBLAST 

CULTURE IN VITRO.} Minerva med., Tor., 1955, 

46: 13-18. 17 reÃs. Deacetylcolchicine in 

amounts of 0.4 mg. exercises a metaphase 

block on fibroblast cultures. 

898 

Paolino, W., Pierri, G. and Resegotti, L. 

RICERCHE SPERIMENTALI E PRIME APPLICAZIONI 

CLINICHE CON UN DERIVATO COLCHICINICO AD 

AZIONE ANTIBLASTICA: L'ESTERE METILICO 

DELL'ACIDO TRIMETILCOLCHICINICO (DEACETIL- 

COLCHICINA). [EXPERIMENTAL STUDY AND FIRST 

CLINICAL APPLICATION OF A COLCHICINE DERI 

VATIVE WITH ANTIBLASTIC ACTION: METHYL 

ESTER OF TRIMETHYLCOLCHICINIC ACID (DEACE 

TYLCOLCHICINE).] Minerva med., Tor., 1955, 

46: 1-12. 12 refs. Thirty-seven case 

ETstories are discussed. This derivative is 

more antiblastic and less toxic than other 

colchicine derivatives. 

899 

Resegotti, L. and Euler, H. -von STUDIO SULLE 

MITOSI NEL TUMORE ASCITE DEL RATTO PER SOM 

MINISTRAZIONE DI ESTERE METILICO DELL'ACIDO 

TRIMETILCOLCHICINICO DA SOLO OD ASSOCIATO A 

FLORIZZINA. [MITOSIS IN THE ASCITES TUMOR 

IN THE RAT AFTER ADMINISTRATION OF TRIMETHYL 

COLCHICINIC ACID METHYL ESTER ALONE OR IN 

COMBINATION WITH PHLORHIZIN.] 

1955, 4l: 168-180. D-tartrate 

Tumori, Milano, 

of trimethylcolchicTnic 

acid methyl 

doses of 2-32 mg/kg was 

ester(NCI 1136) in 

administered to rats 

with ascite tumors. Following a brief in 

crease in the mitotic index, the mitosis 

begins to be blocked. Phloridzine prolongs 

and enhances the mitotic blockings. 

900 

Vermel", E. M. and Kramorenko, I. T. PERVYÃ• 

UPYT LECHENIÃ•A OMAINOM RAKA KOZHI. [FIRST 

EXPERIMENT OF OMAIN TREATMENT OF CUTANEOUS 

CANCER.] Vopr. 

69-74. 7 refs. 

onkol., 

Omain, 

1955, 

a new 

\\ No. 4, 

colchicine 

alkaloid, also called deacetylcolchicine, 

was applied in the form of an ointment to 

50 patients with cutaneous cancer. No lysis 

of either the normal or malignant tissue 

occurred. The cosmetic effects were ex 

cellent.



54 

COLCHICINE, DESACETYLMETHYL-, â€”¿EFFECT 


901 

Albrecht. H. CHROMATINFREIE CYTOPLASMATEILUNG 

VON PROMYELOCYTEN UND MYELOCYTEN UNTER EIN 

WIRKUNG VON MITOSEGIFTEN IN VITTKX. [CROMATIN- 

FREE DIVISION OF CYTOPLASMS OF PROHYELOCYTES 

AND MYELOCYTES UNDER THE INFLUENCE OF MITOTIC 

POISONS IN VITRO.] 

60: 16-8. 9 reÃs. 

Zschr. Krebsforsch., 1954, 

902 

Albrecht, M. UNTERSUCHUNGEN ÃœBER DIE MITOSE 

HEMMENDE WIRKUNG VON DEMECOLCIN AUF MENSCH 

LICHES KNOCHENMARK IN VITRO. [STUDIES ON 

THE ANTIMITOTIC EFFECTS OF DEMECOLCINE ON 

HUMAN BONE MARROW IN VITRO.] Acta haemat., 

Basel, 1955, 13: 8-13. 8 refs. 

903 Lichtman, A. THE EFFECT OF DEMECOLCIN (DES- 

METHYLCOLCHICINE) ON THE PERIPHERAL BLOOD 

AND BONE MARROW IN THE RABBIT AND CAT. 23p. 

Zurich, Fluntern, 1954. (Inaug.-Diss.- 

Zurich.) 

904 

Meier, R., SchÃ¤r, B. and Nelpp, L. DIE WIRKUNG 

VON DEMECOLCEINAMIDEN AN ZELLEN IN VITRO. 

[THE EFFECT OF DEMECOLCEINAMIDES ON CELLS IN 

VITRO.] Experientia, Basel, 1954, 10: 74-76. 

7 refs. "A series of demecolceinamlefes was 

examined in vitro on chicken fibroblasta, 

leucocytes, and different bacteria. It was 

found that with increasing length of the side 

chain ring C the antimitotic activity is de 

creasing while the antibacterial effect is 

Increasing." 


905 SchÃ¤r, B., Loustalot, P. and Gross, F. DEME 

COLCIN (SUBSTANZ F), EIN NEUES, AUS CQLCHICUM 

AUTOMNALE ISOLIERTES ALKALOID MIT STARKER 

ANTIMITOTISCHER WIRKUNG. [DEMECOLCIN (SUB 

STANCE F), A NEW ALKALOID WITH STRONG ANTI 

MITOTIC ACTIVITY FROM COLCHICUM AUTOMNALE. ] 


THERAPY 

906 

BOCK, H. E. and Gross, R. LEUKÃ„MIE- UND TUMOR 

BEHANDLUNG MIT EINEM NEBENALKALOID AUS COL- 

CHICUH AUTUMNALE (DEMECOLCIN). [AN ALKALOID 

FROM COLCHICUM AUTUMNALE (DEMECOLCIN) IN THE 

TREATMENT OF LEUKEMIA AND TUMORS.] Acta 

haemat., Basel, 1954, 11: 280-300. 38 refs. 

"In chronic myeloid leucaemia the substance 

is efficacious, well tolerated and relatively 

safe from the point of view of complicating 

blood dyscrasias, but in various tumours, 

acute myeloid leukaemia and chronic lymphatic 

leukaemia its efficacy is very variable and 

it endangers granulocytopoiesis." 

907 

Bock, H. E. and Gross, R. ZUR THERAPIE DER 

CHRONISCHEN MYELOISCHEN LEUKÃ„MIE. [THE 

THERAPY OF CHRONIC MYELOID LEUKEMIA]. 

Aerztl. Â»sehr., 1954, 9: 344-345. 12 refs. 

Abstracted in: Leukemia Abstr., 1954, 2- 

No. 817. 

908 

Fromowicz, K. K. SPOSTRZEZENIA NAD LECZNICZYM 

WPLYWEMDEMEKOLCYNYW PRZEWLEH.YCH BIAtACZKACH 

GRANULOCYTOWYCH. [OBSERVATIONS 

PEUTIC EFFECT OF DEMECOLCINE IN 

ON THE THERA 

CHRONIC GRA- 

NULOCYTIC 

1955, 10: 

LEUKEMIA.] 

602-604. 5 

Polski 

refs. 

tygod. lek., 

909 

Gardini, G. F. NOS EXPÃ‰RIENCESCLINIQUES AVEC 

UN NOUVEL ALCALOÃ•DEEXTRAIT DU COLCHICUM AUTUM 

NALE. [CLINICAL EXPERIENCE WITH A NEW ALKALOID 

EXTRACT FROM COLCHICIÂ« AUTUMNALE.] 

Basel, 1954, 7: 105-106. 

Oncologia, 

910 Gigante, D. DE L'ACTION THERAPEUTIQUE DE LA 

COLCEMIDE (DEMECOLCINE), DERIVE DU COLCHICUU 

AUTUMNALE, DANS LE CAS D'HEMOPATHÃ•ES MALIGNES 

CHRONIQUES. [THERAPEUTIC EFFECT OF COLCEMIDE 

(DEMECOLCINE), DERIVATIVE OF COLCHICUM AUTUM 

NALE, 

Sang, 

IN CHRONIC MALIGNANT BEMOPATHIES.] 

Par., 1955, 26: 404-422. 1 pi. 12 

refs. Extensive report based on 50 case 

historiÃ©s. 

911 LÃ©onard, B. J, and Wilkinson, J. F. DESACETYL- 

METHYLCOLCHICINE IN TREATMENT OF MYELOID 

LEUKAEMIA. Brit. M. J., 1955, No. 4918, 874- 

877. 7 refs. 

912 

Leonardi, P. and D'Agnolo, B. SULLA TERAPIA 

DELLE LEUCEMIE E DEL MORBO DI HODGKIN CON 

DESACETILMETILCOLCHICINA ALCALOIDE ANTIMI- 

TOTICO DEL COLCHICO AUTUNNALE. [TREATMENT 

OF LEUKAEMIA AND OF HODGKIN'S DISEASE WITH 

DESACETYLMETHYLCOLCHICINE, AN ANTIMITOTIC 

ALKALOID FROM C. AUTUMNALE.] Acta med. 

patav., 1954, 14: 69-109. 13 refs. 

Abstracted in:~Excerpta med., Sect. 16, 

1955, 3: No. 1847. 

913 Moeschlin, S., Meyer, H. and Lichtman, A. A 

NEW COLCHICINE DERIVATIVE (DEMECOLCIN CIBA) 

AS A CYTOSTATIC AGENT IN MYELOGENOUS LEUKE 

MIA. In: Ciba Foundation Symposium on leu 

kemia research, London, 1953, (Walstenholme, 

G. E. W. and Cameron, M. P., eds.). Boston, 

Little, Brown and Co., 1954, 216-230. 10 

refs. 

914 

Moeschlin, S., Meyer, H. and Lichtman, A EIN 

NEUES COLCHICUM-NEBENALKALOID (DEMECOLCIN 

CIBA) ALS CYTOSTATICUMMYELOISCHERLEUKÃ„MIEN 

[A NEWCOLCHICUMALKALOID (DEMECOLCINCIBA) 

AS A CYTOSTATIC IN MYELOGENOUSLEUKEMIA]. 

Schweiz, med. Wschr., 1953, 83: 990-994. 

7 refs. Abstracted in: Excerpta ned., Sect 

48: 16, 4107a.~ 1954, 2: No. 5133; Chem. Abstr , 1954 

915 

Pribilla, W. and Stollberg, G. DIE BEHANDLUNG 

MYELOISCHERLEIKÃ„MIENMIT MYLERANUNDDEME 

COLCIN. [THE TREATMENTOF MYELOCYTICLEUKE- 

MIAS WITH MYLERANANDDEMECOLCIN.] Deut. 

med. Wschr., 1955, 80: 1027-1029. 11 refs. 

916 Â«Storti, E. and Gallinelli, R. RISULTATI DEL 

TRATTAMENTO DI EMOBLASTOSI I,INFOII)!CON LA 

SOSTANZA F ESTRATTA DAL COLCHICUM AUTUMNALE. 

[RESULTS IN THE TREATMENT OF LYMPHOID HEMO- 

BLASTOSIS WITH SUBSTANCE F AN EXTRACT OF 

COLCHICUM AUTUMNALE.] Gior. ital. chemioter., 


Â»ed., Sect. 16, 1955, 3: No. 2753. 

917 

Storti, E. and Gallinelli, R. TRAITEMENT DES 

HÃ‰MOBLASTOSES LYMPHOÃ•DES,PAR UN NOUVEAU ALCA 

LOÃ•DE COLCHIQUE: LA "DEMECOLCINE." [THERAPY 

OF LYMPHOID HEMOBLASTOSES WITH A NEW COLCHI 

CINE DERIVATIVE: "DEMECOLCINE."] Schweiz, 

med. Wschr., 1954, 84: 612-615. 8 refs. 


3: No. 563. 

918 

*Volterra, M., Romualdi, G. and Abbozzo, G. 

SULL'IMPIEGO DELLA DESACETILMETILCOLCHICINA 

NELLA 

PATIE 

TERAPIA DELLE LEUCEMIE, 

E DI ALCUNE NEOPLASIE. 

DI ALTRE EMO 

[THE USE OF 

DEACETYL-N-METHYLCOLCHICINE IN THE TREAT 

MENT OF LEUKEMIA, OTHER BLOOD DISEASES AND 

SOME NEOPLASMS.] Gior. clin, med., 1955, 

36: 651-668. 

See 

871



55 

COLCHICINE, DESMETHYL-, â€”¿ PHARMACOLOGI 

CAL AND PHYSIOLOGICAL EFFECTS 

919 Peterfalvi, II. and Jequier, R. ETUDE PHARMA- 

COLOGIQUE DE TROPAMI NONES DÃ‰RIVÃ‰ES DE LA 

COLCHICINE. DE LA DESMETHYLCOLCHICINE ET DU 

COLCHICOSIDE. [PHARMACOLOGICAL STUDY OF THE 

TROPAMINONE DERIVATIVES OF COLCHICINE: DES- 

METHYLCOLCHICINE 

internat, pharm. 

AND COLCHICOSIDE.] 

dyn., Par., 1954, 

Arch, 

98: 236- 

241. 

See 

920 

COLCHICINE, 

See 

ISO- 

747 784 894 

COLCHICINIC ACID, TRIMETHYLsee 

COLCHICINE, 

DESACETYL- 

COLCHICOSIDE 

920 Jequier, R. and PÃ©terfalvi, M. ETUDE PHARMA- 

COLOGIQUEDU COLCHICOSIDE ET DE SON AGLUCONE, 

LA DESMETHYL-COLCHICINE. [THE PHARMACOLOGY 

OF COLCHICOSIDE AND ITS AGLUCONE,DEMETHYL- 

COLCHICINE.] Arch, internat, pharm. dyn., 

Gand., 1953, 94: 453-459. 9 refs. Abstracted 

in: Chem. AbsÃ¯r., 1954, 48: 1566d. 

921 Rossito, O. L'AZIONA ANTIBIOTICA DEL COLCHICO 

SIDE (DESMETILCOLCHICINA). I. NOTASPERI 

MENTALE. [ANTIMITOTIC ACTION OF COLCHICOSIDE 

(DESMETHYLCOLCHICINE). I. EXPERIMENTALOB 

SERVATIONS.] Gior. ital. chemioter., 1954, 

1: 87-94. 

See 

919 

COLCHINOL, 

N-ACETYLJODO- 

922 

MacCardle. R. C. EFFECTS OF MITOTIC INHIBITORS 

ON TUMOUR CELLS. Ann. N. York Acad. Sc., 1951, 

51; 1279-1546. 23 refe. The effects of N- 

acetyliodocolchinol methyl ether and podophyllin 

on sarcoma 37 cells are described and 

compared with those produced by colchicine, 

trypaflavine and arsenic. The most diverse 

agents can provoke similar alterations in 

mitosis. The changes do not seem to be pecu 

liar to any particular agent studied but are 

apparently governed by dose. 

COMPOUND 48/80 (p-METHOXYPHENETHYL-METHYL- 

AMINE FORMALDEHYDE) 

Mota, I., Beraldo, W. T. and Junqueira, L. C. U. 

PROTAMINELIKE PROPERTY OF COMPOUND 48/80 AND 

STILBAMIDINE AND THEIR ACTION ON MAST CELLS. 


457. 12 refs. 

CONIFERS 

926 Taylor, A., McKenna, G. F. and Burlage, H. M. 

CANCER CHEMOTHERAPY EXPERIMENTS WITH PLANT 

EXTRACTS. Texas Rep. Biol. M., 1952, 10: 

1062 1074. 10 refs. More than 250 plant 

extracts have been tested. "An aqueous ex 

tract of yucca roots and a hot aqueous ex 

tract of leaves and stems of poison ivy 

inhibited tumor and embryo growth to about 

the same degree as aminopterin. An alcohol 

extract of yucca roots and acid and acetone 

extracts of April rain lily bulbs inhibited 

tumor growth in the aminopterin range with 

out affecting the growth of the embryo." 

COPPER 

927 KÃ©rangal, Y. de SUR LE TRAITEMENT DES NÃ‹OPLA- 

SIES PAR LES THERMIONS METALLIQUES DE CUIVRE. 

[THE TREATMENT OF CANCER WITH COPPER THER 

MION INSUFFLATIONS.] J. med. 

67: 173-176. Descriptions of 

Paris, 1947, 

5 cases with 

Beneficial effect of treatment. 

See 

1813 

COPPER 

See 

928 

COPPER 

GLUTAMATE 

NICOTINATE 

928 

Grinberg, R. and Correa Urquiza, L. M. ACCIÃ“N 

DEL NICOTINATO Y GLUTAMATO DE COBRE SOBRE EL 

SARCOMA DE ROFFO DE LA RATA. [EFFECT OF 

COPPER NICOTINATE AND GLUTAMATE ON ROFFO 

SARCOMA IN THE RAT.] Sem. med., B. Air., 

1949, 56: 265-268. 10 refs. Copper nicotinate~produced 

a 25% tumor regression while 

copper glutamate had no effect on the sar 

coma growth. 

COURAMIN 

See 

3271 

CROCI, TINCTURE OF 

929 

Janousek, F. SPONTÃ•NNI VYLÃ‰CENÃ•RAKOVINY A 

TERMONY. [SPONTANEOUS HEALING OF CANCER 

AND TERMONES.] Lek. listy, 1947, 2: 579- 


1949, 2j No. 1414. "A short survey of spon 

taneous" healing of cancer. Tincture of 

croci, probably containing termones, and 

chemically similar to protocrocin, is re 

commended 

of cancer 

as an adjuvant in the treatment 

and lymphatic leukaemia." 


CROTONLACTONES 

924 Fitzgerald, D. B., Belkin, M., Felix, M. D. 

and Carroll, K. TUMOR-DAMAGING CAPACITY 

OF PLANT MATERIALS. IV. CONIFERS. J. Nat. 


COOPERIA 

PENDUNCULATA 

925 

Taylor, A., Carmichael, N., McKenna, G. F. and 

Burlage, H. M. INHIBITION OF THE GROWTH OF 

EGG CULTIVATED TUMOR TISSUE BY EXTRACTS OF 

COOPERIA PEDUNCULATA HERB. Proc. Soc. Exp. 

Biol., H. Y., 1951, 77: 841-843. 8 refs. 

Abstracted in: ExcerpTa med., Sect. 5, 1952, 

5: No. 1556; Chem. Abstr., 1951, 45: 10358ÃŒ. 

930 

Pujman, Y DqleÃelovÃ¡.V. and Prokopova, S. 

VLIV NEKTERYCH LATER S PROTIRAKOVINNYM 

UCINKEM NA MYSI LEUKEMII. [THE INFLUENCE 

OF SOME SUBSTANCES WITH ANTICANCEROGENIC 

ACTION ON MICE LEUKEMIA.] Cesk. onkol., 

1955, 2: No. 1, 33-37. 13 refs. English 

summary". Alpha-beta-dichlorgamma-p-methoxyphenyl-delta-alpha-beta-crotonlacton 

and 

dimethansulfonester 1-4 butandiol had only 

slight influence on mouse, leukemia, while 

pentamethylenamide of bisethyleniminophosphoric 

acid in higher doses prolonged sur 

vival time, regulated the blood picture and 

decreased the size of the liver and the spleen.



56 

CROTONLACTONES 

(Continued) 

931 Semonsky, M., Ettel, V., Jelinek, V., ZikÃ¡n, V. 

and Pujman, 

RAKOVINY. 

V. 

1.0- 

POKUSY 0 CHEMOTHERAPII 

-p-METHOXYFENYL-A^- -2,3,4- 

TRIMETHOXYFENYL-Â« , IS -DICHLOR-^ ^, 0 - 

KROTONLAKTON. [CHEMOTHERAPY OF CANCER. 

?â€¢ -(p-METHOXYPHENYL)- AND -, -(2,3,4-TSI- 

I. 

METHOXYPHENYL)-Â«â€¢,/? -DICHLORO- A cL , 6 - 

CROTONLACTONE.] Cas. lek. cesk., 1954, 93: 

197-198. 

CTC 

3B:Fe 

932 Giudici, E. NOTA PRELIMINARE SULL'AZIONE ANTI 

CANCEROSA DELLA C.T.C. CON PARTICOLARE RIGUARDO 

ALLE FORME GINECOLOGICHE. [PRELIMINARY STUDY 

ON THE ANTI-CANCER EFFECT OF C.T.C., ESPECIAL 

LY CONCERNING GYNECOLOGICAL FORMS.] Neoplasie, 

Tor., 1952, 5: 80-101. 6 refs. Transcutaneous 

capillary chemotherapy (C.T.C.) is based on 

application of a medicated ointment called C.T.C. 

3 B:Fe(4.02% acetate; 2.50% Bi; S 1.80%; Mg 

0.60%; Ca 0.25%, stabilized with Na acetate) 

The ointment is placed on the skin as far re 

moved from the tumor and any of its mÃ©tastases 

as possible. Treatment is repeated daily. 

Six women with various gynecological tumors 

were healed. Gradual disappearance of the 

neoplastic tumefactions, cessation of hemorrhages 

and general improvement of the patients' over 

all condition resulted. 

CUCUMBER, 

SEA 

see HOLOTHURIN 

CYANATE 

933 

Beickert, A. and Siering, H. DIE WIRKUNG VON 

CYANAT UND THICCYANAT (RHODANID) AUF DAS 

MAUSEASCITESCARCINOM. 

NATE AND THIOCYANATE 

[THE ACTIONS OF CYA 

(RHODANID) ON THE AS- 

CITES 

1952, 

CANCER IN MICE.] Zschr. Krebsforsch., 

58: 614-620. 16 refs. Daily intraperitoÃ±eal 

injection of larger doses of 

cyanate caused slight tumor inhibition and 

no prolongation of life. Single injections 

of large doses resulted in increased mitotic 

activity. Thiocyanate had no therapeutic 

effect. 

934 Bernelli-Zazzera. A. CONTRIBUTO SPERIMENTALE 

ALLA INTERPRETÃ€ZIONE DELL'AZIONE ANTIMITOTICA 

DEL CIANATO DI SODIO. [AN EXPERIMENTAL CON 

TRIBUTION TO THE INTERPRETATION OF THE ANTI- 

MITCTIC ACTION OF SODIUM CYANATE.] Tumori, 

Milano, 1950, 24: 204-214. 32 refs. 

Abstracted in:~Excerpta med., Sect. 2, 1951, 

4: No. 2175. Sodium cyanate has no effect 

oh cutaneous cancer of mice. This study is 

essentially devoted to antimitotic effects 

of the agent on SH groups and proteolysis 

of papain. 

935 Bernelli-Zazzera, A. INTERFERENZE ENZIMATICHE 

DI SOSTANZE ANTIMITOTICHE. I. AZIONE DEL 

CIANATO E DELL'URETANO SULLA FOSFATASE ALCA 

LINE. [ENZYMATIC INTERFERENCE OF ANTIMITOTIC 

SUBSTANCES. I. EFFECT OF CYANATE AND URE- 

THANE ON ALKALINE PHOSPHATASE.] Tumori, Milano, 

1951, 37: 283-290. 18 reÃs. 

936 

Dean, R. F. A. and Gunz, F. W. ACTION OF CYA 

NATE ON THE BONE MARROW OF RATS. Nature, 

Lond., 1950, 165: 895-896. 6 refs. After 

injections of sodium cyanate into rats, there 

was first a slight depression of mitotic ac 

tivity in the bone marrow, then a considerable 

stimulation and finally another depression 

which was probably toxic in origin. It may 

be the effects on the bone marrow and blood 

are secondary to changes produced elsewhere 

in the body. 

837 

Rondoni, P. RECHERCHES SUR QUELQUES POISONS DE 

LA MITOSE. [RESEARCH ON CERTAIN UITOTIC POI 

SONS.] Acta UniÃ³ internat, 

1951, 7: 518-522. 20 refs. 

cancr., Louvain 

The action of 

sodium cyanate (NaCNO) on thÃ©enzyme system 

of LieberkÃ¼hn-Galeati cells of mouse intesti 

nal tissue and the effect of atabrin on chicken 

fibroblasts 

alterations 

in vitro were 

were "similar 

studied. 

to those 

The mitosis 

produced by 

colchicine." 

See 

373 792 

CYCLOHEXANE, 

HEXACHLORO- 

938 

Chaix, P. and Lacroix, L. ACTION DES /-ET S - 

HEXACHLOROCYCLOHEXANESSUR L'OEUF D'OURSIN 

AYANT ET APRES FÃ‰CONDATION. [THE ACTION 0F 

y - AND Ã• -HEXACHLOROCYCLOHEXANES ON THE EGGS 

OF THE SEA URCHIN BEFORE AND AFTER FERTILI 

ZATION.] 

2: 86-90. 

Biochim. 

6 refs. 

biophys. 

Abstracted 

acta, 

in: 

Amst., 

Chem. 

1948, 

Sbstr., 1948, 42: 6465a. 

CYRENS 

see STILBENES 

CYSTEINE 

939 

Black, M. M. SULFHYDRYL REDUCTION OF METHYLENE 

BLUE WITH REFERENCE TO ALTERATIONS IN MALIG 

NANT NEOPLASTIC DISEASE. Cancer Res., 1947, 

7: 592-594. Abstracted in: Chem. Abstr,, 

T948, 42: 6925e. 

940 

Weisberger, A. S., Suhrland, L. G.and Seifter, 

J. STUDIES ON ANALOGUES OF L-CYSTEINE AND 

L-CYSTINE. I. SOME STRUCTURAL REQUIREMENTS 

FOR INHIBITING THE INCORPORATION OF RADIO 

ACTIVE L-CYSTINE BY LEUKEMIC LEUKOCYTES. 

Blood, Bait., 1956, 11: 1-10. 15 refs. "Of 

the compounds studied and in the concentrations 

employed, only L-cysteine, selenium cystine 

and phenyl selenium cysteine were effective." 

941 

Koch, K. DIE WACHSTUMSBEEINFLUSSUNG DES 

TUMORASCITES DER MAUS DURCH CYSTEAMIN, 

CYSTAMIN UND CYSTEIN. [EFFECT ON 

CYSTEAMINE, CYSTAMINE AND CYSTEINE ON 

THE GROWTH OF MOUSE ASCITES TUMOR.] 

Arzneimitt. Forsch., 1955, 5: 625-626. 

Abstracted 

3646d. "Cysteamine 

in: Chem. 

furthers 

Abstr.7 

the 

1956, 

grÃw"th 

50: 

of Ehrlich ascites tumor; cystamine and 

cysteine have no effect." - Chem. Abstr. 

CYSTINE, 

SELENIUM 

942 

Weisberger, A. S. and Suhrland, L. G. STUDIES 

ON ANALOGUES OF L-CYSTEINE AND L-CYSTINE. 

III. THE EFFECT OF SELENIUM CYSTINE ON LEU 

KEMIA. Blood, Bait., 1956, U: 19-30. 

15 refs. "Selenium cystine was administered 

orally to 2 patients with acute leukemia and 

to 2 patients with chronic myeloid leukemia. 

In all patients there was a rapid decrease 

in the total leukocyte count as well as a 

decrease in spleen size." 

943 Weisberger, A. S. and Suhrland, L. G. STUDIES 

ON ANALOGUES OF L-CYSTEINE AND L-CYSTINE. 

II. THE EFFECT OF SELENIUM CYSTINE ON MURPHY 

LYMPHOSARCOMA TUMOR CELLS IN THE RAT. Blood, 

Bait., 1956, 11: 11-18. 13 refs. "Selenium 

cystine decreases the incorporation of S35 

L-cystine by rat Murphy lymphosarcoma tumor 

cells both in vitro and in vivo. Selenium 

cystine also decreases the growth of the tumor 

in the intact animal."



57 

CYSTINE, SELENIUM (Continued) 

See 

940 

CYTOCHROME 

C 

944 

GobÃ¢t, Y., Prader. A. and Regamey, J. AU SUJET 

DE L'ACTION DU CYTOCHROME C SUR L'ADENOCARCI- 

NOME DU SEIN (TUMEUR GREFFÃ‰E) CHEZ LA SOURIS. 

[THE ACTION OF CYTOCHROME C ON GRAFTED ADENO 

CARCINOMA OF THE BREAST IN MICE.] Oncologia, 

Basel, 1949, 2: 86-97. 44 refs. Mice with 

implants of mammary adenocarcinoma, which had 

been grafted one day or 17 days before treat 

ment, were injected intravenously, subcutaneously, 

or intratumorally with cytochrome C in 

doses of 0.025-2.5mg daily or at greater in 

tervals. The enzyme did not modify the de 

velopment of the tumors. 

See 

1829 

CYTOTOXIC COMPOUND (not named by author) 

945 

Zorn, B. ÃœBER DIE WIRKUNG EINES TUMORAUFLÃ–SEN 

DEN MITTELS. [EFFECTS OF A TUMOR DISSOLVING 

AGENT.] Naturwissenschaften, 1954, 41: 533- 

534. The author claims to have found~~a cytotoxic 

compound (not designated) which dissolves 

the protoplasm of tumor cells selectively with 

out destroying normal tissue. Experiments with 

the compound on Walker rat carcinoma and Jen 

sen sarcoma, Ehrlich mouse carcinoma, and 

spontaneous sarcoma and carcinoma in dogs are 

reported. 

DEHYDRASE, LACTIC ACID 

946 Vannotti, A. and Neukomm, S. SUR L'ACTION DE 

LA DÃŠHYDRASEDE L'ACIDE LACTIQUE SUR LA 

CROISSANCE DE L'ADENOCARCINOME MAMMAIREDE 

LA SOURIS. [THE EFFECT OF LACTIC ACID DE 

HYDRASE ON THE GROWTH OF MAMMARYADENOCARCI 

NOMA OF THE MOUSE.] Bull. Schweiz. Akad. 

roed. Wiss., 1950, 6: 130-133. 6 refs. 

DARAPRIM 

see PYRIMIDINES, 2, 4-DIAMINO- 

DEMECOLCEINAMINE 

see COLCHICINE, DESACETYLMETHYL â€”¿EFFECT 


DEMECOLCm 

see COLCHICINE, DESACETYLMETHYL - 

DEPA 

see PHOSPHORAMIDE, 

DIASONE 

DIETHYLENE- 

947 

Angelis, N. de. UN CASO DI HODGKIN A INIZIO 

SPINALE E LOCALIZZAZIONE VERTEBRALE PRECOCE 

TRATTATO CON DIASONE. [ONE CASE OF HODGKIN'S 

DISEASE OF A SPINAL BEGINNING AND VERTEBRAL 

LOCALIZATION TREATED WITH DIASONE] . Arch, 

ortop., Milano, 1946, 59: 183-192. 16 refs. 

1, 2, 5, 6-DIBENZANTHRACENE 

948 

Elson, L. A. and Haddow, A. 

OF 1:2:5:6-DIBENZANTHRACENE 

THE INHIBITORY 

ON THE GROWTH 

ACTION 

OF 

THE WALKER CARCINOMA 256 IN RATS MAINTAINED ON 

HIGH AND LOW PROTEIN DIETS. Brit. J. Cancer, 

1947, 1: 97-101. 8 reÃs. Abstracted in: Chem. 

Abstr., 1949, Â«: 306g. 

949 

Elson, L. A. and Harris, R. J. C. THE INFLUENCE 

OF 1:2:5:6-DIBENZANTHRACENE ON THE NUCLEIC 

ACID CONTENT OF THE LIVERS OF RATS MAINTAINED 

ON HIGH AND LOW-PROTEIN DIETS. Brit. J. Cancer, 


Chem. Xbstr., 1949, 43: 306d. 

950 

Haranghy, L., Gyergyay, F. and Antalffy, A. 

BEITRAGE ZU DER HEMMENDEN WIRKUNG DES 1-2-5- 

6-DIBENZANTHRAZENS AUF DAS KREBSWACHSTUM. 

[CANCER-GROWTH INHIBITING EFFECT OF 1:2:5:6- 

DIBENZANTHRACENE.] Acta morph. hung., 1953, 


Sed., Sect. 5, 1954, 7: No. 2822. Following 

one subcutaneous injecftion of 1.5 mg of 

1-2-5-6 dibenzanthracene into young male 

white rats, melanin-benzpyrine induced sar 

comas disappeared completely within 2 weeks. 

Tumor regression was most pronounced when 

compound was injected 27 days before tumor 

induction. 

DIGITALIS 

123 

DIOPTERIN 

see GLUTAMIC ACID, PTEROYLDI- 

DIPHOSPHOPYRIDINE NUCLEOTIDE 

951 

Wenner, E. C. E., Spirtes, M. A. and Weinhouse, 

S. ACTIVATION OF PYRUVATE OXIDATION IN TUMOR 

MITOCHONDRIA BY DIPHOSPHOPYRIDINE NUCLEOTIDE. 


421. 

DISACCHARIDES 

952 Cappelli, L. NUOVE POSSIBILITÃ€ PER LA CHEMIO 

TERAPIA ELETTIVA DEL CANCRO E DELLE MALATTIE 

DA INFEZIONE (I). [NEW POSSIBILITIES FOR 

ELECTIVE CHEMOTHERAPY FOR CANCER AND INFEC 

TIOUS DISEASES (I).] Policlinico, sez. prat., 

1947, 54: 789-795. 

DISODIUM FLUORENE 2, 7-DISULFONATE 

953 

Argus, M. F. STUDIES WITH A SQUAMOUS CELL STO 

MACH CARCINOMA OF THE MOUSE. Cancer Res., 

1935, Suppl. No. 2, 1-2. 

DIURETICS 

954 

Belkin, M., Fitzgerald, D. B. and Felix, II. D. 

TUMOR-DAMAGING CAPACITY OF PLANT MATERIALS. 

II. PLANTS USED AS DIURETICS. J. Nat. Cancer 

Inst., 1952, 13: 741-744. 44 refs. 

DOPAN 

see NITROGEN MUSTARDS. URACIL, 4-METHYL- 

5-DI (2-CHLOROETHYL) AMINO-



58 

DUAMIN 

see NITROGEN MUSTARDS 

ENZYMES, 

PROTEOLYTIC 

DULCITOL â€”¿ EFFECT 

See 

2977 

DYES 

see also under particular dye 


955 

Lewis, V. R. and Goland, P. P. IN VIVO STAIN 

ING AND RETARDATION OF TUMORS IN MICE. Anat. 

Reo., 1947, 99: 369-378. 4 reÃs. Naphthindone 

BB, ethyl violet, WIN-154 (Thiazine) Ahco 

26-47 (anthraquinone) AQD-241 (anthraquinone) 

stained and retarded tumor growth when fed 

to tumor-bearing mice. The structural fea 

tures common to these dyes are described. 

956 

Lewis, M. R., Goland, P. P. and Makler, J. THE 

TUMOR-INHIBITORY ACTIVITY OF DIARYL- AND TRI- 

ARYLMETHANE DYES. I. THE EHRLICH ASCI TES 

MOUSE TUMOR. Cancer Res., 1953, 13: 130-136. 

9 refs. 

957 

Lewis, M. R.. Goland, P. P. and Sloviter. H. A. 

SELECTIVE ACTION OF CERTAIN DYESTUFFS ON SAR 

COMATA AND CARCINOMATA. Anat. Ree., 1946, 

96: 201-220. 17 refs. "Two oxazine dyestuffs 

TKile blue and Cresyl violet), twelve xanthene 

dyestuffs (Acridine red, Rhodamine B, G, 

6G, 5GN and 6GN) and five acridine dyestuffs 

(Euchrysin 3RX, Brillant orange 3R, Acridine 

orange ES and Basic orange 3RN) stained trans 

planted sarcomata selectively and retarded 

their growth when administered to mice in 

their diet." 

958 R iley, J. F. RETARDATIONOF GROWTHOF A TRANS- 

PLANTABLECARCINOMAIN MICE FED BASIC META- 

CHROUATICDYES. Cancer Res., 1948, 8: 183- 

188. 34 refs. Abstracted in: Excerpta mod., 

Sect. 5, 1949, 2: No. 1405; Chem. Abstr., 

1949, 43: 1856ÃŒ. 

See 

3266 

E600 

see PHOSPHORIC ACID, DIETHYL p-NTTROPHENYL 

ESTER 

EMETINE 

959 

Isaka, H. THE EFFECT OF EMETINE HYDROCHLORIDE 

UPON THE YOSHIDA SARCOMA. Gann, Tokyo, 1950, 

Â«: 165-168. In English. 

See 

192 

ENZYME REACTORS 

961 

Gaschler, A. DIE PARENTERALE FERMENTHERAPIE 

MALIGNER TUMOREN UND CHRONISCHER ENTZÃœNDUNGS- 

ZUSTÃ„NDE. EIN BEITRAG ZUR GANZHEITSBEHAND 

LUNG DER GESCHWULSTKRANKHEITEN FÃœR BIOLOGEN 

UND Ã„RZTE. [PARENTERAL ENZYME THERAPY OF 

MALIGNANT TUMORS AND CHRONIC INFLAMMATIONS. 

A CONTRIBUTION TO SYSTEMIC TREATMENT OF NEO- 

PLASTIC 

CIANS.] 

DISEASES FOR BIOLOGISTS 

64 p. Ulm-Donau, Karl 

AND PHYSI 

F. Haug- 

Verlag, 1954, 

EPOXEDES 

962 Bullock, K. THE ANTICHOLINESTERASE ACTIVITY 

OF CERTAIN CYTOTOXIC SUBSTANCES. Chemistry 

& Industry, 1955, 36-38. 10 refs. 

963 Hendry, J. A., Homer, R. F., Rose, F, L. and 

Walpole, A. L. CYTOTOXIC AGENTS: I. BIS- 

EPOXIDES AND RELATED COMPOUNDS. Brit. J. 

Pharm., 1951, 6: 235-255. 7 refs. Abstracted 

in: Chem. Abstr., 1951, 45: 8656h. 

964 

Hendry, J. A., Homer, R. F., Rose, F. L. and 

Walpole, A. L. NEW CYTOTOXIC AGENTS WITH 

TUMOUR INHIBITORY ACTIVITY. II. BIS-EPOXIDES 

AND RELATED COMPOUNDS. 

cancr., Louvain, 1951, 

Acta UniÃ³ internat, 

7: 477-481. "A series 

of aliphatic, alicyclic and aromatic deriva 

tives carrying one, two, or three ethylene 

oxide residues has been examined against the 

Walker tumour for growth inhibitory activity 

and in many cases for specific cytotoxic 

action. Activity is limited to bis-functional 

derivatives.,â€žAlthough many of these compounds 

are active doses very near to the lethal have, 

in general 

effects." 

to be given to produce marked 

See 

1761 1971 

ERYTHROMYCIN 

See 

3353 

ETHANOL, 2- (2-CHLOROETHYLTfflO )- 

ETHANOL, 

2-CHLOROETHYL-2'-HYDROXY- 

see SULFIDE, 

ETHYL- 

2,2'-THIODL- 

965 Ramioul, H. and Crismer, R. UTILISATION D'UN 

DÃ‰RIVE D'HYDROLYSE DE L'YPÃ‰RITE. 'LE THIODI- 

GLYCOL' EN CANCÃ‰ROLOGIE. [USE OF A HYDROLYSIS 

DERIVATIVE OF NITROGEN-MUSTARD. 'THIODIGLYCOL' 

IN CANCER.] Acta clin, belg., 1952, 7: 45-64. 

8 refs. Thiodiglycol was given intravenously, 

intramuscularly and subcutaneously to 24 patients 

with various incurable malignant tumors, alone or 

in combination with x-ray, radium and nitrogen 

mustard. Four patients with epithelioma showed 

improved general condition. There was a de 

crease of the size of the tumor in some cases. 

960 

Lebrun, J. and Delaunay, A. RECHERCHES SUR LE 

TACTISME LEUCOCYTAIRE; ACTION, SUR CE PHÃ‰NOMÃˆNE, 

DE DIFFERENTS EFFECTEURS D'ENZYMES. [INVESTI 

GATION ON LEUCOCYTIC CHEMOTAXIS; EFFECT ON THIS 

PHENOMENONOF DIFFERENT ENZYME REACTORS.] 

Ann. Inst. Pasteur, Par., 1951, 80: 524-535. 

Abstracted in: Chem. Abstr., 1952746: 8682h. 

ETHER DERIVATIVES, 

See 

246 

BENZYL-



59 

ETHER VAPORS â€”¿EFFECT ON TUMOR GROWTH 

966 

Meyer, J. R. EFEITO DA INALAÃ‡AODE VAPORES DE 

Ã‰TERNO DESENVOLVIMENTO DO ADENOCARCIN OHA 

TRANSPLANTAVEL DO CAMONDONGO. [THE EFFECT OF 

INHALATION OF ETHER VAPORS ON THE DEVELOPMENT 

OF TRANSPLANTABLE ADENOCARCINOMA OF RAT.] 

Arq. Inst. biol., S. Paulo, 1950-51, 20: 

205-207. pi. 5 refs. English summary. 

THERAPY 

967 Lackner, J. ERFAHRUNGEN MIT DER WARM-AETHER- 

INHALATION BEI KARZINOMKRANKEN. [CLINICAL 

RESULTS WITH WARM ETHER INHALATION IN CASES 

OF CARCINOMA.] Strahlentherapie, 1953, 91: 

544-550. 3 refs. English summary. "The 

author studied the reaction of 27 carcinoma 

patients to the treatment recommended by 

Tiegel..Â»According to its theoretical basis 

and our practical experiences, this treat 

ment is not capable of healing cancer." 

968 

Tiegel, M. DIE BEDEUTUNG DER QUANTENBIOLOGIE 

FÃœR DIE BEHANDLUNG VON TUBERKULOSE, SEPTISCHEN 

INFEKTIONEN UND MALIGNEN TUMOREN MIT INHALATION 

VON ÃœBERHITZTEM AETHERDAMPF. [THE SIGNIFICANCE 

OF QUANTUM BIOLOGY IN THE TREATMENT OF TUBER 

CULOSIS, SEPTIC INFECTIONS AND MALIGNANT TUMORS 

WITH INHALATION OF OVERHEATED ETHER VAPORS.] 

Ars medici, Basel, 1950, 40: 39-46. 9 refs. 

969 

Tiegel, M. GEDANKEN ZUM KREBSPROBLEM; VORLÃ„UFIGE 

MITTEILUNG ÃœBER THERAPEUTISCHE ERGEBNISSE BEI 

INHALATION VON ÃœBERHITZTEM AETHERDAMPF. 

[THOUGHTS ON THE PROBLEM OF CANCER; PRELIMINARY 

REPORT ON THE THERAPEUTIC RESULTS FOLLOWING IN 

HALATION OF SUPERHEATED ETHER VAPORS.] Ars 

medici, Basel, 1948, 38: 607-618. 21 refs. 

Review of the literature, mode of action of 

ether inhalation and 7 case histories are re 

ported. General improvement in the condition 

of patients as well as tumor regression was 

found. 

970 

Tiegel, M. WEITERE ANREGUNGEN ZUM KREBSPROBLEU: 

MITTEILUNG ÃœBER EINE SELBSBEOBACHTUNG. [FUR 

THER ENCOURAGEMENT IN THE PROBLEM OF CANCER: 

REPORT OF AN OBSERVATION 

Ars medici, Basel, 1949, 

IN MY OWN CASE.] 

39: 166-176. 13 refs. 

85 

ETHIONINE 

971 

Alvizouri, M. and Warren S. EFFECTS OF DL- 

ETHIONINE ON THE PANCREAS AND OTHER ORGANS. 

A. IÂ«.A. Arch. Path., Chic., 1954, 57_: 

130-137. 9 refs. DL-ethionine caused 

extensive necrosis of the pancreas and 

degenerative changes in the testicle, kidney 

and liver of rats. No clinical or histological 

difference was observed between 

treated and untreated tumour-bearing rats. 

972 Gualandl, G. and Bergamini, A. L'ETHIONINE 

DANS LE TRAITEMENT DU CANCER DU PANCRÃ‰AS: 

PREMIER ESSAI. [ETHIONINE IN THE TREATMENT 

OF CANCER OF THE PANCREAS: FIRST TRIAL.] 

Arch. mal. app. digest., Par., 1954, 43: 

305-310. 18 refs. 

973 

Levy, H. M., Hontanez, G., Murphy, E. A. and 

DÃ¼nn, U. S. EFFECT OF ETHIONINE ON TUMOR 

GROWTH AND LIVER AMINO AC TDS IN RATS. 


Abstracted in: ChemT~Abstr., 1953, 47: 

11482Ã•. 

974 Levy, H. M., Murphy, E. A. and Dunn, M. S. 

EFFECT OF ETHIONINE ON THE FREE AMINO ACIDS 

IN LIVER OF TUMOROUS AND NONTUMOROUS RATS. 


975 White, L. P. and Shimkin, M. B. EFFECTS OF DL- 

ETHIONINE IN SIX PATIENTS WITH NEOPLASTIC 

DISEASE. Cancer, Phila., 1954, 7: 867-672. 

22 refs. 

See 

1348 

ETHYL ALCOHOL 

976 Bass, A. D. and Freeman, M. L. H. REGRESSION 

OF LYMPHOSARCOMA PRODUCED BY INTRAPERITONEAL 

ADMINISTRATION OF 95% ETHYL ALCOHOL. Science, 


Biol. A~oÂ¥tr.,Bait., 1948, 22: No. 18401. 

See 

1055 

ETHYLAMINE, 

0-MERCAPTO- 

977 

Bacq, Z. M. and Ramioul, H. ACTION FAVORABLE 

DE LA & -MERCAPTO-ETHYLAMINE DANS CERTAINS CAS 

DE LEUCEMIE CHRONIQUE. [FAVORABLE ACTION OF 

/3-MERCAPTO-ETHYLAMINE IN CERTAIN CASES OF 

CHRONIC LEUKEMIA.] Rev. mÃ©d. LiÃ¨ge, 1953, 


mea., Sect. 16, 1954, No. 222. 

978 

Bacq, Z. M., Bernard, J., Ramioul, H. and 

Deltour, G. LA MERCAPTO-ETHYLAMINE DANS LE 

TRAITEMENT DES LEUCEMIES CHRONIQUES. [TREAT 

MENT OF CHRONIC LEUKEMIA WITH MERCAPTO-ETHYL- 

AMINK.,] Bull. Acad. med. Belgique, 6. sÃ©r., 

1952, 17: 460-484. Discussion: p. 483-484. 

11 refs~7 Abstracted in: Leukemia Abstr., 

1953, 1: No. 131. 

979 

ChÃ¨vremont, S. and Chevremont, M. ACTION DE 

LAj3 -MERCAPTOÃ‰THYLAMINESUR LA CROISSANCE 

ET LA MITOSE EN CULTURE DE TISSUS. [EFFECT 

OF /9 -MERCAPTOETHYLAMINE ON GROWTH AND MITO 

SIS IN TISSUE CULTURES.] C. rend. Soc. biol., 


ExcerpÃ®Ã¢~med., Sect. 16, 1954, 2: No. 4788; 

Chem. Abstr., 1954, 48: 275e. 

980 

Gennes, L. de, Deltour, G., Tourneur, R. and 

Leprat, J. TRAITEMENT D'UN CAS DE LYMPHO- 

SARCOMATOSE PAR LA /3-MERCAPTOETHYLAMINE. 

[TREATMENT OF A CASE OF LYMPHOSARCOMATOSIS 

BY /S-MERCAPTOETHYLAMINE.] Bull. Soc. mÃªd. 

hÃ¡p. Paris, 1953, 69: 108-113. 13 refs. 

Abstracted in: Index analyt. cancer., Par., 

1954, 25: No. 1017. 

98Manil, P. ACTION DE LA /ÃŒ-MERCAPTOÃ‰THYLAMINE 

SUR LE CROWN-GALL. IN VIVO, ET SUR LA LEVURE. 

[EFFECT OF BETA-MERCAPTOETHYLAMINE ON CROWN 

GALL,IN VIVO AND ON YEAST.] C. rend. Soc. 

biol., 1954, 148: 406-408. 2 refs. 

ETHYLAMINES, a, (3-DIPHENYL- 

982 Leiter, J., Perrault, A., Hartwell, J. L., Kline, 

I and Shear, M. J. NEGATIVE RESULTS WITH 

DIPHENYLETHYLAMINES IN PRODUCING DAMAGE IN 

SARCOMA 37. Cancer Res., 1955, Suppl. No. 2, 

109-123.



60 

ETHYLAMINES, a, /3-DIPHENYL- (Continued) 

983 

LettrÃ©, H., Hex, A. and Ruhbaum, E. VERGLEICH 

HOMOLOGER 4'-ALKOXYSTILBYLAMINE UND OPTISCHER 

ANTIPCÂ»EN AUF IHRE ZELLTEILUNGSHEMMENDE 

WIRKUNG. [COyPARISON OF THE ANTI-MITOTIC 

EFFECT OF HOMOLOGOUS 4'-ALKOXY-STILBYLAMINES 

AND THEIR OPTICAL ANTIPODES.] Hoppe Seyler 

Zschr., 1952, 289: 119-123. 

984 

LettrÃ©, H. WEITERE UNTERSUCHUNGEN ZUR MITOSE- 

GIFTWIRKUNG VON STILBYLAMINDERIVATEN. [FUR 

THER STUDIES ON THE ACTIVITY OF STILBYLAMINE 

DERIVATIVES AS MITOTIC POISONS.] Hoppe Seyler 

Zschr., 1952, 289! 220-225. 10 refs. Ab 

stracted in: CEern. Abstr., 1954, 48: 10920c. 

985 

LettrÃ©, H., LettrÃ©, R. and Pflanz, C. ÃœBERSY 

NERGISTEN VON 1IITOSEGIFTEN. [SYNERGISTS OF 

MITOTIC POISONS.] Naturwissenschaften, 1950, 

37: 563. 6 refs. Abstracted in: Chora. Abstr., 

ISSI, 45: 9577h. 

986 Owari, S. EFFECT OF



61 

FICUS CARICA L. 

LATEX (Continued) 

997 

Ullman, S. B., Clark, G. M. and Roan, K. M. 

THE EFFECTS OF THE FRACTION R3 OF THE LATEX 

OF FICUS CARICA L. ON THE TISSUES OF MICE 

BEARING SPONTANEOUS MAMMARY TUMORS. Exp. 

M. & S., Basel, 1952, 10: 287-305. 16 refs. 

Abstracted in: Excerpta med., Sect. 16, 

1954, 2: No. 122. 

FLAVONOIDS 

398 

Sokoloff, B., Eddy, W. H. and CÃńe, G. EFFECT 

OF BIOFLAVONOIDS ON RADIOSENSITIVITY OF TRANS 

PLANTED TUMORS; EFFECT ON TOLERANCE TO CON 

TACT RADIATION. A.M.A. Arch. Path., 1952, 

54: 197-203. Approx. 16 refs. Abstracted in: 


Â»99 Sokoloff, B., Eddy, W. H. and Redd, J. B. 

FLAVONOIDS IN EXPERIMENTAL CANCERS. AMA 

Arch. Path., 1951, 52: 215-220. 

A flavonoid compouno~similar to 

13 refs. 

the original 

vitamin P of Szent-Gyorgyi given subcutaneous 

ly to "rat bearers of Carcinoma 175-G and 

Crocker Rat Carcinoma and to mice bearers of 

Sarcoma 180 in a total dose of 40, 100, and 

200 mg/100 gm body wt, respectively, pro 

duced a moderate inhibitory effect on tumor 

growth. The flavonoid compound administered 

in these doses to normal animals had no toxic 

effect. The flavonoid compound given to 

adrenalectomized rats in a daily dose of 

5 mg/100 gm wt. prolonged their life span." 

FLAVOTINE 

FLUORENE 

6-CHLORO-9- 

see ISOALLOXAZINE, 

SORBIT YL)- 

(I'-D- 

1001 

Black, M. M., Kleiner, I. S. and Speer, f. D. 

EFFECTS OF ENZYME INHIBITORS ON IN VITRO 

DEHYDROGENASE ACTIVITY OF CANCER TISSUE 

SLICES. Proc. Soc. Exp. Biol., N. Y., 


1951, 


Chem. Abstr., 1951, 45: No. 96S4f. 

1002 

Finerty, J. C. and Grace, J. D. EFFECT OF 

FLUORIDE ON TUMOR GROWTH. Texas 

M., 1952, 1Â£: 501-503. 3 refs. 

Rep. Biol. 

Implants 

of Walker rat sarcoma 319 in rats receiving 

various amounts of potassium fluoride in 

their drinking water were neither inhibited 

nor stimulated. 

FLUORINE 

COMPOUNDS 

1003 

Sellei, C., Olah, G., Eckhardt, S. and KapÃ¡s, L. 

SZERVES FLUORVEGYÃœLETEK HATÃ•SA A KISÃ‰RLETES 

DAGANATOKRA. [THE EFFECT OF ORGANIC FLUORINE 

COMPOUNDS ON EXPERIMENTAL TUMORS.] Orv. 

hetil., 1952, 93: 756. Mono-fluorine, p- 

fluorphenyl, mono-fluorbenzole and diisopropyl 

fluorophosphate were tested for their chemotherapeutic 

value on Ehrlich mouse carcinoma 

and GuÃ©rin rat tumor. Generally, all the 

compounds were very toxic, but in some in 

stances slight tumor regression was observed 

if the animal survived. 

1004 

Sellei, C., OlÃ¡h, G., Eckhardt, S. and KapÃ¡s, 

L. WIRKUNG ORGANISCHER FLUORVERBINDUNGEN 

AUF EXPERIMENTELL ERZEUGTE GESCHWÃœLSTE. 

[THE EFFECT OF ORGANIC FLUORINE COMPOUNDS 

ON EXPERIMENTALLY INDUCED NEOPLASMS.] Arch. 

GeschwUlstforsch., 1953, 5: 263-264. 

Abstracted in: Excerpta med., Sect. 16, 1954 

2: No. 583. 

254 

FOLACLN 

see 

FOLIC ACID 

FLUORENE, 

Sea 

225 

FOLIC ACID â€”¿ EFFECT 


1005 

EFFECTS OF ANTIMETABOLITESOF FOLACIN ON CELL 

DIVISION. Nutrit. Rev., 1954, 12; 250-2. 

A brief review. 

FLUORENE-2, 

See 

953 

FLUORE SCEIN 

See 

1691 

FLUORIDE 

1, 2, 5, 6-DIBENZO- 

7-DISULFONAMIDO-2'-PYRIDINE- 

1000 

Black, M. M., Kleiner, I. S., and Bolker, H 

GLYCOLYTIC ENZYME INHIBITOR THERAPY IN HUMAN 

MALIGNANT 

314-319. 

NEOPLASM. 

5 refs. 

Cancer Res., 1949, 9- 

EFFECT 


1006 

LettrÃ©, H. and Landschutz, C. ZUR WIRKUNG DER 

FOLINSAURE AUF DIE KREBSZELLE. [ACTION OF 

FOLIC ACID ON THE CANCER CELL.] Naturwissen 

schaften, 1947, 34: 345-346. 7 refs. Abstrac 

ted in: CheÂ». AbiTr., 1951, 45: 245a. "In a 

concentration of 75 per ce folie acid causes 

no inhibition of mitosis in chicken heart 

fibroblasts. Injection of 4 mg folie acid 

into mouse ascites tumor causes, after 15 

hours, a 50% increase in pathological metaphases. 

nounced 

Continued injections bring on pro 

chromatin damage of all tumor cells." 


1007 

Leuchtenberger, C. CHEMOTHERAPEUTIC REGRESSIONS 

OF TRANSPLANTED AND SPONTANEOUS CANCERS IN 

MICE. 

NEOUS 

III. 

TUMORS 

RESULTS OF TREATMENT OF SPONTA 

WITH "FOLIC ACID" AND ALLIED 

SUBSTANCES. In: APPROACHES TO TUMOR CHEMO 

THERAPY. WasBT, Am. 

p. 157-162. 4 refs. 

Ass. Advance. Sc., 1947,



62 

FOLIC ACID â€”¿ EFFECT 

(Continued) 


1008 

Leuchtenberger, R. CHEMOTHERAPEUTIC REGRESSIONS 

OF TRANSPLANTED AND SPONTANEOUS CANCERS IN 

MICE. IV. HISTOLOGICAL CHANGES OCCURRING IN 

BREAST CANCERS OF MICE TREATED WITH FOLIC ACID. 

In: APPROACHES TO TUMOR CHEMOTHERAPY. Wash., 

AÃ¯. Ass. Advance. Sc., 1947, p. 163-207. 

Discussion: p. 195-207. 

1009 

Lewisohn, R., Leuchtenberger, C., Leuchtenberger, 

R. and Keresztesy, J. C. THE INFLUENCE OF 

LIVER L. CASEI FACTOR ON SPONTANEOUS BREAST 

CANCER IN MICE. Science, 1946, 104: 436-437. 

3 reÃs. Abstracted in: Chen. Absir"., 1947, 

41: 1319e. 

1370 1690 1775 

SeÂ« 

SYNERGISTIC 

3500 

THERAPY 

ACTION 

1010 

Clement, R.j Gerbeaux, J. and Nebout, R. LEU 

COSES AIGUÃ‹S ET ACIDE FOLIQUE. [COLIC ACID 

AND ACUTE LEUKEMIA.] Arch. fr. pediat., 

1948, 5: 273-274. Folie acid caused at each 

application a rapid clinical improvement and 

a modification of the blood picture. 

1011 

Rohde, G. DIE BEKÃ„MPFUNG DES KREBSES DURCH 

VITAMIN M (FOLIC ACID). [CANCER TREATMENT 

WITH 

1949, 

VITAMIN M (FOLIC ACID).] 

4: 949-950. 

Deut. Gesundhwes., 

See 

1665 

FOLIC ACID ANALOGS 

1012 

Dewey, V. C., Kidder, G. W. and Parks, R. Â£., Jr. 

GROWTH INHIBITION IN TETRAHYMENA BY FOLIC ACID 

ANALOGS. Proc. Soc. Exp. Biol., N. Y., 1951, 

78: 91-95. 11 refs. "The inhibition produced 

By A-ninopterin is strictly competitive, being 

released over wide ranges of concentration of 

folie 

other 

acid. The inhibition indices of the 

two analogs [A-methopterin and A-denopterin] 

decrease as the amount of folie acid 

in the medium increases until a certain level 

is reached, at which they become constant. 

This shifting index is tentatively explained 

on the basis of the ability 

deaminate the 4-position of 

of Tetrahymena 

the analogs." 

to 

1013 

Taylor, A. and Carmichael, N. FOLIC ACID ANA 

LOGS AND THE 

Cancer Res., 

GROWTH OF 

1951. 11: 

EMBRYO AND TUMOR TISSUE. 

519-522. 15 refs. 

Tumor growth was inHTbited: 50, 73 and 83% 

by teropterin in doses of 1.0, 0.5 and 0.1 mg 

per injection; 67 and 12% by aminopterin in 

doses of 0.15 and 0.1 mg; 56% by An-Fol-A at 

1.0 mg per injection. Aminopterin inhibited 

the growth of chick embryo as well as of the 

tumor. Folie acid and folinic acid alone and 

in combination with teropterin and aminopterin 

slightly inhibited tumor and embryo growth 

when each of these compounds was given in 

0.1 mg doses. 

See 

2649 

FOLIC ACID ANTAGONISTS â€”¿ EFFECT ON MALIGNANT 

GROWTH 

1014 

Cutting, W. C., Dreisbach, R. H., Neff, B. J., 

Tiffany, V. P. and Tripi. H. B. CANCER CHEMO 

THERAPY. 

Stanford 

I. TRIALS WITH ANTIVIRAL AGENTS. 

. Bull., 1949, 7: 161-164. 6 refs. 

1015 

Haenel, U CYTOLOGIC STUDIES ON THE EFFECT OF 

FOLIC ACID ANTAGONISTS ON LEUKEMIC AND BLOOD- 

FORMING CELLS. Proc. Congr. Internat. Soc. 

Hemat., (1950) 1951, 3. meet., 331-336. 3 pi. 

14 refs. 

1016 

Jukes, T. H., Franklin, A. L. and Stokstad, 

E. L. R. PTEROYLGLUTAMIC ACID ANTAGONISTS. 

Ann. N. York Acad. Sc., 1950, 52: 1336-1341. 

47 refs. A review. 

1017 

Osteux, R, LES 'ANTAGONISTES' EN CHIMIOTHÃ‰RA 

PIE ANTI-CANCÃ‰REUSE. ['ANTAGONISTS' IN THE 

CHEMOTHERAPY OF CANCER.] CancÃ©rologie, Lille, 

1953, 1.: 15-18. 

1018 

Ruffo, A. L'INIBIZIONE COMPETITIVA IN CHEMIO 

TERAPIA E NUOVE SOSTANZE AD AZIONE CANCERO- 

LITICA. [COMPETITIVE INHIBITION IN CHEMOTHERA 

PY AND NEÂ»SUBSTANCES WITH CANCEROLYTIC ACTION.! 

Minerva med., Tor., 1949, 40: pt. 1, 625-628. 

19 refs. Abstracted in: CKern. Abstr., 1949 

43: 7586h. 

1019 

Smith, J. M., Jr. FOLIC ACID ANTAGONISTS. 

N. Jersey J. Pharm., 1949, 22: 15-20. 

42 refs. 

1020 

Â«Weir, D. R., Welch, A. D. and Heinle, R. W. 

EFFECT OF AN ANTAGONIST OF PTEROYLGLUTAMIC 

ACID ON THE LEUKEMIA OF AK MICE. Proc. Soc. 

Exp. Biol., N. Y., 1949, 71: 107-111. Ab 

stracted in: Chem. Abstr .'^"1949, 43: 6733ÃŒ. 

"The antagonist was a crude synthÃªTic pre 

paration presumably containing 7-methyland 

9-methylpteroylglutamic acids. The 

transplanted leukemia of Ak mice can be 

partially controlled either by a pteroylglutamic 

acid-free diet containing succinylsulfathiazole 

and the crude antagonist, or 

by addition of large amounts of the anta 

gonist to an unpurified stock diet." -Chem. 

Abstr. 


1021 

Hertz, R. INTERFERENCE WITH ESTROGEN-INDUCED 

TISSUE GROWTH IN THE CHICK GENITAL TRACT BY 

A 

300. 

FOLIC 

8 

ACID 

refs. 

ANTAGONIST. 

Abstracted 

Science, 

in: Chem. 

1948, 

AbstrTT" 

107: 

1948, 42: 4659a. 

1022 

Hertz, R. and Tullner, W. W. QUANTITATIVE INTER 

FERENCE WITH ESTROGEN-INDUCED TISSUE GROWTH 

BY FOLIC ACID ANTAGONISTS. Endocrinology, 1949, 

44; 278-282. 8 refs. Abstracted in: Chem. 

Abstr., 1949, 43: 8491c. 

1023 

Messerschmitt, J. LES ANTAGONISTES DE L'ACIDE 

PTEROYLGLUTAMIQUE (ACIDE FOLIQUE). [PTEROYL 

GLUTAMIC ACID ANTAGONISTS (FOLIC ACID).] 

Rev. hÃ©mat., Par., 1949, 4: 194-245. 123 reÃs. 

An extensive review, treating of the structure 

and biological action of folio acid antagonists. 

See 

1947 2649



63 

FOLIC ACID ANTAGONISTS â€”¿ EFFECT 

GROWTH IN PLANTS 

ON TUMOR 

1024 

De Hopp, R. S. THE EXPERIMENTAL INHIBITION OF 

THE GROWTH OF PLANT TUMORS. 

Symposia Biol., 1953, No. 6, 

Brookhaven 

128-136. Dis 

cussion: p. 135-136. 7 refs. 

1025 

De Hopp, R. S. INHIBITING ACTION OF SOMEANA 

LOGUES 

TUMORS. 

OF 

Nature, 

FOLIC ACID 

Lond., 

ON THE 

1949, 

GROWTHOF 

164: -954. 

PLANT 


0M 

1370 

EFFECTS, COUNTERACTION TO 

1026 

JimÃ©nez de Asua, F. QUELQUESCONSIDÃ‰RATIONS 

SUR LE TRAITEMENTDES LEUCEMIES AIGUÃ‹S, AVEC 

UNE ETUDE PARTICULIERE SUR L'ACTION DU CITRO- 

VORUMFACTEUR(LEUCOVORINE). [SOME CONSIDERA 

TIONS IN THE TREATMENTOF ACUTELEUKEMIAWITH 

A SPECIAL STUDYON THE ACTION OF THE CITRO- 

VORUMFACTOR(LEUCOVORINE).] Sang, Par., 

1953, 24: 592-599. Leucovorine has no therapeutic~Ã«~f 

f ect on leukemia but toxic effects 

of antifolic drugs used therapeutically were 

aleviated by the citrovorum factor, without 

interfering with the anti-leukemic action of 

the drugs. Leucovorine was observed to have 

no effect on antifolic drug resistance. 

1027 Skipper, H. E., Bell, M. and Chapman, J. B. 

PARTIAL REVERSALOF THE ANTILEUKEMICACTION 

OF FOLIC ACID ANTAGONISTSBY NEUCLEIC ACIDS 


METABOLISM (INCLUDING EFFECTS ON 

METABOLIC PROCESSES) 

1028 

Rogers, L. L. and Shive, W. BIOCHEMICAL TRANS 

FORMATIONS AS DETERMINED BY COMPETITIVE ANA 

LOGUE-METABOLITE GROWTH INHIBITIONS; RELA 

TIONSHIP OF PURINES AND THYMINE TO FOLIC ACID. 

J. Biol. Chem., 1948, 172: 751-758. 17 refs. 

1029 oolley, D. W. and Pringle, A. SOME STRUCTURAL 

ANALOGUES ANTAGONISTIC TO PTEROYLGLUTAMIC 

ACID. J. Biol. Chem., 1948, 174: 327-333. 

13 refs. 

MODE 

OF ACTION 

1030 

Mentzer, C. and Meunier, P. COMMENT APPLIQUER 

LA NOTION D'ANALOGIE STRUCTURALE AU PROBLEME 

DE LA THÃ‰RAPEUTIQUE DES CANCERS. [APPLICA 

TION OF THE CONCEPTION OF STRUCTURAL ANALOGY 

TO THE PROBLEM 

Par., 1950, 5: 

OF CANCER 

192-198. 

THERAPY.] 

13 refs. 

ThÃ©rapie, 

1862 

RESISTANCE TO 

1031 Law, L. W. MECHANISMS OF RESISTANCE AND DEPEN 

DENCE IN GROWTH OF LEUKEHIC CELLS. 

Rep. Biol. M., 1952, 10: 571-597. 

Texas 

46 refs. 

The folie acid antagonists and 8-azaguanine 

were used in this study on the development 

of resistance and dependence in leukemic 

cells. 

1032 

Law, L. 

CELLS 

W. 

TO 

ORIGIN OF 

FOLIC ACID 

THE RESISTANCE OF LEUKAEMIC 

ANTAGONISTS. Nature, Lond., 

1952, 169: 628-629. 

Excerpta~~med., Sect. 

9 refs. 

2, 1853, 


6: No. 2024. 

2687 

THERAPY 

1033 

Astaldi. G. and Mauri, C. RECHERCHES SUR L'AC 

TIVITE PROLIFERAI!VE DE L'HEMOCYTOBLASTE DE 

LA LEUCÃ‰MIE AIGUÃ‹. [INVESTIGATIONS ON THE 

PROLIFERATIVE ACTIVITY OF LEUKEMIC HEMOCYTO- 

BLASTS.] Rev. beige path., 1953, 23: 69-82. 


1034 

Burchenal, J. H. FOLIC ACID ANTAGONISTS. Am. 

J. Clin. Nutrit., 1955, 3: 311-320. 115 

refs. 

1035 Conte Maretta, R. GLI "ANTAGONISTI" DELL'ACIDO 

FOLICO NELLA CURA DELLE 

"AMINOPTERINA." [FOLIC 

LEUCEMIE. USO DELL '- 

ACID ANTAGONISTS IN 

THE TREATMENT OF THE LEUKEMIAS. USE OF AMINO- 

PTERIN.] Progr. med., Nap., 1949, 5: 457-462. 


1036 

Cotton, C. M. CANCER CONQUEST SEARCH; SETS 

LEUKEMIA RECORD. Science News Lett., 1954, 

65J 211. 

1037 

Farber, S. SOME OBSERVATIONS ON THE EFFECT OF 

FOLIC ACID ANTAGONISTS ON ACUTE LEUKEMIA AND 

OTHER FORMS OF INCURABLE CANCER. Blood, Bait., 

1949, 4: 160-167. Abstracted in: Excerpta med., 

Sect. 2, 1949, 2: No. 6138. 

1038 

Â»McLean, J. A. TREATMENT OF ACUTE LEUCAEMIA BY 

FOLIC 

1951, 

ACID ANTAGONISTS. 

2: 119-121. 

Med. J. Australia, 

1039 

Matoth, Y. FOLIC ACID ANTAGONISTS IN THE TREAT 

MENT OF ACUTE LEUKAEMIA. Harefuah, Tel-Aviv, 

1950, 39: 150-154. 16 refs. 

EnglisIT~summary. Abstracted 

In Hebrew. 


Sect. 2, 1951, 4: No. 6848. 

1040 

Paolino, W. GLI ANTAGONISTI DELL'ACIDO FOLICO 

NEL TRATTAMENTO DELLE LEUCEMIE E DEI TUMORI. 

IL PROBLEMA DELLA RESISTENZA ED I RAPPORTI 

CON IL CITROVORUM FACTOR. [FOLIC ACID ANTA 

GONISTS IN THERAPY OF LEUKEMIA AND TUMORS; 

CITROVORUM FACTOR.] 

43: pt. 2, 1296-1300. 

Minerva med., Tor., 1952, 

1041 

Sacks, M. S. THE PRESENT STATUS OF THERAPY IN 

ACUTE LEUKEMIA. Ann. Int. M., 1952, 37: 400- 

403. An editorial. 19 refs. 

1042 

Silverman, F. N. TREATMENT OF LEUKEMIA AND 

ALLIED DISORDERS WITH FOLIC ACID ANTAGONISTS; 

EFFECT OF AMINOPTERIN ON SKELETAL LESIONS. 

Radiology, 1950, 54: 665-678. Spanish trans 

lation: p. 677-678T Abstracted in: Chem. 

Abstr., 1950, 44: 10142Ã•. A review. 

1043 

Â«Sojo, E. T. EL USO DE SUBSTANCIAS ANTAGONISTAS 

DEL Ã€CIDO FOLICO EN EL TRATAMIENTO DE LAS 

LEUCOSIS AGUDAS. [FOLIC ACID ANTAGONISTS IN 

ACUTE LEUKEMIAS.] Arch, argent, pediat., 

1949, 32: 200-203. 

1044 

Â«Stickney, J. M., Mills, S. D., Hagedorn, A. B. 

and Cooper, T. THE TREATMENT OF ACUTE LEU 

KEMIA WITH FOLIC ACID 

Mayo Clin., 1949, 24: 

ANTAGONISTS. 

525-533. 

Proc.



64 

FOLIC ACID ANTAGONISTS â€”¿ THERAPY 

(Continued) 

1045 

Wilson, S. J. PLATELET REGENERATION DURING THERAPY 

OF ACUTE LEUKEMIA WITH FOLIC ACID ANTAGONISTS. 

Proc. Soc. Exp. Biol., N. Y., 1950, 73: 620-622. 

1046 

Wolman, I. J., Githens, J. H., Dickstein, B., 

Eglick, P. G., Slaughter, B. C., Butson, 

H. E. and Evans, A. N. THE FOLIC ACID 

ANTAGONISTS IN ACUTE LEUKEMIA OF CHILDHOOD. 

Q. Rev. Pediat., 1952, 7: 121-138. 17 refs. 

1047 Â»right, J. C., Prigot, A., Â»right, B. P., 

Weintraub, S. and Â»right, L. T. AN EVALUA 

TION OF FOLIC ACID ANTAGONISTS IN ADULTS WITH 

NEOPLASTIC DISEASES: A STUDY OF 93 PATIENTS 

WITH INCURABLE NEOPLASMS. J. Nat. M. Ass., 

1951, 43: 211-240. 80 refs. 

1048 

Wright, L.T., Prigot, A., Wright, B. P., Wright, 

J. C. and Hjelt, I. CHEMOTHERAPY OF LEUKE 

MIA IN ADULTS. Harlem Hosp. Bull., N. Y., 

1951-1952, 4: 91-113. 

See 

595 

3401 

1052 1089 1261 2017 

FOLIC ACID DEFICIENCY â€”¿ EFFECT ON GROWTH 

1049 

Â»oll, E. EFFECTS OF FOLIC ACID DEFICIENCY AND 

A FOLIC ACID ANTAGONIST ON CHICKS. Arch. Path. 

Chic., 1948, 46: 559-566. 9 refs. 

1050 

Woll, E., Dornbush, A. C. and Little, P. A. 

ROUS SARCOMA IN FOLIC ACID-DEFICIENT CHICKS. 

MORPHOLOGY AND BIOASSAY. Cancer Res., 1951, 

11: 788-790. pi. 7 refs. Abstracted in: 

C"n~em.Abstr., 1952, 46: 4079c. 

FOLIC ACIDS 

1051 Burchenal, J. H., Johnston, S. F., Burchenal, 

J. R., Kushida, M. N., Robinson, E. and 

Stock, C. C. CHEMOTHERAPY OF LEUKEMIA. 

IV. EFFECT OF FOLIC ACID DERIVATIVES ON 

TRANSPLANTED MOUSE LEUKEMIA. Proc. Soc. 

Exp. Biol., N. Y., 1949, 71: 381-387. 

10 refs. Abstracted in: Chem. Abstr., 

1949, 43: 9249d; Biol. Abstr., Bait., 

1951, 25: No. 33787. 

1052 Dodds, E. C. CHEMOTHERAPY IN THE TREATMENT 

OF MALIGNANT DISEASE. Brit. M. J., 1949, 

2: 1191-1193. 17 refs. A survey devoted 

chiefly to the folie acid and anti-folic 

acid group. 

10 Wilkinson J. F. FOLIC ACID. Brit. M. J., 

1948, l: 822-827. Bibliography: p. 826-827; 

see especially: "Leukemias," p. 824. Ab 

stracted in: Chen. Abstr., 1950, 44: 9020h. 

1054 

Â»oil, E. ROUS CHICKEN SARCOMA IN BIRDS TREATED 

Â»ITH FOLIC ACID AND ITS DERIVATIVES: A PATHO 

LOGICAL STUDY. Tr. N. York Acad. Sc., 1948, 

10: No. 3, 83-91. Abstracted in: Chem. Abstr. 

T9~48, 42: 3478a. The morphological features 

of the~Ã¯umor in the untreated and treated 

See 

1667 

birds are compared. Approximately 350 birds 

were used. 

FORMALDEHYDE 

1055 Bass, A. D. and Feigelson, M. RESPONSE OF NOR 

MAL AND MALIGNANT LYMPHOID TISSUE TO NON 

SPECIFIC TISSUE DAMAGE. Proc. Soc. Exp. Biol. 

N. Y., 1948, 69: 339-341. 7 refs. 

See 

2170 

FORMAMIDE 

See 

1463 

FORMAMIDE, 

N-METHYL- 

1056 

Braunsteiner, H. ANTILEUKÃ„MISCHEWIRKUNGVON 

N-METHYLFORMAMID.[ANTI-LEUKAEMICEFFECT OF 

N-METHYLFORMAMIDE.]Klin. 

611-612. rÃ©f. Abstracted 

Wschr., 

in: Excerpta 

1954, 

mÃ«~



65 

FUNGI â€”¿ EFFECT 


see also MUSHROOM EXTRACT; PENICILLIUM 

NOTATUM; PENICILLIUM SPINOLOSUM; 

YEASTS 

1061 

Castelli, V. and Gaggini, V. PHÃ‰NOMÃˆNESDE 

CANCÃ‹ROLYKE PROVOQUÃ‰S PAR OÃ•DIUM ALBICANS. 

[PHENOMENA OF CARCINOLYSIS PRODUCED BY 

OÃ•DIUM ALBICANS.] Schweiz. Zschr. Path. 

Bakt., 1949, 12: 518-522. 5 reÃs. 

Abstracted 

1950, No. 

iniExcerpta 

2829. "When 

med., Sect. 5, 3: 

cells or fragments 

of an adenocarcinoma in mice are immersed in 

a suspension of Oidium albicans, a lysis of 

the cancer cells is seen to occur within 

12 to 24 hours. This lytic effect is much 

more pronounced when the Oidium strains 

have been subjected to repeated inoculation 

into the animal than when the strains have 

been kept on a sugar agar. In vivo, cul 

tures of Oidium albicans do not interfere 

with the development of the chick embryo, 

but, when injected intravenously into mice, 

they prevent the adenocarcinomatous graft 

from developing, or arrest its growth if 

the tumour has already commenced to develop." 


1062 

De Angelis, G. ACTION D'UN MYCETE (STREPTOTHRIX 

FELIS D. A.) SUR LE CANCER DE LA SOURIS. [THE 

ACTION OF A FUNGUS (STREPTOTHRIX FELIS) ON THE 

CANCER OF 

'i'.41-61. 

THE MOUSE.] 

A metabolic 

Oncologia, Basel, 1949, 

substance taken from 

cultures of Streptothrix felis, which had been 

isolated from the granuloma of a cat, was ad 

ministered parenterally to 330 mice with 

Ehrlich's adenocarcinoma. "93.33% of the 

treated animals, amongst them cases with rather 

advanced tumours, showed complete tumour des 

truction. All the tumour animals remained to 

the end of their lives under normal conditions. 

Fertility was not affected. 

tumour-resistant to the same 

The animals proved 

strain of tumour. 

The mycetic material, called by the 

"Mycetin," acts in vivo and attacks 

author 

the tumour 

directly as well as indirectly." 

1063 

Diller, I. C. and Mankowski, Z. LYTIC ACTION 

OF CANDIDA AND SACCHAROMYCES SP. ON SARCOMA 

37 AND EHRLICH ASCITES TUMORS. Cancer Res., 

1954, 14: 848-852. 2 pi. 11 reÃs. 

1064 

Kidd, J. G. EFFECTS OF AN ANTIBIOTIC FROM 

ASPERGILLUS FUMIGATUS FRESENIUS ON TUMOR 

CELLS IN VITRO, 

WITH GLIOTOXIN. 

AND ITS POSSIBLE IDENTITY 

Science, 1947, 105: 511- 

513. 9 refs. Abstracted in: BioTT Abstr., 

Bait., 1949, 4J5: 1947, No.~T076f. 21: No. 20094; Chem. Abstr., 

1064a 

Liass, L. S. OPYT LECHENIÃ•A LEÃ•KOZA MYSHEÃ• 

PREPARATOM IZ GRIBA FUSARIUM. [EXPERIMENTAL 

TREATMENT OF LEUKEMIA IN MICE WITH A PREPARA 

TION OF FUNGUS FUSARIUM.] Vopr. onkol., 

1955, U No. 6, 79-84. tab. 5 refs. Pre 

paration No. 3, obtained from Fusarium sporotrichioides, 

was administered perorally to 18 

mice with spontaneous leukemia and to 31 mice 

with transplanted leukemia. The leucocyte 

count decreased, the size of spleen,liver 

and lymph glands decreased and the mitotic 

activity of leucocytes in the peripheral 

blood was reduced. 

1065 

Meyer, J. R. ACÃ„OANTINEOPLASICA DOS FILTRADOS 

DE CULTURA DE 'ASPERGILLUS FLATOS, LINK' DEMON 

STRADA 'IN VITRO' SOBRE UM TUMOR TRANSPLANTAVEL 

DE CAMONDONGO. [ANTINEOPLASTIC EFFECT OF "ASPER 

GILLUS FLATOS, LINK" CULTURE FILTRATES DEMON 

STRATED IN VITRO ON A TRANSPLANTED MOUSE TUMOR.] 

Arq. biol., S. Paulo, 1947, LÂ£: 239-242. 8 refs. 


1066 

Meyer, J. R. ATIVIDADE ANTINEOPLASICA DO LÃ•QUIDO 

DE CULTURA DE UM COGUMELO DO GENERO PESTALOZZIA- 

DEMONSTRADA "IN VITRO" SOBRE UM TUMOR TRANS- 

PLANTAVEL DE CAMONDONGO. [ANTINEOPLASTIC ACTI 

VITY OF CULTURE FLUID OF FUNGUS OF GENUS PESTA- 

LOZZIA, DEMONSTRATED IN VITRO ON TRANSPLANTABLE 

TUMOR OF RAT.] Arq. Inst. biol., S. Paulo, 

1950-51, 20: 183-192. pi. 6 refs. English 

summary. ~~1T,..this antineoplastic activity is 

possibly due to a substance resulting from 

the carbohydrates used in the culture medium." 

1067 

Meyer, J. R. and Cerrutti, H. AÃ‡AO ANTINEO 

PLASICA DOS EXTRATOS AQUOSOS DO POLYPORUS 

CINNABARINUS, DEMONSTRADA IN VITRO COM IN 

TUMOR TRANSPLANTAVEL DO CAMONDOGO. [ANTI 

NEOPLASTIC ACTIVITY OF AQUEOUS EXTRACTS OF 

POLYPORUS CINNABARINUS, TESTED IN VITRO ON 

A TRANSPLANTED MOUSE TUMOR.] Arq. Inst. 

biol., S. Paulo, 1946, 17: 175-181. 6 refs. 


1068 

Protti. G. NOTIZIE SUL COMPORTAMENTO DI TUMORI 

SPONTANEI DEL TOPO TRATTATI IN VIVO MEDIANTE 

LIEVITI. V. [STUDIES ON THE BEHAVIOR OF 

SPONTANEOUS TUMOURS OF THE MOUSE, TREATED IN 

VIVO WITH YEASTS. 

37: 167-197. pi. 

V.J Tumori, Milano, 

Yeasts were injected 

1951, 

In 

mTce bearing tumors the size of a pea. Micro 

scopic examination showed there was total de 

struction of the malignant cells of solid tu 

mors. 

1069 

Reilly, H. C. and 

TUMOR-RETARDING 

Stock, C. C. STUDIES ON A 

AGENT PRODUCED BY ASPERGILLUS 

FUMIGATUS. Cancer Res., 1951, 11: 366-369. 

7 refs. "Preparations having tKe" ability to 

inhibit growth of sarcoma 180 in mice have 

been extracted from the culture filtrate and 

mycelial pads of Aspergillus fumigatus. Chemi 

cal and electrophoretic data indicate that the 

active principle or principles may be basic 

proteins." The preparations produce marked 

toxic effects in the animal. 

2709 2710 

EFFECT ON MALIGNANT GROWTH, 

ENHANCEMENT OF 

1070 

Meyer, J. R. IMPORTANCIA DA SACAROSE PARA O 

DESENVOLVIMENTO DA ACXO ANTINEOPLASICA NOS 

LÃ•QUIDOS DE CULTURA DE UM COGUMELO. [THE 

IMPORTANCE OF SACCHAROSE IN THE DEVELOPMENT 

OF ANTINEOPLASTIC ACTION OF FUNGUS CULTURE 

FLUID.] Arq. Inst. biol., S. Paulo, 1950- 


THERAPY 

1071 Azevedo, S. EM TORNO DA ACAO TERAPEUTICA DOS 

EXTRATOS DE CERTES COGUMELOS NO CÃ•NCER HUMANO; 

NOTA PREVIA. [THE THERAPEUTIC ACTION OF SOME 

FUNGI EXTRACTS IN HUMAN CANCER; PRELIMINARY 

REPORT.] Rev. brasil, cancerol., 1948, 2: 

5-7. English translation: p. 7-8. Findings 

based on treatment with the extracts of 200 

patients. The effect was chiefly palliative. 

There was a greater survival in several cases, 

a greater cleanliness of ulcerated lesions 

and disinfiltration of tumor tissue. 

See 

139



66 

FUNGI â€”¿ TOXICITY 

1072 Petermann, H. L , Hamilton, M G. and Reilly, 

H. C. THE BASIC PROTEINS OF ASPERGILLUS 

FUMIGATUS WITH TUMOR-INHIBITING PROPERTIES. 

Arch. Biochen., N. Y., 1952, 37: 117-130. 

FUNGICIDES 

1073 

Greco, N. V. DIAGNOSTICO ETIOLOGICO Y TRATA 

MIENTO ETIOLOGICOCANTICRIPTOGAMICO FUNGICIDA) 

DEL CANCER. [ETIOLOGICAL DIAGNOSIS AND TREAT 

MENT (WITH FUNGICIDES) OF CANCER]. 

B. Air., 1950, 57: 1-15. Abstracted 

Sem. 

in: 

med., 

Chem. Abstr., 1350, 44: 9063d. 

2-FURALDEHYDE, 

See 

1688 

HYDROXYMETHYL- 

2-FURALDEHYDE, 5-NITROSEMICARBAZONE 

â€”¿ EFFECT ON MALIGNANT GROWTH 

1074 

Freedlander, B. L., French, F. A. and FÃ¼rst, A. 

EFFECT OF FURAN DERIVATIVES ON TRANSPLANTED 

SARCOMA-180. Stanford M. Bull., 1952, 10: 

310-312. 4 refs. Thirty-nine turan compounds 

Â»ere evaluated for their growth-inhibiting ef 

fect against sarcoma 180 in mice. A slight 

effect was noted after the administration of 

furylacrylamide and 3 of its derivatives. Furoamide 

also showed slight activity. 

1075 

Friedgood, C. E. and Green, M. N. THE EFFECT 

OF NITROFURAZONE 

IN MICE. Cancer 

ON GROWTH OF FIBROSARCOMA 

Res., 1950, 10: 613-615. 

13 refs. "Furacin suspended Irf peanut oil, 

injected subcutaneously, retarded the growth 

of fibrosarcoma S-13 in C3H mice of the 

Andervont subline. The life span of the 

mice was approximately doubled 

ment ...Microscopic examination 

by 

of 

this treat 

the furar intreated 

tumors revealed increased cellular 

degeneration, with lessened mitotic activity. 

Hypertrophy of the adrenal cortex and atrophy 

of the testes 

served in the 

and ovaries have also been 

furacin-treated animals." 

ob 

1076 

Green, M. N. and Friedgood, C. E. ACTION OF 

FURACIN IN DELAYING GROWTH OF A TRANSPLANTED 

FIBROSARCOMA 

N. Y., 1948, 

IN MICE. Proc. Soc. Exp. 

69: 603-604. 3 refs. 

Biol., 

1077 Lannek, N. THE EFFECT OF NITROFURAZONE ON EX 

PERIMENTAL LYMPHOMATOSIS IN CHICKS. Nord. 

Vet. Med., 1954, 6: 693-700. tab. 9 refs. 


3: No. 1769. 

1081 


1078 Prior, J. T. and Ferguson, J. H. CYTOTOXIC 

EFFECTS OF A NITROFURANON THE RAT TESTIS. 


METABOLISM (INCLUDING EFFECTS ON 

METABOLIC PROCESSES) 

1079 

Green, M. N. THE EFFECT OF FURACIN ON METABO 

LISM OF BACTERIA. 

1948, 19:397-406. 

Arch. Biochera., N. Y., 

â€”¿MODEOF ACTION 

1080 

Cramer, D. L. and Dodd, M. C. THE MODE OF ACTION 

OF NITROFURAN COMPOUNDS. I. ACTION VERSUS 

STAPHYLOCOCCUS 

51: 293-303. 

AUREUS. 

6 refs. 

J. Bact., Bait., 1946, 

1081 

Â«Gots, J. S., Jordan, V. E. and Brodie, A. F. 

STUDIES ON ACTION OF NITROFURANS ON BACTERIAL 

ENZYME SYSTEMS; FURACIN(NITROFURAZONE. NITRO 

FURAN DERIVATIVE) INTERFERENCE WITH DYE RE 

DUCTIONS BY ESCHERICHIA COLI. Arch. Biochem., 

N. Y., 1952, 36: 285-298. 

THERAPY 

1082 

Friedgood, C. E. and Ripstein, C. B. THE EF 

FECT OF NITROFURAZONE ON TUMORS OF THE HU 

MAN TESTIS AND PROSTATE GLAND. 

(1951) 1952, 329-333. 6 refs. 

Surg. Forum. 

GARLIC 

see ANTIBIOTICS 

GENERAL AND REVIEW 

1083 Alder, A. DAS PROBLEM DER BEHANDLUNG AKUTER 

LEUKÃ„MIEN. [PROBLEMS IN THE TREATMENT OF 

ACUTE LEUKEMIA]. 

81: 1233-1235. 

Schweiz, med. Wschr , 1951 

1084 

Alder, A. and Zbinden, F. ZUR THERAPIE DES 

LYMPHOGRANULOMS (MORBUS HODGKIN). [THERAPY 

OF LYMPHOGRANULOMA (HODGKINtS DISEASE).] 

Schweiz, med. Wschr., 1953, 83_: 924-927. 

27 refs. 

1085 

Alekseev, G. A. LECHENIE KHRONICHESKIKH 

LEIKOZOV. [TREATMENT OF CHRONIC LEUKE- 

MIAS.] In his: LeÃ¯kozy (Leukemias), 

Moskva, Ministerstvo zdravookhranenifÃ 

SSSR, Tsentral'nyÃ¯ Institut usovershenstvovanifÃ 

vracheÃ¯, 1950, 78-94. A survey 

of the treatment of chronic leukemia, 

chiefly with the Russian nitrogen mus 

tards duamin and embikhin. A few case 

histories are also included. 

1086 â€ž¿ 

Alekseev. G. A. LECHENIE OSTRYKH LEIKO 

ZOV. [TREATMENT OF ACUTE LEUKEMIAS.] 

In his: Leikozy (Leukemias), Moskva, 

Ministerstvo zdravookhraneniia SSSR, 

Tsentral'nyÃ¯ institut usovershenstvovaniÃa 

vracheÃ¯, 1950, 122-126. A 

survey of the treatment of acute leu 

kemia, chiefly with folie acid and 

penicillin. A few case histories are 

also included. 

1087 Andrews, J. R. and Shafer, I. E. Jr. ANTI- 

CANCER DRUGS AND HORMONES AS ADJUVANTS TO 

THE RADIATION THERAPY OF CANCER. North 

Carolina M. J., 1953, 14: 413-420. 11 refs. 

1088 

Artunkal, S. HABIS HASTALIKLARIN SIMYOTERAPISI. 

[CHEMOTHERAPY OF MALIGNANT TUMORS.] Turk tip. 

cemiy. mecmuasi, 1954, 20: 316-324. 19 refs. 

English summary: [addenÃ¤Ã¼m]p. 28. 

1088a 

Astaldi, G., Mauri, C. and Allegri, A. I VELENI 

DELLA MITOSI; I FATTORI CHE INFLUISCONO SÃœLL' 

ATTIVITÃ€ RIPRODUTTIVA DELLE CELLULE CON PARTI 

COLARE RIGUARDO AI REPERTI OTTENUTI SU CUL 

TURE IN VITRO. [MITOTIC POISONS; FACTORS WHICH 

INFLUENCE THE REPRODUCTIVE ACTIVITY OF THE CELL, 

BASED CHIEFLY ON RESULTS OBTAINED FROM IN VITRO 

CULTURES.] Farmaco, Pavia, 1947, 2: 405-451j 

530-573. Approx. 600 refs.



67 

GENERAL & REVIEW (Continued) 

1089 Barta, I. UJABB SZEMPONTOK AZ ANAEMIA PERNICIOSA 

tS A LEUKAEMIÃ„K PATHOGENESISEBEN ES THERÃ„PIÃ„JÃ„BAN. 

[NEW VIEWS ON THE PATHOGENESIS AND THERAPY OF 

ANEMIA PERNICIOSA AND THE LEUKEMIAS.] Orv. 

hetil., 1951, 

of the better 

92: 1677-1683. 11 refs. 

R~n"owncytostatic drugs. 

A review 

Use of 

colcblclne, urethane and folie acid antagonists 

in the various leukemias are discussed. 

1090 

Baserga, A. NUEVOS CONCEPTOS EN EL TRATA 

MIENTO DE LAS LEUCEMIAS AGUDAS. [NEW CON 

CEPTS IN THE TREATMENT OF ACUTE LEUKEMIA.] 

Prensa med. argent., 1953, 40: 2211-2214. 

1091 

Bateman, J. C. CANCER CHEMOTHERAPY. Med. Ann. 

District of Columbia, 1955, 24: 55-62. 

Results obtained by treatmenÃ¯~~withHN2, 

73 refs. 

triethylene 

melamine, triethylene phosphoramide, 

triethylene thiophosphoramide and N-3(oxapentamethylene)N'N'' 

biethylene phosphoramide are 

reviewed. 

1092 

Bauer, K. H. CHEMOTHERAPIE MALIGNER TUMOREN. 

[CHEMOTHERAPY OF MALIGNANT TUMORS]. Verb. 

Deut. Ges. inn. Med., 1949, 55: 365-385. 

Bibliography, p. 384-385. 

1093 

Begemann, H. DIE BEHANDLUNG DER LEUKÃ„MIEN. 

[TREATMENT OF LEUKEMIA.] Deut. med. 

1955, 80: 850-855. Approx. 50 refs. 

Wschr., 

1094 

BenkÃ, S. and Kelemen, E. A LEUKAEMIAKÃ‰RDÃ‰S 

Ã•TTEKINTÃ‰SE. [A REVIEW OF THE LEUKEMIA 

QUESTION.] Orvostud. besztun., 1947, 1: 

6-11. 12 refs. The use of various cEemotherapeutic 

agents is surveyed. 

1095 

Berkman, A. T. RADYOTHERAPIE VE CHIMIOTHERAPIE- 

KOMBINASIYONU DZERINDE TETKIKLERIMIZ. [RE 

SEARCH ON COMBINED RADIOTHERAPY AND CHEMO 

THERAPY.] Turk tip cemiy. mecmuasi, 1952, 

18: 324-41. 

1096 

Bernard, J. COMMENT TRAITER LES LEUCÃ‰MIES. 

[THE TREATMENT OF THE LEUKEMIAS.] 100p. 

Paris, Flammarion, 

p. 95-97. 

1953. Bibliography: 

1097 

Bernard, J. and MathÃ©, G. LA PHYSIOPATHOLOGIE 

DES LEUCÃ‰MIES AIGUÃ‹S TRAITEES. [THE PHYSIO- 

PATHOLOGY OF TREATED ACUTE LEUKEMIA.] Sang, 

Par., 1953, 24: 216-256. 107 refs. Review 

of biochemicaT| pathological and clinical 

effects of therapy known to modify the course 

of acute leukemia, such as transfusion, antifolica, 

ACTH and cortisone; mentioned also 

are treatments with colchicine, urethane, 

nitrogen mustard, radioactive phosphorus, 

thymectomy and sex hormones. Factors in 

fluencing therapeutic results and mechanism 

of total remission are discussed. 

1098 

Beyer, G. DIE PRAXIS DER SYNCARCINOKOLYSE. 

[COMBINEDCHEMOTHERAPYOF CANCER.] Arch, 

tlin. Chir., 1950, 226: 253-270. 22 refs. 


1951, 4: No. 3122. 

1099 Bichel, J. CHEMOTHERAPY IN LEUKEMIA, HODGKIN'S 

DISEASE AND ALLIED DISORDERS. Acta radiol., 

Stockh., 1948, 30: 49-63. 

1100 

Bichel, J. KEMOTERAPI VED LEUKAEMI, LYMFOGRANU- 

LOMATOSE, MYELOMATOSE OG BESLAEGTEDE LIDELSER. 

[CHEMOTHERAPY OF LEUKEMIA, LYMPHOGRANULOMA, 

MYELOMATOSIS AND RELATED DISEASES.] Ugeskr. 

laeger, 1948, 110: 981-987. 4 refs. 

1101 

Bierman, H. R. CHEMICAL AGENTS IN NEOPLASTIC 

DISEASES. (AN EVALUATION OF CHEMOTHERAPEUTIC 

SUBSTANCES FOR CLINICAL MANAGEMENT) California 

M., 1953, 78: 44-58. 172 refs. 

1102 

Bird, R. M., Russo, P. E. and Eliei, L. P. THE 

TREATMENT OF LEUKEMIA. J. Student Am. M. Ass., 

1953, 2: No. 9, 21-24, 26, 83. Abstracted 

in: Leukemia Abstr., 1954, 2: No. 715. 

1103 

Black, M. M. and Speer, F. D. SOME CONSIDERA 

TIONS IN THE THERAPY OF LYMPHOMASAND ALLIED 

DISEASES. 

1668-1671. 

N. York 

53 refs. 

(State) J. M., 1952, 52- 

1104 

Blalock, T. T. NEW METHODS IN THE CHEMOTHERAPY 

OF LEUKEMIA AND LYMPHOMA. Am. 

1954, 5: 382-390. 32 refs. 

Practitioner, 

1105 

Bock, H. E. CHEMOTHERAPIE BEI BÃ–SARTIGEN 

ERKRANKUNGEN DES 

[CHEMOTHERAPY OF 

HAEMATOPOETISCHEN SYSTEMS. 

MALIGNANT DISEASES OF THE 

HEMATOPOIETIC SYSTEM.] Strahlentherapie, 

1951, 8_4: 77-94. 51 refs. 

1105a 

Boni, R. VELENI MITOTICI ED ENERGIA RADIANTE 

NELLA CURA DEI TUMORI MALIGNI. [MITOTIC 

POISONS AND RADIATION ENERGY IN THERAPY OF 

MALIGNANT TUMORS]. Radiol. med., Milano, 

1950, 36: 53-67. 65 refs. 

1106 

Boyland, E. CHEMICAL CARCINOGENESIS AND EXPERI 

MENTAL CHEMOTHERAPY 

1948, 20: 321-341. 

OF CANCER. Yale J. Biol., 


Biol. SEstr., Bait., 1949, 23: No. 15218. 

See especially p. 334-340 for a review of 

cancer-chemotherapeutic agents. 

1107 

Boyland, E. 

Ann. Rev. 

CHEMISTRY OF NEOPLASTIC TISSUE. 

Biochem., 1949, 18: 217-242. 170 

refs. Abstracted in: Chem. Abstr. 1949, 43: 

No. 9225g. Carcinogensis and therapy of can 

cer are reviewed. 

1108 

Boyland, E. CHEMOTHERAPY OF CANCER AND LEUCAE 

MIAS. Oncologia, Basel, 1954, 7: 144-154. 

23 refs. 

1109 

Braunsteiner, H. ÃœBER CHEMOTHERAPIE MALIGNER 

ERKRANKUNGEN. [CHEMOTHERAPY OF MALIGNANT 

DISEASES.] Wien. Zschr. inn. Med., 1953, 

34: 433-441. 26 refs. 

1110 

Brues, A. M. and Jacobson, L. 0. COMPARATIVE 

THERAPEUTIC EFFECTS OF RADIOACTIVE AND CHEM 

ICAL AGENTS IN NEOPLASTIC DISEASES OF THE 

HEMOPOIETIC SYSTEM. Am. J. Roentg., 1947, 

58: 774-782. 22 refs. Discussion on radio 

active isotopes, p. 779-782. 

1111 

Burchenal, J. H. 

LEUKEMIA. In: 

ANTIMETABOLITE 

Antimetabolites 

TREATMENT OF 

and cancer. 

(Rhoads, C. P., ed.) Washington, Am. Ass. 

Advanc. Sc., 1955, 265-283. Bibliography: 

p. 280-283. 

1112 

Burchenal, J. H. THE CHEMICAL ATTACK ON CANCER. 

Ther. Notes. Detr.. 1953, 60: 193-196. 

Abstracted in: Leukemia AbsTr., 1953, 1: No. 

354. 

1113 

Burchenal, J. H. THERAPEUTIC CORRELATION BE 

TWEEN MOUSE AND HUMAN LEUKAEMIA. In: Ciba 

Foundation Symposium on leukaemia research, 

London, 1953. (Wolstenholme, G. E. W. and 

Cameron, M. P., eds.). Boston, Little, 

Brown and Co., 1954, 13-25. 58 refs.



68 


1114 

Burchenal, J H. THE TREATMENT OF LEUKEMIA. 

Bull. N. York Acad. M., 1954, 30: 429-447. 

38 refs. Abstracted in: LeukemTa Abstr., 

1954, 2: No. 978. 

1114a 

Butenandt, A. DER KREBS ALS CHEMOTHERAPEUTISCHES 

PROBLEM. 

Arb. Paul 

[CANCER 

Ehrlich 

AS CHEMOTHERAPEUTIC PROBLEM]. 

Inst., 1954, No. 51, 5-18. 

17 refs. 

1115 

Camus, J. P. TRAITEMENT DES LEUCOSES CHRONIQUES. 

[TREATMENT OF CHRONIC LEUKOSES.] Vie mÃ©d., 

Par., 1954, 35: 621-627. Survey of therapeutic 

agents, including the nitrogen mustards, urethane 

and benzene. 

Â»Ceresa, C., Annovazzi, L. and De Blasiis, M. 

SU ALCUNI RISULTATI DI CHEMIOTERAPIA ANTI- 

NEOPLASTICA. [SOME RESULTS OF ANTINEOPLAS- 

TIC CHEMITHERAPY.] Gior. ital. chemioter., 

1954, 1: 148-153. tab. Abstracted in: 

Excerpta med., Sect. 16, 1955, 3J No. 3184. 

1117 

Sermak, L. and Neumann, J. ATYPICKÃ„ MYELOIDNÃ• 

LEUCEMIE. [ATYPICAL MYELOID LEUKEMIA.] Cas. 

lek. cesk., 1953, 92: 76-78. Abstracted in: 

Leukemia Abstr. 1953", 1: No. 254. "A case 

of chronic myeloid leucemia in a 24-year-old 

female is described, which differed from the 

usual picture by persistent fever and a peri 

odically appearing skin affection...Besides 

x-rays (in early and late stages of the 

disease), the following medicaments were used: 

urethane, Dichloren, Terropteron, penicillin, 

streptomycin, Antistin, and Phenergan. Toward 

the end, temperatures of 40-41Â°C, a high 

degree of splenomegaly, and a considerable 

development of myeloblasts in the 

observed." -Leukemia abstrÂ« 

blood were 

1118 Chalmers, J. N. M. THE TREATMENTOF CHRONIC 

LEUKAEMIA. 657-660. See, Practitioner, p. 658-659 Lond., for antimitotTc" 1951, 167: 

drugs. 

1119 Cocozza, G. ATTUALI ORIENTAMENTI NELLA TERAPIA 

DELLE LEUCEMIE. [CURRENT STATE OF LEUKEMIA 

THERAPY.] Pediatria (Riv.), 1949, 57: 240- 

245. 32 refs. 

CONGRÃˆS INTERNATIONAL D'HEMATOLOGIE. PROGRAMME 

SCIENTIFIQUE. Paris, Expansion Scientifique 

FranÃ§aise. 1954, "RÃ©sumÃ©sdes rapports et 

communications," p. 121-292. Abstracts are 

in French and English. Publication of Con 

gress reports appear in special issues of the 

following Journals: Le Sang; Revue d'hemotologie; 

and Semaine des hÃ´pitaux de Paris. 

1121 Cooley, R. N. THERAPY OF LEUKEMIA, HODGKIN'S 

DISEASE AND ALLIED DISORDERS. Maryland H. J., 

1954 3- 68-73. 14 refs. Abstracted in: 

LeukemTa Abstr., 1954, 2: No. 617. 

1122 Cordeiro, A. J. R. QUIMIOTERAPIA DAS LEUCEMIAS. 

[CHEMOTHERAPY OF LEUKEMIA.] J. ^d. , POrto, 

Ã•952, IjS: 985-95. 

1123 Courts, S. A. THE TREATMENT OF CHRONIC MYELO- 

GENOUS LEUKEMIA. J. Bowman Gray School M 

1949, 7: 87-94. 46 refs. 

1124 

Craver. L. F. RECENT ADVANCES IN TREATMENT OF 

INOPERABLE CANCER. Bull. N. York Acad. M., 

1952, 28: 385-407. 34 refs. 

1125 Craver L. F. TREATMENT OF CHRONIC FORMS OF 

MALIGNANT LYMPHOMAS AND LEUKEMIAS. Med. 

Clin. N. America, 1949, 527-540. 

1126 

Creech, H. J. and Greenspan, E. M. CARCINO- 

GENESIS AND CHEMOTHERAPY OF TUMORS. In: 

Basic Science Notes (U.S.Army Med. Dep. Res. 

Grad. Seh.) 1948, 3: No. 4, 1-12. Experi 

mental chemotherapy of cancer: p. 5-8. 

1127 

Dameshek, W. THE OUTLOOK FOR THE EVENTUAL CON 

TROL OF LEUKEMIA. N. England J. M., 1954, 

250: 131-139. 42 refs. The greater part of 

Ã¯Ã¯Ã¯Ts article is on etiology, knowledge of 

which the author considers essential in the 

development of 

for. leukemia. 

a specific therapy or cure 

The standard chemo-therapeutic 

agents are discussed. 

1128 

Debray, J. 

HODGKIN. 

LE TRAITEMENT DE LA MALADIE DE 

[TREATMENT OF HODGKIN'S DISEASE]. 

Therapie, Par., 1954, 9: 106-118. 

1129 

Diamond, H. D. RECENT ADVANCES IN THE MANAGE 

MENT 0F LYMPHOMAS 

N. America, 1953, 

AND LEUKEMIAS. Med. Clin. 

843-867. 41 refs. A de 

tailed discussion of the use of ionizing 

radiations, chemotherapy, viruses and surgery. 

Special emphasis is placed on ionizing radia 

tion and chemotherapeutic agents. 

1130 

Di Guglielmo, G. STATO ATTUALE DELLA CURA DELLE 

LEUCEMIE. [PRESENT STATE OF LEUKEMIA 

Rass. clin, se., 1955, 3_1: 67-69. 

THERAPY.] 

1131 

Di Pietro, S. and Giacomelli, V. PROBLEMI 

TEORICI E CLINICI DELLA CHIMIOTERAPIA DEI 

TUMORI CON SOSTANZE ANTIMITOTICHE. [THEO 

RETICAL AND CLINICAL PROBLEMS OF TUMOR THERA 

PY WITH ANTIMITOTIC AGENTS.] Minerva med., 

Tor., 1954, 45: pt. 1, 373-379. 

1132 Dodds, E. C. CANCERIGENES ET ANTICANCERIGENES. 

[CAÃ‘CEROGENIC AND ANTI-CANCEROGENIC AGENTS.] 

U Farmaco, Pavia, 1948, 3: 565-579. 34 reÃs. 


3: No. 1657. See especially p. 570-578 for 

cancer chemotherapeutic agents. 

^Domagk, G. ÃœBER STAND UND PROBLEM DER GE- 

SCHWULSTFORSCHUNG. [ON THE STATUS AND 

PROBLEMS OF TUMOR RESEARCH.] Strahlen 

therapie, 1950, 83: 565-588. 31 refs. 

Following a reviÃ«Ã¯Ã¯ of the literature on 

cancer research, chemotherapy of cancer 

is discussed, especially with cytostatic 

agents and tissue extracts. 

1133a 

Drieux, H. QUELQUES ESSAIS DE TRAITEMENT DU 

CANCER CHEZ LES ANIMAUX DOMESTIQUES. 

MENT OF CANCER IN DOMESTIC ANIMALS.] 

[TREAT 

Lutte 

cancer, Par., 1947, 25: 36-40. 17 refs. The 

same paper is presenÃ¯Ãª"din: Rev. path, comp., 

Par., 1946, 46: 438-441. 

1133b 

Druckrey, H. EXPERIMENTELLE GRUNDLAGEN DER 

CHEMOTHERAPIE DES KREBSES. [EXPERIMENTAL 

BASIS OF CANCER CHEMOTHERAPY.] Deut. med. 

Wschr., 1952, 77: 1495-1498, 1534-1537. 


1133C 

nruckrev H KREBS; DER NEUESTE STAND DER 

FORSCHUNG IN THEORIE UND PRAXIS. IV. EX 

PERIMENTELLE GRUNDLAGEN DER CHEMOTHERAPIE 

ml KREBSES. [REVIEW OF CANCER RESEARCH IN 

THEORV AND PRACTICE. IV. EXPERIMENTAL BASIS 

FOR CHEMOTHERAPY IN CANCER.] Medizinische, 

1953, 1025-1032. Approx. 90 refs. General 

review and discussion of theories relating to 

cancerogenesis and cancer chemotherapy.



69 


1134 Dubois-FerriÃ¨re, H. L'ORIENTATION ACTUELLE DE 

LA THERAPEUTIQUE DES LEUCEMIES. [RECENT 

TRENDS IN THE TREATMENT OF LEUKEMIAS.] 

Actual, hemat., 1953, 77-118. 166 reÃs. 

Abstracted in: Leukemia Abstr., 1953, 1: 

No. 359. 

1135 

Dubois-FerriÃ¨re, H. PROBLEMES ACTUELS DE 

DIAGNOSTIC ET DE TRAITEMENT DES LEUCEMIES 

AIGUÃ‹S. [PRESENT-DAY PROBLEMS IN THE DIAGNOSIS 

AND THERAPY OF ACUTE LEUKEMIAS]. Rev. mÃ©d. 

Suisse rom., 1955, 75: 422-441. See p. 433- 

441 for therapy. 

1136 

Dubois-FerriÃ¨re, H. LES TRAITEMENTS ACTUELS DES 

LEUCÃ‰MIES. [CURRENT TREATMENT OF LEUKEMIA.] 

Praxis, Bern, 1949, 637-644. 54 reÃs. 

Abstracted in: Index analyt. cancer., Par., 

1950, 2U No. 746. 

1137 

Dubois-FerriÃ¨re, H. LES TRAITEMENTS ASSOCIÃ‰S 

DES LEUCOSES. RESULTATS Ã‰LOIGNES. [COMBINED 

TREATMENTS OF THE LEUCOSES. LATE RESULTS.] 

Sang, Par., 1953, 24: 529-533. Treatment of 

leukemias, which combined the action of cytostatics(triethylenemelamine, 

arsenic, urethane 

or radiotherapeutics) and cytophylaxis by me 

tallic catalysers(oligo-roetals) produced total 

haematological and clinical remission of a 

duration of 3-10 months in 3 cases of subacute 

leukemia. In 3 cases of acute leukemia a 

definite clinical and haematological remission 

was obtained, but without normalization of 

the myelogram. In cases in which the re 

mission was total it has been possible to 

obtain remissions after relapses. 

1138 

Duran Lopez, J. and Rodriguez Verardini, M. 

QUIMIOTERAPIA ANTICANCEROSA. [CANCER CHEMO 

THERAPY.] Farmacoter. actual, Madr., 1948, 

5: 

1139~ 

156-163. 22 rets. 

Â»Dustin, P., Jr. L'APPORT DE LA CHIMIOTHERAPIE 

AU TRAITEMENT DES LEUCEMIES HUMAINES. [CHEMO 

THERAPY OF HUMAN LEUKEMIA.] Ann. med. chir. 

centre, Tours, 1954, 10: 78-100. Review 

including successful results obtained with 

myleran in chronic myeloid leukemia. 

1140 

Dust in, P., JT. QUELQUES DONNÃ‰ES RÃ‰CENTES SUR 

L'UTILISATION DE LA CHIMIOTHÃ‰RAPIE ET DES 

RADIOISOTOPES DANS LA LUTTE CONTRE LE CANCER. 

[RECENT DATA ON USE OF CHEMOTHERAPY AND 

RADIOISOTOPES AGAINST CANCER.] Bruxelles 

mÃ©d., 1947, 27: 2605-2616. 

1141 

Erf, L. A. HUMAN LEUKEMIA, WITH EMPHASIS UPON 

RECENT THERAPEUTIC EXPERIENCES. Pennsylvania 

M. J., 1950, 53: 1172-1181. "The treatment 

of leukemia has" been approached by using agents 

which (1) inhibit enzymes, (2) arrest mitosis, 

(3) compete for metabolites or nutrients, (4) 

stimulate cell metabolism or inhibit it, and 

(5) sustain cellular life." 

1142 

Euler, H. von and Hasselquist, H. ZUR CHEMO 

THERAPIE DER TUMOREN. [CHEMOTHERAPYOF 

TUMORS.] Arkiv kemi, 1953, 6: 123-132. 

Abstracted 

No. H90Kb. 

in: Chem. Abstr., 1953, 47: 

1143 

Farreras Valenti, P. QUIMIOTERAPIA DE LAS 

NEOPLASIAS MALIGNAS. REVISION DE LAS PRINCI 

PALES SUSTANCIAS QUÃ•MICAS CITOSTATICAS, INHI 

BIDORAS DEL DESARROLLO CELULAR TUMORAL T, EN 

ESPECIAL, DE LAS ANTIHEMOBLASTOMATOSAS. 

[CHEMOTHERAPY OF MALIGNANT NEOPLASMS; REVIEW 

OF PRINCIPAL CYTOSTATIC SUBSTANCES MAINLY 

ANTIHEMOBLASTIC ONES, WHICH INHIBIT THE DE 

VELOPMENT OF THE TUMOR CELL.] Rev. clin. 

espaK., 1949, 34: 412-424. 72 refs. 

1144 

FernÃ¡ndez LÃ³pez, N. A. LA QUIMIOTERAPIA MODERNA 

EN EL TRATAMIENTO DEL CANCER. [MODERN CHEMO 

THERAPY 

Mexico, 

IN THE 

1955. 

TREATMENT OF CANCER.] 47p. 

(Tesis - Univ. de Mexico) 35 

refs. The use of urethane, folie acid analogs, 

cortisone, ACTH, nitrogen mustards, derivatives 

of ethyleneimine, and hormones are discussed. 

1145 

Fiehrer, A. and Hofstein, J. CONTRIBUTION X 

L'Ã‰TUDE DE LA LEUCÃ‰MIE LYMPHOÃ•DE. [CONTRI 

BUTION TO THE STUDY OF LYMPHOID LEUKEMIA.] 

Rev. path, gen., Par., 1953, 53; 792-798. 

1 case history. 

1146 Fieschi, A. TERAPIA DELLE LEUCEMIE (CON UN 

ACCENNO ANCHE ALLE ALTRE GRAVI EMOPATIE). 

[THERAPY OF LEUKEMIAS; WITH REFERENCE ALSO 

TO OTHER MALIGNANT DISEASES.] An. Inst. 

med. trop., Lisb., 1950, 7: Suppl., 177- 

191. 

1147 

Fleischhacker, H. DER EINFLUSS DER THERAPIE 

BEI LEUKÃ„MIEN. [EFFECTIVE THERAPY 

MIAS]. Klin. Med., Wien, 1951, 6: 

OF LEUKE 

405-409. 

24 refs. 

1148 

Fleischhacker, H. FORTSCHRITTE IN DER BEHAND 

LUNG VON BLUTKRANKHEITEN. [PROGRESS IN THE 

TREATMENT OF BLOOD DISEASES.] Wien. rned. 

Wschr., 1949, 99: 187-191. Approx. 65 refs. 

1149 

Focaccia, S. RECENTI CHEMIOTERAPICI IN ONCO 

LOGIA. [RECENT PROGRESS IN THE CHEMOTHERAPY 

OF CANCER.] Chimica, Italy., 1954, 30: 259- 

264. Approx. 50 rÃ©fs. 

1150 

Fonseca, Salles A. de, Costa, P. D. da and 

Castro^ A. de LEUCEMIA MIÃ‰LOIDE CRONICA. 

III. ESTUDO CLÃ•NICO TERAPEUTICO A LUZ DAS 

MODERNAS AQUISICÃ–ES. [CHRONIC MYELOID 

LEUKEMIA. III. CLINICAL THERAPEUTIC STUDY 

IN THE LIGHT OF MODERN KNOWLEDGE.] Hospital, 

Rio, 1952, 41: 357-379. 61 refs. 

1151 Forkner, C. E.,â€¢ Burchenal, J. H., Craver, L. F., 

Reznikoff, P. and Rosenthal, N. DISORDERS OF 

THE BLOOD: PANEL MEETING ON THERAPEUTICS. 


See section of the panel discussion consisting 

of a talk by Dr. Burchenal on therapy of acute 

and chronic leukemias p: 461-470. Compare 

with: Bull. N. York Acad. M., 1954, 30: 429- 

447. 

1152 

Fornara, P. 

FANTILI. 

CONSIDERAZIONI 

[CONSIDERATIONS 

SULLE LEUCEMIE IN 

ON INFANTILE LEU- 

KENIAS.] Boll, oncol., Roma, 1952, 26: 101- 

194. Bibliography: p. 189-194. Abstracted 

in: Leukemia Abstr., 1953, 1: No. 211. See 

p. 154-188 for therapy. 

1153 

Fountain, J. R. THE CHEMOTHERAPY OF ACUTE LEU 

KEMIA: A REVIEW OF ITS 

Edinburgh M. J., 1954, 

PRESENT STATUS. 

(Â¡1 : 69-83. 81 refs. 

1154 

Frey, R., Fischer-Wasels, J , Streicher, H. J., 

Tuchmann, M. and Wilcke, O. KLINISHCE UND 

HISTOLOGISCHE BEOBACHTUNGEN 

THERAPIE MALIGNER TUMOREN. 

BEI DER CHEMO 

[CLINICAL AND 

HISTOLOGICAL STUDY IN THE CHEMOTHERAPY OF 

MALIGNANT TUMORS.] Arch. klin. 

268: 283-298. Bibliography: p. 

Chir., 1951, 

297-298.



70 


1155 

Fries, S. I. de NIEUWE BEHANDEHNOGSWIJZEN VAN 

LEUCAEMIE. I. ACUTE LEUCAEMIE. II. CHRO 

NISCHE LEUCAEMIE. [NEW TREATMENTS OF LEU 

KEMIA. 

KEMIA.] 

I. ACUTE LEUKEMIA. 

Ned. tschr. geneesk., 

II. CHRONIC LEU 

1952, 96: 3002- 

3006, 3081-3085. 

1156 

GÃ¤nsslen, M. EINE ERFOLGREICHE BEHANDLUNG DER 

LYMPHOGRANULOMATOSE. 

HODGKIN'S DISEASE.] 

[SUCCESSFUL THERAPY OF 

Verb. Deut. Ges. inn. 

Med., 1949, 55: 398-400. 

1157 

GSnsslen, M. FORTSCHRITTE IN DER BEHANDLUNG 

VON LEUKÃ„MIENUND GRANULOMEN. [PROGRESS IN 

THERAPY OF LEUKEMIAS AND GRANULOMASl . 

haeraat., Lpz., 1951, 70: 59-70. 

Fol. 

1158 

GÃ¤nsslen, M. FORTSCHRITTE IN DER BEHANDLUNG 

VON LEUKÃ„MIENUND LYMPHOGRANULOMEN [PROG 

RESS IN THE THERAPY OF LEUKEMIA AND LYMPHO- 

GRANULOMA]. Neue raed. Welt, 1950, l- 1194- 

1198. 

1159 

GÃ¤nsslen, M. and Martin, H. KOMBINIERTE CHEMI 

SCHE UND STRAHLENTHERAPEUTISCHE BEHANDLUNG 

DES LUNGENKREBSES. [COMBINED CHEMOTHERAPY 

AND RADIOTHERAPY IN THE TREATMENT OF LUNG 

CANCER.] Verb. Deut. Ges. 

57: 381-388. Discussion: 

inn. Med., 

p. 384-388. 

1951, 

1160 

GÃ¤nssleff, M. FORTSCHRITTE IN DER BEHANDLUNG 

VON TUMOREN, LEUKÃ„MIENUND GRANULOMSN. [PROG 

RESS IN THE TREATMENT OF TUMORS, LEUKEMIA AND 

GRANULOMA]. Strahlentherapie, 1950, 83: 183- 

197. 

1161 

Gallico, E. I MODERNI ORIENTAMENTI DELLA 

CHEMIOTERAPIA DEI TUMORI. [MODERN TRENDS IN 

CHEMOTHERAPY OF TUMORS]. Minerva med., Tor , 

1952, 43: pt. 2, 1264-1278. 

1162 

Gardkias, C , Leonard, B. J. and Wilkinson, J. t. 

CHRONIC LEUKAEMIAS. In: MODERN TRENDS IN 

BLOOD DISEASES. (WilETnson, J. E., ed.). 

New York, P. B. Hoeber, 1955, 229-246. 84 refs 

See especially, Treatment, p. 233-244. Review 

of chemotherapeutic agents noting effective 

dosage and toxic effects. 

1163 

Gellhorn, A. CLINICAL CANCER CHEMOTHERAPY. 

Proc. Nat. 

!_: 24-34. 

Cancer Conf., (1952) 1954, 

Discussion: p. 32-34. 

2. Conf., 

1164 

Gellhorn, A. CLINICAL CANCER CHEMOTHERAPY. 

Acta UniÃ³ internat, cancr., 

11: 143-154. Ill refs. 

Louvain, 1955, 

1165 

Gellhorn, A. A CRITICAL EVALUATION OF THE CUR 

RENT STATUS OF CLINICAL CANCER CHEMOTHERAPY. 


1166 

Gellhorn, A. RECENT DEVELOPMENTS IN LABORATORY 

AND CLINICAL 

Bait., 1953, 

CANCER CHEMOTHERAPY. J. Urol., 

70: 813-826. 35 refs. 

1167 

Gellhorn, A. and Holland, J. F. NEOPLASTIC 

DISEASES; MEDICAL CARE IN ADVANCED CANCER. 

Annual Rev. M.. 1954, 5: 183-206. Chemo 

therapy: p. 193-198. T32 refs. 

1168 Girard, M. TRAITEMENT DE LA MA'jADIE DE HODGKIN. 

Â¡TREATMENTOF HODGKIN'S DISEASE]. J. mea. 

Lyon, 1954, 35: 233-237. Discussion. 

1169 

Graul, E. H. CHEMOTHERAPIE BÃ–SARTIGER TUMOREN. 

[CHEMOTHERAPY OF MALIGNANT TUMORS.] Hautarzt, 

1954, 5: 97-106. refs. Review article deal 

ing wiÃ¯Ã¯h the biochemical basis of cancer 

chemotherapy, the chemistry and pharmacology 

of chemotherapeutic agents and results of 

clinical investigations. 

1170 

Haddow, A. DISCUSSION OF THE CHEMOTHERAPY OF 

THE RETICULOSES. Proc. R. Soc M , Lond 

1953, 46: 692-696. 

1171 

Haddow, A. NEOPLASTIC DISEASES(CANCER). Annual 

Rev. M , 1955, 6: 153-186. See "Chemical and 

endocrine treatment." p: 168-172. Approx. 

120 refs. 

1172 

Haddow, 

Brit. 

A. NOTE ON THE CHEMOTHERAPY 

M. Bull., 1947, 4: 417-425. 

OF CANCER. 

109 refs. 

A review of the use of estrogens, 2-chloroethylamines 

and urethane. 

1173 

Hall, B. E. CHEMOTHERAPY OF LEUKAEMIA AND 

ALLIED DISORDERS. Med. Clin. N. America, 

1953. 1755-1767. Treatment with nitro 

gen mustards, TEM, R-48, urethane, Myeleran, 

arsenicals, hormones, folie acid 

antagonists and adenine antagonists is re 

viewed. 

1174 

Â»Hayhoe, F. G. and Whitby, L. THE MANAGEMENT 

OF ACUTE 

Haemat., 

LEUKAEMIA IN ADULTS. Brit. 

1955, 1: 1-19. References: 

J. 

p. 18- 

19. 

1175 

Heilmeyer, L. ANFANGE EINER CHEMOTHERAPIE NEO 

PLASTISCHER ERKRANKUNGEN. [CHEMOTHERAPY OF 

NEOPLASTIC DISEASES.] Schelz. med. Wschr., 



A review. "The report concerns itself with 

the compounds affecting the cell nucleus and 

its function: colchicine, arsenic, folie acid, 

urethane, nitrogen mustard. The author em 

phasizes the relationship of the mutative ard 

carcerogenic effect of these compounds to 

their destructive effect on neoplastic cells. 

All these results may be explained by the 

effect on the chromosomes. This discussion 

is followed by a short survey of the effect 

of radioactive isotopes, certain metal salts, 

pyrogens, and hormones. It is emphasized 

that from a practical clinical point of 

view, the usefulness of 

limited."-Excerpta med. 

all these products is 

1176 

Heilmeyer, L. PRINZIPIELLES ÃœBER DIE WIRKUNG 

DER CYTOSTATICA. [FUNDAMENTALS OF CYTOSTA- 

TIC ACTIVITY.] Fol. haemat., Lpz., 1951, 

70: 43-51. 

1177 

Heilmeyer, L. THERAPIE DER NEOPLASTISCHEN 

BLUTKRANKHEITEN. [THERAPY OF NEOPLASTIC 

BLOOD DISEASES.] Bull. Schweiz. Akad. med. 

Wiss., 1954, 

p. 178-179. 

10: 159-179. Discussion: 

A~~review. "Since the intensity 

of proliferation of a carcinoma is usually 

less than that of normal bone marrow, the 

cytostatica are mostly unsuitable for the 

treatment of carcinoma. On the other hand, 

they are very suitable for more strongly 

proliferating blood neoplasm." 

1178 

Heilmeyer, L. THERAPIE MIT CYTOSTATISCHEN STOFFEN. 

[THERAPY WITH CYTOSTATIC SUBSTANCES.] Acta haemat. 

Basel, 1949, 2: 25-42. 33 refs. Abstracted in: 

Biol. Abstr., Bait., 1949, 23: No. 26456; Chem. 

Abstr., 1949, 43: No. 9263f. "Therapeutic results 

with urethane,"rfitrogen-mustards, pentamidine 

and estrogens are reviewed. The possible mode 

of action is discussed. In the author's opinion 

all these substances act not only by inhibiting 

mitosis, but exert a specific effect on different 

neoplastic diseases. They sensitize the effect 

of x-ray treatment also." -Biol. Abstr.



71 


1179 Heilmeyer, L. THERAPIE MIT CYTOSTATISCHEN 

STOFFEN, WIRKUNGSPRINZIP, LEISTUNGEN UND 

GRENZEN. [THERAPY WITH CYTOSTATIC AGENTS, 

ACTION, RESULTS 

therapie, 1952, 

AND 

86: 

LIMITS.] 

411-421. 

Strahlen 

A review 

discussing in parTicular the action and 

effect on neoplasms of urethane, nitrogen 

mustard, TEH, hormones and radioactive 

isotopes. 

1180 

Heilmeyer, L. THERAPIE MIT ZYTOSTATISCHEN 

STOFFEN. [THERAPY WITH CYTOSTATIC SUB 

STANCES.] Ars medici, Basel, 1947, 37: 

676-682. A survey. The action of ure 

thane, nitrogen mustard and diamidines 

is discussed. 

1181 

Heilmeyer, L. ZUR CHEMOTHERAPIE NEOPLASTISCHER 

ERKRANKUNGEN. [CHEMOTHERAPY OF NEOPLASTIC 

DISEASES.] Naturwissenschaften, 1950, 37j 


1950, 44: No. 8526h. "A review of the 

Abstr., 

effect 

of chemicals (cytostatics) on the cells of 

tumors. Such chemicals are either cell 

nucleus poisons like colchicine or trypaflavine, 

urethans, mustard gases, stilbamidine, etc., 

or antigrowth materials like aminopterine, 

metal salts. Other active materials are 

radioactive substances, pyrogenic materials 

(polysaccharides) and hormones (estrogen, 

androgen, choline)." -Chem. Abstr. 

1182 

Heilmeyer, L. and Merk, R. THERAPIE DER 

LEUKÃ„MIEN UND DER LEUKEMIEÃ„HNLICHEN ERKRAN 

KUNGEN. [TREATMENT OF LEUKEMIA AND SIMILAR 

CONDITIONS.] Praxis, Bern, 1949, 38: 63-72. 

64 refs. Treatment with arsenicals, urethane, 

colchicine, nitrogen mustards, radioactive 

isotopes, metals, aminopterin, stilbamidine 

and pentamidine is discussed. 

1183 

Heller, J. R. POTENTIALS OF CHEMOTHERAPY IN 

CANCER. Mil. M., 1955, 116: 175-178. 12 refs. 

1184 

Hemmeler, G. CLINIQUE ET THÃ‰RAPEUTIQUE DU LYM- 

PHOGRANULOME. [CLINICAL PICTURE AND TREAT 

MENT OF LYMPHOGRANULOMA.] 

1953, 20: ser. A, 261-278. 

Helvet. med. 

Discussion: 

acta., 

p. 275- 

278. Summary in: MÃ©d. & hyg., GenÃ¨ve, 1953, 

11: No. 249, 309-310. 32 refs. tab. 

1185 

Hemmeler, G. TRAITEMENT DES LEUCÃ‰MIES CHRONIQUES. 

[TREATMENT OF CHRONIC LEUKEMIAS] . 

Suisse rom., 1955, 75: 442-449. 

Rev. mÃ©d. 

1186 

HÃrler, T. CHEMIE UND ARZNEIFORM DER MEDIKAMENTE 

ZUR BEKÃ„MPFUNG DER KREBSKRANKHEIT. [CHEMISTRY 

AND FORMS 

CANCER.] 

OF MEDICAMENTS FOR THE COMBAT OF 

Schweiz. Apoth. Ztg., 1949, 87: 569- 

579. A review; among the agents discussed are 

various tissue extracts, vitamins and cytostatic 

compounds. 

1187 

Holland, J. f. THE CHEMICAL CONTROL OF CANCER. 

Pub. Health Rep., Wash., 1954, 69: 1151-1166. 

85 refs. 

1188 

Homburger, F. S. and McCombs, R. P. CHEMOTHERA 

PY IN MALIGNANT DISEASE. Bull. N. England 

Center, 1948, 10; 255-265. 3 refs. 

M. 

1189 

Â»Homer, R. F. CHEMICAL RADIOMIMETIC AGENTS AND 

CANCER. Science News Lett., 1954, 34: 69- 

83. 

1190 

Huguenin, R. and Bourdin, J. LA MEDICATION 

CHIMIQUE EN CLINIQUE CARCINOLOGIQUE. [CHEMI 

CAL MEDICATION IN CLINICAL CANCEROLOGY.] 

ThÃ©rapie, Par., 1950, 5: 163-170. 

agents discussed are th~e nitrogen 

Among the 

mustards 

and their derivatives, vitamins and antago 

nists as well as a few cytotoxic compounds. 

1191 

Huguenin, R. and Bourdin, J. QUELQUES TRAITE 

MENTS RECENTS DU CANCER. [MODERN THERAPY OF 


6-16. 

Monde mÃ©d., Ã©d. fr., 1950, 60: 

1192 

Huguenin, R., Bourdin, J. S. and Pierart, A. 

ETAT ACTUEL DE LA THÃ‰RAPEUTIQUE ANTI- 

CANCÃ‰REUSE. [PRESENT STATE 0F CANCER THERAPY.] 

Gaz. mÃ©d. France, 1951, Spec. No.,127-133. 

A 

1193 

discussion. 

. 

Illovici, D. E. NOUVEAUX TRAITEMENTS DU CANCER 

[NEW CANCER TREATMENTS]. 

1951, 27: 535-543. 

Homoeopath, fr., 

1194 

INTERNATIONAL CONGRESS OF HEMATOLOGY. PROCEED 

INGS. New York, GruÃ±e & Stratton. Congr. 

3-4, (1950) 1951-U952) 1954. Meetings are 

biennial. 1st 4 meetings called the Proceed 

ings of the International Congress of the 

International Society of Hematology. The 

Proceedings of the 3rd congress(Cambridge, 

Engl., 1950) is the first to appear as a 

separate publication. Contributions in these 

proceedings appear either as complete manu 

scripts, as abstracts or as titles of presen 

tations made before the congress. They are 

not separately indexed in this bibliography, 

as most reports have been published in jour 

nals. For Congr.^5(Paris, 1954) see CongrÃ¨s 

International d1hÃ©matologie. Programme 

scientifique. 

1195 

Introzzi, P. and Marinone, G. LA POSIZIONE DEI 

TRATTAMENTI CHIMICI CITOSTATICI NELLA TERAPIA 

DELLE EMOPATIE PRODUCTIVE MALIGNE CHRONICHE. 

[THE TREATMENT OF CHRONIC MALIGNANT PROLI- 

FERATIVE DISEASES OF THE BLOOD *ITH CHEMICAL 

CYTOSTATICS.] Haematologica, Pavia, 1953, 

37: 1195-1274. 77 refs. French, English and 

German summaries. Abstracted in: Excerpta 

med., Sect, lo, 1954, 2: No. 5071. 

1196 

Iskraut, H. ZUR THERAPIE DER TUMOREN. [THERA 

PY OF TUMORS.] Hippokrates, Stuttg., 

25: 580-584. A discussion of various 

1954, 

treat 

ments and their theoretical basis. Arsenics, 

choline, yeast, coniine, ether, Iscador and 

Plenesol are among the substances discussed. 

1197 

Issels, J. GRUNDLAGEN UND RICHTLINIEN FÃœR EINE 

INTERNE KREBSTHERAPIE. [BASIC CONCEPTS AND 

APPLIED INTERNAL CANCER TREATMENT.) 91p. 

Stuttgart, Hippokrates, 1953. 74 refs. Bio 

logical or homeopathic treatment of cancer. 

1198 

Jamar, B. LYMPHOGRANULOMATOSIS. [HODGKIN'S 

DISEASE.] Zdrav. vest., Ljubljana, 1954, 

23: 106-113. 10 refs. Experience with 

nitrogen mustard(aminoiperit), cortisone, 

ACTH, Fowler's solution, x-rays and blood 

transfusion in treating cases of lymphogranulomatosis 

is reported. Of 45 patients 

25% were still alive 3 years following 

treatment and 11.7% after treatment. 

1199 

Jeschal, E. ZUR INTERNEN BEHANDLUNG INOPERABLER 

KREBSKRANKER. [IINTERNAL TREATMENT OF INOPER 

ABLE CANCER PATIENTS.] Zschr. arztl. Fortbild., 

1955, 49: 339-342. 74 refs. 

1200 

Josserand, A., Chabert, H. and Chappet, J. 

RÃ‰SULTATSACTUELS ET MODE D'ACTION DE LA 

THÃ‰RAPEUTIQUEPALLIATIVE DES CANCERS Ã‰PI - 

THÃ‰LIAUXBUCCO-PHARYNGOLARYNGES PAR LA 

DESINFILTRATION PÃ‰RI-FOCALE ASSOCLÃ‰EAUX 

CHIMIOTHÃ‰RAPIES CELLUICIDES. [RESULTS 

AND MECHANISM OF PALLIATIVE THERAPY OF 

BUCCO-PHARYNGO-LARYNGEAL EPITHELIAL CAN 

CER BY PERIFOCAL DISINFILTRATION COMBINED 

WITH CELLULICIDAL CHEMOTHERAPY.] J. mÃ©d. 

Lyon, 1954, No. 821, 285-289.



72 


1201 

Karnofsky, D. A. THE BASES FOR CANCER CHEMO 

THERAPY. Stanford M. Bull., 1948, 6: 257- 

269. 15 refs. 

1202 Karnofsky, D. A. CHEMICAL AGENTS USED IN THE 

TREATMENTOF INOPERABLEANDFAR-ADVANCED 

NEOPLASTIC DISEASE. In: Monographs in 

Medicine, ser. l (W.B. Bean, ed.) Baltimore, 

Williams & Wilkins, 1952, p. 582-636. 124 

refs. 

1203 Karnofsky, D. A. CHEMOTHERAPY OF NEOPLASTIC 

DISEASE.. I. METHODS OF APPROACH. N. 

England J. M., 1948, 239: 226-231. 36 refs. 

Abstracted in: Chem. AWtr., 1948, 42: 7880Ã•. 

A review. 

1204 

Karnofsky, D. A CHEMOTHERAPY OF NEOPLASTIC 

DISEASE. 

THERAPY. 

II. TRENDS IN EXPERIMENTAL CANCER 

N. England J. M., 1948, 239: 260- 

270. 177 refs. Abstracted in: Chem. Abstr., 

1948, 4j2: 7880Ã•. 

1205 Karnofsky, D. A. CHEMOTHERAPY OF NEOPLASTIC 

DISEASE. III. AGENTS OF CLINICAL VALUE. 

N. England J. M., 1948, 239: 299-305. 66 


42: 8344h. 

1206 Karnofsky, D. A. THE DISCIPLINE OF CANCER CHEMO 

THERAPY. Geriatrics, 1954, 9: 292-302. 23 

refs. 

1207 Karnofsky, D. A. HORMONAL AND CHEMICAL METHODS 

IN THE TREATMENT OF CANCER. Postgrad. M., 

1955, 17: 514-522. 

1208 

KassirskiÃ¯, I. A. 0 KHIMIOTERAPII LEIKOZOV 

(OBZOR NOVOÃ• LITERATURY). [CHEMOTHERAPY 

OF LEUKOSIS 

Klin, med., 

(REVIEW 

Moskva, 

OF RECENT LITERATURE).] 

1950, 18: No. 11, 11- 

21. 35 refs. Review of tEÃ« therapeutic 

effects of urethane, nitrogen mustard, 

stilbamidine, folie acid antagonists and 

penicillin on leukemias in man. 

1209 Kauer G. L., Jr. TREATMENT OF THE LEUKEMIAS. 

Am. J. M. Se., 1948, 216: 581-595. 89 refs. 

1210 Kautzsch, E. ZUR THERAPIE DES INOPERABLEN 

LUNGENKREBSES. [TREATMENT OF INOPERABLE 

PULMONARY CANCER.] Deut. med. Wschr., 1950, 

75: 1655-1658. Abstracted in: Index analyt. 

cancer., Par., 1951, 22; No. 691. Treat 

ment with diethyldioxystilbene(Cyren), nitro 

gen mustard, urethane, colchicine and arsenic 

is reported. No improvement was noted. In 

some cases the effects seemed to be detri 

mental. 

1211 

Â»Khanolkar, V. R. BIOLOGY, CHEMISTRY AND CAN 

CER. Ind. J. M. Sci., 1949, 3: 16-88. 


3: No. 1094. 

1212 Klima R FORTSCHRITTE IN DER INTERNEN THERAPIE 

DERLEÃKAMIEN UND Ã„HNLICHER MALIGNER BLUTKRANK 

HEITEN. [PROGRESS IN THE TREATMENT OF LEUKEMIA 

AND RELATED MALIGNANT HEMATOPATHIES.] Radlol. 

austr., Wien., 1953, 6: 59-65. Abstracted in: 

Excerpta med., Sect. T6, 1954, 2: No. 1702. 

1213 Klima, R. FORTSCHRITTE IN DER THERAPIE DER 

LEUKÃ„MIEN UND VERWANDTER ZUSTÃ„NDE. [ADVANCES 

IN THE TREATMENT OF LEUKEMIAS AND ALLIED CON 

DITIONS.] Wien. med. Wschr., 1953, 103: 347- 

350. Abstracted in: Leukemia Abstr., 1954, 

2: No. 735. 

1214 

Klimpf, L. W. ZUR CHEMOTHERAPIE MALIGNER TU 

MOREN. 

Klin., 

[CHEMOTHERAPY OF MALIGNANCIES.] Med. 

Beri., 1952, 47: 1196-1201. Approx. 

100 refs. 

1215 Knight, B. C. J. G. ESSENTIAL METABOLITES AND 

ANTI-METABOLITES. J. Mount Sinai Hosp., N. 

York, 1949, 15: 281-292. 

in: Excerpta~med., Sect. 


2, 1949, 2: No. 5746. 

1216 

KÃhler, H. ÃœBER ERFAHRUNGEN UND ERGEBNISSE 

MIT MITOSEHEMMENDEN MITTELN BEI MALIGNEN 

TUMOREN. [EXPERIENCE AND RESULTS OF TREAT 

MENT OF MALIGNANT TUMORS WITH 

HIBITORS.] Zbl. Chir., 1952, 

MITOTIC IN 

77: 865-874. 

3 refs. 

1217 Koppinghoff, K. H. CHEMOTHERAPEUTIKA IN DER 

KREBSBEHANDLUNG.Â¡CANCERCHEMOTHERAPY] . 

Garmisch-Partenkirchen, Fachliteratur- 

34 t. 

Ermittlungs- und Berichtsdienst fur Industrie 

und Forschung, 1951. 155 refs. Typewritten. 

1218 v 

KratochvÃl, M. MEDIKAMENTÃ“ZNA LIECBA RAKOVINY. 

[CHEMOTHERAPY OF CANCER.] Bratisl. lek. 

listy, 1948, 28; 783-794. 50 refs. A survey 

of chemotherapeutic drugs, chiefly extracts, 

AF2 'and the cytotoxic serum. 

1219 

Â«Kuhlmey, W. EL TRATAMIENTO MEDICAMENTOSO DEL 

CANCER. 

Medicina, 

[MEDICAL 

Madr., 

TREATMENT 

1954, 22: 

OF CANCER.] 

205-212. 

1220 Larionov, L. F. and Mankin, Z. V^ BIOLOGICHESKIE 

I KHIMICHESKIE SPOSOBY LECHENIIA RAKA. [BIO 

LOGICAL AND CLINICAL WAYS OF CANCER THERAPY.] 

In: Zlokachestvennye opukholi: Klinicheskoe 

rukovodstvo [Malignant tumors] (N. N. Petrov, 

ed.) Leningrad, Medgiz, 1948, 1: pt. 2, 117- 

152. 78 refs. A survey of cancer chemothera 

py. Serum, toxin and hormone therapy are em 

phasized; organic and inorganic chemotherapeu 

tic substances are also discussed. 

1221 

Latarjet, R. RECENTI DATI SULLA CHEMIOTERAPIA 

DEL CANCRO. [RECENT DATA ON CHEMOTHERAPY OF 

CANCER.] Omnia ther., Pisa, 1952, 3: 151- 

163. 

1222 

Leonard, J. and Wilkinson, J. F. THE ACUTE 

LEUKAEMIAS. In: Modern trends in blood 

diseases. (Wilkinson. J. F., ed). 

York, P. B. Hoeber, 1955, 247-262. 

New 

43 

refs. 

acute 

See especially, Chemotherapy in 

leukaemia, p. 254-361. Review, 

noting effective dosage and toxic effects. 

1223 

LettrÂ«, H. EXPERIMENTELLE GRUNDLAGEN DER CHEMO 

THERAPIE DER TUMOREN. [EXPERIMENTAL PRINCIPLES 

OF CANCER CHEMOTHERAPY.] Acta UniÃ³ internat. 

cancr., Louvain, 1953, 9: 757-759. 

1223a 

LettrÃ©, H. GRUNDLAGEN DER CHEMISCHEN TUMORBE 

HANDLUNG. 

THERAPY.] 

[FUNDAMENTALS OF CANCER CHEMO 

Med. Klin., Beri., 1954, 49: 1535- 

1538. 30 refs. 

1224 

LettrÃ©, H. NEUERE ERGEBNISSE DER EXPERIMENTELLEN 

KREBSFORSCHUNG. [RECENT RESULTS OF EXPERIMEN 

TAL CANCER RESEARCH.] Strahlentherapie, 1953, 

92: 5-18. 38 refs. 

1225 

LettrÃ©, H. DER STAND DER KREBSFORSCHUNG. [THE 

STATUS OF CANCER RESEARCH.] Medizinische, 

1953, 2: 897-908. Approx. 80 refs. Discussion 

and review of the nature of carcinogenic agents, 

the morphological and biochemical nature of 

malignancy, and the effects of chemicals on 

malignant growth.



73 

GENERAL 

& REVIEW (Continued) 

1226 

Lewisohn, R. CHEMOTHERAPEUTIC REGRESSIONS OF 

TRANSPLANTED AND SPONTANEOUS CANCERS IN MICE. 

I. REVIEW 

1937-1945. 

OF THE WORK OF THE 

In: APPROACHES TO 

LABORATORY, 

TUMOR CHEMO 

THERAPY. Was?., 

p. 139-147. 

Am. Ass. Advance. Sc., 1947 

1227 Le-Xuan-Cbat VALEURCOMPARÃ‰E DES REMEDESDE LA 

LEUCOSE AIGUÃ‹. [COMPARATIVEVALUEOF THE 

REMEDIES AGAINST ACUTE LEUKOSIS,] Hist, ned., 

Par., 1954, 4: No. 6, 89-96. Abstracted in: 


1228 

Loffi IT, W. and Bollag, W. LEUKXMIE PROBLEME. 

[LEUKEMIA 

8: 70-92. 

PROBLEMS.] 

21 refs. 

Oncologia, Basel, 1955, 

1229 

Magistris, H. NEUE CYTOSTATICA. [NEW CYTOSTATIC 

DRUGS]. Ã–sterr. Apoth. Ztg., 1954, 8: 215-216. 

5 refs. A survey of cytostatic drugs, chiefly 

urethane, colchicine and myleran. The latter 

is considered most effective which in daily 

doses of 4 mg has achieved remissions lasting 

up to 1 1 2 years. 

1230 

Magrassi, F. LO STATO ATTUALE DELLA TERAPIA 

MEDICA DELLE EMOPATIE MALIGNE. [THE PRE 

SENT STATE OF THERAPY OF MALIGNANT BLOOD 

DISEASES]. 

Â¿7: 315-331. 

Recenti progr. 

62 refs. 

med.,Roma, 1954, 

1231 Marinello, Z. TRATAMIENTO ACTUAL DE LAS HEMO- 

LINFOPATIAS TUMORALES. [MODERN TREATMENT OF 

TUMORAL HEMOLYMPHOPATHIESj. Arch, cuban, 

cancer., 1953, 12: 47-50. 

1232 

Marinone, G. LA CHIMIOTHÃ‰RAPIE DES KÃ‰MOPATHIES 

MALIGNES A L'AIDE DE SUBSTANCES MITO-INHIBÃ• - 

TRICES. [CHEMOTHERAPY OF MALIGNANT HEMOPA- 

THIES WITH MITOTIC INHIBITORS.] Rev. hemat., 

Par., 1953, 8: 438-461. 38 refs. 

1233 

Marmont, A. and Fusco, F. IL PROBLEMATERAPEUTICO 

DELLE LEUCEMIE ACUTE; TENTATIVI ED ESPERIENZE 

CLINICHE. [THE THERAPEUTIC PROBLEMOF ACUTE 

LEUKEMIA; EXPERIMENTALAND CLINICAL RESULTS.] 

344p. PavÃa. 1953. [Biblioteca haematologica, 

XIV.] 

1233a 

Marquardt, H. NEUERE ERGEBNISSE DER ZYTOLOGIE 

UND ZYTOGENETIK IN IHRER BEDEUTUNG FÃœR EINE 

GRUNDLAGENFORSCHUNG DER CHEMOTHERAPIE DER 

TUMOREN. [NEW FINDINGS IN CYTOLOGY AND CYTO- 

GENETICS IN THEIR RELATION TO THE BASIC STUDY 

OF THE CHEMOTHERAPY OF TUMORS.] Aerztl. 

Forsch., 1949, 2: Originalarb., 407-412. 29 

refs. 

1234 

Martin, E. LYMPHOGRANULOME, LYMPHOSARCOME ET 

RETÃ•CULOSARCÃ“ME; TRAITEMENT MÃ‰DICAL. [LYMPHO- 

GRANULOMA, LYMPHOSARCOHA AND RETICULOSARCOMA; 

MEDICAL TREATMENT.] 

1951, 20: 295-312. 

Radiol. 

Approx. 

clin., Basel, 

75 refs. A rÃ©vieÂ» 

au3 discussion of chemotherapeutic treat 

ment . 

1235 

Martini, P. ÃœBER DIE CHEMOTHERAPIE DES KREBSES. 

[CANCERCHEMOTHERAPY.] Beri. 

1950, 1: 165-171. 

raed. Zschr., 

1236 Maurice, p. LES LEUCOSESAIGUÃ‹SET CHRONIQUES 

DE L'ENFANCE ET DE L'ADOLESCENCE. [ACUTE 

AND CHRONIC LEUKEMIAOF CHILDREN AND ADOLES 

CENTS] . Acta paediat. belg., 1952, 6: 5-52. 

Bibliography: p. 49-52. See especially 

. P. 24-49 for chemotherapy. 

1237 Meythaler, F. and Handel, F. CHEMOTHERAPIE 

MALIGNERTUMOREN. [CHEMOTHERAPYOF MALIG 

NANTTUMORS.] Arzneimitt. 

2: 582-587. 52 refs. 

Forsch., 1952, 

1238 i .JO 

Mitchell, J. S. CHEMOTHERAPYOF CANCER. 

Practitioner, 1948, 160: 476-487. 57 refs. 

Spanish translation IÃ±T Jornada mÃ©d., B. Air., 

1949, 3: 141-150. 

1239 

Monnet, R. and Ruis, J. CHIMIOTHÃ‰RAPIE ANTI- 

CANCEREUSE. [CAMCERCHEMOTHERAPY.]Bull, 

alger, carcin., 1953, 6: 360-374. 43 refs. 

Review article. 

1240 

Morel, A. and Josserand, A. LES TROIS Ã‰LÃ‰MENTS 

CONSTITUANT LE FACTEUR INFLAMMATOIRE AU COURS 

DE L'EVOLUTION DES CANCER EPITHÃ‰LIAUX. DE 

DUCTIONS CONCERNANT LA THÃ‰RAPEUTIQUEANTI- 

INFLAMMATOIRE DES CANCERS. [THE THREE ELE 

MENTS Ã›T THE INFLAMMATORY FACTOR IN THE COURSE 

OF THE EVOLUTION OF EPITHELIAL CANCERS. 

DEDUCTIONS ON THE ANTIPHLOGISTIC 

CANCER.] J. mÃ©d. Lyon, 1951, 32: 

THERAPY OF 

59-63. 

1241 

Moure Conceiro, L. QUIMIOTERAPIA DEL CANCER. 

[CHEMOTHERAPYOF CANCER.] Galicia clin., 

Cornila, 1954, 26: 461-479. 

12Nagata, T. BASIC STUDIES ON CHEMOTHERAPYFOR 

CANCER (STUDIES ON THE YOSHIDA SARCOMA). 

Hoken igaku zassi, 1949, Â£7: No. 3, 1-12. 

In Japanese. 

1243 Neyses. D. ALLGEMEINBEHANDLUNG VON KREBSER 

KRANKUNGEN. [SYSTEMIC APPROACH IN CANCER 

THERAPY.] Medizinische, 1952, 2: 1299-1303. 

23 refs. 

1244 Norilrrisi.il, N. G. NAGRA SYNPUNKTER PÃ‚ LEUKEMI- 

BEHANDLING. Â¡CONSIDERATIONS ON LEUKEMIA 

TREATMENT.] Sven. lÃ¤k. tidn., 1955, 52: 

518-524. 

1245onat,A. R. L'OSEMILERIN TEDAVISIHAKKINDA. 

[TREATMENT OF LEUKEMIAS.] Turk tip cemiy. 

mecmuasi, 1953, 19: 33-51. Following a 

review of the literature of the treatment 

of leukemia, 4 cases of acute leukemia are 

reported. Aminopterin, ACTH and cortisone 

were administered but no remissions achieved. 

1245a 

Â«Osato, S. ON THE CHEMOTHERAPY OF CARCINOMA. 

II. Tohoku J. Exp. M., 1950, 52; 181-194. 

1246 

Â»Paterson, E. THE CHEMOTHERAPYOF MALIGNANT 

DISEASE. Practitioner, Lond., 1955, 174: 

279-288. 

1247 Perianes, J. LOS NUEVOS FÃ•RMACOS EN EL TRATA 

MIENTO DE LAS LEUCEMIAS. [NEW DRUGS IN THE 

TREATMENT OF LEUKEMIAS.] Rev. clin, espaÃ±., 

1952, 47: 118-128. Approx. 75 refs. 

1248 

Piemonte, M. CHEMIOTERAPIA E RADIOTERAPIA NELLA 

CURA DEI TUMORI MALIGNI. [CHEMOTHERAPY AND 

RADIOTHERAPY OF MALIGNANT TUMORS.] Rass. clin, 

se., 1953, 29: 107-113. Translated in: Resenha 

clin, cient., S. Paulo, 1954, 23: 3-10. A 

review article on the treatmenÃ¯~~ofcancer with 

colchicine, podophyllin, nitrogen mustard, triethylene 

melamine and urethane. 

1249 

Poncher, H. G., Waisman, H. A., Richmond, J. B., 

Horak, O. A. and Limarzi, L. R. TREATMENT 

OF ACUTE LEUKEMIA IN CHILDREN WITH AND WITHOUT 

FOLIC ACID ANTAGONIST. J. Pediat., S. Louis, 


Leukemia Abstr., 1953, 1^:No. 157. 

1250 

Ponthus, P. APERÃ‡UTHÃ‰RAPEUTIQUE SUR LA 

MALADIEDE HODGKIN. [THERAPYOF HODGKIN'S 

DISEASE.] Rev. mÃ©d.Moyen Orient., 1950, 

7: 424-441. 46 refs.



74 


1251 

Ramioul, H. LES APPLICATIONS CLINIQUES ACTUELLES 

DE LA CHIMIOTHÃ‰RAPIE ANTICANCÃ‰REUSE. [PRESENT 

CLINICAL APPLICATION 

THERAPY.] Rev. med. 

OF ANTICANCEROUS CHEMO 

Liege, 1951, 6: 758-770. 

48 refs. Review article covering Ã®he doses, 

action and effects of the following drugs: the 

nitrogen mustards, urethane, folie acid anta 

gonists, bacterial products and endocrine sub 

stances . 

1252 

Reeves, R. J., Boyd, J. A. and Jackson, M T. 

ADVANCES IN THE MANAGEMENT OF CHRONIC GRANULO- 

CYTIC LEUKEMIA; 

Carolina M. J., 

A REPORT OF 170 CASES. North 

1954, 15: 257-260. 4 refs. 

1253 

Reggiani, G. LA TERAPIA DELLE LEUCEMIE; I NUOVI 

FARMACI. [THERAPY OF LEUKEMIAS: NEW DRUGS.] 

Boll. Soc. med. chir. Cremona, 1947-1948, 2: 

79-86. 15 refs. Treatment with urethane,- 

nitrogen mustard are discussed. 

1254 

Reimann, S. P. ATTEMPTS AT THE CHEMOTHERAPY OF 

CANCER. N. Orleans M. & S. J., 1951, 103: 

464-469. 

1255 

Reimann, S. P. A REPORT ON MICROSCOPIC PRO 

GRESS IN THE CHEMOTHERAPY OF CANCER. Tr . 

Coll. Physicians, Philadelphia, 1953, 21: 

1-13. 

1256 

Reimann, S. P. and Nlshimura, E. T. THE EXPERI 

MENTAL BACKGROUND OF RECENT ATTEMPTS AT CHEMO 

THERAPY OF CANCER. Pennsylvania 

52: 832-836. 23 refs. 

M. J., 1949, 

1257 Reimer, E. E. and Vinazzer, H. DIE THERAPIE 

AKUT VERLAUFENDER LEUKOSEN. [THERAPY OF 

ACUTE 

1951, 

LUEKEMIA.] Wien. Zschr. 

32: 117-121. 44 refs. 

inn. Med., 

1258 

Reinhard, E. H., Good, J. T. and Martin, E. 

CHEMOTHERAPY OF MALIGNANT NEOPLASTIC DISEASES. 

J. Am. M. Ass., 1950, 142: 383-390. Discussion: 

p. 389-390. Abstractedâ€”tn:Chem. Abstr., 1950, 

44: 4139ÃŒ. 

1259 

Rentchnick, P. CHIMIOTHERAPIE DU CANCER. [CHEMO 

THERAPY OF CANCER.] 

10: 62-64. A review 

Med. & hyg., Geneva, 1952, 

of the following agents, 

giving method of administration, dosage, mecha 

nism of action, indication for treatment and 

results: urethane, nitrogen mustards, folie 

acid antagonists, 

and oligo-metals. 

radioactive isotopes, hormones 

1260 

Rerabek, J. CHEMOTHERAPIE RAKOVINY. [CHEMO 

THERAPY OF CANCER.] 

269-276. 54 refs. 

Cesk. farm., 1952, 1: 

1261 

Reyes, G. L. MANAGEMENT OF WHITE BLOOD CELL 

DISORDERS. J. Phillippine M. Ass.. 1952, 


Eeukemia Abstr., 1953, 1L:No. 194. Treat 

ment of leukemias with arsenic, benzol, 

X-ray, radioactive phosphorus, urethane, 

nitrogen mustard, triethylene melamine, 

folie acid antagonists and steroids is re 

viewed. 

1262 

Riegel, R. ERGEBNISSE UND AUSSICHTEN EINER 

CYTOSTATISCHEN THERAPIE BEI HAEMOBLASTOSEN 

UND MALIGNEN NEOPLASMEN. [RESULTS AND PROG 

NOSIS OF CYSTOSTATIC THERAPY IN HEMOBLASTO- 

SIS AND MALIGNANT NEOPLASMS.] Deut. med. J., 

1955, 6: 249-256. Approx. 30 refs. 

1263 

Rhoads, C. P. ADVANCES IN TREATMENT OF MALIG 

NANT DISEASE. 

25: 271-284. 

Bull. N. 

36 refs. 

York Acad. 

Abstracted 

M., 1949, 

in: Biol. 

Ã„Estr., Bait., 1949, 23: No. 15238. 

1264 

Rhoads, C. P. CANCER CHEMOTHERAPY. Rev. 

Gastroenter.. N. Y., 1952, 19: 217-225. 

This review is concerned witlr the prin 

ciple of selective injury of cancer cells 

in the search for new cancer chemotherapeutic 

agents. 

1265 

Rhoads, C. P. EXPERIMENTAL AND CLINICAL THERA 

PEUTIC STUDIES ON LYMPHOSARCOMA. 

M., 1948, 29: 811-821. 26 refs. 

Ann. Int. 

See p. 816- 

819 for chemotherapeutic agents. 

1266 

Rhoads, C. P. PRESENT STATUS OF CHEMOTHERAPY 

IN CANCER. N. York State J. M., 1954, 54: 

2557-2564. 12 refs. 

1267 

Rhoads, C. P. RATIONAL CANCER CHEMOTHERAPY. 

Science, 1954, 

survey devoted 

119: 77-80. 31 refs. A 

To"the concept of specific 

cancer chemotherapy. 

1268 

Rhoads, C. P. RECENT DEVELOPMENTS ON THE TREAT 

MENT OF CANCER. Chicago M. Soc. Bull., 

52: 893-898. This review is devoted to 

1950, 

the 

Basic principles of therapy rather than to 

the actual treatment. 

1269 

Rondoni, P. LA CHEMOTERAPIA DEI TUMORI. [THE 

CHEMOTHERAPY OF TUMORS.] 

1952, 67: 161-168. 

Accad. med., Tor., 

1270 

Rondoni, P. LA CHEMOTERAPIA DEI TUMORI MALIGNI. 

[THE CHEMOTHERAPY OF MALIGNANT TUMORS.] Farmaco, 

PavÃa, 1946, 1.:344-356. Approx. 75 refs. 

1271 

Rosenow, G. RECENT PROGRESS IN THE DIAGNOSIS 

AND TREATMENT OF BLOOD DYSCRASIAS. Proc. 

Rudolf Virchow M. Soc., N. York, 1951, 10: 

51-61. 

1272 

Ross, J. F. and Ebaugh, F. G. CURRENT TRENDS 

IN THE MANAGEMENT OF THE LEUKEMIAS AND THE 

MALIGNANT LYMPHOMAS. Med. Clin. N. America, 

1951, 35: 1381-1401. 27 refs. 

1273 

Rouillard, J. M...and Hauswald, R. TRAITEMENT DES 

LEUCÃ‰MIES AIGUÃ‹S. [TREATMENT OF ACUTE LEUKEMIA.! 

Strasbourg mÃ©d., 1953, 4: 659-666. 8 refs. 

1274 

Sampey, J. R. ANIMAL EXPERIMENTS WITH ANTICANCER 

AGENTS, 1952. Am. J. Pharm., 1954, 126: 326- 

335. 122 refs. 

1275 

Sampey, J. R. CLINICAL STUDIES ON ANTICANCER 

AGENTS FROM 1949 to 1951. Am. J. Surg., 

1954, 87: 877-882. 194 refs. 

1276 Sampey, J. R. CLINICAL STUDIES ON ANTI-CANCER 

AGENTS, 1952-1953. Internat. Ree. Med., 1954, 

167: 398-406, 438. 110 refs. 

1277 

Sampey, J. R. INHIBITING CANCER IN ANIMALS. V. 

(1949-1953). Am. J. Pharm., 1955, 127: 53-64. 

173 refs. 

1278 

SÃ¡nchez Medal, L. LA QUIMIOTERAPIA EN LOS PADE 

CIMIENTOS HEMATOLÃ“GICOS MALIGNOS. [CHEMO 

THERAPY OF MALIGNANT HEMATOLOGICAL DISEASES.] 

Gac. mÃ©d. MÃ©xico, 1953, 83: 443-451. 2 pi. 

23 refs. English .summary. 

1279 SÃ¡nchez Ruiz, M. TERAPÃ•UTICACLÃ•NICADE LAS 

LEUCEMIAS. [CLINICAL THERAPYOF LEUKEMIAS.] 

Sem. med., B. Air., 1948, 55: pt. 2, 417-426. 

62 refs.



75 


1280 Sarasin, R. and Dubois-FerriÃ¨re, H. POSSIBILITÃ‰S 

DE COMBINAISONS DE CHIMIOTHÃ‰RAPIE ET DE RADIO 

THÃ‰RAPIE. [POSSIBILITIES IN COMBINING CHEMOTHERA 

PY WITH RADIOTHERAPY.] Radiol. clin., Basel, 

1951, 20: 255-259. 

1281 

Shimkin, M. B. and Bierman, H. R. EXPERIMENTAL 

CHEMOTHERAPY OF NEOPLASTIC DISEASES. 

1949, 53: 518-529. 64 refs. Spanish 

Radiology, 

summary: 

p. 528=529. Abstracted in: Chem. Abstr., 1950, 

44: 

Ie~ukemia.-Urethane 

5006d. Contents: 

in 

Potassium 

leukemia.-Amine 

arsenite 

mustards 

in 

in lymphomas.-Bacillus prodigiosus polysaccharide 

in lymphoma and sarcoma.-Stilbamidine in 

multiple 

in acute 

myeloma., Pteroylglutamic 

leukemia.-Castration and 

derivatives 

estrogens in 

prostatic carcinoma. Estrogens and 

in mammary carcinoma.-Miscellaneous 

androgens 

agents.- 

Conclusion. 

1282 

Shimkin, M. B. CHEMOTHERAPEUTIC MANAGEMENT OF 

LYMPHOMAS; EFFECT UPON SURVIVAL. Harlem 

Hosp. Bull., N. Y,, 1955, 8: 62-78. 22 refs. 

A live-year study on the cEemotherapy of 221 

patients with neoplasms of the hemic and 

lymphatic systems. The chemical agents chiefly 

used were: nitrogen mustard, urethane, myleran, 

aminopterin, 

triethylene 

potassium arsenite, Stilbamidine, 

melamine and cortisone and corticotrophin. 

1282a 

Sirtori, C. LA TERAPIA MEDICA DEI TUMORI IN BASE 

ALLE RECENTI CONOSCENZE BIOLÃ“GICOS. [TUMOR 

THERAPY BASED ON RECENT BIOLOGICAL ACHIEVEMENTS. 

284p. Milano, Ambrosiana, 1953. Contains one 

chapter on chemotherapy of tumors, p. 119-139. 

The anti-cancer substances are tabulated by 

their formulas; morphological, biochemical and 

therapeutical effect and by dosage. 

1283 

Smith, R. H. TREATMENT OF LEUKEMIA AND SIMILAR 

DISORDERS. U.S. Armed Forces M. J., 1951, 2: 

1787-1794. 32 refs. 

1284 

Sokoloff, B. CANCER; NEW APPROACHES, NEW HOPE. 

243 p. New York, Devin-Adair, 1952. See 

especially: 

p. 106-125; 

Metabolic 

Bacterial 

approach in Cancer, 

toxins in cancer thera 

py, p. 126-148; Hodgkin's Disease, p. 149-158; 

Minerals in cancer treatment, p. 159-165. 

Notes and references, p. 202-224. 

1285 

Soldi, A. and Gialdi, F. LO STATO ATTUALE DELLA 

CHEMIOTERAPIA DEI TUMORI MALIGNI. [PRESENT 

STATE OF 

Farmaco, 

MALIGNANT CANCER CHEMOTHERAPY.] 

ed. se., Pavia, 1950, 5: 220-226. 

1286 

Soto Allande, R., Torregrosa, L. and Torroella, 

J. M. TRATAMIENTO DE LAS LEUCEMIAS EN PEDIA 

TRIA. [TREATMENT OF LEUKEMIA IN PEDIATRICS.] 

Bol. med. Hosp. inf., Mex., 1951, 8: 32-53. 


1287 

Â»STATO SITUALE DELLA CHEMIOTERAPIA DEL CANCRO. 

[PRESENT STATE OF CHEMOTHERAPY OF CANCER.] 

Clin, nuova, Roma, 1953, 16: 551-557. 

1288 

Stern, P. and Sprung, L. ÃœBER DIE PRÃœFUNG DER 

ANTILEUKAMISCHEN SUBSTANZEN AN DER HUHNER- 

LEUKOSE. [THE EFFECT OF ANTI-LEUKEMIA DRUGS 

ON CHICK LEUKOSIS.] Arch. Exp. Path., Beri., 

1953, 218: 100-101. Abstracted in: Leukemia 

Abstr.7~T953, l_:No. 345. 

1289 

Stickney, J. M. CHEMOTHERAPY OF THE LEUKEMIAS 

AND LYMPHOMAS. Minnesota M., 1954, 37: 275- 

277. A short review discussing the use of 

the 4-aminopteroyl glutamic acids , 6-mercaptopurine 

hormones, urethane, myleran and Fowler's 

solution. 

1290 

Stock, C. C. ASPECTS OF APPROACHES IN EXPERI 

MENTAL CANCER CHEMOTHERAPY. 

1950, 8: 658-674. 82 refs. 

Am. J. Med., 

1291 

Stock, C. C. EXPERIMENTAL CANCER CHEMOTHERAPY. 

Advance. Cancer Res., 1954, 2: 425-492. 

Bibliography: p. 478-492. A~review covering 

the postwar years. 

1292 

Â«Sykes, M. P. TECHNIQUES EMPLOYED IN EXPERI 

MENTAL CANCER CHEMOTHERAPY. J. Am. 

Ass., 1954. 8: 103-108. Abstracted 

M. Women 

in: 

Excerpta mod., Sect. 16, 1955, 3: No. 899. 

Ã®agnon, H. CHIMIOTHERAPIE DU CANCER; RECHERCHES 

ET ESPOIRS ACTUELS. [CHEMOTHERAPY OF CANCER; 

CURRENT RESEARCH AND HOPES.] Ann. Soc. SO. 

mÃ©d. natur. Bruxelles, 1954, 7: 139-151. 

TÃ“szeghi, A. UJABB GYÃ“GYITÃ“ELJÃ•RÃ•SOKA HAE- 

MATOLOGIABAN. [NEW THERAPEUTIC METHODS IN 

HEMATOLOGY.] Orv. lapja, 1948, 4: No. 23; 

750-755. 50 refs. The literature on drugs 

used in hematology is reviewed. Folie acid, 

nitrogen mustard, urethane, Stilbamidine and 

penicillin among others are discussed in de 

tail. 

1295 TREATMENT OF LEUKEMIA. N. York State J. M., 

1952, 52; 2910-2918. A Cornell conference 

on therapy. 

1296 

Truhaut, R. PRINCIPALES TENDANCES ACTUELLES 

DE LA CHIMIOTHÃ‰RAPIE ANTICANCÃ‰REUSE. [PRE 

SENT PRINCIPAL TRENDS IN CHEMOTHERAPY OF 

CANCER.] Produits pharm., 1955, 10: 365-374. 

Review dealing with the chemistry~biological 

action and therapeutic application of many 

compounds, among which, apart from hormones, 

are colchiclne, urethane, nitrogen mustards, 

TEM, myleran, aminopterin, amethopterin, 

mercaptopurine, actinomycin and azaserine. 

12Truhaut, R. QUELQUES ASPECTS ACTUELS DES RE 

CHERCHES SUR LE CANCER AUX Ã‰TAS-UNIS. 

FPRESENT STATUS OF CANCER RESEARCH IN THE 

UNITED 

4l: 129-148. 

STATES.] 

Bibliography:"p. 

Biol. mÃ©d., Par., 

147-148. 

1952, 

Short.r version of this paper in: Produits 

pharm., 1952, 7: 121-126. 

1298 

Truhaut, R. QUELQUES RÃ‰SULTATS RÃ‰CENTS DES 

RECHERCHES SUR LA CHIMIOTHÃ‰RAPIE DES Ã‰TATS 

CANCEREUX AUX ETATS-UNIS. [RECENT RESULTS 

OF RESEARCH ON CANCER CHEMOTHERAPY IN THE 

UNITED STATES.] Gaz. med. France, 1951, 

Spec. No. 139-144. 11 refs. 

1299 

Truhaut, R. TENDANCES ACTUELLES DES RECHERCHES 

DE CHIMIOTHERAPIE DES Ã‰TATS CANCÃ‰REUX. [RE 

VIEW OF CANCER CHEMOTHERAPY.] Actual pharm., 

1952, 5: 213-270. Bibliography: p. 256-270. 

The foTlowing agents are reviewed: organ ex 

tracts, amino acids, choline, vitamins, hor 

mones, colchicine, 

urethane, nitrogen 

podophyllin, arsenides, 

mustards, and their disulphonic 

esters, bis-epoxides, TEM, phosphoramides, 

antagonists of folie acid and pyridoxine, 

diamidines, aminopterin. purine anta 

gonists, bacterial toxins, antibiotics, and 

various other compounds. 

1300 

Udupa, K. N. PRESENT STATUS OF CHEMOTHERAPY 

IN CERTAIN MALIGNANT DISEASES. 

Madras, 1952, 49: 126-132. 

Antiseptic, 

1301 Vannotti, A. APROPOS DU TRAITEMENT DES LEUCÃ‰ 

MIES. [TREATMENT OF LEUKEMIA.] Helvet. med. 

acta, 1947, 14: 475-480.




VÂ«nnotti, A. TENDANCES ACTUELLES DANS LE DIAG 

NOSTIC ET LA THERAPIE DITCANCER. [PRESENT 

TRENDS IN THE DIAGNOSIS AND TREATMENT OF 

CANCER.] Oncologia, Basel, 1953, 6: 102-117. 

17 reÃs. Therapy based on reversing biologi 

cal and chemical changes specific for cancer 

cells appears to have promising results. 

Action of hormones, radioactive isotopes, 

radiomimetic agents, mitotic inhibitors and 

antimetabolites is discussed. 

Veldstra, H. PROBLEMEN EN MIDDELEN BU DE 

CHEMOTHERAPIE VAN ONTAARDE GROEI. [PROBLEMS 

AND METHODS OF CHEMOTHERAPY OF MALIGNANT 

NEOPLASMS.] Geneesk. gids, 1951, 29: 81-96. 


Â»Vermeil, Â£.M. METODIKA ISSLEDOVANIÃ•A, PRIMENfA- â€ž¿ 

EMAÃ•A V EXPERIMENTAL'NOI KHIMIOTERAPII OPUKHOLEI. 

[RESEARCH APPLIED IN EXPERIMENTAL CANCER CHEMO 

THERAPY.] Sovrem. probi, onkol., ser. A, 1949, 

No. 1, 12-17. A survey of research methods 

used in experimental chemotherapy conducted in 

non-Russian countries and reviewed mostly in 

Western literature. Experimental animals, types 

of experimental tumors, in vitro and vivo results 

of cancerolytic agents are discussed. 

13Vermel', E. M. OSNOVNYE PUTÃŒ I NAPRAVLENIÃŒÃ€V 

KHIMIOTERAPI I OPUKHOLEI. [BASIC PATHS AND 

DIRECTIONS OF CANCER CHEMOTHERAPY.] Sovrem. 

probi, onkol., ser. A, 1949, No. 1, 6-11. 

A survey of anti-cancer drugs, chiefly colchicine, 

nitrogen mustard, folie acid and 

anti-reticular cytotoxic serum. The report 

is based on trends in non-Russian mainly 

Western literature. 

13Slchsmuth, R. VIER JAHRE KREBSTHERAPIE 1945- 

1948. [FOUR YEARS OF CANCER THERAPY 1945- 

1948.] Ther. Gegenwart, 1949, 218-222; 251- 

257. 176 refs. 

13Watkins, C. H. EVALUATION OF THERAPEUTIC AGENTS 

IN RECENT USE IN THE CONTROL OF EXPERIMENTAL 

AND HUMAN LEUKEMIA. Proc. Inst. M. Chicago, 

1946-1947, 16: 386 392. 

13WatkinS, C. H. TREATMENT OF LEUKEMIA. Wisconsin 

M. J., 1949, 48: 239-242. 11 refs. Essentially 

the same as: PYoc. Inst. M., Chicago, 1947, 16: 

386 392. 

13Â°Whitby,L. LEUKAEMIA. II. TREATMENT. Brit. 

M. J., 1951, No. 4747, 1573-1575. 

^Wilkinson, J. F. DISCUSSION ON THE CHEMOTHERAPY 

OF THE RETICULOSES. Proc. R. Soc. M., Lond., 



13Wintrobe, M. M. CURRENT VIEWS CONCERNING THE 

NATURE AND MANAGEMENT OF LEUKEMIA AND ALLIED 

DISORDERS. Proc. Inst. M. Chicago, 1949, 

17: 318-328. 33 refs. French translation 

TÃ±: Rev. himat., Par., 1949, 4: 593-604. 

1312 Wintrobe, M. M., Cartwright, G. E., Fessas, P., 

Haut. A. and Altman, S. J. CHEMOTHERAPYOF 

LEUKEMIA, HODGKIN'S DISEASE ANDRELATEDDIS 

ORDERS. Ann. Int. M., 1954, 41: 447-464. 

tab. 27 refs. 

13Woglom, W. H. GENERALREVIEWOF CANCERTHERAPY. 

In: APPROACHESTO TUMORCHEMOTHERAPY. Wash., 

Xm. Ass. Advance. Sc., 1947, p. 1-12 Dis 

cussion: p. 10-12; Bibliography: p. 8-10. 

Wright, J. C. CHEMOTHERAPYOF HUMANCANCER. 

Tr. N. York Acad. Sc., 1955, ser. 2, 17: 

210-236. 97 refs. 

1314Â« 

Vaniamolo, F. THEORETICAL CONSIDERATIONS ON 

THE CHEMOTHERAPY OF CANCER. Gann, Tokyo, 

1953, 44: 365-366. In Japanese. 

1315 ZÃŒS8U,R. LE TRAITEMENTOFFICIEL DU CANCER. 

[OFFICIAL THERAPYOF CANCER.] Homoeopath. 

fr., 1951, 27: 514-543. 

See 

182 

1643 

2672 

3467 

GLIOTOXIN 

see also 

424 

1811 

2928 

3583 

FUNGI 

684 

2011 

2960 

3607 

1500 

2024 

3115 

1515 

2142 

3458 

1316 

Mason, J. W. and Kidd, J. G. EFFECTS OF GLIO 

TOXIN AND OTHER SULFUR-CONTAINING COMPOUNDS 

ON TUMOR CELLS IN VITRO. WITH OBSERVATIONS 

ON THE MECHANISM OF ACTION OF GLIOTOXIN. 

J. Immun., 1951, 66: 99-106. 4 refs. 

Abstracted in: BiÃT. Abstr., Bait., 1951, 

25: No. 20444. 

See 

1064 2711 

GLUCAMINE, 

N-METHYL- 

Layani, F. and Aschkenasy, A. LEUCEMIE MYÃ‰LOÃ•DE 

ATYPIQUE AVEC SYNDROME HUMORAL DE MYELOME ET. 

LESIONS OSSEUSES PAGETOÃ•DES. MYELOSE OU MYELO- 

SARCOMATOSE? EFFET DES EXSANGUINO-TRANSFUSIONS 

ET D'UN TRAITEMENT PAR LES SELS D tANTIMOINE. 

[ATYPICAL MYELOID LEUKEMIA WITH HUMORAL SYN 

DROME OF MYELOMA AND PAGETOID BONE LESIONS. 

MYELOSIS OR MYELOSARCOMATOSIS? EFFECT OF EX- 

SANGUINATION TRANSFUSIONS AND OF A TREATMENT 

WITH ANTIMONY SALTS.] Bull. Soc. med. hop. 

Paris, 1948, 64: 1140-1148. 1 rÃ©f. 

GLUCOASCORBIC 

ACID 

1318 

Sokoloff, B., Eddy, W. H., Powella, R., Beaumont, 

J. and ReÃos, H. ASCORBIC ACID ANALOG IN EX 

PERIMENTAL CANCER. Cancer Res., 1953, 13. 639- 

645. 32 refs. Abstracted in: Excerpta mÃ©d., 

Sect. 16, 1954, 2: No. 1176. Continuous 

feeding during 4~weeks of a nontoxic dietary 

level (1 and 2 per cent) of D-gluco-ascorbic 

acid considerably retarded Crocker rat car 

cinoma and mouse adenocarcinoma Eo771. 

1319 Sokoloff, B.. Eddy, W. H., Powella, R., Beaumont, 

J. and ReÃos, H. ASCORBIC ACID ANALOG IN EX 

PERIMENTAL LEUKEMIA. Cancer Res., 1954, 14: 

307-310. 17 refs. 

GLUCOSAMINE 

1320 Marlow, A.A. and Bartlett, G. R. GLUCOSAMINE 

AND LEUKEMIA. Proc. Soc. Exp. Biol., N. Y., 

1953, 8_4: 41-43. 

See 

137



77 

GLUCOSAMENE, D_ 

1321 

LettrÃ©, H. ZUR FRAGE EINER TUMORHEMMENDEN 

WIRKUNG DES GLUCOSAHINS. [A TUMOR-INHIBI- 

TING EFFECT OF GLUCOSAIIINE.] Naturwissen 

schaften, 1953, 40: 513. 5 reis. A tumorinhibiting 

effecl~of glucosamine could not 

be confirmed on either mouse ascites tumor 

or on various types of sarcoma. 

1322 

Â«Penhos, J. C. INHIBICIÃ“N DEL CRECIMIENTO DE 

TUMORES POR LA D-GLUCOSAMINA. [INHIBITION 

OF TUMOR GROWTH BY D-GLUCOSAMINE.] Cienc. 

b invest., B. Air., 1953, 9: 272-273. 

1323 Quastel, J. H. and Cantero, A. INHIBITION OF 

TUHOR GROWTH BY D-GLUCOSAMINE. Nature, Lond., 


Chem. Ã®Bstr., 1953, 47! 4508f. 

1324 

Rubin, A., Springer, G. F. and Hogue, M. J. THE 

EFFECT OF D-GLUCOSAMINE HYDROCHLORIDE AND RE 

LATED COMPOUNDS ON TISSUE CULTURES OF THE SOLID 

FORM OF MOUSE 

14: 456-458. 

SARCOMA 37. Cancer Res., 

pi. 12 refs. Abstracted 

1954, 

in: 


1325 

SEARCH FOR TUMOUR INHIBITORS. Lancet, Lond., 

1953, 1: 429. 4 refs. 

GLUCOSE 

SM 

1055 

D-GLUCOSE, 

2-DESOXY- 

1326 Ely, J. 0. 2-DEOXY-D-GLUCOSE AS AN INHIBITOR 

OF CANCEROUS GROWTH IN ANIMALS. J. Franklin 

Inst., 1954, 258: 157-160. 5 refs. Adminis 

tration of 2DG to mice inhibited to a con 

siderable extent the growth of Krebs ascites 

carcinoma and to a lesser degree the growth 

of two subcutaneousLy grafted tumors but did 

not retard the course of myelogenic leukemia. 

1327 

Â«Woodward, G. E. and Cramer, T. B. 2-DESOXY-D- 

GLUCOSE AS AN INHIBITOR OF ANAEROBIC GLYCOLY- 

SIS IN TUMOR TISSUE. 

254: 259-260. 

J. Franklin Inst., 1952, 

1328 

Woodward, G. E. and Hudson, M. T. THE EFFECT 

OF 2-DESOXY-D-GLUCOSE ON GLYCOLYSIS AND RES 

PIRATION OF TUMOR AND NORMAL TISSUES. 

Cancer Res., 1954, 14; 599-605. 9 refs. 

64 

GLUCURONIC ACID 

1328Â» 

Wright, A. W. and Delchmann, W. B. EFFECT OF 

GLUCURONIC ACID ON BENZYPYRENE-INDUCED SKIN 


365-367. 

Cancer Res., 1955, Suppl. No. 2, 

GLUCURONIDE, 

CYANOGENETIC 

1329 

Guidetti. H. OBSERVATIONSPRELIMINAIRES SUR 

QUELQUESCAS DE CANCERTRAITES PAR UN GLY- 

CURONOSIDECYANOGENETIQUE. [PRELIMINARY 

OBSERVATIONSOF SEVERALCASES OF CANCER 

TREATED WITH A CYANOGENETICGLUCORONISIDE.] 

Acta UniÃ³ internat, cancr., Lsuvain, 1955, 

11: 156-158. 18 refs. "...thÃ© destructive 

action of the glucuroniside was very definite 

GLUTAMIC ACID, 4-AMINO-9, NlO-DI-METHYLPTEROYL- 

1330 

Wolff, R. and Karlin, R. SUR LE MÃ‰CANISME 

D'ACTION ANTIBACTÃ‰RIENNE D'UN DÃ‰RIVÃ‰DE L'ACIDE 

FOLIQUE DOUÃ‰ D'UN POUVOIR ANTILEUCÃ‰MIQUE. [ME 

CHANISM OF ANTIBACTERIAL ACTION OF A FOLIC ACID 

DERIVATIVE WITH ANTILEUKEMIC ACTIVITY.] 

Soc. biol., 1950, 144: 567-569. 5 refs. 

C. rend. 

"4- 

amino-9, 10-dimethyl pteroylglutamic acid is 

a microbial growth inhibitor and is active as 

folie acid antagonist. The mode of action was 

studied. It has no influence 

of thymine and vitamin 6^2. " 

on the action 

1354 1355 

GLUTAMIC ACID, 4-AMINO-9-METHYLPTEROYL- 

1331 

Sawitsky, A., Ritz, N. D., Jacobson, J., Meyer, 

L. M., Schwartz, S. O., Krim, M., Bock, G. 

and 

MIA 

Brahin, C. M. TREATMENT OF ACUTE LEUKE 

WITH ANTI-FOLIC ACID COMPOUNDS (ANINO- 

PTERIN AND AMINOANFOL). Cancer, Phila., 1952, 

5: 344-353. 12 refs. 

See 

1354 1355 1583 

GLUTAMIC ACID, 4-AMINO-N10-METHYLPTEROYL-, 


1332 

Burchenal, J. H., Biedler, J. L., Nutting, J. 

and Stobbe, G. D. THE EFFECTS OF 4-AMINOâ€ž¿iO-METHYL 

PTEROYLGLUTAMICACID ON THE LEU 

KOCYTESOF THE NORMALAND LEUKKMICHOUSE. 



3: No. 3587. 

1333~ 

Ãºurchenal, J. H., Webber, L. F., Meigs, G. M. 

and Biedler, J. L....A COMPARISON OF THE EF 

FECTS OF 4-AMINO-N10-METHYL-PTEROYLGLUTAMIC 

ACID AND 2,6-DIAMINOPURINE UPON SENSITIVE 

AND RESISTANT SUBLINES OF A STRAIN OF MOUSE 

LEUKEMIA. Blood, Bait., 1951, 6: 337-343. 

28 refs. Abstracted in: Biol. Abstr., Bait., 

1951, 25: No. 33789; Exaerpta med., Sect. 

5, 19527 5: No. 464. 

1334 Moore, A. E., Stock, C. C., Suglura, K. and 

Rhoads, C. P. INHIBITION OF DEVELOPMENT 

OF SARCOMA 180 BY 4-AMIÂ»O-N10-METHYL PTEROYL 

GLUTAMIC ACID. Proc. Soc. Exp. Biol., N.Y., 

1949, 70: 396-398. 4 refs. Amethopterin 

administered intraperitoneally in concentra 

tions of 1.5 Bg kg per day for 7 days inhi 

bited the growth of transplanted mouse Sar 

coma 180. Few mice died from drug toxicity. 

The compound is most effective when admin 

istered early in development of tumor. 

See 

141 320 742 1359 1371 

1373 1375 1379 1391 1429 

2887 EFFECT 2971 ON NORMAL 3141 GROWTH 3362 

See 

1353 EFFECT 1362 ON TUMOR1399 GROWTH1633 

IN PLANTS 

â€”¿ 

1335 

De Ropp, R. S. SOME NEW PLANT-GROWTH INHIBITORS. 

Science, 1950. 112: 500-501. 5 refs. The 

inhibiting actioTT~of 57 different compounds 

on the growth of healthy and of tumor plants 

was studied and compared.



78 

GLUTAinC ACID, 4-AMINO-N10-METHYLPTEROYL -, 

â€”¿ EFFECTS, COUNTERACTION TO 

1336 

Burchenal, J. H., Babcock, G. H., Broquist, H. P. 

and Jukes, 

EFFECTS OF 

T. H. PREVENTION OF CHEMOTHERAPEUTIC 

4-AMINO-NlO-UETHYL-PTEROYLGLUTAMIC 

ACID ON HOUSE LEUKEMIA 

Proc. Soc. Exp. Biol., 

BY CITROVOHUM FACTOR. 

N. Y., 1950, 74: 735- 

737. 1 pi. Abstracted In: Excerpta ned., 

Sect. 5, 1951, 4: No. 1409; Chen. Abstr., 1950, 

44: 10158e. 

1337 Burchi.nal, J. H., Kushida, M. N., Johnston, S. F. 

and Cremer, M. 

PEUTIC EFFECTS 

A. 

OF 

PREVENTION OF CHEMOTHERA 

4-AMINO-NlO-METHYLPTEROYL- 

GLUTAHIC ACID ON MOUSE LEUKEMIA BY PTEROYL- 

GLUTAMIC ACID. Proc. Soc. Exp. Biol., N. Y., 


Chem. Bait., ATjstr., 1951, 25j 1949, No.~3~3788. 43: 9186Ã•; Biol. Abstr., 

1338 Law, L. W. and Boyle, P. J. RESPONSE OF A RE 

SISTANT VARIANT OF LEUKEMIC CELLS TO AN AN 

TAGONIST OF PTEROYLGLUTAMIC ACID. Proc. 

Soc. Exp. Biol., N. Y., 1951, 77: 340-344. 

14 refs. Abstracted in: Biol.~Sbstr., Bait., 

1951, 25: No. 36123. 

1339 

Skipper, H. E., Bell, tf. and Thomson, J. R. 

PARTIAL REVERSAL 

OF A-KETHOPTERIN 

OF THE ANTILEUKEMIC ACTIVITY 

BY CORTISONE. Cancer Res., 

1954, 14: 86-87. 3 refs. 

1340 Skipper, H. E., Nolan, C., Newton, M. A. and 

Simpson, L. THE EFFECT OF FOLIC 

A METHOPTERIN-INDUCED INHIBITION 

ACID ON 

OF NUCLEIC 

ACID 

370. 

SYNTHESIS. Cancer Res., 1952, 12: 369- 

9 refs. "Using Cl4-formate incÃVporation 

as a means of measuring the rate of 

synthesis of nucleic acids, it has been 

demonstrated that the inhibition of nucleic 

acid synthesis induced by A methopterin 

be partially reversed by folie acid.". 

can 

See 

1442 

EFFECTS, ENHANCEMENT OF 

1341 

Law, L. 1. EFFECTS OF COMBINATIONS OF ANTI 

LEUKEMIC AGENTS ON AN ACUTE LYMPHOCYTIC 

LEUKEMIA OF MICE. Cancer Res., 1952, 13: 

871-878. 

See 

2971 


PROCESSES) 

1342 Anlyan, A. J. ft -GLUCUHONIDASESTUDIES IN STEM- 

CELL LEUKEMIAS. Cancer, Phila., 1954, 7: 391- 

393. rÃ©f. Abstracted in: Leukemia Abslr., 

1954, 2: No. 712. 

1.343 

Burchenal, J. H., Waring, G. B., Ellison, R. R. 

and Reilly, H. C. A SIMPLE METHOD FOR DETER 

MINATION OF LEVELS OF AMETHOPTERIN IN BLOOD 

AND URINE. Proc. Soc. Exp. Biol., N. Y., 

1951 78: 603-608. This report on a method 

includes" data on blood and urine levels of 

aBethopterin. 

Fountain, J. R., Waring, G. B., Hutchison, D. J. 

and Burchenal, J. H. DISTRIBUTION OF AME 

THOPTERIN IN NORMAL MOUSE TISSUES FOLLOWING 

INTRAVENOUS INJECTION. Proc. Soc. Exp. Biol., 

N. Y., 1952, 81: 193-196. Abstracted in: 

Leukemia AbstrT, 1953, 1: No. 15. 

1345 

Skipper, H. E., Bennett, L. L., Jr. and Law, 

L. W. EFFECTS OF A-METHOPTSRIN ON FORMATE 

INCORPORATION INTO THE NUCLEIC ACIDS OF 

SUSCEPTIBLE AND RESISTANT LEUKEMIC CELLS. 


"...A-methopterin inhibits formate incorpo 

ration into nucleic acid purines and thymine 

in leukemic cells which are sensitive 

to this compound and also in viscera of 

mice bearing these susceptible leukemic 

cells. A-methopterin, however, causes a 

significant increase in formate incorpora 

tion into the nucleic acids of leukemic 

cells which have become dependent on A 

methopterin for optimal growth while inhi 

biting formate incorporation in the vis 

ceral nucleic acids of mice bearing the 

dependent strain of leukemia." 

1346 Skipper, H. E., Mitchell, J. H., Jr. and Bennett, 

L. L., Jr. INHIBITION OF NUCLEIC ACID SYN 

THESIS BY FOLIC ACID ANTAGONISTS. Cancer 

1950, 10: 510-512. 13 i-efs. Aminopterin 

Res., 

and 

A-methopterin inhibited the incorporation of 

Cl4 from formate into nucleic acids and nu 

cleic acid purines. The compounds partially 

blocked the incorporation of C140ii into purines 

but did not block tissue CO2 fixation. 

1347 

Skipper, H. E., Morgan, C. and Bennett, L. L., 

Jr. EFFECTS OF A-METHOPTERIN (4-AMINO-NlO- 

METHYLPTEROYLGLUTAMIC 

OF THE ADEKINE MOIETY 

ACID) ON THE 

OF ADENOSINE 

SYNTHESIS 

TRIPHOS- 

PHATE. Cancer Res., 1952, 12: 413-414. 

8 refs. 

1348 

Skipper, H. E., Thomson, J. R. and Bell, M. 

ATTEMPTS AT DUAL BLOCKING OF BIOCHEMICAL 

EVENTS IN CANCER CHEMOTHERAPY. 

1954, 1Â£: 503-507. 15 refs. 


1349 

Williams, A. D., Winzler, R. J. and Law, L. W. 

THE EFFECTS OF A-METHOPTERIN ON THE IN-VITRO 

INCORPORATION OF P32(>4 INTO NORMAL AND LEU 

KEMIC MOUSE TISSUES. 

135-138. 31 refs. 

Cancer Res.. 1954, 14: 

See 

1340 1460 1461 


1350 Ferguson, F. C., Jr. EFFECTS OF 4-AMINO-N1"- â€ž¿10 

METHYLPTEROYLGLUTAMIC ACID ON THE EXTRA 

CELLULAR FLUIDS OF RATS. Proc. Soc. Exp. 

Biol., N. Y., 1951. 77: 259-262. Abstracted 

in: Chem. Abstr., 19ST, 45: 8137g. 

1351 Wright, J. C. EFFECT OF FOLIC ACID ANTAGONIST, 

A-METHOPTERIN, ON THE LEVEL OF THE CIRCULATING 

EOSINOPHILS IN HUMANS. Blood, Bait., 1952, 

7: 743-748. 18 refs. 

1957 

RESISTANCE TO 

1352 Burchenal, J. H., Robinson, E., Johnston, S. F. 

and Kushida, M. N. THE INDUCTION OF RESIS 

TANCE TO 4-AMINO-NlO-HÂ£THYL-PTEROYLGLUTAMIC 

ACID IN A STRAIN OF TRANSMITTEDMOUSELEUKE 

MIA. Science, 1950, 111: 116-117. 7 refs. 

Abstracted in: Chem. JbÃ¯tr., 1950, 44: 6014e. 

1353 Kieler, J. and Kieler, E. THE EFFECT OF A- 

METHOPTERIN ON SENSITIVE AND RESISTANT LEU 

KEMIC CELLS IN VITRO. Cancer Res., 1954, 

14: 428-432. 19 refs. 

13taw. L. W. and Boyle, P. J. DEVELOPMENT OF RE 

SISTANCE TO FOLIC ACID ANTAGONISTS IN A TRANS- 

PLANTABLE LYMPHOID LEUKEMIA. Proc. Soc. Exp. 

Biol., N. Y., 1950, 74: 599-602. 10 refs.



79 

GLUTAIOC ACID, 4-AM3NO-N10-METHYLPTEHOYL-, 

â€”¿ RESISTANCE TO (Continued) 

1355 

Nichol, C. A. STUDIES OF THE MECHANISM OF RE 

SISTANCE TO FOLIC ACID ANTAGONISTS BY LEU- 

KEMIC CELLS. Cancer Res., 1954. 14: 522- 

526. 29 reÃs. 

1356 

NiChol, C. A. and Welch, A. D. METABOLIC RE 

QUIREMENTS FOR FORMATION OF CITROVORUM FAC 

TOR AND STUDIES OF MECHANISM OF RESISTANCE 

TO A-METHOPTERIN. In: Antlmetabolites and 

cancer. (Rhoads, C. P., ed.) Washington, 

Am. Ass. Advanc. Sc., 1955, 63-87. Biblio 

graphy: p. 85-87. 

1357 

Pillers, E. M. K., Burchenal, J. H., Eliel, L. P. 

and Pearson, 0. H. RESISTANCE TO CORTICOTROPIN, 

CORTISONE, AND FOLIC ACID ANTAGONISTS IN LEU 

KEMIA. J. Am. M. Ass., 1952, 148: 987-994. 

9 reis. 

1358 

Skipper, H. E. and Burchenal, J. H. THE NUCLEIC 

ACID INHIBITING ACTION OF 4-AMINO-N10-METHYL- 

PTEROYLGLUTAMIC ACID IN MICE WITH A SENSITIVE 

AND RESISTANT STRAIN OF LEUKEMIA. Cancer Res. 

1951, 11: 229-231. 14 refs. "Nucleic acid 

synthesTs in the livers and spleens of mice 

bearing a refractory strain of leukemia was 

not inhibited to the same extent by A-methopterin 

as was observed in mice with a leukemic strain 

which responds to treatment with this compound." 

See 

131 3522 

TOXICITY 

1359 

Bennette, J. G. AMETHOPTERIN: A TOXIC TUMOUR 

GROWTH INHIBITOR. Brit. 

6: 377-388. 21 refs. 

J. Cancer, 1952, 

1360 Burchenal, J. H. and Babcock, G. M. PREVENTION 

OF TOXICITY OF MASSIVE DOSES OF 4-AMINO-NlO- 

METHYLPTEROYLGLUTAMIC ACID (A-METHOPTERIN) 

BY CITROVORUM FACTOR. Proc. Soc. Exp. Bini., 


in: Chem. AbsÃ®F., 1951, 45: 62941 and 6295a. 

1361 

Ferguson, F. C., Thiersch, J. B. and Philips, 

F. S. THE ACTION OF 4-AMINO-NlO-METHYL- 

PTEROYLGLUTAMIC 

J. Pharm. Exp. 

ACID IN MICE, RATS AND DOGS. 

Ther., 1950, 98: 293-299. 

5 refs. Abstracted in: Excerpta mod., Sect. 

cation 2, 1950, and* 3: the No. lesions 5859. produced The coursebyof4-amino- 

intoxi 

See 

NlO-methyl-pteroylglutamic acid were similar 

to those produced by 4-amino-pteroylglutamic 

acid, but the N10-methyl analog was only 

l/10th as toxic as the 4-amino-pteroylglu 

tamic acid. 

1365 1570 1598 1603 

TOXICITY, COUNTERACTION TO 

1362 

Franklin, A. L., Belt, M., Stokstad, E. L. R. 

and .Ink,â€”., T. H. BIOLOGICAL STUDIES WITH 

4-AMINO-lO-METHYLPTEROYL-GLUTAMICACID. 


See 

1429 THERAPY1598 

1625 

1363 

Dacie, J. V., Dresner, E., Mollin, D. L. and 

White, J. C. ACUTE LEUKAEMIA TREATED WITH 

'A-METHOPTERIN'. Brit. M. J., 1951, 1: 

784-792. 26 refs. 

1364 

Greenspan, E. M. SOME THEORETICAL AND PRACTICAL 

ASPECTS OF THE USE OF FOLIC ACID ANTAGONISTS 

IN HUMAN NEOPLASIA. J. Mount Sinai Hosp 

N. York, 1952, 19: 583-595. pi. 34 refs. 

1365 

Meyer, L. M. and Rutzky, J. AN UNUSUAL CASE 

OF ACUTE PLASMA-CELL LEUKEMIA TREATED WITH 

A FOLIC ACID ANTAGONIST AND URETHANE. 

Cancer, N. Y., 1951, 4: 1043-1051. 3 pi. 

16 refs. 

1366 

Meyer, L. M., Miller, F. R.. Rowen. M. J.. Bock, 

G. and Rutzky, J. TREATMENT OF ACUTE LEUKEMIA 

WITH AMETHOPTERIN(4-AMINO, 10-METHYL PTEROYL 

GUFTAMIC ACID). Acta 

4: 157-167. 11 refs. 

haemat., Basel, 1950, 

"Three of eleven cases 

of acute leukemia showed clinical improvement 

following administration of amethopterln, 

two of these in patients with monocytic leu 

kemia and one in the lymphoid variety. In the 

latter instance relief of bone pain and sub 

sidence of temperature were the most conspi 

cuous findings. The blood picture remained 

leukemic in all instances. In all eleven 

patients some toxic manifestation of drug 

therapy was generally severe enough to necessi 

tate cessation of drug therapy. Toxicity and 

beneficial effects were not related to dose, 

age or sex. Clinical improvement occurred in 

two patients with monocytic leukemia, a type 

generally regarded 

acid therapy." 

as resistant to anti-folic 

1367 Vignolo-Lutati, U. LINFOSARCOM DEL LATTANTE 

TRATTATO CON ACIDO N-4 (2 AMINO-4-IDROSSI- 

PTERIDIL-6 METILAMINO) BENZOILGLUTAMICO. 

[LYMPHOSARCOMA IN AN INFANT, TREATED WITH 

N-4 (2-AMINO-4-HYDROXYPTERIDYL-6-METHYLAMINO) 

BENZOYLGLUTAMIC ACID.] Minerva med., Tor., 


med., Sect. 7, 1951, 5: No. 1359. 

See 

143 

1494 

1518 

1567 

2903 

1035 

1495 

1536 

1574 

2969 

1295 

1498 

1541 

1581 

1488 

1505 

1542 

1583 

GLUTAMIC ACID, 4-AMINOPTEROYl._ 

1493 

1514 

1561 

1644 

1368 

Dresner, E. and White, J. C. THE BIOLOGICAL 

ACTION AND CLINICAL APPLICATION OF FOLIC 

ACID ANTAGONISTS; REVIEW. Acta haematol., 

Basel, 1952, 7: 117-127. 8 refs. 

1369 

Â»AMINOPTERIN. Nord, med., 1955, 53: 211-212. 

EFFECT 


1370 

Asano, T. STUDIES ON INHIBITING EFFECT OF 

AMINOPTERIN AND OTHER FOLIC ACID ANTAGONISTS, 

AND FOLIC ACID 

Toboku J. Exp. 


M., 1953, 57: 221-225. 2 refs. 

In English. 15 compounds were tested; only 

aminopterin had an inhibitory effect. 

1371 

Bessis, M. and Freixa, P. ACTION DE DEUX ANTA 

GONISTES DE L'ACIDE FOLIQUE SUR LA LEUCEMIE 

DES POULES. [ACTION OF TWO ANTAGONISTS OF 

FOLIC ACID ON FOWL LEUKEMIA.] C. rend. Soc. 

biol., Par., 1950, 144: 885-887. Abstracted 

in: Chem. Abstr., 1Ã•55T,45: 1659h. 

1372 

Bilek, O. KVANTITATIVNÃ• PUSOBENÃ• PTERINU NA 

BÃ•LY KREVNÃ•OBRAZ. [QUANTITAVE EFFECT OF 

PTERINS ON THE LEUCOCYTE COUNT.] Lek. listy, 

Brno, 1954, 9: 348-352. English summary.



80 

GLUTAMIC ACID, 4-AMINOPTEROYL-, 

ON MALIGNANT GROWTH (Continued) 


1373 Burchenal J. H , Burchenal, J. R., Kushida, 

SU-LUU . M . N. , 

Johnston, S. F. and Williams, B. S. STUDIA- STUDIES 

ON THE CHEMOTHERAPY OF LEUKEMIA. II. THE EFFECT 

OF 4-AMINO-PTEROYLGLUTAMIC ACID AND 4-AMINO Nlu 

METHYLPTEROYLGLUTAMIC ACID ON TRANSPLANTED 

MOUSE LEUKEMIA. Cancer, N. Y., 1949, 2: 113-118. 


43: No. 5505Ã•; Biol. Abstr., Bait., 1949, 23: 

Ho-. 23825. 

1374 

Goldin, A., Mantel, N., Greenhouse, S. W., 

Venditti, J. M. and Humphreys, S. R. ESTI 

MATION OF THE ANTILEUKEMIC POTENCY OF THE 

ANTIMETABOLITE AMINOPTERIN, ADMINISTERED 

ALONE AND IN COMBINATION WITH CITROVORUM 

FACTOR OR FOLIC ACID. 

13: 843-850. 17 refs. 

Cancer Res., 1953, 

1375 Goldin, A., Venditti, J. M., Humphreys, S. R., 

Dennis, D.. Mantel, N. and Greenhouse, S. W. 

A QUANTITATIVE COMPARISON OF THE ANTILEUKE 

MIC EFFECTIVENESS OF TWO FOLIC ACID ANTAGO 

NISTS IN MICE. J. Nat. Cancer Inst., 1955, 

15: 1657-1664. 12 refs. 

13oSnz, F. W. THE EFFECT OF 4-AMINO-PTEROYLGLU 

TAMIC ACID (AMINOPTERIN) ON HUMAN LEUKEMIC 

LEUKOCYTES IN VITRO. Blood, Bait., 1950, 


Ã¯ed., Sect. 2, 1950, 3: No. 5211. "...pro 

duced a marked inhibition of mitosis in low 

concentrations. Attempts to counter its action 

by means of folie acid gave varying results. 

The mechanism of the observed effect is dis 

cussed." 

1377 Isaacs, R. and Trimmer, R. W. BLOOD CELL 

CHANGES IN LEUKEMIA DURING AMINOPTERIN 

THERAPY. Ann. Int. M., 1951, 35: 236- 

239. 1 rÃ©f. Abstracted in: BIJTL. Abstr., 

Bait., 1951, 25: No. 33809. "After the 

use of aminopterin...large metamyelocytes 

and cells having characteristics Â»fmegaloblasts 

appeared in the bone marrow. 

These characteristics of the pernicious 

anemia type of blood and bone marrow pic 

ture appeared tÂ«be associated with the 

neutralization of the folie acid effect." 

13Johnson, E. P. THE EFFECT OF 4-AMINOPTEROYL- 

GLUTAMIC ACID (AMINOPTERIN), A FOLIC ACID 

ANTAGONIST ON EXPERIMENTALLY PRODUCED AVIAN 

LEUKOSIS. Vet. Med., 1951, 46: 312-314. 

9 refs. 

13K9irschbaum, A 

-isse^ 

Ã•N&Ã•STS ON TRANSPLANTED 

PHOID LEUKEMIAS OF THE F STRAIN OF MICE 

Cancer Res., 1950, 10: 762-768 15 refs. 


2-i- No 20440: Chem. Abstr., 1951, 45. 

5534b.' The influence of amethopterTE and 

methopterin was tested. 

13Law, L. W., Dunn, T. B., Boyle, P. J. and Miller, 

J H. OBSERVATIONS ON THE EFFECT OF A FOLIC 

ACID ANTAGONIST (AMfflOPTERIN) ON TRANSPLANTABLE 

LYMPHOID LEUKEMIAS IN MICE. J. Nat. Cancer 

Inst 1949, 10: 179-192. 2 pi. 27 refs. 

1381 Little, P. A., Sampath, A., Pagnelli, V., Locke, 

i.andsubbarow. Y. 'THE'KFFECT OFFOLÃ•C ACID 

AM) ITS ANTAGONÃ•STS ON ROUS CHICKEN SARCOMA. 

Tr. N. York Acad. Sc., 1947-1948, 10: 91-98. 

4 reÃÂ». "...Bous chicken sarcoma Eas been 

completely prevented by maintaining the birds 

on a synthetic, folie acid free diet froÂ» the 

time of inoculation with virus. BÂ»by chicks 

were found to be more satisfactory for this 

demonstration than adult birds since the re 

sults were 100 per cent. Rous chicken sar 

coma was also prevented by treating the birds 

with antagonists of folie acid (4-amino-folic 

acid, 4-amino-folic acid with d(-) glutamic 

acid, and 4-amino-pteroylaspartic acid). 

When treatment was delayed to permit suffi 

cient development of cells, these antagonists 

of folio acid were able to prevent further 

growth of the sarcoma." 

1382 

Â«Oleson, J. J. STUDIES ON PTEROYLGLUTAMICACID 

INHIBITORS. Tr. N. York Acad. Sc., 1950, 12: 

118-121. Abstracted in: Excerpta med., SecT. 

2, 1950, 3: No. 5858. 

1383 Ringsted, J. THE GROWTH OF ROUS SARCOMA IN CHICKS 

TREATED WITH AMINOPTERIN. Acta path, microb. 

scand., 1952, 31: 275-280. 8 refs. Abstracted 

in: Chem. Abstrr, 1952, 46: 9189d. 

1384 Sakurai, Y. and Yoshino, K. STUDIES ON CANCERO- 

CIDAL SUBSTANCES. I. EFFECT OF PTERINS ON 

THE YOSHIDA SARCOMA. J. Pharm. Soc. Japan, 

1952, 72: 1294-1296. 6 refs. In English. 

1385 

Schoenbach, E. B., Goldin, A., Goldberg, B. 

and Ortega, L. G. THE EFFECT OF FOLIC-ACID 

DERIVATIVES ON SARCOMA 180. Cancer, N. 

1949, 2: 57-64. 24 refs. Aminopterin, 

Y., 

when 

given Intravenously, intraperitoneally or 

subcutaneously retarded the growth of trans 

planted sarcoma 180 and altered the histology 

of the tumor. Teropterin and diopterin had 

no effect. 

13Schoenbach, E. B., Weissman, N., Goldberg, B. 

and Fisher, J. NUCLEIC ACID CHANGES IN SARCOMA 

180 FOLLOWING ADMINISTRATION OF AMINOPTERIN. 


562. 7 refs. The chief alteration in sar 

coma 180 tumors of mice treated with aminopterin, 

was an increase in the ratio of 

pentosenucleic to desoxypentosenucleic acid 

due to a relative reduction in the latter. 

When tumors, which had been serially trans 

planted into aminopterin treated mice, were 

used as inocula, they did not differ from 

stock tumors in their subsequent response 

to aminopterin. 

1387 Skipper, H. E., Edwards, P. C., Bryan, C. E., 

Chapman, J. B., Bell, M. and Hutchison, 0. S. 

STUDIES ON THE ANTILEUKEMIC ACTION OF CER 

TAIN COMPOUNDS RELATED 

4-AMINOPTEROYLGLUTAMIC 

TO MOIETIES OF THE 

ACID (AMINOPTERIN) 

MOLECULE. Cancer, N. Y., 1950, 3: 348-353. 

9 refs. 

1388 Spigliati, P. and Galardeschi, O. CONTRIBUTO 

ALLO STUDIO DELLE INTERFERENZE FRA LE AMINO- 

PTERINE E ACIDO FOLINICO SU I PROCESSI MA 

TURATIVI DELLE CELLULE LEUCEMICHE. [STUDIES 

ON INTERFERENCE OF AMINOPTERIN AND FOLIC ACID 

WITH PROCESS OF MATURATION OF LEUKEMIC CELL.] 

Biv. crlt. clin, med., 1952, 52: 287-292. 

8 refs. 

13KB Stern, P. and Sprung, L. UNE TEST-MÃ‰THODE DES 

SUBSTANCES ANTILEUECÃ‰MIQUES, UTILISANT LA 

LEUCOSE PROVOQUEE CHEZ LA POULE. [TESTING 

ANTI-LEUKEMIC SUBSTANCES IN EXPERIMENTAL LEU 

KEMIA IN CHICKEN.] Acta med. iugosl., 1953, 

7: 1-10. 2 refs. 

1390 Stickney, J. M., Hagedorn, A.B., Mills, S. D. 

and Cooper, T. 

MARROW IN ACUTE 

CHANGES IN BLOOD 

LEUCEMIA INDUCED 

AND BONE 

BY AMINO- 

PraiN. J. Laborat. Clin. M., 1948, 33: 

1481.



81 

GLUTAMIC ACID, 4-AMDÃOPTEROYL-, â€”¿ EFFECT 


1391 

Stock, C. C., Blesele, J. J., Burchenal, J. H., 

Karnofsky, D. A., Moore, A. E. and Sugiura, 

K. FOLIC ACID ANALOGS AND EXPERIMENTAL TU 

MORS. Ann. 

1360-1378. 

N. York Acad. 

32 reÃs. 

Sc., 1950, 52: 

1392 Sugiura, K., Uoore, A. E. and stock, C. C. 

TEE EFFECT OF AMINOPTERIN ON THE GROWTH OF 

CARCINOMA, 

Cancer, N. 

SARCOMA. AND 

Y., 1949, 2: 

MELANOMA 

491-502. 

IN ANIMALS. 

33 refs. 


3: No. 1491; Biol. Abstr., Bait., 1949, 23: 

No. 21214. 

See 

925 1050 1480 1648 3362 


1393 

Albrecht, H. and Boll, I. DIE EINWIRKUNG VON 

AMINOPTERIN AUF MENSCHLICHES KNOCHENMARK IN 

VITRO. [THE EFFECT OF AMINOPTERIN ON HUMAN 

BONE MARROW IN VITRO] Zschr. Krebsforsch., 

1951, 57: 496-500. 24 refs. 

1-10 mg/'lOOml aminopterin to 

Addition of 

bone marrow 

cultures decreased the mitotic index by 33%. 

No specific effect on any cell type of the 

bone marrow was observed. 

1394 

BÃ©nard, H., Rambert, P. and Dantchev, D. ACTION 

DE L'AMINOPTÃ‰RINE SUR L'HÃ‰MATOPOIÃˆSE DU RAT. 

[EFFECT OF AMINOPTERIN ON HEMOPOIESIS 

RAT.] Sang, Par., 1953, 2Â£: 364-371. 

IN THE 

Rats 

weighing from 150 to 250 g were injected subcutaneously 

with 1/30 to 1/50 mg of amino 

pterin daily or every 2 days. The drug pro 

duced grave aplastic anemia and acted upon 

the erythroblasts which became pathologic 

and showed megaloblastic tendencies. 

1395 

Boll, I. and Schlag, H. UNTERSUCHUNGEN ÃœBER 

DIE EINWIRKUNG VON TEROPTERIN UND AMINOPTERIN 

AUF MENSCHLICHES KNOCHENMARK IN VITRO. [IN 

VITRO STUDIES OF THE EFFECT OF TEROPTERIN AND 

AMINOPTERIN ON HUMAN BONE MARROW.] Zschr. 


Abstracted in: Chem.~Sbstr., 1952, 46: No. 

46811. 

1396 

Brendler, H. EFFECT OF A FOLIC ACID ANTAGONIST 

ON HORMONALLY INDUCED CHANGES IN THE 

STATE. Science. 1949, 110: 119-120. 

RAT PRO 

2 refs. 

Abstracted in: Â¿hem. AbsTF., 1949, 43: 8508Ã•. 

1397 

Conte-Marotta, R. and Miller, F. R. EFFECT OF 

AMINOPTERIN ON ANIMALS RECEIVING HYELOKENTRIC 

OR LYMPHOKENTRIC ACID. Prue. Soc. Exp. Biol., 


Chen. Abstr. ,~T951, 45: 2097b. 

1398 

Dubois-FerriÃ¨re, H. LEUCÃ‰MIE AIGUÃ‹ ET ANTA 

GONISTES DE L'ACIDE FOLiqUE. [ACUTE LEUKEMIA 

AND FOLIC ACID ANTAGONISTS.] Sang, Par., 

1950, 21: 372-375. Discussion: p. 374. 6 

refs. ~R"abbits were given intramuscular in 

jections of 12 mg. of aminopterin over a 

period of 18 days. Except for a slight 

anemia and leucopenia no change was evident 

in the medullary hematopoiesis. In a terminal 

case of acute leukemia 5 mg. of aminopterin 

caused depression in the number of leucocytes 

from 50.000 to 4.800. 

1399 

Dustin, P., Jr. ACTION DE DEUX ANTAGONISTES 

DE L'ACIDE FOLIQUE SUR LES MITOSES INTESTINALES 

DE LA SOURIS. [EFFECT OF TWO FOLIC ACID ANTA 

GONISTS ON INTESTINAL MITOSES IN MICE.] 

C. rend. Soc. biol., 1949, 143: 1609-1610. 


44: No. 9561g. 

1400 

Dustin, P., Jr. SUR LES LESIONS NUCLEAIRES ET 

CHROMOSOMIQUES PROVOQUÃ‰ES CHEZ LA SOURIS PAR 

LES ACIDES DIAMINO-PTEROYL-GLUTAMIQUES ET 

PAR LA DIAMINOPURINE. [CHROMOSOMAL AND NU 

CLEAR LESIONS INDUCED IN MICE BY DIAMINO 

DERIVATIVES OF FOLIC ACID AND BY DIAMINOPURINE.] 

C. rend. Soc. biol., 1950, 144: 1297-1299. 

4 refs. Abstracted in: Chem. Abstr., 1951, 45: 

No. 5730g. 

1401 

Goldsmith, E. D., Schreiber, S. S. and Nigrelli, 

R. F. AMINOPTERIN AND RESPONSE OF FROG OVI 

DUCTS TO ESTRADIOL. II. HISTOLOGICAL STUDIES 

AND MITOTIC COUNTS. Proc. Soc. Exp. Biol., 

N. Y., 1949, 7_l:461-463. 10 refs. 

1402 

Â»Goldsmith, E. D., Schreiber, S. S. and Nigrelli, 

R. F. 4-AMINOPTEROYLGLUTAMICACID(AMINOPTERIN), 

PTEROYLGLUTAMIC(FOLIO ACID, AND RESPONSE OF 

FROGS(RANACLAMITANS) TO ESTROGENS. Proc. Soc. 

Exp. Biol., N. Y., 1948, 69: 299-301. Abstracted 

in: Chem. Abstr., 1949, 43T 1474Ã•. 

1403 

Goldsmith, E. D., Schreiber, S. S. and Nigrelli, 

R. F. FOLIC ACID ANALOGS IN LOWER ANIMALS. 

II. THE AMPHIBIA: RANA CLAMITANS. Ann. N. 

York Acad. Sc., 1950, 52; 1346-1348. 11 refs. 

1404 

Â«Gubner, H. THERAPEUTIC SUPPRESSION OF TISSUE 

REACTIVITY. I. COMPARISON OF THE EFFECTS 

OF CORTISONE AND AMINOPTERIN. 

1951, 221: 169-175. 

Am. J. M. Sc., 

1405 

Karnofsky, D. A., Patterson, P. A. and Ridgway, 

L. P. EFFECT OF FOLIC ACID, "4-AMINO" FOLIC 

ACIDS AND RELATED SUBSTANCES ON GROWTH OF 

CHICK 

1949, 

EMBRYO. Proc. Soc. Exp. 

71.: 447-452. 17 refs. 

Biol., N. Y., 

1406 

Kimbel, K. H. ÃœBERDIE BEEINFLUSSUNG DES WEISSEN 

BLUTBILDES DURCH DIE PTEROYLGLUTAMINSAURE 

(FOLSÃ„URE). [THE EFFECT OF AMINOPTEROYL GLU 

TAMIC ACID ON THE LEUCOCYTIC BLOOD PICTURE.] 


1407 

Lewis. J. T., Rabasa, S. L. and Domenico, A. D. 

EFECTOS DE UNA DOSIS UNICA DE ACIDO 4-AMINO- 

PTEROILGLUTAMICO(AMINOPTERIN)EN LA RATA 

BLANCA. [THE EFFECT OF ONE SINGLE DOSE OF 

4-AMINO-PTEROYL GLUTAMIC ACID (AMINOPTERIN) 

ON THE WHITE RAT.] Rev. Soc. argent, biol., 


Blood clfangesresulting from a single intraperitoneal 

injection of 4-amino-pteroylglutamic 

acid in normal and adrenalectomized 

rats are described. 

[1408notused] 

1409 

Mustakallio, K. K. and TelkkÃ¤,A. EFFECT OF 

AUREOMYCIN, VITAMIN B12, FOLIC ACID AND AMINO 

PTERIN ON THE METAMORPHOSIS OF TADPOLES. 

Ann. med. exp. biol. fenn., 1954, 32: 9-14. 


49: 524d. 

1410 

Nanetti, L. INFLUENZA DELL"AMINOPTERINA SULLA 

RIGENERAZIONE EPATICA. [EFFECT OF AMINOPTERIN 

ON HEPATIC REGENERATION.) Boll. Soc. ital. 

Aminopterin 

biol. sper., 

inhibits~hepatic 

1954, 30: 927-930. 

regeneration. 

5 refs. 

1411 

Â»Pebley, E. M. TISSUE CHANGES FOLLOWING THE 

ADMINISTRATION OF AMINOPTERIN. 

City, 1949. (Thesis-Univ., M. 

351. 

Sc.) 

Kansas 

Type 

written. Unpublished.



82 

GLUTAJOC ACID, 4-AMINOPTEROYL-, 

ON NORMAL GROWTH (Continued) 


1412 

Penhos, J. C. MODIFICACIONES POR EL ACIDO 

FÃ“LICO O LA AMINOPTERINA DE LA ACCIÃ“N DE 

LAS HORMONAS SEXUALES EN EL SAPO. 

FICATION INDUCED BY FOLIC ACID AND 

[MODI 

BY AMINO- 

PTERIN ON 

Rev. Soc. 

THE ACTION OF SEX HORMONES IN TOAD.] 

argent, biol., 1953, 29: 200-203. 

10 rets. English summary. PropTonate of 

testosterone produced an increase in the weight 

of the testes and development of digital cal 

losity of the prepuberal toad. This effect was 

strengthened by folie acid but inhibited by 

aminopterin. Aminopterin also inhibited the 

stimulating action of estradiol. benzoate on 

the oviduct of the prepuberal toad. 

1413 Penhos, J. C. MODIFICATION PAR L'ACIDE FOLIQUE 

OU L'AMINOPTERINE DE L'ACTION DES HORMONES 

SEXUELLES CHEZ LE CRAPAUD. [CHANGES INDUCED 

BY FOLIC ACID OR AMINOPTERIN IN THE ACTION OF 

SEX HORMONES IN FROGS.] C. rend. Soc. biol., 

1954, 148: 921. 

1414 

Sansone, G. and Zunin, C. EMBRIOPATIE SPERI 

MENTALI DA SOMMINISTRAZIONE DI ANTIFOLICI. 

[EXPERIMENTAL EMBRYOPATHY CAUSED BY FOLIC 

ACID ANTAGONISTS.] Acta vitaminol., Milano, 

1954, 8: 73-79. 16 reÃs. English summary. 

Anomalies resulting from 4-amino-pteroylglutamic 

acid administration to pregnant rats 

are discussed. 

Schoenbach, E. B., Goldin. A. and Greenspan, 

E. M. STUDIES ON THE MECHANISM OF ACTION OF 

CHEMOTHERAPEUTIC AGENTS IN CANCER. III. RE 

LATIONSHIP OF GENITAL GROWTH RESPONSE IN MICE 

TO THE FOLIC ACID ANALOGUE, 4-AMINOPTEROYL- 

GLUTAMIC ACID. Cancer, N. Y., 1950, 3: 864- 

870. 9 refs. 

1416 

Silver, M. THE ROLE OF FOLIC ACID IN HORMONALLY 

INDUCED TISSUE GROWTH. J. Endocr., 1954, 10: 

95-110. pi. 46 refs. 

1417 

Thiersch, J. B. and Philips, F. S. EFFECT OF 

4-AMINO-PTEROYLGLUTAMIC ACID (AMINOPTERIN) 

ON EARLY PREGNANCY. Proc. Soc. Exp. Biol., 

N. Y., 1950, 74: 204-208. 4 refs. "4-aminopteroylglutamÃ¯c" 

acid was found to be lethal 

to the early embryos of mice and rats. Fetal 

death was observed with doses which temporari 

ly caused depletion of the bone marrow but 

no other significant symptoms in the mothers." 

1418 

Thiersch, J. B. and Philips, F. S. EFFECTS OF 

4-AMINO-PTEROYL-GLUTAMIC ACID IN DOGS WITH 

SPECIAL REFERENCE TO MEGALOBLASTOSIS. Proc. 

SOC. Exp. Biol., N.Y.. 1949, 71: 484-490. 


43l 8057e. 

1419 Tittler, I. A. and Belsky, M. M. PTEROYLGLU- 

TAMIC ACID ACTIVITY OF AMINOPTERIN IN TETRA- 

HYMENA GELEII. Science, 1951, 114: 493. 

I4Traina, V. EFFECTS OF AMINOPTERIN ON MALE SEX 

ORGANS OF GUINEA PIG. Nature, Lond., 1950, 

166: 310. 9 refs. 

14Ve"lardo, J. T. and Hisaw, F. L. INHIBITORY 

EFFECTS OF AMINOPTERIN ON DECIDUAL DEVELOP 

MENT. Am. J. Physiol., 1953, 172: 535-540. 

tab. 20 refs. Abstracted in:~Cfiem. Abstr., 

1953, 47: 6557Ã•. 

1422 

Waeley P. F. and Morgan, H. R. OBSERVATIONS 

ON THE EFFECTS OF FOLIC ACID ANTAGONISTS, 

FOLIC ACID, LIVER EXTRACT AND VITAMIN Bl2 ON 

EMBRYONATEO EGGS. Bull. Johns Hopkins Hosp., 

1948, 83: 275-278. tab. 2 refs. Abstracted 

in: Excerpta med., Sect. 2, 1949, 2: No. 3467; 

Chem. Abstr., 1948, 42: 89061. 

1423 

Waisman, H. A. and Harvey, R. A. RADIOLOGICAL 

EVIDENCE OF GROWTH IN CHILDREN WITH ACUTE 

LEUKEMIA TREATED 

Radiology, 1954, 

WITH FOLIC 

62: 61-64. 


5 refs. Abstrac 

ted in: Excerpta med., Sect. 16, 1954, 2: 

No. 3172; Leukemia Abstr., 1954, 2: No. 605. 

1424 

Harrow, M. X., Hisaw, F. L. and Salhanick, H. A. 

DIFFERENTIAL EFFECT OF AMINOPTERIN ON THE 

ACTION OF ESTRADIOL 

Am. J. Obst., 1954, 

AND PROGESTERONE IN 

6J7: 1139-1147. 

MONKEYS. 

See 

837 

1679 

1472 

2865 

1475 

2961 

1594 1653 

EFFECT ON TUMOK GROWTH IN PLANTS 

1425 Manli, P. and Straszewska, Z. ACTION DE L'AMINO 

PTERINE (ACIDE 4-AMINO-PTEROYLGLUTAMIQUE) SUR 

LES TUMEURS DU CROWN-GALL. [ACTION OF AMINO 

PTERIN (4-AMINOPTEROYLGLUTAMIC ACID) ON CROWN- 

GALL TUMORS.] Rev. belge path., 1952, 22: 

96-99. 1 rÃ©f. 


Â»Broquist, H. P., Brockman, J. A., Jr., Fahrenbach, 

M. J., Stokstad, E. L. R. and Jukes, T. H. 

COMPARATIVE BIOLOGICAL ACTIVITY OF LEUCOVORIN 

AND PTEROYLGLUTAMIC ACID. J. Nutrit., 1952, 

47^: 93-103. 

1427 Broquist, H. P., Stokstad, E. L. R. and Jukes, 

T. H. SOME BIOLOGICAL AND CHEMICAL PROPER 

TIES OF THE CITROVORUM FACTOR. J. Biol. 

Chem., 1950, 185; 399-409. 16 refs. 

1428 Candeias. J. A. N. INIBICAO DO PODER TOXICO 

DAS SUBSTÃ‚NICAS ANTAGONISTAS DO Ã€CIDO FÃ“LICO. 

[INHIBITION OF THE TOXIC POWER OF FOLIC ACID 

ANTAGONISTS.] Rev. clin., S. Paulo, 1951, 

27: 11-2. 8 refs. 

1429 

Chubb, L. G. and Laursen, A. L. FURTHER OBSER 

VATIONS ON THE EFFECT OF AMINOPTERIN, A-METHOP- 

TERIN AND CITROVORUM FACTOR ON THE GROWTH OF 

TRANSPLANTABLE AVIAN LYMPHOID TUMORS. Brit. 

J. Pharm., 1954, 9: 419-422. 12 refs. 

1430 

Cravens, W. W. and Snell, E. E. REVERSAL OF 

AMINOPTERIN INHIBITION IN THE CHICK EMBRYO 

WITH THE LEUCONOSTOC CITROVORUM FACTOR. 



Abstr., 1951, 45: 725c. 

1431 Dittmar, C. DIE WIRKUNG VON FOLINSAURE- 

ANTAGONISTEN UND VON GUANAZOLO AUF DAS 

WACHSTUM VON TUMOREN. [THE EFFECT OF 

FOLIC ACID ANTAGONISTS AND GUANAZOLO ON 

TUMOR GROWTH.] Zschr. Krebsforsch., 


in: Excerpta med., Sect. 5, 1952, 5: 

No. 1554. 

1432 

Evans, I. E. and Robson, J. M. THE REVERSAL OF 

OESTROGEN-AMINOPTERIN INHIBITION IN MICE. 

J. Endocr., Lond., 1955, 12: VII-VIII. 4 refs. 

1433 

Franklin, A. L., Stokstad, E. L. R. and Jukes, 

T. H. OBSERVATIONS ON THE EFFECT OF 4-AMINO 

PTEROYLGLUTAMIC ACID ON MICE. Proc. Soc. 


Abstracted in: Excerpta mÃ«H., Sect. 2, 1949, 

2: No.136; Chem. Abstr., 1948, 42: 50901.



83 

GLUTAMC ACID, 4-AMJNOPTEROYL-, â€”¿ EFFECTS 

COUNTERACTION TO 

1434 

Franklin, A. I,., Stokstad, E. L. R., Hoffmann, 

C. 

OF 

Â£., Belt, 

GROWTH OF 

M. and Jukes, T. 

ESCHERICHIA COLI 

H. 

BY 

INHIBITION 

4-AMINO- 

PTEROYLGLUTAMIC 

Am. Chem. Soc., 

ACID AND ITS REVERSAL. J. 

1949, 71: 3549-3550. 12 refs. 

1435 

Goldin, A., Goldberg, B., Ortega, L. G. and 

Schoenbach. E. B. REVERSAL OF AMINOPTERIN- 

INDUCED INHIBITION OF SARCOMA 180 BY FOLIC 

ACID. Cancer, N. Y., 1949, 2: 857-862. 

9 refa. Abstracted in: Biol. Abstr., Bait., 

1950, 24: No. 4092. Aminopterin-induced 

inhibition of the growth of sarcoma 180 was 

partially reversed by folie acid. 

1436 Goldsmith, E. D. and Harnly, H. H. REVERSAL 

OF THE ACTION OF A FOLIC ACID ANTAGONIST, 

4-AMINOPTEROYLGLUTAMIC ACID, IN DROSOPHILA 

1IELANOGASTER. Cancer Res., 1950, 10: 220. 

1437 

Jacobson, W. THE FUNCTION OF THE LEUCONOSTOC 

CITROVORUM FACTOR IN CELL DIVISION AND THE 

INACTIVATION OF AMINOPTERIN. J. Physiol., 

Lond., 1954, 123: 618-632. 

1438 

Kline, I. T. and Dorfman, R. I. CITROVORUM FAC 

TOR AND OVIDUCT RESPONSE TO STILBESTROL 

AMINOPTERIN-TREATED CHICKS. Proc. Soc. 

IN 

Exp. 

Biol., N. T., 1951, 76: 203-205. 17 refs. 

1439 

Naber, E. C., Snell, E. E. and Cravens, W. W. 

EFFECT OF NUCLEIC ACID DERIVATIVES IN THE 

REVERSAL OF AMINOPTERIN INHIBITION IN THE 

CHICK EMBRYO. Proc. Soc. Exp. Biol., N. Y., 

1952, fn: 20-22. 13 refs. 

1440 

REVERSAL OF AMINOPTERIN 

Rev., 1951, 9: 12-14. 

INHIBITION. 

A review. 

Nutrii. 

1441 

Rodney, G., Swendseid, M. E. and Swanson, A. L. 

THE ROLE OF PTEROYLGLUTAMIC ACID IN TYROSINE 

OXIDATION BY RAT LIVER TISSUE. J. Biol. 

Chem., 1949, 179; 19-24. 14 refs. 

1442 

Skipper, H. Â£., Chapman, J. B. and Bell, M. 

PARTIAL REVERSAL OF THE ANTILEUKEMIC ACTION 

OF FOLIC ACID ANTAGONISTS BY VITAMIN Bl2. 

Cancer Res., 1951, 11: 161-163. 12 reis. 


25: No. 27918. "A consistent but small rÃ© 

duction in the efficacy of two folie acid 

antagonists in the treatment of Ak 4 leu 

kemia in mice 

administration 

was 

of 

observed following 

vitamin 812." 

the 

1443 Skipper, H. E., Chapman, J. B. and Bell, M. 

STUDIES ON THE ROLE OF FOLIC ACID IN THE 

LEUKEMIC PROCESS. Cancer, N. Y., 1950, 



Chem. Abstr., 1950, 44: lOSSldT 

1444 

Snell, E. E. and Cravens, W. W. REVERSAL OF 

AMINOPTERIN INHIBITION IN THE CHICK EMBRYO 

WITH DESOXYRIBOSIDES. Proc. Soc. 

N. Y., 1950, 74: 87-91. 19 refs. 

Exp. Biol., 

1445 

Swendseid, M. E., Wright, P. D. and Bethell, 

F. H. A GROWTH FACTOR FOR L. CITROVORUM 

SYNTHESIZED BY HEMOPOIETIC TISSUE REVER 

SING AMINOPTERIN AND CHLOROMYCETIN INHI 

BITION. Proc. Soc. 

1952, 80: 689-690. 

Exp. Biol., 

6 refs. 

N. T., 

1446 

Waisman, H. A., Green, M., MuÃ±oz, J. C., 

Ramenchik, 

AUREOMYCIN 

A. and Richmond, J. B. ROLE OF 

AND CITROVORUM FACTOR IN "FOUC 

ACID" DEFICIENCIES. Proc. 

N. T.. 1951, 76: 384-388. 

Soc. Exp. Biol., 

3 refs. 'Abstracted 

in: Biol. AbsÃ¯r., Bait., 1951, 25: No. 19766. 

See 

1381 1409 1474 


PROCESSES) 

1447 

Dinning, J. S., Day, P. L., Martindale, W. E., 

Olds, C. J., Pankey, M. J. and Wells, D. T. 

CREATINURIA DURING RECOVERY FROM AMINOPTERIN- 

INDUCED FOLIC ACID DEFICIENCY IN THE 

J. Biol. Chem., 1949, 181: 897-903. 

MONKEY. 

8 refs. 

Abstracted in: Chem. AlasTr., 1950, 44: No. 

2095e. "The data suggest that folie acid 

is involved in creatine formation." 

1448 

Dinning, J. S., Keith, C. K , Davis, P. L. and 

Day, P. L. THE INHIBITION OF CHICKEN-BONE- 

MARROW CHOLINE OXIDASE BY AMINOPTERIN IN VIVO. 

Arch. Biochem., 1950, 27: 89-93. 4 refs. 

The daily injection in aduli chickens of 1 mg. 

of aminopterin reduced peripheral leucocytes 

and total marrow cells to about 50% of con 

trol values in 4 days; after 13 days of 

treatment peripheral leucocytes were reduced 

to 53% of that of controls. Choline oxidase 

activity was exhibited in bone marrow from 

control birds but not in marrow from aminopterin-treated 

birds. Aminopterin may inhibit 

the choline oxidase of bone marrow by dis 

placement of folie acid from a position in 

the enzyme system. 

1449 

Dinning, J. S., Keith, C. K. and Day, P. L. 

A RELATIONSHIP OF FOLIC ACID TO CHOLINE OXI 

DASE. Arch. Biochem., N. Y., 1949, 24: 463- 

464. 

Sect. 

2 refs. 

2, 1951, 


4: No. 696. "Monkeys fed 

aminopterin, or deprived of folie acid 

death, exhibit a thirty-fold reduction 

until 

in 

the choline oxidase content of their livers 

and 

and 

kidneys. This was shown to be specific, 

not due to an overall reduction in enzymic 

activity by comparison with catalase. 

It could not be shown that folie acid had any 

effect on choline oxidase in vitro, but it 

may function as a constituent of the 

group of the enzyme." -Excerpta med. 

prosthetic 

1450 

Fenninger, L. D., Waterhouse, C. and Keutmann, 

E. H. THE INTERRELATIONSHIP OF NITROGEN AND 

PHOSPHORUS 

DISEASES. 

IN PATIENTS WITH CERTAIN NEOPLASTIC 

Cancer, Phila., 1953, 6: 930-941. 

1451 

Girdwood, R. H. THE METABOLIC EFFECTS OF 4- 

AMINOPTEROYLGLUTAMIC ACID IN THE 

Brit. J. Nutrit., 1951, Si 1-10. 

GUINEA PIG. 

15 refs. 

1452 

Goldthwait, D. A. EFFECT ON AMINOPTERIN ON IN 

CORPORATION OF CARSON14-FORMATE INTO THE 2 

AND 8 CARBONS OF GUANINE. Proc. Soc. Exp. 

Biol., N. Y., 1954, 86: 842-843. 

"The ratios of speciÃ¯Ã¯cactivity 

8 refs. 

of C-2 to 

C-8 of rat nucleic acid guanine, labeled 

in vivo with Cl4_formate, remained constant 

in aminopterin-treated 

trols." 

rats compared to con 

1453 

Goldthwait, D. A. and Bendich, A. EFFECTS OF 

A FOLIC 

BOLISM. 

ACID ANTAGONIST ON NUCLEIC ACID META 

J. Biol. Chem., 1952, 196: 841-852. 


47: 216d.



84 

GLÃœTAMICACID, 4-AMINOPTEROYL-, â€”¿METABOLISM 

(INCLUDING EFFECTS ON METABOLIC PROCESSES) 

(Continued) 

1454 

Grampa, G. AMINOPTERINA E TENORE NUCLEARE IN 

ACIDO DESOSSIRIBONUCLEINICO: MISURE FOTO- 

METRICHE SULL'INTESTINO DEL TOPO. [AMINO- 

PTERIN AND NUCLEAR CONTENT OF OESOXYRIBONU- 

CLEINIC ACID; PHOTOMETRIC MEASUREMENT IN 

MOUSE INTESTINE.] Boll. Soc. ital. biol. 

sper., 1953, 29: 1062-1004. 6 refs. 

Aminopterin iHEiblts the content of desoxyribonuclelc 

acid. 

Hanlon, D. G., Mason, H. L. and Stickney, J. M. 

THE URINARY EXCRETION OF 17-KETOSTEROIDS AND 

CORTICOSTEROIDS IN LEUKEMIA; THE EFFECT OF 

AMINOPTERIN(4-AMINOPTEROYLGLUTAMIC ACID) ON 

THE EXCRETION OF CORTICOSTEROIDS IN ACUTE 

LEUKEMIA. J. Laborat. Clin. M., 1950, 36: 

877-886. 8 reÃs. 

1455a 

Â»Introzzi, P. and Ventura, S. IL RICAMBIO DEL 

FERRO NELLE LEUCEMIE ACUTE E CRONICHE. [IRON 

METABOLISM IN ACUTE AND CHRONIC 

Haematologica, Pavia, 1954, 38: 

LEUKEMIAS.] 

475-512. 


No. 985. 

Llamas, R. INHIBICIÃ“N DE LA XANTINO-OXIDASA 

(DESHIDROGENABA XAÃŒTTICA)DEL, HÃ•GADO DE POLLO 

POR LOS AÃŽIDOS FOLICO Y FOLINICO Y POR EL 

NITRÃ’GENO DE MOSTAZA. [THE INHIBITION OF 

XANTHINE-OXIDASE (XANTI DEHYDROGENASE) OF 

THE CHICK LIVER WITH FOLIC AND FOLINIC ACIDS 

AND WITH NITROGEN MUSTARD.] An. Inst. biol., 

MÃ©x., 1953, 24: 3-14. 22 refs. 

14Martin, J. L. and Totter, J. R. EFFECT OF AMINO 

PTERIN ON RADIOACTIVITY OF RAT LIVER AND IN- 

TESTINAL-RIBONUCLEIC ACID AFTER Cl4 FORMATE 

INJECTION. Proc. Soc. Exp. Biol., N. Y., 1954, 

86: 41-42. 

1458 

Miller, Z. THE INFLUENCE OF AMINOPTERIN AD- 

MINlÃ¡TRATION ON CHOLINE AND FORMALDEHYDE 

OXIDATION BY MOUSE LIVER. Arch. Biochem., 

N. Y., 1954, 50: 337-346. 25 refs. Ab 


3: No. 3096; Leukemia Abstr., 1954, 2: 

No. 832. 

14N9ichol, C. A. and Welch, A. D. ON THE MECHANISM 

OF ACTION OF AMINOPTERIN. Proc. Soc. Exp. Biol. 

N Y 1950, 74: 403-411. 17 refs. Abstracted 

in: Excerpta 5Ã«d. Sect. 2, 1951, 4: No. 2127; 

Chem. Abstr., 1950, 44: 8524h. 

14Samarth, K. D., Baxi, A. J., Baliga, B. R. and 

Venkataraman, P. R. EFFECT OF AMINOPTERIN 

ON THE UPTAKE OF RADIOACTIVE PHOSPHORUS BY 

SOME ENDOCRINE TISSUES OF THE RAT. Current 

Sc., Bangalore, 1951, 20: 120-121. 15 refs. 

14tchoenbach, E. B., Colsky, J. and Lewis, R. A. 

STEROID EXCRETION IN PATIENTS RECEIVING ANTI- 

FOLIC ACID COMPOUNDS. Cancer, N. Y., 1950, 


Abstr., 1950, 44: 10904C. 

1462 Schwartz, M. A., De Salegui, M. and Â«IliÂ»Â«. 

J N , Jr. EFFECT OF DIETARY AMINOPTERIN 

AND SULFASUXIDINE ON BIOSYNTHESIS OF AS 

CORBIC ACID IN THE RAT. Proc. Soc. Exp. 

Biol., N. Y., 1954, 86: 858-862. 19 refs. 

^Skipper. H. E. NUCLEIC ACID METABOLISM AND 

EFFECTS OF CHEMOTHERAPY ON THIS AREA OF 

CH1JICAL EVENTS. Proc. CaÃ±ad. Cancer Conf., 

(1954) 1955, 1. Conf., 344-357. 27 refs. 

Contents: A search for exploitable differ 

ences in chemical events leading to syn 

thesis of nucleic acids in normal and neoplastic 

tissues. - Studies on the mechanism 

of action of temporary anticancer agents. - 

Investigation on the mechanisms involved in 

drug resistance in neoplastic cells. - 

Combination chemotherapy of experimental 

neoplasma and the guiding principles of 

sequential blocking. 

1464 Strength, D. R., Mondy, N. I. and Daniel, L. J. 

THE EFFECT OF AMINOPTERIN ON DIPHOSPHOPYRI- 

DINE NUCLEOTIDE. Arch. Biochem., N. Y , 1954, 

48: 141-148. 16 refs. 

1465 

Swendseid, M. E., Swanson, A. L., Miller, S. 

and Bethell, F. H. THE METABOLIC DISPLACEMENT 

OF FOLIC ACID BY AMINOPTERIN; STUDIES IN LEU 

KEMIA PATIENTS. Blood, Bait., 1952, 7: 302- 

306. 

1466 

Villela, G. G. and Mello, M. I. EFFECT OF 

PTEROYLGLUTAMIC ACID ON WEIGHT AND "ALKALINE" 

PHOSPHATASE 

Exp. Biol., 

OF KIDNEYS OF MOUSE. Proc. Soc. 

N. Y., 1949, 70: 453-454. 6 refs. 

Vitale, J. J., Zamcheck, N., DiGiorgio, J. and 

Hegsted, D. M. EFFECTS OF AMINOPTERIN AD 

MINISTRATION ON THE RESPIRATION AND MORPHOLOGY 

OF THE GASTROINTESTINAL MUCOSA OF RATS. 


12 refs. 

Waisman, H. A., Richmond, J. B. and Poncer, H. G. 

METABOLIC EFFECTS OF FOLIC ACID ANTAGONISTS 

IN ACUTE LEUKEMIA. A.M.A. Am. J. Dis. Child., 

1952, 84: 498-499. 

1469 

Â«Williams, J. N., Jr. EFFECT OF AMINOPTERIN ON 

CHOLINE, BETAINE ALDEHYDE, AND BETAINE ME 

TABOLISM. Proc. Soc. Exp. Biol., N. Y., 

1951, 78: 206-208. 

1470 Williams, J. N., Jr. THE EFFECTS OF FOLIC ACID 

AND AMINOPTERIN UPON ENZYME SYSTEMS IN VITRO. 

J. Biol. Chem., 1950, 187; 47-54. 10 refs. 


5: No. 448. "Data have been presented which 

Indicate that both folie acid and aminopterin, 

Â»hen added to enzyme systems in vitro, have 

very similar effects. The enzyme systems 

studied were endogenous respiration, xanthine 

oxidase, and choline oxidase of rat liver." 

1471 Williams, J. N., Jr., Chitre, R. G. and Elvehjem, 

C. A. EFFECTS OF FOLIC ACID AND AMINOPTERIN 

ON RAT LIVER METABOLISM. J. Biol. Chem.. 

1951, 190: 455-459. 11 refs. "Both folie 

acid ano~arainopterin added in vitro appears 

to influence rat liver endogenous respiration 

in a similar manner." 

See 

1346 MODE OF ACTION 

1472 

Dougherty, J. H. and Dougherty, T. F. ACUTE 

EFFECT OF 4-AMINOPTEROYLGLUTAMIC ACID ON 

BLOOD LYMPHOCYTES AND THE LYMPHATIC TISSUE 

OF INTACT AND ADRENALECTOMIZED Â«ICE. 


15 refs. 

1950, 44: 


5441b. "It is probable... that 

this compound has both an indirect hormonally 

mediated as well as direct inhibitory action 

on the lymphatic system. In contrast to 

this dual action of Aminopterin on the 

lymphatic system, the effect of this drug 

on myelopoiesis wus not mediated wholly or 

in part by pituitary 

secretion." 

and adrenal cortical



85 

GLUTAMIC ACID, 4-AMINOPTEROYL-, â€”¿MODE OF 

ACTION (Continued) 

1473 

Grampa, G. and Dustin, P., Jr. ANALYSE, PAR LA 

COLCHICINE, DES EFFETS RADIOMIMÃ‰TIQUES DE L1 

ACIDE 4-A11INO-PTÃ‰ROYLGLUTA1Ã•IQUE (AMINOPTÃ‰BINE) 

[ANALYSIS OF THE RADIOMIMETICEFFECTS OF 

AMINOPTERINBY THE USE OF COLCHICINE]. Rev 

beige path., 1952, 22: 113-125. 15 refs. Ab 

stracted in: ExcerpTÃ¤ med., Sect 16, 1954 

2: No. 1163. 

1474 Jacobson, W. A FOLIC ACID DERIVATIVE FUNCTION 

ING DURING CELL DIVISION. J. Physiol., 

1953, 122: 40-41P. 3 refs. 

Lond. 

1475 

Jacobson, W. THE MODE OF ACTION OF FOLIC ACID 

ANTAGONISTS 

1954, 123: 

ON CELLS. J. Physiol., Lond.. 

603-617. 1 pi. 25 refs. 

1476 

Ringsted, J. ON THE MECHANISM OF EXPERIMENTAL 

CARCINOGENESIS. VIII. THE GROWTH OF MILL- 

HILL ENDOTHELIOMA IN CHICKS TREATED WITH 

AMINOPTERIN. Acta path, microb. scand., 


ExcerpÃ¯Ã¯med., Sect. 16, 1954, 2: No. 1164; 

Chem. Abstr., 1953, 47: 11475g.~ "...tumour 

inhibiting effect of arainopterin is due to 

a prolonged excitation time and not a pro 

longed growth time." 

1477 

Â«Skipper, H. E., Riser, W. H., Jr. and Nolan, 

C. W. THE SPECIFICITY OF 4-AMINOPTEROYL- 

GLUTAMIC ACID (AMINOPTERIN) FOR LEUKEMIC 

HEMATOPOIETIC TISSUE. Blood. Bait., 1950 

5: 358-371. 

1478 Totter, J. R. ANTIMETABOLITE STUDIES ON BONE 

MARROW IN VITRO. In: Antimetabolites and 

cancer. (Rhoads, C. P., ed.) Washington 

Am. Acs. Advanc. Sc., 1955, 153-162. Biblio 

graphy: p. 161-162. 

See 

498 1419 1513 


See 

2886 THERAPY 

1479 

Aballi, A. J. and Barreras, L. COMPUESTO ANTI- 

FOLIÃ‡O (AMINOPTERINA) SU USO EN HEMOPATÃ•AS 

LEUCÃ‰MICAS. [ANTIFOLIC COMPOUNDS (AMINO 

PTERIN): THEIR USE IN LEUKEMIAS.] Rev. cubana 

laborat. clin., 1950, 4: 25-34. 7 refs. 

Findings in 21 cases are reported. 

1480 

Abbo, F. IL CUORE LEUCEMICO IN TRATTAMENTO 

AMINOPTERINICO. [THE LEUKEMIC HEART IN 

AMINOPTERIN 

Tor., 1954, 

TREATMENT.] 

6: 399-407. 

Minerva pediat., 

17 refs. 

1481 

A1???,5?eÂ£'C- P- ACUTE ALEUKAEMIC LYMPHATIC 

LEUKAEMIA TREATED WITH AMINOPTERIN AND BLOOD 

TRANSFUSIONS. 

43: 249-250. 

Proc. R. Soc. M., Lond , 1950 

A 5 year old girl was treated 

with aminopterin in doses of 1 mg. daily for 

15 days and with 12 blood transfusions. Petechiae, 

subcutaneous nodules and lymphadenopathy 

disappeared. The general condition of the 

patient was excellent at 14 weeks after treat 

ment . 

1482 

Allen, E. G. and Dick, H. J. A FATAL CASE OF 

ACUTE LEUCEMIATREATEDWITH AMINOPTERIN. 

Proc. N. York Ass. Pub. Health Laborat., 1948, 

28: 44-45. Discussion p. 45. 

1483 

Begemann, N. H. and Wijhe, M. van ERVARINGEN 

OVER DE BEHANDELING DER LEUCAEMIE MET AMINO- 

PTERINE. [EXPERIENCE IN AMINOPTERIN TREAT 

MENT OF LEUKEMIA.] Mschr. Kindergeneesk., 

1950, 1Ã•S:325-340. pi. 15 refs. English 

summary. Summary of this article in: Ned. 

tschr. geneesk., 1952, 96: 1495-1496. Re 

sults in aminopterin therapy of acute leuke 

mia in 10 children. 

1484 

Bergstrand, C. G. and Vahlquist, B. AMINOPTERIN 

OCH UTBYTESTRANSFUSION VID AKUT LEUKÃ„MI 

[AMINOPTERIN AND EXCHANGE TRANSFUSION IN ACUTE 

LEUKAEMIA.] Sven. lÃ¤k. tidn., 1948, 45: 2397- 

2403. 

Sect. 


7, 1949, Â£: No. 1407. 

in: ExcerpTa med., 

"A preliminary 

report is given *f two cases treated successively 

with aminopterine and exchange transfusion. The 

results indicated an effect by the aminopterine 

on the white blood 

megaly." -Excerpta 

picture 

med. 

and on the hepato 

1485 

Bergstrand, C. G., Rudert, P. O. and Vahlquist, B 

AMINOPTERIN UND AUSTAUSCHTRANSFUSION BEI AKUTER 

LEUKSMIE. [AMINOPTERIN AND EXCHANGE TRANS 

FUSION IN ACUTE LEUKEMIA]. Acta haemat., 1950, 

3: 178-201. Approx. 15 refs. English summary. 

Treatment in 10 cases. 

1486 

Berman, L., Axelrod, A. R., VonderHeide, E. C. 

and Sharp, E. A, TREATMENT OF CHRONIC LEUCE 

MIA WITH A FOLIC ACID ANTAGONIST. Proc. 

Centr. Soc. Clin. Res., 1948, 21: 90-92. 

1487 

Berman, L., Axelrod, A. H., Vonder Heide, E. C. 

and Sharp, E. A. USE OF A FOLIC ACID ANTA 

GONIST IN CHRONIC LEUKEMIA. Am. J. Clin. 

Path., 1949, 19: 127-133. 15 refs. Nine 

patients with~chronic leukemia were given 

4-amino pteroylglutamic acid orally in daily 

doses ranging from 1.25 to 7.5 mg for 6 to 

25 days. Stem cells, granulocytes and im 

mature lymphocytes decreased but mature 

lymphocytes were not affected. Megaloblasts 

appeared in the marrow. While the compound 

produced a definite hÃ©matologie effect, 

there was no subjective improvement in the 

patients. 

1488 

Bernard, J. and MathÃ©, G. Ã‰TUDEDES LEUCOSES 

AIGUÃ‹SDE L'ENFANCE TRAITÃ‰ESPAR L'ASSOCIATION 

ANTIFOLIQUES CORTISONE. [REPORT ON COMBINED 

ANTIFOLIC CORTISONETREATMENTOF ACUTELEU 

KEMIA.] Sang, Par., 1952, 23: 12-27. 53 refs. 

Abstracted in: Index analyt. cancer. Par 

1952, 2Â£: No. 548. 

1489 

Bernard, J. and MathÃ©, G. LE TRAITEMENT PRATIQUE 

DES LEUCOSES AIGUÃ‹S. [TREATMENT OF LEUKEMIAS.l 

Rev. pract..,par., 1954, 4: 1379-1382. 2 refs. 

Abstracted in: Leukemia Ã‚bstr., 1954, 2: No.971. 

1489a 

Eichel, J. CHEMOTHERAPY OF CANCER. Acta radiol 

Stockh., 1951, 36: 437-451. 53 reÃs. "A 

survey of the acTion of the antineoplastic chemi 

cals directly affecting cancer cells is given. 

An illustrative case successfully treated by 

aminopterin is described." 

1490 

Boll, I. ÃœBER DIE BEHANDLUNG DER AKUTEN LEU- 

KAEMIEN MJT FOLSAUREANTAGONISTEN UND ACTH 

UNTER BERÃœCKSICHTIGUNG EINES EIGENEN FALLES. 

[TREATMENT OF ACUTE LEUKEMIA WITH FOLIC ACID 

ANTAGONISTS AND ACTH, CONSIDERED WITH A PER 

SONAL CASE.] Aerztl. Wschr., 1953, 8: 516- 

519. 51 refs. Abstracted in: Leukemia 

Abstr., 1953, _!: No. 318.



86 


(Continued) 


1491 

Bruton, O. C. and Price, W. S. TREATMENT OF 

LEUKEMIA IN CHILDREN. 

J., 1952, 3: 461-468. 

U.S. Armed Forces H. 

13 rets. Observations 

on 15 patients. 

1492 

Buisine. A. and Henninot, Â£. LEUCOSE AIGUÃ‹ 

CHEZ UN ENFANT DE HUIT ANS; TRAITEMENT PAR 

EXSANGUINO-TRANSFUSJONS, TRANSFUSIONS ET 

AMINOPTERINE. SURVIE EXCEPTIONNELLE DE 

20 MOIS. [ACUTE LEUKEMIA IN AN EIGHT YEAR 

OLD CHILD; TREATMENT WITH EXSANGUINO- 

TRANSFUSIONS, TRANSFUSIONS AND AMINDPTERIN. 

EXCEPTIONAL SURVIVAL TIME OF 

J. se. mÃ©d. Lille, 1950, 68: 

20 MONTHS.] 

467-470. 

1493 

Burchenal, J. H. PRESENT STATUS OF ACTH, COR 

TISONE, AND THE ANT[METABOLITES IN THE TREAT 

MENT OF LEUKEMIA AND RELATED DISEASES. Acta 

baemat., Basel, 1952, 7: 193-205. 60 refs. 

Also in: C. rend. Internat. Europ. Soc. Hemat. 

Rome (1951) 1952, 3. Congr., 397-407. 

1494 

Burchenal, J. H. TREATMENT OF ACUTE LEUKEMIA 

IN CHILDREN. Pediatrics, 1951, 8: 730-731. 

Round table discussion. 

1495 

Cameron, D. G., Townsend, S, R., Hills, E. S. 

and Mathews, W. H. ACTH AND CORTISONE Ã•NTHE 

TREATMENT OF ACUTE LEUKAEMIA. CaÃ±ad. M. Ass. 

J., 1951, 65: 552-555. 

1496 

C[loughl, "F ACUTE P. LEUKEMIA. W. AMINOPTERIN Ann. Int. IN THE Med., TREATMENT 1949, 

OF 

31: 1129-1132. 11 refs. An editorial. 

1497 

Colebatch, J. H. and Williams, A. L. SHOULD 

WE TREAT LEUCHAEMIA IN CHILDHOOD? Med. 

Australia, 1950, 2: 892-895. 3 refs. 

J. 

Treatment of 18 cases of leukemia. 

1498 

Colsky, J., Greenspan, E. M. and Warren, T. N. 

HEPATIC FIBROSIS IN CHILDREN WITH ACUTE LEU 

KEMIA AFTER 

A.M.A. Arch. 

THERAPY WITH FOLIC ACID ANTAGONISTS. 

Path., 1955, 59: 198-206. 19 refs. 

1499 

Conley, C. L. AMINOPTERIN IN THE TREATMENT OF 

ACUTE LEUKEMIA. Bull. Johns Hopkins Hosp., 

1949, 84: 395. 

1500 

CORNELL CONFERENCES ON THERAPY. TREATMENT OF 

LEUKEMIA. 

2910-2918. 

N. York State J. M., 1952, 52: 

1501 

Cottle, R. I. and Battle, J. D. Jr. TREATMENT 

OF ACUTE LYMPHATIC LEUKEMIA WITH AMINOPTERIN. 

Cleveland Clin. Q., 1952, 19: 67-71. 6 refs. 

Of 12 patients, 6 derived temporary benefit, 

the improvement lasting from a few days to 

3 months; 1 patient obtained a partial re 

mission, which lasted for 14 months; 5 patients 

received no benefit. 

1502 

Dacie, J. V., Dresner, E., Mollin, D. L. and 

White, J. C. AMINOPTERIN 

ACUTE LEUKEMIA. Brit. M. 

IN THE TREATMENT OF 

J., 1950, 1: 1447- 

1457. 24 refs. Abstracted in: BiolT Abstr., 

Bait., 1951, 25: No. 5086. 

1503 

Danis, P. G. MANAGEMENT OF ACUTE LEUKEMIA. 

J. Missouri M. Ass., 1952, 49: 821-825. 

1504 Dameshek, W., Freedman, M. H. and Steinberg, L. 

FOLIC ACID ANTAGONISTS IN THE TREATMENT OF 

ACUTE AND SUBACUTE LEUKEMIA. Blood, Bait., 

1949, 4: 898-915. 13 refs. Treatment in 

40 cases is reported. 

1505 Dresner, E. THE BONE AND JOINT LESIONS IN 

ACUTE LEUKAEMIA AND THEIR RESPONSE TO FOLIC 

ACID ANTAGONISTS. Q. J. Med., Oxf., 1950, 

1JJ: 339-352. 6 pi. 33 refs. 

1506 

Elwood, J. S. and Balint, J. A. ACUTE LEUKEMIA 

TREATED WITH AMINOPTERIN; 3 CASES. S. Thomas 

Hosp. Rep., l.imil., 1950, 6: 265-272. 

1507 

Farber, S., Diamond, L. K., Mercer, R. D., 

Sylvester, R. F.. Jr. and Wolff, J. A. TEM 

PORARY REMISSIONS IN ACUTE 

REN PRODUCED BY FOLIC ACID 

LEUKEMIA IN CHILD 

ANTAGONIST, 4- 

AMINOPTEROYLGLUTAMIC ACID (AMINOPTERIN). 

N. England J. M., 1948, 238; 787-793. 5 refs. 

Abstracted in: Chem. Abstr.. 1948, 42: 6907b; 


"Clinical hematological and histologie de 

tails of 5 patients with acute .leukemia 

treated with aminopterin..." 

1508 Fraser, R. and White, J. C. MONOCYTIC LEUKE 

MIA IN AN 

Postgrad. 

ADULT TREATED 

M. J., Lond., 

WITH AMINOPTEHIN. 

1950, 26: 85-90. 

1509 

Gasser, C. and Cramer, R. LEUKÃ„MIE IM KINDESALTER 

UNTER CORTISON UND AMINOPTERIN. [TREATMENT OF 

CHILDHOOD LEUKEMIA WITH CORTISONE AND AMINO 

PTERIN.] Helvet. paediat. acta, 1953, 8: 10- 

89. 35 refs. Abstracted in: Leukemia Abstr., 

1953, 1: No. 418. "Aminopterin was used 

only alter preliminary treatment with cortisone, 

producing 1 complete and several partial re 

missions in blast-cell leukemias, and a lasting 

complete remission in a case of promyelocytic 

leukemia. The authors 

effect of cortisone by 

explain the beneficial 

its specific antianabolic 

action on leukemia cells, as opposed to 

the generalized inhibitive 

pterin on all the cells of 

influence of 

the marrow." 

amino 

-Leukemia Abstr. 

1510 

Gendel, B. R., Kraus, A. P. and Green, f. D. 

AMINOPTERIN IN THE TREATMENT OF ACUTE LEUKE 

MIA OF ADULTS. 

97-102. Out of 

Am. Practitijner, 

25 adults treated 

1952, 

with 

3: 

Aminopterin only two remissions were obtained: 

a complete remission lasting 6 months in 1 

patient and a partial remission lasting 4 

months in another patient. Toxic reactions 

to the drug were frequent. 

1511 

Gerwelowa, H. and Szczepski, O. PRZYPADEK 

BIAtACZKI U DZIEKA LECZONY AMINOPTERYNA 

ORAZ PRZYPADEK ODCZYNU BIAlACZKOWEGO W 

PRZEBIEGU ZAKAZENIA. [A CASE OF LEUKEMIA 

IN A CHILD TREATED WITH AMINOPTERIN, AND 

A CASE OF LEUKEMIC REACTION IN THE COURSE 

OF INFECTION.] Pediat. polska, 1952, 27: 

73-81. 6 refs. English summary. Neither 

of the two children treated with aminopterin 

and other drugs survived. In one 

a six months' remission occurred. 

child 

1512 Goidsenhoven, F. van and Broekaert, R. ACUTE 

LEUKAEMIE BEHANDELD MET CORTISONE EN AMINO 

PTERINE. [ACUTE LEUKEMIA TREATED BY CORTI 

SONE AND AMINOPTERIN]. Belg. tschr. geneesk., 

1951, 7: 789-792. A 2 months complete clini 

cal remission is reported in an 8 year old 

child with combined treatment of cortisone 

given in two courses of 1.200 mg and of amino 

pterin in 350 mg and of 7.5 mg administered 

over a 2 weeks period. 

1513 

Gouttas, A., Tsevrenis, H., Rombos, K. and 

Fessas, F. CONTRIBUTION A L'Ã‰TUDE DE L'ACTION 

DE L'AMINOPTÃ‹RINE SUR LES LEUCÃ‰MIES AIGUÃ‹S. 

[CONTRIBUTION TO THE STUDY OF THE ACTION OF 

AMINOPTERIN ON ACUTE LEUKEMIAS.] Sang, Par., 


Leukemia Abstr., 1953, 1: No. 16.



87 


(CONTINUED) 


Grinberg, R. EL USO DE LOS ANTIFOLICOS EN EL 

TRATAMIENTO DE LOS TUMORES MALIGNOS DE LA 

MAMA EN LA MUJER. [USE OF FOLIC ACID ANTAGO 

NISTS IN THE TREATMENT OF MALIGNANT BREAST 

TUMORS IN WOMEN]. Dia ned., B. Air., 1951, 

23: 61-62. 12 reÃs. 

Harris. L. J. LEUKEMIA AND PREGNANCY. CaÃ±ad. 

M. Ass. J., 1953, 68: 234-236. 25 reÃs. 

Abstracted in: LeuEÃ«iniaAbstr., 1953, 1^ 

No. 180. 

1516 Hart, P. L. de V. A CASE OF MONOCYTIC LEUKE 

MIA TREATED WITH AMINOPTERIN. Brit. M. J., 

1949, 2: 363-364. 4 refs. 

1517 

Haverkamp Begemann, N. and Wijhe, M. van. 

ERVARINGEN OVER DE BEHANDELING DER LEUCAEMIE 

MET AMINOPTERINE. [EXPERIENCES WITH AMINOPTERIN 

IN THE TREATMENT OF LEUKEMIA]. Mschr. kindergeneesk., 

1950, 18: 325-340. 15 refs. 

1518 

Hendricks, A. B. and Fowler, Â».II. FOLIC ACID 

ANTAGONISTS IN THE TREATMENT OF LEUKEMIA. 

J. Iowa M. Soc., 1951, 41: 84-86. 8 refs. 

Ten oases. 

1519 

Hunter, O. B., Jr. and Carroll, G. J. AMINO 

PTERIN (4-AMINO-PTEROYL-GLUTAMIC ACID) THERA 

PY 

3: 

IN LEUKEMIAS. Ann. Western M. & S., 1949, 

380-384. 3 refs. Abstracted in: Biol, 

Sbstr., Bait., 1950, 24: No. 6342. 

15Imerslund, O. AKUTT LEVKEMI HOS BARN-BEHANDLET 

MED AMINOPTERIN. [ACUTE LEUKEMIA IN A CHILD, 

TREATED WITH AMINOPTERIN.] Tskr. Norske 

laegeforen., 1951, 71; 322-323. 4 refs. 

"Complete remission-clinical as well as hematologic-occurred 

in both cases following 

treatment with 10-12 mg of aminopterin for 

three to four weeks." 

1521 Jersild, T. and Mehlsen. S. AMINOPTERIN-BEHAND- 

LING Ã‚F LEUKAEMI I BARNEALDEREN. [AMINOPTERIN 

THERAPY OF LEUKEMIA IN CHILDHOOD.] Ugeskr. 

laeger, 1950, 112: 1354-1359. 14 refs. 

English summary. Two cases of stem-cell leu 

kemia treated with aminopterin. 

1522 Jersild, T. and Mehlsen. S. AMINOPTERIN THERA 

PY IN LEUKEMIA IN CHILDHOOD. Acta paediat., 

Upps., 1951, 40: 127-142. 13 refs. 

1523 JimÃ©nez de Asua, F. AMINOPTERINA EN LAS LEUCEMIAS 

AGUDA. [AMINOPTERIN IN ACUTE LEUKEMIAS]. Rev. 

Soc. argent. Hemat., 1949, 1: 353-369. 38 refs. 


1533 Karpinski, F. E., Jr. and Martin, J. F. THE 

SKELETAL LESIONS OF LEUCEMIC CHILDREN TREATED 

WITH AMINOPTERIN. J. Pediat., S. Louis, 1950 


mÃª~d.,Sect. 7, 1951, 5: No. 1026. 

15Karpinski, W. BEITRAG ZUR BEHANDLUNG DER AKUTEN 

LEUKÃ„MIE IM KINDESALTER. [CONTRIBUTION TO THE 

TREATMENT OF ACUTE LEUKEMIA IN CHILDHOOD.] 

Wien. med. Wschr., 1953, 103: 269-270. 21 refs. 

Report of a case of paraleukoblastic leukemia 

in an infant treated with cortisone for 5 weeks 

and maintained for approximately 2 months on 

1 mg of aminopterin twice a week. 

15iclech, M. K. and Scott, F. E. T. ALEUKAEMIC 

MYELOID RETICULOSIS: REPORT OF A CASE TREATED 

WITH AMINOPTERIN. J. Path. Bact., Lond., 


Leukemia: Abstr., 1953, 1: No. 185. "Treat 

ment with aminopterin dTd not arrest the 

progress of the disease or prevent its fatal 

termination." 

15Kelty, K. C. and Beard, M. F. THERAPY OF ACUTE 

LEUKEMIA. Am. Practitioner, 1953, 4: 375- 

381. 6 refs. Abstracted in: Leukemia Abstr., 

1953, 1: No. 299. "It is concluded that the 

best treatment results were obtained in those 

patients receiving antifolics and ACTH or 

cortisone alternately; each one showed sub 

stantial improvement, becoming asymptomatic 

for 1-3 months, but only one complete remis 

sion was noted, obtained while the patient 

was receiving ACTH after aminopterin therapy." 


1537 

KhO, L. K. EXPERIENCES WITH MODERN TREATMENT 

OF LEUKAEMIA 

Basel, 1954, 

IN CHILDHOOD. 

182: 202-217. 

Ann. paediat., 


Koch, K. STUDY OF AMINOPTERIN TREATMENT IN 

CHILDHOOD LEUKEMIA; A COMPARISON OF THE PATHO 

LOGICAL FINDINGS 

WITH AMINOPTERIN 

IN CASES OF LEUKEMIA 

AND UNTREATED CASES. 

TREATED 

96t. 

Minneapolis, 1955. (Thesis-Univ. of Minn.) 

Typewritten copy. 

*ÃŽ 

KÃlbl, H. and Rosenkranz, A. EIN BEITRAG ZUR 

AMINOPTERINTHERAPIE AKUTER LEUKÃ„MIEN. [AMINO 

PTERIN THERAPY OF ACUTE LEUKEMIAS.] Wien. 

klin. Wschr., 1952, 64: 309-311. 16 refs. 

1540 Kracke, R. R. and Rise, W. H., Jr. AMINOPTERIN 

THERAPY IN ACUTE LEUKEMIA. Am. J. Med., 1949, 

7: 260. 

1541 

Laski, B., Darte, J. M. M., Snelling, C. E. 

and Donohue. W. L. FOLIC ACID ANTAGONISTS 

IN THE TREATMENT OF LEUKEMIA IN CHILDREN. 

CaÃ±ad. M. Ass. J., 1951, 65: 556-560. 3 refs. 

Thirteen of 53 patients had a complete or 

partial clinical and hematological remission 

of short duration with some prolongation of 

life. 

i 542 

Levin, W. C., Jacobson, Â». and Holt, G. OB 

SERVATIONS ON THE TREATMENT OF ACUTE LEUCE 

MIAS WITH ANALOGUES OF FOLIC ACID. Proc. 

Centr. Soc. Clin. Res., 1948, 2_1: 88-89. 

1543 Lien-Keng, K. EXPERIENCES WITH MODERN TREAT 

MENT OF LEUKAEMIA IN CHILDHOOD. Ann. Paediat. 

Basel., 1954, 182: 202-217. About 50 refs. 

1544 Lien-Keng, K. A HYPERACUTE CASE OF ERYTHRO- 

LEUKAEMIA TREATED WITH AMINOPTERIN. Acta 

paediat., Upps., 1953, 42: 157-165. 28 refs. 

Aminopterin adjninisterecTin 0.5 mg, twice 

daily for 5 days to a boy of 7 months with 

erythroleukemia did not influence the acute 

fatal outcome. However, myeloblasts, promyelocytes 

and myelocytes soon disappeared 

from the blood. The liver and spleen grew 

smaller. Autopsy revealed erythroid and 

myeloid proliferations in the marrow, liver, 

spleen, lymphoids, thymus and intestines. 

1545 McCall, F. C. and Scherer, J. H. THE TREATMENT 

OF ACUTE LEUKEMIA WITH THE FOLIC ACID ANTAGO 

NIST, AMINOPTERIN. Virginia M. Month., 1950, 

77: 273-279. Discussion: p. 278-279. 6 refs. 

1546 

Magnin, G. E., Rotter, R. and Meyer, O. 0. THE 

TREATMENT OF ACUTE LEUKEMIA WITH COMBINED 

STEROID HORMONES AND FOLIC 

Wisconsin M. J. , 1953, 52: 


120-127. 4 refs.



88 


(Continued) 


1547 Hallarme, J. L'AMINOPTÃ‰RINE COMMETRAITEMENT 

DE LA LEUCOSE MALIGNE ET SON ANTIDOTE: L'ACIDE 

FOLINIQUE. [AMINOPTERIN AS A TREATMENT FOR 

MALIGNANT LEUCOSIS, AND ITS ANTIDOTE: FOLINIC 

ACID.] Sang, Par., 1952, 23: 605-606. 

Abstracted in: Leukemia AbsTr., 1953, 1^: No. 

24. 

1548 

Maness, P., Hansen-Pruss, O. C., McPherson, A. Z. 

and Stoddard, L. D. TREATMENT OF ACUTE LEU 

KEMIA WITH AMINOPTERIN. Am. J. Med., 1949. 

7: 129. 

1549 

Marie, J., Bernard, J., Salet, J. and Cruciani. 

ESSAIS DE TRAITEMENTDES LEUCOSESAIGUÃ‹SDE 

L'ENFANT PAR L'ASSOCIATION AMINOPTERINE-COR- 

TISONE. [ATTEMPTTO TREATACUTE LEUKEMIAIN 

CHILDRENBY A COMBINEDTHERAPYOF AMINOPTERIN 

AND CORTISONE]. Bull. Soc. med. hop. Paris, 


Index analyt. cancer, Par., 1952, 23: No. 894. 

1550 

Marmont, A. PRIMI RISULTATI CON IL TRATTAMENTO 

CON AMINOPTERINA DELLE LEUCEMIE ACUTE (COM- 

MUNICAZIONE PRELIMINARE). [FIRST RESULTS OF 

THE AMINOPTERIN TREATMENT IN ACUTE LEUKEMIA. 

(PRELIMINARY COMMUNICATION).] Minerva pediat., 

Tor., 1950, 2: 288-296. Approx. 40 refs. 

Abstracted in: Excerpta med,, Sect. 7, 1951, 

5J No. 1361. 

1551 

Â»Marmont, A. and Fusco, F. GLI ANTAGONISTI 

DELL'ACIDO FOLICO NEL TRATTAMENTO DELLE 

LEUCOSI ACUTE. [FOLIC ACID ANTAGONISTS 

IN THE 

Accad. 

TREATMENT OF ACUTE LEUCOSES.] 

med., Tor., 1953, 68: 114-122. 


1954, 3:'No. 2735. 

mecT., Sect. 16, 

1552 

Maurea, C. and Arciello, G. L'AMINOPTERINA IN 

DUE CASI DI LEUCEMIA ACUTA. [AMINOPTERIN IN 

TWO CASES OF ACUTE LEUKEMIA.] Minerva med., 

Tor., 1951, 42: pt. 2, 871-877. 

Detailed casÃ«~~histories. 

43 reÃs. 

1553 Meyer, L. M. and Neiraan, A. TREATMENT OF LEU 

KAEMIA WITH AMINOPTERIN. Am. J. Med., 1951, 

10: 452-458. 20 refs. Abstracted 

cerpta Â«ed., Sect. 2, 1952, 5: No. 

in: Ex 

1683. 

1554 

Meyer, L. M., Fink, II., Savitsky, A., Rowen, M. 

and Ritz, N. D. AMINOPTERIN (A FOLIC ACID 

ANTAGONIST) IN THE TREATMENT OF LEUKEMIA. 

Am. J. Clin. Path., 1949, 19: 119-126. 

1555 Mills, S. D., Stickney, J. M. and Hagedorn, A. B. 

OBSERVATIONS ON ACUTE LEUKAEMIA IN CHILDREN 

TREATED WITH 4-AMINOPTEROYLGLUTAMIC ACID. 

Pediatrics, 1950, 5: 52-56. 8 refs. Abstrac 

ted in: Excerpta med., Sect. 7, 1950, 4: No. 

3006; Chem. Abstr., 1952, 46: 8253Ã•. ' 

1556 

Mickle, K. C., Muscato, G. V., Lemanski, A. and 

Claudon, D. B. TREATMENTOF LEUCEMIAIN 

CHILDHOOD. J. Pediat., S. Louis, 1951, 39: 

442-447. 6 retÂ». 

1557 

Â»Miller, F. R. AMINOPTERIN IN TREATMENT OF LEU 

KEMIA. Philadelphia M., 1947-1948, 43: 1609. 

1558 

Â»Moody, E. A. and Davis, R. W. DURATION OF ACUTE 

LEUKEMIA IN CHILDREN. REVIEW OF THE LITERATURE 

AND REPORT OF A CASE OF UNUSUALLY LONG 

An. J. Dis. Child., 1950, 80: 955-962. 

SURVIVAL. 

Abstrac 

ted in: Excerpta med., Sect, 7, 1951, 5: No. 

1575. 

1559 

Pierce, M. TREATMENT OF LEUKEMIA IN CHILDREN. 

Am. J. Dis. Child. 1949, 78: 137-139. 

cussion: p. 137-139. An attract. 

Dis 

1560 

Pierce, M. and Alt, H. TREATMENT OF ACUTE LEU 

CEMIA WITH AMINOPTERIN (4-AMINO-PTEROYLGLU- 

TAMIC ACID). J. Laborat. Clin., M., 1948, 

33: 1642-1643. Also in: Proc. Centr. Soc. 

CTin. Res., 1948, 2^: 89-90. An abstract. 

1561 

Quilligan, J. J. CHILDHOOD MALIGNANCIES. V. 

CHEMOTHERAPY OF LEUKEMIA. Tex. J. M., 1952, 

48_: 571-575. 12 refs. 

1562 

Rambach, W. A. and Alt, H. L. TREATMENT OF 

LEUKEMIA. GP, 1952, 5: 67-73. A review. 

1563 

Rice, E. C., Cassidy, J. E., Leyva, F. R., Crowell, 

W. M., Judge, D. J., Troendle, F. J. and Vaden, 

E. B. TREATMENT OF LEUKEMIA IN CHILDREN WITH 

FOLIC ACID ANTAGONISTS. 

Wash., 1950, 6: 267-276. 

Clin. PrÂ«c. Child. 

15 refs. 

Hosp., 

1564 

Rinvik, R. AKUTT LEVKEMI BEHANDLET MED AMINO 

PTERIN. [ACUTE LEUKEMIA TREATED WITH AMINO 

PTERIN. ] Tskr. Norske 

319-321, 323. 9 refs. 

laegeforen., 1951, 


71: 

Oral administration 

of acute stem-cell 

of aminopterin in 2 cases 

leukemia resulted in com 

plete remission. 

1565 

Ross, R. T. and Schoemperlen, C. B. THE EFFECT 

OF AMINOPTERIN AND PARTIAL EXSANGUINATION 

TRANSFUSION ON A CASE OF ACUTE STEM CELL LEU 

KEMIA; A CASE REPORT AND REVIEW OF THE LITERA 

TURE ON THESE TWO PROCEDURES. Ann. Int. M., 

1950, 32: 123-128. 7 refs. 

1566 

Â»Ruggeri, F. GLI ANTIFOLICI NELLA CURA DELLE 

LEUCEMIE. 

TREATMENT OF[FOLIC LEUKEMIAS.] ACID ANTAGONISTS ArcispÃ«d. INS.'Anna 

THE 

di Ferrara Riv., 1952, 5: 473-479. Abstracted 

in: Leukemia Abstr., 1954, 2: No. 489. 

1567 

Sacks, M. S., Bradford, G. T. and Schoenbach, 

E.B. THE RESPONSE OF ACUTE LEUKEMIA TO THE 

ADMINISTRATION OF THE FOLIC ACID ANTAGONISTS, 

AMINOPTERIN AND A-METHOPTERIN: REPORT OF 14 

CASES. Ann. Int. M., 1950, 32: 80-115. 

38 refs. 

1568 

Â»Sansone, G. and Leva, R. TRATTAMENTO DELLE LEU 

CEMIE ACUTE DELL'INFANZIA CON AMINOPTERINA. 

[TREATMENT OF ACUTE LEUKEMIA IN CHILDHOOD WITH 

AMINOPTERIN.] Accad. med., Genova, 1953, 68: 

113-114. 

1569 

Sansone, G., Leva, R. and Piga, A. LA TERAPIA 

MODERNA DELLA LEUCEMIE ACUTE DELL'INFANZIA. 

RISULTATI DI 24 CASI. [MODERN THERAPY OF 

ACUTE LEUKEMIA IN INFANTS. RESULTS IN 24 

CASES.] Minerva pediatr., Tor., 1954, 6: 

471-473. tab. 

1570 Schoenbach, E. B., Colsky, J. and Greenspan, 

E. M. OBSERVATIONS ON THE EFFECTS OF THE 

FOLIC ACID ANTAGONISTS, AMINOPTERIN AND 

AMETHOPTERIN, IN PATIENTS WITH ADVANCED 

NEOPLASMS. Cancer, Phila., 1952, 5: 1201- 

1220. 2 pi. 58 refs. 

1571 

Silverman, F. N. ROENTGENOGRAPHIC CHANGES IN 

LONG BONES OF LEUKEMIC CHILDREN TREATED WITH 

"AMINOPTERIN." Am. J. Dis. Child., 1950, 

79: 1126-1127.



89 

GLUTAMIC ACID, 4-AMINOPTEROYL-, â€”¿ THERAPY 

(Continued) 

1572 

Smith, C. H. and Bell, W. R. AHINOPTERIN IN 

TREATMENT OF LEUCAEMIA IN CHILDREN; SERIAL 

ASPIRATIONS OF BONE MARRO* AS A GUIDE TO 

MANAGEMENT AND APPRAISAL OF TREATMENT. Am. 

J. Dis. Child., 1950, 79: 1031-1048. 21 refs. 

1573 

Solari, J. EVALUACIÃ“N DEL TRATAMIENTO DE LAS 

LEUCEMIAS CON ANTAGONISTAS DEL ACIDO FÃ“LICO. 

[EVALUATION OF THE TREATMENT OF LEUKEMIA 

WITH FOLIC ACID ANTAGONISTS.] Rev. 

pediat., 1950, 20: 82-90. 8 refs. 

peruana 

Abstracted 

in: Excerpta meST, Sect. 7, 1951, 5: No. 1028. 

1574 

Soto A[llande], R. ANTIFOLICOS Y LEUCEMIAS 

AGUDAS INFANTILES. [FOLIC ACID ANTAGONISTS 

AND ACUTE LEUKEMIAS IN CHILDREN.] Boi. ned. 

Hosp. inf., Mex., 1952, 9: 19-28. English 

summary, Findings in 16 cases of acute 

leukemias and one case of Hodgkints disease 

treated with folie acid antagonists. 

1575 

Soto A[llande], R. LEUCEMIAS AGUDAS T AMINO 

PTERIN. [ACUTE LEUKEMIA AND AMINOPTERIN.] 

Boi. med. Hosp. inf., Mex., 1950, 7: 43-55. 

6 refs. English .summary. Seven ca~se his 

tories. 

1576 

Sturgis, C. C. THERAPEUTIC AGENTS IN HEMATOLOGY. 

Postgrad, la., 1953, 14: 198-205. Substantially 

the same report appears in: J. M. Ass. Georgia, 

ÃÂ»53,42: 445-450. Abstracted in: Leukemia 

Abstr.TT.953, Â¿: No. 372. A short review. 

1577 Tachoyan, S. DEUX CAS DE LEUCOSE AIGUÃ‹ TRAITÃ‰S 

PAR L'AMINOPTERINE. [TWO CASES OF ACUTE LEU 

KEMIA TREATED WITH AMINOPTERIN.] Rev. im',1. 

Moyen Orient, 1951. 8: 356-365. Discussion: 

p. 364-365. 

1578 

Taylor, S. G., Hass, G. M., Crumrine, J. L. 

and Slaughter, D. P. 

4-AMINOPTEROYLGLUTAMIC 

TOXIC REACTIONS OF 

ACID(AMINOPTERIN) 

IN PATIENTS WITH FAR-ADVANCED NEOPLASTIC 

DISEASE. Cancer, N. Y., 1950, 3J 493- 


med., Sect. 5, 1951, 4: No. 1331; Chem. 

Abstr., 1950, 44: 651Zc. 

1579 TUMOR CLINIC CONFERENCE, CASE NO. B-7865. 

Cancer Bull., Texas. 1953. 5: 94-96. Ab 

stracted 

No. 435. 

in: Leukemia AbstrT, 1953, 1: 

"The case history of a patient 

with subacute monocytic 

leukemia is presented." 

and myelogenous 


1580 Verrotti, M. ALCUNI RILIEVI SULLA CURA DELLA 

LEUCEMIA ACUTA CON PARTICOLARE RIFERIMENTO 

ALLA TERAPIA CON AMINOPTERINA; CONTRIBUTO 

CLÃ•NICO. [THERAPY OF ACUTE LEUKEMIA WITH 

SPECIAL REFERENCE TO AMINOPTEHIN; CLINICAL 

REPORT.] 

138-166. 

Stud. Fac. 

58 refs. 

med. senese, 1953, 12: 

1581 

Weber, E. J., Karpinski, F. Â£., Jr. and Heinle, 

R. W. TREATMENT OF ACUTE LEUKEMIAS OF CHILD 

HOOD WITH 

S. Louis, 

FOLIC 

1950, 

ACID ANTAGONISTS. J. Pediat., 

36: 69-78. 10 refs. Abstrac 

ted in: Excerpta med.. Sect. 7, 1950, 4: No. 

3007. 

1582 Wilkinson, J. F. and Gardikas, C. TREATMENT OF 

ACUTE LEUKAEMIA WITH AMINOPTERIN. 

I,uncÃ.,1951, 1: 325-327. 13 refs. 

Lancet, 

Twentyseven 

patients with acute myeloid, lymphatic, 

or monocytic leukemia were given aminopterin 

intramuscularly in doses of 1 mg daily, or on 

alternate days. Treatment had to be discon 

tinued in 6 cases. Of the remaining 21 patients, 

the drug produced no response in 15, partial 

remissions in 4, and complete, but brief re 

missions in 2(aged 15 and 2 1/2) 

1583 

Wilson, S. J. OBSERVATIONS ON THE EFFECT OF 

VARIOUS FOLIC ACID ANTAGONISTS ON ACUTE 

LEUKEMIA. Blood, Bait., 1951, 6: 1002- 1012. 

23 refs. Study of 65 patients. 

1584 

Wolman, I. J., Eglick, P., Dickstein, B. and 

Githens, J. LEUKEMIA IN CHILDHOOD; PRELIMI 

NARY REPORT OF RESPONSE TO AMINOPTERIN. 

Pennsylvania M. J.. 1949. 52: 474-481. 

See 

375 

1035 

1271 

1585 

2016 

2388 

TOXICITY 

520 

1042 

1286 

1603 

2036 

2394 

548 

1046 

1377 

1676 

2259 

2451 

608 

1135 

1390 

1680 

2299 

2497 

686 

1228 

1423 

1681 

2308 

1585 

Abbasy, A. 

Pediat., 

S. AMINOPTERIN IN LEUKEMIA. 

1950, 67: 133-134. 4 refs. 

Arch. 

Amino 

pterin even in small and infrequent doses 

gave a dramatic and rapid hÃ©matologie re 

mission and severe toxic reactions in a patient 

with acute leukemia after the second dose. 

The case ended fatally. Careful testing for 

toxic reactions is urged. 

1586 

Abbo, F. IL CUORELEUCEMICOIN TRATTAMENTO 

AMINOPTERINICO. (CONTRIBUTOCLÃ•NICOE 

SPERIMENTALE). [THE HEART IN LEUKEMIC 

PATIENTS TREATEDWITH AMINOPTERIN. A 

CLINICAL ANDEXPERIMENTALCONTRIBUTION.] 

Minerva pediat., Tor.. 1954, 6: 399-407. 

17 refs. Abstracted In: Excerpta med.. 

Sect. 16, 1955, 3: No. 1342. 

1587 

Baserga, A. and Marinone, G. MEGAMYELOID CELLS 

AND AMINOPTERIN. (LETTER TO THE EDITOR) 

Lancet, Lond., 1949, 2: 1056. 3 refs. In 

mice, during acute intoxication with 4-aminopteroylglutamic 

acid, large myeloid cells 

with a budding nucleus appeared in the bone 

marrow while granuloblastic, erythroblastlc 

and megakaryocytic series almost completely 

disappeared. 

1588 

Baserga, A. and Marinone, G. SU UNA MODIFICAZIONE 

MENO NOTA DEL VILLO INTESTINALE NELL'INTOSSI 

CAZIONE DELLA CAVIA CON ACIDO 4-AMINO-PTEROIL- 

GLUTAMMICO. [A LITTLE-KNOWN CHANGE IN THE 

INTESTINAL VILLI IN GUINEA-PIGS POISONED WITH 

AMINOPTERIN.] Farmaco, Pavia, 1951, 6: 196- 

199. 

Sect. 

10 refs. 

2, 1951, 


4: No. 5409. "After 0.25-2.5 

mg/kg/day of amTnopterin for 5-25 days, the 

histiocytes of the axis of the villus are 

crowded with granules of an iron-containing 

pigment. This phenomenon is limited to the 

intestinal mucosa and does not 

due to haemorrhagic lesions of 

appear to be 

the intestine." 


1589 

Creveld, S. van, Paulssen, M. M. P. and Teng, 

S. K. DE OORZAAK VAN BLOEDINGEN TIJDENS HET 

GEBRUIK VAN AMINOPTERINE. [THE MECHANISM 

OF HAEMORRHAGE DUE TO 

Ned. tschr. geneesk., 

AMINOPTERIN THERAPY.] 

1951, 95: 374-377. 

tab. 10 refs. English summary. Abstracted 

in: Excerpta 

"The changes 

med., Sect. 7, 1951, 5: No. 

in plasma Ac-globulin after 

2858. 

ad 

ministration of aminopterin were studied in 

two patients. The conclusion is drawn that 

decrease of this clotting factor is very 

probably the cause of the obscure haemorrhages 

occurring often during this treatment."



90 

GLUTAMIC ACID, 4-AÃ•DNOPTEROYL-, â€”¿ TQXICITY 

(Continued) 

1590 Creveld, S. van, Paulasen, M. H. P. and Teng, 

S.U. ON A CAUSE OF HAEMORRHAGES DURING 

TREATMENT WITH AMINOPTERIN. Acta physiol. 

pharm. neerl., 1950, 1.:651-55. 8 reÃs. 

"From observations on two patients...one of 

the causes of haemorrhages after adminis 

tration of aminopterin 

plasma Ac-globulin." 

is a decrease of 

1591 

Goldin, A., Greenspan, E. M., Goldberg, B. and 

Schoenbach, E. B. STUDIES ON THE MECHANISM 

OF ACTION OF CHEMOTHERAPEUTIC AGENTS IN CANCER. 

I. A SEX DIFFERENCE IN TOXICITY TO THE FOLIC 

ACID ANALOGUE, 4-AMINOPTEROYLGLUTAJUC ACID. 


Abstracted in: Chem. Abstr., 1950, 44: No. 

10932b. 

1592 

Higglns, G. M. THE EFFECT OF FOLIC ACID ON THE 

TOXICITY OF ITS ANALOGUE 4-AMINOPTEROYLGLUTA- 

MIC ACID(AMINOPTERIN). Blood, Bait., 1949, 

4: 1142-1155. 13 refs. 

1593 

Lewis. J. T., Rabasa, S. L., Ferrer, J. and 

Dominico, A. D. ACTION DE L'ACIDE 4-AMINO- 

PTEROGLUTAMIQUE, AMINOPTÃ‰RINE, CHEZ LE RAT. 

1953, 

[EFFECT 

24: 

OF 

599-600. 

AMINOPTERIN 

Histopathologica'l 

IN RAT.] Sang, 

study 

Par., 

of acute" and chronic intoxication produced 

by a single intraperitoneal injection of 

100-800 mg of aminopterin per 100 g of weight 

in 121 male and 83 female mice. 

1594 

Lewis. J. T., Rabasa, S. L. and Ferrer, J. 

EFECTO DE LAS PEQUERAS DOSIS REPETIDAS DE 

ACIDO 4-AMINOPTEROILGLUTAMICO (AMINOPTERIN) 

EN RATAS NORMALES Y SUPRARRENOPRIVAS. [EF 

FECT OF REPEATED SMALL DOSES OF AMINOPTERIN 

IN NORMAL AND ADRENALECTOHIZED RATS.] 

Rev. soc. argent, biol., 1952, 28: 62-83. 

45 refs. English summary. French trans 

lation in: C. rend. Soc. biol., Paris., 

1953, 147: 142-146. 

1595 

Minnich, V., Moore, C. V., Smith, D. E. and 

Elliott. G. V. THE ACUTE TOXIC EFFECTS OF 

4-AMINOPTEROYLGLUTAMIC ACID IN DOGS, GUINEA 

PIGS, AND RABBITS. DIFFERENCE IN SPECIES 

SUSCEPTIBILITY AND PROTECTIVE ACTION OF FOLIC 

ACID. A.M.A. Arch. Path., 1950, 50: 787- 

799. 

1596 Pershin, G. N. and Dolgusheva, A. N. ANTI- 

FOLIEVAIA KISLOTA V MIKROBIOLOGICHESKOM 

EKSPERIMENTE. [FOLIC ACID ANTAGONIST IN 

MICROBIOLOGIC EXPERIMENT.] Biokhimiia, 

Moskva, 1952, 17: 339-342. 5 refs. The 

antifone acid~T2,4-diamino-6-pteridylmethylaminobenzolglutamic 

acid) decreased 

the growth of Streptococcus faecalis 

strains. The compound is very toxic; 1 Â»g 

was lethal for white mice. Test for pos 

sible anti-leukemic properties is suggested. 

15philips, F. S. and Thiersch, J. B. STUDIES OF 

THE ACTIONS OF 4-AMINO-PTEROYLGLUTAMIC ACID 

IN RATS AND MICE. J. Pharm. Exp. Ther., 



Chem. Abstr., 1949, Â«: 4768b. 

1598 Philips, F. S., Thiersch, J. B. and Ferguson, 

F. C. STUDIES OF THE ACTION OF 4-AMINO 

PTEROYLGLUTAMIC ACID AND ITS CONGENERS IN 

MAMMALS. Ann. N. York Acad. Sc., 1950, 52: 


Abstr., 1950, 44: 10835d. 

1599 

Ritter, H. B. 

IN WEANLING 

and Oleson, J. J. ACUTE LESIONS 

RATS FED 4-AMINOPTEROYLGLUTAMIC 

ACID. A.M.A. Arch. Path., 1949, 47: 435- 

439. pi. 7 refa. 

16Sansone, G. EMBRIOPATIE SPERIMENTALI DA DE 

FICIENZA DI ACIDO FOLICO NELL RATTO, PRO 

DOTTE MEDIANTE SOMMINISTRAZIONE DI AMINO- 

PTERINA. [EXPERIMENTAL EMBRYOPATHOLOGY AS 

A RESULT OF FOLIC ACID DEFICIENCY IN THE 

RAT, PRODUCED WITH AMINOPTERIN.1 Boll. Soc. 

ital. biol. sper., 1953, 29: 1697-1699. 

5 refs. Abstracted in: CEern. Abstr., 1954, 

48: 8949d. 

1601 

Sansone, G. PATHOMORPHOSIS OF ACUTE INFANTILE 

LEUKAEMIA TREATED WITH MODERN THERAPEUTIC AGENTS- 

'MENINGOLEUKAEMIA' AND FRÃ–HLICH'S OBESITY. Ann. 

paediat., Basel, 1954, 183: 33-42. Report of 

neurological complications in two cases of acute 

infantile leukaemia treated with aminopterin 

and or cortisone. "The symptomatic complex 

Â«ccurred in patients with the longest remission 

and with a normal bone marrow and was charac 

terized by an obesity of FrOlich's type and a 

variety of meningoencephalic 

level of "blast cells" could 

signs. A high 

be demonstrated in 

the spinal fluid of both patients." 

1602 

Swendseid, M. E., Swanson, A. L., Meyers, M. C. 

and Bethell, F. H. THE NUTRITIONAL STATUS IN 

PERSONS WITH LEUKEMIA AND ITS POSSIBLE RELA 

TION TO EFFECTS OF AMINOPTERIN THERAPY. 


1603 

Waisman, H. A., Richmond, J. B. and Zimmerman, 

A. A. HYPERPIGMENTATION IN ACUTE LEUKEMIA 

TREATED WITH FOLIC ACID 

Soc. Exp. Biol., N. Y., 

ANTAGONISTS. Proc. 

1950, 75: 332-334. 

Abstracted in: Chem. Abstr., 1951, 45: 1686e; 

Biol. Abstr.., Bait., 1951, 25: No. 13814. 

1604 

Wilson, S. J., Coxsey, L. and Bossi, C. DE 

VELOPMENT OF MACROCYTIC ERYTHROCYTES IN LEU- 

KEMIC SUBJECTS RECEIVING FOLIC ACID ANTAGONIST, 

4-AMINOPTEROYLGLUTAMIC ACID (AMINOPTERIN). 

Proc. Soc. Exp. Biol., N. Y., 1949, 71: 11-13. 


1605 

Woll, E. and Oleson, J. J. THE EFFECTS OF A 

FOLIC ACID ANTAGONIST(AMINOPTERIN) ON ALBINO 

RATS: 

Brit. 

A STUDY 

J. Exp. 

IN THE 

Path., 

PATHOGENESIS OF SPRUE. 

1951, 32: 458-461. 

2 pi. 4 refs. Abstracted In: Excerpta med., 

Sect. 5, 1952, 5J No. 2020. 

See 

229 1418 1570 1578 1612 


1606 

Barnard, R. D. and Freeman, M. D. AMINOPTERIN 

TOXICITY REVERSAL BY A HEMOPOIETIC FRACTION 

OF MICROBIAL ANIMAL PROTEIN FACTOR: SOME 

SIMILARITIES OF STREPTOMYCES FERMENTATION 

RESIDUE TO PITUITARY ERYTHROPOIETIN. Am. J. 

Digest. Dis., 1955, 22; 76-82. 40 refs. 

Barnard, R. D. and Freeman, M. D. REVERSAL OF 

AMINOPTERIN TOXICITY BY WATER-SOLUBLE CUPRI- 

DIHYDROPORPHYRINS (CHLORESIUM). Am. J. Digest. 

Dis., 1954, 21: 163-169. 17 refs.



91 

GLUTAMIC ACID, 4-AMINOPTEROYL-, â€”¿ TOXICITY, 

COUNTERACTION TO (Continued) 

1608 

Baumann, C. A. CITROVORUM FACTOR; NUTRITIONAL 

ASPECTS, 

ANEMIA. 

ASSOCIATIONS 

J. Am. Diet. 

WITH LEUKEMIA AND 

Ass., 1953, 29: 548- 

554. 81 roÃ.s, 

1609 

Benard, H., Rambert, P. and Dantchev, D. ACTION 

DE L'AMINOPTÃ‰RINE SUR L'HÃ‰MATOPOIÃˆSEDES RATS 

SOUMIS A L'ACTION DE LA VITAMINE B12 DE L'ACIDE 

FOLIQUE ET DE L'EXTRAIT HÃ‰PATIQUE. [EFFECT OF 

AMINOPTERIN ON HEMOPOIESIS OF THE RAT AFTER 

ADMINISTRATION OF VITAMIN B12. FOLIC ACID AND 

LIVER EXTRACT.] Sang, Par., 1953, 24: 372-378. 

30 refs. 

1610 

Boyd, E. M. THE NEUTRALIZATION OF AMINOPTERIN- 

INDUCED JÊUKOPENIA BY ADENOSINE-5-PHOSPHORIC 

ACID. J. Laborat. Clin. M., 1953, 41: 931- 

935. 15 refs. Abstracted io: Excerpta mod., 

Sect. 16, 1954, 2: No. 4334; Leukemia Abstr., 

1953, 1: No. 289. Simultaneous administra 

tion oT adenosine-5-phosphoric acid prevented 

development of leukopenia in guinea pigs in 

duced by aminopterin but did not lower mortal 

ity rate. 

1611 Consoli, G. SUR LE TRAITEMENT ASSOCIÃ‰CITRO 

VORUM FACTOR-AMINOPTKHINE DANS LES LEUCÃ‰MIES 

AIGUÃ‹S. [ASSOCIATED CITROVORUM FACTOH-AMINO- 

PTERIN TREATMENT IN ACUTE LEUKEMIA.] 

Par., 1955, 26: 426-434. 22 refs. 

Sang, 

1612 

De Renzo, E. C. and Dessau, T. I. PREVENTION 

OF BONE-MARROWAPLASIA INDUCEDBY AMINOPTERIN 

WITH FOLACIN ANDFOLINIC ACID. Proc. 

Exp. Biol., N. Y., 1954, 86: 231-233. 

Soc. 

12 refs. 

1613 Dustin, P. Jr. PROTECTION, PAR LE 'FACTEUR 

CITROVORUM' DES MITOSES INTESTINALES VIS-X- 

VIS DE L'ACTION RADIOMIMÃˆTIQUE DE L'AMINO- 

PTÃ‰RINE. [PROTECTION BY CITROVORUM FACTOR 

AGAINST THE RADIOMIMETIC ACTION OF AMINO 

PTERIN ON INTESTINAL MITOSES.] C. rend. 

Soc. biol., 1951, 145: 1442-1443. Abstracted 

in: Excerpta med., "Sect. 2, 1952, 5: No. 4514. 

1614 

Ershoff, B. H., HoffStadt, J. P. and McWilliams, 

H. B. EFFECTS OF FOLIC ACID ON AMINOPTERIN 

TOXICITY IN THE IMMATURE 

Exp. Biol., N. Y., 1950, 

MOUSE. Proc. 

73: 501-503. 

Soc. 

8 refs. 

1615 

Goldin, A., Greenspan, E. M., Venditti, J. M. 

and Schoenbach, E. B. STUDIES ON THE BIO 

LOGICAL INTERRELATIONSHIPS OF FOLIC ACID, 

CITROVORUM FACTOR, AND THE ANTMETABOLITE, 

AMINOPTERIN. J. Nat. Cancer lust,, 1952, 

12^: 987-1002. 24 refs. 

1616 Goldin, A., Mantel, N., Venditti, J. M. and 

Greenhouse, S. W. AN ANALYSIS OF DOSE- 

RESPONSE FOR ANIMALS TREATED WITH AMINOPTERIN 

AND CITROVORUM FACTOR. J. Nat. Cancer Inst., 

1953, 13: 1463-1471. 13 refs. 

1617 

Greenspan, 

STUDIES 

E. M., Goldin, A. and Schoenbach, E. 

ON THE MECHANISM OF ACTION OF CHEMO- 

B. 

THERAPEUTIC AGENTS IN CANCER. II. REQUIRE 

MENTS FOR THE PREVENTION OF AMINOPTEHIN TOXICITY 

BY FOLIC ACID IN MICE. Cancer, N. Y., 1950, 

3: 856-863. 14 refs. Abstracted in: Chem. Abstr., 

T950, 44: No. 10932b. 

1618 

Greenspan, E. M., Goldin, A. and Schoenbach, E. B. 

STUDIES ON THE MECHANISM OF ACTION OF CHE1IO- 

THERAPEUTIC AGENTS IN CANCER. V. INFLUENCE 

OF THE CITROVORUM FACTOR AND FOLIC ACID ON 

THE TOXIC MANIFESTATIONS OF AMINOPTERIN IN 

MICE. Cancer, N. Y., 1951, 4: 619-625. 29 

refs. 

[1619 not used] 

1620 

Kieler, J. COMBINATION THERAPY OF CHLOROLEU- 

KEMIA IN MICE 

FACTOR. Acta 

WITH AMINOPTERIN AND CITROVORUM 

haemat., Basel, 1953, 10: 180- 

185. 21 refs. Abstracted in: LeukemTa Abstr., 

1621 

Lewis, J. T., Rabasa, S. L. and Domenico, A. D. 

EFECTO DE LA CORTISONA Y LA DOCA SOBRE LA 

INTOXICACIÃ“N POR EL ACIDO 4-AMINOPTEROILGLU- 

TAMICO EN RATAS NORMALES Y SUPRARENOPRIVAS. 

[EFFECT OF CORTISONE AND DOGA ON INTOXICATION 

BY 4-AMINOPTEROYLGLUTAMIC ACID IN NORMAL AND 

ADRENALECTOMIZED RATS.] Rev. Soc. argent, 

biol., 1952, 28: 93-102. tab. 6 refs. 

English summary. French translation 

rend. Soc. biol., Paris, 1953, 147: 

in: C. 

150-152. 

Abstracted 

8: No. 85. 

in: Excerpta ned., 

"The toxic effect 

Sect. 3, 1954, 

of aminopterin 

In adrenalectomized rats was not counteracted 

by the administration 

DOGA..." - Excerpta 

of cortisone 

mod. 

and/or 

1622 

Rabasa, S. L., Bergmann, F. and Domenico, A. D. 

EFFECT OF DCA AND NACL LOADING ON AMINOPTERIN 

INTOXICATION AND WEIGHT OF THYMUS. Endocrino 

logy, 1954, 54: 483-490. 11 refs. 

1623 

REVERSAL OF AMINOPTERIN TOXICITY IN THE RAT. 

Nutrit. Rev., 1953, 11_: 348-350. A review. 

1624 

Sauberlich, H. E. STUDIES ON THE REVERSAL OF 

AMINOPTERIN TOXICITY IN THE RAT WITH CITRO 

VORUM FACTOR, FOLACIN 

J. Nutrii., Ã•953, 50: 

AND RELATED COMPOUNDS. 

101-115. 30 refs. 


0~.75 2: No. to 3839. 1.0 rag/kg Aminopterin diet was fed toxic at to a level weanling 

rats. Daily injections of 2.5|ig of leucovorin 

(synthetic citrovorum factor) gave 

partial protection, 100 pg full protection, 

while 250 u.g of folacin was essentially In 

effective. Full protection was afforded by 

5 to 10 mg of CF or by 100 mg of folacin per 

kilogram of diet. Ascorbic acid, aureomycin 

and penicillin were without benefit. Corti 

sone with limiting amounts of CF gave some 

protection. 

1625 

Schoenbach, E. B., Greenspan, E. M. and Colsky, 

J. REVERSAL OF AMINOPTERIN AND AMETHOPTERIN 

TOXICITY BY CITROVORUM 

1950, 144: 1558-1560. 

FACTOR. 

7 refs. 

J. Am. M. Ass., 

Two patients 

treated with amethopterin or aminopterin for 

metastatic neoplasm, developed leukopenia and 

ulcerated mouth lesions. After administration 

of citrovorum factor, without discontinuance 

of the folie acid antagonist, these toxic 

manifestations disappeared. The citrovorum 

factor, unlike folie acid, not only prevents 

but reverses established toxic manifestations. 

1626 

Â»Traina, V. ADRENOTROPIC HORMONE (ACTH), AMINO 

PTERIN AND EOSINOPHIL COUNT. Nature, Lond., 

1951, 168; 250. 

1627 

Traina, V. RECIPROCAL DETOXIFYING EFFECTS OF 

'BENADRYL' AND 'AMINOPTEHIN'. Nature, Lond., 

1950, 166: 158. 13 refs.



92 

GLUTAMIC ACID, 4-AMINOPTEROYL-, â€”¿ TOXICITY, 

COUNTERACTION TO (Continued) 

See 

Waisman, H. A. and Cravioto, II. J. FURTHER 

ROLE OF ANTIBIOTICS IN AMINOPTERIN-INDUCED 

FOLIC ACID DEFICIENCY IN RATS. Proc. Soc. 

Exp. Biol., N. Y., 1952, 79: 525-527. 

3 reÃs. Streptomycin, terramycin, peni 

cillin and chloromycetin did not overcome 

the deficiency induced by the feeding of 

aminopterin to rats nor did citrovorum 

factor counteract aminopterin at low levels, 

suggesting that aminopterin may be a citro 

vorum factor antagonist. 

1426 1459 1547 

GLUTAMIC ACID, 4-AMINOPTEROYL 

DERIVATIVES 

1629 Soothe, J. H. L'ACIDE PTÃ‰ROYGLUTAMIQUE[SIC] 

ET SON UTILISATION DANS LE TRAITEMENT DU 

CANCER. [PTEROYLGLUTAMIC ACID AND ITS USE 

IN THE TREATMENT OF CANCER.] Rev. path, 

comp., Par., 1949, 49: 283-285. 13 refs. 

Very short review. 

1630 

Szabo, Z. FOLSAV ANTAGONISTAK. [FOLIC ACID 

ANTAGONISTS.] Orv. Hetil., 1951, 92: 1039- 


1631 

Dustin, P., Jr. LÃ‰SIONS CELLULAIRES PROVOQUÃ‰ES 

PAR LES ACIDES 4-AMINOPTEROYLGLUTAMIQUES CHEZ 

LA SOURIS. [CELL LESIONS PROVOKED BY 4-AMINO- 

PTEROYLGLUTAHIC ACID IN THE MOUSE.] Rev. 

hÃ©mat., Par., 1950, 5: 603-617. 34 refs. 

1632 

Thiersch, J. B. and stock, C. C. BONE MARROW 

OF MICE BEARING SARCOMA 180 TREATED WITH 4- 

AMINO-PTEROYLGLUTAMIC ACID AND WITH 4-AMINO- 

N10-METHYL-PTEROYLGLUTAMIC ACID. Cancer, N. Y., 


Biol. Ibstr., Bait., 1950, 2Â£: No. 1776. 

1633 

Wagley, P. F. and Morgan, H. R. EFFECTS OF 

FOLIC ACID ANTAGONISTS INOCULATED IN EMBRYO- 

NATED EGGS. Arch. Path., Chic., 1949, 46: 

441-450. 16 refs. Abstracted in: Chen. 

Abstr., 1949, 43: 7097b. 

See 

3372 EFFECT 


1634 

Â«Baserga, A. LE ANTIVtTAMINE DAL PUNTO DI VISTA 

DELLA 

GICAL 

PATOLOGIA E DELLA CLÃ•NICA. [TBS PATHOLO 

AND CLINICAL SIGNIFICANCE OF ANTI-VITA 

MINS.] 96 p. Roma, Consiglio Nazionale delle 

Ricerche, 1953. Abstracted 

1953, 1: No. 312. "In that 

in: Leukemia Abstr., 

part of the paper 

(pp. 66-87) which is devoted to pathogenic and 

cytostatic effects of antifolics, experimental 

and clinical studies of the properties of ami 

nopterin, amethopterin and related substances 

are described. Animal experiments (mostly on 

mice) were concerned with toxic effects of 

antifolics and the accompanying changes in the 

blood diagram (reduction of leukocytes), the 

bone marrow (aplasia and appearance of giant 

cells), lymphopoiesis, and tissues of the 

intestine (chromosome alterations). In clini 

cal observations 12 patients (mostly children) 

were submitted to combined treatment by anti 

folics, X-irradiation and blood transfusions..." 


See 

141MODE OF 3372ACTION 

1635 

Skipper, H. E. MECHANISMS OF ACTION OF CERTAIN 

AGENTS WITH ANTI-CANCER ACTIVITY. Texas 

Rep. Biol. M., 1952, 10: 1055-1061. 10 refs. 

See 

1364 RESISTANCE TO 

1636 

Burchenal, J. H., Babcock, G. M., Armstrong, 

R. A. and Robinson, E. MECHANISM OF RESIS 

TANCE IN LEUKEMIA. Acta UniÃ³ internat, cancr., 

Louvain, 1951, 7: 436-442. 44 refs. "Resis 

tance to 4-amino-NlO-methyl-PGA (A-methopterin) 

has been developed in a strain of mouse leuke 

mia hitherto sensitive to this drug. This 

resistance has remained despite twenty passages 

through untreated mice. Cross resistance ex 

tends to all other 4-amino derivatives of PGA 

so far tested but not to a methyl antagonist 

of PGA. 2,6-diaminopurine, an adenine anta 

gonist is active against this A-methopterin 

resistant leukemia. The most likely mechanism 

for this resistance is an ability of the re 

sistant cell to deaminate, methylate, acetylate, 

or esterify the 4-amino group of the A-methop 

terin molecule." 

1637 

La w. L. W. STUDIES ON TRANSFORMATIONS TO RE 

SISTANCE AND DEPENDENCE IN LEUKEMIC CELLS. 

In: Origins of resistance to toxic agents; 

proceedings of the symposium held in 

Washington, D. C., March 25-27, 1954 

(Sevag, M. G., Reid, R. D. and Reynolds, 

0. E.. eds.) 

p. 268-286. 

New York, 

41 refs. 

Academic Press, 1955 

THERAPY 

1638 

Branche, G. C., Jr., Downing, V., Homburger, F. 

Shen, S. C. and Zamcheck, N. OBSERVATIONS 

ON TEN PATIENTS WITH GASTROINTESTINAL CANCER 

DURING THE COURSE OF CHEMOTHERAPY WITH DI- 

CHLOROAMINOPTERIN. 

6: 760-764. rÃ©f. 

Cancer, Phila., 1953, 


Abstr., 1953, 47: No. 10744a; Excerpta med., 

Sect. 16, 1954, 2: No. 1310. 

1639 

Burchenal, J. H., Karnofsky, D. A., Kingley- 

Pillers, E. M., Southam, C. M., Myers, W. P. L., 

Escher, G. C., Graver, L. F., Dargeon, H. W. 

and Rhoads, C. P. THE EFFECTS OF THE FOLIC 

ACID ANTAGONISTS AND 2:6-DIAMINOPURINE ON 

NEOPLASTIC DISEASE, WITH SPECIAL REFERENCE 

TO ACUTE 

549-569. 

LEUKEMIA. 

103 refs. 

Cancer, N. Y., 1951, 4: 


med., Sect. 5, 1952, 5: No. 2700; Chem. Abstr., 

1951, 45: 8148a. 

164.0 

Dameshek, W., Freedman, M. H. and Steinberg, L. 

FOLIC ACID ANTAGONISTS IN THE TRBATMSNT OF 

ACUTE AND SUBACUTE LEUKEMIA. Blood, Bait., 

1950, 5: 898-915. 2 pi. 13 rÂ«fs. Abstracted 


Biol. Abstr., Bait., 1951, 25; No. 817Â».



93 

GLUTAMIC ACID, 4-AMDÃOPTEROYL DERIVATIVES â€”¿ 

THERAPY (Continued) 

1641 Dustin, P., Jr., Henry, J. A. and Peltzer, T. 

OBSERVATIONS SUR LES EFFETS CHIMIOTHÃ‰RAPIQUES 

DES ACIDES 4-AMINO-PTEROYLGHTÂ»Â»"Q"]ÃŽSDANS LES 

LEUCEMIES A CELLULES PEU DIFFERENCIEES ET A 

Â¿VOLUTION AIGUÃ‹. [OBSERVATIONS ON THE CHEMO- 

THERAPEUTIC EFFECTS OF 4-AMINOPTEROYLGLUTAMIC 

ACIDS IN ACUTE AND 

KEMIA.] Bruxelles 

UNDIFFERENTIATED 

mÃ©d., 1953, 33: 

CELL LEU 

547-575. 

37 rets. The results of oral treatment with 

aminopterin and amethopterin in 33 cases 

during a peroid of two years are reported. 

1642 Freedman, M. H. FOLIC ACID ANTAGONISTS IN THE 

TREATMENT OF ACUTE AND SUBACUTE LEUKEMIA. 

J. M. Ass. Georgia, 1951, 40: 177-180. 9 reÃs. 

A review. 

1643 Fustinoni, 0. and Lascalea. M. C. LOS ANTA 

GONISTAS DEL Ã•CIDOFÃ“LICÃ“EN EL TRATAMIENTO 

DE LAS LEUCEMIAS. [FOLIC ACID ANTAGONISTS 

IN THE TREATMENTOF LEUKEMIA.] Prensa med. 

argent., 1950, 37: 1992-1996. 8 refs. 

16jicobson, W., Levin, W. C. and Holt, G. OB 

SERVATIONS ON THE TREATMENTOF ACUTELEUCE 

MIAS WITH ANALOGUESOF FOLIC ACID. J. 

Laborat. Clin. M., 1948, 3jJ: 1641-1642. 

1645 Malaguzzi-Valeri, O. and De Benedetti, R. G. 

SUL TRATTAMENTO CON ANTIFOLICI E CON ACTH 

DELLE LEUCEMIE INFANTILI. [TREATMENT OF 

INFANTILE LEUCEMIAS WITH ANTIFOLICS AND 

ACTH.] Riv. clin, pediat., 1953, 51: 532- 

536. 

1646 

Maurea C. and Bissanti, A. GLI ANTIFOLICI 

NELLA TERAPIA DELLE LEUCEMIE ACUTE. [FOLIC 

ACID ANTAGONISTS IN THE TREATMENT OF 

LEUKEMIA.] Progr. med., Nap., 1951, 

ACUTE 

7: 79- 

86. 44 refs. A review. 

1647 Messerschmitt, J. ANTAGONISTI DELL'ACIDO FOLICO 

(ACIDO PTEROILGLUTAMICO) . [FOLIC ACID ANTAGO 

NISTS 

1949, 

(PTEROYLGLUTAMIC 

15_: 105-108. 

ACID).] Athena, Roma, 

1648 Thiersch, J. B. and Philips, F. S. FOLIC ACID 

AND ANTAGONISTSIN NEOPLASTIC DISEASE. Am. 

J. M. Se., 1949, 217: 575-585. 97 refs. 

A review. 

See 

566 1294 1634 2332 2384 

-TOXICITY 

1649 

Thiersch, J. B. BONE-MARROW CHANGES IN MAN AFTER 

TREATMENT WITH AMINOPTERIN, AMETHOPTERIN, AND 

AMINO-ANFOL; WITH SPECIAL REFERENCE TO MEGALO- 

BLASTOSIS AND TUMOR REMISSION. Cancer, N. Y., 

1949, 2: 877-883. 12 refs. 


1650 

Earle, A. M., Reilly, W. A. and Lawson, W. G. 

CITROVORUM FACTOR IN LEUCEMIA. TWO CASES 

WITH AUTOPSY FINDINGS. J. Pediat., S. Louis, 

1951, 39: 560-564. 5 refs. Clinical and 

autopsy findings in two cases of leukemia 

showed that the toxic effects of aminopterin 

and amethopterin were temporarily suppressed 

by citrovorum. The effects of the citrovorum 

factor were thought to be due to a general 

inhibition of the antifolic acid compounds. 

1637 

GLUTAMIC ACID, 7-METHYLPTEROYL- 

See 

3500 

1651 

Burchenal, J. II,,, Johnston. S. F. and Waring, G. B. 

MECHANISMSOF AMEÃ•HOPTERINRESITANCE IN LEUKEMIA. 

I. EFFECTS OF WEAKFOLIC ACID ANTAGONISTSON 

MOUSELEUKEHIAS. 

1951, 78: 348-351. 

Proc. Soc. 

20 refs. 

Exp. Biol., 

Abstracted 

N. 

in: 

Y., 


GLUTAMIC ACID, X-METHYLPTEROYL 

1 652 

Goldsmith, E. D., Black, H. M. and Nigrelli, 

H. F. INTERFERENCE WITH TESTOSTERONE -INDUCED 

GROWTH OF THE SEMINAL VESICLES AND COAGULATING 

GLANDS IN MALE MICE BY A FOLIC ACID ANTAGONIST. 


1653 

Â«Salis, H. ERYTHROPHAGOCYTOSIS IN BONE MARROW 

CULTURE WITH RELATION TO ANTAGONISM OF PTEROYL 

GLUTAMIC ACID. Proc. Soc. Exp. Biol., N. Y., 

1948, 68: 382-385. 

GLUTAMIC ACID, 

GLUTAMIC ACID, 9-METHYLPTEROYL- 

PTEROYLDI- 

1654 

Conte Marotta, R. LA "TEROPTERINA" E LA 

"DIOPTERINA" NELLA CURA DEL CANCRO. [TEROPTERIN 

AND DIOPTERIN IN THE CURE OF CANCER]. Progr. 

med. Nap., 1948, 4: 440-441. 

COUNCIL ON PHARMACY AND CHEMISTRY. REPORT: 

"TEROPTERIN" AND "DIOPTERIN" IN THE TREATMENT 

OF CANCER. J. Am. M. Ass., 1948, 137: 699- 

700. 6 refs. 

Farber, S., Cutler, E. C., Hawkins, J. W., 

Harrison, J. H., Peirce, E. C. and Lenz, G. G. 

THE ACTION OF PTEROYLGLUTAMIC CONJUGATES ON 

MAN Science, 1947, 106: 619-621. 8 refs. 

Abstracted in: Chem. Abstr., 1948, 42: 2016h> 

Biol. Abstr., Bait., 1948, 22: No. T3~832. 

1657 Gilmore, J. R. REPORT OF THE USE OF PTEROYL- 

TRIGLUTAMIC AND PTEROYLDIGLUTAMIC ACID AT 

THE GRACE HOSPITAL TUMOR CLINIC. Grace 

Hosp. Bull., 1950, 28: 63-68. 6 refs. 

1658 Rocchietta, S. AZIONE ANTICANCEROSA DI ALCUNI 

DERIVATI DELL'ACIDO FOLICO. [ ANTI NEOPLASTIC 

EFFECT OF SOME FOLIC ACID DERIVATIVES.] 

Minerva med., Tor., 1948, 39: pt. 2, 242. 

See 

TEROPTERIN AND DIOPTERIN. EVALUATION OF RESULTS 

IN TREATMENT OF CANCER ISSUED BY THE A.M.A.'S 

COUNCIL ON PHARMACY AND CHEMISTRY. J. Am. 

Pharm. Ass. Pract. Pharm. Ed., 1948, 9: 407- 

4O9. 6 refs. An editorial. 

1385 

GLUTAMIC ACID, PTEROYLTRI-, 

GROWTH 

See 

1395 

_ 

â€”¿EFFECTON NORMAL



94 

GLUTAMJC ACID, PTEROYLTRI-, â€”¿ EFFECT 

TUMOR GROWTH 

1660 

Eser, O. TEROPTERIN'NIN WALKER TÃœMÃ–RÃœÃœZERINE 

TESIRI. [EFFECT OF TEROPTERIN ON WALKER 

TUMORS.] Tip 

14: 334-336. 

Fak. meomuasi, Istanbul, 1951, 

8 reÃs. English summary. 

"7..teropterin produced no effects in al 

bino rats bearing transplanted tumors of 

Walker. 

noted in 

No bistological...changes 

tumor tissue." 

were 

1661 

Trasino, II. and Pardo, G. L. RICERCHE SPERI 

MENTALISULL'AZIONE DEI COMPOSTIDELL'ACIDO 

FOLICO SUI TUMORI. [EXPERIMENTSON THE 

ACTION OF FOLIC ACID COMPOUNDSON TUMORS.] 

Boll. Soc. ital. Biol. sper., 1949, 25: 

874-876. Abstracted in: Chem. AbstrT, 1951 

45: 72421)_ 

See 

1009 1385 3247 

ON 

METABOLISM 

1662 

Toennies, G. and Gallant, D. L. BACTERIMETRIC 

STUDIES. III. BLOOD LEVEL STUDIES ON TERO 

PTERIN METABOLISM. J. Laborat. Clin. M., 

1949, 34: 501-508. 11 reta. 

THERAPY 

1663 

Bertiglia, B. PRIME ESPERIENZE SULL'USO DEL 

TEROPTERIN IN ALCUNI NEOPLASMI. [THERAPY 

OF VARIOUS NEOPLASMS WITH TEROPTERIN; FIRST 

RESULTS.] Bull, 

111: 313-316. 

sc. mod., Bologna, 1949, 

1664 

Blum, R. THE USE OF TEROPTERIN IN MALIGNANT 

DISEASE. Bull. M. Soc. Co. Erie, 1949, 26: 

No. 1, 11, 30. 

1665 

Brahin, C., Ritz, N., Krim, M. and Meyer, L. M. 

REMISSION IN CHRONIC MYELOCYTIC LEUKEMIA DUR 

ING FOLIC 

1954, 54: 

ACID THERAPY. N. York 

1371-1372. 11 refs. 

State J. II., 

1666 

Brockman, G. F., and Simpson, G. L. TEROPTERIN, 

PTEHOYL-TRIGLUTAMIC ACID IN HUMAN CANCERS; 

PRELIMINARY REPORT. Kentucky 

46: 309-311. From experience 

M. J., 

in six 

1948, 

cases 

treated solely with Teropterin and in other 

cases treated with Teropterin and other forms 

of treatment, it was concluded that any bene 

fit to the patient from Teropterin is euphor 

ic, not analgesic and not curative. 

1667 

Capra, P. L'ATTIVITÃ€ ANTINEOPLASTICA DI DERI 

VATI E ANTAGONISTI DELL'ACIDO FOLICO. Ã•ANTI- 

NEOPLASTIC EFFECT OF DERIVATIVES AND ANTAGO 

NISTS OF FOLIC ACID.] Riforma med., 1949, 

63: 250-254. 27 refs. 

1668 

FernÃ¡ndez Cruz, A. EL ACIDO FOLICO Y SUS DERI 

VADOS COMO AGENTES TERAPÃ‰UTICOS EN EL TRA 

BAMIENTO DE CIERTAS ENFERMEDADES NEOPLÃ‚SICAS, 

ASI COMO DE LAS LEUCEMIAS HUMANAS. [FOLIC 

ACID DERIVATIVES AS THERAPEUTIC AGENTS IN 

THE TREATMENT OF SOME NEOPLASTIC. DISEASES AND 

HUMAN LEUKEMIAS.l 

9: 87-88. 

Farm, b ter., Madr., 1948, 

1669 

Hardy, S. M., Joyner, A. L. and Howard, R. W. 

A REPORT ON THE USE OF SODIUM PTEROYL TRI- 

GLUTAMATE 

1949, 49: 

IN 413 CASES. N. York 

2697-2698. 6 refs. 

State J. M., 

1670 

Hedenius, P. TEROPTERINTERAPI VID INOPERABLA 

MALIGNA LUNGTUMÃ–RER. [TEROPTERIN THERAPY OF 

INOPERABLE MALIGNANT LUNG TUMORS.] Nord, med., 


12 cases. 

1671 Khosla. H. L. and Das-Gupta, A. A CASE OF 

ACUTELYMPHATICLEUKAEMIAIN AN ADULTTREATED 

WITH ANTIFOLIC ACID SUBSTANCE. Ind. M. Gaz., 


Leukemia Abstr., 1954, 2: NÂ«. 591. 

1672 

Â«Klainer, M. J. A CASE REPORT OF METASTATIC 

CARCINOMA TREATED WITH TEROPTERIN. Tr N 

York Acad. Sc., 1947-1948, 10: 71-75. Also 

in: Ann. Int. M., 1948, 29:^149-1157. 

1673 

Lehv, S. P., Wright, L. T., Weintraub, S. and 

Arons, I. USE OF TEROPTERIN IN NEOPLASTIC 

DISEASE: A PRELIMINARY CLINICAL REPORT. Tr 

N. York Acad. Sc., 1948, 10: 75-81. 5 refs. 

1674 

Niemeyer, G. F. TEROPTERIN; SURVEY OF LITERA 

TURE ON NEW FOLIC ACID DERIVATIVE FOR USE IN 

-soc- Hos- Ph*â„¢-. 

1675 

Pricolo, V. A PROPOSITO DELLA 'TEROPTERIN" 

NELLA CURA DEL CANCRO. [TEROPTERIN IN THE 

TREATMENT OF CANCER.] 

23 Â¡l4J -l4-i, 

Tumori, Milano, 1949, 

1676 

Taylor, S. G., Slaughter, D., Preston, F. W., 

Crumrine, J. and Hass, G. EFFECT OF ANTI 

FOLIC ACID DERIVATIVES ON PATIENTS WITH 

FAR-ADVANCED CARCINOMATOSIS. Proc. Centr. 

Soc. Clin. Res., 1948, 2_1: 92-93. 

1677 

Weintraub, S., Arons, I., Wright, L. T., Andler, 

L. R., Prigot, A., Wright, J. C. and Lehv, 

S. P. AN EVALUATION OF TEROPTERIN THERAPY 

IN METASTATIC NEOPLASMS. N. York State J. M 

1951, 51: 2159-2162. 23 refs. Teropterin 

Â»as used in 102 cases of metastatic neoplasms; 

although there was subjective improvement in 

55 cases, no histological evidence of specific 

cellular changes or objective signs of improve 

ment were noted. 

1677a 

Higgins, G. M. and Woods, K. A. THE INFLUENCE 

OF THE ADRENAL GLAND ON SOME OF THE CHANGES 

INDUCED IN THE ANIMAL ORGANISMS BY THE FOLIC 

ACID ANALOGUE, AMINOTEROPTERIN. Proc. 

Clin., 1949, 24: 533-537. 8 refs. 

Mayo 

1654 1655 1656 1657 1658 

1659 TOXICITY 

1678 

Rossi, R. MODIFICAZIONI ISTOLOGICHE DEL FEGATO 

IN ANIMALI TRATTATI CON ACIDO PTEROILTRIGLU- 

TAMMICO. [HISTOLOGIC CHANGES OF THE LIVER IN 

ANIMALS TREATED WITH PTEOYLTRIGLUTAMIC ACID.] 

Riv. pat. clin., 1952, 7: 199-201. English 

summary. 

See 

1397 1656 

GLUTAMIC ACIDS 

1679 

Â«Bassi, M. AZIONE DELL'ACIDO'* -ABINOGLUTARICO 

E DELL'ACIDO L-GLUTAHMICO SU CULTURE 'IN 

VITRO' DI FIBROBLASTI DI POLLO. [INFLUENCE 

OF-rf -AMINO-GLUTARIC ACID AND L-GLUTAMIC 

ACID ON IN-VITRO CULTURES OF CHICK FIBROBLASTS.] 

Tumori, Milano, 1954, 40: 75-81. Abstracted 

in: Excerpta med., SecTT 16, 1954, 2: No. 4338.



95 

GLUTAMIC ACIDS (Continued) .if,;,-- - 

1680 

Bernard, J. LES ESSAIS DE TRAITEMENT DES LEUCOSES 

AIGUÃ‹S. [ATTEMPTED TREATMENTS OF ACUTE LEUKEMIA], 

Sem. h8p. Paris, 1950, 26: 3322-3335. 53 refs. 

1681 

Bernard, J. LES NOUVEAUX TRAITEMENTS DES LEU 

COSES AIGUÃ‹S (ANTIFOLIQUES. CORTISONE, A.C.T.H. 

ASSOCIATION AMINOPTERINE-CORTISONE). [NEW 

THERAPY OF ACUTE LEUKEMIA (FOLIC ACID ANTA 

GONISTS, CORTISONE, ACTH, AMINOPTERINE-CORTI 

SONE COMBINED).] Paris med., 1951, 41: 285- 

287. 15 refs. 

1682 

De GroÃ³te, J. BEHANDELING VAN LEVERCOMA MET 

GLUTAMINEZUUR. [GLUTAMIC ACID IN THERAPY 

OF CARCINOMA OF THE LIVER.] 

geneesk., 1954, 10: 230-242. 

Belg. tschr. 

40 refs. 

1683 

It8, S. and Shimogata, K. INHIBITORY EFFECT OF 

AN ISOMER OF PTEROYLGLUTAMIC ACID ON CELL PRO 

LIFERATION IN BONE-MARROW CULTURE. Vitamins. 

Japan, 1952, 5: 94-95. 2 refs. In Japanese. 

Abstracted in: Chem. Abstr., 1952, 46: 10218c. 

GLUTARIC ACID, ÃŸ-AMINO, 

see GLUTAMIC 

GLUTATHIONE 

See 

939 

GLYCINE 

ACIDS 

1684 Martinetto, G. INFLUENZA DELLA GLICINA SULL'ACCRES 

CIMENTO DELL'ADENOCARCINOMA TP.APIANTABILE. [EF 

FECT OF GLYCINE ON THE GROWTH OF TRANSPLANTED 

ADENOCARCINOMA.] Neoplasie b aliment., 1953, 

6: 297-303. 15 refs. A total of 300 mg of 

glycine injected subcutaneously into 30 male 

albino rats slightly inhibited the growth of 

adenocarcinoma and arrested cachexia, but had 

no effect on ulcÃ©ration. 

See 

64 

GLYCOCOLL 

see 

GLYCOL, 

GLYCINE 

METHANESULFONYL 

see 1,2-PROPANEDIOL, DIMETHANESULFONATE 

GLYCYRRHIZA GLABRA 

3601 3692 

GORDEEV SOLUTION 

1685 ~ 

Buleakova T. P. LECHENIE RAKAKOZHI ZHIDKOST'IU 

GORDEEVA. [SKIN CANCERTREATEDWITH THE GORDEEV 

SOLUTION.) Vopr. onkol., 1955, No. 1, 110-113. 

Gordeev solution (ZhG-1 and ZhG-2) was applied 

in skin cancer (mostly basal cell carcinoma) 

of 176 patients. ZhG-1 is administered with 

a 'drop intratissue injection' and has only 

slight effects; ZhG-2 is administered with a 

special grooved needle with which the tumor 

is punctured. The solution caused necrosis 

around the tumor. The inflammation following 

necrosis was treated with a lotion of 0.1 

crystallized iodine. 0.2 iodine potassium. 

1.0 chloramine, 10.0 English salt and 1000.0 

units jf water. Remissions were observed in 

1.7% of the cases. This treatment is cosmetically 

preferable to surgical treatment. 

1686 

Manchenko, N. S. PRIMENENIE ZHIDKOSTI GORDEEVA 

V USLOVIÃ•AKH ONKOLOGICHESKOGO KABINETA RAÃ•ONNOÃ• 

POI.IKI.INIKI . [THE USE OF GORDEEV LIQUOR IN 

ONCOLOGICAL OUT-PATIENTS DISTRICT DEPARTMENTS.] 

Vopr. onkol., 1956, 2: No. 1, 105-107. English 

summary. 

1687 

Â«Romaniuk, N. M. VPLIV RIDINI GORDEEVA NA 

AKTiyiUST' KATEPSINU I DEGIDROGENAZ TKANIN 

ZLOIAKISNIKH POVOTVORIV. [THE EFFECT OF THE 

GORDEEV SOLUTION ON THE ACTIVITY OF CATHEPSIN 

AND DEHYDROGENASE OF TUMORS.] Ukrain. biokhim. 

zh., 1954, 26: No. 1, 31-37. Abstracted in: 

Chem. AbstrTT 1955, 49: 1191Ã•. "The Gordeev 

solution inhibits the activity of cathepsin 

and dehydrogenase in intestinal and breast 

cancer as well as in transplanted Ehrlich 

carc-inoma in mice." - Chem. Abstr. 

GRAIN EXTRACTS 

1688 

Heaton, T. B. and Robinson, G. M. BIOLOGICAL 

PROPERTIES [GROWTH, TUMOR INHIBITION] OF A 

SUBSTANCE ISOLATED FROM WHEAT MIDDLINGS AND 

OF HYDROXYMETHYLFURFURALDEHYDE. Nature, Lond., 

1948, 162: 570. 8 refs. 

1689 

Men'shikov, G. P., Petrova, M. t. and Pukhal'skaia, 

E. Ã‡H. PROTIVOOPUKHOLEVAÃ•A AKTIVNOST' VODNYKH 

VYTÃŽAZHÃˆKIZ VYSSHYKH RASTENII. [ANTI-TUMOR 

ACTIVITY OF AQUEOUS EXTRACTS FROM HIGHER PLANTS.] 

Vopr. onkol., 1955, 1: No. 2, 44-49. 3 refs. 

Aqueous extracts of 

and ungernlfa which 

clover, hay, timothy grass 

are ordinarily without antitumor 

effects in experimental animals, could be 

made anti-tumor effective by treating the ex 

tracts with ethyl alcohol. Such extracts used 

on 7 strains of transplanted 

60-78% the growth of sarcoma 

tumors inhibited 

45; 30-45% the 

growth in 4 strains of Geren Crocker, LIO-1 and 

SSK sarcomas; and no inhibition in 2 strains 

of Ehrlich and Ml. 

1690 Sugiura, K. EFFECT ON INTRAVENOUSINJECTION OF 

YEAST ANDBARLEYEXTRACTSANDL. CASEI FACTOR 

UPON SPONTANEOUSMAMMARYADENOCARCINOMA 

MICE. In: APPROACHESTO TUMORCHEMOTHERAPY. 

Wash., Sm. Ass. Advance. Sc., 1947, p. 208- 

213. 13 refs. 

GT 41 

see BUTANE, 

GUANIDINE, SULFO- 

SM 

an 

H 11 

see URINE EXTRACT. H 11 

H365 

see PROPIOPHENONE, 

1,4-DIMETHANESULFONYLOXY 

p-HYDROXY-



96 

HEMATOPORPHYRIN 

1691 

Amsallera, Wâ€žand Amsallem, H. LES SUBSTANCES 

FLUORESCENTES ET LEURS DÃ‰RIVÃ‰SEN CARCINOLOGIE 

EXPÃ‰RIMENTALE. I. [FLUORESCENT SUBSTANCES 

AND THEIR DERIVATIVES IN EXPERIMENTAL CARCI- 

NOLOGT. 

229-249. 

I.] Bull, algÃ©r. Carcin., 1953, 6: 

Abstracted in: Excerpta med., Sect. 

16, 1954, No. 3500. "The average weight of 

the tumours was markedly reduced by this treat 

ment and the survival was slightly increased." 

1692 

Schmidt, F. BEEINFLUSSUNG DER LYMPHATISCHEN 

LEUKÃ„MIE DURCH PHOTODYN. [PHOTODYN TREAT 

MENT OF LYMPHATIC LEUKEMIA.] Deut. Gesundhwes., 

1947, 2: 454. 

HEPARIN 

1693 Albert-Weil, J. and Nehorais, J. A PROPOS DE 

DEUX CAS DE NÃ‰OPLASIESNON JUSTICIABLES DES 

THÃ‰RAPEUTIQUESCLASSIQUES, TRAITÃ‰ESPAR DES 

INJECTIONS INTRAVEINEUSES D'HÃ‰PARINE ET DES 

INJECTIONS INTRAMUSCULAIRES D'UN EXTRAIT DE 

SANGSUE. [TWO CASES OF NEOPLASM, NOT RE 

SPONDING TO CLASSICAL THERAPEUTICAL METHODS, 

TREATED BY INTRAVENOUS INJECTION OF HEPARIN 

AND INTRAMUSCULAR INJECTION OF AN EXTRACT OF 

LEECHES.] Rev. path, gÃ©n., Par., 1954, 54: 

1014-1020. Discussion: p. 1019-1020. 


16, 1955, 3: No. 1855. The combined treat 

ment causea regression of the tumoral masses 

in two patients. One patient died of uremia, 

the second one was still under treatment. 

1694 

Heilbrunn, L. V. and Wilson, W. L. THE EFFECT 

OF HEPARIN ON CELL DIVISION. Proc. Soc. Exp. 

Biol., N. Y., 1949, 70: 179-182. 13 refs. 

See 

183 

HEPBISUL 

see HEPTYL 

HEPTYL 

ALDEHYDE 

ALDEHYDE 

1695 Gruber, C. M., De Beradinis, C. T., Shields, 

H. L. and Copeland, J. E. A PHARMACOLOGIC 

AND TOXICOLOGIC STUDY OF HEPTYL ALDEHYDE 

SODIUM BISULFITE (HEPBISUL). J. Pharm. 

Exp. Ther., 1950, 98: 274-285. 10 refs. 


3: No. 5920. 

1696 Herbut, P. A., Kraemer, W. H. and Jacksen, J. 

THE EFFECT OF HEPBISUL (HEPTYL ALDEHYDE-SODIUM 

BISULFITE ADDITION COMPOUND) AND THYROXIN ON 

WALKER RAT CARCINOMA 256. Am. J. Path., 1951, 

27: 59-83. 5 pi. 17 refs. 

HETEROAUXm 

see ACETIC ACID, 3-INDOLE, 

HETEROCYCLIC 

COMPOUNDS 

1697 

Rhines, R. TESTS OF SOME HETEROCYCLIC COM 

POUNDS AGAINST MOUSE LEUKEMIA. Cancer 

1955, Suppl. No. 2, 145-146. Negative 

Res., 

data. 

HEXANOL 

See 

81 

fflSTAMINE 

1698 

Rulla, L. ISTAMINA E TUMORI; RICERCHE SPERI 

MENTALI. [HISTAMINE AND TUMORS: EXPERIMENTAL 

STUDIES.] 

rl9 refs. 

Neoplasie. Tor., 1950 4: 135-144. 

Histamine in doses of O.r mg ad 

ministered on alternate days to 25 albino 

rats caused a slight decrease in growth of 

Ehrlich adenocarcinoma, prolonged the survival 

time and promoted decrease in body weight. 

fflSTONES 

1699 

*Zbarskii, I. B. and Perevoshchikova, K. A. 

VLIIANIE GISTONOV NA ROST EXPERIMENTAL 'NOI 

SARKOMY MYSHEI. [EFFECT OF HISTONES ON 

GROWTH OF EXPERIMENTAL SARCOMA IN MICE.] 

Biull. 

61-64. 

eksp. biol. med., 1954, 38: No. 10, 

HOLOTHURIN 

1700 

Â«Nigrelli, R. and Zahl, P. A. SOME BIOLOGICAL 

CHARACTERISTICS OF HOLOTHURIN. Proc. Soc. 

Exp. Biol., N. Y., 1952, 81.: 379-380. 

HORMONES 

1701 Bernard, J. and Bessis, M. LEUCÃ‰MIES ET GLANDES 

ENDOCRINES. [LEUKEMIA AND ENDOCRINE GLANDS.] 

Sang, Par., 1952, 23: 205-233. Bibliography: 

p. 230-233. Experimental research: p. 205-209. 

Experimental and clinical research with a 

review. 

1702 

Casabona, U. LE CONOSCENZE ATTUALI SULLA REAZIONE 

DEL TESSUTO NEOPLÃ•STICO ALL'AZIONE DEI PREPARATI 

ORMONALI. [CURRENT KNOWLEDGE ON THE REACTION 

OF NEOPLASTIC TISSUE TO HORMONAL PREPARATIONS.] 

Minerva gin., Tor., 1950, Â£: 9-13. Approx. 

50 refs. A critical review devoted to clinical 

and experimental investigations, which prove 

that hormones have a direct action on tumors, 

producing regression of the neoplastic cells. 

1703 

Lipschutz, A. BASES EXPERIMENTALES DE LA HORHONO- 

TERAPIA DEL CÃ•NCER. I. [EXPERIMENTAL BASES 

OF HORMONE THERAPY IN CANCER. I.] 

invest., B. Air., 1949, 5: 317-325. 

Cienc. & 

44 refs. 

1704 

Millar, M. J. and Noble, R. L. EFFECTS OF 

EXOGENOUS HORMONES ON GROWTH CHARACTERISTICS 

AND MORPHOLOGY OF TRANSPLANTED MAMMARY FIBRO 

ADENOMA OF THE RAT. Brit. 

8: 495-507. 16 refs. 

J. Cancer, 1954, 

See 

3230 

HORMONES. 

ADRENAL 

see also HORMONES. CORTICOTROPIN (ACTH); 

STEROIDS. ALDOSTERONE, CORTICOSTERONE, 

CORTICOSTERONE, 11-DEHYDRO-, CORTICO 

STERONE, 11-DESOXY-, CORTICOSTERONE, 17- 

HYDROXY-, AND CORTISONE. 

1705 

Â«Burnaz, L. S. VLlfÃ€NIE IN'EKTSII ADRENALINA I 

ADRENALINIONOFOREZA NA ROSÃ• EXPERIMENTAL' NYKH 

ZLOKACHESTVENNYKH OPUKHOLEI. [THE EFFECT OF 

ADRENALIN INJECTIONS AND ADRENALIN-IONTOPHO 

RESIS UPON THE GROWTH OF EXPERIMENTAL, MALIG 

NANT TUMORS.] 153 p. Disser. Simferopol., 

1947. Abstracted in: Sov. med. reÃ. obozr., 

No. 1, 1949, p. 10. Adrenaline and ionto 

phoresis of adrenaline caused a regression of 

tumor growth in 16% of 72 animals with tumors 

chiefly of the connective tissues.



97 

HORMONES. 

ADRENAL (Continued) 

1706 Diller, I. C., Beck, L. V. and Blauch, B. EFFECT 

OF ADRENAL CORTICAL EXTRACT ON THE GROWTH 

CERTAIN MOUSE TUMORS. Cancer Res., 1948, 

OF 

8: 

581-589. 13 refs. 2 pi. Intraperitoneal 

injections of adrenal cortical extract in 

mice Â»ittiimplanted mouse sarcoma 37 greatly 

increased the regression of tumors in female 

but not in male mice. Repeated injections 

had no effect on the growth of definitely 

established methylcholanthrene-induced sarcomas. 

1707 Eschbach, W. DER EINFLUSS VON ARTERENOL UND 

ADRENALIN AUF DAS WACHSTUM DES JENSEN- 

SARKOMS BEI RATTEN. [THE INFLUENCE OF 

ARTERENOL AND ADRENALIN ON THE GROWTH 

JENSEN'S SARCOMA IN RATS]. Arch. Geschwulstforsch., 

OF 

1954, 7:361-364. 33 refs. 

Implants of Jensen's sarcoma in rats are 

not affected by the administration of ad 

renaline and noradrenaline. 

1708 

LettrÃ©, H.. LettrÃ©, R. and Riemenschneider, W. 

ZUR MITOSEHEMMENDEN WIRKUNG DES ADRENALINS. 

[MITOSIS INHIBITING 


ACTION 

1951, 

OF ADRENALINE.] 

38: 282-283. 

9 refs. Crystallized 

of 100-200 mg per cc 

adrenochrome 

caused 15-45% 

in doses 

of mitotic 

inhibition in fibroblasts. Noradrenaline in 

doses up to 500 mg per cc showed no effect. 

1709 

LettrÃ©, H., Marquardt, P. and Carl, E. WEITERE 

UNTERSUCHUNGEN ÃœBER DIE ZELLTEILUNGSHEMMENDE 

WIRKUNG VON ADRENALIN UND DERIVATEN. [NEW 

INVESTIGATIONS ON THE ANTIMITOTIC ACTION OF 

ADRENALINE AND ITS DERIVATIVES.] Hoppe Seyler 

Zschr., 1952, 291: 99-103. Abstracted in: 

Excerpta med.,"Sect. 16, 1954, 2} No. 575. 

1710 

Lewis, M. R. and Aptekman, P. M. INHIBITORY 

ACTION OF ADRENALIN 

Science, 1951, 113: 

ON GROWTH 

557-558. 

OF RAT SARCOMA. 

3 refs. The 

tumor inhibiting action of adrenalin seemed 

to be caused by damage to the vascularization 

of the tumor tissue followed by its absorp 

tion. 

Reid, E. GROWTH HORMONE AND ADRENOCORTICAL 

HORMONES IN RELATION TO EXPERIMENTAL TUMORS: 

A REVIEW. Cancer Res., 1954, 14: 249-266. 

181 refs. 

1712 

Roberts, S. and White, A. THE INFLUENCE OF THE 

ADRENAL CORTEX ON AEROBIC GLYCOLYSIS BY NOR 

MAL AND MALIGNANT RAT LYMPHOID 

crinology, 1953, 52: 372-377. 

TISSUE. 

14 refs. 

Endo 


8: No. 314. 

See 

3181 3572 

HORMONES. CORTICOTROPIN (ACTH) 

1713 

Baserga, R. and Shubik, P. THE ACTION OF CORTI 

SONE ON TRANSPLANTED 

MICE. Cancer Res., 

AND INDUCED TUMORS IN 

1954, 14: 12-16. 2 pi. 


16, 1954, 2: No. 3501 

1714 

Driessens, J. and Clay, A. REGRESSION DU SARCOME 

DE CROCKER DE LA SOURIS SOUS L'ACTION DE L'ACTH. 

[REGRESSION OF CROCKER'S SARCOMA IN THE MOUSE 

AFTER ADMINISTRATION OF ACTH.] C. rend. Soc. 

biol., 1952, 146: 1114-1115. Abstracted in: 

Chem. Abstr.,~TS53, 47: No. 6032h; Index 

analyt. cancer., Par., 1953, 24: No. 713. 

1715 Lannek, N. THE EFFECT OF ADRENOCORTICOTROPIC 

HORMONE (ACTH), CORTISONE, AND HYDROCORTISONE 

ON THE GROWTH OF EXPERIMENTAL LYMPHOID TUMORS 

IN CHICKS. Brit. J. Cancer, 1952, 6: 369- 

376. 11 refs. 

1716 

Rasquin, P. and Hafter, E. RESPONSE OF A SPON 

TANEOUS FISH LYMPHOSARCOMA TO MAMMALIAN ACTH. 

Zoologica, N. Y., 1951, 36: 163-169. 1 pi. 

23 refs. Abstracted in:~Ã¼hem. Abstr., 1953, 

47: 12659b. 

1717 Willig, H. TIEREXPERIMENTELLE UNTERSUCHUNGEN 

ÃœBERDEN EINFLUSS VON ACTH AUF DAS GESCHWULST- 

WACHSTUMDES JENSEN-SARKOMS BEI RATTEN. [ANI 

MAL EXPERIMENTS ON THE EFFECTS OF ACTH ON 

GROWTH OF JENSEN SARCOMA IN RATS.] Aerztl. 

Forsch., 1954, 8: 125-126. ACTH had no in 

fluence on the growth of the sarcoma. 

1718 

Yoffey, J. M. and Baxter, J. S. SOME EFFECTS 

OF PITUITARY ADRENOTROPIC HORMONE (PATH), 

EXTRACT OF SUPRARENAL CORTEX, AND COLCHICINE 

ON THE HAEMOPOIETIC SYSTEM. J. Anat., Lond., 

1946, 80: 132-138. 3 pi. 

See 

112 

2226 

HORMONES. 

1339 

3157 

1455a 

3170 

DI2THYLSTILBESTROL 

1711 

3285 

1893 

3601 

1719 

Horning, E. S. THE EFFECT OF CASTRATION AND 

STILBOESTROL ON PROSTATIC 

Brit. J. Cancer, 1949, 3j 

TUMOURS IN MICE. 

211-230. 35 refs. 

1720 

Ludford, R. J. and Dmochowski, L. EFFECT OF 

STILBOESTROL ON MOUSE TUMOURS. Lancet, Lond., 


Excerpta med., Sect. 5, 1948, 1^:No. 643. 

The action of diethyl-stilboestrol on different 

types of mammary carcinomas, a carcinosarcoma, 

a squamous-celled carcinoma, a lung carcinoma 

and two sarcomas was investigated. No specific 

inhibition of growth was shown and such inhibi 

tion as took place was the result of a non 

specific toxic action. Stilboestrol did not 

induce the same type of mitotic action as 

colchicine. 

1721 Schmahl, D. ZYTOTOXISCHE WIRKUNGEN DES STIL- 

BOSTROLS AUF DIE ZELLEN DES WALKER-CARCINOMS 

DER RATTE. [THE CYTOTOXIC EFFECT OF STIL- 

BESTROL ON THE CELLS OF THE WALKER CARCINOMA 

IN RATS.] Arzneimitt. Forsch., 1954, 4: 481- 

484. 20 refs. 

1722 

Shapiro, D. M. COMBINATION CHEMOTHERAPY WITH 

8-AZAGUANINE AND SEX HORMONES ON A MOUSE 

MAMMARY CARCINOMA. Cancer Res., 1952, 12: 

713-715. "Diethylstilbestrol inhibits th~e 

See 

3574 

growth of 755 mammary adenocarcinoma in 

C 57 BL mice. The combination of 8-azaguanine 

and stilbestrol has a striking carcinostatic 

effect upon the 755 tumor. Weight 

loss induced by stilbestrol...is reduced to 

insignificant levels by the addition of 

testosterone without affecting carcinostatic 

activity." 

HORMONES. 

ESTROGENS 

see also HORMONES. DIETHYLSTILBESTROL



HORMONES. 

ESTROGENS (Continued) 

1723 

Albano, A. AZIONE DELLA FOLLICOLINA SULLA 

GLICOLISI AEROBIA E ANAEROBIA DI TUMORI 

SPERIMENTALI. [THE EFFECT OF OESTROGENS 

ON AEROBIC AND ANAEROBIC GLYCOLYSIS IN 

EXPERIMENTAL TUMORS.] Tumori, Milano, 

1954, 40: 184-188. 5 reÃs. Abstracted 

in: Excerpta ned.. Sect. 5, 1955, 8: 

No. 773 

1724 

Biggers, J. D. and Claringbold, P. J. MITOTIC 

ACTIVITY IN THE VAGINAL EPITHELIUM OF THE 

MOUSE 

TION. 

FOLLOWING LOCAL OESTROGENIC 

J. Anat., Lond., 1955, 89: 

STIMULA 

124-131. 

pi. 26 refs. 

1725 

Dirscherl, W. and Breuer, H. ZUR FRAGE EINER 

DIREKTEN STOFFWECHSELBEEINFLUSSUNG MENSCHLICHER 

KREBSGEWEBE DURCH SEXUALHORMONE. [THE EFFECT 

OF SEX HORMONES ON HUMAN TUMOR TISSUE META 

BOLISM.] Zschr. Krebsforsch., 1953, 59: 253- 

260. 24 refs. A study of the effect of 

testosterone propionate, * -estradiol and 

estrone on human tumor tissue respiration and 

aerobic and anaerobic glycolysis. The meta 

bolism of intestinal, gastric and bladder 

carcinomas were not affected by the hormones; 

mammary and prostatic carcinoma metabolism 

was altered to some extent. 

1726 

Druckrey, H., Danneberg, P. and SchmÃ¤hl, D. 

MITOSEGIFTWIRKUNG VON OESTROGENEN. [ANTI- 

MITOTIC ACTIVITY OF ESTROGENS]. 

senschaften, 1952, 39: 381-382. 

Naturwis 

15 refs. 

Abstracted in: Chen. Abstr., 1953, 47: No. 

8248c. Experiments on sea-urchin egg cells 

showed that the compounds have a direct antimitotic 

effect. This activity is emphasized 

in relation to cancer chemotherapy. 

1727 

Horning, E. S. HORMONES IN RELATION TO CANCER. 

Tr. M. Soc. London, 1954, 70: 42-49. 7 refs. 

1728 

Rapoport, A. L. MORFOLOGICHESKIE POKAZATEH 

EFFEKTIVNOSTI LECHEBNOGO VOZDEÃ•STVIÃŽÃ€NA 

OPUKHOLEVYÃ• PROTSESS. [MORPHOLOGICAL CRI 

TERIA OF SUCCESSFUL TREATMENT OF TUMOURS.] 

Usp. sovr. Biol., 1952, 33: 64-80. 1 pi. 

14 refs. Abstracted in:~E~xcerpta med., 

Sect. 5, 1952, 5: No. 3799. Findings on the 

application of synestrol to Crocker mouse 

sarcomas and to tissue cultures of human 

prostate carcinomas. 

1729 

Repetto, A. ESTROGENI E SARCOMA GALL IERA; I. 

RAFFRONTO FRA L'AZIONE DELLA FOLLICOLINA 

NATURALE E DEGLI STILBENICI SULL'ATTECCHIMENTO 

E SULLO SVILUPPO DEL SARCOMA GALLIERA. 

FECTS OF ESTROGENS ON GALLIERA SARCOMA; 

[EF 

RE 

LATION BETWEEN EFFECTS OF NATURAL AND STIL- 

BENIC ESTROGENS ON GROWTH AND DEVELOPMENT.] 

Tumori, Milano, 1947, -Â¿l : 167-172. 40 refs. 

The estrogens produced~necrosis and a re 

duction in growth of the tumor occurred. 

1730 

Schlag, H. and Boll, I. ÃœBER DIE EINWIRKUNG 

VON OESTRADIOL AUF KNOCHENMARKZELLEN IN 

VITRO. [EFFECT OF ESTRADIOL ON BONE MARROW 

CELLS IN VITRO.] Aerztl. Wschr., 1951, 6: 

1116-1119. 22 refs. 

See 

299 1926 3154 

HORMONES. 

INSULIN 

1731 

Bayer, R. DIE WIRKUNG DER ERZWUNGENEN HYPO- 

GLYKAMIE AUF DAS GENITALKARZINOM DER FRAU. 

[THE EFFECT OF INDUCED HYPOGLYCEMIA ON 

GENITAL CANCER IN WOMEN.] Krebsarzt, Wien, 



Tumor necrosis and reduction oJ mÃ©tastases 

in 14 cases of genital cancer was obtained 

by the following combined treatment causing 

hypoglycemia: ligature of both hypogastric 

arteries, diabetic diet(low carbohydrate) 

and the administration of insulin for 4-68 

units per day. This treatment not to ex 

ceed 3 weeks 

non-operable 

duration 

cases of 

is recommended for 

cancer of the cervix 

uteri. 

1731a 

Gitman, L., Levine, E. A., Appelman, D. H., and 

Jacob!, M. EFFECT OF INSULIN AND GLUCOSE IN 

CHRONIC LYMPHATIC LEUKEMIA! N. Y. 

M., 1951, 51:2257-2259. 15 refs. 

State J. 

1732 

KolaÃ¯, V. INSULIN A KOZNI RAKOVINA. [INSULIN 

AND CANCER OF THE SKIN.] Lek. listy, 1948, 

3: 438-440. 3 refs. Insulin in doses of 

20 units to l g was applied as an ointment to 

skin cancer of basal cell type. Sume im 

provement was noted. 

1733 

Woods, M., Wight, K., Hunter, J. and Burk, D. 

EFFECTS OF INSULIN ON MELANOMA AND BRAIN 

METABOLISM. Biochim. biophys. acta, Amst., 


Chem. ATstr., 1954, 48: 1556b. 

HORMONES. PINEAL GLAND 

1734 Bergmann, W. and Engel, P. UEBER DEN EINFLUSS 

VON ZIRBELEXTRAKTEN AUF TUMOREN BEI WEISSEN 

MAUSEN UND BEI MENSCHEN. [THE EFFECT OF EX 

TRACT FROM THE PINEAL GLAND ON TUMORS IN 

WHITE MICE AND IN HUMANS.] Wien, klin. Wschr,, 

1950, 62: 79-82. Approx. 20 refs. Abstracted 

in: i neli-x analyt. cancer., Par., 1951, 22: 

No. 385. 

HORMONES. 

PITUITARY 

see also HORMONES. CORTICOTROPIN (ACTH) 

1735 Paolo, R. AZIONE DELL'ORMONE PREIPOFISARIO 

TIREOTROPO SULL'ACCRESCIMENTO DELL'ADENOCAR 

CI NOMA DI EHRLICH. [EFFECT OF THE ANTERIOR 

PITUITARY THYROTROPIC HORMONE ON THE GROWTH 

OF THE EHRLICH ADENOCARCINOMA.] Neoplasie, 

Tor., 1950, 4: 303-310. 11 refs. 

1736 

Schulman, M. P. and Greenberg, D. M. EFFECT 

OF PURIFIED GROWTH HORMONE ON TUMOR GROWTH. 


676-677. 13 refs. The growth of sarcoma 

37 and mammary adenocarclnoma in strain A 

mice was not influenced. 

1737 Slattery, P. A., Lyons, W. R. and Shimkin, M. B. 

LACK OF EFFECT OF LACTOGENIC HORMONE ON MAM 

MARY ADENOCARCINOMA 

Biol., N. Y., 1950, 

IN MICE. Proc. Soc. Exp. 

74: 539-540. 7 refs. 



No. 36270. 

1738 

Smith. M. C., Daane, T. A., Li, C. H., Shimkin, 

M. B., Lyons, W. R., Sparks, L. L. and Furnas, 

D. W. FURTHER STUDIES ON THE EFFECTS OF PITUI 

TARY GROWTH HORMONE (STH) ON C3H MICE BEARING 

A TRANSPLANTED MAMMARY ADENOCARCINOMA. Cancer 

Res., 1954, 14: 386-390. 5 refs. Abstracted 

in: Excerpta~med., Sect. 5, 1955, 8: No. 469. 

HORMONES. 

See 

752 

PLANT



99 

HORMONES. 

STILBESTROL 

see HORMONES. 

HORMONES. 

THYROID 

DIETHYLSTILBESTROL 

1739 

Barker, S. B. and Schwartz, H. S. EFFECT OF 

THYROID FUNCTION ON TISSUE METABOLISM OF 

TUMOR-BEARING RATS. Cancer Res., 1953, 13: 

817-819. 8 refs. No marked changes in 

growth rate or cytological appearance of the 

tumors in the different states of thyroid 

function was observed. 

See 

1696 1711 2843 

HOXSETS 

TREATMENT 

1740 COMMENT ONCOURTOPINIONTHATINTERNAL CANCER 

CAN BE CURED WITH MEDICINE. J. Am. M. Ass., 

1951, 145: 252-253. 

1741 

MR. HOXSEY HAS 

150: 54-55. 

HYALURONIDASE 

A SETBACK. J. Am. M. Ass., 1952, 

1742 

Fuzita, K. and Iwase, S. INFLUENCE OF MUCIN AND 

HYALURONIDASE UPON THE GROWTH OF CHICKEN SAR 

COMA. Nagoya J. M. Se., 1952, 15: 261-269. 

7 refs. 

1743 Pearce, J. II. and LaSorte, A. F. EFFECTS OF 

AN ANTIHYALURONIDASE 

LURONIDASE ON GROWTH 

SUBSTANCE AND OF HYA 

OF VIRUS-INDUCED FIBRO 

MAS. Proc. Soc. Exp. 

86: 573-577. 5 refs. 

Biol., N. Y., 1954, 



91 

HYDRAZINE 

DERIVATIVES 

1744 

Freedlander, B. L. and FÃ¼rst, A. EFFECT OF 

SUBSTITUTED HYDRAZINES AND RELATED 

ON MYELOID MOUSE LEUKEMIA C-1498. 

COMPOUNDS 

Proc. Soc. 

Exp. Biol., N. Y., 1952, 81: 638-640. 

1745 

Simon, K. UNTERSUCHUNG VON DERIVATEN DES HY 

DRAZINS AUF IHRE CYTOSTATISCHE WIRKUNG AM 

ASCITESTUMOR DER MAUS. [THE CYTOSTATIC 

ACTION OF HYDRAZINE DERIVATIVES ON ASCITES 

TUMOR IN MICE.] Zschr. Naturforsch., 1952, 

TbJ 531-536. 38 refs. 

HYDRAZINE, 

PHENYL_ 

1746 

Cattaneo, A. and de Fillippi, P. LA SIDEREMIA 

NELLA POLICITEMIA VERA; SUO COMPORTAMENTO DU 

RANTE IL TRATTAMENTO CON FENILIDRAZINA. [BE 

HAVIOR OF IRON IN BLOOD DURING PHENYLHYDRAZINE 

THERAPY OF POLYCYTHEMIA VERA.] 

Tor., 1947, 38: pt. 2, 210-211. 

Minerva med., 

1747 

Denis, A. LE TRAITEMENT DES POLYGLOBULIES. 

Â¡THE TREATMENT OF POLYCYTHEMIA.] Sup. 

Paris, 1948. (ThÃ¨se - Paris) 27 refs. 

1748 

Gessler, C. BEHANDELING VAN DE POLYCYTHAEMIA 

VERA. 

tschr. 

[THERAPY OF POLYCYTHEMIA VERA.] 

geneesk., 1946, 2\ 316-321. 

Belg. 

1749 

GyÃrgy, L. A POLYCYTHAEMIA KEZELÃ‰SE PHENYL- 

HYDRAZINNAL. [TREATMENT OF POLYCYTHEMIA 

WITH PHENYLHYDRAZINE.] ' Orv. lapja, 1947 

3: 41-44. 15 refs. 

1750 

Jacobson, L. 0. and Smith, T. R. THE EVALUA 

TION OF THE PRESENT FORMS OF TREATMENT OF 

POLYCYTHEMIA RUBRA VERA. Am. Practitioner, 

1949, 3: 267-270. 22 refs. 

1751 Keesal, S. and Margolis, N. ACUTE HEMOGLOBIN- 

URIC NEPHROSIS (ETIOLOGY-PHENYLHYDRAZINE 

TREATMENTOF POLYCYTHEMIAVERA). Urol. Cut. 

Rev., 1951, 55: 401-404. 14 refs. 

1752 

O'Connell, W. J. and Jahsman, W. E. POLYCY 

THEMIA VERA; VARIABILITY OF PRESENTING SYMP 

TOMS; ECONOMICAL AND SYMPTOMATICALLY SATIS 

FACTORY TREATMENT WITH PHENYLHYDRAZINE. 

J. Michigan M. Soc., 1946, 45:: 633-642. 

74 refs. Except in patientsTntolerant to 

phenylhydrazine, this preparation proved 

equally as satisfactory as treatment by 

venesection,spray irradiation or radioactive 

drugs. 

1753 

Plauchu, M., Morel. P., Lehmann, M. and 

Bethenod, M. ANEMIE AIGUÃ‹ AU COURS DU 

TRAITEMENT D'UNE POLYGLOBULIE PAR LA PHENYL 

HYDRAZINE. (A PROPOS D'UNE OBSERVATION). 

[ACUTE ANAEMIA DURING TREATMENT OF POLYCY 

THAEMIA WITH PHENYLHYDRAZINE; 

Lyon mÃ©d., 1951, 185: 33-40. 

CASE REPORT.] 

14 refs. 

Abstracted in: ExceTpta med., Sect. 2, 1952, 

5: No. 5503. 

HYDROCARBONS, 

POLYCYCLIC 

1754 

Green, H. N. AN IMMUNOLOGICAL CONCEPT OF CANCER; 

A PRELIMINARY REPORT. 

1374-1380. 17 refs. 

Brit. M. J., 1954, 2: 

Non-carcinogenic polycyclic 

hydrocarbons, which were isolated from 

coal-tar, inhibited growth of some transplanted 

tumors and delayed outgrowth of some spontaneous 

mouse tumors. Evidence indicated that these 

compounds 

that they 

alter certain protein complexes so 

behave as iso-antigens and excite 

production of homologous antibody. 

See 

3230 

HYDROQUINONE 

1755 

Bala, J., Vandor, F. and Reinman, P. HYDRO- 

CHINON HATÃ„SA AZ ATOLTHATÃ“ EGÃ‰RRÃ‚KNDVEKEDÃ‰SÃ‰RE. 

[EFFECT OF HYDROQUINONE ON THE GROWTH OF TRANS- 

PLANTABLE MICE CANCER.] KÃsÃ©rletesorvostud., 

1951, 3: 191-4. Hydroquinone did not inhibit 

experimental tumor growth. 

1756 

Kelly, K. H., Bierman, H. R. and Shimkin, M. B. 

NEGATIVE EFFECTS OF ORAL MONOBENZYL ETHER OF 

HYDROQUINONE IN MALIGNANT MELANOMA IN HAN. 

Proc. Soc. Exp. Biol., H. Ã•., 1952, 79: 589- 

590. 5 refs. Monobenzl ether of hyHroquinone 

had no effect upon the growth of mela 

noma in 8 patients. Other than transient 

nausea and vomiting, when daily doses ex 

ceeded 10 g., the compound had no toxic ef 

fects. 

1757 

Parmentier, R. ACTION FUSORIALE DE L'HYDROQUI- 

NONE CHEZ LA LAPINE. [ACTION OF HYDROQUINONE 

ON 

C. 

MITOTIC FIGURES IN THE FEMALE RABBIT.] 

rend. Soc. biol., 1953, 147: 935-937. 

1758 

Parmentier, R. and Dustin, p., Jr. EARLY EF 

FECTS OF HYDROQUINONE ON MITOSIS. Nature, 

Lond., 1948, 161: 527. 

1759 

Rosin, A. and Doljanski, F. EFFECT OF HYDRO 

QUINONE ON MITOSIS. Nature, Lond., 1953 

172: 1151.



100 

HYDROQUINONE (Continued) 

See 

822 2978 

HYDROQUINONE, 

1760 

LefÃ¨vre, R. and Baranger, P. CHIMIOTHÃ‰RAPIE 

ANTICANCÃ‰REUSE.[CANCERCHEMOTHERAPY.] 

ÃŒMOTHERAI 

Concours med., 1955, 77: 2329-2336. 33 refs. 

HYDROXY COMPOUNDS, 

1761 Alexander. P.. Fox. M., Stacey. K. A. and Smith, 

L. F. THE REACTIVITY OF RADIOMIMETIC COM 

POUNDS. I. CROSS-LINKING OF PROTEINS. 

Bioohem. J., Lond., 1952, 52: 177-184. 33 refs. 

Abstracted in: Excerpta mea7, Sect. 16, 1954, 

2: No. 570 

962 

HYDROXYLAMINE 

1762 

Cudkowicz, G. EFFETTO DELL'IDROSSILAMINA E 

DELLA SODIO AZIDE SULL'ACCRESCIMENTO DI ALCUNI 

TUMORI TRAPIANTABILI. [THE EFFECT OF HYDROXYL 

AMINE AND SODIUM ACID ON THE GROWTH OF SOME 

TRANSPLANTED TUMORS.] Tumori, Milano, 1955, 

41: 181-185. 23 refs. Hydroxylamine and 

sodium azide acid in doses of 60 mg and 14 mg 

respectively, Â»ere injected parenterally into 

rats with Walker sarcoma and to mice with 

Ehrlich adenocarcinoma and sarcoma 180. Hy 

droxylamine did not affect the growth of 

Walker sarcoma or sarcoma 180; it reduced 

the growth of Ehrlich adenocarcinoma by 50%. 

Sodium acid reduced the growth of all three 

tumors by 37%-50%â€ž 

IMIDAZO-1, 

2,3-TRIAZINES 

1763 

Biesele, J. J. FURINE ANTAGONISM AND DIFFERENTIAL 

TOXICITY OF SOME IMIDAZO-1,2,3-TRIAZINES IN 

MOUSE-TUMOR TISSUE CULTURES. Cancer, Phila., 

1952, 5: 787-791. 8 refs. 

INDIGO, MERCURIZED 

1764 

Gore, C. E. MERCURIZED INDIGO IN THE TREAT 

MENT OF HUMAN CANCER. J. Am. Osteopath. 

Ass., 1954, 53: 676-680. 9 refs. 

INDOLE, 

1 7fi5 

GERANYL- 

O-METHANESULPHONYL- 

TRfflYDROXY-N-METHYL- 

ChÃ¨vremont, M. and Chevremont-Comhaire,S. 

ACTION CELLULAIRE DU TRIHYDROXY-N-METHYLINDOLE , 

PARTICULIEREMENT SUR LE CHONDRIOME. [EFFECT 

OF TRIHYDROXY-N-METHYLINDOLE ON CELLS, ESPECIAL 

LY ON THE CHONDRIOMK.] C. rend. Soc. biol., 

1953, 147: 914-916. 10 refs. Trihydroxy-NmethyllnÃ¯ole 

was added in concentrations of 

IO"3 to IO"6 to media in which fibroblasts or 

myoblasts were cultivated in vitro at 38Â°C. 

The number of mitoses were reduced by preprophasic 

inhibition leading to inhibition of 

growth of the cultures. Nuclear changes were 

not seen and mitoses once started proceeded 

to division, but important changes of the 

chondriome were observed. 

INFECTIOUS DISEASES â€”¿ THERAPY 

Barling B. MULTIPLE MYELOMATOSIS WITH RE 

MISSION FOLLOWING ERYSIPELAS. Proc. R. 

Soc. M., Lond., 1949, 42: 175. A female, 

age 61, with multiple myelomatosis, whose 

condition had deteriorated until she was 

practically moribund developed severe 

erysipelas on the face. She again became 

ambulant and symptom-free but no change 

was seen in the X-ray picture. 

1767 

Bierman, H. R., Crile, D. M., Dod, K. S., 

Kelly, K. H., Petrakis, N. L., White, L. P. 

and Shimkin, M. REMISSIONS IN LEUKEMIA OF 

CHILDHOOD FOLLOWING ACUTE INFECTIOUS DISEASE: 

STAPHYLOCOCCUS AND STREPTOCOCCUS, VARICELLA 

AND FELINE PANLEUKOPENIA. Cancer, N. Y., 

1953, 6: 591-605. 14 refs. 

1768 

HopfengKrtner, F. REMISSION EINER LEUKÃ„MIE BEI 

TUBERKULOSE. [A REMISSION OF LEUKEMIA IN TU 

BERCULOSIS.] Mschr. Kinderh., 1953, 101: 


med., Sect. 16, 1955, 3: No. 186. 

1769 

Huth, E. F. DIE BEDEUTUNG DER SOG. SPONTAN 

HEILUNGEN UND REMISSIONEN FÃœR DIE THERAPIE 

UND PATHOGENESE DER LEUKOSEN UND MALIGNEN 

TUMOREN. [THE SIGNIFICANCE OF THE SO-CALLED 

SPONTANEOUS RECOVERY AND REMISSIONS IN THE 

THERAPY AND PATHOGENESIS OF LEUKOSIS AND 

MALIGNANT 

1952, 58: 

TUMORS.] 

524-575. 

Zschr. Krebsforsch., 

Bibliography: p. 572- 

575. Abstracted in: Biol. Abstr., Bait., 

1954, 28: No. 6063; Leukemia Abstr., 1953, 

1: No.~T9. In the literature about 1/3 of 

the remissions in leukemia, and an even 

greater proportion in sarcomas and carcino 

mas, were found to have occurred in the 

presence of purulent infections. "Tests 

with mice concerned both transplanted ascites 

carcinoma and spontaneous breast carcinoma, 

in the presence of one of the following or 

ganisms: Staphylococcus pyogenes aureus, 

OÃ¯dium albicans, yeast and PÃ©nicillium 

notatum. The latter species was especially 

effective in reducing the tumors in mice 

and was also the least toxic." -Leukemia 

Abstr. 

1770 Kastranek, T. UNERWARTETER RÃœCKGANG EINES IN 

OPERABLEN OVARIALKARZINOMS NACH POSTOPERATIVER 

SCHARLACHERKSANKUNG. [UNEXPECTED REGRESSION 

OF INOPERABLE OVARIAN CANCER AFTER POST-OPERA 

TIVE SCARLET FEVER.] Krebsarzt, Wien, 1947, 


med., Sect. 5, 1948, U No. 1009. 

177T Lachnit, V. CHRONISCHE MYELOISCHE LEUKXMIE, 

INTERKURRENT AN FLECKFIEBER ERKRANKT. [A 

CASE OF CHRONIC MYELOID LEUKEMIA WITH INTER 

CURRENT TYPHUS.] Wien. klin. Wschr., 1947, 

59- 73-75 5 refs. Abstracted in: Index 

aÃ¯alyt. cancer., Par., 1948, 19: No. 271. 

17TÃŒylor, A. W. EFFECTS OF GLANDULAR FEVER IN 

FECTION IN ACUTE LEUKAEMIA. Brit. M. J., 1953, 


Sed., Sect. 7, 1953, 7: No. 2065; Leukemia 

Abstr., 1953, 1: No. T97. 

See 

2700 

INOSITOL 

Herbst, W. P., Jr. and Bagley, C. E. OBSERVA 

TIONS IN THE USE OF INOSITOL IN ADVANCED 

MALIGNANCY OF THE GENITO-URINARY TRACT. 

Tr Am. Ass. Genitourin. Surgeons, (1947) 

1948, 39: 235-238.



101 

INOSITOL (Continued) 

1774 

Keresztesy, J. C., Laszlo, D. and Leuchtenberger, C. 

NEUTRALIZATION OF INHIBITION OF TUMOR GROWTH. 

Cancer Res., 1946, 6: 128-130. 9 refs. "Neu 

tralization by approximately equal amounts of 

inhibitor and antagonist was observed in the 

inositol: p-amino-benzoic acid, inositol: 

pyridoxine, and d-desthiobiotin: d-biotin ex 

periments. Thiamin, niacinamide, o- and m- 

aminobenzoic acid, and leucopterin were slightly 

active, if at all, in counteracting the inhibi 

tion caused by inositol...While both d-desthio 

biotin and an avidin concentrate were effective 

inhibitors of tumor growth, neutralization oc 

curred when these two materials were tested for 

antagonism. Impurities in the avidin concentrate 

may be responsible for this interference." 

1775 Zahl, P. A. and Hutner, S. H. NOTE: THE GROWTH- 

INHIBITION OF MOUSE SARCOMA 180. In: APPROACHES 

TO TUMOR CHEMOTHERAPY. Wash., Am.TJSS. Advance. 

Sc., 1947, p. 214-216. 8 refs. 

See 

252 3683 

IODINE 

1776 Schober, B. VLIIANIE IODA NA ROST ADENOKARTSI- 

NOMY U KRYS. [EFFECT OF IODINE ON THE GROWTH 

OF ADENOCARCINOMA IN RATS.] Chekh. fiziol., 

1952, 1.: 230-242. 22 refs. Walker mammary 

adenocarcinoma in 396 rats was treated with 

iodine, methylthiouracil and thyroidectomy. 

In young rats thiouracil slowed down the 

cancer growth, while iodine accelerated the 

growth in all animals. Thyroidectomy caused 

tumor regression. 

IRGAPYRIN 

See 

2953 

IRON COMPOUNDS â€”¿ EFFECT ON TUMOR GROWTH 

1777 

Banga, I., BalÃ³, J. and ReimÃ¡n. P. THE EFFECT 

OF SUBSTANCES INFLUENCING OXIDOREDUCTION ON 

THE GROWTH OF MOUSE CANCER. Acta physiol., 

1954, 5J 273-291. tab. 17 refs. 


No. 3499. "26...autoxidable metal complexes 

either stimulated or inhibited the growth of 

neoplasms. The most conspicuous tumor sti 

mulator was the Fe-ascorbic acid complex, 

the most effective inhibitor the Cd-ascorbic 

acid complex...A tumor growth inhibiting 

activity similar to that of Cd-complex is 

displayed by some Mn-complexes..." 

1778 

Magat, M. A. and Tarashchfnskaia, F. Z. DEISTVIE 

KOMPLEKSNOGO SOLDINENIIA ZHELEZA S VINNOKAMENNOI 

KISLOTOl NA ROST EXPERIMENTAL'NYKH OPUKHELEÃ•. 

[EFFECT OF IRON AND TAHTARIC ACID UPON THE 

GROWTH OF EXPERIMENTAL TUMORS.] Arkh. pat., 

Moskva, 1947, 6: 56-58. 

1779 

Morel, A. and Josserand, A. IMPORTANCE DES 

FACTEURS IPERICELLULAIRES' ENZYMATIQUES ET 

ALLERGIQUES POUR MODIFIER LE RYTHME Ã‰VOLUTIF 

DES TUMEURS Ã‰PITHELIALES. [IMPORTANCE OF 

ENZYMATIC AND ALLERGIC 'PERICELLULAR' FACTORS 

IN MODIFYING THE EVOLUTION OF EPITHELIAL 

TUMORS.] J. mÃ©d. Lyon, 1951, 32: 51-58. 


4: No. 2771. 

1780 

Rokujo, T. SCREENING TEST OF THE CHEMICAL COM 

POUNDS WHICH INHIBIT YOSHIDA SARCOMA (IV) 

WITH SPECIAL REFERENCE TO THE ACTION OF THE 

IRON COMPOUND AGAINST YOSHIDA SARCOMA. Gann, 

Tokyo, 1952, 43: 166-168. In Japanese. 

IntraperitoneaT injections of ferric chloride 

and ferrous chloride into Yoshida sarcoma 

bearing rats were found to exert a stronger 

inhibitory action than ferric citrate Â»r 

ferric oxalate. 

1781 

Rokujo, T. SCREENING TEST OF THE CHEMICAL COM 

POUNDS WHICH INHIBIT YOSHIDA SARCOMA V WITH 

SPECIAL REFERENCE TO THE ACTION OF IRON COM 

POUNDS AGAINST YOSHIDA SARCOMA. 

1953, 44; 382-383. In Japanese. 

Gann, Tokyo, 

IRON 

OXIDES 

1782 Schotten, W. 'ÃœBERDIE WIRKUNG INTRAVENÃ–SER 

INJEKTIONEN VON EISENOXYDULOXYD BEI KREBSER 

KRANKUNG. [EFFECTS OF INTRAVENOUS INJECTIONS 

OF FE3(OH)8 ON NEOPLASMS.] Zschr. ges. inn. 

Med., 1952, 7: 901-907. 7 refs. Review and 

report of 3 cases. It was shown that Fe3(OH)g 

in the blood can cause tumor regression and 

improve the general condition of dying 

patients. 

1783 

White, L. P., Bierman, H. R., Kelly, K. H. and 

Byron, R. L., Jr. THE IMMEDIATE HEMATOLOGIC 

EFFECTS OF INTRAVENOUS SACCHARATED IRON OXIDE, 


"Saccharated ferric oxide in colloidal sus 

pension was administered intravenously on 17 

occasions to 13 patients in doses of 100 to 

1,000 mg. A prompt arterial leukopenia, 

followed within 30 to 90 seconds by a similar 

fall in the venous blood, was observed in all 

patients 

iron." 

who received more than 200 mg of 

ISATOATE, 

1784 Enders, A. and Tecklgnborg, E. DIE CYTOSTATISCHE 

WIRKUNG VON ISOTOSAURE-MONO-EXO-ISOPROPYLESTER 

BEI REAKTIVEN LEUCOSEN. [THE CYTOSTATIC EF 

FECT OF MONO-EXO-ISOPROPYLISATOATE IN REACTIVE 

LEUKEMIA.] Arch, internat, pharm. dyn., Gand, 


Leukemia" Abstr., 1955, 3: No. 1136. 'The ef 

fect of mono-exo-isopropylisatoate (MEIP) on 

reactive leukemia, induced in rats and rabbits 

with Boehringer's anti-thrombotic agent and 

in dogs with Pyrifer, was investigated. MEIP 

repressed the increase in lymphocytes to a 

greater extent than that in granulocytes and, 

with its use, it was found possible to reduce 

or even inhibit the disease completely." 

- Leukemia Abstr. 

ISOALLOXAZINE, 

MONO-EXO-ISOPROPYL- 

6-CHLORO-9-(l'-D-SORBITYL)- 

1785 Shapiro, D. M. and Fugmann, R. A. COMBINATION 

CHEMOTHERAPY OF CANCER WITH 8-AZAGUANINE AND 

A RIBOFLAVIN ANALOG. Proc. Soc. Exp. Biol., 


Excerpta med.7~Sect. 2, 1954, 7: No. 1665. 

See 

3498 

ISOALLOXAZINE, 6, 7-DICHLORO-9, l'-D-SORBITYL- 

1786 

Holly, F. W., Peel, E. W., Mozingo, R. and 

Folkers, K. STUDIES ON CARCINOLYTIC COMPOUNDS. 

1. 6,7-DICHLORO-9-(I1-D-SORBITYL)-ISOALLOXA 

ZINE. J. Am. CheÂ«. Soc., 1950, 72; 5416-5418. 

16 refs. Abstracted in: Excerpt5~~med., Sect. 

2, 1951, 4: No. 5647.



103 

ISOALLOXAZINE, 

See 

3487 

ISONIAZro 

6, 7-DIMETHYL-9-HYDROXYETHYL- 

1787 

Simon, K. ZUM WIRKUNGSMECHANISMUS EINIGER 

MITOSEGIFTE. [MECHANISM OF ACTION OF SOME 

MITOTIC POISONS.] Krebsarzt, Wien, 1954, 

9: 164-166. 8 reÃs. 

1788 

Â»Vangelista, G. SULL'INNESTO NEOPLÃ•STICO ETERO 

GENEO: INFLUENZA DELL'IDRAZIDE DELL'ACIDO 

ISONICOTINICO SULL'ATTECCHIMENTO ED EVOLUZIONE 

DELL'ADENOCARCINOMA DI EHRLICH NEL RATTO 

ALBINO. [HETEROLOGOUS NEOPLASTIC GRAFTS: IN 

FLUENCE OF INK ON IMPLANTATION AND COURSE OF 

EHRLICH'S ADENOCARCINOMA IN ALBINO RATS.] 

Boll. Soc. med. chir., Modena, 1953, 53: 259- 

266. 

ISONICOTINIC ACID HYDRAZIDE 

see ISONIAZID 

JANUS GREEN 

1789 GUttes, E. and Schmahl. DIE WIRKUNGVON JANUS- 

GRÃœNAUF TUMORZELLEN. [THE EFFECT OF JANUS 

GREEN ON TUMORCELLS.] Arzneimitt. Forsch., 

1954, 4: 479-481. 5 refs. Janus green 

caused~an increased percentage of chromosome 

bridges in the ana-telophase of Yoshida sar 

coma in rats, as well as of Ehrlich carcinoma 

in mice. - Translation. 

KHELLIN 

1780 Apffel, C. A. DIE ZYTOSTATISCHE WIRKUNG VON 

CHINONEN UND IHREN DERIVATEN; ZUR HEMMUNG 

MENSCHLICHER TUMOREN DURCH KHELLIN. [THE 

CYTOSTATIC EFFECTS OF QUIÃ‘ONES AND OF THEIR 

DERIVATIVES; GROWTH INHIBITION OF HUMAN 

TUMORS WITH KHELLIN.] Deut. med. Wschr., 

1955, 80: 414-416. 

KIDNEY EXTRACT 

See 

3291 

KOHA 

1791 Kida, T. and Nakayama, S. A CASE OF EXPERIMENTAL 

USE OF KOHA IN THE TREATMENT OF HODGKIN'S 

DISEASE. Rinsyo & kenkyo, 1947, 24: 309-311. 

1792 Suzue, K., Okamura, I. and Ushijima, K. ON 

THE INFLUENCE OF KOHA (A PHOTOSENSITIVE 

COLOURING MATTER) UPON THE TUMOR GROWTH. 

Gann, Tokyo, 1948, 39: 45. Oral administra 

tion of koha caused~Tnhibition of tumors in 

the rabbit and was more effective than local 

application. 

KREBIOZEN 


1793 Bailey, H. KREBIOZEN, KEY TO CANCER? 312p. 

N. Y., Hermitage House, 1955. Written by 

journalist in popular style. Some documen 

tation in the form of case histories and 

reports from various committees. 

1794 COUNCIL ON PHARMACYAND CHEMISTRY. COMMITTEE 

ON RESEARCH. STATUS REPORT ON "KREBIOZEN". 

J. Am. M. Ass., 1951, 147: 864-873. 3 refs. 

1795 Rhoads, C. P. KREBIOZEN. Science, 1951, 114: 

285-286. Discussion by A. C. Ivy: p. 286. 

1796 

Schnitz, H. E. and 

MENT OF CERVICAL 

Smith, C. 

CARCINOMA 

J. PRIMARY TREAT 

WITH "KREBIOZEN." 

J. Am. M. Ass., 1952, 148: 843-844. There 

was no evidence that "krebiozen" had any 

curative or destructive effect on the lesion 

in this case. 

1797 Szujewski, H. A. KREBIOZEN IN TREATMENT OF 

CANCER; COMPARISON WITH OTHER THERAPY AS 

DETERMINED BY ENZYME ANALYSIS. J. Am. M. 

Ass., 1952, 148: 929-933. 

stracted in:~CKem. Abstr., 

7 refs. Ab 

1952, 46: 5184c. 

Krebiozen was tested in 70 cases.In no 

single case was complete or partial inhibi 

tion of the cancer demonstrated. No change 

in cell structure or tumor architecture was 

evident. 

1798 Winternitz, M. C. "KREBIOZEN". J. Am. M. Ass., 

1951, 147; 1297. 

KR SERUM 

see TRYPANOSOMA CRUZI 

LACCA JAPÃ“NICA 

1799 Yoshizaki, M. THE EFFECT OF LACCA JAPÃ“NICA ON 

YOSHIDA SARCOMA. Gann, Tokyo, 1952, 43: 177. 

In Japanese. Tumor cell growth was inhibited 

50% after the injection of Lacea JapÃ³nica 

compound into the abdominal cavity of Yoshida 

sarcoma bearing animals; a 25% damaging effect 

is obtained by subcutaneous injection. The 

active agent of the compound is thought to be 

lead. 

LACTIC ACID, SODIUM SALT 

See 

64 

LECITHIN 

See 

64 

LECITHIN, 

FERRO- 

1800 

Heinen, W. and Loosen, H. BEHANDLUNG EINER 

LYMPHOGRANULOMATOSE MIT INTRAVENÃ–SEN EISEN- 

LECITHINGABEN. [TREATMENT OF HODGKIN'S 

DISEASE WITH INTRAVENOUS FERRO-LECITHIN 

INJECTIONS.] Med. Klin., Beri., 1951, 46: 

722. Abstracted in: Excerpta med., SeciT 2, 

1952, 5: No. 2992. "In a case of Hodgkin's 

disease" 5 ml. of 'ferriceli' (62.5 mg. Fe, 

5 mg. lecithin in a 20% dextrose-laevulosesaccharine 

solution) were injected daily for 

10 days. The temperature dropped to normal 

after the first injection and there was 

subjective improvement, increase in appetite 

and weight. The haemoglobin increased. The 

swelling of the lymph nodes in the neck 

subsided. Thirty-eight days after the treat 

ment, temperatures of 39Ã›C. were recorded 

again. The repeated 'ferrlecit' therapy 

was now ineffective." -Excerpta med. 

LEECH EXTRACT â€”¿ TREATMENT 

See 

1693 

LEUCDÃ•E, IODOACETYL 

See



103 

LILY, APRIL RAIN 

see COOPERIA PENDUNCULATA 

LINOLEIC ACID 

1801 

Nosek, J. Z. VLIV LIPIDU NA RUST PRENOSNE 

KRYSl RAKOVINY. [INFLUENCE OF LIPIDS ON THE 

GROWTH OF THE TRANSPLANTABLE CANCER 

Lek. listy, Brno, 1950, 5: 215-217. 

IN RATS.] 

7 reÃs. 

English summary. Abstracted in: Chem. Abstr., 

1955, 49; 486g. 

LIVER AUTOLYSATE 

1802 

Fazio, H. AZIONE DI ESTRATTI ED AUTOLISATI 

EPATICI SULL'ADENOCARCINOMASPERIMENTALE. 

[EFFECT OF HEPATIC EXTRACTSANDAUTOLYSATES 

UPON EXPERIMENTALADENOCARCINOMA.] Neoplasie, 

Tor., 1950, 4: 61-72. 25 reÃs. Hydro-alco 

holic 

liver 

liver extract, 

autolysate in 

antianemic extract 

doses of 0.001-0.1 

and 

cc 

were administered subcutaneously to 48 albino 

rats with transplanted Ehrlich adenocarcinoma. 

The extracts inhibited tumor growth, and the 

autolysate 

time. 

prolonged slightly the survival 

LIVER EXTRACTS 

see also TISSUE EXTRACTS. AF2 


1803 

Pezzoli, A. and Reggiani, E. INFLUENZA DI 

ESTRATTI EPATICI E DI FEGATO STIMOLATO CON 

METILCOLANTRENE SUI TUMORI DA METILCOLAN- 

TRENE. [THE EFFECT OF LIVER EXTRACTS AND 

OF METHYLCHOLANTHRENE STIMULATED LIVER ON 

METHYLCHOLANTHRENE INDUCED TUMORS.] Neo 

plasie, Tor., 1953, 7: 31-40. 

1804 

Soave, F. DISINTEGRATO EPATICO E TUMORI; RI 

CERCHE SPERIMENTALI. [LIVER AUTOLYSATE AND 

TUMORS; EXPERIMENTAL STUDIES.] Neoplasie, 

Tor., 1947, 2: 141-150. 23 reÃs. English 

summary. 

See 

1802 1805 2667 2754 

THERAPY 

1805 

Amersbach, J. C., Walter, E. M. and Sperti, G. S. 

TREATMENT OF BASAL CELL EPITHELIOMA BY IN 

JECTION OF TISSUE EXTRACTS. A PRELIMINARY 

REPORT. 

119-132. 

Arch. Derm. 

40 refs. 

Syph., Chic., 1946, 54: 

1806 

Amersbach, J. C., Walter, E, M. and Sperti, G.S. 

TREATMENT OF BASAL CELL EPITHELIOMA BY INJEC 

TION OF TISSUE EXTRACTS; A FURTHER REPORT. 

Arch. Dermat. Syph., Chicago, 1948, 58: 111- 

117. 4 reÃs. 

l807 

Amersbach, J. C., Walter, E. M., Sperti, G. S. 

and Nutini, L. TREATMENT OF HUMAN MALIGNANCIES 

WITH TISSUE EXTRACTS. Acta UniÃ³ intern, cancr., 

Louvain, 1950, 6: 1073-1079. Intradermal in 

jections of cattle spleen as well as human 

spleen and liver extracts reduced the size of 

basal 

while 

cell epitheliomas in some of 48 patients 

in others complete regression of the 

tumor was observed. Injections of glucose 

had no effect on the tumors. 

LYGRANUM 

1808 

Orsini, O. TRATAMENTO DA LINFOGRANULOMATOSE 

INGUINAL SUBAGUDA PELO LYGRANUM. [THE TREAT 

MENT 

WITH 

OF SUBACUTE 

LYGRANUM.] 

INGUINAL LYMPHOGRANULOMA 

Rev. clin., S. Paula, 1951, 

27: NÂ». 3 4, 11-12. 2 refs. English sum 

mary. One patient was successfully treated 

with 2 intradermic injectians of lygranum 

Squibb. 

LYSINE 

3560 

MAGNESIUM 

1809 

Meyer, B. A. and Exner, G. G. A TREATMENT 

FOR INOPERABLE CANCER AND AN ADJUNCT TO ALL 

OTHER FORMS OF TREATMENT. (AN INTERIM RE 

PORT). Med. Press, 1953, 230: 651-654. 


2j No. 4407. "The parenteral 

Sect. 16, 1954, 

administration 

of an anticancerous agent, a complex of zinc, 

magnesium and ascorbic acid, is described for 

cases of advanced malignant disease, and 

symptomatic improvement claimed." -Excerpta 

med. 

MAGNESIUM 

SALTS 

1810 

Reding, R. RECHERCHE D'UN FACTEUR ANTINÃ‰O- 

PLASIQUE DANS LA FIBRE MUSCULAIRE STRIÃ‰E. 

[STUDY OF AN ANTINEOPLASTIC FACTOR IN THE 

STRIATED MUSCLE FIBER.] Bull. 

cancer, 1949, 36: 292-304. 

Ass. fr. 

1811 

Zavala Muniz, J. CONTRIBUCIÃ“N A LA TERAPÃÛTICA 

DEL CANCER. [CONTRIBUTION TO THE THERAPY OF 

CANCER.] Sem. mÃ©d., B. Air., 1946, 1: 695- 

701. 

See 

3704 

MAGNESIUM SULFATE 

See 

1810 

MALARIA 

see PLASMODIUM 

MALEIC ACID AND DERIVATIVES 

See 

3236 

MALEIMIDE 

1812 

Friedmann, E., Uarrlan, D. H. and Simon-Reuss, I. 

ANTIMITOTIC 

SUBSTANCES. 

ACTION 

Brit. 

OF MALEIMIDE AND 

J. Pharm., 1949, 

RELATED 

4: 105- 

See 

108. tab. 

med., Sect, 

1888 

MALONAMIDE, 

See 

2746 

5 refs. Abstracted in: Excerpta 

2, 1949, 2: No. 4957. 

N, N'-DI-p-CHLOROBENZYL- 

MALONIC ACID 

1813 

Ackermann, W. W. and Potter, V. R. ENZYME IN 

HIBITION IN RELATION TO CHEMOTHERAPY. Proc. 

Soc. Exp. Biol., N. Y., 1949, 72: 1-9. 


2, 1950, 3: No. 4820; Chem. Abstr., 1950, 44: 

674d. 

See 

1000 1001 3134 3135



104 

MALONONITRILES 

1814 Gal, E. H. and Greenberg, D. M. GROWTH-RETARDING 

EFFECT OF SUBSTITUTED MALONONITRILES ON 

TRANSPLANT TUMORS. J. Am. Chem. Soc., 1951, 

73: 502-503. About 50 compounds were tested. 

7T7..p-nitrobenzalmalononitrile produced a 

retardation of growth of about 50% of the 

tumors C3H-S, and Eo771 and about 40% of S-37, 

while the 5-nitrofuranalmalononitrile showed 

70% retardation of growth of C3H-S." 

1815 

Gal, E. M. and Greenberg, D. M. STUDIES ON THE 

BIOLOGICAL ACTION OF MALONONITHILES. III. 

EFFECT OF MALONONITRILE ADMINISTRATION ON EX 

CRETION OF THIOCYANATE IN NORMAL AND WALKER 

CARCINOMA 256-BEARING RATS. Cancer Res., 

1953, 13: 226-230. 12 refs. 

Excerpta" med., Sect. 5, 1954, 


7: No. 3929. 

1816 

Gal, E. H., Fung, F. H. and Greenberg, D. M. 

STUDIES ON THE BIOLOGICAL ACTION OF MALONO 

NITRILES. I. THE EFFECT OF SUBSTITUTED 

MALONONITRILES ON THE GROWTH OF TRANSPLANTED 

TUMORS 565-572. IN MICE. 15 refs. Cancer 1 pi. Res., AbstracteH~in: 

1952, 12: 

Chem. Abstr., 1953, 47: No. 4499ÃŒ. "Sys 

tematic studies on th~e~different substituted 

malononitriles showed that ethoxymethylenemalononitrile 

of the aliphatic series had 

some effect 

carcinoma. 

on the retardation of growth of 

p-Nitrobenzal-, 5-nitrofuranal-, 

and 5-nitro-2-thenylidenmalononitriles re 

tarded the growth of the transplantable car 

cinomas, C3H-S and E 0771 to an even greater 

degree. This effect is attributable to the 

structural properties of the particular com 

pounds rather than to the release of cyanide 

at different rates. Neither sodium cyanide 

nor malononitrile itself showed any 

retardation on the tumors tested." 

growth 

1817 

Gal, E. il. , Fung, F. H. and Greenberg, D. M. 

STUDIES ON THE BIOLOGICAL ACTION OF MALO 

NONITRILES. II. DISTRIBUTION OF RHODANESE 

(TRANSULFURASE) IN THE TISSUES OF NORMALAND 

TUMOR-BEARING ANIMALS AND THE EFFECT OF MALO 

NONITRILES 

574-579. 

THEREON. 

12 refs. 


1818 

Petrakis, N. I,,, Bierman, H. R. and Shimkin, M. B. 

Addendum. SUBSTITUTED MALONONITRILES IN NEO- 

PLASTIC DISEASES IN MAN. Cancer Res., 1952, 

12: 573. 1 rÃ©f. "It is concluded that p-nitro- 

EÃªnzal and 5-nitrofuranalmalononitrile at the 

doses, length of courses, route and vehicles 

employed had no effect upon the specific neo 

plasms observed in nine patients and that no 

toxic effects were elicited." 

MAMMARY GLAND EXTRACTS 

1819 Bracco, G. TUMORI ED ESTRATTI DI MAMMELLA VERGINE 

E FUNZIONANTE; RICERCHE SPERIMENTALI. [TUMORS 

AND EXTRACTS OF VIRGIN AND ACTIVE MAMMARY GLAND; 

EXPERIMENTAL RESEARCH.] Neoplasie, Tor., 1947, 

2: 35-48. 30 refs. Extracts from the virgin 

mammary gland in doses :>f5 mg injected subcutaneously 

into rats with adenocarcinoma, in 

creased the growth of the tumor, caused cachexia.. 

as well as a tendency toward necrotization. Ex 

tracts from functioning mammary glands in doses 

of 10 mg injected subcutaneously inhibited the 

growth of adenocarcinoma and decreased cachexia. 

A total of 40 rats were used in the experiment. 

MANGANESE 

See 

1777 

MEGAPHEN 

2-CHLORO-10-(3-DI- 

see PHENOTHIAZINE, 

METHYLAMINOPROPYL)- 

MENADIONE, 

See 

1790 

ME PACHINE 

see QUDJACRINE 

MERCURY 

BISULFATE 

COMPOUNDS 

1820 

Miyaji, S.. Sonehara, S.. Hosoda, T., Kashima 

R. and Nitta, A. THE INHIBITORY EFFECT OF 

MERCURY COMPOUNDS ON THE GROWTH OF YOSHIDA 

SARCOMA AND THE HUMAN MALIGNANT GROWTH; A 

PRELIMINARY TRIAL. Gann, Tokyo, 1954, 45: 


See 

3138 

METABOLISM STUDIES (INCLUDING EFFECTS 

ON THE METABOLIC PROCESSES) 

OF AGENTS 

For the metabolism of a specific compound see under 

the compound. 

1821 

Bendich, A. NUCLEIC ACIDS, ISOTOPES, AND THE 

CANCER PROBLEM. Baskerville 

1: 13-18. 12 refs. 

Chem. J., 1950, 

1822 

Brown, G. B. THE BIOSYNTHESIS OF NUCLEIC ACIDS 

AS A BASIS FOR AN APPROACH TO CHEMOTHERAPY 

Ann. N. York Acad. Sc., 1954, 60: 185-194 23 

refs. 

1823 

Brown, G. B. METABOLIC BASIS FOR OPTIMISM 

REGARDING CHEMOTHERAPY WITH NUCLEIC ACID 

DERIVATIVES. In: Antimetabolites and 

cancer. (Rhoads, C. P. ed.) Wash., D. C. 

Am. Ass. Advanc. Sc., 1955, 285-299. 

47 refs. 

1824 Dustin, P., Jr. LES POISONS MITOTIQUES "RADIO- 

MIMÃ‰TIQUES" ET LE MÃ‰TABOLISME DES NUCLÃ‹OPRO- 

TEINES. ["RADIOMIMETIC" MITOTIC POISONS AND 

THE METABOLISM OF NUCLEOPROTEINS.] Rev. 

belge path., 1952, 22: 55-69. 60 refs. 


1825 

Gilbert, L. M.., Overend, W. G. and Webb, M. 

THE INHIBITION 0F PANCREAS DEOXYRIBONUCLEASE. 

Exp. Cell Res., 1951, 2: 349-365. 38 refs. 

See: 'The influence of mitotic inhibitors 

on the hydrolysis of deoxyribonucleohistone 

by deoxyrlbonuclease," p. 358-361. The action 

of the -SH reactants chloracetophenone, iodoacetic 

acid and iodoactamide, which cause 

telophase inhibition in cells in chick 

cultures, and the action of colchicine, 

tissue 

aminopterin 

and certain nitrogen Bustards were 

studied. 

1825a 

Grundland, I. ESSAIS D'Ã‰LABORATIONDES VOIES 

D'APPROCHE A LA CHIMIOTHERAPIE DU CANCER; 

ACTION SUR L'EAU D'HYDRATATION DES TISSUS 

NEOPLASIQUES; ACTION SUR LES PROTEINES. 

[APPROACHES TO THE CHEMOTHERAPY OF CANCER; 

ACTION ON THE WATER CONTENT OF NEOPLASTIC 

TISSUES; 

Experientia, 

ACTION ON THE PROTEINS]. 

Basel, 1955, II: 118-122. 

1825b 

HÃlscher, H. A. OBER DEN NACHWEIS VON DEHYDRASEN 

fER TUBORZELLE 

DEMONSTRATION 

MITTELS TETRAZOLIUMSALZEN. 

OF DEHYDROGENASES IN TUMOR CELLS 

WITH TETRAZOLIUM SALTS]. Zschr. Krebsforsch., 

1950, 

Chen. 

56: 587-595. 

A~Estr., 1950, 


44: No. 85011. 

in:



105 

METABOLISM STUDIES (INCLUDING EFFECTS OF 

AGENTS ON METABOLIC PROCESSES) (Continued) 

1826 

Potter, V. R. ENZYMES, GROWTHANDCANCER. 

71 p. Springfield, C. C. Thomas. 1950, 

(American lectures series. No. 75) 61 

refs. See "Enzyme inhibition and chemo 

therapy" 1950, p. 53-61. 

1827 

Potter, V. R. STUDIES ON THE ALTERNATIVE 

PATHWAYS OF GLUCOSE METABOLISM IN RELATION 

TO THE DESIGN OF SEQUENTIAL BLOCK CHEMO 

THERAPY. Proc. CaÃ±ad. CÃ¡ncer Coni., (1954), 

1 Conf., 290-300. 34 refs. 

1828 

Skipper, H. E., Mitchell, J. H., Jr., Bennett, 

L. I.., Jr., Newton, M. A., Simpson, L. and 

Eidson. M. OBSERVATIONS ON INHIBITION OF 

NUCLEIC ACID 

ISTRATION OF 

SYNTHESIS RESULTING FROM ADMIN 

NITROGEN MUSTARD, URETHAN, COL- 

CHICINE, 2,6-DIAMINOPURINE, 8-AZAGUANINE, 

POTASSIUM ARSENITE, AND CORTISONE. Cancer 

Res., 1951, 11: 145-149. Nucleic acid syn 

thesis was InlTibited in vivo by 2,6-diaminopurine, 

8-azaguanine, cortisone, potassium 

arsenite, urethane, and nitrogen mustard but 

not by benzene and colchicine. 

1829 

Tanaka, S., Shimizu, T., Ishioroshi, Y., Koike, 

M. and Hirako, S. ENZYMATIC Al,RESEARCH ON 

VARIOUS 

M. Se., 

ANTICARCINOGENIC DRUGS. Nagoya J. 


in: Chem. Abstr., 1953, 47: 10117c. 

1830 

Tanaka, S., Shimizu, T., Koike, M., Shimizu, H. 

and Isogai, F. 

ANTICARCINOGENS. 

ENZYMATICAL STUDIES ON SOME 

Gann, Tokyo, 1952, 43: 168- 

169. In Japanese. Among the compounds tested, 

in vivo, were malic acid, 4-amino pterine, 

2-6 diaminopurine, urethane and cytochrome C. 

See 

369 

3026a 

METALS 

810 

3036a 

1813 2613 3018a 

see also ORGANOMETALLIC COMPOUNDS; PARACELSUS 4 

1831 

Dubois-FerriÃ¨re, H. CONSIDÃ‰RATIONS SUR LA 

PATHOGÃ‰NIE ET LE TRAITEMENT DES LEUCEMIES. 

[CONSIDERATIONS OF THE PATHOGENESIS AND 

TREATMENT OF LEUKEMIA.) Rev. mÃ©d. Suisse 

rom., 1953, 73: 681-701. 32 refs. 

Abstracted iHT Leukemia Abstr., 1953, 1^: 

No. 413. 

1832 

Datola-furiÃ¨re. H. ESSAI DE TRAITEMENT DES 

HEMOPATHIES MALIGNES PAR LA CORTISONE. LE 

TRIETHYLENE MELAMINE ET LES OLIGOMETAUX. 

[THERAPY OF MALIGNANT DISEASES OF THE BLOOD 

WITH CORTISONE, TRIETHYLENE MELAMINE AND 

THE OLIGOMETALS.] Schweiz, med. Wschr., 

1951, 81: 1235-1237. 

1833 

Dubois-Ferriere, H. ESSAI DE TRAITEMENT DU 

LYMPHOGRANULOME DE HODGKIN,PAR LA 

ASSOCIEE AU TRI-ETHYLENE-MÃ‰LAMINE 

CORTISONE, 

ET AUX 

MÃ‰TAUX IONISÃ‰S. [COMBINED TREATMENT OF 

HODGKIN'S DISEASE WITH CORTISONE, TRIETHYLENE 

MELAMINE AND IONIZED METALS.] 

1951, 22: 180-191. 21 refs. 

Sang, Par., 


Index analyt. cancer., Par., 1952, 23: No. 

1098. 

1835 

Dubois-FerriÃ¨re, H. and Sarasin, R. RÃ‰MISSION 

DE LEUCEMIES TRAITEES PAR L'ASSOCIATION DE 

CYTOSTATIQUES ET DE CYTOPHYLACTIQUES. [RE 

MISSION IN LEUKEMIAS TREATED BY A COMBINATION 

OF CYTOSTATICS AND CYTOPHYLACTICS. 

Bern, 1952, 41: 57-64. 15 refs. 

] Praxis, 

Abstracted 

in: LeukemiaTbstr., 1953, 1.:No. 144. 

See 

123 

MET-FOL-B 

see PTEROIC 

METHIONINE 

1836 

Finucci, V. and Merlo, G. AZIONE DELLA METIONINA 

SULLA CRESCITA DELL'ADENOCARCINOMA DEL TOPO. 

[EFFECT OF METHIONINE UPON THE GROWTH OF RAT 

ADENOCARCINOMA.1 Neoplasie. Tor., 1950, 4: 

189-200. 11 refs. Methionine in doses or 

0.2 cc injected into 13 rats increased the 

weight of the tumor, did not prolong survival 

time and promoted decrease in body weight. 

1837 

Kutschera, R. DER GEHALT DES BLUTES AN REDUZIERTEM 

GLUTATHÃ•ON UNTER EINWIRKUNG VON METHIONIN UND 

CYSTIN. [REDUCED GLUTATHIONE CONTENTS OF THE 

BLOOD 

83 1. 

DUE TO THE ACTION OF METHIONINE AND CYSTINE.] 

(Inaug. -Diss. -Mainz.) 189 refs. See 

p. 61-62, description of a case of bile duct 

carcinoma with extensive liver mÃ©tastases. 

See 

688 

METHYLENE 

BLUE 

1838 

Finucci, V. and Bonvino, G. AZIONE DEL BLU DI 

METILENE SULLA CRESCITA DELL'ADENOCARCINOMA 

DI EHRLICH. [EFFECT OF METHYLENE BLUE UPON 

THE GROWTH OF EHRLICH ADENOCARCINOMA. ] 

Neoplasie, Tor., 1950, 4: 201-208. 7 refs. 

MÃ©thylÃ¨neblue in 1:10,0~00 aqueous solution 

injected into 18 albino rats showed an in 

crease in the growth of the adenocarcinoma, 

a decrease in the body weight and no effect 

on the survival time of the animals. 

1839 Pakenham-Walsh, R. TREATMENT OF RODENT ULCER 

BY INJECTIONS OF METHYLENE BLUE AND HYDROGEN 

PEROXYDE. Medical Press, Lond., 1947, 109: 

246-247. 

MIRACIL 

See 

1923 

1834 

Dubois-Ferriere, H. QUELQUES APPLICATIONS CLI 

NIQUES DE LA CYTOPHYLAXIE, METHODE BIOLOGIQUE 

DE TRAITEMENT. [CLINICAL USE OF CYTOPHYLAXIS, 

A BIOLOGICAL THERAPEUTIC 

Bern, 1951, 40: 443-445. 

METHOD.] 

15 reÃs. 

Praxis, 

MIRACIL D 

l-DIETHYLAMDJOETHYLAMINO-4- 

see XANTHONE, 

METHYLTHIO- 

ACID, N10-METHYL-



106 

MISTLETOE 



1840 

Chernov, V. A. PR{1Â£ENENIEPREPARATOV OMELY V 

EXPERIMENTAL! NOI KHIMIOTEKAP1I OPUKHOLEI. 

[APPLICATION OF MISTLETOE PREPARATIONS IN 

CANCER CHEMOTHERAPY.] Tr. Akad. med. nauk 

SSSR, Vopr. onkol., 1954, No. 7, 139-150. 

8 refs. The literature on the application 

of Viscum album L. as a tumor inhibiting 

agent is reviewed and a report is given 

on results obtained in using omelan, the 

aqueous extract of the yellow mistletoe 

flower, in 0.1 g ampuls injected intravenously 

into 244 mice. In 13 series of experiments 

it was 

of rat 

found that omelan inhibited the growth 

sarcoma M-l, sarcoma 180, Ehrlich 

carcinoma transplanted subcutaneously and 

adenocarcinoma of mouse mammary gland. The 

omelan derivatives, toxomelin and necromelin 

were most effective in adenocarcinomas and 

were without toxic effect on the rest of the 

organism. Omelan distroyed the tumor tissue, 

caused severe necrosis around tumor edges 

and inflammation. 

1841 

Chernov, V. A. VLIIANIE PREPARATOVOMELYNA 

METASTAZIROVANIEKROLICH'EI OPUKHOLIBROUNA- 

PIRS. [THE EFFECT OF MISTLE-TOE PREPARATIONS 

UPON THE METASTASIZINGOF BROWN-PEARCETUMOR 

OF THE RABIlIT.] Vopr. onkol., 1955, 1: No. 

4, 38-48. 5 refs. Two mistle-toe extracts, 

nekromelin and toksomelin were tested both 

in vivo and in vitro on Brown-Pearce rabbit 

tumors. Nekromelin increased the mÃ©tastases, 

while toksomelin even in small doses inhibi 

ted mitosis. 

THERAPY 

1842 Brtck, D. ANTWORT AUF HOLTZAPFELS BEMERKUNG 

ZUM ARTIKEL VON D. BRÃœCK: KASUISTISCHER 

BEITRAG ZUR KARZINOMBEHANDLUNGMIT PLENOSOL 

IN HEFT 7 (1950); ZUGLEICH EINE ERGÃ„NZUNG. 

[ANSWER TO HOLTZAPFELS COMMENTON MY ARTICLE 

REPORTING THE USE OF PLENOSOL IN THE TREAT 

MENT OF CANCER (NO. 7, 1950); WITH SUPPLEMEN 

TARY REMARKS.] Hippokrates, 1950, 21: 548- 

549. 

1843 

BrUck, D. PLENOSOLTHERAPIE DES KARZINOMS IN 

DER PRAXIS. [PLENOSOL THERAPY OF CARCINOMA 

IN GENERAL PRACTICE.] Hippokrates, Stuttg., 

1954, 25: 80-82. 

1844 

Dewulf, L. OVER DE BEHANDELING VAN VERGEVORDERDE 

CARCINOMEN MET VISCUM 

TREATMENT OF ADVANCED 

ALBUM EXTRACT. [THE 

CANCER WITH EXTRACT OF 

VISCUM ALBUM.] Belg. tschr. geneesk., 1953, 

9: 459-465. Case histories are given for 8 

patients. Phenosol intravenously or locally 

injected into the tumor gave doubtful results. 

Pain was sometimes lessened. Necrosis occurred 

after local injection. 

1845 

Leroi, A. and May, H. von VISCUM ALBUMBEHAND 

LUNG BEI BLASENTUMOREN. (VISCUM ALBUM THERAPY 

IN TUMORS OF THE BLADDER.] 

Stuttg., 1952, 23J 209-216. 

Hippokrates, 

6 refs. In 6 

patients treatment caused regression or inhi 

bition of tumor growth. 

1846 Meythaler, F. and HÃ¤ndel, F. DIE KARZINOMBE 

HANDLUNG MIT PLENOSOL. [CANCER THERAPY 

WITH PLENOSOL.] Deut. med. Wschr., 1952, 

77; 1320-1323. 24 refs. 

1847 ~ 

Roseler, W. BEITRAG ZUR THERAPIE DES INOPERABLEN 

TUMORS. [CONTRIBUTION TO THE TREATMENT OF IN 

OPERABLE TUMORS.] Zbl. Gyn., 1949, 71: 1197- 

1202. 22 refs. Plenosol brought about a 

general improvement, freedom of pain and a 

desiccation of the ground of the carcinoma. 

1848 

RÃseler, W. B. ZUR KARZINOMBEHANDLUNG MIT PLENOSOL 

[CANCER TREATMENT WITH PLENOSOL.] Arztl. Prax 

Bad Worish., 1950, 2: No. 48; 2, 10. 

1849 

Rothmann, A. and Klein, K. VERGLEICHENDE UNTER 

SUCHUNGEN AN HAUTMETASTASEN EINES MALIGNEN 

MELANOMS NACH INJEKTIONEN VON PLENOSOL UND 

URETHAN. [COMPARATIVE EXPERIMENTS CONCERNING 

SKIN METASTASES OF A MALIGNANT MELANOMA FOL 

LOWING INJECTIONS OF PLENOSOL AND URETHANE ] 

Med. Klin., Beri., 1952, 47: 1218-1221. 

29 refs. 

into the 

Injections of pTFnosol or of urethane 

skin mÃ©tastases of 18 patients with 

cylindromas produced necrosis of the central 

part of the mÃ©tastases; infiltration of the 

cells was stopped and an increase of eosinophils 

in the surrounding 

observed. 

inflamed tissue was 

1850 

RUPP, L. and Siegert, A. ÃœBER DIE WIRKUNG DES 

PLENOSOLS BEI COLLUM- UND MAMMA-CARCINOM- 

REZIDIVEN. [EFFECT OF A MISTLETOE EXTRACT 

('PLENOSOL') IN RECURRENCES OF CERVICAL AND 

MAMMARY CARCINOMA.] Ther. Gegenwart, 

91: 251-255. Abstracted in: Excerpta 

1952 

med. 

Sect. 2, 1953, 6: No. 5124. Plenosol caused 

in 70% of cases a subjective improvement, 

gain in weight, temporary arrest of tumor 

growth and sometimes analgesic effects. 

IbSl 

Tosetti, K. MISTELEXTRAKT UND VITAMIN A IN 

DER BEHANDLUNG DER WEIBLICHEN GENITALKARZI 

NOME. [MISTLETOE EXTRACT AND VITAMIN A IN 

THE TREATMENT OF GENITAL CARCINOMA IN WOMEN.] 

Zbl. Gyn., 1954, 76: 509-514. 18 refs. 

Plenosol with high~doses of vitamin A and C 

was used in incurable cases and as a pretreat 

ment of operable patients. Most of the 73 

patients treated showed marked general im 

provement, diminution of pain and prolonga 

tion of life. Tumors did not regress. 

MITOMYCIN 

1852 

Vaniamolo, T., Yamaoka, S., Umezawa, H., Takeuchi 

T. and Nitta, K. EFFECTS OF MITOMYCIN AND SOME 

OTHER SUBSTANCES PRODUCED BY STREPTOMYCES UPON 

YOSHIDA SARCOMA. Gann, Tokyo, 1953, 44: 357- 

359. In Japanese. 

MITOSIS STUDIES 

see alsoMODE OF ACTION 

For the mitotic effects of a particular 

compound see under the name of the 

compound. 

1852a 

Beuttel, E. MITOSEGIFTE. [MITOSIS POISONS.! 

SÃ¼ddeut. Apoth. 

refs. 

Ztg., 1946, 86: 56-58. 

â€”¿ 

23 

1853 

Binazzi, M. and Tosti, A. INDAGINI CITOLO- 

GICHE INTORNO ALL'AZIONE DELLE RADIAZIONI 

PLESIOROENTGEN E DI ALCUNI ANTIMITOTICI 

SULLE NEOPLASIE EPITELIALI DELLA CUTE 

[CYTOLOGICAL RESEARCHES ON THE EFFECT OF 

PLESIOROENTGEN RADIATIONS AND OF SOME ANTI- 

MITOTICS IN EPITHELIAL NEOPLASMS OF THE 

SKIN.] Riv. biol., 1953, 45: 403-455 

7 pi. 107 refs. EnnJish sÃ¼mmarv. 

1853b 

Cramer, H. KREBSHEMMENDE SUBSTANZEN UND FAK 

TOREN. [CANCER INHIBITING AGENTS AND FACTORS.! 

Abh. deut. Akad. Wiss., Kl.med. Wiss., (1953) 

1954, 1. Sekt, 107-118. 

1853a 

Chury, J. NÃ‰KOLIK NOVYCH POZNATKÃš NA POLI MITO- 

SFCMTTÃ•lT^DSoT



107 

MITOSIS STUDIES (Continued) 

1854 

Druckrey, H., Danneberg, P. and SchmÃ¤hl, D. 

ZELLTEILUNGS-HEMMENDE GIFTE. VERSUCHE AN 

SEEIGELEIERN. [MITOTIC POISONS. EXPERI 

MENTS ON SEA-URCHIN EGGS.] Arzneimitt. 

Forsch., 1953, 3: 151-161. 67 reÃs. 

Abstracted in: Cnem. Abstr., 1953, 47: 

No. 6553h. The toxicity and activity as 

mitotic poisons of about 400 organic com 

pounds Â»ere studied. 

1854a 

Firket, H. Â» PROPOS DES POISONS MITOTIQUES. 

[MITOTIC POISONS.] Bruxelles mÃ©d., 1951, 



1855 

Gavaudan, P. PHARMACODYNAMIE DE L'INHIBITION 

DE LA CARYOCINESE. [PHARMACODYNAMICS OF THE 

INHIBITION OF CARYOKINESIS.j 337p. Paris, 

Librairie le FranÃ§ois, 1947. 455 refs. 

1855a 

Hackmann, C. ZUR FRAGE DER MEDIKAMENTÃ–SEN KREBS - 

BEHANDLUNG. [THE PROBLEU OF CANCER TREATMENT 

WITH DRUGS.] Med. Klin., Beri., 1954, 49: 

1539-1541. 4 refs. A general discussion on 

the action and use of mitotic poisons and 

cytostatic agents and a report of the inhi 

biting effect of Sanamycin on Walker rat 

carcinoma, 

sarcoma. 

Ehrlich mouse carcinoma and mouse 

1855b 

Kirsch, W. MITOSESTADIEN IM PERIPHEREN BLUT 

BEI LEUKÃ„MIEN NACH BEHANDLUNG MIT ZYTOSTATI- 

SCHEN STOFFEN. [MITOSIS STAGES IN THE PERI 

PHERAL BLOOD IN LEUKEMIAS AFTER TREATMENT 

WITH CYSTOSTATIC 

inn. Med., 1950, 

SUBSTANCES]. 

5: 385-386. 

Zschr 

6 refs. 

. ges . 

Abstracted in: Chem. Abstr., 1953, 47: 8256a. 

1855e 

Lohmann, F. E. CHEMISCHE BEEINFLUSSUNG DER 

ZELLTEILUNG. [CHEMICAL INFLUENCE ON CELL 

DIVISION.] Experientia, Basel, 1947, 3: 


med., Sect. 2, 1948, 1_:No. 4555. 

1855d 

LettrÃ©, H. CHEMISCHE UND BIOLOGISCHE UNTER 

SUCHUNGEN ÃœBER MITOSEGIFTE. [CHEMICAL AND 

BIOLOGICAL INVESTIGATIONS OF MITOSIS POISONS.] 

Scientia pharm., 1952, 20: 75-100. 95 refs. 

Review of the classification, structures, 

modes of action, and the use of the various 

mitotic poisons. 

1855e 

LettrÃ©, H. DEMONSTRATION EINES ZEITRAFFERFILMES 

ÃœBER MITOSE UND MITOSEGIFTE. [DEMONSTRATION 

OF A STOP-MOTION FILM ON MITOSIS AND MITOTIC 

POISONS.] Acta UniÃ³ internat, cancr., Louvain, 

1951, 7: 699-700. The film shows the action 

of mitotic poisons, such as colchicine, colchicine 

together with desoxycorticosterone, 

and trypaflavine, on cellular mitosis. 

1855Ã• 

LettrÃ©, H. ERGEBNISSE UND PROBLEME DER MITO 

SEGIFTFORSCHUNG. [RESULTS AND PROBLEMS OF 

MITOSIS POISON RESEARCH.] Naturwissenschaften, 

1946, 33: 75-86. A review article covering 

the composition and action of a great number 

of mitotic poisons on normal and on tumor 

cells. Among the substances discussed are 

organometallic compounds, trypaflavin, colchi 

cine and colchicine derivatives. 

1856 

Â»LettrÃ©,H. MITOSE UND MITOSEGIFTE. [MITOSIS 

AND MITOTIC POISONS.] Film C 599 des Insti 

tuts fur den wissenschaftlichen Film. 

Bunsenstrasse 10, Gottingen, Germany, 1951. 

For description of this motion picture, see 

R. LettrÃ©es "Drug action on cells in vitro," 


1856Â« 

LettrÃ©, H. MITOSEGIFTFORSCHUNG UND IHRE BEZIE 

HUNG ZU PROBLEMEN DER ENZYMFORSCHUNG. [RE 

SEARCH IN MITOSIS POISONS AND THEIR RELATION 

TO ENZYME 

1949, 10: 

RESEARCH.] Erg. Enzymforsch., 

269-301. Approx. 94 refs. A biochemicaT 

review; the problem of antagonism 

to cell proliferation is discussed through 

out . 

1856b 

LettrÃ©, H. ÃœBER MITOSEGIFTE. [MITOTIC POISONS ] 

Erg. Physiol.. 1950, 46: 379-452. Bibliogra 

phy: p. 379-387. 

1856C 

LettrÃ©, H. ÃœBER ZELLTEILUNGSGIFTE. [MITOTIC 

POISONS.] Scientia, Bologna, 1951, 86: 290- 

296. 2 refs. Review of the action Ã”T a 

number of mitotic poisons on normal and 

malignant cells and discussion of their re 

lation to each other. 

1856d 

LettrÃ©, H. ZUM PROBLEM DER KREBSSPEZIFISCHEN 

MITOSGIFTE. [PROBLEMS OF CANCER SPECIFIC 

MITOTIC POISONS.] 

1949, 56: 297-305. 



Abstr. 7T.950, 44: No. 7449b. 

1856e 

Lettre, H. ZUR CHEMIE UND BIOLOGIE DER MITOSE 

GIFTE. [THE CHEMISTRY AND BIOLOGT OF MITOSIS 

POISONS.] Angew. Chem., 1951, 

Essentially the same as report 

63: 421-430. 

In": Scientia 

pharm., 1952, 20: 75-100. 

1856f 

Ludford, R. J. CHEMICALLY INDUCED DERANGEMENTS 

OF CELL DIVISION. 

73: 1-23. 4 pi. 

J. R. Micr. 

Bibliography: 

Soc ., 1953. 

p. Ã•8-22. 

Comprehensive review. Contents: Pioneer work 

on the induction of mitotic aberrations. - 

Dustin's "Poisons Caryoclasiques" (mitotic 

poisons) . - Significance of mitotic poisoning 

under different conditions and in different 

organisms. - Some types of mitotic aberrations 

and the various ways in which they have been 

Induced in different cells. - Various types 

of mitotic derangements induced by the same 

agent. - Relation between chemical constitu 

tion and mitotic poisoning action. Theories 

of mitotic poisoning. - Some general consid 

erations . 

1898g 

Meier, R. and SchÃ¤r, B. DIFFÃ‰RENCIATION DE 

L'ACTION ANTIMITOTIQUE SUR LA CELLULE ANIMALE 

NORMALE,IN VITRO. [DIFFERENTIATION OF ANTI- 

MITOTIC EFFECTS ON NORMALANIMALCELLS IN 

VITRO.] Experientia, Basel, 1947, 3: 358- 

366. Abstracted in: Excerpta med., "Sect. 2 

1948, il: No. 4556. 

1857 

Schinz, H. R. KANKEROGENE, KANKERIZIDE, MUTA- 

GENE UND MORPHOGENE STRAHLEN UND STOFFE IM 

MITOSE VERSUCH. [CANCEROGENIC , CANCEROCIDAL, 

MUTAGENIC AND MORPHOGENIC RAYS AND AGENTS 

IN MITOSIS EXPERIMENTS.] 

1949, 74: 1353-1356. 

Deut. med. Wschr 

See 

1858 


see also MITOSIS STUDIES 

For the mode of action of a particular 

compound see under the name of the 

compound. 

1857a 

AhlstrÃm. C. G. 

A SHORTREVIEWOF MITOTIC 

POISONS. Acta path, microb. scand., Suppl. 

1951, 91: 52-62. A survey devoted to the 

mode ofaction of spindle, interphasic and 

karyoklastic poisons.



1O8 

MODE OF ACTION (Continued) 

1857b 

Boulanger, P. LES POISONS MITOTIQUES: ACTIVITE 

1Ã•ITOCLASIQUE ET CONSTITUTION CHIMIQUE. [MI- 

TOTIC POISONS: CYTOTOXIC ACTION AND CHEMICAL 

CONSTITUTION.] Exposes ann. biochim. med., 

1948, 9: 281-303. Approx. 30 refs. 

1857e 

Boulanger, P. QUELQUES APERÃ‡US SUR L'ACTION 

DES POISONS MITOTIQUES. [SOME NOTES ON 

THE ACTION OF MITOTIC POISONS.] CancÃ©rologie, 

Lille, 1953, 1: 169-175. 8 refs. Abstracted 

In: Excerpta Sed., Sect. 5, 1955, 8: No. 803. 

1858 

Dustin, P., 

ON NORMAL 

Jr. 

AND 

THE ACTION OF MITOTIC POISONS 

PATHOLOGICAL BLOOD-CELL FOR 

MATION. Sang, Par., 1950, 21; 297-330. Dis 

cussion p. 325-327; bibliography p. 328-330. 

1858a 

Dustin, P., Jr. LES POISONS MITOTIQUES ET LE 

MODE D'ACTION DES RADIATIONS IONISANTES EN 

BIOLOGIE. [MITOTIC POISONS AND THE METHOD 

OF ACTION OF IONIZING RADIATIONS IN BIOLOGY.] 

Euclides, 1949, 9: 188-195. 64 refs. 


1859 

Dustin, P. SOME NEW ASPECTS OF MITOTIC POISON 

ING. Nature, Lond., 1947, 159: 794-797. 41 

refs. Abstracted in: Excerpta med., Sect. 2, 

1948, 1: No. 1487; Chem. Abstr., 1947, Â£1: 

No. 59O5h. Review of the mode of action of 

some mitotic poisons, including carbamates 

and cyanates, nitrogen mustards, arsenic and 

dimercaptopropanol(BAL) and ionizing radia 

tions . 

Dustin, P., Jr. .SUR LES BASES EXPERIMENTALES 

DE LA CHIMIOTHERAPIE DU CANCER. ACTION DES 

SUBSTANCES ANTIMITOTIQUES. [EXPERIMENTAL 

BASIS OF CANCER CHEMOTHERAPY: EFFECT OF ANTI- 

MITOTIC SUBSTANCES.] Acta UniÃ³ internat, 

cancr., Louvain, 1953, 9: 739-751. 102 refs. 

English summary. General review and dis 

cussion of the action of mitotic inhibitors, 

radio-mimetic agents, antimetabolites and 

hormones, and the relationship of these 

compounds to each other, 

1860 

LettrÃ©, H. CHEMISCHE BEEINFLUSSUNG VON ZELL 

WACHSTUM UND TEILUNG. [ACTION OF CHEMICALS 

ON CELL GROWTH AND CELL DIVISION.] Verb. 

Deut. ges. inn. Med., 1949, 55: 385-388. 

18Loteless, A. and RÃ©veil, S. NEW EVIDENCE ON THE 

MODE OF ACTION OF 'MITOTIC POISONS.' Nature, 

Lond., 1949, 164: 938-944. 53 refs. 

1861 

Â«Luehrs, Â». ÃœBER DEN WIRKUNGSMECHANISMUS EINIGER 

TUMORHEMMENDER SUBSTANZEN. [ON THE MODE OF 

ACTION OF CERTAIN CANCER INHIBITING SUBSTANCES.] 

Chem. Technik, 1953, 5: 509-515. Abstracted in: 

Ref. zh. Biol., 1955,~No. 2135. 

1862 LÃœhrs. W. ANTIWUCHSSTOFFE. [ANTIGROWTH SUB 

STANCES.] Abh. deut. Akad. Wiss. Kl. med. 

Wiss., (1953) 1954. 1. Sekt, 119-122. 3 refs. 

1882a 

MascrÃ©, M. and Deysson, G. LES POISONS MITO 

TIQUES. [MITOTIC POISONS]. Biol. mÃªd.,Par., 

1951, 40: 323-376. Bibliography p. 367-376. 

Important review including mode of action and 

application. 

1863 

Simon, K. ZUM WIRKUNGSMECHANISMUS EINIGER 

MITOSEGIFTE. [MECHANISM OF ACTION OF SOME 

MITOTIC POISONS.] Krebsarzt, Wien. 1954, 



"Some cytostatics possibly block certain en 

zyme systems. The azo compounds and thiosemicarbazones 

are pronounced 'spindle' 

poisons. The morphological changes resemble 

those see.n with colchicine. Hydrazine is 

one of the most active inhibitors of diamino 

oxydase. It is likely that spindle contrac 

tion can be affected through a histaminehistaminase 

system." -Excerpta med. 

1863a 

Sirtori, C. and Pizzetti, F. SITUAZIONE 

ATTUALE E PROSPETTIVE FUTURE DELLA CHEMO- 

TERAPIA DEL CANCRO. [PRESENT SITUATION 

AND FUTURE PROSPECTS OF THE CHEMOTHERAPY 

OF CANCER.] Tumori, Milano, 1953, 39: 

169-171. 6 refs. A survey of the mechanism 

of action of cellular poisons. 

1864 

Skipper, H. E. A REVIEW: ON THE MECHANISM OF 

ACTION 

Cancer 

OF CERTAIN TEMPORARY ANTICANCER AGENTS. 

Res., 1953, 13: 545-551. 52 refs. 

1864a 

Tazaka, S. and Rokujo, T. INHIBITORY ACTION 

OF THE CHEMICAL COMPOUNDS WHICH INHIBIT 

YOSHIDA SARCOMA. Gann, 


Tokyo, 1954, 45: 

See 

1489a 3051 

MORPHOLINE, 

METHYL 

1865 

Garai, F. and Klingel, H. THE ACTION UPON 

SARCOMAS AND HODGKIN'S DISEASE OF COMPOUNDS 

STRUCTURALLY SIMILAR TO THE NITROGEN MUS 

TARDS. Internat. Cancer Res. Congr., 1947, 

4: 54. An abstract. Mice with transplanted 

s~arcoma 180, rats with transplanted reticulocell 

lymphosarcoma and patients with leu 

kemia, lymphosarcoma and Hodgkin's disease 

were injected with N-methyl tetrahydro 1-4 

oxazine, (also designated as methyl morphaline, 

or 268B). The compound produced 

marked repression of neoplastic growth and 

showed low toxicity. 

MUSHROOM EXTRACT 

1866 

Cantero, A., Azevedo, S. de B., LeSo, A. A. de A. 

EFEITOS ANTINEOPLÃ‚SICOS E NECROSANTES DE NOVOS 

EXTRATOS DE COGUMELO NO SARCOMA DO CAMONDONGO 

(S, 37). OBSERVAÃ‡OES CLÃ•NICAS E EXPERIMENTAIS 

COM SEU EMPREGO Ã‘AS NEOPLASIAS HUMANAS. [ANTI- 

NEOPLASTIC AND NECROTIC EFFECTS OF NEW MUSHROOM 

EXTRACTS ON THE MOUSE SARCOMA (S. 37). CLINI 

CAL AND EXPERIMENTAL OBSERVATIONS ON THEIR 

USE IN HUMAN NEOPLASMS.] Rev. brasil, cÃ¡ncer., 

1952, 5j No. 8, 43-48. 7 refs. 

MUSK GLANDS 

1867 â€ž¿â€ž¿ 

Lenfeld, J. DALSI SDELENI O VLIVU PIZMOVYCH 

Ã•LAZ NA RAKOVINU. [FURTHER INFORMATION ON 

THE EFFECT OF MUSK 

listy, Brno, 1948, 

GLANDS ON CANCER.] Lek. 

3: 351-352. 1 rÃ©f. 

English summary. Rats immune to cancer 

showed musk glands several times the size of 

those not immune. Testosterone produces 

temporary immunity. Implantation of enlarged 

musk gland stops growth of cancer. The 

technical causes of this phenomenon were not 

as yet established. 

1868 

Stefl, J. CANCER RESISTANCE (LETTER TO THE 

EDITOR). Brit. M. J., 1954, 2: 1293. En 

larged musk gland of animals immune to 

Walker carcinoma were transplanted into a 

rat with cancerous growth. The growth re 

gressed and the tumor disappeared. The sub 

stance responsible for this immunity could 

so far not be isolated. Dried musk glands 

of Canadian beaver and similar glands of 

other water rodents were used.



109 

MUSTARD, 

GROUND 

1869 

Hoffmann, H. and Schroder, G. EIN BEITRAG ZUR 

FRAGE DER INDIREKTEN WIRKUNG DER 

STRAHLEN AUF DAS WALKER-KARZINOM 

RÃ–NTGEN 

DER RATTE 

UND EIN VERGLEICH ZUR EINWIRKUNG DES SENFMEHLS 

AUF DAS TUMORWACHSTUM. [ON THE INDIRECT EFFECT 

OF ROENTGEN RAYS ON WALKER CARCINOMA IN RATS, 

AND A COMPARISON WITH THE EFFECTS OF GROUND 

MUSTARD ON TUMOR 

1954, 93j 31-36. 

GROWTH.] 

Approx. 

Strahlentherapie, 

25 refs. 

1870 

Hoffmann, H., SchrÃder, G. and TÃppich, E. 

ZWEITE MITTEILUNG ZUR FRAGE EINER INDIREKTEN 

WIRKUNG DER RÃ“NTGENSTRAHLEN UND ZUR FRAGE 

EINER UNTERSTÃœTZUNG DER TUMORWACHSTUMSHEM 

MENDEN WIRKUNG DER RÃ–NTGENSTRAHLEN DURCH 

ZUSATZLICHE BEHANDLUNG MIT SENFMEHL. [SECOND 

REPORT 

AND ON 

ON AN INDIRECT EFFECT OF ROENTGEN RAYS, 

THE PROBLEM OF REINFORCING THE ANTI- 

CARCINOGENIC EFFECT OF ROENTGEN RAYS BY 

GROUND MUSTARD.] Strahlentherapie, 1954, 

95: 609-614. Approx. 30 refs. Ground mus 

tard compresses inhibit growth of Jensen's 

sarcoma. When roentgen irradiation is com 

bined with ground mustard, the inhibition is 

greater than when either method is used 

alone. Examination of the blood picture did 

not show a difference in the character of 

action of the two methods of therapy. 

MUSTARD OIL 

1871 

NOMA*RA. [THE EFFECT OF ACUTE INFLAMMATION ON 

Goracz. 

PATKANYRÃ•K 

I. A HEVENY 

NOVEKEDÃ‹SÃ‰REÃŠS 

GYULLADAS 

AZ 

HATASA 

EMBERI 

A KISERLETI 

EMIÃ–CARCI- 

THE GROWTH OF EXPERIMENTAL CARCINOMA IN RATS 

AND ON HUMAN BREAST CARCINOMA.] Orv. hetil., 

1952, 93: 251-252. 6 refs. Oleum sinapsis 

syntetTcum applied to the surface of welldeveloped 

Guerin rat tumors brought about in 

flammation which in turn reduced the growth 

of the tumors. 

\_TJTOPLASKINE 

1872 

Van Walleghem, H. ESSAIS PERSONNELS DE TRAITE 

MENT CHIMIOTHÃ‰RAPIQUEDE LA MALADIE CANCÃ‰REUSE. 

[PERSONAL 

THERAPY.] 

ATTEMPT TO TREAT 

Scalpel, Brux., 

NEOPLASMS BY CHEMO 

1955, 108: 329-334. 

rÃ©f. 

MYELOKENTRIC ACID 

1873 

Miller, F. R., Herbut, P. A. and Jones, H. W. 

THE TREATMENT OF LYMPHOBLASTIC LEUKEMIA WITH 

CRUDE MYELOKENTRIC ACID. Blood. Bait., 1947, 


â€¢¿ed., Sect. 2, 1948, l: No. 6591. 

1874 Swan, M. M. and Zelman, S. MYELOKENTRIC ACID 

IN THE TREATMENT OF ACUTE LYMPHOBLASTIC LEU 

KEMIA. Ann. Int. M., 1950, 33: 438-442. 

2 refs. 

MYLERAN 

see BUTANE, 1, 4-DIMETHANESULFONYLOXY- 

1, 4-NAPHTHOHYDROQUIMONE, 2 METHYL DIPHOS- 

PHATE TETRASODIUM SALT â€”¿ EFFECT ON NORMAL 

GROWTH 

1875 Bellairs, R. THE EFFECTS OF TETRA-SODIUM2- 

METHYLl:4-NAPHTHO-HYDROtiUINONEDIPHOSPHATE 

ON EARLY CHICK ANDAMPHIBIANEMBRYOS. Brit. 

J. Cancer, 1954, 8: 685-692. 1 pi. 19 refs. 

1876 

Hughes, A. and Simon-Reuss, I. THE IMMEDIATE 

EFFECT OF SOME PHOSPHORYLATED NAPHTHOHYDRO- 

QUINONES ON DIVIDING CELLS; A STUDY ON LIVING 

CULTURES OF CHICK OSTEOBLASTS. Brit. J. 

Cancer, 1953, T_: 142-150. 3 pi. 9 refs. 

1877 

Mitchell, J. S. and Simon-Reuss, I. COMBINATION 

OF SOMEEFFECTS OF X-RADIATION AND A SYNTHETIC 

VITAMIN K SUBSTITUTE. Nature, Lond. 1947 

160: 98-99. 4 refs. 

EFFECT 


1878 

Dittrich, W. and Schmermund, H. J. ÃœBER DIE 

WIRKUNG DES 2-METHYL-l:4-NAPHTHOHYDROCHINON- 

DIPHOSPHATS (SYNKAVIT) AUF DAS RÃ–NTGEN 

BESTRAHLTE UND UNBESTRAHLTE EHRLICHKARZINOM 

DER MAUS. [THE EFFECT OF 2-METHYL-l:4-NAPH- 

THOHYDROQUINONE DIPHOSPHATE (SYNKAVIT) ON 

IRRADIATED AND NON-IRRADIATED EHRLICH CAR- 

CINOMATA IN MICE.] Strahlentherapie, 1953, 


med., Sect. 16, 1954, No. 2157. 

1879 

â€¢¿Friedmann, E. and Bailey, N. T. J. ACTION OF 

1:4-NAPHTOHYDROQUINONE-DIPHOSPHATE AND ITS 

2-METHYL DERIVATIVE ON IRRADIATED AND NON- 

IRRADIATED RATS WITH JENSEN SARCOMA. Biochim. 

biophys. acta, Amst., 1950, 6: 274. 

1880 

Gellhorn, A. and Cagliano, T. THE EFFECT OF 

TETRA-SODIUM 2-METHYL-l:4-NAPHTHOHYDROQUI- 

NONE DIPHOSPHATE (SYNKAYVITE) ON A VARIETY OF 

MALIGNANT TUMOURS IN EXPERIMENTAL ANIMALS. 

Brit. J. Cancer, 1950, 4: 103-107. 2 refs. 

Intraperitoneal 

daily in doses 

administration of synkayvite 

of 50-125 mg per kg of weight 

was given to mice with the following tumors, 

transplanted subcutaneously in the axillary 

region: Mammary adenocarcinoma 755 in C 57 

mice; 

mice; 

mammary 

sarcoma 

adenocarcinoma Eo 771 in C 

180 in Long-acre mice; or 

57 

Brown-Pearce carcinoma transplanted in the 

anterior chamber of the eye in rabbits. 

No inhibitory action or morphological changes 

were noted in the tumors of the treated 

animals, as compared with the tumors of 

untreated controls. 

1881 

Mitchell, J. S. HISTOLOGICAL CHANGES PRODUCED 

BY LARGE DOSES OF TETRA-SODIUM 2-METHYL-l: 4- 

NAPHTHOHYDROQUINONEDIPHOSPHATE IN SOME HUMAN 

TUMORS. Experientia, Basel, 1949, 5: 293- 



PROCESSES) 

1882 

PÃ©guiron, L. and Neukomm, S. MESURES PHOTO- 

MÃ‰TRIQUESDE LA TENEUR EN ACIDE DÃ‰SOXYRIBO- 

NUCLEÃ•QUEDES NOYAUX DE FIBROBLASTES DE SOURIS 

TRAITES PAR LE SYNKAVIT. [PHOTOMETRICAL 

TERMINATION OF THE DESOXYRIBONUCLEIC-ACID 

DE 

CONTENT 0F SYNKAVIT-TREATED FIBROBLAST NUCLEI 

OF MICE.] Acta anat., 1954, 21: 46-58. 10 

refs. 


1883 Mitchell. J. S. and Simon-Reuss, I. EXPERI 

MENTSONTHEMECHANISMOF ACTIONOF TETRA- 

SODIUM2-METHYL-l:4-NAPHTHOHYDROQUINONE 

PHOSPHATEAS A MITOTICINHIBITORANDRADIO 

SENSITIZER, USINGTHETECHNIQUEOF TISSUE 

CULTURE:EXPERIMENTAL METHODSANDQUANTI 

TATIVERESULTS. Brit. J. Cancer, 1952, 6: 

305-316. 2 pi. Approx. 30 refs.



110 

l, 4-NAPHTHOHYDROQUINONE, 2-METHYL DI- 

PHOSPHATE TETRASODIUM SALT â€”¿MODE 

OF ACTION (Continued) 

1884 

Mitchell, J. S.and Simon-Reuss, I. EXPERIMENTS 

ON MECHANISM OF ACTION OF TETRA-SODIUM 2-METHYL- 

1:4-NAPHTHOHYDROQUINONE DIPHOSPHATE AS A MITOTIC 

INHIBITOR AND RADIOSENSITIZER, USING THE TECH 

NIQUE OF TISSUE CULTURE: RELATION BETWEEN CYTO- 

LOGIC EFFECTS AND CHEMICAL CONSTITUTION. Brit. 

J. Cancer, 1952, 6: 317-338. 3 pi. Approx. 

35 refs. 

1885 

PÃ©guiron, L., Neukonun, S. and Richard, M. SUR 

LE MÃ‰CANISME D'ACTION DU SYNKAVIT (SEL SODIQUE 

DE L'ESTER DIPHOSPHORIQUE DE LA 1,2-NAPHTOHY- 

DROQUINONE). [THE MECHANISM OF ACTION OF 

SYNKAVIT (SODIUM SALT OF THE DIPHOSPHORIC ESTER 

OF 1,2-NAPHTHO HYDROQUINONE).] Arch, internat, 

pharra. dyn., Gand., 1954, 100: 113-119. rÃ©f. 

THERAPY 

1886 

Mitchell, J. S. CLINICAL ASSESSMENT OF TETRA 

SODIUM 2-METHYL-l:4-NAPHTHOHYDROQUINONE DI- 

PHOSPHATE AS A RADIOSENSITISER IN THE RADIO 

THERAPY OF MALIGNANT TUMOURS. Brit. J. 

Cancer, 1953, 7_:313-328. 23 refs. "...in 

travenous administration of this compound 

(Synkavit) has a small but useful effect as 

a clinical radiosensitiser." 

1887 Mitchell, J. S. CLINICAL TRIALS OF TETRA-SODIUM 

2-METHYL-l :4-NAPHTHO-HYDROQUINONE DIPHOSPHATE 

IN CONJUNCTION WITH X-RAY THERAPY. Brit. J. 

Cancer, 1948, 2: 351-359. 25 refs. Abstracted 

in: "Tetra-sodiura-2-methyl-l Excerpta mea., Sect. :4-naphthoh~ydroquinone 

5, 1949, 2: No. 2285. 

See 

diphosphate, a synthetic vitamin K substitute, 

has been used in conjunction with palliative 

X-ray treatment for advanced cancer. A definite 

prolongation of life by about 3 months was 

observed in treated cases of bronchial .carci 

noma, compared with similar cases receiving 

X-ray treatment alone. The substance has a 

very low toxicity." -Excerpta med. 

1790 1877 

NAPHTHOQUINONES 

1888 Friedmann, E., Marrian, D. H. and Simon-Reuss, 

I. HALOGEN DERIVATIVES OF THE 1:4-NAPHTHO- 

QUINONE GROUP AND THE MALEIC ACID SERIES IN 

THEIR ACTION ON THE MITOSIS OF CHICK FIBRO- 

BLASTS. Biochim. biophys. acta, Amst., 1952, 

8: 680-686. 10 refs. 

l-NAPHTHYLAMINE-4, 8-DISULFONIC ACID 

1889 Foulkes, R. H. TEST OF * -NAPHTHYLAMINE-4,8- 

DISULFONATE AGAINST A TRANSPLANTED DERMAL 

SARCOMA. Cancer Res., 1955, Suppl. No. 2, 

53. 

NARCOTINE 

See 

731 

NECROSIN 

1890 

Menkin, V. and Pirovane, L. A. THE EFFECT OF 

NECROSIN ON THE CLEAVAGE FOR FERTILIZED SEA 

URCHIN OVA. Biol. Bull., 1949, 97: 244-245. 

1891 

Â»Menkin, V. EFFECT OF NECROSIN ON SPONTANEOUS 

TUMOURS IN MICE. Proc . Soc . Exp. Biol N Y 


- No-2262; Chem- Abstr" 

1892 

Menkin, V. EFFECT OF NECROSIN ON SPONTANEOUS 

TUMOURS IN SWISS MICE. Nature, Lond., 1949, 

163: 327-328. 4 refs. 

NEOARSPHENAMINE 

1893 

Imagi, S. and Takeoka , O. ON THE INFLUENCE OF 

SEVERAL CHEMICALS UPON THE ASCITES CARCINOMA' 

SOME OBSERVATIONS WITH THE AID OF PHASE MICRO 

SCOPE. Gann, Tokyo, 1954, 45: 498-499. 

In Japanese. 

NETROPSIN 

See 

3047 

NICOTINE 

See 

831 

NILE 

BLUE 

1894 

Lewis, M. R., Sloviter, H. A. and Goland, P. P. 

IN VIVO STAINING AND RETARDATION OF GROWTH 

OF SARCOMATA IN MICE. 

89-96. 21 refs. 

Anat . Ree., 1946, 95: 

1895 

Mimura F., Hamaguchi, S. and Fujiki, T. NILBLAU 

, ., , . , . 

SULFAT: ON THE EFFECT OF NILE BLUE UPON THE 

YOSHIDA SARCOMA. Gann, Tokyo, 1953, 44: 383- 


NIRVANOL 

See 

461 

NITRATES, 

See 

674 

NITRITES 

METALLIC 

1896 

Hesse, G., Pirwitz, J. and Dietzel, O. DBER 

DIE WIRKUNGVON NITRITEN AUF DIE MITOSENDER 

ZELLEN DES EHRLICH-ASCITES-CARCINOMS. [THE 

EFFECT OF NITRITES ON THE MITOSES OF EHRLICH'S 

ASCITES-CARCINOMACELLS]. 

Med., 1950, 115; 350-359. 

Zschr. 

4 refs. 

ges . exp. 

Abstracted 

in: Excerpta 

Chem. Abstr., 

med., 

1950, 

Sect. 

44: 

5, 

No. 

1951, 4: 

7449d . 

No. 83; 

NITROGEN MUSTARD ANALOGS 

1897 

Vermeil, E. M. ANALOGI GORCHICHNYKH GAZOV I 

URETANY PRI LECHENII ZLOKACHESTVENNYKH 

OPUKHOLEI. [NITROGEN 

URETHANE IN TREATMENT 

MUSTARD ANALOGS AND 

OF MALIGNANT TUMORS.] 

Sovrem. probi, onkol., ser. 

5-17. A survey of nitrogen 

A, 1949, No. 2, 

mustard analogs 

in treatment of lymphatic diseases and of 

urethane as applied in chronic myeloid leu 

kemia. The 

non-Russian, 

report is based 

mainly Western 

on trends in 

literature.



Ill 

NITROGEN MUSTARDS 

1898 

Garai, O. NITROGEN HUSTARD. Overseas Postgrad. 

M. J., Lond., 1948. 2: 427-430. pi. 16 reÃs. 


2: No. 3283. The pharmacology, chemical re 

actions and toxic reactions of the nitrogen 

mustards are described and 10 cases illustra 

ting results obtained Â«ith their use in neoplastic 

disorders are presented. 

1899 McHugh. J. M. and Ziehl. F. L. NITROGEN MUSTARDS 

IN NEOPLASTIC DISEASES. Barquette M. Rev., 

1948, 13: 56-61. 24 reÃs. The history, chemis 

try ancT~pharmacology of nitrogen mustard are 

reviewed, necessary precautions for its ad 

ministration are given and two case histories 

are reported. 

1900 

Nabarro, J. D. N. THE NITROGEN MUSTARDS. 

J. Pharm., Lond., 1950, 2: 865-879. 124 refs. 

A review. 

1901 

Plauchu, M., Loisy, C., Lejeune, E. and Eymin, 

C. CONNAISSANCES ACTUELLES SUR L'ACTION DE 

LA MOUTARDE D'AZOTE ET SON APPLICATION DANS 

LE TRAITEMENT DU CANCER DE L'OESOPHAGE. [THE 

EFFECT OF NITROGEN MUSTARDS AND THEIR USE IN 

THE TREATMENT OF ESOPHAGEAL CANCER.] J. mÃ©d. 

Lyon, 1952, 33: 783-796. 23 refs. Abstracted 

in: Excerpta~ied., Sect. 2, 1953, 6: No. 5730. 

1902 Pluygers, E. LA NITRO-VPEHITE; PROPRIETES 

BIOLOGIQUE; APPLICATIONS CLINIQUES; EXPOSE 

DE 27 CAS PERSONNELS; REVUE DE LA LITTÃ‰RATURE. 

[NITROGEN MUSTARD; BIOLOGICAL PROPERTIES; CLI 

NICAL APPLICATION; 27 PERSONAL CASE HISTORIES; 

REVIEW OF THE LITERATURE.] J. beige radiol., 

1949, 32: 38-73. 4 pi. 78 refs. 

1903 

Rhoads, C. P. THE EDWARD GAMALIEL JANEWAY LEC 

TURE. THE SWORD AND THE PLOUGHSHARE. J. 

Mount Sinai Hosp., N. York, 1947, 13: 299- 

309. Abstracted in: Biol. Abstr.,"Bait., 

1949, 23_: No. 26495. 

1904 

Salgado Diez, D. I. MOSTAZAS NITROGENADAS. 

[NITROGEN MUSTARDS.] Farmacoter. actual, 

Madr., 1948, 5: 262-272. 18 refs. Ab 


2: No. 1533; Chem. Abstr., 1948, 42: 8962c. 

1905 

Shore, S. REVIEW OF THE NITROGEN MUSTARDS. 

Hahneman. Month., 1947, 82: 461-470. 

26 refs. A review of the pharmacology, 

toxic effects and the clinical use of the 

nitrogen mustards. 


1906 

Albert, Z. and Brojakowska, M. WPfcYW NITRO- 

GRANULOGENU (IPERYTU AZOTOWEGA) NA WZROST 

PRZESZCZEPIALGEGO MIESAKA CROCKERA U MYSZY. 

[EFFECT OF NITROGEN MUSTARD ON GROWTH OF 

TRANSPLANTED SARCOMA OF CROCKER MICE.] 

Polski tygod. lek., 1949, 4: 969-973. 17 

refs. Nitrogen mustard in doses of 0.5 

mg. was injected subcutaneously or intra 

venously on alternate days into 120 mice 

with Crocker sarcoma. Where nitrogen mus 

tard was injected previous to the tumor 

transplantation, inhibition of the growth 

of the tumor was observed; where injected 

following the transplantation of the tumor, 

the growth of the tumor was promoted. 

1907 

Aleksandrowicz, J. UWAGI NA MARGINESIE PRACY 

PROF. Z. ALBERTA I M. BROJAKOWSKIE1 P.T. 

"WPtYW NITRAGRANULOGENU (IPERYTU AZOTOWEGO) 

NA WZROST PRZESZCZEPIALNEOGO MIESAKA CROCKERA 

U MYSZY.", OGtOSZONEJ W POLSKIM TYGODNIKU 

LEKARSKIM (1949, NR. 33/35). [MARGINAL RE 

MARKS ON THE WORK OF Z. ALBERT AND Ãœ. 

BROJAKOWSKIEJ "THE EFFECT OF NITROGEN MUS 

TARD ON THE GROWTH OF TRANSPLANTED CROCKER 

SARCOMA IN MICE" PUBLISHED IN POLSKI TYGODNIK 

LEKARSKI, 1949, 4: No. 33/35, 969-973.] 

Polski tygod. lek"., 1950, 5: 278-279. 

1908 

Biesele, J. J., Philips, F. S., Thiersch, J. B., 

Burchenal, J. H., Buckley, S. M. and Stock, 

C. C. CHROMOSOME ALTERATION AND TUMOR INHI 

BITION BY NITROGEN MUSTARDS: 

OF CROSS-LINKING ALKYLATION. 

THE HYPOTHESIS 

Nature, Lond., 


in: ChemT Abstr., 1951, 45: 5196b. 

1909 

Boyland, E., Clegg, J. W., Koller, P. C., Rhoden, 

E. and Warwick, 6. H. THE EFFECTS OF CHLORO- 

ETHYLAMINES ON TUMOURS, WITH SPECIAL REFERENCE 

TO BRONCHOGENIC CARCINOMA. Brit. J. Cancer, 

1948, 2: 17-29. 9 refs. 1 pi. Experiments 

on tumor-bearing animals and trials on patients 

with bronchogenic carcinoma using methyl-bis- 

Â¿ -chloroethylamine hydrochloride, tris-/*- 

chloroethylamine hydrochloride and dimethyl- 

/3 -chloroethylamine hydrochloride are des 

cribed. 

1910 

Burchenal, J. H., Burchenal, J. R. and Johnston, 

S. F. CHEMOTHERAPY OF LEUKEMIA. III. FUR 

THER STUDIES ON THE EFFECT OF NITROGEN MUS 

TARDS 

MOUSE 

AND RELATED COMPOUNDS 

LEUKEMIA. Cancer, N. 

ON TRANSMITTED 

Y., 1951, 4: 353- 

356. 8 refs. 

1911 

Burchenal, J. H., Cremer, M. A., Williams, B. S. 

and Armstrong. R. A. STERILIZATION OF LEUKE- 

MIC CELLS 

1951, 11: 

IN VIVO AND IN VITRO. Cancer Res., 

700-705. 18 refs. Abstracted in: 

Excerpta med., Sect. 5, 1952, 5j No. 1939; 

CheÂ«. Abstr., 1952, 46: 4123b. 

1911a 

Burchenal, J. H., Lester, R. A., Riley, J. B. 

and Rhoads, C. P. STUDIES ON THE CHEMOTHERA 

PY OF LEUKEMIA. I. EFFECT OF CERTAIN NITRO 

GEN MUSTARDS AND CARBAMATES ON TRANSMITTED 

MOUSE LEUKEMIA. Cancer, N. Y., 1948. 1: 

399-412. 31 refs. Abstracted in: CheÃ¼S. 

Abstr., 1950, 44: 6532b. 

1912 

Burchenal, J. H., Riley, J. B. and Lester, R. A. 

STUDIES ON THE CHEMOTHERAPY OF TRANSMITTED 

LEUKEMIA IN MICE; NITROGEN MUSTARD DERIVATIVES. 

Acta UniÃ³ internat, cancrum, Brux., 1949, 6: 

448-450. 7 refs. 

1913 

Cornman, 1. CYTOLOGICAL PHENOMENA OBSERVED 

DURING SELECTIVE AND NONSELECTIVE INJURY 

TO MALIGNANT CELLS IN TISSUE CULTURE WITH 

PENICILLIUM EXTRACTS AND 

TARDS. Microfilm Abstr. 

WITH NITROGEN MUS 

Doct. Diss., 1948- 

1949, 9: No. 2, 135. 

1914 Englert, H. K. and Gobel, F. LEUKOSEBEHANDLUNG 

BEIM HUND MIT STICKSTOFFLOST. [TREATMENT OF 

LEUKEMIA IN THE DOG WITH NITROGEN MUSTARD.] 

TierÃ¤rztl. Umschau, 1954, 9: 39-42. 7 refs. 

Lymphoid leukemia in dogs was treated with 

nitrogen mustard injected intravenously. 

Following the treatment there was general 

improvement of the animal, reduction in the 

size of the lymph nodes and improvement in 

the blood picture. But 2 weeks after the 

treatment the animals worsened and had to 

be killed.



112 

NITROGEN MUSTARDS â€”¿ EFFECT ON MALIGNANT 


1915 

Goldin, A., Goldberg, B., Ortega, L. G., 

Fugmann, R., Kaiman, F, and Schoenbach, E, B. 

EFFECTIVENESS OF NITROGEN MUSTARDS IN RETARD 

ING THE GROWTH OF SARCOMA 180 WITH REFERENCE 

TO ROUTE OF ADMINISTRATION, AGE OF TUMORS, 

FOOD INTAKE AND WEIGHT LOSS OF THE MICE. 

Cancer, N. Y., 1949, 2: 865-876. 14 reÃs. 

Abstracted in: Biol. Ã„bstr., Bait., 1950, 

24: No. 4093. 

1916 

Haddow, A. and Timmis, G. M. BIFUNCTIONAL 

SULPHONIC ACID ESTERS WITH RADIOMIMETIC 

ACTIVITY. Acta UniÃ³ internat, cancr., 

Louvain, 1951, 7: 469-471. 2 reÃs. 

On the theory tint radiomimetic properties 

of the nitrogen mustard type of drug may 

depend upon the chemical reactivity 

characteristic 

"ester groups 

of the alkyl chloride moiety 

of appropriate chemical pro 

perties were sought which could be sub 

stituted for the chlorine atoms...Appro 

priate esters of sul phonic, phosphoric 

and sulphuric acids have been made and 

tested, but only the sulphonic esters have 

revealed activity. 

are discussed." 

The biological results 

1917 

Huguenin, R., Truhaut, R, and Saracino, R. 

ETUDES SUR LA CHIMIOTHERAPIE DES CANCERS; 

ACTION DES YPERITES ET DE LEURS DERIVES 

SUR LES NÃ‰OPLASIES DES TISSUS DE SYSTÃˆMES 

ET LES EPITHELIOMAS. [CANCER CHEMOTHERAPY; 

THE EFFECT OF MUSTARD 

ON TUMORS OF SYSTEMIC 

GAS AND 

TISSUES 

ITS DERIVATIVES 

AND EPITHELIO- 

MAS.] Sem. hop., Par., 1949, 25: 3005-3012. 

1918 

Ishidate, M., Sakurai, Y., Yoshida, T., Sato, 

II.. Satoh, H. , Matui, E. and Imamura, H 

EXPERIMENTAL STUDIES ON CHEMOTHERAPY OF 

MALIGNANT GROWTH EMPLOYING YOSHIDA SARCOMA 

ANIMALS. IV. Gann, Tokyo, 1953, 44: 342- 

346. 6 refs. In Japanese. 

1919 

Ishidate, M., Sakurai, Y., Yoshida, T., Satoh, 

H. and Imamura, H. EXPERIMENTAL STUDIES ON 

CHEMOTHERAPY OF MALIGNANT GROWTH EMPLOYING 

YOSHIDA SARCOMA ANIMALS. V. EVALUATION 

AND COMPARISON OF CURATIVE EFFECTS OF COM 

POUNDS TESTED USING THE DIAGRAM OF PERCEN 

TAGE SURVIVAL. Gann, Tokyo, 1954, 45: 484-488. 

In Japanese. 

1920 

Kobayashi, K, EXPERIMENTAL STUDIES ON CHEMO 

THERAPY OF MALIGNANT GROWTHS USING YOSHIDA 

SARCOMAS. ON THE INHIBITING EFFECTS OF A DIS 

TINCTIVE FEATURE OF CYTOLOGICAL STUDIES OF 

NITROGEN-MUSTARD AND ITS DERIVATIVES. 

Tohoku Igaku Zassi, 1953, 48: 101-115. 

4 pi. 28 refs. Abstracte3~in: Chem. Abstr., 

1953, 4J7: 12641C. 

1921 

Kobayashi, Y. EXPERIMENTAL STUDIES ON CHEMO 


SARCOMA. II. ON THE INHIBITING EFFECTS OF 

NITROGEN-MUSTARD AND ITS DERIVATIVES. Gann, 

Tokyo, 1951, 4Â£: 274-275. In Japanese. 

1922 

Peczenik, 0. INHIBITION OF TUMOUR-GROWTH AFTER 

ORAL AND PARENTERAL TREATMENT WITH NITROGEN 

MUSTARDS AND TRIETHYLENEMELAMINE. Brit. J. 

Cancer, 1952, 6: 262-269. 19 refs. Abstracted 

in: Excerpta mÃ«d., Sect. 2, 1954, 7: No. 522; 

Chem. Abstr., 1953, 47: 2380i. 

1923 

Pirwitn, J., SchwÃ¤r, B. and Seyfarth, K. A. 

DAS EHRLICH-ASZITESKARZINOM DER MAUS ALS 

TESTOBJEKT ZYTOSTATISCHER SUBSTANZEN; LOST, 

URETHAN, COLCHICIN, FOLINSAURE, MIRACIL. 

[EHRLICH'S MOUSE ASCITES CARCINOMA AS TEST 

TUMOR FOR CYTOSTATIC AGENTS; NITROGEN MUS 

TARD, URETHANE, COLCHICINE, FOLIC ACID 

MIRACIL.] Mikroskopie, Wien, Sonderbd 3 

1949, 29-42. 4 refs. 

1924 

Shapiro, D. M., Goldin, A., Landing, B. H., 

Bergner, A. D., Faiman, F. and Goldberg, B. 

CANCER CHEMOTHERAPY. ANALYSIS OF RESULTS 

OF DIFFERENT SCREENING TECHNIQUES WITH 

NITROGEN-MUSTARD ANALOGUES. Cancer, N. T., 

1949,2: 100-112. 15 refs. Abstracted in: 


Thirty-six analogues of nitrogeni mustard 

used in this comparison of screening me 

thods. 

1925 

Spitz, S. THE HISTOLOGICAL EFFECTS OF NITROGEN 

MUSTARDS ON HUMAN TUMORS 

N. Y., 1948, 1: 383-398. 

AND TISSUES. Cancer, 


Abstracted inT Excerpta med., Sect. 5, 1949, 

2: No. 1694. 

1326 Tobioka, M. and Ueoka, K. GROWTH INHIBITING 

EXPERIMENTS ON YOSHIDA SARCOMA. Gann, Tokyo, 

1950, 41: 37-44. 13 refs. In English. 

See 

307EFFECT 

2103 ON NORMAL 2121GROWTH 

1927 

*AleksandroÂ»icz, J. and Blicharski, J. ODCZYMY 

NARZADU KRWIOTWORCZEGO U CHORYCH LECZONYCH 

DWUCHLORODWUETYLO-METYLAMINA CZYLI IPERYTEM 

AZOTOWYM. [THE REACTION OF THE BLOOD SYSTEM 

IN DISEASES TREATED WITH NITROGEN MUSTARD.] 

Przegl. lek., Krakow, 1948, 4: 219-223. 

1328 

Charlier, R., Philippot, E., Dunon, G. and 

Bacq, Z. M. ACTION DES YPÃ‰RITES ET DE LEURS 

DÃ‰RIVÃ‰SSUR LES Ã‰LÃ‰MENTSFIGURÃ‰S DU SANG CHEZ 

LE CHIEN. [ACTION OF NITROGEN MUSTARDS AND 

THEIR DERIVATIVES ON THE FORMED ELEMENTS OF 

BLOOD IN THE DOG.] Rev. beige, path., 1949, 

19; 327-338. 13 refs. English summary. 

1029 

Bernardelli, E. and Cessali, C. SUL COMPORTA 

MENTO DEI TESSUTI 

LOGICI ALL'AZIONE 

EMOPOIETICI NORMALI E PATO 

DELL"AZOIPRITE. [THE EF 

FECT OF NITROGEN MUSTARD ON NORMAL AND PATHO 

LOGICAL HEMOPOIETIC TISSUES.] Biol. Int., 

Milano, 1954, 7: 387-406. 73 refs. Abstract 

ed in: Excerpta med., Sect. 5, 1955, 8: No. 

1069. 

1930 

Bodenstein, D. A COMPARISON OF THE EFFECTS OF 

VARIOUS NITROGEN MUSTARD COMPOUNDS ON EMBRY 

ONIC 

91. 

CELLS. 

5 refs. 

J. Exp. 

Abstracted 

Zool., 

in: 

1948, 108: 

Chem.~A"T>str. 

75- 

, 

1948, 42: No. 7887e. 

1931 

Cuclnotta, U. AZOTOIPRITE E GUARIGIONE DELLE 

FERITE. [NITROGEN MUSTARD AND THE HEALING 

OF WOUNDS.] Pat. sper., Tor., 1954, 42: 

13-16. 6 refs. Nitrogen mustard had no 

effect on processes of repair. It may safely 

be used when the recovery process of wounds 

is in progress. 

1932 

De Bruyn, P. P. H. and Robertson, R. C. EFFECTS 

OF X-RAYS AND NITROGEN MUSTARD ON LYMPHATIC 

NODULE 

H. T., 

OF THE RABBIT. Proc. 

1949, 72: 717-718. 

Soc. Exp. Biol.,



113 

NITROGEN MUSTARDS â€”¿ EFFECT 


ON NORMAL 

1933 

Â«Friedenwald. J. S. and Buschke, Â». NUCLEAR 

FRAGMENTATION PRODUCED BY MUSTARD AND NITRO 

GEN MUSTARDS IN THE CORNEAL EPITHELIUM. Bull. 

Johns Hopkins Hosp., 1948, 82: 161-177. 

1934 

Â«Friedenwald. J. S., Buschke, W. and Scholz, R. 0. 

EFFECTS OF MUSTARD AND NITROGEN MUSTARD ON 

MITOTIC AND WOUND HEALING ACTIVITIES OF THE 

CORNEAL EPITHELIUM. Bull. Johns Hopkins Hosp., 

1948, 82: 148-160. 

1935 

Friedenwald, J. S., Buschke, W., Scholz, R. 0. 

and Moses. S. G. SOME EFFECTS OF SULFUR AND 

NITROGEN MUSTARDS ON CELL NUCLEI IN MAMMALIAN 

CORNEA. In: APPROACHES TO TUMOR CHEMOTHERAPY. 

Wash., Am~Ass. Advance. Sc., 1947, p. 358- 

378. 12 refs. 

1*33 

Friedenwald, J. S. THE ACTION OF NITROGEN MUS 

TARDS AND RELATED SUBSTANCES ON CELL DIVISION. 

I. CHEMICAL AND BIOCHEMICAL REACTIONS OF MUS 

TARDS. Ann. N. York Acad. Sc., 1951, 51^: 

1432-1442. 51 reÃs. 

id37 

Â«Geckler, R. P. NITROGEN MUSTARD INACTIVATION 

OF THE CYTOPLASMIC FACTOR KAPPA, IN PARAMECIUM 

AURELIA, VARIETY 4. Science, 1949, 110: 89. 

1'938 

Grundman, E. N-LOST-(N-MUSTARD) WIRKUNG UND 

CHROMONEMALER SPIRALISATIONSGRAD. [N-MUSTARD 

EFFECT AND CHROMOSOME STATE OF SPIRALIZATION.] 


"From caryological tests on the lymph nodules 

punctuate during N-mustard cure, it is con 

cluded that the destruction of the resting 

nuclei without subsequent mitosis is solely 

responsible for the clinical action. Between 

N-mustard sensitivity and the condensation 

or spiralisation grade of the chromosomes, 

there seems to be an inverse proportionality 

which explains the special sensitivity of 

the very early prophase and certain forms of 

the resting nucleiâ€ž" 

1939 

Haddow, A., Kon, G. A. R. and Ross, W. C. J. 

EFFECTS UPON TUMOURS OF VARIOUS HALOALKYLARYL- 

AMINES. Nature, Lond., 1948, 162: 824-825. 


5, 1949, 2: No. 1394. 

1940 

Hettig, R. A., Robertson, G. G. and Cline, 

D. T. EFFECTS OF NITROGEN MUSTARD IN 

JECTIONS ON 

J. Laborat. 

THE EMBRYOS OF PREGNANT RATS. 

Clin. M., 1950, 36:833-834. 

Produced retardation in ossification but 

no changes in the hemopoietic or lymphatic 

tissues. 

1941 

Hunter, 0. B. UNUSUAL CHANGES IN LYMPHOSARCOMA 

UNDER NITROGEN MUSTARD THERAPY. Am. J. Path., 

1948, 24: 670-671. An abstract with discussion. 

A distTn"ct coagulation necrosis of the lymphosarcomatous 

tissue without apparent effect on 

the relatively normal tissue was observed. 

1942 Kindred, J. E. THE BLOOD CELLS AND THE HEMO 

POIETIC AND OTHER ORGANS OF DOGS GIVEN INTRA 

VENOUS INJECTIONS OF 2-CHLOROETHYL VESICANTS. 

A.M.A. Arch. Path., 1949, 4J7: 378-398. tab. 


5, 1949, 2: No. 3551. 

Leibetseder, F. VERÃ„NDERUNGEN DER KNOCHENMARK 

ZELLEN DURCH N-LOST (N-MUSTARD). [MODIFICA 

TIONS OF BONE MARROW CELLS BY NITROGEN MUS 

TARD.] Acta haemat., Basel, 1950, 4: 5-12. 

14 refs. Nitrogen mustard, 1 mg per kg, 

was given to 4 patients with lymphogranulomatosis 

and to one with lymphoepithelial 

carcinoma. Following the treatment, the 

bone marrow cells showed alterations of the 

nuclear volume of the erythroblasts in the 

direction of immaturity, while the nuclear 

volume of the lymphoid reticulum cells re 

mained unchanged. Further studies showed 

that the modifications were due to inhi 

bition of mitosis without disturbance of 

the enucleation process. 

1244 

Masszi, F., NÃ©meth, L,, Seilei, C. and Till, G. 

KISERLETEK KULONBQZÃ’ MITOSIS ES FERMENTGÃ•TLÃ“ 

SZEREKKEL EGYSEJTUEKEN ES Ã„LLATI DAGANATOKON. 

[THE EFFECT OF VARIOUS ANTIMITOTIC AND ENZYME- 

INHIBITING SUBSTANCES ON UNICELLULAR ORGANISMS 

AND ANIMAL GROWTHS.] KÃ•sÃ©rletesorvostud., 


Excerpta 

"The effect 

med.. 

of 

Sect. 

various 

16, 

N-mustard's-alone 

1954, 2: No. 103. 

and 

in combination with various dyestuffs- was 

investigated in Paramecium multimicronucleatum 

and carcinomata in rats and mice. The toxic 

effect increased with an increase in the num 

ber of ethyl chloride groups. N-mustard exerts 

no influence either on Guerin's carcinoma in 

rats or on Ehrlich's carcinoma in mice. A 

transient retardation in the growth of Guerin's 

carcinoma may be obtained by treatment with 

trypan blue. Trypan blue in combination with 

N-mustard increases the tolerance of animals 

to N-mustard, delays the development of growth, 

and increases the survival time." - Excerpta 

med. 

1ÃŒ45 

Ninni, M. and Marinone, G. ULTERIORE CONTRIBUTO 

SPERIMENTALE ALLA CONOSCENZA DELLA FISIOPATOLO 

GIA DELL'ERITROPOIESI; I RETICOLOCITI NELL'IN 

TOSSICAZIONE DA AZOIPRITE. [RECENT EXPERIMEN 

TAL CONTRIBUTIONS TO THE PHYSIOPATHOLOGY OF 

ERYTHROPOIESIS; THE RETICULOCYTES IN NITROGEN 

MUSTARD POISONING.] 

5: 462-465. 4 refs. 

Progr. med., Nap., 1949 

1946 Pizzetti, F., Clerici, E. and Di Pietro, S. 

OSSERVAZIONI SULL'AZIONE DEGLI AZOTOIPRITICI 

SUI LEUCOCITI CIRCOLANTI. Â¡EFFECT OF NITRO 

GEN MUSTARDS ON CIRCULATING LEUKOCYTES.] 

Tumori, Milano, 1954, 40: 528-536. 6 refs. 


1947 , 

Senegas, A. and Pourquier, H. APERÃ‡U SUR L'ACTION 

DES RAYONS X ET DE QUELQUES POISONS MITOTIQUES 

SUR LA 

ACTION 

DIVISION CELLULAIRE. 

OF X-RAYS AND OF SOME 

[SURVEY 

MITOTIC 

OF THE 

POISONS 

ON CELL DIVISION.] 

41-42: 614-619. 

Montpellier mÃ©d., 1952, 

1943 

Skowron, S. and Roguski, H. REGENERACJA I 

HAMOWANIE PODZIALÃ“W KOMÃ“RKOWYCH. [REGENERA 

TION AND INHIBITION OF CELL DIVISION.] Fol. 

biol., Warsz., 1953, 1: 23-29. 13 refs. 


194S 

Tanzi, B. MODIFICAZIONI DI ALCUNE ATTIVITÃ€ 

BIOLOGICHE DI SPERMI IPRITATI. [MODIFICA 

TIONS OF THE BIOLOGICAL ACTIVITY OF SPERM 

TREATED WITH 

biol. sper., 

MUSTARD GAS.] Boll. Soc. Ual. 

1949, 25: 820-822. Abstracted 

in: Chem. Abstr., 1950, 44: 10185Ã•. "Nitro 

gen mustard inhibits in pa"rt the fertilizing 

See 

325 

3374 

power of sperms in dilutions 1:200-1:400. 

Below this concentration it is without effect 

on fertilization..." - Chem. Abstr. 

330 1998 2103 2604



114 

NITROGEN MUSTARDS â€”¿METABOLISM 

1950 

Barbieri. P. AZIONE DELL'AZOTOYPRITE SULL'ATTIVITÃ€' 

IN VITRO DELL 

DIVERSI SIERI 

FOSFATASI 

DI SANGUE 

ACIDE ED ALCALINE DI 

UMANO. [EFFECT OF 

MUSTARD GAS ON THE IN VITRO ACTIVITY OF ACID AND 

ALKALINE PHOSPHATASES OF HUMAN BLOOD.] Tumori, 

Milano, 1950, 24: 131-135. 5 reÃs. Abstracted 

in: Chem. Abstr., 1952, 46: No. 7148Ã•. 

1951 

Barron, E. S. G., Bartlett, G. R. and Miller, 

Z. B. THE EFFECT OF NITROGEN MUSTARDS ON 

ENZYMES AND TISSUE METABOLISM. I. THE EF 

FECT ON ENZYMES. J. Exp. M., 1948, 87: 


med., 1949, Sect. 2, 2: No. 2168. 

1952 

Barron, E. S. G.. Bartlett, G. R., Miller, Z. B., 

Meyer, J. and Seegmiller, J. E. THE EFFECT 

OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE 

METABOLISM. II. 

BOLISM. J. Exp. 

THE 

M., 

EFFECT ON TISSUE META 

1948, 87: 503-519. 10 

refs. Abstracted in: Excerpta med.. Sect. 2, 

1949, 2: No. 2680. 

1953 Barron, E. S. G., Seegmiller, J. E., Mendes, 

E. G. and Narahara, H. T. THE EFFECT OF 

NITROGEN MUSTARDS ON THE RESPIRATION AND 

FERTILIZATION OF SEA URCHIN SPERM AND EGGS. 

Biol. Bull., 1948, 9_4: 267-274. 11 refs. 

1954 

Caputo, A. L'AZIONE INIBENTE DELL'AZOTOIPRITE 

SULLA GLICOLISI AEROBIA DI SEXIONI SOPRAV 

VIVENTI DI SARCOMA DI BOUS E DI TUMORI MESENl'IIMAI.I 

UMANI. [INHIBITING EFFECT OF NITRO 

GEN MUSTARD ON AEROBIC GLYCOLYSIS OF SUR 

VIVING SECTIONS OF ROUS SARCOMA AND OF HUMAN 

MESENCHYMAL TUMORS.] 

37; 325-331. 6 refs. 

Tumori, Milano, 1951, 

Intense inhibition of 

aerobic glycolysis was observed. 

1955 

Caselli, P. AZIONE DELLA AZOTIPRITE SULLA GLI 

COLISI DI TESSUTI NEOPLASTICI EPITELIALI 

UMANI. [ACTION OF NITROGEN MUSTARDS ON GLY 

COLYSIS 

Tumori, 

IN HUMAN EPITHELIAL NEOPLASMS.] 

Milano, 1952, 38: 185-191. 22 refs. 

In the presence of chlÃ´Famines, aerobic and 

anaerobic glycolysis was inhibited in 15 

cases. The inhibition was less than that 

in mesenchymal tumors, lymphosarcomas and 

Hodgkin lymphogranulomas. 

1956 

Hardebeck, K. ÃœBER DIE BEEINFLUSSUNG VON PHOS 

FRATASEN DURCH EINIGE MITOTROPE STOFFE. 

Â¡EFFECT OF MITOTROPIC SUBSTANCES ON PHOSPHA 

TASES.] Arch. exp. Path., Beri., 1950, 211: 

57-58. Â¿1refs. Abstracted in: Excerpta 


Abstr., 1951, 45: 3885a. "Phosphatase acti 

vity of dog liver extracts was unaltered by 

treatment with dilute alcoholic solutions or 

extracts of Sinapis albus, geraniol, safranine, 

allyl mustard oil, and nitrogen mustard. Sub 

stances which influence mitotic processes in 

carcinomatous tissues have no general effect 

on phosphatase activity." - Chem. Abstr. 

1957 

Hoet, J. J. and Anderson, H. C. PRODUCTION OF 

CX-PROTEIN IN RABBITS BY CYTOTOXIC AGENTS. 


414. 3 refs. "An acute phase proteTÃ± (Cxprotein) 

has been produced in the rabbit by 

the administration of 3 cytotoxic agents: X- 

radiation, nitrogen mustard, and amethopterine." 

1958 Lenzi, F. STUDIES ON NITROGEN MUSTARD COMPOUNDS. 

Proc. Congr. Internat. Soc. Hemat. (1950) 1951, 

3. Congr., 330. 

1959 Sibata, M. and Sibata, Y. THE CHANGE OF VITAMIN 

C CONTENT OF YOSHIDA SARCOMA DUE TO X-RAY IR 

RADIATION AND NITROGEN-MUSTARD. Gann, Tokyo 

1952, 43: 331-333. In Japanese. 

See 

73 

2606 

962 

3244 


1456 1929 2189 

1960 

Cardinali, G. RECHERCHES EXPÃ‰RIMENTALESSUR LE 

MÃ‰CANISMED'ACTION DES YPERITES A L'AZOTE. 

[EXPERIMENTAL STUDIES ON THE MODE OD ACTION 

OF THE NITROGEN MUSTARDS.] Sang, Par., 1955, 

26_: 220-223. 18 refs. 

1961 

Davis, W. THE REACTION OF NITROGEN MUSTARDS 

WITH MOLECULES OF BIOLOGICAL IMPORTANCE. 

Acta UniÃ³ intern, cancr., 

10: 110-111. 9 refs. 


1962 

*Di Modrone, N. V. MECHANISM OF THE LETHAL 

ACTION OF NITROGEN MUSTARD ON ESCHERICHIA 

COLI. Pubb. Staz. zool. Napoli, 1950, 22: 

Suppl. 94-111. 

1963 HervÃ©, A. L'ACTION DES DERIVES DE L'YPÃ‰RITE. 

[THE ACTION OF MUSTARDGAS DERIVATIVES]. Rev. 

med. LiÃ¨ge, 1948, 3: 84-87. 4 refs. Abstract 

ed in: Excerpta me3., Sect. 5, 1948, 1: No. 1646. 

1984 

Karnofsky, D. A., Graef, I. and Smith, H. i*. 

STUDIES ON THE MECHANISM OF ACTION OF THE 

NITROGEN AND SULFUR MUSTARDS IN VIVO. Am. 

J. Path., 1948, 24: 275-291. pi. 10 refs. 

1965 

Legezinski. VYZKUM 0 PUSOBENI DUSÃ•KATEHO YPERITU 

(CHLORALKYLAMINU) . [INVESTIGATION OF THE ACTION 

OF NITROGEN MUSTARDS.] Cas. lek. cesk., 1950, 


Sect. 2, 1950, 3: No. 6953. "2 : 2'Dichloro- 

N-methyldiethylamine (I) ('nitrogranulogen') 

was studied. Old batches were much more toxic 

than fresh ones. The compound has a moderate 

bacteriostatic and generally inhibitive action 

on various strains (including S. ryphosa, M. 

tuberculosis and R. prowazeki). Highly diluted 

(1 : 20,000 to 1 : 40, 000) I has definite 

bacteriostatic activity against M. pyogenes 

aureus in the presence of penicillin diluted 

to a concentration no longer active against 

this bacterium (probably cumulative effect). 

Increased production 

in animals receiving 

of antibodies was noted 

0.1-0.2 mg. kg. of I." 


1966 

LettrÃ©, H. ZUM MECHANISMUS DER ZYTOSTATISCHEN 

WIRKUNG DER N-LOSTS. [THE MECHANISM OF CYTO- 

STATIC ACTION OF NITROGEN MUSTARD.] 

Naturwissenschaften, 1954. 41: 188. The 

mechanism of the cytostatic action of nitro 

gen mustard is primarily a reaction with the 

cell plasma mitochondria; the nuclear changes 

noted by morphological or cytological methods 

are secondary characteristics. 

1967 

Malaguzzi Valeri, C., Raimondo, F. di and Vicino, 

N. RICERCHE SPERIMENTALI 

D'AZIONE DELLE AZIOPRITIt 

SUL MECCANISMO 

[EXPERIMENTAL RE 

SEARCH ON THE MODE OF ACTION OF NITROGEN MUS 

TARDS.] Progr. med., Nap., 1949, 5: 407-412. 


3: No. 4706.



115 

NITROGEN 

MUSTARDS â€”¿MODE OF ACTION (Continued) 

1968 

Meier, R. and SchÃ¤r, B. EINIGE BESONDERKEITEN 

DER ANTIMITOTISCHEN WIRKUNG VON NITROGEN- 

MUSTARD. [SOME FEATURES OF THE ANTIMITOTIC 

ACTIVITY OF NITROGEN MUSTARD.] Helvet. 

physiol. pharm. acta, 1951, 9: C49-C50. 


Sect. 2, 1952, 5: No. 5934. 

1969 -.â€ž , 

Nermut. M. VLIV HORCICNEHO DUSIKU NA RUST 

B. COLI IN VITRO. [THE EFFECTS OF NITROGEN 

MUSTARD ON B. COLI IN VITRO.] Scripta med., 

Brno, 1950, 23: 481-496. 48 refs. English 

summary. NiÃ®Fogen mustard in amounts of 

0.5-2 mg 10 ml of a liquid medium inhibits 

the growth of B. coli. A concentration of 

3 mg 10 ml kills bacteria. The action of 

nitrogen mustard could not be neutralized 

on adding p-amino-benzoic acid. Neither 

biochemical nor morphological mutations were 

observed. It is suggested that nitrogen 

effects the cell as a whole, particularly 

at the time of cell division. 

1970 

Philips, F. S. and Oilman, A. THE RELATION 

BETWEEN CHEMICAL CONSTITUTION AND 

ACTION OF THE NITROGEN MUSTARDS. 

BIOLOGICAL 

In: AP 

PROACHES TO TUMOR CHEMOTHERAPY. Wash., Am. 

Ass. Advance. Sc., 1947, p. 285-292. 4 refs. 

1971 

Ross, W. C. J. BIOLOGICAL ACTION OF X-RAYS, 

NITROGEN MUSTARDS, DIEPOXIDES AND PEROXIDES. 

Nature, Lond., 1950, 165: 808-809. Abstracted 

in: Excerpta med., SecTT 2, 1951, 4: No. 2212. 

Ross, W. C. J. THE CORRELATION OF CHEMICAL 

STRUCTURE WITH CYTOTOXIC ACTIVITY IN THE 

NITROGEN MUSTARDS. Acta UniÃ³ internat. 

cancr., Louvain, 1954, 1Â£: 159-160. rÃ©f. 

1973 

Â»Spigliati, P. and Vannucchi, V. CONTRIBUTO 

ALLO STUDIO SUL MECCANISMO DI AZIONE DEI 

COMPOSTI AZO-IPRITICI; STUDIO SPERIMENTALE 

SUL COMPORTAMENTO DELLE REAZIONI OSSIDO- 

PEROSSIDASICHE NEI LEUCOCITI DEL SANGUE 

PERIFERICO. [MECHANISM OF ACTION OF NITRO 

GEN MUSTARDS; EXPERIMENTAL STUDY OF OXIDE- 

PEROXYDASIC REACTIONS IN LEUKOCYTES OF 

PERIPHERAL BLOOD.] Minerva med., Tor., 

1950, 41: pt. 2, 679-684. 

122 1635 1761 1908 3255a 


1974 

Auerbach, C. THE INDUCTION BY MUSTARD GAS OF 

CHROMOSOMAL INSTABILITIES IN DROSOPHILA 

MELANOGASTER. 

B, 1947, 62: 

Proc. R. Soc. Edinburgh, Sect. 

307-320. 25 refs. "It is sug 

gested thÃ¤T the primary effect of mustard 

gas and similar chemicals may sometimes con 

sist in the creation of an instability which 

may become stabilized in two different ways: 

either by reverting to the old equilibrium 

of the normal allelmorph, or by 

the new equilibrium of a stable 

attaining 

mutation." 

1975 

Barigozzi, C. LA REAZIONE A SOSTANZE CHIMICHE 

DELLA CROMATINA DI CELLULE NEOPLASTICHE IN 

MITOSI. [CHROMATIN REACTION TO SOME SUBSTANCES 

DURING THE MITOSIS OF NEOPLASTIC CELLS.] 

Biol. lat., Milano, 1949, 1.:527-540. 16 refs. 

1976 

Bennett, I. L. Jr. and Cluff, L. E. INFLUENCE 

OF NITROGEN BUSTARD UPON REACTIONS TO BAC 

TERIAL ENDOTOXINS: SHWARTZMAN PHENOMENON AND 

FEVER. Proc. Soc. exp. Biol., N. Y., 1952, 

81: 304-307. 9 refs. 

1977 

Di Porto, A. MODIFICAZIONI DELLA EUCOLLOIDITA 

DEI PROTIDI SOTTO L'AZIONE DI PREPARATI AZOTO- 

IPRITICI RAFFRONTATE A VARIAZIONI EMATOLOGICHE 

ED ISTOLOGICHE. [MODIFICATION OF 'EUCOLLOIDALITY1 

OF PROTEINS BY NITROGEN MUSTARDS, IN COMPARISON 

WITH HAEMATOLOGICAL AND HISTOLOGICAL CHANGES.] 

Policlinico, sez. med., 1950, 57: 182-192. 

26 refs. English summary. Abstracted in: Chem. 

Abstr., 1951, 45: No. 39461. 

1978 

Di Porto, A. and Bartoli, L. EUCOLLOIDITA DEI 

PROTIDI DOPO TRATTAMENTO AZOTOIPRICO: RAPPORTA 

ALBUMINE-GLOBULINE. [EUCOLLOIDALITY OF PRO 

TEINS AFTER ADMINISTRATION OF NITROGEN MUS 

TARD: THE ALBUMIN GLOBULIN RATIO]. Policlinico, 

sez. med., 1950, 57: 266-270. 9 refs. English 

summary. Abstracted in: Chem. Abstr., 1951, 

45: 6756d. 

1979 

Gjessing, E. C. and Chanutin, A. THE EFFECT OF 

NITROGEN MUSTARDS ON THE VISCOSITY OF THYMO- 

NUCLEATE. Cancer Res., 1946, 6: 593-598. 

7 refs. Abstracted in: Chem. Xbstr., 1947, 

41: No. 7529d. The viscosity of thymus 

nucleate solutions is decreased by ethyl bis 

(jj-chloroethyl)amine , methyl bis (J6-chloroethyl)amine 

and trisxd -chloroethylamine, 

particularly in solutions of low ionic strength. 

The degree and rate of change in viscosity 

depends on the formation of active transforma 

tion products. Findings show the importance 

of the chloroethyl radical in the depolymerizing 

action of the mustards. 

1980 

Hermansky, F.. HermanskÃ¡, Z. ancj Vajach, A. 

VLIV CHLORETHYLAMINO NA KREVNI SRAZLIVOST. 

[EFFECT OF CHLOROETHYLAMINE ON BLOOD COAGU 

LATION.] Cas. lek. 2esk., 1949, 88: 1369- 

1372. 

Sect. 

4 refs. 

2, 1950, 


3: No. 3367. "The clotting 

time and 

sured in 

the recalcification 

13 patients treated 

time 

with 

were mea 

nitrogen 

mustard of Czech origin. The drug caused 

no marked disturbances of the clotting 

mechanism which could be responsible for 

the appearance of haemorrhagic diathesis." 


1981 

Nava, G. CONTRIBUTO ALLA CONOSCENZA DEI RAPPORTI 

TRA PROTEINE E TESSUTO EMOPOIETICO; AZIONE DI 

ALCUNE SOSTANZE EMOCITOTOSSICHE. [RELATION 

BETWEEN PROTEINS AND HEMOPOIETIC TISSUE; EFFECT 

OF SOME HEMOCYTOTOXIC SUBSTANCES.] Gior, clin 

med., 1950, 31: 978-988. 

1982 

â€¢¿Pederzini, A., Colombini, M., Bellesia, L. and 

Lusvarghi, E. AZIONE DELLA AZOIPRITE SULLA 

RESISTENZA OSMOTICA DEI LEUCOCITI DEL SANGUE 

PERIFERICO. [ACTION OF NITROGEN MUSTARD ON 

THE OSMOTIC RESISTANCE OF THE LEUCOCYTES OF 

THE PERIPHERAL BLOOD.] Progr. med., Nap., 


med., Sect. 16, 1954, 2: No. 5022. 

1083 

Â«Schlang, H. A. SHWARTZMAN PHENOMENON. III. 

MODIFICATIONS OF NITROGEN-MUSTARD SUPPRESSION. 


277. 

1S84 

Schlechter, P. ALTERAZIONI MORFOLOGICHE E 

FUNZIONALI DEL SISTEMA RETICOLO-ISTIOCITARIO 

IN ANIMALI SOTTOPOSTI A PROLUNGATO TRATTAMENTO 

CON AZOIPRITI. 

CHANGES IN THE 

[MORPHOLOGICAL AND 

RETICULO-ENDOTHELIAL 

FUNCTIONAL 

SYSTEM IN 

ANIMALS EXPOSED TO PROLONGED TREATMENT WITH 

NITROGEN MUSTARDS.] 

1951, 30: 187-197. 

Boll. Ist. sieroter, milan., 

13 refs. Prolonged ad 

ministration to the rabbit of nitrogen mustard 

caused diminution of the parenchymal cells and 

hyperplasia of the reticuloendothelial system.



116 

NITROGEN MUSTARDS â€”¿ PHARMACOLOGICAL AND 

PHYSIOLOGICAL EFFECTS (Continued) 

1985 

Schulz, F. H. and Kettwig, W. DAS BLUTEIWEISS- 

BILD BEIM INOPERABLEN, MIT STICKSTOFFLOST 

BEHANDELTEN BRONCHIALKARZINOM. [THE ELECTRO- 

PHORETIC BLOOD PROTEIN PATTERN IN INOPERABLE 

BRONCHIAL CARCINOMA TREATED WITH NITROGEN 

MUSTARD.] Zschr. ges. inn. Med., 1954, 9: 


ned,, Sect. 16, 1955, 3: No. 1939. 

1986 

Skowron, S. and Jordan, M. HAMOWANIECZYNNOSCI 

TARCZYCY PRZEZ IPERYT AZOTOWY. [NITROGEN 

MUSTARD AS INHIBITOR OF THYROID ACTIVITY.] 

Bull, internat. Acad. polon. se. cl. med.. 

1949, No. 1-6, 111-113. pi. 4 refs. In 

English. Abstracted in: Chem. Abstr., 1950, 

44: 3156h. 

1987 Spurr, C. L. PHYSIOLOGICAL EFFECTS OF BETA 

CHLOROETHYLAMINES OF INTEREST IN THE CHEMO 

THERAPY OF NEOPLASMS. Texas Rep. Biol. M., 


Chem. Xbstr., 1952, 46: 11460g. A review 

of the chemical alterations produced by 

mustard compounds. These changes are simi 

lar to those induced by X-ray. 

1988 

Â«Storti, E. and Pederzini, A. IL TEST DELLA 

RESISTANZA OSMOTICA DEI GLOBULI BIANCHI NELLA 

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THE LEUCOCYTES DURING NITROGEN MUSTARD THERA 

PY.] Gior. ital. chemioter., 1954, 1: 169- 

171. 

1989 Watkins, W. M. and Â»ormali, A. THE ACTION, IN 

VITRO AND IN VIVO, OF SOME NITROGEN MUSTARDS 

ON HEMOLYTIC COMPLEMENT. Biochem. J., Lond., 


Chem. AÂ¥str., 1953, 47: 2366e. 

See 

831 847 1908 


1990 

Braunsteiner, H., Fellinger, K., Kolder, H. 

and Pakesch, r. GLEICHZEITIGE VERABREICHUNG 

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TANEOUS ADMINISTRATION OF NITROGEN MUSTARD 

AND CORTISONE.] Klin. 

997-998. 1 rÃ©f. 

Wschr., 1952, 30: 

See 

3056 

THERAPY 

19A>id, 

er, A. ERFAHRUNGEN BEI DER BEHANDLUNG VON 

LYMPHOGRANULOM UND LEUKÃ„MIE MIT SENFGASVERBIN 

DUNGEN. [OBSERVATIONS ON THE TREATMENT OF 

LYMPHOGRANULOMA AND LEUKEMIA WITH MUSTARD GAS 

COMPOUNDS.] Schweiz, med. Â»sehr., 1948. 78: 

729-732. 

1992 

Aleksandrowicz, J. ESSAI D'ECLAIRCISSEMENT 

DU MECANISME D'ACTION DE L'YPERITE NITRIQUE 

(NITROGEN MUSTARD, N.M.) ET NOUVELLES POSSI 

BILITÃ‰S DE SON APPLICATION MEDICALE. [AN 

ATTEMPT TO EXPLAIN THE MECHANISM OF THE 

ACTION OF NITROGEN MUSTARD (N.M.) AND THE 

NEW POSSIBILITIES 

Sang, Par., 1948. 

OF ITS MEDICAL APPLICATION.] 

19: No. 2, 94-96. This 

report is essentiaTTy the same as the arti 

cle in: Przegl. lek., Krakow, 1947, 3: No. 

17-18, 549-550. 

1993 

Aleksandrowicz, J. LECHEBNYE SVOÃ•STVA KHLORETIL- 

AMINA. [THERAPEUTIC PROPERTIES OF CHLORETHYL- 

AMINE.] 

31-37. 

Klin, med., Moskva, 1954, 32: 

A review of the application~and 

No. 4, 

effects 

of nitrogen mustards. 

1994 

Aleksandrowicz, J. LECZNICZE WLAÃ¡CIWOÃ¡CI 

IPERYTU AZOTOWEGO. [THERAPEUTIC PROPERTIES 

OF NITROGEN MUSTARD.) Polski tygod. lek., 

1952, 7: 917-922. Review of the use of 

nitrogen mustard in hematological diseases. 

The survey is based on findings in about 

2000 cases in various Polish hospitals. 

1995 

Â»Aleksandrowicz, J. PRÃ“BY WYJAÃ–NIENIA 

MECHANIZMU DZIALANIA IPERYTU AZOTOWEGO 

(NITROGEN MUSTARD N.M.) ORAZ NOWE MOZLI- 

WOSCI JEGO LECZNICZEGO ZAS.TOSOWANIA W 

SWIETLE WLASNYCH SPOSTRZEZEN. [AN 

ATTEMPT TO EXPLAIN THE MECHANISM OF THE 

ACTION OF NITROGEN MUSTARD (N.M.)AND 

ITS NEW THERAPEUTIC POSSIBILITIES IN THE 

LIGHT OF PERSONAL ;UVESTIGATIONS.] 

Przegl. lek., Krakow, 1947, 3: No. 17-18, 

549-550. Abstracted in: Excerpta med. 

Sect. 2, 1948, Â¡L:No. 6739. Sixty-six 

patients with various neoplastic diseases. 

Nitrogen mustard reduced lymph node tumors. 

1996 

Â«Aleksandrowicz, J., Blicharski, J., Kostowski, 

A. and Hanicki, Z. KLINICZNE SPOSTRZEZENIE 

NAD LECZNICZYM WPLYWEMIPERYTU AZOTOWEGOW 

SCHORZENIACH WEZtOW CHtONNYCH. [CLINICAL 

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Balli, L. and Franciosi, A. 

ROENTGENTERAPIA-AZOIPRITE 

L'ASSOCIAZIONE 

NEL TRATTAMENTO DI 

ALCUNE FORME TUMORALI; RELAZIONE E DISCUSSIONE 

SUI RISULTATI OTTENUTI. [ASSOCIATED ROENT- 

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DISCUSSION ON RESULTS.] Radiotherapia, Bologna 

1951, 5: 280-318. 47 refs. 

1998 Beatile, J. W. and Howells, J,. H. BIOLOGICAL 

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Approx. 165 refs. .Abstracted innxcerpta 

med., Sect. 16, 1954, No. 4402. 

1999 

Beecham, C. T., Peale, A. R. and Robbins, R. 

NITROGEN MUSTARD AND X-RAY IN THE TREATMENT 

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Am. J. Obst., 1955, 69: 510-524. 16 refs. 

Discussion: p. 519-55ÃŽ. 

2000 

Bertlich, W. and Heite, H. J. ÃœBERDIE STICK- 

STOFFLOSTBEHANDLUNG DER MYCOSIS FUNGOIDES 

II. HISTOLOGISCHE UNTERSUCHUNGEN AN STICK- 

STOFFLOSTBEHANDELTEN MYCOSIS-FUNGOIDES-KRANKEN 

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123: 

HISTOLOGIC 

481-497. 

STUDIES.] Derm. Wschr., 1951, 

2001 

Binazzi, M. QUALCHE RILIEVO SULLA AZIONE COM 

BINATA DEI RAGGI X E DEGLI ANTIMITOTICI SULLE 

NEOPLASIE EPITELIALI DELLA CUTE. [EFFECT OF 

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NEOPLASMS OF THE SKIN.] Rass. derm, sit., 

1953, 6: 161-166. 

2002 BJurwill, B. BEHANDLING MED N-SENAPSGAS I TVA 

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4 refs.



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NITROGEN MUSTARDS â€”¿ THERAPY 

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2003 Blanco-Soler, C., Otte, J. W. and Madrigal, I. 

EL TRATAMIENTO COMBINADO DEL CANCER DE PULMÃ“N 

INOPERABLE CON MOSTAZA NITROGENADA Y FÃ“SFORO 

RADIOACTIVO. [COMBINED NITROGEN MUSTARD AND 

RADIOACTIVE PHOSPHORUS TREATMENT IN INOPERABLE 

PULMONARY CANCER.] Sem. med., B. Air., 1952, 

59: 427-432. 14 refs. Also in: Rev. clin. 

Ã«spaH., 1952, 46: 284-91. Twelve patients 

treated with 15^*25 mg radioactive phosphorus 

and 30 mg nitrogen mustard showed total re 

mission in 33% of the cases, partial re 

mission in 42%, and no change in 25% of the 

cases. 

2004 

Boland, J. CLINICAL EXPERIENCE WITH NITROGEN 

MUSTARD IN HODGKIN'S DISEASE. Brit. 

Radiol., 1951, 24: 513-515. 1 rÃ©f. 

J. 

2005 

Bromberg-Sznek, S. LECZNICZE STOSOWANIE IPERYTU 

AZOTOWEGO (NITROGRANULOGENU) W RAKU OSKRZELI. 

[MEDICAL APPLICATION OF NITROGEN MUSTARD IN 

BRONCHIAL CANCER.] Polski tygod. lek., 1953, 

8: 136-139. 8 reÃs. Two male patients, aged 

52 and 70, with inoperable bronchial cancer 

were treated with nitrogen mustard, in daily 

doses of 3 mg for eleven days. The red blood 

cell count decreased and the general condition 

of the patients improved. 

2006 Burchenal, J. H., Myers, W. P. L., Craver, L. F. 

and Karnofsky, D. A. THE NITROGEN MUSTARDS 

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1949, 2: 1-17. 28 refs. Treatment of 

N. Y., 

38 

cases of leukemia with methyl-bis ( /3 -chloroethyl)amine 

or tris (^ -chloroethyl)amine 

is described. An additional 89 cases reported 

in the literature are reviewed. Experience 

with 4 other nitrogen mustards are briefly 

discussed. 

2007 Busse, A. STICKSTOFFLOST-THERAPIE MALIGNER 

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2008 Caby, F. and Tsevrenis, H. TRAITEMENT D'UN 

LYMPHOSARCOMEDU COU PAR L'ASSOCIATION DU 

NITROGÃˆNE-MOUTARDEDE LA RADIOTHERAPIE ET 

DE IA CHIRURGIE. [ASSOCIATION OF NITROGEN 

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2009 

CanÃ²nico, A. N. EL EMPLEO DE LA MOSTAZA NITRO 

GENADA EN EL TRATAMIENTO DEL CANCER AVANZADO; 

EXPERENCIA DEL INSTITUTO DE MEDICINA EXPERI 

MENTAL ANGEL H. ROFFO. [THE USE OF NITROGEN 

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EXPERIENCE OF ANGEL H. ROFFO INSTITUTE OF 

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dr., 1953, 37: 517-524. 

2010 

Â«Cappelini. EFFETS THÃ‰RAPEUTIQUES COMPARATIFS 

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Typewritten. 

2011 

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med., Nap., 1954, 10: 587-596. English 

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2012 

Castex, M. R. and Pavlovsky, A. MOSTAZAS NITRO 

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MIELOIDE CRONICA (COMMUN1CACION PREVIA). 

[NITROGEN 

HODGKIN'S 

MUSTARDS (CHLOROETHYLAMINES) IN 

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B. Aires, 1947, 83-92. 3 refs. tab. 

2013 

Chevallier, P., Lamette, P., Brion, S., and 

Sabouraud. QUELQUES MALADIES DU SANG 

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Index analyt. cancer., Par., 1949, 20: 

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2014 

Craver, L. F. RECENT ADVANCES IN TREATMENT OF 

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20 refs. 

2015 Croizat, P., Papillon, J. and Pinet, F. ROLE 

DE LA MOUTARDE A L'AZOTE DANS LE TRAITEMENT 

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NANT LYMPHOGRANULOMATOSIS.] J. mÃ©a. Lyon, 

1952, 33: 923-926. 4 refs. Report covering 

a 3 year period of therapeutic studies of 

36 patients treated with nitrogen mustard 

only, or with the drug in combination with 

radiotherapy or following radiotherapy. 

Results obtained were generally favorable; 

the combination of radiotherapy and nitro 

gen mustard seemed preferable to the in 

verse combination. 

2016 Dameshek, W. CHEMOTHERAPY OF "LYMPHOMA" AND 

LEUKEMIA. Bull. N. England M. Center, 1949, 

lit 49-62. 15 refs. A review. 

2017 

Dameshek, W., Bloom, M. L., Weisfuse, L., 

Freedman, M. H. and Layrisse. M. CHEMOTHERA 

PY OF LEUKEMIA AND LEUKOSARCOMA; A REPRINT 

OF AN EXHIBIT PRESENTED AT THE AMERICAN MEDICAL 

ASSOCIATION CONVENTION, ATLANTIC CITY, JUNE 

1949. 54 t. NeÂ» York, GruÃ±e & Stratton, 1950. 

2018 Derer., L. 0 PERIODICKEJ UCINNOSTI CHLORALKYL- 

AMINU, RTG OZIARENIA A ACTH PRI LEUKEMII. 

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lek. listy, 1953, 33: 545-553. 12 refs. 

German summary. 

2019 

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1952, 59: 221-224. 9 refs. 

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Ebbe, T. KVAELSTOF-SENNEPSGASBEHANDLING VED 

POLYCYTAEMIA IDIOPATHICA. [NITROGEN MUSTARD 

IN IDIOPATHIC POLYCYTHEMIA.] Ugeskr. laeger, 

1949, 111: 674-675. 

2021 

Egeli, E. S. and ErtÃ¼rkcan, S. POLYCITEMIA 

VERA'DA "NITROGEN MUSTARD" TEDAVISI. [NITRO 

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P. 42.



118 


(Continued) 

2022 

Erslev, A. BEHANDLING AF MALIGNE BLODSYGDOMME- 

OG KRAEFT MED KVAELSTOF-SENNEPSGAS (NITROGEN 

MUSTARD) I Ãœ. S. A.; OVERSIGTSARTIKEL. 

[TREATMENT OF MALIGNANT BLOOD DISEASES AND 

CANCER WITH NITROGEN BUSTARD IN THE Ãœ. S. A.; 

REVIEW]. Ugeskr. laeger, 1948, 110: 167-171 

10 reÃa. 

2023 

Fellinger, K., Braunsteiner, H., Pakesch, F. 

and Reiner, E. E. GLEICHZEITIGE BEHANDLUNG 

MIT NITROGEN MUSTARD UND ACTH BEI NEOPLAS 

TISCHEN ERKRANKUNGEN DES LYMPHATISCHEN SYS 

TEMS. [NITROGEN MUSTARD AND ACTH IN THE 

COMBINED TREATMENT OF NEOPLASTIC DISEASE OF 

THE LYMPHATIC SYSTEM.] Wien, klin. Wschr., 

1951, 63: 572-573. 2 refs. 

2024 

Ferradas, J. B. NUESTRA EXPERIENCIA EN EL TRA 

TAMIENTO DE LA GRANULOMATOSIS MALIGNA. [PER 

SONAL EXPERIENCE WITH TREATMENT OF MALIGNANT 

GRANULOMATOSIS.] 

3Â£: 193-210. 

Arch, argent, tisiol., 1954, 

2025 

Fleischhacker, H. and Klug, H. NITROGEN MUS- 

TARD-BEHANDLUNG VON BLUTKRANKHEITEN UND 

MALIGNEN TUMOREN. [TREATMENT OF BLOOD 

DISEASES AND MALIGNANT TUMORS WITH NITROGEN 

MUSTARD.] Wien. mod. Wschr.. 1949, 99: 

509-511. 21 refs. 

Foit,,R. and Siebcr.oyÃ¡7KlÃmov4,R. KLINICKE 

ZKUSENOSTI S HORCICNYMI DUSIKY. [CLINICAL 

EXPERJENCES WIT NITROGEN MUSTARD.] Cas. 

lek. cesk., 1951, 90: 543-550. 43 refs. 

A review of the use and side-effects of 

nitrogen mustard in cases of lymphogranulomatosis, 

leukemia and erythremia. 

2027 

Foit, R.,and Sieberoya-Klimo vi, R. POUZÃ•VANÃ• 

MIKRODAVEK HORCICNYCH DUSI KO. [ADMINISTRA 

TION OF MICRODOSES OF NITROGEN BUSTARD.] 

Â¿as.lek. cesk., 1952, 91: 382-386. 8 refs. 

ftldvÃ¡ri,t. and NÃ©karo,L. BUSTÃ‚RNITROGÃ‰NNEL 

KEZELT MYCOSIS FUNGOIDES KET ESETE. [TWO 

CASES OF BYCOSIS FUNGOIDES TREATED WITH 

NITROGEN MUSTARD.] Orv. lap., 1948, 4: 

1667-1668. 6 refs. The temporary effect of 

nitrogen mustard in doses of 0.05-0.1 mg/kg 

included reduction in the leucocyte count 

and relief from itching. Remissions occurred 

in a very short time. 

203; 

reidman, R. and Stritzler, C. MYCOSIS FUNGOIDES 

RESISTING TREATMENT WITH BOTH NITROGEN MUSTARD 

AND ANTI-RETICULAR CYTOTIXIC SERUM. J. Invest. 

Derm., 1948, 10: 227. "There was no change in 

the histologicÃ¤l picture following either ni 

trogen mustard or ACS therapy." 

2030 

Garcia Perez, A. and QuiÃ±ones Caravia, P. A. 

UN CASO DE MICOSIS FUNGOIDE TRATADO CON 

MOSTAZA NITROGENADA. [CASE OF MYCOSIS 

FUNGOIDES TREATED 

Actas derm, sif., 

WITH NITROGEN MUSTARD] . 

Madr., 1951, 42: 885-888. 

2031 

Gardikas, C. and Wilkinson, J. F. ALKYLAMINES 

IN THE TREATMENT OF LEUKAEMIA. 

1952, 263: 161-166. 30 refs. 

Lancet, Lond 

Treatment of 

, 

102 paTÃ¯Ã«nts. 

2U32 

Gellhom , A. MANAGEMENT OF THE PATIENT WITH 

HODGKIN'S DISEASE. J. Chronic Dis., 1955, 

U 698-705. 21 refs. A review. 

2033 

Genis Calvez, J. M. and Casalla Chacon, J. M. 

ASPECTO HISTOPATOLOGICO DE LOS GANGLIOS EN 

LA ENFERMEDAD DE HODGKIN TRATADA CON MOSTA 

ZAS NITROGENADAS. [HISTOPATHOLOGICAL AS 

PECT OF GANGLIONS IN HODGKIN'S DISEASE TREATED 

WITH NITROGEN MUSTARD.] Med. 

1953, 21: 652-668. 26 refs. 

col Madr 

Also'in: " 

Medicina, Badr., 1953, 21: 95-109. Report 

of one case history of lymphogranuloma com 

plicated by overall body itching. The 

patient was treated with a total of 25 mg of 

nitrogen mustard, injected intravenously. 

A decrease of lymph nodes.and of lymphocyte 

count, appearance of collagen filament, dis 

appearance of sinuses and an overall improve 

ment of the patient's condition was observed 

17 days following the first injection. 

2034 

Giraud, G. and Cazal, P. LYMPHOSARCOME LEU 

CEMIQUE TRAITÃ‰ PAR L'YPERITE NITRÃ‰E. Ã•LEU- 

KEMIC LYMPHOSARCOMA TREATED WITH NITROGEN 

MUSTARD.] Sang, Par., 1948, 19: 403-408. 

2035 

Granzer, E. VOM GIFTGAS ZUM HEILMITTEL [FROM 

Ã•95?XT 

1953, 8. 

M? SV 

825-828. 

THERAPEUTIC MUG.] Orion, 

A historical review of the 

uses or nitrogen mustard, emphasizing its 

diseases*10 appllcation in malignant blood 

2036 

Haddow, A. THE CHEMOTHERAPY OF CANCER. Practi 

tioner, 1951, 167: 36-47. 132 refs. will be 

supplied upon application to editor. A re 

view. 

2037 

Haddow, A. NOTE ON THE CHEMOTHERAPY OF CANCER 

Brit M. Bull., 1947, 4: 417-425. 109 refs. 

Spanish version in: Recenti progr. med 

1947, 3: 177-201. A review of thÃ¨ use of 

estrogens, 2-chloroethylamines and urethane. 

203,? 

Harkavy, M. B. NEUROBLASTOMA. REPORT OF A 

CASE. 

476* 

Arch. Pediat., N. Y., 1951, 68: 473- 

â€”¿ 

2039 HeÂ£â„¢e11'H- H" TÂ°teT, J. N. and Newman, B. A, 

THE INFLUENCE OF NITROGEN MUSTARD ON MYCOSIS 

FUNGOIDES; OBSERVATIONS RELATING ITS EFFECT 

TO THE RETICULO-ENDOTHEHAL SYSTEM. Blood 

N. Y., 1947, 2: 564-577. 8 refs. Nitrogen 

mustard in doses of 5-6 mg. was intravenously 

administered to six patients with mycosis 

fungoides. Immediate response to the drug 

included remissions which varied with the 

nature of the lesions. Case histories are 

discussed. 

2040 

Ã¯2 â€¢¿ and IIous lrk J, K CHEMOTHER API I 

SYSTÃ‰BOVÃ•CHKREVNÃ•CH ONEMOCNÃ‰NÃ•. [CHEMO 

THERAPY OF SYSTEMIC BLOOD DISEASES.] Pediat 

listy, Praha, 1948, 3: 67-72. 16 refs. 

Ten cases of: lymphogranuloma, chronic leu 

kemia, sympathoblastoma, chloroma of the 

thyroid, tumor of the lung and reticuloendotheliosis 

were treated with nitrogen mustard. 

Good results were obtained in lymphogranu 

loma and chronic leukemia; slight or no 

effects in the remaining diseases. 

2041 

Â«Hochman, A. NITROGEN MUSTARD AND RADIUM THERAPY 

IN HODGKIN'S DISEASE. Harefuah, Tel-Aviv 

1951, 40: 99-101. Abstracted in: Excerpta med 

Sect. 2, 1952, 5: No. 2990. 

2042 

Holub V. LYMFOGRANULOMATOSA MOZKU LÃ‰CENÃ• 

HORCICNYM DUSIKEM. [LYMPHOGRANULOMATOSIS OF 

THE BRAIN TREATED WITH NITROGEN MUSTARD.] 

Lek. listy, Brno, 1949, 4: 222-226. A 28 

year old female patient with lymphogranulomatosis 

of the extrapyramidal system was 

first treated with X-rays. When radio 

therapy failed, injections of nitrogen 

mustard totaling 34 mg were administered 

and a symptomless period lasting two months 

ensued.



119 


(Continued) 

2043 Huguenin, R., Hebrard and Saracino,,R. DIS 

PARITION D'UN VASTE EPITHELIOMA-DEVELOPPE 

SUR RADIODERMITE-SOUS L'INFLUENCE DE LA 

CHIMIOTHERAPIE. [DISAPPEARANCE AFTER CHEMO 

THERAPY OF A LARGE EPITHEHOMA DEVELOPED ON 

A RADIODERMITIS.] Bull. Ass. fr, cancer, 

1950, 37: 168-175. "Addendum," p. 327. 

AbstracTed in: Excerpta med., Sect. 5, 1952, 

5: No. 50. 

2 Jores, A. and Goldeck, H. KLINISCHE ERFAHRUNGEN 

MIT DER STICKSTOFF-LOST-THERAPIE. [CLINICAL 

RESULTS WITH NITROGEN MUSTARD THERAPY.] Ther. 

Gegenwart, 1949, 86-90. 13 refs. 

2045 

Karnofsky, D. A. THE MANAGEMENT OF LEUKEMIA 

IN ADULTS. 

3225-3228. 

N. York 

9 refs. 

State J. M., 

A review. 

1954, 54: 

2046 

Keibl, E. UEBER KOMBINIERTE N-LOST-URETHAN- 

THERAPIE CHRONISCHER MYELOSEN. [COMBINED 

NITROGEN MUSTARD AND URETHANE TREATMENT OF 

CHRONIC MYELOSIS.] 

1955, 67;: 356-361. 

Wien. klin. 

29 refs. 

Wschr., 

2047 

Khazanov, A. I. OPYT LECHEBNOGO PRIMENENIIA 

DUAMINA. [THERAPEUTIC APPLICATION OF DUAMIN.] 

Klin, med., Moskva, 1951, 29: No. 2, 79-82. 

Duamin in doses of 0.1 mg was administered 

to 21 patients with Hodgkin's disease and 

lymph node tumors. The blood picture returned 

to normal, the size of the spleen decreased, 

but severe agranulocytosis and panmyelophthisis 

occurred. 

2048 

Kupfer, C. RETINOBLASTOMA TREATED WITH INTRA 

VENOUS NITROGEN MUSTARD. 

36: 1721-1723. Abstracted 

Am. J. Ophth., 1953, 


Sect. 16, 1954, 2: No. 3140. 

2049 L., C. EL TRATAMIENTO DE CIERTOS NEOPLASMAS 

POR LOS COMPUESTOS AZOADOS DEL GAS MOSTAZA. 

[TREATMENT OF SOME NEOPLASMS WITH NITROGEN 

MUSTARD COMPOUNDS.] 

1948, 20: 971-972. 

DÃ•a mÃ©d., B. Air., 

Landolt, R. F. BEITRÃ„GE ZUR NITROGEN-MUSTARD- 

THERAPIE. [NITROGEN MUSTARD THERAPY.] Ann. 

paediat., Basel, 1950, 174: 28-29. 

2051 Landsheere, B. de and Otte, P. NITROGEN MUSTARDS; 

BEHANDELING VAN ZIEKTE VAN HODGKIN EN AANVERWANTE 

AANDOENINGEN, [NITROGEN MUSTARDS; TREATMENT OF 

IIODGKIN'S DISEASE AND RELATED DISEASES.] Belg. 

tschr. geneesk., 1948, 4: 886-897. tab. 10 refs. 

2052 

Leibetseder, F. and RabÃ, I. 

N-LOST (NITROGEN MUSTARD). 

ERFAHRUNGEN 

[EXPERIENCE 

MIT 

WITH 

NITROGEN MUSTARD.] Klin. Med., Wien, 1951, 

6: 521-526. 14 refs. A report on three 

years experience with nitrogen mustard. Good 

therapeutic results were obtained in Hodgkin's 

disease treated with total doses of 1 mg per 

kg of weight; cases refractory to radiotherapy 

were rendered sensitive by nitrogen mustard. 

One case of agranulocytosis occurred. Good 

results were obtained in a case of lymphoblastoma 

and 3 cases of polycythemia vera but 

none in sarcoma of various kinds. The reaction 

of the white cells afforded an index of the 

degree of success to be expected. Method of 

administration of the drug to effect greatest 

amount of tolerance is discussed. 

2053 

Leucutia, T. NITROGEN MUSTARD 

Roentg., 1949, 6U 104-107. 

THERAPY. 

10 refs. 

Am. 

A 

J. 

review. 

2054 

Â»Levin, W. C. and Holt, J. G. NITROGEN MUSTARD 

IN TREATMENT OF LEUKEMIAS. Texas J. M., 

1949, 45: 551-557. 

2055 

Lindemann, M. and Gummel , H. LOSTTHKRAPIE BEI 

BÃ–SARTIGEN GESCHWÃœLSTEN. [NITROGEN MUSTARD 

THERAPY OF MALIGNANT TUMORS.] Deut. Gesundhwes., 

1950, 5: 1506-1516. 79 refs. 

2056 

Lukl.^P. PROGNOSA LYMFOGRANULOMU LÃ‰CENEHO CHLORO- 

VANYM ALKULAMINEM. [PROGNOSIS OF HODGKIN'S 

DISEASE TREATED WITH NITROGEN MUSTARD.] Cas. 

lek. ceskâ€ž,1949, 1134-1141. tab. 3 refs. 

English summary. "Hodgkin's disease in 23 

patients was treated with nitrogen mustard 

in doses of 5-6 mg. Complete relief of symp 

toms occurred in 27.3%, partial remission in 

48.5% and no recovery in 24.7%. The average 

duration of remission was 3.8 months. De 

pression of bone-marrow function occurred as 

a complication in 6 patients, 4 of them were 

over 40 years of age . 

2057 

Lynch, J. p., Ware, P. F. and Gaensler, E. A. 

NITROGEN MUSTARD IN THE TREATMENT OF INOPER 

ABLE BRONCHIOGENIC CARCINOMA. Surgery, 

27: 368-385. 36 refs. A report of the 

1950 

use 

Ã–T nitrogen mustard in the treatment of 69 

patients, of which 69% experienced moderate 

\o excellent temporary subjective relief. 

The treatment seems to have a definite place 

in palliative treatment of bronchiogenic 

tumors. 

2058 McHugh, J. M. and Ziehl, F. L. NITROGEN MUSTARD 

IN NEOPLASTIC DISEASES . PART II. Marquette 

M. Rev., 1948, 13^: 100-108. 27 refs. The 

status of nitrogen mustard is evaluated by 

reviewing all the treated cases (438) reported 

in the literature. 

2059 

Â«Martinez, I. G., Malaret, P. S., Taveras, J., 

Hazim, H. and Olivencia, L. REVISION OF THE 

CLINICAL INVESTIGATION OF THE EFFECTS OF 

NITROGEN MUSTARD ON BLASTOMAS OF THE RETI- 

CULOENDOTHEHAL SYSTEM. Rev. Liga puertorriq. 

cancer, 1951, 11: No. 2, 3-41. Abstracted 

in: Leukemia ABstr., 1953, 1_:No. 366. 

2060 

Merk, R. ERFAHRUNGEN MIT DER STICKSTOFFLOST- 

BEHANDLUNG. (EXPERIENCES WITH NITROGEN MUS 

TARD THERAPY.] Verb. Deut. Ges. inn. Med. 

1949, 55: 395-398. 

2061 

Merck, R. DIE STICKSTOFFSENFGASBEHANDLUNG DER 

LYMPHOGRANULOMATOSE . [NITROGEN MUSTARD GAS 

TREATMENT OF LYMPHOGRANULOMATOSIS .] Med. 

Klin., Beri., 1948, 43: 629-633. 7 refs. 

J-*â€¢â€¢ "â€¢ Ass" 

2062 Meyer, O. O. TREATMENT OF HODGKIN'S DISEASE 

2063 

Nabarro, J. D. N. DISCUSSION OF THE CHEMOTHERAPY 

OF THE RETICULOSES. Proc. R. Soc . M., Lond.. 


Leukemia" Abstr., 1954, 2: No. 480. 

2064 

Â»Newman, B. A. MYCOSIS FUNGOIDES WITH VERTEBRAL 

INVOLVEMENT TREATED WITH NITROGEN MUSTARD. 

A.M. A. Arch. Derm., 1949, 60: 1215-1217. 

2065 

Paulino, W. CHEMIOTERAPIA DEI TUMORI. I. 

IPRITE E DERIVATI AZOIPRITICI; RASSEGNA 

SINTETICA. [CHEMOTHERAPY OF TUMORS. I. 

MUSTARD GAS AND NITROGEN MUSTARD DERIVATIVES; 

SYNTHETIC REVIEW.] Minerva med., Tor., 1953 

44: 39-51. 184 refs.



120 


(Continued) 

2066 Pedro-Botet, J. LA TERAPÃÛTICA CON LAS MOSTAZAS 

NITROGENADAS (M. N.). [NITROGEN MUSTARD THERA 

PY.] Med. clin., Barcelona, 1949, 12: 363-373. 

13 rets. 

2067 Piemonte, [M] L'ACTION DES RAYONS X ET DE 

L'YPE'RITE AZOTÃ‰E DANS LE TRAITEMENT DE LA 

MALADIE DE HODGKIN. [EFFECT OF X-RAYS AND 

NITROGEN MUSTARD IN THE THERAPY OF HODGKIN'S 

DISEASE ] J. mod. Lyon, 1952, 33: 917-922. 

Also in: J. radio, electr., 1953~7 34: 80- 

82. 

2068 Polli, E. and Magnini, A. AZIONE BIOLOGICA 

ED APPLICAZIONI TERAPEUTICHE DELLE AZOIPRITI. 

[BIOLOGICAL ACTION AND THERAPEUTIC APPLICA 

TIONS OF THE NITROGEN MUSTARDS.] Omnia ther., 

Pisa, 1952, 3: 351-400. 

2069 

Raphael, M. and Reilly, C. N. THE USE OF NITRO 

GEN MUSTARD IN ADVANCED BRONCHOGENIC CARCINOMA. 

Dis. Chest., 1954. 25: 215-220. 6 refs. 

Bronchogenic carcinoma in 56 patients was 

treated with daily intravenous doses of 0.1 mg 

nitrogen mustard. Good results were achieved 

in 46.5% of the cases. The drug is particularly 

valuable where superior vena cava obstruction 

must be relieved rapidly. 

2070 

Rattigan, J. P., Michelson, A. L. and Pomerantz, 

A. Z. BRONCHOGENIC CARCINOMA WITH INTRA- 

CRANIAL METASTASIS (SYMPTOMATIC IMPROVEMENT â€¢¿ 

FOLLOWING NITROGEN MUSTARD 

1952, 3: 25-27. 5 refs. 

THERAPY). BMQ, 

2071 

REPORT FROM THE AUSTIN HOSPITAL ON THE USE OF 

NITROGEN MUSTARD. 

2: 888-890. 

Med. J. Australia, 1951, 

2072 

Rollins, E. and Shaw, C. C. ACTH AND NITROGEN 

MUSTARD IN THE TREATMENT OF NEOPLASTIC DISEASES. 

U. S. Armed Forces H. J., 1955, 6: 1434-1442. 

13 refs. 

2O73 

Rosenthal, E. NITROGEN-MUSTARD THERAPY COMBINED 

WITH SPLENECTOMY. Lancet, Lond., 1948, 1: 

408. 

2074 

Salamone, L. and Sanfilippo, S. SU UN CASO DI 

MIELOSI ERITREMICA SUBACUTA TRATTATO CON AZO- 

IPRITE. 

MYELOSIS 

[A CASE 

TREATED 

OF SUBACUTE ERYTHRAEMIC 

WITH NITROGEN-MUSTARD.] 

Riforma med., 1953, 67: 1160-1165. 39 refs. 

English summary. Treatment with vitamin B}2 

caused disappearance of the megaloblasts 

which had been circulating in the blood and 

nitrogen mustard brought about a remission in 

the clinical-hematological picture. 

2075 Schatter, K. BEITRAG ZUR STICKSTOFF-LOST- 

THERAPIE BEI DER POLYCYTHAEMIA VERA. [NITROGEN 

MUSTARD IN THE TREATMENT OF POLYCYTHEMIA VERA.] 

Ther. Gegenw., 1952, 9^: 23-24. Administration 

of 32.5 mg nitrogen mÃ¼Ttard led to remission 

observed for 9 months. 

2076 Schulze, W. and Brauner, H. BEITRAG ZUR STICK 

STOFF -LOST -BEHANDLUNG VON HAUTTUMOREN. [NI 

TROGEN MUSTARD THERAPY OF SKIN TUMORS.] 

Arch. Derm. Syph., Beri., 1951, 192: 144-163. 

28 refs. 

2Â°Segovia de Arana, J. M. APLICACIONES TERAPÃ‰UTICAS 

DE LAS MOSTAZAS NITROGENADAS. [THERAPEUTIC AP 

PLICATIONS OF THE NITROGEN MUSTARDS.] Rev. 

clin, espaÃ±., 1949, 33: 291-297. 18 refs. 

A review. 

2078 

Sievers, K. and Harwerth, H. G. ZUR THERAPIE 

SYMPTOMATISCHER HÃ„MOLYTISCHER ANÃ„MIEN. 

[THE TREATMENT OF SYMPTOMATIC HEMOLYTIC 

ANAEMIA.] Acta haemat.. Basel, 1953 9- 

208-220. 

2079 _ , 

Soyka, O. and Fibigerova, L. PREDBEZNA ZPRAVA 

0 THERAPII PREPARATEM TS 160 PRI TUBERKULOSE 

PUC A MÃ•ZNÃ•CHUZLIN. [PRELIMINARY REPORT 

ON THE NITROGEN MUSTARD THERAPY OF PULMONARY 

TUBERCULOSIS AND LYMPHATIC NODES.] Cas. lek. 

fiesk., 1951. 90: 637-641. 17 refs. Nitrogen 

mustard in doses of 0.01 mg 4 times weekly 

over a period of three weeks administered to 

patients with sarcomatous tumors improved 

their overall condition but did not affect 

their blood picture. 

2080 

Storti, E. RICERCHE CLINICHE E SPERIMENTALI 

SULLA MOSTARDA AZOTATA. [CLINICAL AND EX 

PERIMENTAL RESEARCH ON NITROGEN MUSTARD.] 

Minerva raed., Tor., 1949, 40: pt. 2, 323- 

324. French translation InT Sang, Par., 

1950, 21: 340-345. 

2081 Talbott, J. H. CLINICAL MANIFESTATIONS OF 

HODGKIN'S DISEASE. N. York State J. M., 

1947, 47: 1883-1888. 8 refs. No greater 

benefits' were observed from treatment with 

nitrogen mustard than from treatment with 

radiation. 

2082 

Â«Tazaki, Y., Fuchigami, A. and Oota, K. PRECI 

PITOUS LEUCOPENIA IN A N-MUSTARD TREATED 

LEUKEMIA; 

1951, 42: 

(AN AUTOPSY 

302-307. 

CASE). Gann, Tokyo, 

20{. eyschl, O. SYMPATHOGONIOMA. 

1949, 4: 49-56. 9 refs. 

Pediat. 

Listy, 

2084 

Tipton, G., Schneider, M., Poth, E. J. and 

Levin, W. C. NITROGEN MUSTARD IN THE TREAT 

MENT OF HODGKIN'S DISEASE; A CASE REPORT WITH 

DISCUSSION. Texas Rep. Biol. M., 1948, 6: 

117-122. 

2085 

TRATAMIENTO DE LA ENFERMEDAD DE HODGKIN POR EL 

GAS DE MOSTAZA. [TREATMENT OF HODGKIN'S 

DISEASE WITH MUSTARD GAS.] Dia mÃ©d., B. Air 

1952, 24: 537-539. 

Trnovsky, I. HOftÃ’lCNYDUSÃ•K V LEÃ•BE SYSTÃ‰MO- 

VYCH ONEMOCNÃˆNI. [NITROGEN MUSTARD IN THE 

TREATMENT OF SYSTEMIC DISEASES.] Lek. listy, 

Brno, 1949, 4: 615-620. 6 refs. 

2087 

Ultzmann, H. STICKSTOFFLOSTTHERAPIE IN DER 

UROLOGIE. 

Krebsarzt, 

[NITROGEN MUSTARD IN UROLOGY.] 

Wien, 1952, 7: 135-140. 

2088 

Urteaga BailÃ³n, O. TRATAMIENTO DE LOS LEUCEMIAS 

CON ALKILAMINAS. [TREATMENT OF LEUKEMIAS 

WITH ALKYLAMINES.] 162 p. Lima, Peru, 

Editora Medica Peruana, 

Med. Hosp. "2 de Mayo") 

1947. (Thesis-Fac. 

56 pi. 2 tab. 

17 refs. 

2Â°Valdivieso Conde, L. and Morandeira Vaamonde, L. 

HODGKIN PULMONAR; TRATAMIENTO Y EVOLUCIÃ“N CON 

MOSTAZAS NITROGENADAS. [PULMONARY HODGKIN'S 

DISEASE; TREATMENT AND EVOLUTION WITH NITRO 

GEN MUSTARDS.] Rev. clin, espaÃ±., 1953, 49: 

247-252. 10 refs. One case of lymph&granulomatosis 

unsuccessfully treated with nitro 

gen mustard is reported.



121 

NITROGEN MUSTARDS â€”¿ THERAPY (Continued) 

2090 Vasterllng, H. W. DIE BEHANDLUNG MIT STICKSTOFF- 

LOST UND IHRE EXPERIMENTELLENGRUNDLAGEN. 

[NITROGEN MUSTARDTHERAPYAND ITS EXPERIMENTAL 

BASES.] Strahlentherapie, 1953, 92: 48-60. 


2091 Viacava, E. TRATAMIENTO DEL CANCER DE CUELLO 

UTERINO AVANZADO CON MOSTAZA NITROGENADA. 

[TREATMENT OF ADVANCED CANCER OF THE UTERINE 

CERVIX WITH NITROGEN MUSTARD.] Bol. Acad. 

argent, cir., 1953, 37: 401-402. 

Viacava, E. P., Schavelzon, J. and Mayo, J. 

GAS DE MOSTAZA INTRA ARTERIAL. [INTRAARTERIAL 

MUSTARD GAS.] Bol. Acad. argent, cir., 1953, 

37; 564â€”574. 

2093 

Videbaek, A. OM BRUCEN AF N-SENNEPSGAS. [ON 

THE USE OF 

1949, 111: 

NITROGEN 

147-148. 

MUSTARD.] Ugesk 


laeger 

Dis- ' 

cussion based on treatment of 22 patients. 

The toxic effects of nitrogen mustard are 

stressed. 

2094 Wintrobe, M. M.,, McLennan, M. T. and Huguley, 

C. M., Jr. CLINICAL EXPERIENCES WITH NITRO 

GEN MUSTARD THERAPY. In: APPROACHES TO 

TUMOR CHEMOTHERAPY. Wash., Am. 

Sc., 1947, p. 347-357. 2 refs. 

Ass. Advance. 

2095 

Â«Zinov'eva, V. N. OPYT KHIMIOTERAPII LIMFO- 

GRANULOMATOZA. [CHEMOTHERAPY OF LYMPHO- 

GRANULOMATOSIS.] Shorn, nauch. tr. 

KrasnofÃ rsk. gosud. med. inst., 1953, No. 

3, 169-172. Abstracted in: Ref. zh. Biol., 

1955, No. 2146. Duamin, a nitrogen mus 

tard analog, in doses of 1 mg/10 kg was ad 

ministered intravenously to 13 patients 

with various lymphogranulomatoses. To 

reduce the toxic effects of duamin, one 

half hour before the admlnisteration of 

duamin, 1 ml of a 110% caffein solution 

was administered. Following the second 

duamin injection the general condition of 

the patients improved, the swelling of the 

lymph nodes decreased and the tumor mass 

in the mediastinum and peritoneal cavity 

regressed. Remissions lasted 2-5 months. 

Leukopenia is most frequently a toxic side 

effect of duamin, but chlorhydrate, luminal 

and amital natrium effectively reduce this 

toxicity. Four patients died. 

See 

134 

498 

591 

1084 

2386 

TOXICITY 

181 

525 

595 

1085 

2506 

232 

548 

614 

1909 

3257 

457 

551 

693 

1562 

3390 

461 

566 

858 

1576 

3424 

2096 

Anslow, W. P., Jr., Karnovsky, D. A., Jager, 

B. V. and Smith, H. W. THE TOXICITY AND 

PHARMACOLOGICAL ACTION OF THE NITROGEN MUS 

TARDS AND CERTAIN RELATED COMPOUNDS. 

J. Pharm. Exp. Ther., 1947, 91: 224-235. 

10 refs. 

2097 

Boyland, E. THE TOXICITY OF ALKYL BIS(>3 -CHLORO- 

ETHYDAMINES AND OF THE PRODUCTS OF THEIR REAC 

TION WITH WATER. Brit. J. Pharm., 1946, 1 : 

247-254. 4 refs. Abstracted in: Chem. ABstr., 

1947, 41: No. 21651. 

2098 

Di Porto, A. and Bartoli, L. MODIFICAZIONI 

ISTOLOGICHE NELLA INTOSSICAZIONE E NELLA 

CURA CON SOSTANZE A TIPO AZOTO-IPRITE. 

[HISTOLOGIC MODIFICATIONS DUE TO INTOXI 

CATING AND THERAPEUTIC DOSES OF NITROGEN 

MUSTARDS.] Policlinico, sez. med. 1951 

58: 51-64. 24 refs. 

2099 

Friemann, W. LOSTSCHADEN AM AUGE. [EYE LESIONS 

DUE TO NITROGEN MUSTARD.] Ber. Deut, ophth. 

Ges., (1949), 1950, 55: Â¿30-334. 

2100 

Goldeck, H. TOXISCHE BELGLEITWIRKUNGEN DER 

STICKSTOFF-LOST- THERAPIE . [TOXIC SECONDARY 

EFFECTS OF NITROGEN MUSTARD THERAPY] Sang, 

Par., 1950, 2\: 390-394. 

2101 

Goldin, A., Noe, H. A., Landing, B. H., Shapiro, 

D. M. and Goldberg, B. A NEUROLOGIC SYNDROME 

INDUCED BY ADMINISTRATION OF SOME CHLORINATED 

TERTIARY AMINES. J. Pharm. Exp. Ther., 1948, 

94: 249-261. 13 refs. "The compounds which 

produced the waltzing syndrome were dialkyl 

and heterocyclic-beta-chloroethylamines. .. 

Primary and secondary beta-chloroethylamines ; 

related quarternary compounds; and bis, tris, 

and tetrakis beta-chloroethylamines did not 

elicit the effect." 

2102 

Graef, I., Karnofsky, D. A., Jager, V. B., 

Krichesky, B. and Smith, H. W. THE CLINICAL 

AND PATHOLOGIC EFFECTS OF THE NITROGEN AND 

SULFUR MUSTARDS IN LABORATORY ANIMALS. Am 

J. Path., 1948, 24: 1-47. 4 pi. 64 refs. 

2103 

Landing, B. H. and Eisenberg, F. F. NITROGEN 

MUSTARDS. STATISTICAL ANALYSIS OF EFFECTS 

ON SARCOMA 180 AND VISCERA OF NORMAL MICE 

IN RELATION TO TOXICITY AND STRUCTURE . 


2104 

Landing, B. H., Goldin, A., Noe, H. A., Goldberg. 

B. and Shapiro, D. M. SYSTEMIC PATHOLOGICAL 

EFFECTS OF NITROGEN MUSTARDS, AND A COMPARISON 

OF TOXICITY, CHEMICAL STRUCTURE AND CYTOTOXIC 

EFFECT, WITH REFERENCE TO THE CHEMOTHERAPY OF 

TUMORS. Cancer, N. Y., 1949, 2: 1055-1066 

13 refs. 

2105 

Landing, B. H., Goldin, A., Noe, H. A., Taylor, 

J. B., Fugmann, R. A., Goldberg, B. and Fisk! 

A. J. TESTICULAR LESIONS IN MICE FOLLOWING 

PARENTERAL ADMINISTRATION OF NITROGEN MUS 

TARDS. Cancer, N. Y., 1949, 2: 1075-1082 

17 refs. 

8108 

Schleicher, I. ERFAHRUNGEN BEI DER BEHANDLUNG 

MIT STICKSTOFFLOST. [EXPERIENCES WITH NITRO- 

2107 

Weston, J. T. EPITHELIAL ATYPIAS WITH CHEMO 

THERAPY IN 100 ACUTE CHILDHOOD LEUKEMIAS 

Cancer, Phila., 1955, .8: 179-186. 18 refs 

See 

1904 TOXICITY, 1945COUNTERACTION 1998 2121 TO 3467 

2108 

Betz, H. and Closon, J. ACTION PROTECTRICE DU 

NACN SUR L'EFFET LETHAL L'UNE YPERITE X L'AZOTE. 

[PROTECTIVE ACTION OF NACN AGAINST THE LETHAL 

EFFECT OF NITROGEN MUSTARD.] C. rend. Soc. 

biol., 1952, 146: 1426-1429. 10 refs. 


7: No. 531.



122 

NITROGEN MUSTARDS â€”¿ TOXICITY, COUNTERACTION 

TO (Continued) 

2109 

Brandt, E. L. and Griffin, A. C. REDUCTIONOF 

TOXICITY OF NITROGENMUSTARDSBY CYSTEINE. 



5: No. 3149; Chem. Abstr., 1952, 46: No. 646e. 

2110 

Domokos, J. and Kelemen, E. KLINIKAI ES 

Ã•LLATKISERLETEK MUSTARNITROGEN OKOZTA 

HANYÃ„S ILL. CSONTVELÃ–KAROSODAS KIVEDESERE 

PYRIDOXINNAL ILL. CHOLINNAL. [CLINICAL 

AND EXPERIMENTAL STUDIES ON THE PROPHY 

LACTIC EFFECT OF PYRIDOXIN, I.E. CHOLINE 

ON NAUSEA AND BONE MARROW DAMAGE CAUSED 

BY NITROGEN MUSTARD.] Orv. hetil., 1950, 

91: No. 23, 712-714. 22 refs. Hodgkinis 

dTsease in 12 patients was treated with 

nitrogen mustard. To counteract the 

nausea effect of the drug, injections of 

Wandervit B6 pyridoxine were administered. 

The nausea was checked without otherwise 

influencing the beneficial effects of 

nitrogen mustard. In 49 mice and 11 dogs 

previously treated with nitrogen mustard, 

choline neither checked nausea nor had 

prophylactic effects upon the bone marrow 

of the animals. 

2111 

Fleischhacker, 

CYTOSTATISCHE 

H. DIE 

MITTEL 

BEEINFLUSSUNG DER DURCH 

BEDINGTEN GRANULOCYTO- 

PENIEN MIT CHOLIN, PYRIDOXIN, ETC. [THE 

INFLUENCE OF CHOLINE, PYRIDOXINE, ETC. ON 

GRANULOCYTOPENIA CAUSED BY CYTOSTATIC AGENTS.) 

Sang, Par., 1950, 21: 368-372. Good results. 

2112 Foit, R. and SieberovÃ¡-KlimovÃ¡, R. VLIV PYRI- 

DOXINU NA TOXICKE PRÃ•ZNAKY PO CHLORETHYL- 

AMINECH. [EFFECT OF PYRIDOXJNE ON,THEVTOXI- 

CITY OF CHLORETHYLAMINES.] Cas. lek. cesk., 

1951, 90: 1232-1235. l pi. 19 refs. 

PyridoxTntused in conjunction with nitrogen 

mustard, immediately following the nitrogen 

mustard injections, lessens the latter's 

toxicity. This was tested on two patients 

with Grawitz tumor and lymphogranulomatosis. 

2113 

Schindel, L. OBSERVATIONS WITH NITROGEN MUS 

TARDS. Acta med. orient., Jerusalem, 1949, 

8: 137-144. 8 refs. 

1983 

NITROGEN MUSTARDS. ALANDJE, (N-DI-(2-CHLORO- 

ETHYL)AMINOPHENYL- 

2114 

Larionov, L. F., Khokhlov, A. S., Shkodinskaia, 

E. N., Vasina, 0. S., Trusheikina, V. I. and 

Novikovi, M. A. O PROTIVOOPUKHOLEVOI AKTIV- 

NOSTI N-DI-(2-KHLORETIL) AMINOFENILALANINA 

(SARKOLIZINA). [THE ANTI-TUMOR EFFECT OF 

N-DI-(2-CHLORETHYL) AMINOPHENYLALANINE (SAR 

COLYSINE).] Biul. eksp. biol. med., 1955, 39: 

No. 1, 48-52. 12 refs. The drug was tested" 

against transplanted sarcoma 45 in 240 rats. 

Injections of 0.5-1 g sarcolysine, given at 

intervals of 72 hrs, seven days following 

transplantation resulted in complete tumor 

regression accompanied by only slight toxic 

side effects. Sarcolysine caused only partial 

regression of growth in the spindle cell 

sarcoma of the U strain rat and in the carcino 

ma in the milk gland of the RSM strain of 

mice. Effects of sarcolysine on the blood 

and bone marrow are similar to those of nitro 

gen mustard, but to achieve such effects the 

dosage of sarcolysine must be five times that 

of nitrogen mustard. 

2115 Larionov, L. f., Shkodinskaia, E. N., Troosheikina, 

V. I., Khokhlov, A. S., Vas ina, O. S. 

and Novikova, M. A. STUDIES ON THE ANTI- 

TUMOR ACTIVITY OF P-DI-(2-CHLOROETHYL)AMINO 

PHENYLALANINE (SARCOLYSINE). Lancet, Lond., 

1955, 2: 169-171. 12 refs. 

2116 

NOVYI PROTIVOOPUKHOLEVOI PREPARAT SARKOLIZIN. 

[A NEW ANTITUMOR PREPARATION, SARKOLYSINE.1 

Vest. 

82-83. 

Akad. 

Good 

med. 

results 

nauk 

were 

SSSR, 

obtained~when 

1956, 11: No. 1, 

sarkolysine was administered to 75 patients 

with seminoma, reticulosarcoma, angioendotholloma 

and Jung sarcoma. 

2116a 

Zhdanov, G^L. DEISTVIE SARKOLIZINA NA PRO- 

LIFERIRUIUSHIE TKANI. [THE EFFECT OF SARCO 

LYSINE ON PROLIFERATING 

onkol., 1955, 1: No. 6, 

TISSUE.] Vopr. 

94-98. 9 refs. 

Sarcolysine is most effective among the 

chloroethylamines when administered to rats 

with sarcoma 45. 

NITROGEN MUSTARDS. ALANINES. 

2117 

Â«Onta, K., Saito, T., Tsuneyoshi, H., Suzuki, H. 

and Kimura, K. USE OF TEM AND ALANINE NITRO 

GEN MUSTARD IN THE TREATMENT OF LEUKEMIA. 

Acta haemat. jap., 1954, 17: 119. In Japanese. 

Abstracted in: Leukemia Aostr., 1954, 2: No. 

998. 

NITROGEN MUSTARDS. ANILINE, p-AMINO-N-N- 

DI (CHLOROETHYL)- 

2118 Rinaldini, L. M. THE ANTIMITOTIC ACTION OF AN 

AROMATIC NITROGEN MUSTARD ON TISSUE CULTURES. 

Brit. J. Cancer, 1952, 6: 186-196. 1 pi. 

22 refs. "In every experiment a marked de 

crease of dividing cells was observed. High 

concentrations kill the cultures and produce 

gross cytological abnormalities in both 

dividing and resting cells. With dilute 

solutions a large proportion of cells are pre 

vented from entering mitosis, but no pycnosis 

or vacuolation appears. This effect is 

exerted mainly during interpbase. Pro- and 

metaphase abnormalities are conspicuous and 

ana- and telophase abnormalities rare during 

the first 24 hours, anaphase abnormalities 

increasing after this period." 

NITROGEN MUSTARDS. BUTYRIC ACID, N, N-DI-2- 

CHLOROETHYL-p- AMINO- PHENYL- 

2119 Bollag, W. TIEREXPERIMENTELLE UNTERSUCHUNGEN 

ÃœBER DIE WIRKUNG EINIGER CYTOSTATICA AUF DAS 

BLUTBILD. [EXPERIMENTAL STUDIES OF THE 

EFFECTS OF SOME CYTOSTATIC AGENTS ON THE 

BLOOD PICTURE.] Schweiz, med. Wschr., 1953, 



See 

3454



123 

NITROGEN MUSTARDS. ETHANOL HYDROCHLORIDE 

2-BIS(/3-CHLOROETHYLAMINO- 

2120 

Beretta, G. il., Morelli, E. and Sant'Elia, F. 

MODIFICAZIONI MORPHOLOGIQUE PROVOCATE DA 

UN DERIVATO D'IDROLISI DELL'AZOTOYPRITE: 

IL CLORIDRATO DI lÃ¬,/V -DICLOROETIL- |Â»ti - 

ETANOLAMINA(CONTARDI)SU TESSUTI PATOLOGICI 

DELL'UOMO E DEGLI ANIMALI. [MORPHOLOGIC 

MODIFICATIONS CAUSED BY HYDROLYTIC DERIVA 

TIVE OF NITROGEN MUSTARD: HYDROCHLORIDE ÃŸft 

' -DICHLOROETHYL- ft ' ' -ETHANOL AMINE(CON- 

TARDI) ON THE PATHOLOGICAL TISSUE CULTURES 

IN 

38: 

MAN AND ANIMALS.] 

161-175. 5 reÃs. 


Experiments on 

1952, 

Walker 

carcinoma, reticulosarcoma, Hodgkin's disease, 

leukemia and lymphosarcoma tissue cultures 

showed that this nitrogen mustard derivative 

was less toxic and more selective mitotically 

than other dÃ©rivÃ¢tes used currently. 

NITROGEN MUSTARDS. ETHYLAMINE, BENZYL-DIifl- 

CHLORO- 

2121 

Kravchenko, A. I. ALKOKSI-PROIZVODNYEBENZIL- 

DI((J -KHLORETIDAMINA V EKSPERIMENTAL'NOI 

KHIMIOTERAPII OPUKHOLEI. [ALKOXY-DERIVATIVE 

BENZYL-DIG? -CHLOROETHYDAMINEIN EXPERIMENTAL 

CANCERCHEMOTHERAPY.] 

No. 6, 84-94. tab. 8 reis. 

Vopr. 

All 

onkol., 

the tested" 

1955, 1: 

compounds were less toxic than embikhin. The 

least toxic was the Po isomer. All the com 

pounds effectively inhibited the growth of 

sarcoma 45 in rats. 

NITROGEN MUSTARDS. ETHYLAMINE, DIETHYL-/3-IODO- 

2122 

Seligman, A. M., Rutenburg, A. M. and Friedman, 

O. M. DISTRIBUTION STUDIES IN MICE FOLLOWING 

THE INTRAVENOUS INJECTION OF DIETHYL-P -IODO- 

ETHYLAMINE HYDROCHLORIDE PREPARED WITH RADIO 

ACTIVE IODINE. J. Nat. 

9: 261-270. Abstracted 

Cancer Inst., 1949, 

in: Chem. Abstr., 

T949, 43: 8059e. Most of the mustard was 

rapidly changed and reached the tissues in 

the form of the ammonium ion, but a small 

portion reached the tissues intact and pene 

trated the cells. The highest concentration 

of radioactivity due to IÃ•31NM was noted in 

blood, lung, and lymph nodes. Lower con 

centration of radioactivity was noted in 

kidney, liver and sarcoma 37 growing in the 

subcutaneous space. Diethyl-/) -iodoethylamine 

was about l/30th as 

bis(J3 -chloroethyDamine. 

toxic as methyl- 

NITROGEN MUSTARDS. ETHYLAMINE, ETHYL BIS- 

(/3-CHLORO- 

2123 Justin-Besancon, L., Lamotte-Barillon, S. and 

Polonovski, C. PREMIERS RÃ‰SULTATS DE RECHERCHES 

BIOLOGIQUES EFFECTUÃ‰ESAU COURS DE L'Ã‰TUDETHERA 

PEUTIQUE DES ANALOGUESDE L'YPERITE. [PRELIMI 

NARYRESULTS OF BIOLOGIC RESEARCHDURING THERA 

PEUTIC STUDYOF NITROGENANALOGUES.] Sem. hop. 

Paris, 1948, 24: 1529-1532. Report on the 

action of metEyl-bis- Achloroethylamlne and 

ethyl-bis-^-chloroethylamine and a bromine 

derivative of the former in a variety of ex 

periments on bacteria, animals and men. The 

reduction of toxicity of the compounds by the 

use of hexa-methylene-tetramine was tested. 

Compare with Justin-BesanÃ§on, L. and others. 

Bull. Soc. mÃ©d.hop. Paris, 1948, 64: 582-586. 

NITROGEN MUSTARDS. ETHYLAMINE, ISOPROPYL BIS- 

O-CHLORO- 

See 

1953 

NITROGEN MUSTARDS. ETHYLAMINE, METHYL BIS- 

(/3-BROMO- 

2124 

Justin-BesanÃ§on, L., Lamotte-Barillon, S., 

Polonovskv, C. and Bestaux, RECHERCHES SUR 

DES DÃ‰RIVES AZOTES DE L'YPERITE DANS LE 

TRAITEMENT DE LA MALADIE DE HOGDKIN [SIC] 

ET D'AFFECTIONS VOISINES. [STUDY OF NITRO 

GEN MUSTARD DERIVATIVES IN THE TREATMENT 

HODGKIN'S DISEASE AND RELATED DISEASES.] 

OF 

Bull. Soc. mÃ©d. hop. Paris. 1949, 65: 29- 

34. 

See 

2123 

NITROGEN MUSTARDS. 

(0-CHLORO- 

ETHYLAMINE, 

METHYL BIS- 

2125 

Gohr, H., Gorges, T. and Bolder, H. TIEREXPERI 

MENTELLE UND KLINISCHE UNTERSUCHUNGEN ÃœBER 

DIE TOXISCHE UND THERAPEUTISCHE WIRKUNG DER 

BEIDEN N -LOST -VERBINDUNGEN TRICHLOR TRIÃ„THYL- 

AMIN UND DICHLORDIÃ„THYLMETHYLAMIN. [EXPERI 

MENTAL AND CLINICAL STUDIES ON THE TOXIC AND 

THERAPEUTIC EFFECT OF TWO NITROGEN MUSTARD 

COMPOUNDS, TRICHLORTRIETHYLAMINE AND DICHLOR- 

DIETHYLAMINE.] Zschr. ges . inn. lied., 1953. 

8: 692-696. 26 refs. 

2126 

Karnofsky, D. A., Burchenal, J. H., Ormsbee, 

R. A., Cornman, I. and Rhoads. C. P. EXPERI 

MENTAL OBSERVATIONS ON THE USE OF THE NITRO 

GEN MUSTARDS IN THE TREATMENT OF NEOPLASTIC 

DISEASE. In: APPROACHES TO TUMOR CHEMOTHERA 

PY. Wash., Am. Ass. Advance. Sc., 1947, 

p. 293-305. 22 refs. 

2127 

Redondo ,Benito, M. LA MOSTAZA NITROGENADA EN 

TERAPEUTICA. [THERAPEUTIC APPLICATION OF 

- EFFECT ON MALIGNANT GROWTH 

2128 

Bass, A. D. and Feigelson, II. THE RESPONSE OF 

NORMAL AND MALIGNANT LYMPHOID TISSUE TO METHYL- 

B1S-Ã•/S -CHLOROETHYDAMINE AND ETHYL CARBAMATE 

(URETHANE) IN ADRENALECTOMIZED AND NON-ADRE- 

NALECTOMIZED MICE. Cancer Res., 1948, 8: 503- 

509. 8 refs. 

2129 

Buffa, P. LE CLORO-ALCHIL-AMINE (NITROGEN MUS 

TARDS) NELLA TERAPIA DI NEOPLASIE. DI EMOPATIE 

E DEL LINFOGRANULOMA. [THE CHLOROALKYLAMINES 

(NITROGEN MUSTARDS) IN THE TREATMENT OF NEO 

PLASIA, HEHOPATHY AND LYMPHOGRANULOMA.] 

Recenti prog. med., 1947, 2: 116-121. 4 refs. 

See 

1953 

2130 

Dagg, C. P., Karnofsky, D. A., Toolan, H. W. 

and Roddy, J. SERIAL PASSAGE OF HUMAN TUMORS 

IN CHICK EMBRYO: GROWTH INHIBITION BY NITRO 

GEN MUSTARD. Proc. SOC. Exp. 

1954, 87: 223-7. 13 refs. 

Biol., N. Y.,



124 

NITROGEN MUSTARDS. ETHYLAMINE, METHYL 

BIS-O-CHLORO-, â€”¿ EFFECT ON MALIGNANT 


2131 Johnson. E. P. NITROGEN MUSTARDS IN FOWL LEU 

COSIS. Science, 1948, 107: 40-42. Abstracted 

in: Excerpta med., Sect~T~5, 1948, 1^:No. 1408. 

2132 Klopp, C. T., Alford, T. C., Bateman, J., Berry, 

G. N. and Winship, T. FRACTIONATED INTRA- 

ARTERIAL CANCER; CHEMOTHERAPY WITH METHYL 

BIS AMINE HYDROCHLORIDE; A PRELIMINARY REPORT. 

Tr. Am. Surg. Ass., 1950, 68: 490-511. 24 

reÃs. 

"toller, P. C. and Casarini, A. COMPARISON OF 

CYTOLOGICAL EFFECTS INDUCED BY X-RAYS AND 

NITROGEN MUSTARD. Brit. J. Cancer, 1952, 

6- 173-185. 4 pi. 20 refs. Abstracted in: 

Chem. Abstr., 1952, 46: 11421h; Excerpta 

med., Sect. 2, 1953,"5: No. 4536. 

"Marinacelo, L. IL SIGNIFICATO BIOLOGICO DI 

ALCUNE LINFOPATIE SPERIMENTALI STUDIATO 

ATTRAVERSO L'AZIONE DELLE SOSTANZE CITO- 

STATICHE E ANTIMITOTICHE. [BIOLOGIC SIG 

NIFICANCE OF EXPERIMENTAL LYMPHOPATHIES 

WITH RESPECT TO ACTION OF CYTOSTATIC AND 

ANTIMITOTIC SUBSTANCES.] Arch, sc. med., 

Tor., 1952, 93: 509-540. 

2135 

Miyali T Kato, K. and Shibano, S. THE INHI 

BITING EFFECT OF NITROGEN MUSTARD AND OTHER 

MEDICAMENTS ON YOSHIDA SARCOMA. Gann, Tokyo, 

1949, 40: 147-149. In Japanese. 

21Miyazima, S. 6 CASES OF PULMONARY CANCER, 

TREATED WITH NITROGEN-MUSTARD. Gann, Tokyo, 

1952, 43: 316-317. In Japanese. 

2137 Pedersen, E. ON THE TREATMENT OF SPONTANEOUS 

LEUKEMIA IN MICE WITH NITROGENIZED MUSTARD 

GAS. Acta path, microb. scand., 1950, 27: 

9-15. 6 refs. 

"Â¡chreck, R. A COMPARISON OF THE REACTION OF 

CELLS TO NITROGEN MUSTARD AND X-RAYS. Acta 


848-856. Translations of summary: p. 855- 

856. Abstracted in: Chem. Abstr., 1952, 

4Â£: 3641h. 

9139 Schullenberger, C. C. and Watkins, C. H. EF 

FECTS OF NITROGEN MUSTARD ON THE BONE MARROW 

IN POLYCYTHEMIA VERA. Ann. Int. M., 1950, 

33: 841-853. 10 refs. 

21Streicher H J. CYTOLOGISCHE BEOBACHTUNGEN 

NACH INTRAPLEURALER LOSTTHERAPIE BEI 5 FALLEN 

VON CARCINOMATOSER PLEURÃ•TIS. [CYTOLOGICAL 

FINDINGS FOLLOWING INTRAPLEURAL NITROGEN MUS 

TARD THERAPY IN 5 CASES OF CARCINOMATOUS 

PLEURISY.] Arch. klin. Chir., 1950, 266: 

55-73 11 refs. Abstracted in: Excerpta 

ned., Sect. 5, 1951, 4: No. 2454. 

2141 4L , storer J. B. and Lushbaugh, C. C. 

S 

Chem. 

. 

r., 1952, 46: 4673ÃŒ. 

21vLhida S Hattori, O. and Eri, A. GROWTH 

Y INHÃŽIÃŽT?NG EFFECTS'OF SEVERALCHEMOTHERAPEU- 

TIC AGENTS ON l^l^SmCO^ Nisshin 

igaku, 1953, 40: No. 11, 603-606. .> 

summary. 

2143 Zhdanov, G, L. RATSIONAL'NYÃ•PODKHODK METODIKE 

LECHENIIA OPUKHOLEIGALOIDOALKILAMINAMI I ETILEN- 

IMINAMI. [ON THE TREATMENTOF CANCERWITH HALOID 

ALKYLAMINESANDETHYLENIMINE.] BÃŽÃ11. eksp. biol. 

med., 1955, 40: No. 9, 65-69. 6 refs. Embikhin 

or methyl-bisÂ-chloroethylamine hydrochloride 

and triethylenimine-s-triazine or TET were in 

jected into rats with sarcoma 45. Both compounds 

greatly inhibited tumor growth, especially if 

the initial dosage was high and was then gradually 

decreased. Both compounds also showed effects on 

the blood picture and normal organs of the ex 

perimental animals. 

See 

308 

2398 

322 

2651 

742 2266 2339 

- EFFECT ON NORMAL GROWTH 

21Alfieri, A. AZIONE DEL CLORIDRATO DI METIL BIS 

(BETACLOROETIL) AMINA (CLORAMIN) SUL MIOCARDIO 

DI EMBRIONE DI POLLOCOLTIVATO IN VITRO. 

FACTIONOFTHEHYDROCHLORATE OF METHYL-BIS 

(BETA-CHLORETHYL)AMINE (CHLORAMINE)ON THE 

MYOCARDIUMOF CHICKEN EMBRYOCULTIVATEDIN 

VITRO.] Oncologia, Roma, 1949, 23: 119-122. 


5, 1950, 3: No. 

Alfieri, A. AZIONE DEL CLORIDRATO DI METIL-BIS- 

BETACLOROETIL-AMINA (CLORAMIN) SUL MIOCARDIO 

DI EMBRIONE DI POLLO DI SEI-OTTO GIORNI COLTI 

VATO IN VITRO. [EFFECT OF HYDROCHLORIDE OF 

METHYL-BIS-ÃŸ-CHLOROETHYL AMINE (CHLORAMINE) 

ON THE MYOCARDIUMOF A SIX-TO-EIGHT DAY OLD 

CHICK EMBRYO IN VITRO.] Boll. Soc . ital . 

biol. sper., 1949, 25: 532-533. This essen 

tially the same as Ã¯B"ereport in: Oncologia, 

1949, 29: 119-122. 

2146 Baserga, A. and Marinone. G. ANALYSE DE L 'ACTION tAC! 

DES MOUTARDES A L'AZOTÃŽ SUR L 'HÃ‰MATOPOÃ•ÃˆSE . 

[ANALYSIS OF THE ACTION OF 

ON HAEMATOPOIESIS.] Sang, 

NITROGEN MUSTARDS 

Par., 1948, 19: 381- 

388. Abstracted in: Chem. Abstr., 1950, 44: 

No. 756h. 

2147 Bastrup-Madsen, P. ACTION OF NITROGEN MUSTARD, 

POTASSIUM ARSENITE, AND URETHANE ON LIVING 

CELLS IN VITRO. Sang, Par., 1950, 21: 345- 

348. Abstracted in: Excerpta med., "Sect. 5, 

1950, 3: No. 3510; Chem. Abstr., 1950, 44: 

No. 85Ã¯4b. 

2148 Bastrup-Madsen, P. ACTION OF NITROGEN MUSTARDS 

AND POTASSIUM ARSENITE ON LIVING CELLS IN 

VITRO, WITH PARTICULAR REFERENCE TO THEIR 

INFLUENCE ON CELL DIVISION. 116p. Aarhus, 

Universitetsforlaget, 1950, 108 refs. 

NFN) ON ERYTHROPOIESIS IN VITRO. Acta pharm. 

tox., Kbh., 1951, 7: 23-34. 7 refs. 

21Bodenstein, D. THE EFFECT OF NITROGEN MUSTARDS 

ON PROLIFERATING EMBRYONIC TISSUES. Cancer 

Res., 1947, 7: 49-50. 

2151 Bodenstein, D. THE EFFECTS OF NITROGEN MUSTARD 

ON EMBRYONIC AMPHIBIAN DEVELOPMENT. PART I. 

ECTODERMAL EFFECTS. J. Exp. Zool., 1947, 104: 

311-341. 1 pi. 11 refs.



125 


BIS-(/3-CHLORO-, â€”¿ EFFECT ON NORMAL 


2152 

Bodenstein, D. THE EFFECTS OF NITROGEN BUSTARD 

ON EMBRYONIC AMPHIBIAN DEVELOPMENT. II. EF 

FECTS ON EYE DEVELOPMENT. J. Exp. ZoÃl., 

1948, 108: 93-125. A histological study. 

"Certain cells broke down rather rapidly 

after the embryos were exposed, while other 

cells enlarged greatly. In these latter 

cells mitosis was arrested in the interphase, 

but growth continued; finally 

cells broke down also." 

these large 

2153 

Bodenstein, D. EFFECTS OF RADIOMIMETIC SUB 

STANCES ON EMBRYONIC DEVELOPMENT, WITH 

SPECIAL REFERENCE TO 

J. Cellul. Physiol., 

NITROGEN MUSTARDS. 

1954, 43: 179-205. 

Discussion: p. 192-204. 19 refs. Abstract 

ed in: Excerpta med., Sect. 16, 1955, 3: 

No. 3087; Leukemia Abstr., 1954, 2: No. 818. 

2154 

Brown, A. and Davis, L. J. THE HAEMATOLOGICAL 

EFFECTS OF NITROGEN MUSTARD THERAPY WITH 

SPECIAL 

STERNAL 

REFERENCE TO 

BONE MARROW.' 

THE CYTOLOGY OF 

Glasgow M. J., 

THE 

1950, 

31: 93-113. 5 pi. 11 rets. 

2155 

Cameron, G. R., Courtier, f. C, and Jones, R. P. 

THE EFFECTS OF 2,2'-DICHLORODIETHYLMETHYLAMINE 

HYDROCHLORIDE ON THE BLOOD-FORMING TISSUES. 

J. Path. Bact., Lond., 1947, 59: 425-435. 

1 pi. 4 refs. Abstracted in: Chem. Abstr., 

1948, 42: 2025a. 

2156 Cardinali, G. AZIONE DEL CLORIDRATO DI METIL- 

BIS ( t>-CLOROETIL)AMINA (CLORAMIN) SUI 

FIBROBLASTI DI POLLO COLTIVATI IN VITRO. 

[ACTION OF THE HYDROCHLORATE OF METHYL-BIS 

(BETA-CHLORETHYL) AMINE (CHLORAMINE) ON 

FIBROBLASTS CULTIVATED IN VITRO.] Oncologia, 

Roma, 1949, 23: 107-118. 22 refs. Abstract 

ed in: ExcerpTa med., Sect. 5, 3J 1950, No. 

710. "...At high concentrations (10-3 and 

10"*), mitoses are blocked in metaphase and 

ruptures of the nuclei are visible; at lower 

(10-5 an(1 10-6) concentrations, anaphases 

are diminished and steatosis increases. This 

effect may be referred to inhibition of the 

enzymatic systems or to a direct combination 

of the nitrogen mustard with the polypeptide 

chains of genes." 

2157 

Falcone, G. AZIONE FILAMENTIZZANTE DELLA METIL- 

BIS CÂ¿-CLOROETIDAMINA SU E. COLI. [THE FILA 

MENT-FORMING ACTION OF METHYL-BIS(/) -CHLORO- 

ETHYL)AMINE ON ESCHERICHIA COLI.] Boll. Soc. 

ital. biol. sper., 1953, 29: 702-703. 8 refs. 

Sublethal doses of nitrogen" mustard inhibit 

cytoplasmic division without affecting the 

growth of the bacteria. 

2158 Fell, H. B. and Allsopp, C. B. TISSUE CULTURE 

EXPERIMENTS ON THE BIOLOGICAL ACTION OF METHYL- 

BIS (/3-CHLORETHYDAMINE AND ITS HYDROLYSIS 

PRODUCTS. Cancer Res., 1949, 9: 238-246. 

10 refs. Abstracted in: Excerpta med., Sect. 5, 

1949, 2: No. 3549; Chem. Abstr., 1949, 43: 

No. 5503a. 

2159 For teza Bover, G., Baguena Candela, R., Marco 

Orts, F. and Calvo Garra. W. WIRKUNG WIEDER 

HOLTER MASSIVER DOSEN VON NITROGEN-MUSTARD 

(METHYL-BIS- Â¿3-CHLORÃ„THYLAMIN)AUF BLUTBILD 

UND HÃ„MOPOETISCHE ORGANE DES KANINCHENS. 

[EFFECT OF REPEATED LARGE DOSES OF NITROGEN 

MUSTARD (METHYL-B IS- /3-CHLORETHYL AMINE )ON 

BLOOD PICTURE AND HEMOPOIETIC ORGANS OF THE 

RABBIT.] Acta haemat., Basel, 1950, 3: 

323-336. 6 refs. 

2160 

Gillette, R. and Bodenstein, D. SPECIFIC DE 

VELOPMENTAL INHIBITIONS PRODUCED IN AMPHI 

BIAN EMBRYOS BY A NITROGEN MUSTARD COMPOUND. 

J. Exp. Zool., 1946, 103: 1-32. 10 refs. 

"...proliferating regions were selectively 

affected to the exclusion of non-prolifera 

ting regions, and furthermore, that even 

within the single cell proliferation was 

inhibited, while other 

gave the appearance of 

features of the cell 

normal function." 

2161 Goldeck, H. STICKSTOFF-LOST-EINFLUSS AUF DIE 

KANINCHEN-SPERMIOGENESE. [EFFECT OF NITROGEN 

MUSTARD ON SPERMATOGENESIS IN RABBITS.] 

Klin. Wschr., 1950, 28: 620-621. 1 rÃ©f. 

Sections of the testicles of rabbits which 

were injected with nitrogen mustard showed 

that the cellular proliferation is inhi 

bited in these as well as in other tissues, 

while spermatogenesis showed a marked retro 

gression. 

2162 Greco, G..and Pisani, D. RICERCHE SPERIMENTALI 

CON AZOIPRITE NEL CONIGLIO CON SPECIALE RI 

FERIMENTO ALLE MODIFICAZIONI EMATOLOGICHE E 

SPLENOEPATICHE. [EXPERIMENTAL STUDIES WITH 

NITROGEN MUSTARD IN THE RABBIT WITH REFERENCE 

TO CHANGES IN THE BLOOD, 

Sperimentale, 1951. 100: 

SPLEEN, AND LIVER.] 


in: Chem. Abstr., 195T7 45: 4833g. 

2163 

Haskin, D. SOME EFFECTS OF NITROGEN MUSTARD ON 

THE DEVELOPMENT OF EXTERNAL BODY FORM IN THE 

FETAL RAT. Anat. Ree., 1948, 102: 493-511. 

pi. Appro*. 40 refs. 

2164 

Hutchens, J. O. and Podolsky, B. THE EFFECT 

OF NITROGEN MUSTARDS ON CELL DIVISION IN 

CHILOMONAS PARAMECIUM AND SACCHAROMYCES 

CEREVISIAE. 

205-228. 18 

J. Cellul. 

refs. 

Physiol., 1954, 43: 

2165 

Jordan, M. WPLYW METYLO-DWA-( ft-CHLOROETYLO)- 

AMINY IPERYTU AZOTOWEGO NA ROZWÃ›J JAJ ROBAKA 

TUBIFEX(SP). INFLUENCE DE LA METHYL-BIS( (b - 

CHLOR-ETHYL)-AMINE YPÃ‰RITE AZOTIQUE SUR LE 

DEVELOPPEMENT DES OEUFS DU TUBIFEX(SP). 

[INFLUENCE OF METHYLBIS(2-CHLOROETHYL)AMINE 

ON THE DEVELOPMENT OF THE EGGS OF TUBIFEX SP.] 

Bull, internat. Acad. polon. se., cl. med., 


Chem. SbTFr., 1949, 43: 1322b. 

2166 Lamotte, W. O., Jr. and Leopold, I. H. THE 

PATHOLOGIC CHANGES IN RABBIT EYES RESULTING 

FROM EXPOSURE TO LIQUID NITROGEN MUSTARDS. 

Am. J. Ophth., 1946, 29: 1553-1562. 5 refs. 

2167 

Marks, E. K., Gaston, E. O., Jacobson, L. O. 

and Block, M. THE HEMATOLOGIC EFFECTS OF 

NITROGEN MUSTARDS. Am. 

15_: 59-66. 11 refs. 

J. M. Techn., 1949 

2168 

Maumenee, A. E. and Scholz, H. 0. THE HISTO- 

PATHOLOGY OF THE OCULAR LESIONS PRODUCED BY 

THE SULFUR AND NITROGEN MUSTARDS. Bull. 


8 refs. 

2169 

Osgood, E. E. and Chu, I. T. THE EFFECT OF NI 

TROGEN MUSTARD ON GRANULOCYTIC CELLS AS OB 

SERVED BY THE MARROW CULTURE TECHN1C. Cancer 

Res., 1950, 10: 98-102. 24 refs. Methylbis-ÃŸ 

-chlorÃe~thylamine hydrochloride differs 

in action from ionizing radiation, colchicine 

or urethane on cells of the granulocytic 

series. "The nitrogen mustard stops differen 

tiation and kills all cells less differentiated 

than the segmented neutrophil but has little 

or no effect on the life-span of the segmented 

neutrophil. Cell death occurs exponentially, 

and equal percentages of the surviving cells 

are killed in equal time-intervals."



126 

NITROGEN MUSTARDS.ETHYLAMINE, METHYL 

BIS-(0-CHLORO-, â€”¿ EFFECT ON NORMAL 


170 

RÂ»bertson, J. S. AN ANALYSIS OF THE EFFECTS OF 

Â£,ÃŸ'-DICHLORODIETHYLAMINE HYDROCHLORIDE AND 

OF FORMALIN ON THE WEIGHT OF THE LTMPHOID OR 

GANS OF INTACT AND ADRENALIZED MICE. J. Path. 

Bact., Lond., 1949, 61: 619-634. 53 reta. 

Abstracted in: Chem.~A"bstr., 1950, 44: 6030g. 

2171 

Schoch, E. P., Jr. and Click, D. THE EFFECT 

OF COLD STRESS, ACTH, CORTISONE, PYROGEN, 

AND NITROGEN MUSTARD ON TISSUE MAST CELLS IN 

THE SKIN AND SUBCUTANEOUS TISSUES OF THE RAT. 

J. Invest. Derm., 1953, 20: 119-132. 25 refs. 

Discussion: p. 131-132. ~ 

2172 

Sentein, P. ACTION DE L'YPÃ‰RITE NITRÃ‰E SUR 

L.ES MITOSES DE SEGMENTATION; LES CELLULES 

EPITHELIALES ET LES CELLULES GERMINALES 

CHEZ TRITURUS HELVETICUS RAZ. [EFFECT OF 

NITROGEN MUSTARD ON SEGMENTATION MITOSIS, 

EPITHELIAL AND GERMINAL CELLS IN TRITURUS 

HELVETICUS RAZ.] C. rend. Soc. biol., 1955, 

149: 167-169. 

2173 

Webber, B., Craig, B. R. and Friedman, N. B. 

CELLULAR DYNAMICS IN THE INTESTINAL MUCOSA; 

QUANTITATIVE MEASUREMENTS OF THE EFFECTS OF 

NITROGEN MUSTARD AND IRRADIATION ON CELLULAR 

DIVISION 

1951, 4: 

AND DIFFERENTIATION. Cancer, 

1250-1258. 2 pi. 17 refs. 

N. Y., 

2174 

Zaceo, M. and Ciasca, G. CLOROAMINE ANERGIA 

MESENCHIMALE. [NITROGEN MUSTARDS AND MESEN- 

CHYMAL ANERGY.] 

7: 105-106. 

Experientia, Basel, 1951. 

See 

229 273 362 1935 2336 

See 

EFFECT ON TUMOR GROWTH IN PLANTS 

1024 1335 


2175 

Bevacqua. V. and Garavaglia, G.P. AZIONE 

INIBITHICE DELLA CISTE1NA SULLA LEUCOPENIA 

PROVOCATA DAL TRATTAMENTO CON AZOMOSTARDA. 

[INHIBITORY EFFECT OF CYSTEINE ON LEUKOPENIA 

PRODUCED BY NITROGEN MUSTARD.] Haematologica, 

Pavia, 1954, 38: 939-950. 32 refs. English 

summary. "Nitrogen mustard induces leukopenia 

through inhibition of the proliferation and 

probably the maturation of white blood cells. 

Cysteine has a protective effect as it di 

minishes the blockage, induced by nitrogen 

mustard on the 

the maturation 

proliferation and probably 

of the leukocytes." 

2176 

Chen, G. THE EFFECT OF METHYLBIS(2-CHLOROETHYL)- 

AMINE ON TRYPANOSOMA EQUIPERDUM. J. Infect. 

Dis., 1948, 82: 133-137. Abstracted in: Chem. 

Abstr., 19487~42: 8339b. 

2177 Jacobson, L. O., Marks, E. K., Gaston, E. and 

Block, M. H. THE EFFECTS OF NITROGEN MUSTARD 

ON INDUCED ERYTHROBLASTIC HYPERPLASIA IN RAB 

BITS. J. Laborat. Clin. M., 1949, 34: 902- 

924. tab. 10 refs. Abstracted inT~Excerpta 

med., Sect. 5, 1950, 3: No. 415. 

2178 Weisberger, A. S. and Heinle, R. W. THE PRO 

TECTIVE EFFECT OF CYSTEINE ON LEUCOPENIA IN 

DUCED BY NITROGEN MUSTARD. J. Laborat. Clin. 

M., 1950, 36: 872-876. Abstracted in: Chem. 

Abstr., 195T, 45: 8660a. 

2195 

EFFECTS, ENHANCEMENT OF 

2179 

Peczenik, O. INFLUENCE OF CYSTEINAMINE, METHYL 

AMINE. AND CORTISONE ON THE TOXICITY AND ACTI 

VITY 

172; 

OF NITROGEN MUSTARD. 

454-455. 6 refs. 

Nature, Lond., 1953, 

2180 Weisberger, A. S., Heinle, B. W. and Levine, B. 

THE EFFECT OF L-CYSTEINE ON NITROGEN MUSTARD 

THERAPY. Amer. J. M. Se., 1952, 224: 201-211. 

8 refs. Abstracted in: Excerpta BeTI., Sect. 

16, 1954, 2: No. 1707; Chem. Abstr., 1952, 

46: 11453c7 

2181 Weisberger, A. S., Heinle, R. W. and Levine, B. 

SOME STRUCTURAL REQUIREMENTS FOR'THE PREVEN 

TION OF LEUKOPENIA INDUCED BY NITROGEN MUS 

TARD. J. Clin. Invest., 1952, 3_1: 217-222. 


2, 1953. 6: No. 512. Leucopenia due to nitro 

gen mustard "is modified by compounds posses 

sing vicinal sulphydryl, amino and carboxyl 

groups, of which cysteine is the most effective; 

D, L-homocysteine and glutathione are less ef 

fective. Substitution or alteration of the 

free sulphydryl, amino or carboxyl group in 

each case abolishes this protective effect. 

The findings suggest that the protective 

action of L-cysteine, in vivo, is brought 

about by the protection of one or more sub 

stances essential for leucopoiesis, rather 

than solely by the direct inactivation of the 

nitrogen mustard itself," - Excerpta med. 

2182 

Â»eisberger, A. S. and Storaasli, J. P. OPTICAL 

ISOMERS OF CYSTEINE IN THE PREVENTION OF LEU 

KOPENIA INDUCED BY NITROGEN MUSTARD. J. 

Laborat. Clin. Med., 1954, 43: 

D-cysteine is not as effective 

246 252. 4 refs. 

as L-cysteine 

in modifying leukopenia and 

to nitrogen mustard (HN2). 

neutropenia due 

"Thus a specific 

spatial configuration as well as the presence 

of a sulfhydryl, amino, and carboxyl group 

in close apposition appears to be required 

for preventing the leukotoxic effect of HN2." 

676 

METABOLISM(mCLUDING EFFECTS ON METABOLIC 

PROCESSES) 

2183 

Baratta, P. F., Lorenzini, R. and Busani, L. 

COMPORTAMENTO DELLA PLASMALI PAS I TRIBUTIRRINO- 

LITICA NELL'INTOSSICAZIONE SPERIMENTALE DA 

AZOIPRITE. [PLASMA TRIBUTYRIN LIPASE IN EX 

PERIMENTAL NITROGEN MUSTARD POISONING.] Rass. 

fisiopat., 1952, 24: 867-872. Approx. 12 refs. 

2184 

Baratta, P. F., Lorenzini. R. and Busani, L. 

CRASI PROTEICO-PLASMÃ•TICANELL'INTOSSICAZIONE 

CRONICA DA AZOIPRITE (DICLORODIETILMETILAMINA). 

[PLASMA PROTEIN PICTURE IN CHRONIC INTOXICA 

TION DUE TO METHYL-BIS-C /i-CHLOROETHYL)AMINE.] 

Gior. clin, med., 1951, 32: 398-401. 7 refs. 

2185 

Bierman, R. R., Strait, L. A. and Hrenoff, M. K. 

EXCRETION OF URINARY COPROPORPHYRINS IN PATIENTS 

WITH NEOPLASTIC DISEASES TREATED WITH METHYL- 

BIS(,i -CHLOROETHYL)AHINE HYDROCHLORIDE (HN2) . 

J. Nat. Cancer Inst., 1949, 10; 93-103. 14 refs.



127 


BIS-/3-CHLORO-, â€”¿METABOLISM (INCLUDING 

EFFECTS ON METABOLIC PROCESSES) 

(Continued) 

2186 

Bodenstein, D. and Kondritzer, A. A. THE 

EFFECT OF NITROGEN MUSTARD ON NUCLEIC ACIDS 

DURING EMBRYONIC AMPHIBIAN DEVELOPMENT. J. 

Exp. Zool., 1948, 107: 109-121. 16 reÃs. 


No. 30861. 

2187 

Burnop, V. C. E., Richards, D. E., Watkins, W. M. 

and Wormall, A. COMBINATION OF NITROGEN-15 

LABELLED NITROGEN MUSTARD WITH PROTEINS. 

Nature, Lond., 1951, 168: 251-252. 5 reÃs. 

Abstracted in: ExcerpTS~med., Sect. 2, 1952, 

5: No. 4508. 

2188 

Butler, J. A. V. and Smith, K. A. THE ACTION 

OF IONIZING RADIATIONS AND OF RADIOMIMETIC 

SUBSTANCESON DEOXYRIBONUCLEICACID. Part I. 

THE ACTION OF SOMECOMPOUNDSOF THE "MUSTARD" 

TYPE. J. Chem. Soc., Lond., 1950, pt. 4, 

3411-3418. 

2189 

Butler, J. A. V., Gilbert, L. A. and Smith, K, A. 

RADIOMIMETIC ACTION OF SULPHUR 

'MUSTARDS' ON DEOXYRIBONUCLEIC 

AND NITROGEN 

ACID. Nature, 

Lond., 1950, 165: 714-716. 14 rets. Abstracted 

in: Excerpta mea.. Sect. 2, 1951, 4: No. 1049; 

Chem. Abstr., 1950, 44: 7439a. 

2190 Butler, J. A. V., Gilbert, L., Jams, D. W. F. 

and Ross, W. C. J. DEGRADATIONOF DEOXY 

RIBONUCLEICACID BY A 'NITROGEN MUSTARD'. 

Nature, 1951, 168: 985. 7 refs. 

2191 Caputo, A. OSSERVAZIONI SULL'AZIONE DEPRIMENTE 

LA GLICOLISI AEROBIADEI TUMORIMESENCHIHALI 

ESERCITATA DALLE AZOTIPRITI. [THE DEPRESSANT 

ACTION OF NITROGENMUSTARDSON THE AEROBIC 

GLYCOLYSIS OF MESENCHYMALTUMORS.] Rass. mod. 

sarda, 1950, 52: 658-665. 5 refs. 

2192 Caselli, P. AZIONE DELL'AZOIPRITE SULLA GLICOLISI 

DI TESSUTTI NEOPLASTICI MESENCHIMALI. [THE 

EFFECT OF NITROGEN MUSTARD ON THE GLYCOLYSIS 

OF NEOPLASTIC TISSUE OF THE MESENCHYME.] Tumori, 

Milano, 1950, 24: 370-373. 4 refs. Nitrogen 

mustard lowers~lte tumor glycolysis. 

2193 Cattaneo, I. IL COMPORTAMENTO DELLE OSSIDASI 

E PEROSSIDASI LEUCOCITARIE NELLA INTOSSICA 

ZIONE SPERIMENTALE DA AZOIPRITE. [BEHAVIOR 

OF LEUKOCYTE OXIDASE AND PEROXIDASE IN EX 

PERIMENTAL INTOXICATION BY NITROGEN MUSTARD]. 

Haematologica, Pavia, 1950, 34; 473-488. 

22 refs. 

2194 

Closon, J. and Heusghem, C. EXCRÃ‰TIONURINAIRE 

DES 17-CÃ‰TOSTÃ‰ROÃŒDES CHEZ DES PATIENTS ATTEINTS 

DE NEOPLASIE MALIGNEET TRAITÃ‰SPAR UNE YPERITE 

A L'AZOTE (METHYL-BIS-CHLORETHYLAMINE) . 

[URINARY EXCRETION OF 17-KETOSTEROIDS IN PA 

TIENTS WITH MALIGNANTNEOPLASTIC DISEASE TREATED 

WITH NITROGENMUSTARD(METHYL-BIS-CHLORETHYL- 

AMINE).] Ann. endocr., Par., 1952, 13: 400- 

406. 17 refs. 

2195 

Colter, H. S. and Quastel, J. H. PROTECTION OF 

ENZYMES BY ANTICHOLINE-OXIDASES AGAINST IN- 

ACTIVATION BY NITROGEN MUSTARD. Nature, Lond., 

1950, 166: 773-775. 

ExcerpÃ¯5~med., Sect. 

12 refs. 

2, 1952, 

abstracted 

5: No. 149. 

in: 

2196 

Costa, E. AZIONE DI UN AZOIPRITE SULLA JALURO- 

NIDASI. [EFFECT OF A NITROGEN MUSTARD ON 

HYALURONIDASE. 

1950, 34: 375 

Arch. Se. bini.. Bologna, 

7. 21 refs. 

2197 

Danowski, T. S., Greemnan, L., Cow, R. C., Weigand, 

F. W., Mateer, F. M., Peters, J. H., Cosgrove, 

E. F., Seiferth, W. and Davis, N. ELECTROLYTE 

AND NITROGEN BALANCE STUDIES IN PATIENTS RE 

CEIVING A NITROGEN MUSTARD. J. Pharm. Exp. 

Ther., 1950, 98: 147-152. 20 refs. "Adult 

patients ill 'with neoplastic disease were studied 

by the balance method before, during, and after 

treatment with methyl bis(beta-chloroethyl)amine. 

No evidences of significant or consistent al 

teration in the exchanges of electrolytes or 

nitrogen were observed." 

2198 Dietz, A. A. and Steinberg, B. CHEMICALCOM 

POSITION OF BONE MARROWAFTER EXPOSUREOF 

RABBITSTONITROGENMUSTARD.Arch. Biochem., 

N. Y., 1952, 38: 129-138. 26 refs. 

2199 

Feinstein, R. N. and Botkin, A. L. EFFECT OF 

NITROGEN 

INFORMAL 

MUSTARD ON 

BI-MONTHLY 

TISSUE CATHEPSINS. 

PROGRESS REPORT ON 

IN: 

TOXI- 

CITY AND IRRITANCY OF CHEMICAL AGENTS (UNI 

VERSITY OF CHICAGO TOXICITY LABORATORY) CHIC., 

1947, Suppl. A, Informal Rep. No. N. S. 18, 

p. 36-42. 13 refs. In nine experiments bisy3-chloroethylmethylamlne 

or HN2-HCL was ad 

ministered Intravenously to male rats of the 

Maguran strain in 0.25 mg. doses. The studies 

seem to indicate changes in the catheptic 

activity of spleen and intestine but not of 

the liver or kidneys. The changes may be 

due to alterations in the cellular or chemi 

cal composition of the affected tissues. 

A preliminary report. 

2200 

Feinstein, R. N. and Botkin, A. L. EFFECT OF 

NITROGEN 

INFORMAL 

MUSTARD ON 

BI-MONTHLY 

TISSUE CATHEPSINS. IN: 

PROGRESS REPORT ON TOXI 

CITY AND IRRITANCY OF CHEMICAL AGENTS (UNI 

VERSITY OF CHICAGO TOXICITY LABORATORY) 

CHIC., 

20, p. 

1947, Suppl. A, 

43-55. 5 refs. 

Informal Rep. No. N.S. 

A continuation of 

the 

No. 

studies reported in: Informal report 

N.S. 20 of this series. "The present 

paper offers more complete data on the pro 

blem together with a statistical analysis, 

and draws the conclusion that, while the 

nitrogen mustard, tus-f3 -chloroethylmethylamine(HN2) 

does apparently affect the cathepsins 

of spleen, and 

effects are mathematical 

intestine, 

artefacts 

these 

due,-in 

the first case, to decrease in spleen 

weight and, in the second 

in protein content of the 

case, to decrease 

intestine." 

2201 Fischer, P. and Lecomte, J. VARIATIONS DU GLU- 

TATHION REDUIT SANGUIN ET TISÃ‡ULAIRE APRES 

INJECTION DE METHYL-BIS-CHI.ORETHÃ•I.AMINE . 

[GLUTATHIONINE VARIATIONS IN THE BLOOD AND 

TISSUES FOLLOWING INJECTION WITH METHYL-BIS- 

CHLOROETHYLAMINE.] Rev. belge path., 1949, 

19: 267-271. 8 refs. 

2202 

Goldthwait, D. A. EFFECT OF NITROGEN MUSTARD 

ON NUCLEIC ACID METABOLISM. Proc. Soc. Exp. 

Biol., N. Y., 1952, 80: 503-504. 11 refs. 

Abstracted in: Chem.Tbstr., 1952, 46: 

104320. 

2203 

Â«Hawkins, R. D. and Mendel, B. CHOLINESTERASE. 

VI. SELECTIVE INHIBITION OF TRUE CHOLIN 

ESTERASE 

260-264. 

IN 

Abstracted 

VIVO. Biochem. 

in: Chem. 

J., 

Abstr.,~T949, 

1949, 44: 

43: 9103b.




BIS- (0-CHLORO-, â€”¿METABOLISM (INCLUDING 


(Continued) 

2204 

Karaahora, J., Senoo, T. and Terashima, H. FUR 

THER STUDIES ON THE ANEROBIC GLYCOLYSIS OF 

YOSHIDA SARCOMA, AND ON EFFECT OF NITROGEN 

MUSTARD AND p-CHLOR-MERCURI BENZOATE. Gann, 


2205 

Keibl, E., Spitzy, K. H. and Storch, L. I. ZUM 

PROBLEM DES LEUKOCYTENSTOFFWECHSELS. III. 

EINFLUSS VON N-LOST UND N-LOST URETHAN AUF 

DEN STOFFWECHSEL MYELOISCH-LEUKÃ„MISCHER ZELLEN. 

[THE PROBLEM OF LEUCOCYTE METABOLISM. III. 

EFFECTS OF NITROGEN MUSTARD WITH OR WITHOUT 

URETHANE ON THE METABOLISM OF MYELOID LEUKEMIC 

CELLS.] Arch. exp. Path., Beri., 1952, 214: 


med., Sect. 2, 1952, 5: No. 5796. 

220.5 

Keyser, J. W. EFFECT OF NITROGEN MUSTARD OR 

X- OR RADIUM-IRRADIATION TREATMENT ON THE 

LEVEL OF BLOOD SERUM PROTEIN-BOUND CARBO 

HYDRATE (POLYSACCHARIDE) IN PATIENTS WITH 

NEOPLASTIC DISEASES. Brit. J. Cancer, 1954, 

8: 238-250. 24 refs. "In patients treated 

with di(2-chloroethyl)methylamine hydrochloride, 

or by radium or x-irradiation, a favo 

rable clinical response was generally asso 

ciated with a fall in the blood serum polysaccharide(total 

and mucoprotein)toward 

normal levels. During treatment there often 

was a preliminary rise. With relapse the 

polysaccharide level again became elevated." 

2207 Lowrance, P. B. and Carter, C. E. THE EFFECT 

OF NITROGEN MUSTARDS ON THE METABOLISM OF 

NUCLEIC ACIDS IN THE HEMATOPOIETIC TISSUE OF 

THE RABBIT. J. Cellul. Physiol., 1950, 35: 


ned., Sect. 2, 1951, 4: No. 1048; Chem. Abstr., 

1950, 44: 9567c. 

22McKinney, G. R. THE EFFECT OF CERTAIN COMPOUNDS 

ON THE IN VITRO SYNTHESIS OF UREA AND ITS PRE 

CURSORS. J. Pharm. Exp. Ther., 1951, 101: 

345-352. Abstracted in: Chem. Abstr., 1951, 

45: 5810e. 

2209 McKinney, G. R. THE EFFECT OF A NITROGEN MUS 

TARD ON CERTAIN SYNTHETIC REACTIONS IN VITRO. 


12 refs. Abstracted in: Excerpta ned., Sect. 

2, 1950, 3: No. 1655; Chem. Abstr., 1949, 

43: 7139b7 The reactions studied were the 

conjugation of morphine and glucuronic acid, 

of phenol and sulfuric acid, of p-aminobenzoic 

acid and glycine, and urea synthesis. 

Methyl-bis-/a -chloroethylamine hydrochloride 

inhibited most of these reactions in varying 

degrees, which suggests separate mechanisms 

may be involved for each. 

Â¡210 

McKinney, G. R. EFFECT OF NITROGEN MUSTARD 

(METHYL-BIS-,Â«-CHLOROETHYLAMINE) ON CERTAIN 

SYNTHETIC REACTIONS IN VITRO. J. Pharm. 

Exp. Ther., 1949, 96; 188-192. 12 refs. 

2211 McKinney, G. R. EFFECT OF NITROGEN MUSTARD ON 

CYTOCHROME OXIDASE. Anat. Ree., 1948, 101: 

684-685. Abstracted in: Excerpta med.,"Sect. 

2, 1949, 2: No. 4482. 

22M?ller, Z. EFFECT OF METHYLBIS(2-CHLOROETHYL)- 

AMINÃ‰ON AEROBIC GLYCOLYSIS OF THYMUS LYM 

PHOCYTES. Proc. Soc. Exp. Biol., N. Y., 

1954, 87: 170-171. 12 refs. 

2213 

Miller, Z. B., Davison, C. and Smith, P. K. 

THE EFFECT OF PODOPHYLLOTOXIN, COLCHICINE, 

URETHANE AND NITROGEN MUSTARD ON THE RES 

PIRATION OF NORMAL AND SUPRARENALECTOMIZED 

RAT LYMPHATIC 

9Â£: 113-119. 

TISSUE. 

31 refs. 

J. Exp. M., 1950, 

2214 Mutolo, V. and Abrignani, F. INIBIZIONE DELL'AT 

TIVITÃ€ CATALASICA DA 2,2 DICLORO-N-METILDIETIL- 

AMINA CLORIDRATO. [INHIBITION OF CATALASE 

ACTIVITY BY 2:2'DICHLORO-N-METHYLDIETHYLAMINE 

HYDROCHLORIDE.] 

61-64. 2:2'dichloro-N-methyldiethylamine~ 

Oncologia, Basel, 1954, 7: 

hydrochloride in concentrations of 0.0028, 

0.0057 and 0.017. M, was found to inhibit the 

activity of catalase from beef liver. Other 

antimitotic drugs such as triethylenemelamine, 

colchicine and urethane did not inhibit the 

enzyme. 

2215 Podolsky, B. and Hutchens, J. O. SOME EFFECTS 

OF NITROGEN MUSTARDS ON METABOLISM OF CHI- 

LOMONAS PARAMECIUM AND SACCHAROMYCES CERE- 

VISIAE. J. Cellul. Physiol., 1954, 43: 229- 

245. 19 refs. 

2216 

Shimada, J., Sasaki, E. and Sugimoto, A. 

HISTOCHEMICAL STUDIES ON NUCLEIC ACIDS, 

PHOSPHATASES AND POLYSACCHARIDE IN 

YOSHIDA SARCOMA CELLS: EFFECTS OF NITRO 

GEN-MUSTARD. Gann, Tokyo, 1953, 44: 


2217 

Smith, K. A. and Press, E. M. THE DEGRADATION 

OF DEOXYPENTOSENUCLEIC ACID WITH RADIOMIMETIC 

CHEMICALS. Acta UniÃ³ internat, 

1951, 7: 537-542. 9 refs. 

cancr., Louvain, 

2218 

Simon, S.A. A NITROGÃ‰N-MUSTÃ‚RANYAG HATASA A 

gER OS ADAGOLT VtZ KIVÃ„LASZTÃ„SARAES A GYOMOR 

URULÃ‰SÃ‰RE. [EFFECT OF NITROGEN MUSTARDS ON 

THE EXCRETION OF WATER GIVEN BY MOUTH AND ON 

THE EMPTYING OF THE STOMACH.] Orv. hetil., 

1950, 91: No. 18, 556-558. 1.rÃ©f. Abstracted 


"Nitrogen mustards (0.5 mg subcutaneously) 

greatly reduce the emptying of 5 ml of water 

(administered by tube) from the stomach. This 

effect is chiefly responsible for the inhi 

bition of the excretion of water observed with 

albino rats. Nitrogen mustard treated animals 

excrete 

5 hours 

85% less urine than the controls within 

after the treatment." -Excerpta Â«ed. 

2219 Southam, C. M. and Goldsmith, Y. EFFECT OF 

NITROGEN MUSTARD ON SERUM COMPLEMENT IN VITRO 

AND IN PATIENTS WITH NEOPLASTIC DISEASE. 


432. 

993Ãœ 

Skipper, H. E., Bennett, L. L., Jr. and Langham, 

W. H. OVER-ALL TRACER STUDIES WITH C 14-LABELED 

NITROGEN MUSTARD IN NORMAL AND LEUKEMIC MICE. 

Cancer, N. Y., 1951, 4: 1025 1027. 9 refs. 

2221 

Teti, M. SULLA INIBIZIONE DELLA GLICOLISI 

AEROBIA ESERCITATA DALLA METIL BIS (BETA 

CLOROETIL) AMINA SU SEZIONI SOPRAVVIVENTI 

DI ALCUNI TUMORI SPERIMENTALI. [INHIBI 

TION OF AEROBIC GLYCOLYSIS BY METHYLBIS(2- 

CHLOROETHYL)AMINE IN SURVIVING SECTIONS OF 

SOME EXPERIMENTAL TUMORS.] Riv. Ist. 

sieroter, ital., 1951, 26: 112-119. Ab 

stracted in: Chem. Abstr., 1952, 46: 4129e. 

At 37Â° and in 5 hrs. contact time TO-5, 

10~6, and IO"7 g/1 nitrogen mustard causes 

77, 18, and 3%, respectively, inhibition of 

aerobic glycolysis of a uterine epithelioma.



129 

NITROGEN MUSTARDS. ETHYLAMINE METHYL 

BB-(/3-CHLORO-, â€”¿METABOLISM (INCLUDING 


(Continued) 

2222 

TrÃpodo, C. COMPORTAMENTO DEGLI ANTICORPI 

SERICI A SEGUITO DEL TRATTAMENTO PROLUNGATO 

CON AZOIPRITI. [THE SERUM ANTIBODIES AFTER 

PROLONGED TREATMENT WITH NITROGEN MUSTARDS.] 

Boll. Ist. sieroter, milan,, 1954, 33: 303- 


Sect. 16, 1955, 3: No. 3086. 

2223 

Ultmann, J. E., Hirschberg, E. and Gdlhorn, A, 

THE EFFECT OF NITROGEN MUSTARD ON THE CELLULAR 

CONCENTRATIONS OF NUCLEIC ACIDS IN REGENERA 

TING RAT LIVER. Cancer Res., 1953, K5: 14-20. 

pi. 44 refs. 

2224 Ward, D. N., Brandt, E. L. and Griffin, A. C. 

THE EFFECTS OF NITROGEN MUSTARD AND A PYRI- 

DINIUM COMPOUND ON THE PHOSPHORUS32 TURNOVER 

IN RAT LIVER DURING AZO-DYE CANCER INDUCTION. 


2225 

Watkins, W. M. and Wormall, A. THE IMMUNOLO- 

GICAL PROPERTIES OF PROTEINS TREATED WITH 

DI-2-CHLOROETHYLMETHYLAMINE. Biochem. J., 


Excerpta" med., Sect. 2, 1953, 6: No. 5453. 

See 

393MODE OF394ACTION 820 2423 2615 

2226 

Baunsteiner, II., Fellinger, K , Kolder, H. and 

Pukrseh, F. BEZIEHUNGEN IM WIRKUNGSMECHANIS 

MUS VON STICKSTOFFLOST UND ACTH. [RELATIONS 

BETWEEN MODES OF ACTION OF NITROGEN 

AND ACTH.] Klin, Â»sehr., 1952, 30: 

MUSTARD 

128-130. 

7 refs. 

2227 Betz, H., Heusghem, C. and Lecomte, J. ACTION 

D'UNE YPÃ‰RITE Ã€L'AZOTE (MÃ‰THYL-BIS-CHLORÃŠTHYL- 

AMINE) ET SYNDROME D'ALARME. [EFFECT OF A 

NITROGEN MUSTARD (METHYL-BIS-CHLOROETHYLAMINE) 

AND ALARM SYNDROME.] Rev. beige path., 1949, 

19: 251-266. 33 refs. 

2228 

Boneme, R. and Magat, M. SUR LE MODE D'ACTION 

DES SUBSTANCES RADIOMIMÃ‰TIQUES DU TYPE "MOU- 

TARDÃ•S AZOTÃ‰ES." [THE MODE OF ACTION OF 

RADIOMIMETIC SUBSTANCES OF THE NITROGEN-MUS 

TARD TYPE.] C. rend. Acad. se., 1951, 232: 

1104-1106. 7 refs. Abstracted in: ChemT"" 

Abstr., 1951, 45: 6289e. 

2229 Falcone, G. AZIONE FILAMENTIZZANTE DELLA METIL- 

BIS ( 0-CLOROETIL) AMINA SU E. COLI. [THE 

FILAMENT-FORMING ACTION OF METHYL-BIS - 

CHLOROETHYL) AMINE ON ESCHERICHIA COLI.] Boll. 

Soc. ital. biol. sper., 1953, 29: 702-703. 

8 refs. Sublethal doses of nitFogen mustard 

inhibit cytoplasmic division without affecting 

the growth of the bacteria. 

2230 

Griffin, A. C., Brandt, E. L. 

NITROGEN MUSTARD INHIBITION 

and Setter, V. 

OF AZO DYE CAR- 

CINOGENESIS. Cancer Res., 1951, 11: 868-872. 

21 refs. Abstracted in: Chem. Afistr., 1952, 

46: No. 4673h. 

2231 Grundmann, E. KARYOLOGISCHE UND KARYOMETRISCHE 

UNTERSUCHUNGEN AN LYMPHKNOTENPUNKTATEN BEI 

STICKSTOFF-LOST-THERAPIE. [KARYOLOGIC AND 

KARYOMETRIC STUDIES ON LYMPH NODE PUNCTATES 

DURING NITROGEN MUSTARD THERAPY]. Zschr. 

ges. exp. Med., 1952, 118: 489-523. 116 refs. 

2232 Ninni, M. L'ACTION LEUCOLYTIQUE DU SERUM DU 

SANG DANS LE MÃ‰CANISMED'ACTION DES DÃ‰RIVES 

AZOTÃ‰SDE L'HYPÃ‰RITE [SIC]. [THE LEUCOLYTIC 

ACTION 0F SERUM IN THE MECHANISM OF ACTION 

OF NITROGEN MUSTARDS]. Experientia, Basel, 

1950, 6: 21-22. Abstracted in: Excerpta med., 

Sect. 2, 1950, 3: No. 6958. 

2233 

Sugar, J. and Kellner, B. EFFECT OF ACUTE AND 

CHRONIC NITROGEN MUSTARD TREATMENT ON THE 

ORGANS OF THE RAT. Acta morph. hung., 1953, 


med., Sect. 5, 1954, 7: No. 874. A histological 

study of the effects of nitrogen mustard 

in 60 white rats. Three types of dosage vary 

ing from 75 -200 rag over a period of 3-155 days 

were used. Not only is nitrogen mustard antimitotic, 

but it also affects nuclear and cy 

toplasmic nucleoproteins. Cell destruction 

began 10 minutes after administration of drug 

and reached maximum effect 6 to 12 hours 

later. Comparing the action of nitrogen mus 

tard and colchicine it is found that the colchicine 

effect develops more slowly but re 

gresses more rapidly. 

2234 

Vannucchi, V. and Spigliati, P. CONTRIBUTO 

ALLO STUDIO SUL MECCANISMO 

POSTI AZO-IPRITICI; STUDIO 

DI AZIONE DEI COM 

CLÃ•NICO SUL COM 

PORTAMENTO DELLE REAZIONI OSSIDO-PEROSSIDA- 

SICHE. [MECHANISM OF ACTION OF NITROGEN 

MUSTARD COMPOUNDS. CLINICAL STUDY OF THE 

BEHAVIOR OF THE OXIDE-PEROXIDASE REACTION.] 


1038. 27 refs. Abstracted" in: Chem. Abstr., 

See 

2617 

1951, 45: 3502f. 


2235 

Baer, B. and Adori, A. KLINISCHE UND TIER 

EXPERIMENTELLE UNTERSUCHUNGEN ÃœBER DIE WIRKUNG 

EINIGER MODERNER CYTOSTATISCHER SUBSTANZEN AUF 

DIE PHAGOCYTOSEFÃ„HIGKEIT DER LEUKOCYTEN. 

[CLINICAL AND EXPERIMENTAL STUDIES ON THE EF 

FECT OF SOME MODERN CYTOSTATIC AGENTS ON THE 

PHAGOCYTIC ACTION OF LEUCOCYTES.] Klin. Wschr. 

1954, 32: 199-203. 24 refs. Phagocytic acti 

vity waÂ¥ studied in rabbits after the adminis 

tration of nitrogen mustard, in guinea pigs 

after the administration of colchicine and 

in patients with various tumors after 

administration of these two drugs and 

the 

urethane. 

Nitrogen mustard showed an inhibition 

of phagocytosis. Colchicine had no effect 

and the action of urethane was not conclusive. 

2236 

Bukantz, S. C., Dammin, G. J., Wilson, K. S., 

Johnson, M. C. and Alexander, H. L. INHIBI 

TORY EFFECT OF NITROGEN MUSTARD (BIS-BETA- 

CHLOROETHYL AMINE) ON LESIONS OF EXPERIMENTAL 

SERUM HYPERSENSITIVENESS. Proc. Soc. Exp. 

Biol., N. Y., 1949, 72: 21-26. 19 refs. 

223Y 

Cattaneo, I. RICERCHE SPERIMENTALI SULLE MODI 

FICAZIONI DELLA RESISTENZA GLOBULARE DEGLI 

ERITROCITI INDOTTE DAL CLORIDRATO DI METIL- 

BIS-BETA-CLOROETILAMINA. [EXPERIMENTAL RE 

SEARCH ON THE MODIFICATION OF THE GLOBULAR 

RESISTANCE OF ERYTHROCYTES PRODUCED BY METHYL- 

BISCft-CHLOROETHYDAMINE HYDROCHLORIDE. ] 

Haematologica, Pavia, 1949, 33J 911-928. 

63 refs.



130 


BIS-(0-CHLORO-, â€”¿ PHARMACOLOGICAL AND 

PHYSIOLOGICAL EFFECTS (Continued) 

2238 Daneo Sisto, L. and Daneo, V. POTERE LEUCO- 

LITICO DEL SIERO DI SANGUE DI INDIVIDUI 

TRATTATI CON IPRITE AZOTATA. [LEUKOLYTIC 

POTENCY OF BLOOD SERUM OF PATIENTS TREATED 

WITH NITROGEN MUSTARDS (CHLOROETHYLAMINES).] 

Minerva med., Tor., 1951, ^: 517-524. 

Appro*. 60 refs. English summary. 

2239 

Falcone, G. POLIMORFISMO BACTÃ‰RICO DA METIL- 

BIS(BETA-CLOROETIL)AMINA. [BACTERIAL POLY 

MORPHISM OWING TO METHYLBISC^ -CHLOROETHYL) 

AMINE.] Boll. Ist. sieroter, 

32: 339-344. 19 refs. 

milan., 1953, 

2240 

Italo, C. RICERCHE SPERIMENTALI SULLE MODIFI 

CAZIONI DELLA RESISTENZA GLOBULARE DEGLI 

ERITROCITI INDOTTE DAL CLORIDRATO DI METIL- 

BIS-BETA-CLOROETILAMINA. [EXPERIMENTAL RE 

SEARCH ON THE MODIFYING OF GLOBULAR RESIS 

TANCE OF ERYTHROCYTES INDUCED BY METHYL- 

BIS-/Ã•-HYDROCHLORIDE CHLOROETHYL AM INE. ] 

Haematologica, Pavia, 1949, 33: 911-928. 

Approx. 55 refs. English summary. 

2241 Jacobson, L. O., Marks, E. K., Gatson, E., Allen, 

J. G. and Block, M. H. THE EFFECT OF NITROGEN 

MUSTARD AND X-IRRADIATION ON BLOOD COAGULATION. 


12 refs. 

2242 

Leonardelli, G. B. and Pizzetti, F. MODIFICA 

ZIONI MORFOLOGICHE DEL TESSUTO LINFOEPITELIALE 

DELLA TONSILLA PALATINA DA AZOTOIPRITE. [MOR 

PHOLOGICAL MODIFICATIONS OF THE LYMPHOEPITHE- 

LIAL TISSUE OF THE PALATINE TONSIL AFTER 

TREATMENT WITH N-MUSTARD.] Minerva otorinolar., 

Tor., 1953, 3: 4-8. 8 refs. 

2243 

Â«Levin, W. C. EFFECT OF METHYL-BIS-(BETA-CHLO- 

ROETHYL)AMINE ON HEMOPOIETIC FUNCTIONS OF 

THE MARROW. Am. J. Med., 1948, 5: 311. 

2244 

Marinone, G. L'ACTION DE LA BIS-/3-CHLOROÃ‰THYL- 

AMINE CHLORHYDRIQUE SUR LE SANG ET LES ORGANES 

HEMOÃ‡OÃ•ETIQUES. ETUDE MORPHOLOGIQUE ET MOR- 

PHOGENETIQUE. [THE ACTION 0F BIS-/3-CHLOR- 

ETHYLAMINE HYDROCHLORIDE ON THE BLOOD AND BLOOD- 

FORMING ORGANS. MORPHOLOGIC AND MORPHOGENETIC 

STUDY.] Sang, Par., 1949, 20: 497-519. 62 refs. 

Abstracted in: Chem. Abstr., 1950, 44: 2656Ã•. 

2245 MenÃ©, G. L'AZIONE DELLA METIL-BIS(ft-CLOROETIL) 

AMINA, (AZOIPRITE) SULLA ATTIVITÃ€ GRANULO- 

PESSICA DEL SISTEMA RETICOLO-ENDOTELIALE. 

[EFFECT OF METHYL-BIS-(ft-CHLOROETHYL)AMINE 

ON GRANULOPECTIC ACTIVITY OF RETICULOENDO- 

THELIAL SYSTEM.) Policlinico sez. prat., 


2246 

Schlang, H. A. THE SHWARTZMAN PHENOMENON. I. 

INHIBITORY ACTION OF NITROGEN MUSTARD HNo. 


751. 

2247 

Schlang, H. A. SHWARTZMANPHENOMENON. II. 

SUPPRESSIVE ACTION OF HN2 ON ANTIGEN-ANTIBODY 

PROVOCATION. Proc. 

1952, 79: 639-640. 

Soc. Exp. 

6 refs. 

Biol., N. Y., 

2248 

Smith, T. R., Jacobson, L. O., Spurr, C. L., 

Allen, J. G. and Block, M. H. A COAGULATION 

DEFECT PRODUCED BY NITROGEN MUSTARD. Science, 

1948, 107: 474. 5 refs. 

2249 

Â«TrÃpodo,C. and Capaldo, A. COMPORTAMENTO DEL 

TEMPO DI PROTROMBINA, DEL FATTORE VI I E DEL 

TEMPO DI RICALCIFICAZIONE A SEGUITO DEL TRAT 

TAMENTO PROLUNGATO CON AZOIPRITI. [VARIATIONS 

OF THE PROTHROMBIN TIME, OF FACTOR VII AND OF 

THE RECALCIFICATION TIME AFTER PROLONGED TREAT 

MENT WITH NITROGEN MUSTARD.] Atti Accad. 

Pugliese se. Bari, 1953, 11: 3-27. tab. 

2250 

Â«Zanussi, C., Baratta, P. F., Berengo, A. and 

Busanti, L. SUL COMPORTAMENTODI ALCUNE 

ESPRESSIONI DELL'IMMUNITÃ€ NATURALE IN CORSO 

DI INTOSSICAZIONE CRONICA CON UNA AZOIPRITE 

(DICLORO-DIETIL-METILAMINA). I. POTERE 

COMPLEMENTARE DEL SIERO. [BEHAVIOUR OF SOME 

EXPRESSIONS OF NATURAL IMMUNITY DURING CHRO 

NIC POISONING WITH NITROGEN MUSTARD. I. 

COMPLEMENT POWER OF THE SERUM.] Boll. 

ital blol. sper., 1950, 26: 842-844. 

Soc. 

2251 Zimmerman, H. J., Alpert, L. K. and Howe, J. S. 

EFFECT OF NITROGEN MUSTARD(BIS-/9 -CHLOROETHYL- 

AMINE) ON LIVER FUNCTION AND STRUCTURE IN 

PATIENTS WITH NEOPLASTIC DISEASE. J. Laborat 

Clin. M., 1952, 40: 387-389. 5 refs. 

See 

432SYNERGISTIC 

435THERAPY 

ACTION 

2252 Albertelli, J., Monaco, H., O'Connor, T. and 

Bur, G. E. MOSTAZA NITROGENADA POR VIA ARTERIAL 

EN EL TRATAMIENTO DEL CANCER PELVIANO. [INTRA- 

ARTERIAL ADMINISTRATION OF NITROGEN MUSTARD IN 

THE TREATMENT OF PELVIC CANCER.] Prensa mÃ©d. 

argent., 1953, 40: 2085-2093. 4 refs. Ab 


No. 1706. 

2253 Albertelli, J., Monaco, H., O'Connor, T. and 

Bur, G. E. MOSTAZA NITROGENADA EN CAVIDADES 

SEROSAS PARA EL TRATAMIENTO DE TUMORES MALIG 

NOS PROPAGADOS. [NITROGEN MUSTARD IN SEROUS 

CAVITIES IN THE TREATMENT OF METASTASIZING 

MALIGNANT TUMORS.] Prensa, mÃ©d. argent., 


ExcerpÃ¯Ã¯med., Sect. 16, 1954, 2: No. 5073. 

". ,.intra-arterial injections oÃ¯"N-mustard 

in doses of 10 mg. were administered to ten 

patients...A striking effect is the dis 

appearance of effusions and the changes in 

the peripheral cells of the tumour, which do 

not involve the tumour mass ; the general 

toxic side-effects are very slight, so that 

this treatment is strongly recommended." 


2254 

Alder, A. ERFAHRUNGEN BEI DER BEHANDLUNG VON 

LYMPHOGRANULOMUND LEUKÃ„MIE MIT SENFGASVERBIN 

DUNGEN. [CLINICAL RESULTS IN NITROGEN MUS 

TARD TREATMENT OF LÃ•MPHOGRANULOMAND LEU 

KEMIA.] Schweiz, med. Wschr., 1948, 78; 

729-732. 

2255 Aleksandrowicz, J. LECIVE VLASTNOSTI NITROGRANULO- 

GENU. [THERAPEUTIC PROPERTIES OF NITROGEN MUS 

TARD.] Cas. lek. cesk., 1950, 89: 534-536. 


3_:No. 6955. The substance of this article is 

essentially the same as that of the author's 

article in: Pol. tygod. lek., 1949, 4: 481- 

487.



131 


BIS-(0-CHLORO-, â€”¿ THERAPY (Continued) 

2256 , 

Aleksandrowicz, J. O NOWYCH WtASCIWOSCIACH 

DWUCHLORO-DWUETYLOMETYLAMINY. I. [ON NEW 

PROPERTIES OF NITROGEN MUSTARD. I.] Polski 

tygod. lek., 1948, 3: 298-300. Nitrogen 

mustard was adminisTered to 9 patients 

with various tumors. Detailed results in 

one case of cancer of the penis are given. 

2257 Aleksandrowicz. J. VALEUR THÃ‰RAPEUTIQUE DE LA 

BICHLORO-BIETHYLOMETHYLAMINE A LA LUMIÃˆRE D'UNE 

ANNÃ‰E D'OBSERVATIONS. [THERAPEUTIC VALUE 0F 

NITROGEN MUSTARD IN THE LIGHT OF OBSERVATIONS 

IN THE COURSE OF ONE YEAR.] Sang, Par., 1948, 

19: 388-402. 25 reÃs. Abstracted In: Index 

ana 1y t. cancer., Par., 1950, 21: No. 73. 

Nitrogen mustard in 0.1 mg. doses was adminis 

tered intravenously to 120 patients with vari 

ous blood diseases and malignant tumors. The 

drug had an irritating influence on the reticulo-endothelial 

system, chiefly manifested 

by ulcerization of the skin around the tumors. 

No toxic side effects were observed. -Index 

analyt. 

2258 

Aleksandrowicz, J., Blicharski, J. and 

Kowalczykowa, J. NOWE MOZLIWOSCI 

LECZENIA NITROGRANULOGENEM. [NEW POSSI 

BILITIES OF NITROGEN MUSTARD TREATMENTS.] 

Polski tygod. lek., 1949, 4: 481-487. 

A review of results obtained with nitro 

gen mustard (2-chloro-2-ethylmethylamine) 

treatment in various diseases, with a de 

tailed report of one case history of 

Hodgkin's disease. The patient(female) 

received 

the drug 

60 mg. 

showed 

of nitrogen mustard, but 

no anti-mitotic effects. 

2259 

Alpert, L. K. RECENT ADVANCES IN THE TREATMENT 

OF THE MALIGNANT DISEASES OF THE BLOOD-FORMING 

ORGANS. Cancer Bull., Wash., 1949, 2: 9-12. 

3 refs. A short review. 

22ft 

pert, L. K. and Peterson, S. S. THE USE OF 

NITROGENMUSTARDIN THE TREATMENTOF LYMPHO- 

MATA. Bull. U. S. Army M. Dep., 1947, 7: 

187-194. 10 refs. 

Alpert, L. K. , Greenspan, E. M. and Peterson, 

S. S. THE TREATMENTOF THE LYMPH01Ã•AS AND OTHER 

NEOPLASTIC DISEASES WITH NITROGENMUSTARD. Ann. 

Int. M., 1950, 32; 393-432. 10 refs. 

2262 

Altana, G. and Lodi. A. MODIFICAZIONI EMATOMI- 

DOLLARI IN CORSO Ã“ITERAPIA CON IPRITE AZOTATA. 

[HEMATOMYELOID MODIFICATIONS IN THE COURSE OF 

NITROGEN MUSTARD TREATMENT.] Gior. clin, med., 

1949, 30: 1024-9. 3 tables, 14 refs. Five 

cases Ã–T Hodgkin's disease, 1 case of myeloid 

leukemia and 3 cases of various tumors treated 

with nitrogen mustard are reported. 

2263 

Anderman, L. B., Johnson, W. M. and Hosmer, F. 

DYSGERMINOMA TREATED WITH NITROGEN 

Am. J. Obst., 1952, 63: 464-466. 

MUSTARD. 

2264 Andersen, B. J. and Ergebner-Mortensen. K. 

BEHANDLINGEN AF LYMFOGRANULOMATOSEMED 

KVAELSTOFSENNEPSGAS. [TREATMENT OF LYMPHO- 

GRANULOMATOSIS WITH NITROGEN MUSTARD.] 

Nord, med., 1948, 37: 87. 

2265 

Anderson, H. E., Bisgard, J. D. and Greene, A. M. 

METASTÃ•TIC CHÃ“RIONEPITRELIOMA OF LUNG WITH 

NITROGEN MUSTARD THERAPY; PRELIMINARY REPORT. 

A.M.A. Arch. Surg., 1954, 68: 829-837. 6 refs. 

"Our report describes a case of choriocarcinoma 

which had presumably left the original 

host(uterus) and had metastasized to the left 

lung...To our knowledge the use of nitrogen 

mustard therapy in the treatment of either 

primary or metastatic choriocarcinoma has not 

been previously reported. From the dramatic 

response observed in our case, it would seem 

that further trial in the use of nitrogen 

mustard in the treatment of this bizarre fetal 

neoplasm is justified." 

2266 

Andreoni, O. and Pisani, G. STUDIO DEL COMPOR 

TAMENTO CLÃ•NICO E DELLE MODIFICAZIONI MORFO- 

LOGICHE E CHIMICHE EMATOMIDOLLARI DI ALCUNE 

AFFEZIONI NEOPLASTICHE IN SEGUITO ALLA SOM 

MINISTRAZIONE DE METIL-BIS-BETA-CLOROETIL- 

AMINO-CLORIDHATO. [STUDY OF THE CLINICAL 

PICTURE AND OF THE MORPHOLOGICAL AND CHEMI 

CAL HEMATO-MEDULLARY CHANGES IN SOME NEO 

PLASTIC DISEASES FOLLOWING ADMINISTRATION OF 

METHYL-BIS-BETA-CHLOROETHYLAMINE HYDROCHLO- 

RIDE.l Arch. sci. med., Tor., 1950, 90: 


med., Sect. 2, 1951, 4: No. 7008. 

2267 

An-tunes Leal, J. and Silva Xavier, A. ACCÃ„O 

DO CLORIDRÃ„TO METIL-BIS ((S-CLORO-ETIL-AMINA) 

EM,DOENCA DE HODGKIN E LEUCEMIA MIELOIDE 

CRONICA. [THE EFFECT OF METHYL-BIS-/I-CHLORO- 

ETHYLAMINE IN HODGKIN'Â§ DISEASE AND CHRONIC 

MYELOID LEUKEMIA.] Clin, contemp., Lisb., 

1947, 2: 989-997. 4 refs. 

2268 

Ap Thomas, I. NITROGEN MUSTARD THERAPY. Proc. 

R. Soc. M., Lond., 1948, 41: 47. Summary of 

results obtained in 

Hodgkin's disease. 

treatment of 27 casÂ«s of 

2269 

Apthomas, M. I. R. and Cullumbine, H. NITROGEN 

MUSTARDS IN HODGKIN'S DISEASE. Lancet, Lond., 


Biol. IBstr., Bait., 1949, 23: No. 3789. 

2270 Ariel, I. M. and Kanter, L. NITROGEN MUSTARD 

THERAPY. CLINICAL STUDIES ON THE EFFECTS OF 

METHYL-BIS (BETA-CHLOROETHYL) AMINE HYDRO- 

CHLORIDE 

DISEASE. 

UPON VARIOUS 

Am. J. Surg., 

TYPES OF NEOPLASTIC 

1949, 77: 509-521. 

6 refs. 

2271 Arons, I. and Freeman, J. W. THE USE OF NITRO 

GEN MUSTARD IN CONJUNCTION WITH RADIATION IN 

THE TREATMENT OF MALIGNANT NEOPLASMS. 

Hosp. Bull., N. T., 1954, li:168-180. 

Harlem 

32 case histories. 

2272 

Ayers, W. B. NITROGEN MUSTARD IN THE TREATMENT 

OF ADVANCED CARCINOMA OF THE LUNG. ANALYSIS 

OF 68 CASES. 

103: 290-294. 

N. Orleans 

16 refs. 

M. k s J., 1951, 


mÃ«3., Sect. 2, 1952, 5: No. 608. 

2273 Bacq, Z. M., Firket, J. and HervÃ©, A. LES DERIVES 

DE L'YPÃ‰RITE EN THÃ‰RAPEUTIQUE. [THE DERIVATIVES 

OF NITROGEN MUSTARD IN THERAPY.] 

mÃ©d. Belgique, 1947, 12: 6 ser., 

Bull. 

295-338, 

Acad. 

33 

i .-is. 7 pi. Twenty-one cases. 

2274 Barenghi, G. and Barisone, D. SUL TRATTAMENTO 

DI ALCUNE EMOPATIE CON CLOROETILAMINE [ON 

THE TREATMENT OF BLOOD DISEASES WITH CHLORO- 

ETHYLAMINES]. Accad. Med., Tor., 1948, 63: 

603-620. Digest in: Minerva Med., Tor ,â€” 

2874* 

Barron, E. S. G. LAS ALKILAMINAS EN EL TRATAMIENTO 

DE LA ENFERMEDAD DE HODGKIN. [ALKYLAMINES 

THE TREATMENT OF HODGKIN'S DISEASE]. Cae. 

IN 

med. 

Lima, 1946, 2: 333-335. 

2275 Bastagli, D. SULL'AZIONE DELLE CLORALCHILAMINE 

(COMPORTAMENTO DI ALCUNIDATIEMATOLOGIÂ« ) . 

[EFFECTSOFCHLOROALKYLAMINE ONBLOOD]. 

Minerva med., Tor., 1950, 41: pt. l, 751-756 

20 refs.



NITROGEN MUSTARDS. ETHYLAKINE, METHYL 


2276 

Bateman, J. C., Klopp, C. T. and Cromer, J. K. 

HEMATOLOGIC EFFECTS OF REGIONAL NITROGEN 

THERAPY. Blood, Bait., 1951, 6: 26-38. 

16 rets. 

2277 

Bauer, R. D. and Erf, L. A. THE CLINICAL EF 

FECT 

DISEASES. 

OF NITROGEN 

Am. J. 

MUSTARD 

M. Sc., 

ON 

1950, 

NEOPLASTIC 

'Â¿19:16-26. 

30 refs. 

2278 

Ben-Asher, S. NITROGEN MUSTARD THERAPY; THE USE 

OF METHYL BIS (/ÃŽ-CHLOROETHYL) AMINE HYDROCHLO- 

RIDE IN HODGKIN'S DISEASE, LEUKEMIA, LYMPHO- 

SARCOMA AND CANCER OF THE LUNG. 

1949, 217: 162-168. 5 reÃs. 

Am. J. M. Sc., 

2279 

Benda, R. and Aubin, H. LA MOUTARDE X L'AZOTE 

DANS LES CANCERS BRONCHO-PULMONAIRES(30 CAS). 

[NITROGEN MUSTARD IN BRONCHOPULMONARYCANCERS 

(30 CASES).] Bull. 

1950, 66: 1376-82. 

Soc. mÃ©d. h6p. 

18 refs. 

Paris, 

2280 

Benda, R., Aubin, H., Franchel, F., Orinstein, 

E. and Betourne, C. 

X L'AZOTE DANS SEPT 

EMPLOI DE LA MOUTARDE 

CAS DE CANCERS BRONCHO- 

PULMONAIRES. 

SEVEN CASES 

[USE OF NITROGEN MUSTARD IN 

OF BRONCHO-PULMONARY CANCER.] 

Bull. Soc. mÃ©d. hop. Paris, 1948, 64: 593- 

598. 9 refs. Four out of seven cases of 

inoperable broncho-pulmonary cancer res 

ponded to treatment with methyl-bis-(2- 

chloroethyl)amine hydrochloride in doses 

of 5 mg usually given every two days and 

injected intravenously in a solution of 5 cc 

of physiologic serum. There was improve 

ment of general condition and the radio 

gram showed regression of pathological 

shadows. 

2281 

Bethell, F. H. , Andrews, G. A., Neligh, R. B. 

and Meyers, M. C. TREATMENT OF HODGKIN'S 

DISEASE WITH ROENTGEN IRRADIATION AND NITRO 

GEN MUSTARDS. Am. J. Roentg., 1950, 64: 61- 

74. 17 refs. 

2282 

Bierman, H. R., Byron, R. L., Jr. and Kelly, 

K. H. HEPATIC ARTERIOGRAPHY AND THE EFFECT 

OF INTRA-ARTERIAL CHEMOTHERAPEUTIC AGENTS ON 

METASTIC NEOPLASMS OF THE LIVER. Am. J. Med., 

1951, 11_: 625. 

2283 

Bierman, H. R., Kelly, K. H., Byron, R. L., Jr., 

Dod, K. S. and Shimkin, M. B. STUDIES ON 

THE BLOOD SUPPLY OF TUMORS IN MAN. II. INTRA- 

ARTERIAL 

LESIONS. 

NITROGEN MUSTARD THERAPY OF CUTANEOUS 

J. Nat. Cancer Inst., 1951, 11.: 891- 

905. 4 pi. 9 refs. 

2284 

Bierman, H. R., Shimkin, M. B., Mettier, S. R., 

Weaver, J., Berry, W. C. and Wise, S. P., III. 

METHYLBIS(BETA-CHLOROETHYL)AMINE IN LARGE 

DOSES IN THE TREATMENT OF NEOPLASTIC DISEASES. 

California M., 1949, n: 117-125. 25 refs. 

2285 

Bierman, H. R., Strait, L. A. and Hrenoff, M. K. 

EXCRETION OF URINARY COPROPORPHYRINS IN PATIENTS 

WITH NEOPLASTIC DISEASES TREATED WITH METHYL- 

BIS (f -CHLOROETHYL)AMINE HYDROCHLORIDE (HN2). 

J. Nat. Cancer Inst., 1949, 10^: 93-103. 14 refs. 

2286 Binazzi, M. AZIONE DELLA AZOTO-IPRITE (NITRO 

GEN MUSTARD) PER INFILTRAZIONE LOCALE IN 

ALCUNE NEOPLASIE DELLA CUTE. [ACTION OF 

NITROGEN MUSTARD BY LOCAL INFILTRATION IN 

SOME NEOPLASMS OF THE SKIN.] Tumori, Milano, 

1950, 24: 374-401. Approx. 40 refs. 


5: No. 2947. 

2287 

Bisaro, A. and Butto, M. EFFETTI TERAPEUTICI 

DELLE AZOTOIPRITI. [THERAPEUTIC EFFECTS OF 

NITROGEN MUSTARDS (CHLORAMINE SIMES).] 

Frulli med., 1950, 5: 351-402. Approx. 40 

refs. Twenty-three~case histories are dis 

cussed. 

2288 

Blain, A., Ill, and NÃ¼rnberger, C. E. NITROGEN 

MUSTARD THERAPY FOR MALIGNANT TUMORS; WITH 

PARTICULAR REFERENCE TO TUMORS OF EPITHELIAL 

ORIGIN. Bull. Alexander 

7: 43-51. 7 refs. 

Blain Hosp , 1948, 

2289 

Block, M. and Murphy, J. C. EFFECT OF NITRO 

GEN MUSTARD IN MYCOSIS FUNGOIDES. 

Chic., 1948, 46: 519-528. 2 pi. 

Arch. Path., 

11 refs. 

Detailed microscopic observations made before, 

during and after treatment with methyl-bis 

(lÃ¬ -chloroethyl)amine hydrochloride are 

presented. 

2290 

Block, M., Spurr, C. L., Jacobson, L. O. and 

Smith, T. R. HISTOPATHOLOGIC EFFECTS OF 

NITROGEN MUSTARD THERAPY UPON NORMAL AND 

NEOPLASTIC HEMATOPOIETIC TISSUES. Am. 

Clin. Path., 1948, 18: 671-689. 4 pi. 

J. 

25 refs. AbstracteuTin: Biol. Abstr., 

Bait., 1949, 23: No. 7221. 

2291 

Bollinelli, R., Bollinelli, R., Denard, [Y.] and 

Serena. UNE SERIE DE MALADIES DE HODGKIN 

TRAITEES PAR LA GAZ MOUTARDE. 

THERAPY OF HODGKIN'S DISEASE]. 

[MUSTARD GAS 

Toulouse mÃ©d., 

1952, 53: 401-414. 2 pi. 

2292 

Bonner, C. D., Thurman, A. and Homburger, F 

A CRITICAL STUDY OF REGIONAL INTRA-ARTERIAL 

NITROGEN MUSTARD THERAPY IN CANCER 

Surg., 1952, 136: 912-918. 7 refs. 

Ann 

2293 

Sonora, O. LA TERAPIA CON AZOTOIPRITE; CON 

TRIBUTO CLÃ•NICO. [THERAPEUTIC USE OF NITRO 

GEN MUSTARDS; CLINICAL OBSERVATIONS]. 

FriuH mod., 1951, 6; 593-607. 24 refs. 

2294 

Borsetto, P. L. and Fazzi, P. L. CONSIDERAZIONI 

SU ALCUNI CASI DI LINFOGRANULOMA MALIGNO 

TRATTATI CON CLORIDRATO DI METIL-BIS(BETA- 

CLOROETIDAMINA. [FINDINGS IN MALIGNANT LYM- 

PHOGRANULOMA TREATED WITH METHYL-BIS( fÃ¬> -CHLORO 

ETHYL) AMINE .] Gazz. med. ital., 1949, 

235-238. 29 refs. 5 case histories. 

108: 

2295 

Bortz, D. W. and Haden, R. L. NITROGEN MUS 

TARD THERAPY; REPORT OF 16 CASES THUS TREAT 

ED. Cleveland Clin. Q., 1947, 14: 218-229. 

8 refs. 

2296 

Bortz, D. W. and Haden, R, L. POLYCYTHEMIA 

VERA RUBRA TREATED WITH NITROGEN MUSTARD; 

REPORT OF A CASE. 

15: 54-55. 1 rÃ©f. 

Cleveland Clin. Q., 1948, 

Botsztejn, C. VORLAUFIGE ERFAHRUNGEN MIT NITRO 

GEN-MUSTARD (METHYL-BIS- /J-CHLORO-AETHYLAMIN) 

BEI LYMPHOGRANULOM.LYMPHOSARKOMUND CHRON. 

LYMPHATISCHER LEUKÃ„MIE. [PRELIMINARY RESULTS 

OF NITROGEN MUSTARD (METHYL-BIS-/3-CHLORO- 

ETHYLAMINE) TREATMENT OF LYMPHOGRANULOMA, 

LYMPHOSARCOMAAND CHRONIC LYMPHATIC LEUKEMIA.] 

Praxis, Bern, 1948, 37: 408-411.



133 


BIS-W-CHLORO-, â€”¿ THERAPY (Continued) 

2298 

Brown, A. and Davis, L. J. NITROGEN MUSTARD 

THERAPY IN RETICULOSES AND PULMONARY NEO 

PLASM; A REPORT ON 

1949, 30: 197-215. 

44 CASES. Glasgow M. J., 

1 pi. 11 refs. Results 

are summarized of nitrogen mustard in 16 

cases of Hodgkin's disease, 12 cases of vari 

ous other disorders of the reticulo-endothelial 

system and 16 cases of pulmonary neo 

plasm. It was concluded that nitrogen mus 

tard should not be regarded as an adequate 

substitute for radiotherapy. 

2299 

Cade, S. CHEMOTHERAPY IN THE TREATMENT OF MALIG 

NANT DISEASE. Brit. M. J., 1949, 2: 1193-1196. 

12 refs. 

2300 

Callebaut, C.-M. and Enderle, J. UN CAS DE 

RET.ICULÃ‡-ENDOTHÃ‰'LIOSECUTANÃ‰ET GANGLIONNAIRE 

AMELIORE PAR LE CHLORHYDRATE DE MÃ‰THYL-BIS- 

BÃŠTA-CHLORÃ‰THYLAMINE. [A CASE OF RETICULO- 

ENDOTHELIOSIS OF THE SKIN AND LYMPH NODES IM 

PROVED BY METHYL-BIS-BETA-CHLOROETHYLAMINE 

HYDROCHLORIDE.] Acta clin, belg., 1952, 7: 

81-87. 7 refs. 

2301 Castex, M. R., Pavlovsky, A. and Pandra, J. 

USO TERAPÃÛTICO DE LAS MOSTAZAS NITROGENADAS. 

[THERAPEUTIC 

Medicina, B. 

APPLICATION 

Air., 1948, 

OF NITROGEN 

8_: 93-104. 

MUSTARDS.] 

13 refs. 

English summary. Treatment of 7 cases of 

Hodgkin's disease, 3 of chronic myelogenous 

leukemia and 1 of lymphosarcoma is reported. 

2302 Chevallier, P., Bilsky-Pasquier, G8, Christo!, D. 

and Boiron, M. SUR LE TRAITEMENT DE LA MALADIE 

DE HODGKIN PAR LA MOUTARDE A L'AZOTE. [TREAT 

MENT OF HODGKIN'S DISEASE WITH NITROGEN MUSTARD.] 

Sem. hop. Paris, 1954, 30: 774-777. Abstracted 

in: Excerpta raed., Sect7~T.6, 1954, No. 3931. 

2303 

Cicala, V. and Giordano, M. SULL'AZIONE TERA 

PEUTICA DELLA CLORAMINA. [THERAPEUTIC ACTION 

OF METHYL-BIS-( ft-CHLOROETHYL)AMINE.] Minerva 

med., Tor., 1949, 40: pt. 2, 321-322. 

2304 C[lough], P. W. THE THERAPEUTIC USE OF NITROGEN 

MUSTARDS. Ann. Int. M., 1947, 27: 641-645. 

5 refs. An editorial based on TTve articles 

describing the biological action of nitrogen 

mustards. 

2305 

Colarusso, A. 

CLORAMINICA 

and Boni, P. 

("=ÃŽERVAZIONI 

DUE ANNI DI TERAPIA 

CLINICHE SU EMOPATICI 

E NEOPLASTICI). [TWO YEARS OF NITROGEN MUSTARD 

THERAPY (CLINICAL OBSERVATIONS ON CASES OF 

BLOOD AND NEOPLASTIC DISEASES).] Progr. med., 

Nap., 1949, 5: 525-534. 15 refs. 

2306 

Colarusso, A. and Boni, P. PRIMI RILIEVI 

SULL'IMPIEGO CLÃ•NICO DI UN PREPARATO ITALIANO 

DI METIL BIS (ÃŸ-CLOROETIL)AMINA CLORIDRATO. 

[PRELIMINARY REPORTS ON THE CLINICAL USE 

OF AN ITALIAN PREPARATION OF METHYL BIS(/b - 

CHLOROETHYL)AMINE HYDROCHLORIDE.] Progr. med., 

Nap., 1948, 4: 206-208. 8 refs. 

2307 

Colarusso, A. and Boni, P. VALORE CLÃ•NICO DELLA 

TERAPIA CLORAMINICA. [CLINICAL VALUE OF 

METHYL-BIS-(fl-CHLOROETHYL)AMINE THERAPY.] 


2308 

COMBINED STAFF CLINIC. CHEMOTHERAPY OF CANCER. 

Am. J. Med., 1952, 12: 720-731. A review. 

2309 

Cook, W. L., Jr., Seiferth, W. J. and Kastlin, 

G. J. THE USE OF NITROGEN MUSTARD IN MALIGNANT 

DISEASE. Am. Practitioner, 1950, 1: 785-789. 

5 refs. 

2310 Cordiviola, L. A., Bosq, P. and Rosselli, S. 

LINFORGRANULOMATOSIS MALIGNA (HODGKIN) DK 

INICIACIÃ“N CUTÃ€NEA: REMISIONTOTALCON 

TRATAMIENTO COMBINADO RADIOTERAPIA-MOSTAZA 

NITROGENADA. [MALIGNANT LYMPHOGRANULOMA- 

TOSIS(HODGKIN'SDISEASE)WITHCUTANEOUS 

INITIATION:TOTALREMISSIONUNDERCOMBINED 

TREATMENT WITHRADIO-THERAPY ANDNITROGEN 

MUSTARD.] Prensa mÃ©d.argent., 1954, 41: 

522-525. 8 refs. 

2311 

Cornell, V. H. and Blauw, A. S. HISTOPATHOLOGIC 

OBSERVATIONS IN CASES OF HODGKIN'S DISEASE 

TREATED WITH NITROGEN MUSTARD. Am. 

1949, 25: 233-237. 1 pi. 16 refs. 

J. Path., 

Abstracted 


2312 

Craver, 

USE. 

L. F. THE 

Radiology, 

NITROGEN MUSTARDS: 

1948, 50: 486-493. 

CLINICAL 

16 refs. 

2313 

Craver, L. F. RECENTADVANCESIN THE TREATMENT 

OF LYPHOMAS[SIC] AND LEUKEMIAS. Cincinnati 

J. M., 1948, 29: 671-679. Discussion: p. 678- 

679. This is briefer but essentially the same 

as the report in Bull. N. Y. Acad. M., 1948, 

24: 3-26. 

2314 

Craver, L. f. SOME ASPECTS OF THE TREATMENT 

OF HODGKIN'S DISEASE. Cancer, Phila., 1954, 


Sect. 16, 1955, 3: No. 1874. 

2318 

Cromer, J. K., Bateman, J. C., Berry, G. N., 

Kennelly, J. M., Klopp, C. T. and Platt, 

L. I. USE OF INTRA-ARTERIAL NITROGEN MUS 

TARD THERAPY IN THE TREATMENT OF CERVICAL 

AND VAGINAL CANCER. 

6jS: 538-548. 7 refs. 

Am. J. Obst., 1952 

2316 

Cucinotta, U. CONTRIBUTO CLÃ•NICO ALL'IMPIEGO 

DELL'AZOTO-IPRITE NEL TRATTAMENTO DEI TUMORI 

POLMONARI IRRICUPERABILI. [CLINICAL OBSER 

VATIONS ON NITROGEN MUSTARD THERAPY OF IN 

CURABLE PULMONARY TUMORS.] Oncologia, Basel, 

1951-1952, 4: 166-80. 26 refs. Five patients 

with advanced bronchial carcinoma were treat 

ed intravenously with 2.5-5 mg of nitrogen 

mustard daily. Some tumor regression was 

observed as well as improved general condi 

tion. The treatment may not be considered 

curative. 

2317 Cucinotta, U. OSSERVAZIONI CLINICHE SULL'IMPIEGO 

DELL'AZOTOIPRITE. [CLINICAL OBSERVATIONS OF 

THE USE OF NITROGEN MUSTARD.] Riv. pat. clin., 


Excerpta med.. Sect. 16, 1954, 2: No. 3909. 

Observations in 62 cases. 

2318 Dameshek, W., Weisfuse, L. and Stein, T. NITRO 

GEN MUSTARD THERAPY IN HODGKIN'S DISEASE: ANA 

LYSIS 

1949, 

OF 

4: 

FIFTY CONSECUTIVE CASES. 

338-379. 46 refs. 

Blood, Bait., 

2319 

Daneu, V. and Pinna Pintor, P. RELAZIONE SULL'USO 

CLÃ•NICO DELL'AZOIPRITE, CLORAMIN. [REPORT ON 

THE CLINICAL USE OF THE NITROGEN MUSTARD, 

CHLORAMINE.] Minerva med., Tor., 1949, 40: pt. 2, 

317-319.



134 


BIS-W-CHLORO-, â€”¿ THERAPY (Continued) 

2320 

De Landsheere, B. and Otte, P. SIX CAS DE LYM 

PHOGRANULOMATOSE DE PALTAUF-STERNBERG ET DEUX 

AFFECTIONS ANALOGUES TRAITÃ‡S PAR NITROGEN 

MUSTARD, UN DERIVE DE L'YPERITE. [SIX CASES 

0F LYMPHOGRANULOMATOSIS AND TWO SIMILAR 

AFFECTIONS TREATED WITH NITROGEN MUSTARD, A 

MUSTARD GAS DERIVATIVE.] Acta clin, belg., 

1948, 3: 391. 

2321 Desaive, P., Closon, J. and Lavigne, J. LE 

TRAITEMENT DE LA LYMPHOGRANULOMATOSEMALIGNE 

PAR LES INJECTIONS INTRA-ARTERJELLES D'YPE 

RITE Ã€L'AZOTE ET DE CHLORAMPHENICOL. [TREAT 

MENT OF MALIGNANT LYMPHOGRANULOMATOSISWITH 

INTRA-AHTERIAL INJECTIONS OF NITROGEN MUS 

TARDS AND CHLORAMPHENICOL.] Rev. med. LiÃ¨ge, 

1954, 9: 112-120. 14 refs. 

2322 Desaive, [P.], Van Steenacker, G. and HervÃ©, A. 

UN CAS DE MYCOSIS FONGOÃ•DÃ‡TRAITÃ‰ PAR INJEC 

TIONS INTRAVEINEUSES D'YPERITE A L'AZOTE. 

[A CASE OF MYCOSIS FUNGOIDES TREATED WITH 

INTRAVENOUS INJECTIONS OF NITROGEN MUSTARD.] 

Arch. belg. derm, syph., 1948, 4: 226-239. 

5 refs. 

2323 

Deuschle, K. W. and Wiggins, W. S. THE USE OF 

NITROGEN MUSTARD IN THE MANAGEMENT OF TWO 

PREGNANT LYMPHOMA PATIENTS. Blood, Bait., 

1953, 8: 576-579. 

2324 

Dieska. D. "NITROGEN MUSTARD" V LIEÃ–BE NEOPLASTI- 

CKYCH KRVNYCH CHOROB. [NITROGEN MUSTARD IN THE 

TREATMENT OF NEOPLASTIC BLOOD DISEASES.] 

Bratisl. lek. listy, 1947, 27: 615-620. 2 refs. 

The findings in one case of~Tymphogranulomatosis 

and one case of lymphosarcoma treated with nitro 

gen mustard are reported. The drug was imported 

from USA, and used in 0.1 mg doses in from four 

to eight intravenous infusions. The effects 

were similar to those of benzene and irradiation. 

Symptomless remission lasting from several weeks 

to several months followed. 

2325 

Di Pietro, S. and Giacomelli, L. V. LE IPRITI 

AZOTATE E LA CHEMIOTERAPIA DEI TUMORI MALIGNI: 

BASI TEORICHE E APPLICAZIONE CLINICHE. 

TROGEN MUSTARD AND CANCER CHEMOTHERAPY: 

Â¡NI 

THEO 

RETICAL BASIS AND CLINICAL PRACTICE.] Milano, 

Ambrosiana, 1954. 124p. Bibliography: p. 119- 

124. [Suppl. to Tumori, 1954, 40.] 

232o 

Dittrich, H. ERGEBNISSE DER STICKSTOFFLOST - 

BEHANDÂ¿UNG. [NITROGEN MUSTARD THERAPY.] 

Klin. Med., Wien, 1952, 7: 100-106. 24 

refs. 

2327 Eichenlaub, F. J. and Olivo, M. A. NITROGEN 

MUSTARD THERAPY OF LYMPHOSARCOMA; REPORT OF 

A CASE. Med. Ann. District of Columbia, 

1948, 17: 391-394; 428. 6 refs. Treatment 

caused" regression of a large cutaneous le 

sion and recession of the esophageal con 

striction by the neoplastic tissue. Toxic 

reactions, however , hastened death. 

23Ildon, K. OM KVAELSTOF-SENNEPSGASBEHANDLING 

AF POLYCYTHAEMIA IDIOPATHICA. [TREATMENT OF 

POLYCYTHEMIA VERA WITH NITROGEN MUSTARD.] 


English summary. Two case histories. 

Emerick, R. OBSERVATIONS OF NITROGEN MUSTARD 

THERAPY (PRELIMINARY REPORT). Harper Hosp. 

Bull., Detr., 1948, 6: 18-21. 6 refs. 

A brief review. 

2330 

Erf, L. A. and Bauer, R. D. THE CLINICAL EFFECT 

OF NITROGEN MUSTARD ON HODGKIN'S DISEASE. 

Am. J. Clin. Path., 1949, 19: 372-380. 20 refs. 

Abstracted in: Biol. Abstr., Bait., 1950. 24: 

No. 4122. 

2331 

Faloon, W. W. and Gorham, L. W. CLINICAL EX 

PERIENCE WITH NITROGEN 

State J. M., 1948, 48: 

MUSTARD. 

612-616. 

N. York 

10 refs. 

The chemical and biological actions of the 

mustard compounds are reviewed and the re 

sults obtained with their use in 15 cases 

of neoplastic diseases are described. 

2332 

Farber, S. CHEMOTHERAPEUTIC STUDIES OF TUMORS 

INCLUDING LEUKEMIA, IN CHILDREN. 

Child., 1950, 79: 961-962. 

Am. J. Dis. 

2333 

Fellinger, K. and Reimer, E. NITROGEN MUSTARD 

IN DER INTERNEN KLINIK. [NITROGEN MUSTARD IN 

INTERNAL DISEASES.] Wien. klin. 

61: 681-684. Approx. 25 refs. 

Wschr., 1949, 

2334 Ferrara, A. I QUADRI ISTOMORFOLOGICI DEL LIN 

FOGRANULOMA MALIGNO TRATTATO. [HISTOLOGICAL 

PICTURE IN TREATED CASES OF MALIGNANT LYM- 

PHOGRANULOMA.] Arch. ital. anat. pat., 1954 

27: 492-529. Approx. 75 refs. English 

summary. 

235 Ferrari, M. and Penco, N. ENSAYOS CLÃ•NICOS CON 

LAS MOSTAZAS NITROGENADAS. [CLINICAL EXPERI 

MENTS WITH NITROGEN MUSTARDS.] Arch. urug. 

med., 1949, 35: 26-41. 7 refs. Tables. 


2336 French, J. D., West, P. M., von Amerongen, T. K 

and Magoun, H. W. EFFECTS OF INTRACAROTID 

ADMINISTRATION OF NITROGEN MUSTARD ON NORMAL 

BRAIN AND BRAIN TUMORS. J. Neurosurg., 1952, 

9: 378-389. 11 refs. 

2337 Frisk, A. R. and Hultberg, S. KVAVESENAPSGAS- 

BEHANDLING AV LYMFOGRANULOMATOSIS MALIGNA. 

[TREATMENT OF LYMPHOGRANULOMA WITH NITROGEN 

MUSTARD.] Sven, laktidn., 1948, 45: 685. 

5 refs. 15 case histories. 

[2338 not used] 

2339 Gaensler, E. A., McKay, D. G., Ware, P. F. and 

Lynch, J. P. CYTOLOGIC CHANGES IN BRONCHO- 

GENIC CARCINOMA FOLLOWING TREATMENT WITH 

NITROGEN MUSTARD (METHYL-BIS-[/J -CHLOROETHYL] 

AMINE). Arch. Path., 1948, 46: 503-518. 


43: 7135b. 

2340 

Gandola, M. PRIMO TENTATIVO DI CURA DELLA 

MICOSI FUNGOIDE CON IL CLORIDRATO DI DICLORO- 

ETIL-METIL-AMINA (NITROGEN MUSTARD). [FIRST 

ATTEMPT TO TREAT MYCOSIS FUNGOIDES WITH HY- 

DROCHLORIDE OF METHYL-BIS- f>-CHLOROETHYL AM INE .] 


2341 Gardini, G. F. and Tori, G. L'IPRITE AZOTATA 

NELLA TERAPIA DEI TUMORI. [THE NITROGEN- 

MUSTARDIN TUMORTHERAPY.] Oncologia, Roma, 


Excerpta med., Sect. 5, 1949, 2: No. 2884.



135 


BIS-(f3-CHLORO-, â€”¿ THERAPY (Continued) 

2342 

Gaukhman, S. L. and Berger. R. G. LECHENIE 

LEIKOZOV EMBIKHINOM. [TREATMENT OF LEUKEMIAS 

WITH E1IBIKHIN.] Klin. med. , Moskva., 1951, 

29: No. 8, 50-54. 

Ã¯Ã¢~rd,administered 

Embikhin, a nitrogen musto 

11 patients with chronic 

myelosis reduced the leucocyte count and im 

proved the overall condition of the patients. 

Embikhin should be given in conjunction with 

blood transfusions. Best results are achieved 

in patients refractory to urethane and X-ray 

treatment. 

2343 Gautier, A. LES TRAITEMENTS PAR LE "NITROGEN 

MUSTARD" SPÃ‰CIALEMENTDU LYMPHOGRANULOME. 

[NITROGEN MUSTARD THERAPY ESPECIALLY IN 

HODGKIN'S DISEASE]. Praxis, Bern, 1947, 

36: 590-591. A discussion. 

2344 Gellhorn, A. and Collins, V. P. A QUANTITATIVE 

EVALUATION OF THE CONTRIBUTION OF NITROGEN 

MUSTARD TO THE THERAPEUTIC MANAGEMENT OF 

HODGKIN'S DISEASE. Ann. Int. M 1951, 35: 

1250-1259. 2 refs. The course of the disease 

was compared in two groups of patients: 67 

patients who received radiation and nitrogen 

mustard and 65 patients who received radio 

therapy alone. 

2345 Gianotti, F. and Levi, L. EFFICACIA TERAPEUTICA 

DELL'AZOTOIPRITE IN UN CASO DI LEUCEMIA LIN 

FATICA CRONICA CON LEUCEMIDE CUTANEA DIFFUSA. 

[THERAPEUTIC EFFICACY OF NITROGEN MUSTARD IN 

A CASE OF CHRONIC LYMPHATIC LEUKEMIA WITH 

DIFFUSE CUTANEOUS LEUKEMIA.] Gior. ital. 

derm, sii., 1951, 92: 179-187. 2 pi. 10 refs. 

2346 

Gigli, G. AFFEZIONI LINFOGHIANDOLARI TRATTATE 

COL METIL-BIS-BETA-CLOROETIL-AMINA CLORIDRATO 

(CLORAMIN SIMES) SEGUITO DA IRRADIAZIONI 

ROENTGEN. [LYMPHOGLANDULARDISEASES TREATED 

WITH METHYL-BIS-0-CHLOROETHYLAMINE HYDRO- 

CHLORIDE (SIMES' CHLORAMINE) FOLLOWED BY 

ROENTGEN IRRADIATIONS.] 

1949, 40: pt. 2, 300-302. 

Minerva med., Tor., 

2347 (-,iImÃ¡n,A. and Phillips, F. S. THE BIOLOGICAL 

ACTIONS AND THERAPEUTIC APPLICATIONS OF THE 

P -CHLOROETHYL AMINES AND SULFIDES. Science, 

1946, 103: 409-415, 436. 68 refs. 

2348 Giordano, F. and Raddi, R. TRATTAMENTO CLORO- 

AMINICO IN CASI ACUTI E CRONICI DI LEUCEMIA. 

[TREATMENT WITH CHLORAMINES OF ACUTE AND 

CHRONIC CASES OF LEUKEMIA.] Riforma med., 

1952, 66: 1241-1248. 39 refs. 

2349 

Goldberg, L. C. and Mason, L. M. THE TREATMENT 

OF CUTANEOUS BLASTOMAS AND OTHER DISEASES 

WITH NITROGEN MUSTARD. Arch. Derm. 

Chic., 1949, 60: 181-189. 7 refs. 

Syph., 

2350 Goldeck, H. DIE STICKSTOFF-LOST-BEHANDLUNG DER 

HAEMOBLASTOSEN. [NITROGEN-MUSTARD TREATMENT 

OF HEMOBLASTOSES.] Aerztl. Forsch., 1949, 

3: Originalarb., 39O-4OO. 

2351 Goldman, R., Egeberg, R. O., Ware, E. R., Evans, 

E. R. and Fishkin, B. G. CLINICAL EXPERIENCE 

WITH NITROGEN MUSTARD THERAPY. Arch. Int. M., 

1948, 82: 125-139. Results observed in treat 

ment oT~~40 male patients, who had Hodgkin's 

disease, lymphosarcoma, leukemia and related 

diseases. 

2352 Goodman, L. S., Wintrobe, M. M., Dameshek, W., 

Goodman, M. J., Oilman, A. and McLennan, M. T. 

NITROGEN MUSTARD THERAPY. USE OF METHYL-BIS 

(A -CHLOROETHYL)AMINE HYDROCHLRIDE AND TRIS 

(/ÃŽ-CHLOROETHYL)AMINE HYDRCCHLORIDE FOR HODGKIN'S 

DISEASE, LYMPHOSARCOMA, LEUKEMIA AND CERTAIN 

ALLIED AND MISCELLANEOUS DISORDERS. J. Am. M. 

Ass., 1946, 132: 126-132. In an impressive 

proportion oÃterminal and radiation 

cases (67), the/? -chloroethylamines 

resistant 

produced 

clinical remissions lasting from weeks to 

months. 

2353 

Goodman, L. S., Wintrobe, M. M., McLennan, M. T., 

Dameshek, W., Goodman, M. J. and Oilman, AÂ« 

USE OF METHYL-BIS (/a-CHLOROETHYL) AMINE HYDRO- 

CHLORIDE 

CHLORIDE 

AND TRISC4 -CHLOROETHYDAMINE 

("NITROGEN-MUSTARDS") IN THE 

HYDRO- 

THERAPY 

OF HODGKIN'S DISEASE, LYMPHOSARCOMA, LEUKEMIA 

AND CERTAIN ALLIED AND MISCELLANEOUS DISOR 

DERS. 

Wash., 

In: APPROACHES TO TUMOR CHEMOTHERAPY. 

Am. Ass. Advance. Sc., 1947, p. 338- 

346. 5 refs. 

2354 

Grady, E. D., Krantz, S. and Brown, P. F. 

TREATMENT OF CANCER BY INTERMITTENT INJECTION 

OF NITROGEN 

Ann. Surg., 

MUSTARD VIA CANNULATED 

1953, 137; 366-374. 

ARTERIES. 

2355 Graulich, W. OBER DIE STICKSTOFF-LOST-BEHAND- 

LUNG DER MALIGNEN TUMOREN. [NITROGEN MUS 

TARD THERAPY OF MALIGNANT TUMORS] . 

Strahlentherapie, 1950, 82: 95-114. 26 refs. 

2356 

Greenwalt, T. J. and Grueninger, A. J. CLINICAL 

OBSERVATIONS WITH METHYL-BIS (A -CHLOROETHYL) 

AMINE HYDRCCHLORIDE. J. Laboral. Clin. M., 

1948, 3j3: 1648-1649. 

2357 

Groen, J., Godfried, E. G., Kromsigt, G. K. L., 

Reisel, J. H. and Tillema, S. BEHANDELING 

VAN LYMPHOGRANULOMA MALIGNUM EN VERWANTE TOE- 

STANDEN MET METHYL-BIS-CHLORAETHYLAMINE 

("NITROGEN MUSTARD"). [TREATMENT OF MALIG 

NANT LYMPHOGRANULOMA AND RELATED DISEASES 

WITH NITROGEN MUSTARD.] Ned. tschr. geneesk., 

1949, 93: 2081-2689. 2 pi. English summary. 

Survey~of the literature and report of the 

author's experience. Indications, technique 

of treatment, control measures and results 

are described. 

2358 

Guglielmo, G. di CONCLUSIONI RIASSUNTIVE SUL 

TRATTAMENTO IN ITALIA DI 

AZOIPRITI E COLL'URETANO. 

VARIE EMOPATIE 

[SUMMARIZING 

COLLE 

CON 

CLUSIONS ON THE TREATMENT IN ITALY OF VARIOUS 

[MALIGNANT] BLOOD DISEASES WITH NITROGEN MUS 

TARD AND URETHANE.] 

4Â£: pt. 2, 277-279. 

Minerva med., Tor., 1949, 

2359 Heim, W. ERFOLGREICHE BEEINFLUSSUNG MULTIPLER 

AUSGEDEHNTER HAUTMETASTASEN EINES MAMMA-CARCI- 

NOMS DURCH DICHLOREN. [SUCESSFUL TREATMENT 

OF MULTIPLE EXTENSIVE CUTANEOUS METASTASES 

OF MAMMARY CANCER BY NITROGEN MUSTARD.] 

med. Zschr., 1950, 1.:370-374. 

Beri, 

2360 

Heim, W. ZUR BEHANDLUNG DES INOPERABLEN KARZI 

NOMS. [ON THE TREATMENT OF INOPERABLE CANCER.) 

Deut. med. Wschr., 1952, 77: 724. This is an 

abstract of the author's TÃ«Tcturedelivered at 

the conference of the Berlin medical society 

on July 25, 1951. Following a brief discussion 

on radiotreatment, hormonal and isotope therapy, 

the chemotherapy of cancer is surveyed. Of 

the chloroethylamines dichloren was used most 

extensively. 

2361 Henstell, H. H. and Tober, J. N. TREATMENT OF 

MYCOSIS FUNGOIDES WITH NITROGEN MUSTARD. 

J. Invest. Derm., 1947, 8: 183-188. 4 refs.



136 



2362 

Henstell, H. H., Tober, J. N. and Newman, B. A. 

THE INFLUENCE OF NITROGEN MUSTARD ON MYCOSIS 

FUNGOIDES; OBSERVATIONS RELATING ITS EFFECT 

TO THE RETICULO-ENDOTHELIAL SYSTEM. Blood, 

1947, 2: 564-577. 8 refs. Six patients. 

2363 

Herraiz, T. R. and Colombo, O. R. CARCINOMAS 

PELVIANOS TRATADOS CON GAS MOSTAZA POR VIA 

INTRAARTERIAL. [PELVIC CARCINOMA TREATED 

BY. INTRA-ARTERIAL NITROGEN MUSTARDS.] DÃ•a 

med., B. Air., 1954, 26: 757-759. 6 refs. 

2364 HervÃ©, A. LES DÃ‰RIVESDE L'YPÃ‰RITE EN CANCÃ‰RO 

LOGIE. [THE DERIVATIVES OF NITROGEN MUSTARD 

IN CANCER STUDY.] Acta clin, belg., 1948, 3: 

419-439. 12 refs. 

2365 HervÃ©, A. POSSIBILITES D'AVENIR DES TRAITEMENTS 

PAR L'YPÃ‰RITE ET LES ISOTOPES RADIO-ACTIFS. 

[FUTURE POSSIBILITIES OF THERAPY WITH NITROGEN 

MUSTARDS AND RADIOACTIVE ISOTOPES.] Rev. med. 

Liege, 1948, 3: 555-562. 5 refs. 

2366 

Hofmeyr, H. 0. CLINICAL EXPERIENCES WITH NITRO 

GEN MUSTARD IN HODGKIN'S DISEASE. S. Afr. M. 

J., 1947, 21: 195-198. Report of 3 cases. 

2367 Ingrassia, G. and Vasile, B. LA TERAPIA AZO- 

IPRITICA DEL GRANULOMAMALIGNO; DELLE LEUCE 

MIE E DELLE NEOPLASIE. [NITROGEN MUSTARD 

THERAPY OF MALIGNANT GRANULOMA, LEUKEMIA 

AND NEOPLASMS.] Haematologica, Pavia, 1951, 

35: 907-953. Approx. 60 refs. English 

summary. Results obtained in 18 cases are 

reported. 

2 Iversen, K. and Kjerulf-Jensen, K. KVAELSTOF- 

SENNEPSGAS VED LYMFOGRANULOMATOSISMALIGNA, 

POLYCYTAEMIA OG MYELOMATOSIS. [TREATMENT 

OF MALIGNANT LYMPHOGRANULOMATOSIS, POLY- 

CYTHEMIA VERA AND MYELOMAWITH NITROGEN 

MUSTARD]. Nord, med., 1948, 38: 1248-1252. 

9 refs. English summary. Treatment of 21 

patients. 

QOgQ 

Iversen, K. and Kjerulf-Jensen, K. SUR LE TRAITE 

MENT DE LA LYMPHOGRANULOMATOSE MALIGNE, DE LA 

POLYCYTHÃ‰MIE VRAIE ET DE LA MYÃ‰LOMATOSE PAR 

L'YPERITE D'AZOTE. [THE TREATMENT OF HODGKIN'S 

DISEASE, POLYCYTHEMIA VERA AND MYELOMATOSIS 

WITH NITROGEN MUSTARD.] Acta clin, belg., 


Index Ã¤nalyt. cancer., Par., 1949, 20: No. 524. 

2370 

Jacobson, L. 0., Spurr, C. L., Barron, E. S. G., 

Smith, T. R., Lushbaugh. C. and Dick, G. F. 

STUDIES ON THE EFFECT OF METHYL BIS (lÃ¬-CHLO- 

ROETHYL)AMINE HYDROCHLORIDE ON DISEASES OF THE 

HEMOPOIETIC SYSTEM. J. Clin. Invest., 1946, 

25: 909-910. An abstract. 

2371 Jacobson, L. O., Spurr, C. L., Smith, T. H. 

and Dick, G. F. RADIOACTIVE PHOSPHORUS (P32) 

AND ALKYLAMINES (NITROGEN MUSTARDS) IN THE 

TREATMENT OF NEOPLASTIC AND ALLIED DISEASES 

OF THE HEMOPOIETIC SYSTEM. Med. Clin. N. 

America, 1947, 3-18. 25 refs. 

2372 

Janbon, mbon, M. and Bertrand, L. LYMPHOSARCOME LEU 

CÃ‰MIQUE (LYMPHOSARCOlÃ¡ATOSE). EFFICACITÃ‰ RE-, 

MARQUABLE MAIS TRANSITOIRE DE L'YPERITE NITREE. 

[LEUCEMIC LYMPHOSARCOMA(LYMPHOSARCOMATOSIS). 

REMARKABLE 

MUSTARD.] 

BUT TRANSITORY EFFECT OF NITROGEN 

Sang, Par., 1949, 20: 491-497. 

6 refs. Abstracted in: Index analyt. cancer., 

Par., 1951, 22: No. 493. 

2373 

Jorns, G. and Paulus, H. J. INTRA-ARTERIELLE 

STICKSTOFFLOST-BEHANDLUNG. [INTRA-ARTERIAL 

THERAPY OF NITROGEN MUSTARD.] Zbl. allg. 

Path., 1954, 92: 81-84. 7 refs. When 

nitrogen mustard was administered intraarterially 

in total doses of 5-30 mg its 

toxic side-effects were reduced and to 

lerance to the drug was increased. The 

blood picture was essentially unchanged 

except for a reduction in the leucocyte 

count. No.phlebitis at the site of the 

injection was noted. 

2374 

Joyeux, R., Courty, A. and Bertrand, L. LYMPHO- 

SARCOMES ILÃ‰O-MÃ‰SENTÃ‰RIQUES;ESSAI DE TRAITE 

MENT PAR L'YPÃ‰RITE NITREE. [ILEOMESENTERIC 

LYMPHOSARCOMAS; TRIAL THERAPY WITH NITROGEN 

MUSTARD.] Sem. hop. Paris, 1951, 27: 1008- 

1011. 7 refs. Three cases. 

2375 

Justin-BesanÃ§on, L. and Lamotte-Barillon, S. 

LE TRAITEMENT DK IA MALADIE DE HODGKIN PAR 

LES DERIVES AZOTES DE L'YPERITE; INDICATIONS, 

TECHNIQUE 

HODGKIN'S 

ET RÃ‰SULTATS. [THE TREATMENT 

DISEASE BY NITROGEN MUSTARDS; 

OF 

IN 

DICATIONS, TECHNIQUE AND RESULTS.] Maroc 

med., 1949, 28: 294-299. Also in: Acquis, 

mÃ©d. rÃë., Par., 1949, 225-240; a briefer 

version 

549-551. 

in: 

A 

Synth, 

biochemical 

sÃ©mÃªi.thÃ©r., 

and clinical 

1949, 

re~ 

3: 

view. 

2376 

Justin-Besancon, L., Lamotte-Barillon, S. and 

Debray, J. REFLEXIONS SUR LE DIAGNOSTIC ET 

LE TRAITEMENT DE LA MALADIE DE HODGKIN; X 

PROPOS DE L'Ã‰TUDE DE 110 MALADES. [DIAGNOSIS 

AND THERAPY OF HODGKIN'S DISEASE; STUDY OF 

110 CASES.] Sem. hOp. Par., 1952, 28: 3855- 

3871. 56 refs. 


Polonovski, C. 

DANS LA MALADIE 

LES DÃ‰RIVÃ‰SAZOTÃ‰S DE L'YPÃ‰RITE 

DE HOGDKIN [SIC] D'APRES 50 

OBSERVATIONS. [NITROGEN MUSTARDS IN HODGKIN'S 

DISEASE; STUDY OF 50 CASES.] Bull. Acad. nat. 

ned., Par., 1949, 133: 148-152. 4 refs. 

2378 Justin-BesanÃ§on, L., Lamotte-Barrillon, S. and 

Polonovski, C. ESSAI DE TRAITEMENT DES MALA 

DIES MALIGNES DU SYSTEME HEMOPOIETIQUE PAR 

LES ANALOGUES DE L'YPÃ‰RITE (MOUTARDES A 

L'AZOTE). [THERAPEUTIC TRIALS WITH MUSTARD 

GAS ANALOGUES (NITROGEN MUSTARDS) IN MALIG 

NANT DISEASES OF THE HEMOPOIETIC SYSTEM.] 

Bull. Soc. med. hop. Paris, 1947, 63: 1031- 

1033. Treatment of 20 patients wiÃ®n"methyl 

bis /3 -chloroethylamine resulted in most 

cases in spectacular clinical results, es 

pecially in cases of Hodgkin's disease, and 

in those resistant to radiotherapy. Toxicity 

and in final analysis mere palliative effects 

of the drug are stressed. 


Polonovski, C. ESSAIS DE NOUVEAUX 

DE L'YPÃ‰RITE (MOUTARDES A L'AZOTE) 

ANALOGUES 

ET DE 

LEURS ANTIDOTES. [TRIAL OF NEW ANALOGUES OF 

MUSTARD GAS (NITROGEN MUSTARDS) AMD THEIR 

ANTIDOTES.] Bull. Soc. mÃ©d. hop. Paris, 

1948, 64: 582-584. Discussion: p. 584-586. 

A brieTÃ«V account of study 

Sem. hop. Paris, 1948, 24: 

reported in: 

1529-1532.



137 


BIS-(/3-CHLORO-, â€”¿ THERAPY (Continued) 


Polonovski, C. Ã‰TUDE CRITIQUE DES RÃ‰SULTATS 

CLINIQUES OBTENUS LORS DU TRAITEMENT DE 40 

CAS D'HÃ‰MOPATHIES MALIGNES PAR LA MOUTARDE 

Ã€L'AZOTE. [CRITICAL STUDY OF CLINICAL 

RESULTS OF NITROGEN MUSTARD TREATMENT OF 

MALIGNANT HEMOPATHIES IN 40 CASES.] Sen. 

hop., Paris, 1948, 24: 1518-1529. 13 reÃs. 

A review of toxic ana" palliative effects 

of methyl-bis-/3-chloroethylamine admini 

stered to 40 patients with various leukeraias. 

Best results were obtained in Hodgkin's 

disease. 

2381 

Justin-Besancon, L., Lamotte-Barillon, S. and 

Polonovski, C. 

TRAITEMENT PAR 

INDICATIONS CLINIQUES DU 

LES ANALOGUES DE L'YPERITE. 

RÃ‰SULTATS QU'ON PEUT EN ATTENDRE; Ã‰TUDE 

BASÃ‰E SUR 40 OBSERVATIONS. [CLINICAL INDI 

CATIONS FOR TREATMENT WITH MUSTARD GAS ANA 

LOGUES. RESULTS TO BE EXPECTED; STUDY BASED 

ON 40 CASES.] Bull. Soc. mÃ©d. hop, Paris, 

1948, 64: 576-582. Report on treatment of 

19 cases of Hodgkin's disease, 9 cases of 

lymphosarcoma and various other hemopathies 

with nitrogen mustard. Improvements are 

considered to be palliative, frequent toxic 

effects are noted, and judicious administra 

tion of drug is advised. 


Polonovski, C. TOLÃ‰RANCE CLINIQUE DES ANA 

LOGUES DE L'YPERITE (MOUTARDES A L'AZOTE); 

Ã‰TUDE BASÃ‰E SUR 40 OBSERVATIONS. [CLINICAL 

TOLERANCE OF MUSTARD GAS ANALOGUES (NITROGEN 

MUSTARDS); STUDY BASED ON 40 CASES.] Bull. 

Soc. mÃ©d. hop. Paris, 1948, 64: 569-576. 

A discussion of: dosage, indÃ¯cations for 

treatment, toxic reactions, methods of re 

duction of toxicity, modifications of the 

hemopoietic system, of the gastric epithe 

lium, and the gonads. 

2383 Juul-Andersen, B. OM BEHANDLINGEN MED KVAELSTOF- 

SENNEPSGAS. [TREATMENT WITH NITROGEN-MUSTARD.] 


2384 

Karnofsky, D. A. CHEMOTHERAPEUTIC DEVELOPMENTS 

ON THE 

No. 2, 

CANCER FRONT. 

4-9. 13 refs. 

Merck Rep., 1952, 60: 

2385 

Karnofsky, D. A. THE NITROGEN MUSTARDS AND 

THEIR APPLICATION IN NEOPLASTIC DISEASES. 

N. York State J. M.., 1947, 47: 992-993. 

7 refs. A short review. 

2386 

Karnofsky, D. A. NITROGEN MUSTARDS IN THE 

TREATMENT OF NEOPLASTIC 

Int. M., 1950, 4: 1-75. 

DISEASE. Advance. 

232 refs. A com 

prehensive review discussing: background, 

chemistry, effects on cells, animals and 

tumors, derivatives, comparison of biologic 

effects of X-rays and nitrogen mustards, 

clinical applications and indications for 

use. 

2387 

Karnofsky, D. A., Abelmann, W. H., Craver, L. F. 

and Burchenal, J. H. THE USE OF THE NITRO 

GEN MUSTARDS IN THE PALLIATIVE TREATMENT OF 

CARCINOMA. WITH PARTICULAR REFERENCE TO BRON- 

CHOGENIC 

634-856. 

CARCINOMA. 

Abstracted 

Cancer, N. Y., 1949, 1: 

in: Biol. Abstr., BalT., 

1949, 23J No. 26541. 

2388 Karnofsky, D. A., Burchenal, J. H. and Escher, 

G. C. CHEMOTHERAPY OF 

Med. Clin. N. America, 

NEOPLASTIC DISEASES. 

1950, 439-458. 53 refs 

2389 

Karnofsky. D. A., Craver, L. F., Rhoads, C. P. 

and Abels, J. C. AN EVALUATION OF METHYL- 

BIS(/Â« -CHLOROETHYL)AMINE HYDROCELORIDE AND 

TRIS(/i -CHLOROETHYL)AMINE HYDROCHLORIDE 

(NITROGEN MUSTARDS) IN THE TREATMENT OF LYM- 

PHOMAS, LEUKEMIA AND ALLIED DISEASES. 

In: APPROACHES TO TUMOR CHEMOTHERAPY. Wash., 

Xm. Ass. Advance. Sc., 1947, p. 319-337. 

3 refs. 

2390 Kauer, G. L., Jr. CANCER OF THE LYMPH NODES. 

Connecticut M. J., 1954, 18: 738-741. 5 refs. 

2391 

Kennedy, B. J. and Aub, J. C. THE THERAPEUTIC 

INDICATIONS FOR NITROGEN MUSTARDS IN LYMPHOMA. 

Med. Clin. N. America, 1949, 1301-1311. 

2392 

Kent, L. and Reh, E. P. TREATMENT OF BRONCHO- 

GENIC CARCINOMA WITH NITROGEN MUSTARD. Dis 

Chest, 1950, 17: 190-201. 19 refs. Results 

of 16 cases sÃ®TTdiedis presented. 

2393 

Kierland, R. R., Watkins, C. H. and Shullenberger, 

C. C. THE USE OF NITROGEN MUSTARD IN THE TREAT 

MENT OF MYCOSIS FUNGOIDES. J. Invest. Derm., 

1947, 9: 195-201. 6 refs. 

2394 

Kimura, K., Maruo, M. and Saito, s. A SUPPLE 

MENTARY NOTE ON THE CHEMOTHERAPY OF LEUKEMIA. 

PART 2. THE INFLUENCES OF CHEMOTHERAPEUTIC 

AGENTS ON BLOOD ADENOSIN TRIPHOSPHORIC ACID 

AND ADENOSIN DIPHOSPHORIC ACID. 

Jap., 1953, 1



138 


BIS-(/3-CHLORO-, â€”¿ THERAPY (Continued) 

2401 

Kreiner, W. M. and Bauer, L. LOST-ANWENDUNG BEI 

KARZINOM. [THE USE OF NITROGEN MUSTARD IN 

CARCINOMA.] Wien. kiln. 

756-759. 18 reÃs. 

Wschr., 1950, 62: 

2402 

Kurnick, N. B., Paley, K. R., Fieber, M. H. 

and Adler, D. K. TREATMENT OF MALIGNANT 

DISEASE KITH NITROGEN MUSTARD. Ann. Int. 

M., 1949, 30: 974-1003. 11 refs. Abstrac 

ted In: Excerpta ned., Sect. 5, 1950, 3: 

No. 778. 

2403 

Larionov, L. F. LECHENIE BELOKROVIÃ•A I LIMFO- 

GRANULEMATOZA EMBIKEINOM. [TREATMENT OF 

LEUKEMIA AND LYMPHOGRANULOMATOSIS WITH EMBIKHIN.] 

Moskva, Izd. Akademii meditsinskikh nauk SSSR, 

1951. 98 p. Reviewed In: Klin, med., Moskva, 

1951, 29: No. 12, 85-86, by Kh. Kh. Vlados. 

The auHTor, recipient oÃ the Stalin prize, 3rd 

grade, introduced a new leukemia therapy by 

using the Russian equivalent of nitrogen mus 

tard, embikhin,on 145 patients with chronic 

myelosis and lymphogranulomatosis. The drug 

in daily doses of 3-7 mg reduced the leucocyte 

count and improved the overall condition of 

the patients. No histological results, or 

negative effects of embikhin are given. 

24Lazarev, N. EMBIKHIN V TERAPII OPUKHOLEVYKH 

ZABOLEVANII. [EMBIKHIN IN THE THERAPY OF 

CANCER.] Med. rabot., 1953, No. 1186, 2. 

Review of 

embikhin. 

reportÂ»given at the conference on 

The drug, one of the chloroethylamine 

group, was tested both experimentally 

and clinically with good results. Embikhin 

inhibits nucleoprotein metabolism in blood 

and cancer tissue. Embikhin No. 7 was most 

effective in lymphogranuloma; excellent 

results were also achieved in cases of chro 

nic leukemia. The toxic side effects can 

be reduced by adhering to proper dosage. 

2405 

Leidel, H. J. ZUR BEHANDLUNG DER MYCOSIS 

FUNGOIDES MIT ZYTOSTATISCHEN STOFFEN. [TREAT 

MENT OF MYCOSIS 

AGENTS.] Derm. 

FUNGOIDES WITH CYTOSTATIC 

Wschr., 1950, 169-177. Approx. 

20 refs. 

2406 Lentini, S. and Polimeni, R. IMMUNITÃ€, PROTIDI 

SIERICI E QUADRO LEUCOCITARIO NEL GRANULOMA 

MALIGNO; AZIONE DELLA TERAPIA CON AZOTO-IPRITI. 

[IMMUNITY, BLOOD PROTEINS AND LEUCOCYTE PIC 

TURE IN MALIGNANT GRANULOMA; EFFECT OF NITRO 

GEN MUSTARDS THERAPY.] Policlinico, sez. med., 


2408 

Leone, H. SU DUE CASI DI MICOSI FUNGOIDE TRAT 

TATI CON CLORAMINA. [TWO CASES OF MYCOSIS 

FUNGOIDES TREATED WITH CHLORAMIN.] 

Dermosifilografo, 1949, 24: 120-122. 

2407 

Lenzi, F. CONSIDERAZIONI SUGGERITE DA UN CASO 

DI LINFOGRANULOMA ACUTISSIMO TRATTATO CON 

AZOIPRITE. [THERAPY OF ONE CASE OF ACUTE LYM 

PHOGRANULOMABY MEANS OF METHYL-BIS-(^ -CHLORO- 

ETHYDAMINE.] Atti Accad. fisiocrit. Siena 

sez. med. fis., 1950, 18: 224-236. 

2409 Levi, M., Mene, G. and Ferri, A. SULL'AZIONE 

DEL CLORIDRATO DI METIL-BIS-C f>-CLOROETIL) - 

AMINA DEL MORBO DI HODGKIN, NEL LINFOSARCO 

MA, NELLE LEUCEMIE E NEOPLASIE. [ACTION OF 

METHYL-BIS-(/^-CHLORETHYL)-AMINE HYDROCHLO- 

RIDE IN HODGKIN'S DISEASE, LYMPHOSARCOMA, 

LEUKEMIA AND NEOPLASTIC DISEASES.] Riv. pat. 

clin., Parma, 1951, 6: 1-58. 54 refs. 


5: No. 2389. 

2410 

Litvinova, E. V. USPESHNOE IZLECHENIE BOL'NOI 

RASPROSTRANENNYM RAKOM MOLOCHNOjTZHELEZY 

EMBIKHINOM V SOCHETANII S OPERATSIEÃ•. [SUC 

CESSFUL CURE OF A FEMALE PATIENT WITH DIS 

SEMINATED CANCER OF THE MAMMARY GLAND.] 

Vopr. onkol., 1955, 1: No. 2, 98-100. Twenty 

female patients with wide spread mÃ©tastases 

of mammary gland cancer were treated with 

embikhin. One detailed case report is des 

cribed. In doses of 8-10 mg 15 intravenous 

injections of embikhin No. 7 caused marked 

decrease in the lymph node swellings. The 

leucocyte count also decreased. Embikhin 

therapy was felt to have localized the tu 

mor growth which in turn permitted successful 

amputation of the left mammary gland. Three 

years following embikhin therapy and opera 

tion the patient was well and there were no 

remissions or mÃ©tastases. 

2411 

Â»Lopatina, V. Ã•A. EMBIKHINOT.ERAPI Ã•ALEÃ•KOZOV I 

LIMFOGRANULOMATOZA U DÃ‰TEI. [EMBIKHIN THERAPY 

OF LEUKEMIA AND LYMPHOGRANULOMATOSIS IN CHILD 

REN.] Leningrad, 1954. Pediat. Ued. lust,, 

1954. Dlsser. 

2412 

Lorenzo, J. de and Jannini, P. A MUSTARDA NITRO 

GENADA NO TRATAMENTO DO MAL DE HODGKIN. LINFO 

SARCOMA, LEUCEMIA E MOLESTIAS AFINS. [NITRO 

GEN MUSTARD IN THE TREATMENT OF HODGKIN'S 

DISEASE, LYMPHOSARCOMA, 

DISEASES.) Arq. clin., 

LEUKEMIA AND RELATED 

Rio, 1951, 12: 141-161. 

16 refs. 

2413 

Lovisetto, P. TERAPIA AZOIPRITICA IN ALCUNI 

CASI DI LINFOGRANULOMATOSI MALIGNA. [NITRO 

GEN MUSTARD THERAPY IN MALIGNANT LYMPHOGRA 

NULOMATOSIS.] Minerva 

40: pt. 2, 279-283. 

med., Tor., 1949, 

2414 

McCarthy, W. D. THE PALLIATION AND REMISSION 

OF CANCER WITH COMBINED CORTICOSTEROID AND 

NITROGEN MUSTARD THERAPY; 

CASES. N. England J. M., 

A REPORT OF 100 

1955, 252; 467-476. 

5 refs. 

2415 

Malaguzzi Valeri, C. and Di Raimondo, F. 

OSSERVAZIONI CLINICHE SULL'USO DELL'AZO 

IPRITE. [CLINICAL OBSERVATIONS ON THE 

APPLICATION OF NITROGEN MUSTARD.] 

Riforma med., 1949, 63: 661-667. 70 refs. 

Eleven cases. 

2416 

Malaguzzi-Valeri, C. and Di Raimondo, F. ULTER 

IORI OSSERVAZIONI SULL'IMPIEGO DELLE AZOIPRITI 

IN TERAPIA. [RECENT OBSERVATIONS ON THERA 

PEUTIC USE OF NITROGEN MUSTARDS.] 

Tor., 1954, 45: 1131-1139. tab. 

Minerva med., 

154 refs. 

2417 

Mallet, L.. Marchai, G. and Breton, H. NOTRE 

EXPÃ‰RIENCE DU TRAITEMENT 

HODGKIN PAR LE DI-METHYL 

DE LA MALADIE DE 

CHLORO-ETHYLAMINE 

(NITROGEN MUSTARDS). [OUR EXPERIENCES IN 

THE TREATMENT OF HODGKIN'S DISEASE WITH THE 

DI-METHYL CHLORO-ETHYLAMINE(NITROGEN MUS 

TARDS).] Paris med., 1948, 38: 299-301. 

2418 

Mallet, L., Marchai, G. and Breton, 11. NOTRE 

EXPERIENCE DU TRAITEMENT DE LA MALADIE DE 

HODGKIN PAR LE METHYL-BIS (NITROGEN MUSTARDS). 

[OUR EXPERIENCE WITH NITROGEN MUSTARD IN THE 

TREATMENT OF HODGKIN'S DISEASE.] Sang, Par., 

1948, 19: 564-570. Report of 9 cases, discussing~node 

of administration, dosage, 

tolerance and therapeutic effects.



139 


KS-O-CHLORO-, â€”¿ THERAPY (Continued) 

2419 

Manlio. F. UN CASO DI LINFOSARCOMA TRATTATO 

CON CLORAMIN. [ONE CASE OF LYMPHOSARCOMA 

TREATED WITH CHLORAMINE.] Minerva med., 

Tor., 1949, 40: pt. 2, 304-305. 

2420 

Marchai, G. LES TRAITEMENTS MODERNES DE LA 

MALADIE DE HODGKIN. 


[MODERN THERAPY OF 

Sem. hop. Paris, 1952, 

28: 96-106. See: Nitrogen mustards, p. 101- 

IÃœ3. 

2421 

Marinone, G. CLOROALCHILAMINE E LEUCEMIE ACUTE; 

STUDIO CLÃ•NICO ED ISTOPATOLOGICO DELL'AZIONE 

DEL CLORIDRATO DI METIL-BIS( /> -CLOROETIL) AMINA 

SULLA LEUCOSI EMOCITOBLASTICHE ACUTE. [CHLORO 

ETHYLAMINES AND ACUTE LEUKEMIAS; CLINICAL AND 

HISTOPATHOLOGICAL STUDY OF THE EFFECT OF HYDRO- 

CHLORIDE OF METHYL-BIS-ft-CHLOROETHYLAMINE IN 

ACUTE LEUKEMIAS.j Haematologica, Pavia, 1951, 

35: 993-1041. tab. Approx. 45 refs. English 

summaryÂ« 

2422 

Martinez Almeida, R. and Saenz Martin, P. 

LEUCEMIA MIELODIE CRONICA TRATADA CON MOSTAZA 

NITROGENADA. [NITROGEN MUSTARD THERAPY OF 

CHRONIC MYELOID LEUKEMIA.] Medicina, Madr., 

1949, 17: 380-383. 

2423 Masouredis, S. P., Low-Beer, B. V. A., Bierman, 

H. R., Cherney, L. S. and Shimkin, M. B. 

THE PARTITION OF RADIOPHOSPHORUS fp32) IN BLOOD, 

URINE AND TUMOR TISSUE IN PATIENTS WITH HODGKIN'S 

DISEASi. AND LYMPHOSARCOMA BEFORE AND AFTER TREAT 

MENT WITH NITROGEN MUSTARD (METHYL BIS(BETA- 

CHLOROETHYL) AMINE). J. Nat. Cancer Inst., 1950, 


mÃ«d., Sect. 5, 1952, 5: No. 3811; Chem. Abstr., 

1951, 45_: 3496a. 

2424 

Masuelli, L. UN CASO DI LEUCEMIA MIELOIDE 

CRONICA TRATTATA CON ETILURETANO; DUE CASI 

DI GRANULOMA MALIGNO TRATTATI CON CLORAMIN. 

[ONE CASE OF CHRONIC MYELOID LEUKEMIA TREATED 

WITH ETHYL-URETHANE ; TWO CASES OF MALIGNANT 

GRANULOMA TREATED WITH CHLORAMINE.] Minerva 

med., Tor., 1949, 40: pt. 2, 297-299. 

2425 

Mayer, E. and RosÂ»it, B. PALLIATIVE TREATMENT 

ON NON-RESPECTABLE PULMONARY NEOPLASMS: PRI 

MARY AND METASTATIC. 

1953, 53: 1647-1653. 

N. York 

6 refs. 

State J. M., 

Abstracted 


3620. 

2426 Medetti, M. I DERIVATI DELL'IPRITE NELLA 

TERAPIA INFANTILE. [NITROGEN MUSTARDS IN 

THE TREATMENT OF CHILDREN.] Osp. maggiore, 

Milano, 1952, 40: 38-40. 12 refs. 

2427 

Meyer, A. H. and Overmiller, W. C. USE OF A 

NITROGEN MUSTARD IN HODGKIN'S DISEASE AND 

LYMPHOSARCOMA. Ann. Int. M., 1949, 30: 

381-386. 4 refs. Treatment of 2 cases of 

Hodgkin's disease and 3 cases of lymphosarcoma. 

2428 

Michel, P. J.. Morel, R. and Moreteau, J. J. 

ESSAI DE TRAITEMENT SOUTENU PAR LES 

AZOTEES D'NN [SIC] MYCOSIS FONGOIDE 

MOUTARDES 

AU STADE 

PRÃ‰-TUMORAL. [ATTEMPT AT SUSTAINED TREAT 

MENT WITH NITROGEN MUSTARDS IN MYCOSIS FUNGOIDES 

IN THE PRETUMORAL STAGE.] Bull. Soc. fr. derm, 

syph., 1952, 59: 46-48. 

2429 

Myren, J. LYMPHOGRANULOMATOSIS MALIGNA; EN 

PASIENT BEHANDLET AMBULANT MED NITRASIN A-L. 

[MALIGNANT LYMPHOGRANULOMATOSIS; ONE AMBULANT 

PATIENT TREATED WITH NITRASIN A-L.] Tskr. 

Norske laegeforen., 1949, 69: 292-293. 

2430 

Nabarro, J. D. N. NITROGEN MUSTARD THERAPY IN 

THE RETICULOSES. 

507-510. 4 refs. 

Brit. J. Radiol., 1951, 24: 

2431 

Nabarro, J. D. N. NITROGEN MUSTARD THERAPY 

WITH SPECIAL REFERENCE TO HODGKIN'S DISEASE. 

Brit. M. J., 1949, 2: 622-625. 7 refs. 

2432 Nardi, F. L. TRATTAMENTO CON AZOTO-IPRITE DI 

ALCUNI CASI DI LINFOGRANULOMA MALIGNO E DI 

LINFOSARCOMA. [NITROGEN MUSTARD THERAPY OF 

VARIOUS CASES OF MALIGNANT LYMPHOGRANULOMA 

AND LYMPHOSARCOMA.] 

6_7: 169-177. 

Accad. med.. Tor., 1952, 

2433 Neu, H. N. HODGKIN'S DISEASE; A CASE OF AB 

DOMINAL HODGKIN'S DISEASE TREATED WITH 

METHYL-BIS-/Â» -CHLOROETHYLAMINE HYDROCHLORIDE. 

Bull. Creighton Univ. School M., 1947-48, 4: 

43-46. 5 refs. The toxic manifestations 

in the hematopoietic system of the patient 

and autopsy findings are reported in detail. 

2434 NITROGEN MUSTARD DRUGS IN NEOPLASTIC DISEASES. 

Am. Proies. Pharmacist, 1947, 13: 47-50, 89. 

2435 

Osborne, E. D., Jordon, J. W., Hoak, F. C. and 

Pschierer, F. J. NITROGEN MUSTARD THERAPY 

IN CUTANEOUS BLASTOMATOUS DISEASE. J. Am. 

M. Ass., 1947, 135: 1123-1128. 5 refs. 

2435* 

Pavan, S. SULL'AZIONE DELL'AZOIPRITE (CLORAMIN) 

SU DUE CASI DI MIELOSI LEUCEMICA E SU DI UN 

CASO DI LINFOGRANULOMA MALIGNO. [ON THE ACTION 

OF NITROGEN MUSTARD IN TWO CASES OF MYELOID 

LEUKEMIA AND IN ONE CASE OF MALIGNANT LYMPHO 

GRANULOMA.] Minerva med.. Tor., 1949 40: 

pt. 2, 287. 

2435b 

Pavlovsky, A. and Vilaseca, C. EL TRATAMIENTO 

DE LA ENFERMEDAD DE HODGKIN CON LAS MOSTAZAS 

NITROGENADAS. [TREATMENT OF HODGKIN'S DISEASE 

WITH NITROGEN BUSTARD.] Semana mÃ©d., B. Air., 

1949, 56: 486-490. Abstracted in: Chem. Abstr., 

1949, 53": 7143e. 

2436 Payard, B.J. and Beauchant, J. TRAITEMENT DE 

LA MALADIE D'HODGKIN. [TREATMENT OF HODGKIN'S 

DISEASE.] J. med. Bordeaux, 1953, 130: 171- 

176. See: Nitrogen mustard 173-175'. 

2437 

Â»Pedersen, E. ON TREATMENT OF SPONTANEOUS LEU 

KEMIA IN MICE WITH 

Acta path, microb. 

NITROGENIZED MUSTARD GAS. 

scand., 1950, 27: 9-15. 

Abstracted in: Excerpta med., SecTTT 5, 1950, 

3: No. 2882. 

243U 

Pedro-Botet, J. and Guix Melcior, J. R. VENENOS 

MITOTICOS Y RADIOTERAPIA. Â¡MITOTICPOISONS 

AND RADIOTHERAPY.] Med. clin., Barcelona, 

1954, 23: 83-90. 25 refs. 

2439 Periera, J. R. A. MOSTARDA NITROGENADA E DOENÃ‡A 

DE HODGKIN; 

GEN MUSTARD 

APRESENTACAO DE UN CASO. [NITRO 

AND HODGKIN'S DISEASE; ONE CASE 

REPORT.] Portugal mÃ©d., 1953, 37: 645-658. 

18 refs. 

2440 Philpott, 0. S., Woodburne, A. R. and Waldriff, 

G. A. NITROGEN MUSTARD IN THE TREATMENT OF 

MYCOSIS FUNGOIDES. J. Am. M. Ass., 1947, 

135: 631-633.



140 



2440a 

Plauchu, II. and Mouriquand, C. ESSAI DE TRAITE 

MENT PAR LA MOUTARDE A L'AZOTE (CARYOLYSINE) 

DE DIFFÃ‰RENTS CANCERS. A PROPOS DE QUINZE 

OBSERVATIONS. [TREATMENT WITH NITROGEN MUS 

TARD CCARYOLYSIN') IN VARIOUS TYPES OF CANCER 

(15 CASES).] Lyon raed., 1951, 185: 321-326. 

1 rÃ©f. Abstracted in: Excerpta med., Sect. 

2, 1952, 5: No. 5933. 

2441 

Plauchu, M Lehmann, M. and Lejeune, E. ESSAI 

DE LA MOUTARDE X L'AZOTE DANS LE TRAITEMENT 

DES CANCERS DE L'OESOPHAGE. [TREATMENT OF 

CANCER OF THE ESOPHAGUS WITH NITROGEN MUSTARD.] 

Arch. mal. app. digest., Par., 1952, Â«: 849- 

854. 10 refs. Abstracted in: Index analyt. 

cancer., Par., 1953, 24: No. 868. 

2442 

Policy, T. Z., and Brixey, A. M., Jr. THE 

CLINICAL USE OF NITROGEN MUSTARD. Med. 

Times, N. Y., 1951, 79: 1-6. 35 refs. 

244 Â¿a 

Pricolo, V. and Di Pietro, S. SULL'AZIONE TERA 

PEUTICA DI ALCUNI DERIVATI DELL'AZOIPERITE 

NEI TUMORI MALIGNI EPITELIALI E CONNETTIVALI. 

[ON THE THERAPEUTIC EFFECT OF CERTAIN NITROGEN 

MUSTARD DERIVATIVES ON MALIGNANT EPITHELIAL 

AND CONNECTIVE TISSUE TUMORS.] Tumori, 

Milano, I951, 37: 385-400. 31 reÃs. 

24-13 

Puente Duany, N. and Marinello, Z. NUESTRA EX 

PERIENCIA EN EL USO DE LA MOSTAZA NITROGENADA 

EN AFFECCIONES MALIGNAS DE Ã“RGANOS HEMATOPOYE- 

TICOS. [OUR EXPERIENCE IN THE USE OF NITRO 

GEN MUSTARD IN MALIGNANT DISEASES OF THE BLOOD 

SYSTEM.] Arch, cuban, cÃ¡ncer., 1948, 7: 245- 

254. Also in: Rev. raed, cubana, 1948,~59: 

689-698. 

2444 

Reitano, U., Giambrone, I. and Matalone, V. 

L'USO DELL'AZO-IPRITE NELL'ERITREMIA CRONICA. 

[THE APPLICATION OF NITROGEN MUSTARD IN CHRO 

NIC ERYTHREMIA.] Minerva med., Tor., 1949, 

40: pt. 2, 312-313. 

2445 

Remold, F. and Siegert, A. ÃœBER DIE ANWENDUNG 

VON NITROLOST BEI COLLUM- UND MAMMACARCINOM- 

R^ZIDIVEN, SOWIE BEI METASTATISCHEN KNOCHEN- 

UND LUNGENTUMOREN. [USE OF NITROGEN MUSTARD 

IN RECURRENT CARCINOMA OF BREAST AND CERVIX 

AND IN METASTATIC OSSEOUS AND PULMONARY TU 

MORS. ] Zschr. Krebsforsch., 1951, 57: 614- 


2446 Rhoads, C. P. NITROGEN MUSTARDS IN THE TREAT 

MENT OF NEOPLASTIC DISEASE; OFFICIAL STATE 

MENT. J. Am. M. Ass., 1946, 131: 656-658. 

4 refs. Abstracted in: Biol.~I5str., Bait., 

1947, 2^: No. 895. 

2447 

Rhoads, C. P. REPORT ON A COOPERATIVE STUDY OF 

NITROGEN MUSTARD (HN2> THERAPY OF NEOPLASTIC 

DISEASE. Tr. Ass. Am. Physicians, 1947, 60: 

110-117. Discussion: p. 117. 4 refs. 

2448 Richmond, G. H. and Beardsley, G. D. NITROGEN 

MUSTARD THERAPY COMPLICATED BY ACUTE RENAL 

FAILURE DUE TO URIC ACID CRYSTALLIZATION. 

Ann. Int. M., 1953, 39: 1327-1332. 10 refs. 

2449 

Rigonl, M. 

MEDIANTE 

LA CURA DEL LINFOGRANULOMA MALIGNO 

LA CLORO-AZO-IPRITE. [THE TREATMENT 

OF Â«ALIGNANT LYMPHOGHANULOMA WITH 

TARD.] Settimana ned., 1949, 37: 

NITROGEN 

205-206. 

MUS 

2450 

Ritis, F. de and ScalfÃ¬, L. TRE CASE DI LINFO 

GRANULOMA DI HODGKIN TRATTATI CON AZOTO-IPRITE. 

[THREE CASES OF HODGKIN'S DISEASE TREATED 

WITH NITROGEN MUSTARD.] Minerva med., Tor., 

1949, 40: pt. 2, 283-284. 

2451 

Romeo, G. SUL VALORE TERAPEUTICO DI ALCUNE 

SOSTANZE AD AZIONE ANTICELLULARE NELLE 

EMOPATIE A TIPO ERITROBLASTICO. [THERAPEU 

TIC VALUE OF CERTAIN ANTICELLULAR SUBSTANCES 

IN ERYTHROBLASTIC BLOOD DISEASES.] Acta 

paediat. lat., 1952, 5: 214-222. 5 refs. 


2452 

Rose, L. W., Jr., Tucker, H. S. G., Jr., Richman, 

S. and Willams, J. P. COMBINED NITROGEN MUS 

TARD AND SINGLE DOSE IRRADIATION TREATMENT OF 

LYMPHOMATA AND OTHER MALIGNANT TUMORS. Virginia 

M. Month., 1952, 79: 562-574. rÃ©f. 

2453 

Roswit, B. and Kaplan, G. NITROGEN MUSTARD AS 

AN ADJUNCT TO RADIATION IN THE MANAGEMENT OF 

BRONCHOGENIC CANCER. Radiology, 

384-394. pi. 34 refs. 

1951. 57: 

2454 Roswit, B. and Kaplan, G. THE ROLE OF NITROGEN 

MUSTARD AS A SYSTEMIC ADJUNCT TO THE RADIATION 

THERAPY OF CERTAIN MALIGNANT DISEASES. Am. J. 

Roentg., 1949, 61: 626-636. pi. 19 refs. 

2455 

Saita, G. UN CASO DI LINFOSARCOMA TRATTATO CON 

AZOTO-IPRITE. [ONE CASE OF LYMPHOSARCOMA 

TREATED WITH NITROGEN MUSTARD.] Minerva med.. 

Tor., 1949, 40: pt. 2, 302-303. 

24iartori, P. and Ajelli, C. CASI DI LINFOGRANU 

LOMA MALIGNO TRATTATI CON CLORIDRATO DI METIL- 

BIS-BETA-CLOROETIL-AMINA. [MALIGNANT LYMPHO- 

GRANULOMA TREATED WITH METHYL-BIS-ft-CHLORO- 

ETHYLAMINE HYDROCHLORIDE.] Minerva med., Tor., 

1949, 40: pt. 2, 285-286. 

2457 

Schwarz, H. II, CastaÃ±ares, S. and McAleese, G. 

PALLIATIVE THERAPY WITH FRACTIONATED INTRA- 

ARTERIAL NITROGEN MUSTARD; REPORT OF ITS 

USE IN A CASE OF PERSISTENT CANCER OF THE 

TONGUE WITH AN UNUSUAL COMPLICATION.] 

A. M. A. Arch. Surg., 1952, 64: 286-291. pi. 

2458 

Scrobogna, S. CONSIDERAZIONI SUGGERITE DA CASI 

DI EPITELIOMA CUTANEO TRATTATI CON YPRITI 

AZOTATE. [CASE OF CUTANEOUS EPITHELIOMA 

TREATED WITH NITROGEN MUSTARD.] 

1952, 38: 245-254. 47 refs. 


2459 

Sedan, J. EFFICACITÃ‰ DE LA MOUTARDE A L'AZOTE 

SUR UNE IRIDOCYCLITE DE HODGKIN. [EFFICACY 

OF NITROGEN MUSTARD 


ON IRIDOCYCLITIS IN 

Bull. soc. opht. France, 

1953, No. 9, 991-996. 

2460 

Sellei, C. and Graf, J. TAPAS.ZT.ALATOK A MUSTXR- 

NITROGEN THERAPIAS ALKALMAZASAVAL. [EXPERIENCE 

WITH NITROGEN MUSTARD THERAPY.] Orv. hetil., 

1948, 89: 

mustard~in 

542-544. tab. 13 refs. Nitrogen 

doses of 0.1 mg was administered 

to 29 patients with leukemias. The leukocyte 

count decreased, the spleen was reduced in 

size and the overall condition improved. The 

bis-version of nitrogen mustard had fewer 

toxic side effects than the tris-version. 

2461 

Sherry, M. NITROGEN MUSTARDS IN THE TREATMENT 

OF HODGKIN'S DISEASE AND LYMPHOSARCOMA. 

South. M. J., 1948, 41: 118-129. 

Results obtained in 6~~cases. 

4 refs. 

2462 Shullenberger, C. C., Watkins, C. H. and Kierland, 

R. R. EXPERIENCES WITH NITROGEN MUSTARD THERAPY. 

J. Am. M. Ass., 1949, 139: 773-777. 4 refs.



141 


BIS-(|3-CHLORO-, â€”¿ THERAPY (Continued) 

2463 

Skinner, E. F. and Carr, D. PALLIATIVE THERA 

PY OF INCURABLE INTRATHORACIC MALIGNANCIES. 

Am. Practitioner, 1952, 3: 900-910. 20 refs. 

Results obtained in 5 cases are described 

along with the dosage, method of administration, 

the reactions and results in therapy with methyl 

bis-f* -chloroethylamine and triethylene melamine. 

Roentgen ray therapy and supportive mea 

sures are discussed. 

2464 

Skinner, E. F., Carr, D. and Denman, W. E. 

THE TREATMENT OF INOPERABLE BRONCHIOGENIC 

CARCINOMA WITH METHYL-BIS. J. Thorac. 

Surg., 1948, 17: 428-438. Discussion: 

437-438. 4 rÃ«Ts. Abstracted in: Excerpta 

med., Sect. 5, 1949, 2: No. 1693. 

2465 

Siddon, W. H. and Wells, B. B. NITROGEN MUS 

TARD TREATMENT IN CHRONIC MYELOGENOUS LEU 

KEMIA. J. Arkansas M. Soc., 1948, 44: 

203-206. 6 refs. A review and report of 

treatment of 3 cases. It is suggested that 

the combination of nitrogen mustard and 

X-ray may be expected to give more bene 

ficial effects than either of the treatments 

used alone. 

2466 

Silva, M. S. LINFOMA FUNGOIDE (MICOSE FUNGOIDE): 

TRATAMENTO PELA MOSTARDA NITROGENADA. ["FUNGOID 

LYMPHOMA" (FUNGOID MYCOSIS); NITROGEN MUSTARD 

THERAPY.] 

30 refs. 

Rev. brasil, med., 1952, 9: 381-386. 

One case history discussed~in detail. 

2467 Snider, G. E. THE TREATMENT OF BOECK'S SARCOID 

WITH NITROGEN MUSTARD; A PRELIMINARY REPORT. 

South. M. J., 1948, 41: 11-14. 11 refs. 

2468 

Sorokin, N. M. K VOPROSU O LECHEBNOM PRIMENENII 

EMBIKHINA. [ON THE THERAPEUTIC APPLICATION 

No. 

OF EMBIKHIN.J 

6, 75-77. Embikhin 

Klin, med., 

(nitrogen 

Moskva, 

mustardj~in 

1954, 32: 

total doses of 42-57 mg per patient was tested 

on 17 cases of lymphogranulomatosis, lymphosarcoma 

and myeloid and lymphoid leukemias. 

The drug decreased the leucocyte count, improved 

the overall condition of the patients and in 

1 case inhibited the growth of the tumor. 

Only two patients showed no toxic side effects. 

Embikhin 

junction 

is more effective when given in con 

with X-ray therapy, especially at 

the outset of the disease. 

2469 

Sperlich, W. EIN BEITRAG ZUR BEHANDLUNG DER 

POLYCYTHAEMIA VERA MIT STICKSTOFFLOST. [NI 

TROGEN MUSTARD TREATMENT OF POLYCYTHEMIA VERA.l 

Med. Klin., Beri., 1949, 44: 1533-1534. 8 refs. 

247O 

Sprague, C. 

Louisiana 

C. 

M. 

TREATMENT OF LEUKEMIA. J. 

Soc., 1954, 106: 445-450. 


2471 Spurr, C. L., Jacobson, L. 0., Smith, T. R. and 

Barron, E.S.G. THE CLINICAL APPLICATION OF 

METHYL-BIS(^ -CHLOROETHYL)AMINE HYDROCHLO- 

RIDE TO THE TREATMENT OF LYMPHOMAS AND ALLIED 

DYSCRASIAS. In: APPROACHES TO TUMOR CHEMO 

THERAPY. WasET, Am. Ass. Advance. Sc., 1947, 

p. 306-318. 7 refs. 

2472 

Spurr, C. L., Smith, T. H. and Jacobson, L. O. 

CHEMOTHERAPY IN HUMAN LYMPHOMAS, LEUKEMIAS, 

AND ALLIED DISORDERS OF THE HEMOPOIETIC SYS 

TEM. Radiology, 1948, 50: 387-394. 17 refs. 

Spanish summary: p. 393^394. 

2473 Spurr, C. L., Smith, T. R., Block, M. and 

Jacobson, L. O. A CLINICAL STUDY OF THE 

USE OF NITROGEN MUSTARD THERAPY IN POLYCY 

THEMIA VERA. J. Laborat. Clin. M., 1950, 

35: 252-264. 44 refs. Treatment with HN2 

re"duced the average hematocrit from 59 to 

44 per cent in 4.4 weeks. The average 

period of remission for 10 cases was 6.5 

months. 

2474 Spurr, C. L., Smith, T. R., Block, M. and 

Jacobson, L. 0. THE ROLE OF NITROGEN MUS 

TARD THERAPY IN THE TREATMENT OF LYMPHOMAS 

AND LEUKEMIAS. Am. J. Med., 1950, 8: 710- 

723. 31 refs. "This report evaluates the 

clinical course of 95 cases on HN2 therapy 

from 3 to 66 months. The group includes 27 

cases reported by this clinic in 1946. The 

survival of 40 patients with Hodgkin's 

disease averaged 40 months with a response 

to HN2 of 12 months. The 17 patients still 

alive have responded 22.4 months and have 

had an average duration of 65 months...The 

response of lymphosarcoma and chronic lym 

phatic leukemia is of sufficient promise to 

suggest continued use of HN2 therapy in 

cases selected according to certain clinical 

features." 

2475 

Stafford, Â«f.B. A CASE OF CHRONIC LYMPHATIC 

LEUCHAEMIA TREATED WITH BIS-ÃŸ -CHLOROETHYL 

AMINE. Med. J. Australia, 1948, 2: 208-209. 

rÃ©f. Nitrogen mustard is not recommended in 

chronic lymphatic leukemia except in early 

or intermediate cases which respond poorly 

to X-ray therapy. 

2176 

Â«Storti, E., Allegri, A. and Hocchi, N. IL BIS- 

BETA-CLOROETILMETILAMINA-CLORIDRATO NELLA 

TERAPIA DEL LINFOGRANULOMA MALIGNO. 

BIS ( B-CHLOROETHYDAMINE THERAPY OF 

[METHYL- 

MALIGNANT 

LYMPHOGRANULOMA.] Minerva med., Tor., 1949, 

40: pt. 1, 737-741. Digest in: Minerva med., 

Tor., 1949, 40: pt. 2, 285. 

2477 

Storti, E., Allegri, A. and Mocchi, N. LA 

TERAPIA DEL LINFOGRANULOMA MALIGNO CON BIS- 

BETA -CLOROETIL-METIL-AMINA CLORIDRATO. 

CONTRIBUTO CLÃ•NICO EMATOLOGICO. [BIS-0 - 

CHLOROETHYLMETHYLAMINE HYDROCHLORIDE IN 

THERAPY OF MALIGNANT LYMPHOGRSNULOMA; 

CLINICAL AND HEMATOLOGIC STUDY.] Haematologica, 

Pavia, 1949, 33: 149-212. 26 refs. 


2478 Sullivan, R, D., Jones, R., Jr., Schnabel, T. G., 

Jr. and Shorey. J. M. THE TREATMENT OF HUMAN 

CANCER WITH INTRA-ARTERIAL NITROGEN MUSTARD 

(METHYL-BIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE) 

UTILIZING A SIMPLIFIED CATHETER TECHNIQUE. 


2479 

Suriyong, R. LE TRAITEMENT DE LA POLYCYTHÃ‰MIE 

PAR LE CHLORHYDRATE DE N-BIS-METHYL (BETA- 

CHLORETHYL)-AMINE. [TREATMENT OF POLYCYTHEMIA 

WITH NITROGEN MUSTARD.] Helvet. med. acta, 

1948, 15: 465-469. 10 refs. 

248U Sweitzer, S. Â£., Curaming, H. A. and McAfee, 

G. D. LYMPHOSARCOMA TREATED WITH NITROGEN 

MUSTARD; REPORT OF A CASE. Arch. Derm. 

Syph., Chic., 1950, 61: 12-19. pi. 9 refs. 

2481 

Taffel, M. EXPERIENCES IN THE TREATMENT OF 

NEOPLASTIC DISEASE WITH NITROGEN MUSTARD. 

Yale J. Biol., 1947, 19: 971-977. 8 refs. 

Abstracted in: ExcerpTa" med., Sect. 5, 1949, 

2: No. 1462. 

2462 

Tan, T. H. STIKSTOFMOSTERD-THERAPIE. [ÃŸ-CHLOR- 

ETHYLAMINE, ALKYLAMINE, "NITROGEN MUSTARD."] 

Med. mbl., Batavia, 1948, 370-373. 7 refs.



142 



2483 

Terzani, A., Di Lollo, F. and Weber, A. PRIMI 

RISULTATI 

PARATI DI 

DI ESPERIENZE 

AZOTO-IPRITE. 

TERAPEUTICHE CON PRE 

[FIRST RESULTS OF 

EXPERIMENTAL THERAPY WITH NITROGEN-MUSTARD 

COMPOUNDS.] Minerva 

pt. 2, 315-317. 

med., Tor.. 1949, 40: 

24?estolin, M. and Orsolini, C. SU DI UN CASO 

DI LINFOADENOSI CRONICA TRATTATO CON AZO- 

IPRITE (CLORAMIN). [NITROGEN MUSTARD (CHLORA- 

MINE) THERAPY OF LYMPHADENOSIS.] Minerva med., 

Tor., 1950, 41: 269-270. 

2485 

Thiers, H., Romagny and Blanc A PROPOS D'UN CAS 

DE MALADIE DE HODGKIN TRAITÃ‰ PAR DES SERIES 

ALTERNANT LA MOUTARDE itL'AZOTE ET UN DÃ‰TOXI- 

CANT A FONCTION THIOL(THIOMALATE DE SOUDE). 

[HODGKIN'S DISEASE TREATED BY ALTERNATING 

NITROGEN MUSTARD AND A DETOXICANT WITH THIOL 

FUNCTION (SODIUM THIOLATE; REPORT OF A CASE.] 

Bull. Soc. fr. derm, syph., 1950, 57: 519-520. 

2486 Thurber, D. C. NITROGEN MUSTARD THERAPY. Bull. 

M. Soc. Co. Monroe, 1948, 5: 350-364. 

24Tocantins, L. M. and Woldow, I. EXPERIMENTACIÃ“N 

QUIMIOTERAPICA EN LOS LINFOMAS MALIGNOS. 

[CHEMOTHERAPY OF MALIGNANT LYMPHOMAS.] AmÃ©rica 

clin., 1948, 13: 533-540. 4 reÃs. 

2488 

TREATMENT OF ADVANCED CANCER. N. England J. M., 

1955, 252; 502-503. 4 reis. An editorial 

discussion of: McCarthy, W. D. The palliation 

and remission of cancer with combined corticosteroid 

and nitrogen mustard therapy; a re 

port 

252: 

of 100 cases. 

467-476. 

N. England J. M.,1955, 

2489 

Tsvetkov, J. I. and Gurevich, L. I. OPYT 

LECHENIIA BOL'NYKH S MNOZHESTVENNOÃ• MIELOMOÃ• 

(BOLEZN1 RUSTITSKOGO). [TREATMENT OF MULTIPLE 

MYELOMA (MORBUS RUSTITSKll).] Sovet. med., 

1955, 19: No. 2, 56-58. Embikhin and radio 

phosphÃFus treatment gave positive results in 

two cases of multiple myeloma. 

24Tucker. H. St. G., Jr. CHEMOTHERAPY OF LYMPHOMA. 

Virginia M. Month., 1954, 81: 169-170. 

2491 

Tucker, H. St. G., Jr. and Kay, W. R. NITRO 

GEN MUSTARD TREATMENT OF HODGKIN'S DISEASE. 

Virginia M. Month., 1949, 76: 502-510. 

Discussion: p. 508-510. 12~~refs. A report 

of 24 cases. 

249!) 

Ultzmann, H. N-LOST-ANWENDUNG IN DER UROLOGIE; 

VORLÃ„UFIGE MITTEILUNG. [THE USE OF NITROGEN- 

MUSTARD IN UROLOGY; PRELIMINARY REPORT.] 

Zschr. Urol., 1951, 44: 167-172. Abstracted 


24 UÃŽtzmann, H. N-LOST-THERAPIE IN DER UROLOGIE. 

[NITROGEN-MUSTARD TREATMENT IN UROLOGY.] 

Zschr. Urol., 1953, 46: 97-105. Approx. 

45 refs. Abstraeted~Tn: Excerpta med., 

Sect. 16, 1954, 2: No. 194. "On the basis 

of 45 cases, a survey is given of the re 

sults obtained by nitrogen-mustard treat 

ment in combination with X-ray treatment in 

cases of malignant tumour in the field of 

urology." -Excerpta med. 

2494 

Urteaga Ballon, O., DiÃ©guez, J., Zavaleta, A. 

and Zubiate, P. TRATAMIENTO DE LAS 

LEUCEMIAS CON ALKILAMINAS, I. LEUCEMIAS 

CRÃ“NICAS. [TREATMENT OF LEUKEMIAS WITH 

ALKYLAMINES, I. CHRONIC LEUKEMIA.] 

perÃ¹. par. clin., 1947, Â±: 185-257. 

Arch, 

32 pi. 

15 refs. English summary, p. 756. 

2502 

Werff, J. T. van der STIKSTOFMOSTERDGASTHERAPIE. 

[NITROGEN MUSTARD THERAPY.] Ned. tschr. geneesk., 

1948, 92: 4092-4100. 12 refs. 

2495 

Urteaga BailÃ³n, o., DiÃ©guez, J., Zavaleta, A. 

and Zubiate, P. TRATAMIENTO DE LAS LEUCE 

MIAS CON ALKILAMINAS. II. LEUCEMIAS AGUDAS. 

[TREATMENT OF LEUKEMIAS WITH ALKYLAMINES. 

II. ACUTE LEUKEMIAS.] Arch. Peru. pat. 

clin., 1947, l_:383-470. 56 pi. 17 refs. 

English summary: p. 758. 

2496 

Vargas y Vargas, L. and Soto, A. R. NITRÃ“GENO 

MOSTAZA (DEMA) EN EL TRATAMIENTO DE LA EN 

FERMEDAD DE HODGKIN. [NITROGEN MUSTARD 

IN,THE TREATMENT OF HODGKIN'S DISEASE.] 

(DEMA) 

Bol. 

med. Hosp. inf., MÃ©x., 1947, 4: 563-576. 

6 refs. Four cases. 

2497 

Vetne, G. EN STATUS OVER BEHANDLINGEN AV 

LEVKEMIER OG MALIGNE LYMFOMER. [REVIEW OF 

TREATMENT OF LEUKEMIAS AND MALIGNANT LYM 

PHOMAS.] Tskr. Norske laegeforen., 1953, 

73: 347-349. 5 refs. English summary. 

2498 

Videbaek, A. ON THE USE OF NITROGEN MUSTARD 

AS A THERAPEUTIC AGENT. Acta med. scand., 

1949, 135: 47-53. 19 refs. Report of 

experience with methyl-bis-,3 -chloroethylamine 

in 35 patients: 22 cases of Hodgkin's 

disease, 4 of chronic leukemia, 1 of myelomatosis, 

2 of polycythemia, and 6 of metastasizing 

carcinoma of the lung. Toxic 

reactions are dealt with in detail. 

2499 Warter, J., Voegtlin, R. and Boise, R. POLY- 

GLOBULIE; ACTION FAVORABLE DE L'YPÃ‰RITE 

NITREE. [POLYCYTHEMIA VERA; FAVORABLE ACTION 

OF NITROGEN MUSTARD.] Bull. Soc. mÃ©d. hop. 

Paris, 1949, 6jj: 1086-1091. 9 refs. 

2500 Wawro, N. W. EXPERIENCE WITH THE USE OF NITRO 

GEN MUSTARD AT THE HARTFORD HOSPITAL. Connecti 

cut M. J., 1948, 1Â£: 625-631. 7 refs. 

2501 

Weiss Valbranca, G. and Spigliati, P. IL METIL 

BIS (BETACLOROETIL) AMINA CLORIDRATO NEL 

TRATTAMENTO DEL LINFOGRANULOMA MALIGNO E DELLA 

MIELOSI LEUCEMICA CRONICA. iMETHYL-BIS-/S- 

CHLOROETHYLAMINE IN THE TREATMENT OF HODGKIN'S 

DISEASE AND CHRONIC MYELOID LEUKEMIA.] Riv 

clin, med., 1948, 48: 499-511. 8 reis. Digest 

in: Minerva med., Tor., 1949, 40: pt. 2, 284- 

2503 

Wild, H. VERSUCH EINER BEHANDLUNG PRIMÃ„RER 

LUNGENTUMORENMJT STICKSTOFF-LOST(NITROGEN- 

MUSTARD). VORLAUFIGE MITTEILUNG. [NITRO 

GEN MUSTARD IN THE TREATMENT OF PRIMARY 

PULMONARYCANCER; PRELIMINARY REPORT.] 

Klin. Wschr., 1949, 27^: 232-234. 

2504 

Â«Wilkinson, J. F. and Fletcher, F. EFFECT OF 

,3 -CHLORETHYLAMINE HYDROCHLORIDES IN LEUKAE 

MIA, HODGKIN'S DISEASE AND POLYCYTHAEMIA VERA. 

Lancet, Lond., 1947, 253: 540-545. Abstracted 

in: Biol. Abstr., BalÃ¯TT 1948, 22: No. 16358. 

2505 Winkler, L. STICKSTOFFLOSTTHERAPIE BEIM FORT 

GESCHRITTENEN MAMMACARCINOM. [TREATMENT OF 

ADVANCED MAMMARY CARCINOMA WITH NITROGEN 

MUSTARD.] Beri. med. Zschr., 1951, 2: 53-56. 

19 refs. Seven patients with advanced mam 

mary carcinoma were treated with a total 

amount of 12.5-95 mg of methyl-bis-/9-chloroethylamine 

hydrochloride, which was adminis 

tered intravenously in daily 

In five cases a remission of 

doses of 2.5 mg. 

3-5 weeks was 

produced consisting of an improved general 

condition, regression of edema and pleural 

effusion. Nitrogen mustard, especially 

combination with X-ray treatment, is re 

in 

commended for its palliative effects.



143 



2506 

Wintrobe, II. II. NITROGEN MUSTARD THERAPY. Am. 

J. Â«ed., 1948, 4: 313-314. 9 refs. An edi 

torial. Also in: Bull. Chicago M. Soc., 1949. 

5_1: 557. 

2507 

Wintrobe, II.II. and Huguley, C. M., Jr. NITRO 

GEN MUSTARD THERAPY FOR HODGKIN'S DISEASE, 

LYMPHOSARCOMA, THE LEUKEMIAS, AND OTHER DIS 

ORDERS. Cancer, N. Y., 1948, U 357-382. 

2508 

Wintrobe, M. M., Huguley, C. M., Jr., McLennan, 

M. T. and Carvalho Lima, L. P. de NITROGEN 

MUSTARD AS A THERAPEUTIC AGENT FOR HODGKIN'S 

DISEASE, LYMPHOSARCOMA, AND LEUKEMIA. Ann. 

Int. M., 1947, 27: 529-540. 5 refs. Abstrac 

ted in: Biol. Abiitr., Bait., 1948, 22: No. 

13878; Chera. Abstr., 1948, 42; 679dT~ 

2509V 

.Â»ianiewski,B. KILKA UWAG O LECZENIU ZIARNICY 

ZfcOSLIWEJ IPERYTEM AZOTOWYM. [TREATMENT OF 

MALIGNANT GRANULOMA WITH NITROGEN MUSTARD.] 

Polski tygod. lek., 1952, 7: 752-757. 23 refs. 

2510 

Woodruff, A. W. NITROGEN MUSTARD IN POLYCYTHAE- 

MIA VERA. Brit. B. J. , 1948, 2: 299. rÃ©f. 


2: No. 3185. 

2511 

Zanes, R. P., Doan, C. A. and Hoster, H. A. 

STUDIES IN HODGKIN'S SYNDROME. VII. NITRO 

GEN MUSTARD THERAPY. J. Laborat. Clin. M., 

1948, 33: 1002-1018. 15 refs. 

See 

230 

550 

1750 

2515 

2633 

3413 

TOXICITY 

441 

573 

1925 

2516 

2685 

3426 

459 

679 

2123 

2517 

2859 

3441 

520 

1206 

2194 

2574 

3111 

3459 

523 

1271 

2511,1 

2630 

3390 

2511a 

Barberio, J. R., Klopp, C. T., Ayres, W. W. and 

Gross, H. A. EFFECTS OF INTRA-ARTERIAL AD 

MINISTRATION OF NITROGEN MUSTARD. Cancer 

N. Y., 1951, 4: 1341-1363. 2 pi. 14 refs. 

Abstracted in: Excerpta med., Sect. 5 1952 

5: No. 3145. ' 

2512 

Gadermann, E. ZUR FRAGE TOXISCHER SCHÃ„DIGUNGEN 

BEI DER STICKSTOFF-LOST-BEHANDLUNG. [PROBLEM 

OF TOXIC EFFECTS OF NITROGEN MUSTARD THERAPY] 


2513 

Hammond, C. W., Tompkins, M. and Miller, C. 

OCCURRENCE OF GENERALIZED INFECTION OF ENTERIC 

ORIGIN IN MICE POISONED WITH NITROGEN MUSTARD. 


140. 11 refs. 

2514 

Houck, C. R., Crawford, B., Bannon, J. H. and 

Smith, H. W. STUDIES ON THE MECHANISM OF 

DEATH IN DOGS AFTER SYSTEMIC INTOXICATION 

BY THE INTRAVENOUS INJECTION OF METHYL-BIS 

(ft-CHLOHOETHYDAMINE OR TRIS (4 -CHLOROETHYL) 

AMINE. J. Pharm. 

292. 32 refs. 

Exp. Ther., 1947, 90: 277- 

â€”¿ 

2515 Mills, E. S. NITROGEN MUSTARD-A DANGEROUS THERA 

PEUTIC AGENT. Tr. Ass. Am. Physicians, 1951, 

64: 392-403. 9 refs. 

2516 

Roswit, B. and Pisetsky, J. E. TOXIC PSYCHOSIS 

FOLLOWING NITROGEN MUSTARD THERAPY. J. Nerv 

Ment. Dis., 1952, 115; 356-359. 12 refs. 

2517 Sullivan, R. D., Mescon, H., Jones, R., Jr. and 

Miller, H. THE EFFECT OF INTRA-ARTERIAL NI 

TROGEN-MUSTARD (METHYLBIS[2-CHLOROETHYL]AMINE 

HYDROCHLRIDE) THERAPY ON HUMAN SKIN. Cancer 

Phila., 1953, 6: 288-293. 10 refs. 

2518 

Teilum, G. STUDIES ON PATHOGENESIS OF AMYLOI- 

DOSIS. II. EFFECT OF NITROGEN MUSTARD IN 

INDUCING AMYLOIDOSIS. J. Laborat. Clin M 

1954, 43: 367-374. 9 refs. 

2519 

Trams, E. G., Cornman, I. and Klopp, C. T. 

EXCLUSION OF THE SPLEEN FROM THE ACTION OF 

INTRAVENOUSLY ADMINISTERED NITROGEN MUSTARD 

Am. J. Physiol., 1953, 174: 391-392. 5 refs. 

[2520-2524 not used] 

See 

1904 

2123 

2183 

2449 2457 3470 

â€¢¿ TOXICITY, COUNTERACTION OF 

2184 2399 

2525 

Desaive, p. and Varetto-Denoel. J. YPKRITE 

A L'AZOTE ET RADIO-PROTECTION CHIMIQUE 

[NITROGEN MUSTARD AND CHEMICAL RADIO-PRO 

TECTION.) Acta UniÃ³ internat, cancr 

Louvain, 1955, U: 115-138. 84 refs. "The 

object of this research is to show the pro 

tecting effect of /3-mercaptoethylamin(Becaptan 

Labaz) towards intestinal lesions 

caused in the Rat by intraperitoneal injec 

tion of 

(HN2)." 

200 gamma of nitrogen mustard 

2526 

Domokos, J. and Kelemen, E. EXPERIMENTS WITH 

PYRIDOXINE RESPECTIVELY CHOLINE TO PREVENT 

VOMITING RESPECTIVELY BONEMARROW DAMAGE 

CAUSED BY NITROGEN MUSTARDS. Internat. Zschr 

Vitaminforsch., Bern, 1950, 21: 443-448 

21 refs. 

2527 

Howe, G. W., Marvin, H. N. and Spurr, C. L. 

EVALUATION OF CHOLINE AND RELATED SUBSTANCES 

AS ANTITOXIC AGENTS TO NITROGEN MUSTARD IN 

VIVO. Texas Rep. Biol. M., 1952, 10: 39-44 

18 refs. 

2528 

Paparopoli, G. AZIONE DELLA METIONINA SU 

ALCUNE MANIFESTAZIONI TOSSICHE DELLE AZOIPRITI, 

[EFFECT OF METHIONINE ON TOXIC EFFECTS OF NI 

TROGEN MUSTARDS. Sicilia san.. 1952, 5: 227- 

228. 

See 

2179 

NITROGEN MUSTARDS. ETHYLAMINE, METHYL BIS- 

(0-CHLORO -, N-OXTDE -, â€”¿ EFFECT ON MALIG 

NANT GROWTH 

2529 

Aiko, I., Owari, S. and Torigoe, M. NITROGEN 

MUSTARD N-OXIDE AND ITS EFFECT ON THE YOSHIDA 

SARCOMA. J. Pharm. 

1297-1300. 7 refs. 

Soc. Japan. 1952, 72: 

In Englisn. "OUt-of 29 

tumor animals treated with 10-20 mg/kg intra 

peritoneal dose of MBAO [N-oxide of HN2] 12 

(41.3%) were cured and average life length 

of the dead animals was 30 days, while in 

an experiment with MBA [HN2] it resulted in 

20% curability 

length." 

and 17 days of average life



144 


BIS-(0-CHLORO-, N-OXIDE-, â€”¿ EFFECT ON 

MALIGNANT GROWTH (Continued) 

2530 Aruii, T., Kaise. A. and Odashima, S. INHIBI 

TING EFFECTS OF NITROMIN UPON SUBCUTANEOUS- 

LY TRANSPLANTED SOLID TUMORS OF HEPATOI1A. 

Gann, Tokyo, 1953, 44: 395-396. In Japanese, 

2531 Ishidate, 11., Kobayashi, K.. Sakurai, Y., Sato, 

H. and Yoshida, T. EXPERIMENTAL STUDIES ON 

CHEMOTHERAPY OF MALIGNANT GROWTH EMPLOYING 

YOSHIDA SARCOMA ANIMALS. II. THE EFFECT OF 

N-OXIDE DERIVATIVES OF NITROGEN MUSTARD. 

Proc. Japan Acad., 1951, 27: 493-500. 4 reÃs. 

In English. 

2532 Ishidate, M., Sakurai, Y., Yoshida, T., Sato, 

H. and Kobayashi, K. EXPERIMENTAL STUDIES 

ON CHEMOTHERAPY OF MALIGNANT GROWTH EMPLOY 

ING YOSHIDA SARCOMA ANIMALS. III. THE EF 

FECT OF N-OXIDE DERIVATIVES OF NITROGEN 

MUSTARDS. Gann, Tokyo, 1952, 43: 171-174. 

In Japanese. 

Kaise, A. and Sato, H. CHANGES IN THE NUMBER 

OF MITOSIS OF YOSHIDA SARCOMA CELLS FOLLOWING 

NITROMIN TREATMENT. Gann, Tokyo, 1953, 44: 


2534 

Kaziwara, K. MORPHOLOGICAL OBSERVATIONS ON 

THE MECHANISM OF THE EFFECTS OF NITROGEN 

MUSTARD N-OXIDE UPON YOSHIDA SARCOMA CELLS! 

Acta path. Jap., 1953, 3:137-159. 

2535 Kaziwara, K. ON THE INHIBITORY EFFECT OF NITRO 

GEN-MUSTARD N-OXIDE (MBAO) UPON SUBCUTANEOUS 

SOLID TUMORS OF THE YOSHIDA SARCOMA. Gann, 

Tokyo, 1952, 43: 328-329. Forty-two albino 

rats bearing Yoshida sarcoma were treated 

with total doses of 4-10 Â«g of the drug. 

"In 21 of them (50%) the tumors regressed 

completely, each of them being observed over 

60 days. 9 rats died of emaciation with 

manifest decrease of body weights. The re 

maining 12 rats which were not cured com 

pletely of the tumors indicated the prolonga 

tion of life days...the average survival 

period being 26.2 days, about 10 days longer 

than that 

of 2.0 mg 

of the untreated...a single dose 

is sufficient for this regression." 

"iuziwara K. and Kobayashi, K. ON THE MINIMAL 

EFFECTIVE DOSE OF NITROGEN MUSTARD N-OXIDE 

(MBAO) ON THE YOSHIDA SARCOMA. Gann, Tokyo, 

1952, 43: 322-323. In English. 

2537 Kaziwara, K., Nakamura, K. and Odashima, S. 

NITROMIN EFFECT ON AZO DYE CARCINOGENESIS. 

I. Gann, Tokyo, 1954, 45: 526-527. In 

English. Nitromin treatment had no inhi 

biting effect on azo dye induced tumors in 

albino rats. 

25Kobayashi, K. DETAILS OF INHIBITING EFFECT OF 

THE NITROGEN MUSTARD N-OXIDE (MBAO) UPON THE 

YOSHIDA SARCOMA. [In Japanese] Gann, Tokyo, 

1952, Â«: 324-326. 

2539 RoÃ±o. O., Terashima, H., Azuma, S. and Murata, 

Y. A STUDY OF GROWTH OF ASCITES HEPATOMA 

AND YOSHIDA SARCOMA IN RATS AND CHANGES 

CAUSED BY NITROMIN TREATMENT. Gann, Tokyo, 

1954, 45: 536-538. In English. 

25Lettre, H. DAS YOSHIDA-SARKOM DER RATTE. [THE 

YOSHIDA SARCOMA OF THE RAT.] Zschr. Krebsforsch., 

1953 59: 287-297. 22 refs. A review. The in 

hibiting effect of methyl-bis-(/3-chloroethyl)- 

amine-N-oxyde is described. 

2541 Sato, H., Aruji, T. and Kaziwara, K. ON INHIBI 

TORY EFFECTS OF NITROGEN MUSTARD N-OXIDE (MBAO) 

UPON THE ASCITES HEPATOMA. 

43: 336-338. In English. 

Gann, 

"...in 

Tokyo. 1952, 

16 animals 

IrTtraperitoneal injections of 1.0-2.0 mg were 

repeated, each animal receiving 4-9 injections. 

Total dose reached 4-10 mg. 6 out of 16 (38%) 

have recovered from the disease. In the re 

mainder evident prolongation of the survival 

days (30 days in average) was obtained..." 

2542 Satoh, H. and Kaise, A. ORAL ADMINISTRATION OF 

NITROMIN 

HEPATOMA 

TO THE YOSHIDA SARCOMA 

ANIMALS. Gann, Tokyo, 

AND THE ASCITES 

1953, 44: 390- 


2543 

Shimada, J., Takahashi, T., Manabe, H. and 

Sugimoto, A. HISTOCHEMICAL INFLUENCES 

OF NITROMIN ON THE ASCITES 

Tokyo, 1954, 45: 523-525. 

HEPATOMA. Gann, 

In Japanese. 

2544 

Tasaka, S., Tomizuka, Y., Shikama, S., Orni, T., 

Kazato, Y., Nitta, J., Tsuchiya, Y., Otani, 

A., Uchiyama, M. and Tamaki, T. EXPERIMENTAL 

STUDIES ON NITROGEN-MUSTARD N-OXIDE. Gann, 


2545 

Tokuyama, K,., Hashimoto, K., Sawada, A., Mizota, 

T. and Tsukada, K. THE EFFECT OF NITROMIN 

UPON THE 

CLINICAL 

MALIGNANT 

STUDIES. 

TUMORS; EXPERIMENTAL AND 

Gann, Tokyo, 1954, 45: 505- 


2546 

Tokuyama, H. and Mizota, S. EFFECT OF NITROMIN 

ON THE YOSHIDA SARCOMA. Gann, 

44: 368-369. In Japanese. 

Tokyo, 1953, 

See 

94 

3533 

308 1893 2216 3073 


2547 

Baserga, A., Marinone, G. and Castelletti, P. E. 

SULLE MODIFICAZIONI DELLE CELLULE MIDOLLARI 

DA AZOIPRITE. [CHANGES IN MARROW CELLS DUE 

TO NITROGEN MUSTARD.] Haematologica, Pavia, 

1949, 3J5: 229-235. 3 pi. 15 refs. 

2548 Kaise, A. EFFECT OF NITROMIN UPON THE MITOSIS 

OF NORMAL CELL IN RATS. Gann, 

44: 389-390. In Japanese. 

Tokyo, 1953, 

2549 Kanno, M., Utimi, N. and Ichikawa, K. INFLUENCE 

OF NITROGEN MUSTARD-N-OXIDE UPON BLOOD PICTURE 

AND BONE MARROW. Tohoku Igaku zassi, 1954, 


Ã„Dstr., 1954, 48: 5366b. In Japanese. 

2550 Katahira, T., Sasaki, E. and Sugimoto, A. 

HISTOCHEMICALOBSERVATIONSON THE RABBIT 

BLOODCELL AND HEMOPOIETICTISSUES, ES 

PECIALLY ON THE EFFECTS OF NITROMINAND 

TEM. Gann, Tokyo, 1954, 45: 519-521. 

In Japanese. 

METABOLISM ( INCLUDING EFFECTS 

PROCESSES) 

ON METABOLIC 

2551 

Hatakeyama, K. and Umeda, H. ON THE INFLUENCE 

OF NITROMIN UPON IRON METABOLISM IN MOUSE. 

Gann, Tokyo, 1954, 45: 130-132. In Japanese.



145 


BIS-(Â£-CHLORO-, N-OXIDE-, â€”¿METABOLISM (IN 

CLUDING EFFECTS ON METABOLIC PROCESSES) 

(Continued) 

2552 

Â»Ishigami, K. MECHANISM OF NITROMIN ACTION. 

Arch. jap. chir., 1954, 23:516-521. Nitromin 

inhibited transaminase activity 

in neoplastic tissue but not the trans 

aminase of normal rabbit or guinea pig 

liver. 

2553 Shimizu, T. THE MODE OF ACTION OF NITROGEN 

MUSTARD N-OXIDE ON VARIOUS ENZYMES. Nagoya 

J. M. Se., 1952, 15^: 159-164. 22 refs. 

See 

3359 3379 

RESISTANCE TO 

2553a 

Hirono, I. SOME PROPERTIES OF YOSHIDA SARCOMA 

CELLS RESISTANT TO METHYL-BIS-(/Â»-CHLORETHYL)- 

AMINE N-OXIDE. Proc. Soc. Exp. Biol., N Y , 

1955, 88: 147-149. 

THERAPY 

2554 

Consoli. G. LE AZOIPRITI OSSIGENATE NELLA TERA 

PIA DELLE EMOPATIE MALIGNE. [OXYGENATED NITRO 

GEN MUSTARDS IN THE THERAPY OF MALIGNANT 

BLOOD DISEASES.] Gazz. med. ital., 1954, 113; 

359-397. 150 refs. Detailed case histories" 

of 21 treated patients. 

2555 Consoli, G. IL CLORIDRATODI METIL-BIS-O3 - 

CLOROETID-AMIN-N-OSSIDO NELLATERAPIA DELLE 

EMOPATIE MALIGNE. [METHYLBIS-0* -CHLORO- 

ETHYDAMINE HYDROCHLORIDEN-OXIDE IN THE 

TREATMENTOF MALIGNANTHEMOPATHIES.] Gior. 

ital. chemioter., 1954, 1: 154-156. Abstrac 


No. 3186. 

Â¿555a 

Fukutome, T. ON THE TREATMENTOF PULMONARY 

CANCERWITH NITROMIN. Gann, 

44: 372-374. In Japanese. 

Tokyo, 1953, 

2556 

Gori, R. M., Perea,,J. J. and Guglielmone, P. L. 

TRATAMIENTO DEL CANCER GENITAL AVANZADO CON 

MOSTAZA NITROGENADA POR VIA INTRAARTERIAL. 

[INTRA-ARTERIAL NITROGEN MUSTARD THERAPY OF 

ADVANCED GENITAL 

amer., 1954, 12: 


574-575. 

Obst. gin. lat. 

2557 

Hamashrma, Y. and Saeki, S. AN AUTOPSY CASE 

OF STOMACH CARCINOMA DIRECTLY INJECTED WITH 

NITROMIN FOR THERAPY. Gann, Tokyo, 1954, 

45: 541. In Japanese. 

2558 

Katsunuraa, S. CLINICAL APPLICATION TO CANCER 

CHEMOTHERAPY OF NITROGEN-MUSTARD N-OXIDE. 


2559 Kawamura, H. and Itano, T. NITROGEN MUSTARD N- 

OXIDE; AN AUTOPSY CASE OF RETICULOSARCOMATOSIS 

TREATED WITH NITROGEN MUSTARD N-OXIDE. Gann, 


2560 

Kimura, K., Torigoe, H., Ota, K. and Torii, S. 

NITROGEN MUSTARD N-OXIDE IN THE TREATMENT OF 

LEUKEMIA. Nagoya J. M. Se., 1952, 15: 244- 

259. 10 refs. 

2561 

Koyama, Y., Kumatori, T. and Takemasa, Y. TREAT 

MENT OF MALIGNANT TUMORS, ESPECIALLY WITH 

NITROMIN 

374-376. 

AND TEM. Gann, 

In Japanese. 

Tokyo, 1953, 44: 

2562 

Kuroyanagi, S. A CASE OF CHRONIC MYELOGENOUS 

LEUCAEMIA TREATED WITH NITROGEN MUSTARD N- 

OXIDE. Gann, Tokyo, 1953, 44: 397-398. 

In Japanese. 

2563 

Murakami, K., Hashimoto, N. and Tashiro, M. A 

DISSECTED 

BY XA-2. 

CASE OF LYMPHOSAHCOMATOSIS TREATED 

Gann, Tokyo, 1952, 43: 318-319. 

2564 

Osato, S. and Oda, K. ON THE CHEMOTHERAPY OF 

CARCINOMA. Gann, Tokyo, 1953, 44: 346-348. 

3 refs. (In English.) 

2565 

Otsuki, K. and Iwai, Y. ABOUT THE TREATMENT OF 

MALIGNANT TUMOR BY NITROGEN-MUSTARD N-OXIDE 

[METHYL-BIS (a -CHLOROETHYL)-AMINE-N-OXIDE 

HYDROCHLORIDE]. Gann, Tokyo, 1952, 43: 175- 


2566 

Shinagawa, S., Nakajima, M. and Taguchi, K. 

INHIBITORY INFLUENCE OF NITROGEN MUSTARD 

UPON THE BIOLOGICAL PREGNANCY TEST (THE 

TOAD SEMEN EXCRETION TEST) AND ON THE 

CHORIONEPITHELIOMA. Gann, Tokyo, 1953, 

44: 369-372. 5 refs. In Japanese, 

({alignant chorionepithelioma in 5 cases 

was treated with nitromin in conjunction 

with hormone therapy. One patient died; 

in one case the vaginal metastasis dis 

appeared and the excretion of the urinary 

chorionic gonadotrophic hormone changed 

to negative after the use of 150 mg nitro 

min alone. 

25S7 Tasaka, S., Nitta, J., Otani, A. and Uchiyama, 

M. FURTHER CLINICAL 

TARD N-OXIDE. Gann, 

STUDY ON NITROGEN MUS 

Tokyo, 1953, 44: 376-377. 

In Japanese. 

2568 Tasaka, S., Tomizuka, Y., Nitta, J., shikama, 

S., Kazato, Y., Otani, A. and Tamaki. T. 

CLINICAL STUDIES ON NITROGEN MUSTARD N-OXIDE 

Gann, Tokyo, 1952, 43: 169-171. In Japanese 

See 

713TOXICITY2400 

2545 

2569, 

Saku rai, Y. and Matsui, E. EFFECT OF SOME 

SULFHYDRYL CONTAINING COMPOUNDS ON NITROGEN 

MUSTARD N-OXIDE INDUCED LEUKOPENIA. Gann, 


2570 Satoh, H., Imamura, H. and Nanba, T. STUDIES 

ON THE TOXICITY OF "NITROMIN." II. Gann, 

Tokyo, 1954, 45: 516-518. 2 refs. In 

Japanese . 

2571 

Seligman, A. M. , Friedman, O. M. and Rutenberg, 

A. M. DISTRIBUTION STUDIES IN MICE FOLLOWING 

INTRAVENOUS INJECTION OF METHYL-BIS (Â£-IODO- 

ETHYL)AMINE HYDROCHLORIDE PREPARED WITH RADIO 

ACTIVE IODINE. Cancer, N. Y., 1950, 3: 342- 

347. 19 refs. 

See 

2124 

NITROGEN MUSTARDS. ETHYLAMINE, 0-NAPHTHYL 

BIS-03-CHLORO-, â€”¿ THERAPY 

2572 

Badosa Gaspar, J. and Maroto Holleda, J. 

POSIBILIDADES ACTUALES EN EL TRATAMIENTO DE 

LA LINFOSARCOMATOSIS. [CURRENT POSSIBILITIES 

IN THERAPY OF LYMPHOSARCOMATOSIS.] Rev. 

espaÃ±. enferm. ap. digest., 1954, 13: 404- 

6. Positive results were obtained~Tn one 

case of lymphosarcoma treated with naphthylchlorine.



146 

NITROGEN MUSTARDS. ETHYLAMINE 0-NAPHTHYL 

BIS-(|3-CHLORO-, â€”¿ THERAPY (Continued) 

2573 Bertola, A. SULL1 ATTIVITÃ€ TERAPEUTICA DEI 

COMPOSTI CLOROETIL-NAFTILAMINICI NELLE LEU 

CEMIE. [THERAPY OF LEUKEMIA WITH CHLORO- 

ETHYL-NAPHTHYLAMINE COMPOUNDS]. Gazz. med. 

ital., 1951, 110: 334-339. 3 refs. Six 

case histories. 

2574 

Branco, F. A TERAPEUTICA DA DOENCA DE HODGKIN- 

STERNBERG; MOSTARDA NITROGENADA: R-48; TRI- 

ETILENAMELAMINA. [THERAPY OF HODGKIN-STERN- 

BERG DISEASE; NITROGEN MUSTARD; R-48; TRI- 

ETHYLENE MELAMINE.] Clin, contemp., Lisb., 

1951, 5j 187-205. 

2575 

Calaresu, I. and Traghi, A. SUL TRATTAMENTO 

DEL MORBO DI BODGKIN COI COMPOSTI NAFTILAMINICI. 

[TREATMENT OF HODGKIN'S DISEASE WITH NAPHTHYL 

AMINE COMPOUNDS]. 

71-74. 

Athena, Roma, 1952, 18: 

2576 

De Blasiis, M. TERAPIA NAFTILAMINICA IN 

ALCUNE EMOLINFOPATIE (CONTRIBUTO CLÃ•NICO). 

[NAPHTHYLCHLORAMINE THERAPY IN SOME DISEASES 

OF THE BLOOD AND THE LYMPHATIC SYSTEM.] 


649. 9 refs. 

2577 

De Ritis, F. and Negroni, G. ATTIVITÃ€ DI UN 

COMPOSTO NAFTILAMINICO (CLORONAFTINA) IN UN 

CASO DI LEUCEMIA LINFATICA CRONICA. [ACTION 

OF NAPHTHYLAMINE COMPOUND (CHLORONAPHTHENE) 

IN A CASE OF CHRONIC LYMPHATIC LEUKEMIA.] 

Minerva ned., Tor., 1951, 42: pt. 1, 75-79. 

7 refs. 

2578 

Galton, D. A. G. AROMATIC NITROGEN MUSTARDS 

IN THE 

TO R48 

RETICULOSES; WITH SPECIAL REFERENCE 

[DI(2-CHLOROETHYL)-/* -NAPHTHYLAMINE] 

Brit. J. Radiol., 1951, 24: 511-513. 3 refs. 

"H48 is less active than nitrogen mustard; 

it acts more slowly and remissions are less 

frequent, less complete and of shorter dura 

tion than those induced by nitrogen mustard 

...it does not cause nausea and vomiting." 

2579 

Gardikas, C. and Wilkinson, J. F. TRIAL OF 

NAPTYL-DI-2-CHLOROETHYLAMINE IN LEUKAEMIA, 

HODGKIN'S DISEASE AND ALLIED DISORDERS. 

Lancet, Lond., 1951, 1: 137-139. 8 refs. 

2580 InnÃ©s, J. and Rider, *. D. MULTIPLE MYELOMA- 

TOSIS TREATED WITH A COMBINATION OF URETHANE 

AND AN ORAL NITROGEN MUSTARD. Blood, Bait., 

1955, 10: 252-258. 8 refs. 

2S81 Introzzi, P. and Ninni, M. LA CLORONAFTILAMINA 

NEL TRATTAMENTO DEL LINFOGRANULOMA MALIGNO E 

DELLE LEUCEMIE CRONICHE. [CHLORONAPHTHYLAMINE 

IN THE TREATMENT OF MALIGNANT LYMPHOGRANULOMA 

AND CHRONIC LEUKEMIA.] Haematologica, Pavia, 


Iversen, K. and Meulengracht, E. ORAL TREAT 

MENT OF POLYCYTHAEMIA VERA WITH /3 -NAPHTHYL- 

DI-2-CHLOROETHYLAMINE (R48). Brit. M. J., 

1951, 2: 510-513. 9 refs. 

2583 Iversen, K. and Meulengracht, E. PERORAL BE- 

HANDLING AF POLYCYTAEMIA VERA MEDft -NAPHTYL- 

DI-CHLORAETYLAMIN. [PERORAL /* -NAPHTHYL 

DICHLOROETHYLAMINE THERAPY OF POLYCYTHEMIA 

VERA.] Nord, raed., 1952, 47: 937-938. 

Essentially the same as article in Brit. M. 

J., 1951, No. 4730, 510-513. 

2584 

Iversen, K. and Meulengracht, E. PERORAL BE- 

HANDLING AF POLYCYTAEMIA VERA MED fl-NAPHTYL- 

DI-CHLORAETHYLAMIN (R 48). [PERORAL TREAT 

MENT OF POLYCYTHAEMIA VERA WITH P-NAPHTHYL- 

DICHLOROETHYLAMINE.] Nord. Med., 1951, 45: 

762-765. 9 refs. English summary. AbsÃ®Facted 


1680. 

2585 

Marcus, R., Black, T. and Parry, T. E. XÃŽ -NAPH- 

THYL-DI-2-CHLOROETHYLAMINE IN MULTIPLE MELANO- 

MATOSIS. Lancet, Lond., 1952, 262: 764-765. 

3 refs. Abstracted in: Chem. ABsTr., 1952, 

46: 6269b. 

2586 Matthews, W. B. A TRIAL OF ft -NAPHTYL-DI-2- 

CHLORO-ETHYLAMINE (R48) IN LEUKAEMIA, HODGKIN'S 

DISEASE AND ALLIED DISEASES. Lancet, Lond., 

1950, \\ 896-899. 7 refs. 

2587 

Melandri, F. and Patroncini, F. SUI RISULTATI 

DI UNA PROLUNGATA TERAPIA CON CLORONAFTINA 

IN UN CASO DI RETOTELSARCOMA; NOTA PREVENTIVA. 

[RESULTS OF PROLONGED TREATMENT WITH CHLORO- 

NAPHTHYNE IN A CASE OF RETICULUM CELL SARCOMA ; 

PRELIMINARY 

114: 78-82. 

NOTE]. Gazz. 

24 refs. 

med. ital., 1955, 

2588 Parreira, F. and Bertelli, G. CONTRIBUICAO 

PARA O ESTUDO DA TERAPÃÛTICA PELA CLORO 

NAFTINA NAS HEMOPATIAS. [CONTRIBUTION TO 

THE THERAPY OF BLOOD DISEASES WITH ft- 

NAPHTHYL-DI (2-CHLOROETHYL)AMINE THERAPY.] 

Clin, contemp., Lisb., 1951, 5: 259-266. 

54 refs. 

2589 Pedro-Pons, A. and Pedro-Botet, J. NUEVOS PRO 

GRESOS EN LA TERAPÃ‰UTICA CON LAS MOSTAZAS 

NITROGENADAS. (NUESTRA EXPERIENCIA EN EL TRA 

TAMIENTO CON LA BIS-2-CLORETIL-/9 -NAFTILAMINA 

(R-48). [RECENT IMPROVEMENT IN TREATMENT WITH 

NITROGEN-MUSTARD. 

BIS-2-CHLORETHYL-/* 

RESULTS OF TREATMENT WITH 

-NAPHTHYLAMINE (R-48).] 

Med. clin., Barcelona, 1954, 22: 83-97. 13 

refs. 

2590 

Piper, J. POLYCYTAEMIA VERA BEHANDLET MED 

ÃŸ-NAFTYL-DI-CHLORAETYLAMIN (TABL. ERYSAN). 

[TREATMENT OF POLYCYTHEMIA VERA WITH ft - 

NAPHTHYLDICHLORETHYLAMINE (ERYSAN).] 

med., 1954, 51: 303-305. 5 refs. 

Nord, 

2591 

Fliehet, A. LE TRAITEMENT PAR VOIE BUCCALE 

DE LA POLYCYTHAEMIA VERA (MALADIE DE VAQUEZ) 

PAR LE BÃ‰TA-NAPHTHYL-DI-2-CHLOROÃ‰THYLAMINE. 

[ORAL TREATMENT OF POLYCYTHAEMIA VERA BY 

BETA-NAPHTYL-DI-2-CHLOROETHYLAMINE.] Presse 

mÃ©d., 1952, 60: 707. A review. 

2592 

Polimeni, R. LA CLORONAFTINA NEL TRATTAMENTO 

DEL GRANULOMA MALIGNO; VANTAGGI DI UNA SUA 

SOMMINISTRAZIONE RETTALE. [CHLORONEPHTHYNE 

IN THE TREATMENT OF MALIGNANT GRANULOMA; 

ADVANTAGE OF RECTAL THERAPY.] Riv. pat. 

clin., 1951, 6: 321-330. 8 refs. 

2593 Ramioul, H. CONTRIBUTION A L'ETUDE D'UN NOU 

VEAU DÃ‰RIVEDE L'YPERITE Ã€ADMINISTRATION 

ORALE ET INTRAMUSCULAIRE: LE BIS-(2-CHLORO- 

ETHYL) Â£ -NAPHTYLAMINE DANS LES MALADIES 

CANCEREUSES. [A NEW DERIVATIVE OF MUSTARD 

GAS FOR ORAL AND INTRAMUSCULAR ADMINISTRA 

TION: BIS-(2-CHLOROETHYL) ÃŸ -NAPHTHYLAMINE 

IN CANCER.] Acta clin. belg., 1954, 9: 401- 

463. 66 refs.



147 

NITROGEN MUSTARDS. ETHYLAMINE /3-NAPHTHYL 

BIS-(ÃŸ-CHLORO-7 â€”¿ THERAPY (Continued) 

2594 Ramioul, H. INDICATION DE L'UTILISATION DE LA 

/a -NAPHTYL-DI-2-CHLOROETHYLAMINE, DANS LA 

MALADIE DE HODGKIN ET LA LEUCÃ‰MIE. 

OF/* -NAPHTYL-DI-2-CHLOROETHYLAMINE 

[THE USE 

IN 

HODGKIN'S DISEASE AND LEUKEMIA.] Acta UniÃ³ 

internat, cancr., Louvain, 1E55, 11: 167-169. 

9 refs. 

2595 

Ramioul, H. RECHERCHE DES INDICATIONS DE LA 

BIS(2-CHLOROÃ‰THYL)BETA-NAPHTYLAMINE EN CHIMIO 

THÃ‰RAPIE ANTICANCÃ‰REUSE. [RESEARCH ON INDI 

CATIONS 0F BIS(2-CHLOROETHYL)BETA-NAPHTHYL- 

AMINE IN ANTICANCEROUS CHEMOTHERAPY.) Rev. 

mÃ©d. LiÃ¨ge, 1954, 9: 706-713. 

2596 

Spigliati, P. I COMPOSTI NAFTILAMINICI NELLA 

TERAPIA DI ALCUNE GRAVI EMOLINFOPATIE. 

ULTERIORE CONTRIBUTO CLÃ•NICO. [TREATMENT OF 

CERTAIN SEVERE DISEASES OF THE HEMATOPOIETIC 

SYSTEM WITH A NAPHTHYLAMINE DERIVATIVE. 

FURTHER CLINICAL CONTRIBUTION.] 

Tor., 1950, 41: pt. 2, 490-497. 

Minerva 

4 refs. 

med., 

2597 Spigliati, P. L



148 

NITROGEN MUSTARDS. ETHYLAMTNE TRIS-(|3- 

CHLORO-, â€”¿METABOLISM (INCLUDING 


(Continued) 

2611 

Hutchens, J. 0., Podolsky, B. and McMahon, T. M. 

EFFECTS OF TRIS-(Â¿ -CHLOROETHYL) AMINE ON 

RESPIRATION, CARBOHYDRATE AND PROTEIN SYN 

THESIS AND CELL DIVISION IN CHILOMONAS. Fed. 

Proc., Bait., 1948, 7: 59. 

2611Â» 

Landing. B. 11 , Seed, J. C. 

THE EFFECTS OF A NITROGEN 

and Banfield. W. G. 

MUSTARD [TRIS(2- 

CHLOROETHYL)AMINE] ON REGENERATING HAT LIVER. 


Abstracted in: Chem. Sbstr., 1950, 44: No. 

2655f. 

2612 

Lang, K., Siebert, G. and Lucius, S. ÃœBER DIE 

HEMMUNG DER ARGINASE DURCH STICKSTOFFLOST. 

[INHIBITION OF ARGINASE BY NITROGEN MUSTARD.] 


Liver arginase is completeTy inhibited by 

methyl tris-(/8 -chloroethyl)amine hydrochloride 

at a final concentration of 4.6 x 10-4 u. 

2613 

Ludewig, S. and Chanutin, A. CHEMICAL CHANGES 

IN RAT ADRENALS AFTER INJECTION OF /S- CHLORO 

ETHYL VESICANTS. Endocrinology, 1946, 38: 

376-384. 13 refs. 

2614 

Ludewig, S. and Chanutin, A. CHOLESTEROL STUDIES 

OF ADRENALS AND PLASMA IN PARTIALLY HEPATECTO- 

MIZED AND PARTIALLY NEPHRECTOMIZED RATS AFTER 

INJECTION OF TRIS(/J -CHLOROETHYL)AMINE (HN3) . 

Endocrinology, 1948, 42: 352-355. 10 refs. 

"No significant changes in the plasma choles 

terol concentrations or adrenal hypertrophy 

can be attributed directly to HN3 in either 

partially hepatectomized or partially nephrectomized 

rats." 

2615 

Philips, F. S., Oilman, A., Koelle, E. S., 

McNamai'a, B. P. and Allen R. P. WATER AND 

ELECTROYTE BALANCE 

NITROGEN MUSTARD. 

IN DOGS INTOXICATED WITH 

Am. J. Physiol., 1948, 

155: 295-308. Abstracted in: Chem. Abstr., 

I9Ã•9, Â«: 3112a. 

2C16 

Tetzner, E. POSITIVE ABDERHALDENSCHE ABBAUFER 

MENT-REAKTION (A.B.) NACH STICKSTOFFLOST 

(SINALOST). [POSITIVE ABDERHALDEN PROTECTIVE- 

ENZYME REACTION AFTER THE USE OF NITROGEN MUS 

TARD (SINA LOST).] Zschr. Krebsforsch., 1951, 


AEstr., 1952, 46: 4650Ã•. 

See 

2215MODE OF ACTION 

2617 

Plichet, 

TIONS A. LE TRAITEMENT DE CERTAINES AFFEC 

NEOPI.ASIyl'ES PAR LES COMPOSÃ‰SAZOTÃ‰S 

DE L'YPERITE OU GAZ MOUTARDE. [THE TREAT 

MENT OF CERTAIN NEOPLASTIC DISEASES WITH 

NITROGEN MUSTARD OR MUSTARD GAS DERIVATIVES.] 

Presse ned., 1947, 55: 587. 9 refs. A re 

view. 

1964 2304 3237 

PHARMACOLOGICAL 

AND PHYSIOLOGICAL EFFECTS 

2618 Cordier, D. and Cordier, G. ACTION DE LA TRI- 

CHLOROTRIÃ‰THYLAMINE(YPÃ‰RITEA L'AZOTE) SUR 

LES GLANDES SALIVAIRES. VARIATIONS DE LA 

COMPOSITION CHIMIQUE DE LA SALIVE. [EFFECT 

OF TRICHLOROTRIETHYLAMINE (NITROGEN MUSTARD) 

ON THE SALIVARYGLANDS. VARIATIONS IN CHEMI 

CAL COMPOSITIONOF SALIVA.] C. rend. Soc. 

biol., 1949, 143: 1079-1080. Abstracted in: 


2619 

Philips, F. S., Hopkins, F. H. and Freeman, 

M. L. H. EFFECT OF TRISCO -CHLOROETHYL)AMINE 

ON ANTIBODY-PRODUCTION IN GOATS. J. Immun., 

1947, 55: 289-296. 

2620 

Smahel, 0. and Smahelova, R. VLIV DUSIKATÃ‰HO 

YPERITU NA TVORBU PROTILATEK. [THE EFFECT 

OF NITROGEN MUSTARD ON ANTIBODY FORMATION.] 

Cas. lek. cesk., 1952, 91_: 733-735. 13 refs. 

TS 160 reduced the number of lymphocytes, 

and reduced the titer of the antibodies. 

THERAPY 

2621 

Almeida, R. M. and SÃ¡enz MartÃn, P. LEUCEMIA 

MIELOIDE CRONICA TRATADA CON MOSTAZA NITRO 

GENADA. [CHRONIC MYLOID LEUKEMIA TREATED 

WITH NITROGEN MUSTARD.] Medicina, Madr., 

1949, 1JT: 380-383. Survey of the literature 

on the use of nitrogen mustard in leukemias. 

One case history. 

2622 

Billerbeck, K. PATHOLOGISCH-ANATOMISCHE UND 

PATHOPHYSIOLOGISCHE BETRACHTUNGEN ZU EINER 

SINA-LOST-BEHANDELTEN LYMPHOGRANULOMATOSE. 

[PATHO-ANATOMICAL AND PATHO-PHYSIOLOGICAL 

CONSIDERATIONS IN A CASE OF LYMPHOGRANULO- 

MATOSIS TREATED WITH NITROGEN MUSTARD.] 

Zbl. allgs Path., 1951, 88; 24-36. 48 refs. 

Abstracted in: Excerpta med.. Sect. 5, 1952, 

5: No. 3229. 

2623 

Brettler, A. ERGEBNISSE MIT SINALOST BEI BLASEN- 

UND 

THE 

HARNRÃ–HRENTUMOREN. 

TREATMENT OF TUMORS 

[NITROGEN MUSTARD IN 

OF THE BLADDER AND 

THE URETHRA.] Zschr. Urol., 1951, 44: 415-422. 

13 refs. 

2624 

Cernik, F., Lukl, P., Prochazka, J. and Roubik, K. 

KLINICKE ZKUSENOSTI S CHLORQVAN.YM ALKYLAMINEM 

(NITROGEN MUSTARD). I. LECENI LYMFOGRANULOMU. 

[CLINICAL EXPERIMENTS WITH NITROGEN MUSTARD.. 

I. TREATMENT OF LYMPHOGRANULOMA.] Cas. lek. 

cesk., 1948, 87: 1145-1152. 13 refs. 11 

cases of HodgkTn's granuloma were treated with 

the Czech nitrogen mustard (tris-bÃªta chloroethylamine 

hydrochloride). Four to six in 

jections of 0.1 mg/kg of the nitrogen mus 

tard decrease the size of the lymph nodes and 

result in remissions up to 16 weeks. Toxic 

effects and complications followed administra 

tion of the drug. 

2625 

Curnik, F., Lukl, P., Prochazka, J..and Roubik, K. 

KLINICKE ZKUSENOSTI S CHLORQVANYlf ALKYLAMINEM 

(NITROGEN MUSTARD). II. LECHENI LEUKEMIE. 

[CLINICAL EXPERIMENTS WITH NITROGEN MUSTARD. 

II. TREATMENT OF LEUKEMIA.] Cas. lek. Ã¯esk., 

1949, 88; 339-48. 18 refs. Five cases of 

cbronic~~myelocytic, two cases of subacute 

myeloblastic and eleven cases of chronic 

lymphatic leukemia were treated with the Czech 

nitrogen mustard (tris beta chloroethylamine 

hydrochloride). Remissions lasted from six 

weeks to five months. The toxic effect on 

the bone marrow is more sudden and intense in 

nitrogen mustard than in X-ray therapy. 

Nitrogen mustard therapy was not successful 

in subacute leukemia.



149 

NITROGEN MUSTARDS. ETHYLAMINE TRIS-(0- 

CHLORO-, â€”¿ THERAPY (Continued) 

2626 

Cernik, F., Lukl, P., Prochazka, J. and Roubik, K. 

KLINICKE ZKUSENOSTI S CHLOROVANYM ALKYLAMINEM 

(NITROGEN MUSTARD). III. LECENI ERYTHREMIE. 

[CLINICAL EXPERIMENTS WITH NITROGEN MUST.ARD. 

III. TREATMENT OF ERYTHREMIA.] Cas. lek. 

cesk., 1950, 89: 421-424. 

mustard (TS 1EO~) in doses 

11 refs. Nitrogen 

of 3 mg administer 

ed intravenously to three patients 

in remissions lasting 12-14 months 

resulted 

in two 

patients. The erythrooyte count became normal 

and the size of the spleen and the liver de 

creased. Phlebothrombosis of the injected 

vein was an inevitable complication. 

2627 

Cernik, F., Lukl, P., Prochazka, J. and Vizda, J. 

KLINICKE ZHUSENOSTI S HALOGENOVANlMI ALKTLAMINY. 

V. LECENI ZHOUBNYCH NADORÃš. [CLINICAL EX 

PERIENCES WITH NITROGEN MUSTARDS.v V. THERAPY 

OF MALIGNANT TUMORS.] Cas. lek. cesk., 1952, 

91: 44-49. tab. 27 refs. English summary. 

Results obtained in 24 cases. 

2628 

Cernoch, F. HORCICNY DUSÃ•K A ZKUSENOSTI S Pfil- 

PRAVKEM TS 160. [NITROGEN MUSTARD AND EX 

PERIMENTS WITH THE PREPARATION TS 160.] 

Lek. listy, Brno, 1949, Â£: 3-7. The Czech 

nitrogen mustard TS 160,"tris(beta-chloroethyl)amine 

hydrochloride and its effect on 

the lymphatic system in 15 patients are re 

viewed. Five case histories are described 

in detail. Nitrogen mustard showed radiomimetic 

effect on lymphatic and myeloid 

leukemia, in malignant lymphogranuloma, 

sarcoma and carcinoma. Application of small 

and frequent dosage to avoid toxicity are 

recommended. Simultaneous treatment with 

nitrogen mustard and irradiation showed 

better results. 

2629 

Diethelm, L. and Gumrich, H. ERFAHRUNGEN MIT 

DER LOSTBEHANDLUNG BEI BÃ–SARTIGEN GESCHWÃœLSTEN. 

[TREATMENT 

MUSTARD.] 

OF MALIGNANT TUMORS WITH 

Beri. med. Zschr., 1950, 

NITROGEN 

1: 647- 


Sect. 5, 1952, 5: No. 463. 24 cases. 

2630 

Gardikas, C. and Wilkinson, J. F. ALKYLAMINES 

IN THE TREATMENT OF LEUKEMIA. Lancet, Lond., 

1952, 263: 161-166. 29 refs. Findings 

based on treatment of 102 patients with leu 

kemia. 

2631 

Gil y Gil, [C.] KOMBINATION VON RÃ–NTGEN 

STRAHLUNG UND STICKSTOFFLOST IN DER THERAPIE. 

[THE COMBINATION OF RADIOTHERAPY AND NITRO 

GEN MUSTARD THERAPY.] Strahlentherapie, 

1955, 9J7: 105-107. 

2632 

Holy, J. and Suenan,.M. THERAPEUTICKY VLIV 

KOMBINACE MALYCH DAVEK CHLORALKYLAMINU A 

ROENTGENOVE,THERAPIE NA BLASTOMATOSNI CHOROBY 

CHEMOPOETIKEHO SYSTEMU. [THERAPEUTIC EFFECT 

OF SMALL DOSES OF CHLORALKYLAMINES COMBINED 

WITH IRRADIATION THERAPY IN THE TREATMENT OF 

NEOPLASTIC DISEASES OF HAEMATOPOIETIC TISSUE.] 


Nitrogen mustard (TS 16DT in daily doses of 

0.04-2 mg administered to 20 patients with 

leukemias resulted in an improved blood pic 

ture, especially in one case of Hodgkin's 

disease refractory to X-ray therapy. These 

results are similar to those of radiotherapy; 

were favorable in polycythemia vera and less 

favorable in chronic leukemias. 

2633 

Howells, L. NITROGEN MUSTARD AND ITS USES IN 

THE TREATMENT OF DISEASE. Med. 

1953, 230: 87-90. 17 refs. 

Press, Lond., 

2634 

Â»KÃ¼hn,E. and Moucka, I. USPESNE LECENI MALIOSI III) 

LYMFOGRANULOMU TRI (CBLORETHYL) AMINHYDROCHLO- 

RIDEM (T.S. 160). [SUCCESSFUL 

MALIGNANT LYMPHOGRANULOMA WITH 

TREATMENT OF 

TRI-(CHLORETHYL) 

AMINOHYDROCHLORIDE (TS 160).] VoJ. zdrav. 

listy, 1951, 20: 83-85. Abstracted in: Excerpta 

med., Sect. 2~T~1952, 5: No. 2991. 

2635 

Pinker, H. and Braun, H. KRITSCHE BETRACHTUNG 

ZUR BEHANDLUNG DER LYMPHOGRANULOMATOSE 

STICKSTOFF-LOST. [CRITICAL EVALUATION 

MIT 

OF 

NITROGEN MUSTARD THERAPY OF LYMPHOGRANULOMA- 

TOSIS.] Aerztl. Wschr., 1950, 5: 207-210. 

14 refs. 

2636 

Rozabal, F., Ortiz VÃ¡zquez, J. and Ruiz FalcÃ², F. 

RESULTADOS INMEDIATOS DE LA CLORETILAMINOTERAPIA 

EN UN CASO DE ENFERMEDAD DE HODGKIN. [IMMEDIATE 

RESULTS OF CHLOROETHYLAMINO THERAPY IN ONE CASE 

OF HODGKIN'S DISEASE.] Rev. clin, espaÃ±., 1949, 

35: 403-407. 19 refs. 

2637 

Sous, l , 0. and HeÃ¯mansky, F. NASE ZKUSENOSTI 

S LÃ‰CBOU CHLORETHYLAMINY. [OUR EXPERIMENTS 

WITH NITROGEN MUSTARD TREATMENT.] Cas. lek. 

Sesk., 1948, 87: 1298-1302. 7 refs. Ten 

cases of HodgkThts disease, as well as two 

cases of chronic myeloid and two cases of 

chronic lymphatic leukemias previously un 

successfully treated with urethane showed 

improvement following treatment with Czech 

nitrogen mustard (tris-bÃªta-chloroethylamine 

hydrochloride). Nitrogen mustard treatment 

was not very successful in a bronchial and 

pleural carcinoma nor in three cases of 

various sarcomas. General toxic reactions 

were not significant, especially as the 

toxicity could be reversed with penicillin 

and transfusions. 

2638 

StÃe lee, J. LJÃ•CENÃ•ZHOUBNYCH KOSTNICH NADORU 

PRIPRAVKEM. [TREATMENT OF BONE TUMORS WITH 

NITROGEN MUSTARD.] 

6: 24-27. 16 refs. 

Lek. listy, Brno., 


1951, 

Ab 


5: No. 607. Osteosarcoma in 10 patients was 

Created with 0.1 mg nitrogen mustard. In 

2 cases the tumor became smaller but did not 

disappear completely. Transitory signs of 

apparent improvement also occurred. 

2639 Tewes, H. UEBER EINEN FALL MIT TRICHLORTRI- 

Ã„THYLAMINCHLORHYDRAT BEHANDELTER RÃ”NTGEN- 

REFRAKTÃ„RER LYMPHOGRANULOMATOSE IM HINBLICK 

AUF DIE DABEI AUFTRETENDEN VERÃ„NDERUNGEN DES 

HXMOPOETISCHEN SYSTEMS. [THERAPY OF A CASE 

OF ROENTGEN REFRACTORY LYMPHOGRANULOMATOSIS 

WITH TRICHLOROTRIETHYLAMINE HYDROCHLORIDE, 

WITH SPECIAL REGARD TO CHANGES OF HEMOPOIETIC 

SYSTEMS.] Med. Mschr., 1950, 4: 534-537. 

18 refs. 

2640 

Vesin, S. KOMBINACE MIKRODAVEK CHLORALKYLAMINU 

A OZAROVANI ROENTGENOVYMI PAPRSKY PRI LÃ‰CENÃ• 

HAEMOBLASTOS A HAEMOBLASTOMÃš. [COMBINATION 

OF MICRODOSAGE OF CHLORALKYLAMINES WITH ROENT 

GEN IRRADIATION IN THE TREATMENT OF HEMOBLAS- 

TOSES 

1952, 

AND 

91: 

HEMOBLASTOMAS.] Cas. lek. Ã„esk., 

1384-1387. English summary. 

2041 â€¢¿* *â€¢ â€ž¿ v v /Â» 

Viada, J. NASE ZKUSENOSTI S LECBOU CHLORETHYL 

AMINY. IV. LÃ‰CENÃ•BRONCHOGENNÃ•HO KARCINOMU. 

[OUR EXPERIMENTS WITH NITROGEN MUSTARD. IV. 

TREATMENT OF BRONCHOGENIC CARCINOMA.] Cas. 

lÃ©k. Ã®esk., 1950, 89: 801-803. 10 refs. 

Nitrogen mustard infections of 0.1-5 mg to 

8 patients with bronchogenic carcinoma re 

sulted in a lessening of symptoms in 4, 

regression of infiltration and atelectasis 

in 2 and no effects in 2 patients. Nitrogen 

mustard has no advantages over radiotherapy 

and should be used 

to X-ray therapy. 

only in cases refractory



150 

NITROGEN MUSTARDS. ETHYLAMINE TRIS-(0- 

CHLORO-, â€”¿ THERAPY (Continued) 

2642 Wolterhofi, B. THERAPIEVERSUCHE HIT LOST BEI 

INOPERABLEN BLASENKREBS. [THERAPEUTIC USE 

OF NITROGEN 

CARCINOMA.] 

MUSTARD 

Zschr. 

IN INOPERABLE BLADDER 

Urol., 1952, Sonderhft., 

303-307. 10 reta. 

26Zwetschke, O. MNOHOCETNY PLASMOCYTOM LÃ‰CENY 

CHLORETHYLAMINEM (TS 160). [MULTIPLE MYELO- 

MATOSIS TREATED WITH CHLORETHYLAMINE (TS 160).] 


Nitrogen mustard (TS 160T in a total of 128 

mg administered to one patient with multiple 

myelomatosis improved the pathological frac 

ture of the spine and in general improved the 

overall condition of the patient. 

See 

2007 

2268 

2332 

2353 

2401 

TOXICITY 

2125 

2269 

2343 

2365 

2412 

2126 

2286 

2347 

2371 

2434 

2129 

2299 

2350 

2385 

2446 

2267 

2304 

2352 

2389 

2482 

2644 

Braun, H. and Eicke, W. J. SYMPTOMATISCHE PSY 

CHOSE BEI STICKSTOFF-LOST-BEHANDLUNG EINER 

LYMPHOGRANULO.ATOSE. [SYMPTOMATIC PSYCHOSIS 

IN NITROGEN-MUSTARD TREATMENT OF A LYIiPHO- 

GRANULOMATOSIS.] Nervenarzt, 1955, 26: 71-73. 

Approx. 30 refs. "This represents a case of 

symptomatic psychosis with tendencies to 

anxiety and paranoia. There has not been any 

such report as a result of nitrogen mustard 

treatment nor in cases of lymphogranulomatosis." 

2645 

Fuchs, J. UEBER GEFAHREN FÃœR ARZT UND PFLEGEPER 

SONAL BEI DER VERWENDUNG VON STICKSTOFFLOST. 

[DANGERS TO PHYSICIAN AND NURSING PERSONNEL 

DURING USE OF NITROGEN MUSTARDS.] Med. Mschr., 

1949, 3: 535-536. 4 refs. Case history of 

accidental contact with HN3 (face and eye) 

during intravenous treatment of patient. 

2646 

Goldeck, H. TOXISCHE BEGLEITWIRKUNG DER 

STICKSTOFF-LOST-THERAPIE. [TOXIC SIDE EF 

FECTS OF NITROGEN MUSTARD THERAPY.] Sang, 

Par., 1950, 21: 390-394. Abstracted in: 

Chem. Abstr.7T.950, 44J No. 8544f. 

2647 

Truhaut, R. SUR L'ACTION PROTECTRICE DE LA 

j MERCAPTOETHYLAMINE VIS-A-VIS DES EFFETS 

TOXIQUES DES COMPOSÃ‰S DE LA SERIE DES MOU 

TARDES. [PROTECTIVE ACTION 0F^MERCAPTO- 

ETHYLAMINE AGAINST THE TOXIC EFFECTS OF 

THE NITROGEN MUSTARDS.] Acta UniÃ³ internat, 


See 

2448 2512 2514 

NITROGEN MUSTARDS. PROPANE DfflYDROCHLORIDE, 

1,3, -BIS[BIS(/3-CHLOROETHYL)AMINO]- 

2 Burchenal, J. H. THE NEWERNITROGENMUSTARDS 

IN THE TREATMENTOF LEUKEMIA. Radiology. 


Biol. ifstr., Bait., 1949, 23: No. 3940. 

See 

2281 

NITROGEN MUSTARDS. PYRIDINE, 3-BIS(0-CHLORO- 

ETHYL)AMINOMETHYL-4-METHOXYMETHYL-5- 

HYDROXY-6-METHYL- 

2649 

Biesele, J. J. ASSAY OF CARCINOLYTIC AND CAR- 

CINOSTATIC AGENTS. Ann. N. York Acad. Sc., 

1954. 58: 1129-1145. 24 refs. Discussion: 

p. 1145=1146. 

265U 

Stock, C. C., Buckley, S., Sugiura, K. and 

Rhoads, 

TION OF 

C. P. A COMPARISON OF THE RETARDA 

SARCOMA 180 BY SK 1424, 3-BIS 

( ÃŸ-CHLOROETHYL) AMINOMETHYL-4-METHOXYMETHYL- 

5-HYDROXY-6-METHYLPYRIDINE WITH THAT BY HN2, 

METHYL BIS (ÃŸ-CHLOROETHYL)-AMINE. Cancer 

Res., 1951, 11: 432-436. 

in: Excerpta~med., Sect. 


5, 1952, 5: No. 469. 

SK 1424 was more efficient in retarding 

Sarcoma 180 than HN2. 

2651 

Sugiura, K. and Stock, C. C. STUDIES IN A TUMOR 

SPECTRUM. I. COMPARISON OF THE ACTION OF 

METHYLBIS(2-CHLOROETHYL)AMINE AND 3-BIS(2- 

CHLOROETHYL)AMINOMETHYL-4-METHOXYMETHYL-5- 

HYDROXY-6-METHYLPYRIDINE ON THE GROWTH OF A 

VARIETY OF MOUSE AND RAT TUMORS. Cancer, 

Phila., 1952, 5: 382-402. 34 refs. 

NITROGEN MUSTARDS. URACIL, 4-METHYL-5-DI(2- 

CHLOROETHYLJAMINO- 

2652 

Larionov, L. F. and Platonov, G. N. 0 PROTIVO- 

OPUKHOLEVOM DEISTVII 4-METIL-5-DI(2-KHLORO- 

ETIL) AMINOURATSILA (DOPAN-A). [ON THE ANTI- 

TUMORAL EFFECT OF 4-METHYL-5-DI(2-CHLOROETHYL) 

AMINOURACIL.l Vopr. onkol., 1955, 1: No. 5, 

36-38. 2 refs. In mice with transplanted 

rat sarcoma 45, rat. Geren carcinoma and car 

cinoma of the mammary gland, DOPAN decreased 

the size of the transplanted tumors, regener 

ated the connective tissue of the tumor stroma 

and decreased the count of leucocytes in the 

blood and bone marrow. DOPAN is more effective 

than emblkhin and limfokhin; its effect re 

sembles most closely that of sarkolizin. 

NITROMIN 

see NITROGEN MUSTARDS. ETHYLAMINE, METHYL 

BIS-(ÃŸ-CHLORO-, N-OXIDE- 

NORMODYN 

see BLOOD EXTRACTS 

NORVALINE 

2653 Martinetto, G. AZIONE DELLA NORVALINA SÃœLL 

SVILUPPO DELL'ADENOCARCINOMA DA INNESTO. 

[EFFECT OF NORVALINE ON THE DEVELOPMENT OF 

THE TRANSPLANTED ADE NOC ARC INOMA.] Neoplasie 

Staliment., 1953, 6: 304-312. 2 refs. 

Norvaline, an amino acid, in doses up to 

300 mg per animal, inhibited tumor growth 

when injected subcutaneously into 30 male 

albino rats with transplanted adenocarcinoma, 

but had no effects on the decrease 

of body weight or the neoplastic ulcÃ©ra 

tion.



151 

NOVOCAINE 

2654 , â€ž¿ 

FedfÃ¹shin, U. P. NABLIUDENUA NAD VLIIANIEM 

OKOLOPOCHECHNOI BLOKADY NOVOKAINOM NA ROST 

I METASTAZIROVANIE OPUKHOLI BROUN-PIRS U 

KROLIKOV. [EFFECT OF RENAL NOVOCAINE BLOCK 

ON THE GROWTH AND METASTASES OF BROWN-PEARCE 

TUMORS IN RABBITS.) 

SSSR. Vopr. onkol., 

Tr. Akad. med. nauk 

1954, No. 7, 167-172. 

The Russian literature on the oncolytic ef 

fect of novocain block is reviewed. The 

results of administration of 8 ml/ kg of a 

25% solution of novocaine to 43 rabbits are 

described. While the tumor regressed and 

there were fewer mÃ©tastases no conclusive 

findings on the oncolytic effects of novo 

cain could be derived. 

NUCLEASE, RIBO 

2fi55 

Ledoux, L. ACTION OF RIBONUCLEASE ON CERTAIN 

ASCITES TUMOURS. Nature, Lond., 1955, 175: 

258-259. 7 reÃs. "Ribonuclease diffusing 

across the cell membranes had a very clear 

anti-mitotic effect...These experiments in 

volved three hundred animals carrying the 

Ehrlich or Krebs mouse carcinomata or the 

Walker rat carcinomata 256..." 

2656 

Ledoux â€¢¿doux, L. and Baltus, E. ACTION DE LA RIBO 

NUCLEASESUR LES CELLULES DU CARCINOME 

D'EHRLICH. [EFFECT OF RIBONUCLEASEON THE 

CELLS OF EHRLICH'S CARCINOMA.] Experientia, 

Basel, 1954, lOj 500-501. 8 refs. 

NUCLEIC ACIDS 

See 

10 

NUCLEIC ACIDS, DESOXYRIBO- 

Della Pietra, G. and Quagliariello, E. INIEZIONI 

DI ACIDI DEOSSIRIBONUCLEINICI ESTRATTI DA 

TESSUTI DI ORIGINE MESODER1IALE DI RATTO NORMALE 

IN SARCOMA DA BENZOPIRENE DEL RATTO. [INJEC 

TIONS OF DEOXYRIBONUCLEIC ACID EXTRACTS FROM 

THE MESODERMALTISSUE OF RATS(NORMAL) INTO 

THE BENZOPYRENE SARCOMA OF RATS.] Boll. Soc. 

ital. biol. sper., 1952, 28: 1303-1304. 

2fi58 Deotto, R. ACTION OF NUCLEIC ACIDS ON CELLULAR 

MULTIPLICATION. Acta UniÃ³ internat, cancr., 

Louvain, 1954, 1Â£: 117-118. 

NUCLEIC ACIDS, RIBO 

2659 

Deotto, R. and Neceo, A. AZIONE DEGLI ACIDI 

NUCLEINICI SULLA MOLTIPLICAZIONE CELLULARE; 

AZIONE DEGLI ACIDI NUCLEINICI SULLA MOLTI 

PLICAZIONE "IN VITRO" DEI FIBROBLASTI DA 

EMBRIONE DI POLLO. [EFFECT OF NUCLEIC ACIDS 

ON CELLULAR MULTIPLICATION; IN VITRO EFFECT 

OF THE NUCLEIC ACIDS ON FIBROBLASTS OF 

CHICKEN EMBRYO.] 

129-131. 1 rÃ©f. 


Ribonucleic and 

1952, 3Â£: 

desoxyribonucleic 

acids inhibit fibroblast mitosis 

in vitro. 

2660 

Deotto B. AZIONE DEGLI ACIDI NUCLEINICI SULLA 

MOLTIPLICAZIONE E SULLA RESPIRAZIONE CELLULARE; 

AZIONE DEGLI ACIDI NUCLEINICI SULLA RESPIRA 

ZIONE DEI TESSUTI NEOPLASTICI. [EFFECT OF 

NUCLEIC ACIDS ON CELLULAR MULTIPLICATION AND 

RESPIRATION; EFFECT ON NEOPLASTIC TISSUE.] 


Ribonucleic and deoxyrlBonucleic acids ap 

pear to lower the consumption of 0Â¿ by the 

Ehrlich adenocarcinoma in rats. 

OJima, T. and Ogaki, M. EFFECT OF SODIUM RIBOSE 

NUCLEATE ON MEIOSIS OF GRASSHOPPERS. Nature, 

Lond., 1950, 165; 895. 2 refs. 

See 

2658 

NUCLEOSIDES 

2661 

Biesele, J. J., Berger, R. E. and Clarke, M. 

ANTAGONISM STUDIES WITH SEVERAL TOXIC PURINES 

AND FURINE NUCLEOSIDES IN MOUSE TISSUE CUL 

TURES. Cancer Res., 1952, 12: 465-470. 

1 pi. 19 refs. AbstractedTn: Chem. Abstr., 

1952, 46: No. 10443ÃŒ. 

2662 

Biesele, J. J., Berger, R. E. and Clarke, M. 

TISSUE CULTURE SCREENING OF PURINES AND PURINE 

NUCLEOSIDES FOR SELECTIVE DAMAGE TO MOUSE 

SARCOMA CELLS. Cancer Res., 1952, 12: 399- 

406. 38 refs. 1 pi. "ComparÃ¢tive~Ebxic ef 

See 

fects of 96 purines and 28 purine nucleosides 

on embryonic mouse skin cells and Crocker 

mouse Sarcoma 180 cells in tissue culture are 

reported. The most effective compounds were 

certain 2-substituted adenines, particularly 

2-chloroadenine, 2,6-diamino-purine, 2-methyladenine, 

2-iodoadenlne and certain 2,6-diamino- 

8-arylpurines. Purine nucleosides, with the 

major exception of 2-hydroxyadenosine, tended 

to be less toxic to Sarcoma 180 cells than 

the corresponding free purines." 

2947 

NUCLEOTIDES (PENTOSE) AND RELATED 

COMPOUNDS 

2663 

Barakan, T. H., Barker, G. R., Guiland, J. M. 

and Parsons, L. D. TISSUE CHANGES IN MICE 

TREATED WITH PENTOSE NUCLEOTIDES AND RELATED 

COMPOUNDS. J. Path. Bact., Lond., 1948, 60: 

441-459. 21 refs. CBA and C57 mice with 

methylcholanthrene sarcoma were used. Adenylic 

acid and guanylic acid inhibited tumor growth, 

cytidylic acid had slight effect and uridylic 

acid promoted growth. Adenosine diminished 

growth while uracil and uridine increased 

tumor development. 

2664 

Barker, G. R., Gulland, J. M. and Parsons, L. D. 

TISSUE CHANGES IN EXPERIMENTAL MICE TREATED 

WITH PENTOSE NUCLEOTIDES. Nature, Lond., 

1946, 157: 482-483. 10 refs. 

2665 Parsons, L. D., Gulland, J. M. and Barker, G. R. 

TISSUE CHANGES IN MICE TREATED WITH PENTOSE 

NUCLEOTIDES. Sympos. Soc. E*p. Biol., Cambr., 

1947, U 179-189. 29 refs. 

Revol, L. DE L'INTÃ‰RÃŠTPOSSIBLE DES NUCLEOTIDES 

PENTOSIQUES DANS LE TRAITEMENT DES LEUCOSES 

AIGUÃ‹S. [POSSIBLE VALUE OF PENTOSE NUCLEOTIDES 

IN TREATMENT OF ACUTE LEUKEMIA.] Lyon mÃ©d., 

1953, 189: 167-170. Intramuscular injections 

of 5-lD~51, 7% solution of pentose nucleotides 

in 3 patients with acute leukemia resulted in 

the normalizing of the myelogram, reduction 

in fever as well as transitory remissions. 

OEDIUM 

see FUNGI 

OMAIN 

ALBICANE 

see COLCHICINE, 

DESACETYL_



152 

ORGAN EXTRACTS 

Domagk, G. and Hackmann, C. DIE ZUSÃ„TZLICHE 

BEHANDLUNG BÃ–SARTIGER GESCHWÃœLSTE DURCH 

STEIGERUNG DER TUMORSPEZIFISCHEN ABWEHRAKTIVITÃ„T. 

[COMPLEMENTARY TREATMENT OF MALIGNANT TUMORS BY 

INCREASE OF THE SPECIFIC DEFENSIVE ACTIVITY 

AGAINST THE TUMOR.] Zschr. Krebsforsch., Beri., 

1953, 59: 2-10, 5 refs. The use of an immune 

organ extract (H 4989) is recommended as com 

plementary treatment in patients with malig 

nancies. Experiments with this substance and 

immune liver extract on Walker carcinoma of 

the rat are described. 

"fort N pftEDBÃ‹ZNAZPRÃ‚VA O POUZITI PftlPRAVKU 

RTN PÂ¿I LÃ‰CBÃ‹ZHOUBNYCH NADORU. [PRELIMINARY 

REPORT ON THE USE OF THE SUBSTANCE RTN IN 

TREATMENT OF MALIGNANT TUMORS.] Cas. lek. 

Ã²esk 1949, 88: 1195. The substance was 

tested on 73 patients with different tumors. 

Best results were achieved in gynecological 

tumors. General improvement occurred. 

7 patients died so far. 

2669 HoleSek, V. KLINICKE ZKUSENOSTI S PRAPARATY 

RTN. [CLINICAL EXPERIENCE WITH RTN.] Cas. 

lek cesk., 1949, 88: 1193-1194. Up to 30 

intramuscular and subcutaneous injections 

1-2 weekly were given to patients with 

various tumors. Best results were achieved 

in gynecological cancer, whereby a diminish 

ing of mÃ©tastases was observed. 

261Irbanek G PRÃ•SPÃ‰VEKK BÃ•DÃ•NÃ•O TUMORECH. 

CASTin*. 

fcoNTRiBUTiOHTOTUMOUR RESEARCH.] 

Â¿as. lek. cesk., 1949, 88: 1187-1193. English 

summary: p. 1197. In thTs third report of a 

three-part study the organic extract desig 

nated as RTN is discussed. Subcutaneous and 

intramuscular injections from 0.3-50 mg given 

1-3 times weekly to patients with different 

tumors decreased the mÃ©tastases, decreased 

the leucocyte count and in some cases almost 

completely inhibited the growth of the tumor. 

2671 

Venta, J. ZKUSENOSTI S PREPARATEM RTN, [EX- 

PERÃ•ENCES WITH THE RTN SUBSTANCE.] Cas. lek. 

cesk., 1949, 88: 1194-1195. The extract was 

tested on 47 patients with cancer in the 

lower regions of the body over a period of 

3-10 months. Improvement in the overall con 

dition of the patients and some decrease in 

the size of the tumors occurred. 

2672 Zicha, O., UrbÃ¡nek, G. and Zicha, K. PRISPEVEK 

K BÃ•DANÃ•0 TUMORECH. I. CAST. JCONTRIBUTION 

TO TUMOR RESEARCH. I. PART.] Cas. lek. cesk., 

1947, 86: 1341-1345. 

port ol~~a three-part 

2 pi. In this first re 

study organic extracts 

as cancerolytic agents are described. The ex 

tracts were obtained from the normal tissue of 

brain, spleen, thymus, bone marrow, liver and 

pancreas and were 

and carcinomas as 

used 

well 

in experimental sarcomas 

as benign tumors. Histological 

tests showed nucleic destruction of 

the tumor cells, in some instances 2-3 minutes 

following application of extract. Iron, 

quinine and NaCU promote lysis of tumor cells 

whereas nicotine, caffein, thÃ©ine and vinegar 

reduce lysis. 

ORGANOMETALLIC COMPOUNDS 

QC'TO 

Geschickter, C. F. ADMINISTRATION OF OIL- 

SOLUBLE ORGANO-METALLIC COMPOUNDS IN LEUKEMIA. 

Bull. Georgetown Univ. M. Cent., 1947-1948, 

1: 19-27. 2 refs. 

^Geschickter , C. F. and Reid, E. E. ADMINI 

STRATION OF OIL-SOLUBLE ORGANOMETALLIC 

COMPOUNDS IN MALIGNANCY. In: APPROACHES 

TO TUMOR CHEMOTHERAPY. Wash., Am. Ass. 

Advance. Sc., 1947, p. 431-442. 16 refs. 

2675 

LettrÃ©, H. and Lettre, R. AUFHEBUNG DER MITO 

SEGIFTWIRKUNG METALLORGANISCHER VERBINDUNGEN. 

[ANTAGONISM OF THE ANTIMITOTIC ACTION OF 

ORGANOMETALLIC COMPOUNDS]. Naturwissenschaften, 

1947, 34: 127. 8 refs. Abstracted in: Chem. 

Abstr., 1948, 42: 4270h. 

See 

787 

OVARIES. 

EXTRACT 

2676 Heilbrunn, L. V., Wilson, W. L. and Harding, D. 

THE ACTION OF TISSUE EXTRACTS ON CELL DIVI 

SION. J. Nat. Cancer Inst., 1951, 11: 1287- 

1298. 18 refs. 

OXYCHLORINE 

2677 

Â»Consoli, G. IL TRATTAMENTO CITOSTATICO DELLE 

EMOPATIE MALIGNE CON LE OSSICLORINE. [OXY 

CHLORINE IN CYTOSTATIC THERAPY OF MALIGNANT 

BLOOD DISEASES.] Minerva raed., Tor., 1955, 

46: 1386-1388. 

OXYDANS 

2fi78 

Christian!, A. DIE FERMENTHEMMSTOFFTHEORIE DES 

KREBSES UND 

DER KLINIK. 

IHR ANWENDUNGSGEBIET INNERHALB 

[THE THEORY OF AN ENZYME-BLOCKING 

SUBSTANCE OF CANCER AND ITS CLINICAL USE.] 

Krebsarzt, Wien, 1948, 3: 114-118. Discussion: 

p. 115-118. Also in: Wien klin. Wschr., 1948, 

60: 267-271. 

OXYTETRACYCLINE 

26lÂ»rnard U D and Fox, H. L. INNOCUITY OF PRO 

TRACTED Ã’RÃŒLADMINISTRATION OF SPECIAL FERMEN 

TATION CONCENTRATES OF B12 AS DEMONSTRATED IN 

A PATIENT WITH ACUTE LEUKEMIA. Ohio M. J., 

1950, 46: 784-786. 8 refs. The sustained 

clinicÃ¤T remission obtained with a daily 

dietary supplement of 240 to 320 micrograms 

of B12 may have been coincidental. A patient 

taking 100 mg of terramycin daily was entering 

the eighth month of remission. In 29 acute 

leukemic patients given antibiotics derived 

from streptomyces species 18 remissions 

occurred. 

2694 3672a 

see PANCREAS 

PANCREAS 

ManoÃ¯lov, S. E. DEÃ•STVIE BIOLQGICHESKOGO PRE- 

PARATA "P" NA INDUTSIROVANNUIU KRYSINUÃ•U 

SARKOMU [THE EFFECT OF THE BIOLOGICAL PRE 

PARATION "P" ON EXPERIMENTAL RAT SARCOMA.) 

Vopr. onkol., 1955, 1: No. 5, 39-41. 6 refs. 

The drug, obtained from cattle pancreas, 

consists of a higher active enzyme complex 

affecting albumen metabolism. Preparation 

"P" caused necrotization of experimental rat 

sarcoma, without adversely affecting the 

normal tissue.



153 

PANCREAS 

(Continued) 

2681 Manoilov, S. E. and FunshteÃ¯n, L. V. PATOLOÃ‡O- 

GISTOLOGICHESKAfÃ€ KARTINA EKSPERIMENTAL'NOI 

KRYSINOÃ• SARKOHY PRI LECHENII ZHIVOTNYKH 

BIOLOGICHESKIM PREPARATO!! "P". [PATHOLOGICAL 

PICTURE OF EXPERIMENTAL RAT SARCOMA FOLLOWING 

TREATMENT WITH PREPARATION "P".] Vopr. onkol., 

1955, 1: No. 5, 41-46. Pankreatin causes 

necrosTs of sarcomas, promotes collagen for 

mation and generally inhibits sarcoma growth 

in rats. 

PANTOTHENIC 

ACID 

2682 

Ceria, A. ACIDO PANTOTENICOE TUMORI; RICERCHE 

SPERIMENTALI. [PANTOTHENICACID ANDTUMORS; 

EXPERIMENTALRESEARCH.] Neoplasie, Tor., 1947, 

2: 234-240. 17 refs. Pantotnenic acid in 

doses of 5 mg was injected subcutaneously into 

albino rats with Ehrlich adenocarcinoma. The 

body weight decreased, the weight of the tumor 

increased and the survival time was prolonged. 

PARACELSUS 4 

see also ANTIMONY 

2683 

Hauer, A. CONSIDERAÃ‡OESOBRE A METALOTERAPIA 

DO CANCERDECLARADO. [FINDINGS IN THE METAL- 

THERAPYOF CANCER.] Brasil med., 1947, 61: 

417-422. pi. English summary. 

PARASITES 

see ANCYLOSTOMA; TRYPANOSOMA CRU ZI; TRYPANO- 

SOMA LEWIS!; PLASMODIUM; 

PATHODYN 

see BLOOD EXTRACTS 

PATULIN â€”¿ EFFECT 


2684 Vollmar, H. VERSUCHE ÃœBERDIE BEEINFLUSSUNG 

DES WACHSTUMSVON GEWEBE IN DER GEWEBEKULTUR 

DURCH PATULIN. [EXPERIMENTS ON THE EFFECT 

OF PATULIN ON THE GROWTH OF TISSUE CULTURES.] 

Zschr. Hyg., 1947, 127: 316-321. 

PELTATTN, a- AND ÃŸ- 

2685 

Greenspan, E. M . Colsky, J., Schoenbach, E. Bâ€ž 

and Shear, M. J. RESPONSE OF PATIENTS WITH 

ADVANCED NEOPLASMS TO THE INTRAVENOUS ADMIN 

ISTRATION OF ALPHA-PELTATIN. J. Nat. Cancer 

Inst., 1954, 14: 1257-1275. 2 pi. 23 refs. 

2686 

Greenspan, E. Ma, Leiter, J0 and Shear, M. J. 

EFFECT OF ALPHA-PELTATIN, BETA-PELTATIN, AND 

PODOPHYLLOTOXIN ON LYMPHOMAS AND OTHER TRANS 

PLANTED TUMORS. 

10: 1295-1333. 


9 pi. 3.1refs. 

Inst., 1950, 

2687 Law, L. W. OBSERVATIONS ON PROPERTIES OF LEU- 

KEMIC CELLS RESISTANT TO FOLIC ACID ANTAGO 

NISTS. J. Nat. Cancer Inst., 1951, III 849- 

865. 2 pi. 15 refs. 

1341 1364 2779 2820 

PENICHROMIN 

2688 

Levine, H. A., Burk, D., Dubuy, H. and Woods, M. 

THE BIOLOGICAL ACTIVITY OF PENICHROMIN, A 

PIGMENTED MATERIAL PRODUCED BY P. NOTATUM. 

Antibiotics, 1951, 1: 461-468. 7 refs. 

"Penichromin...inhibited the oxidative utili 

zation of hexosediphosphate, malate, fumarate, 

pyruvate, and isocitrate by mouse liver pre 

parations. Succinoxidase, anaerobic glycolysis, 

and cytochrome oxidase were not affected. In 

vivo testing of penichromin 

produced no regression." 

on mouse tumors 

PENICILLINâ€”EFFECT ON MALIGNANT GROWTH 

2689 Dobrovolskala-Zavadska'ia, N. L'EFFET DE LA 

PENICILLINE SUR LES TUMEURS CHEZ LA SOURIS. 

[EFFECT OF PENICILLIN ON TUMORS IN MICE.] 

Bull. Ass. fr. cancer, 1946, 33: 192-222. 

42 refs. Abstracted in: Index analyt. 

cancer., Par., 1947, 18: No. 630. 

2690 , 

Dobrovolskala-Zavadska'ia, N. LA METHODE DES 

CONTROLES INDIVIDUELS DANS LES,RECHERCHES 

BIOLOGIQUES DE TUMEURS ET SA VERIFICATION 

PAR L'ETUDE DE L'EFFET DE LA PENICILLINE. 

[METHOD OF "INDIVIDUAL CONTROL" IN BIOLOGI 

CAL TUMOR RESEARCH AND ITS VERIFICATION 

BY THE STUDY OF THE ACTION OF PENICILLIN.] 

C. rend. Soc. biol., 1946, 140: 425-427. 

6 refs. Abstracted in: Index analyt. 

cancer., Par., 1947, 18: No. 388. 

2691 Dobrovolska'ia-Zavadskaia, N. and Nekhorocheva I 

L'EFFET DE LA PENICILLINE PURIFIEE SUR LES 

TUMEURS MAMMAIRES DE LA SOURIS. [EFFECT OF 

PURIFIED PENICILLIN ON MAMMARY TUMORS OF THE 

MOUSE.] Bull. Ass. fr. cancer, 1949, 36: 


Abstr., 1952, 46: No. 640g. 

2692 

Kinkel, H. ZUM LEUKOSEPROBLEM; ZUGLEICH ZUR 

FRAGE EINER PENICILLINWIRKUNG AUF LEUKOSE 

ZELLEN. [THE PROBLEM OF LEUKEMIA; THE 

QUESTION OF THE EFFECT OF PENICILLIN ON LEU 

KEMIA CELLS.] Aerztl. Forsch., 1950, 4: 

Originalarb., 51-56. 24 refs. Abstracted 

in: Chem. Abstr., 1952, 46: 104361. "Pro 

gressive necrosis of leukemia was treated 

with penicillin (I), which caused an ex 

treme drop in the number of leukocytes. 

The para-myeloblasts dropped from 85 to 50%. 

The normally myelocytic and lymphocytic cell 

elements increased. The opinion is expressed 

that the immature, still undefined cells are 

related to certain bacteria in their primi 

tive organization and 

to I." - Chem. Abstr. 

are thus susceptible 

See 

150 1913 


2693 

AndrÃ©, R. RECHUTE ET EVOLUTJON FATALE D'UNE 

LEUCÃ‰MIE AIGUÃ‹ APRES UNE REMISSION COMPLÃˆTE 

DE TROIS ANS ET SEPT MOIS. [RELAPSE AND 

FATAL EVOLUTION OF A CASE OF ACUTE LEUKEMIA 

AFTER 

SEVEN 

COMPLETE 

MONTHS.] 

REMISSION OF 

Sang, Par., 

THREE 

1950, 

YEARS AND 

21: 833- 

838. This is essentially the same report 

as: Decourt, J., AndrÃ©, R., Guillemin, J. 

and Berthet, G. 

1950, 66: 47-50. 

Bull. Soc. med. hop. Paris,



154 

PENICILLINâ€”THERAPY 

(Continued) 

2694 

Bateman, 

Klopp, 

J. C., Barberio, J. R., 

C. T. and Pierpont, H. 

Orice, P., 

FATAL COM 

PLICATIONS OF INTENSIVE ANTIBIOTIC THERA 

PY IN PATIENTS WITH NEOPLASTIC DISEASE. 

A. M. A. Arch. Int. M., 1952, 90: 763- 

773. 

4-28 

18 refs. Terramycin in doses of 

g over a period of 4-17 days was 

administered to 10 patients with various 

cancers. Penicillin in doses of 8-12 ml 

was administered intravenously to 3 other 

patients. 

fects that 

Both drugs 

8 patients 

had such toxic ef 

treated with terramycin 

and 2 treated with penicillin 

died. It is suggested that impaired 

renal function may slow the excretion of 

terramycin and penicillin to such an ex 

tent that blood levels toxic to the 

patients ensue. 

2695 

Berinskaia, A. N. K TERAPII OSTRYKH LEÃ•KOZOV. 

[TREATMENT OF ACUTE LEUKEMIAS.] Vrach. dÃ©lo, 

1946, 9: 609-616. To 9 patients with acute 

myi'loid leukemia a combined therapy of 20.000 

units of penicillin was administered every 

3 hours and 100 cm3 of erythrocyte transfusion 

was given daily. The peripheral blood picture 

became normalized, myeloblasts disappeared 

from the bone marrow, decrease in temperature 

and general improvement in the overall condi 

tion of the patients ensued. Two of the 

nine patients died. Four case histories are 

included. 

2696 

Bierman, H. R., Cohen, P., McClelland, J. N. 

and Shimkin, M. B. THE EFFECT OF TRANSFUSIONS 

AND ANTIBIOTICS UPON THE DURATION OF LIFE IN 

CHILDREN WITH LYMPHOGENOUS LEUCEMIA. J. Pediat., 

S. Louis, 1950, 37: 455-462. 22 refs. 

2697 

Decourt, J., Andre, R. and Guillemin, J. ANEMIE 

GRAVE,FEBRILE. 

TRAITEE PAR LA 

AVEC ASPECT DE LEUÃ‡OSE AIGUÃ‹ 

PENICILLINE,ASSOCIEE A DES 

TRANSFUSIONS SANGUINES REPETEES. GUERI SON 

APPARENTE DEPUIS QUATORZE MOIS. [GRAVE FEBRILE 

ANIMI A WITH ASPECT OF ACUTE LEUKOSIS, TREATED 

WITH PENICILLIN AND REPEATED BLOOD TRANSFUSIONS: 

APPARENT RECOVERY FOR 14 MONTHS.] Bull. Soc. 

mÃ©d. hop. Paris, 1946, 62: 622-625. Discussion 

p. 624-625. 2 refs. A~Tater report, essential 

ly the same, but including illustrations appears 

in: Presse mÃ©d., 1947, 55: 378-379. Final re 

port of this case in: BÃ¯Ã¯Tl.Soc. mÃ©d. hop. 

Paris, 1950, 66: 47-50. 

2698 Decourt, J., Andre, R., Guillemin, J. and Berthet, 

G. RECHUTE ET Ã‰VOLUTION FATALE D'UNE LEUCEMIE 

AIGUÃ‹ APRÃˆS UNE REMISSION COMPLETE DE TROIS 

ANS ET SEPT MOIS. [RELAPSE AND FATAL EVOLU 

TION OF A CASE OF ACUTE LEUKEMIA AFTER A COM 

PLETE 

Bull. 

REMISSION OF THREE YEARS AND SEVEN MONTHS.] 

soc. mÃ©d. hop. Paris, 1950, 66: 47-50. 

Discussion: p. 49-50. 7 refs. Final report of 

case treated with penicillin. 

2699 DobrovolskaÃ¯a-ZavadskaÃ¯a, N. MODE D'ADMINIS 

TRATION DE LA PENICILLINE, ET SON EFFET DANS 

UN CAS DE CANCER DISSEMINE DU SEIN. [MODE 

0F ADMINISTRATION OF PENICILLIN AND ITS 

EFFECT ON DISSEMINATED BREAST CANCER.] 

C. rend. Acad. . se., 1947, , 224: 690-692. -. 

2 refs. Abstracted in: Index analyt. cancer., 

Par., 1948, 19: No. 225. 

2700 

* 

Fradkina, , V. . E. . and Zlotnikova, , S. . V. . SLUCHAI 

OSTROGO MIELOBLASTICHESKOGO LEIKOZA, LECHENNOGO 

PENICILLINOM. [PENICILLIN TREATMENT IN ACUTE 

MYELOBLASTIC LEUKEMIA.] Klin, med., Moskva, 

1948, 26: No. 8, 82-88. Daily administration 

of 3007000 units of penicillin in conjunction 

with transfusions of erythrocytic suspension 

and liver extract given intramuscularly caused 

a decrease of leucocyte count from 1800 to 

750, followed by a gradual disappearance of 

myeloblasts. A total of 4,000.000 units of 

penicillin were administered over a period of 

three weeks. No remissions occurred in the 

next six months. At that time the final 

normalization of the blood picture was attri 

buted to a pneumonic infectionÂ« 

2701 

FuÃ , C. REMISSIONE CLÃ•NICA IN DUE CASI DI LEU 

CEMIA ACUTA CON TRATTAMENTO ASSOCIATO PENI- 

CILLINICO E TRASFUSIONALE. [CLINICAL RE 

MISSION IN TWO CASES OF ACUTE LEUKEMIA TREATED 

WITH PENICILLIN IN COMBINATION WITH BLOOD 

TRANSFUSIONS.] 

31: 607-616. 

Haematologica, Pavia, 1948, 


2702 

Hiroyoshi, S. and HyÃdÃ,S. A CASE OF MYELO- 

BLASTIC LEUKEMIA ON WHICH TREATMENT WITH 

PENICILLIN WAS TRIED. 

25: 385-387. 

Rinsyo & kenkyu, 1948, 

2703 

Klauder, J. V. and Hardy, M. K. MYCOSIS FUNGOIDES 

TREATED WITH 

Chic., 1948, 

PENICILLIN. 

57: 414-415. 

Arch. Derm. Syph., 

Discussion: p. 415. 

2704 

Marmont, A. LA PENICILLINA E L'EXSANGUINO-TRAS- 

FUSIONE NELLA TERAPIA DELLE LEUCEMIE ACUTE. 

[PENICILLIN AND EXSANGUINE-TRANSFUSION IN THE 

THERAPY OF ACUTE LEUKEMIA.) Accad. med., Tor., 

1948, 63: 565-583. 

2705 

Pierini, L.E. and Grinspan, D. RESULTADOS OB 

TENIDOS EN EL TRATAMIENTO DE LA SARCOMATOSIS 

DE KAPOSI POR LA PENICILINA: COMMUNICACIÃ“N 

PREVIA. [RESULTS OF PENICILLIN TREATMENT OF 

KAPOSI SARCOMA; PRELIMINARY REPORT.] 

argent, derm, sif., 1948, 32: 3-14. 

Rev. 

2706 

Thiersch, J. B. THE FAILURE OF PENICILLIN AND 

DIRECT BLOOD TRANSFUSION IN THE TREATMENT OF 

ACUTE LEUCHAEMIA. 

2: 743-744. 

Med. J. Australia, 1946, 

2707 

Â»Viarengo, G. and Debenedetti, L. TERAPIA DELLA 

LEUCEMIA ACUTA CON 

SALASSO-TRASFUSIONE 

UNA PARTICOLARE 

E PENICILLINA. 

TECNICA DI 

[THERAPY 

OF ACUTE LEUKEMIA WITH THE SALASSO TECHNIQUE 

OF BLOOD TRANSFUSION AND PENICILLIN.] Minerva 

med., Tor., 1949, 40: pt. 2, 886-893. 

See 

555 1086 1874 

PENICILLIN 

G 

2708 

Camus, G. ACTION DE LA PENICILLINE G SUR LA 

CROISSANCE DE TISSUS NORMAUX ET TUMORAUX 

CULTIVES IN VITRO. [EFFECT OF PENICILLIN 

G ON GROWTH OF NORMAL AND TUMOR TISSUE CUL 

TURED IN VITRO.] C. rend. Acad. sc., 1954, 

238: 1058-1060. The growth of ScorsonÃ¨re 

Crown gall tissue is unaffected by penicillin 

G in concentrations of 0.000002-800,slightly 

inhibited by higher concentrations. The pre 

sence or the absence of indoleacetic acid 

has no effect on this action.



155 

PENICILLIN 

NOTATUM 

2709 

Cantero, A., Azevedo, S. de Barros and Leao, 

A. E. de NECROTIZING AND ANTINEOPLASTIC 

EFFECTS OF NEW CRUDE FUNGI EXTRACTS IN 

SARCOMA BEARING MICE (S. 37). EXPERI 

MENTAL AND CLINICAL OBSERVATIONS ON ITS USE 

IN NEOPLASTIC DISEASE IN MAN. Acta UniÃ³ 

internat, cancr., Brux., 1951, 7: 448-455. 

7 reÃs. Protuguesc version in:~Rev. brasil, 

cancerol., 1952, 5: 43-48. Abstracted in: 

Excerpta ned., Sect. 16, 1954, No. 1179. 

2710 

Ciferri, R. AZIONE ANTINEOPLASICA DI ESTRATTI 

E LIQUIDI CULTURALI FUNGINI. [THE ANTINEO 

PLASTIC ACTION OF EXTRACTS AND FILTRATES 

FUNGUS CULTURES.] Farmaco, Pavia, 1947, 

OF 

2: 


1948, 1^:No. 6024. A short review. 

2711 

Meyer, J. R. DESENVOLVIMENTO DE PRINCIPIOS ANTI- 

NEOPLÃ‚SICOS EM LÃ•QUIDOS DE CULTURA DE P. NOTATUM, 

SEM ENXOFRE. [DEVELOPMENT OF ANTINEOPLASTIC 

PRINCIPLES IN SULFUR-FREE CULTURE FLUIDS OF PENI 

CILLIUM NOTATUM.] Arq. Inst. biol., S. Paulo, 

1950-51, 20: 177-181. "As the antineoplastic 

activity Ã–T culture media on which Aspergillus 

fumigatus had grown was due to gliotoxin, it 

was supposed that the same substance was res 

ponsible for the antineoplastic action of the 

Czapek-Dox medium on which PÃ©nicillium notatimi 

was cultivated. As gliotoxin has a molecule 

in which sulfur exists, P. notatum was culti 

vated on nutritive solutions without sulfates 

in order to avoid its formation. The fact that 

cultures 

show the 

on nutrituve solutions without sulfates 

same anti-neoplastic activity is taken 

as an evidence that in this case gliotoxin is 

not the substance responsible 

neoplastic activity." 

for the anti 

See 

1071 1769 

PENICILLIUM 

SPEMOLOSUM 

2712 

Hulshoff Pol, D. J. BEHANDELING VAN ENT-KANKER 

BIJ MUIZEN EN DE HELLICHT DAARUIT TE TREKKEN 

CONCLUSIES VOOR DE MENS. [TREATMENT OF GRAFTED 

CANCERS IN MICE AND POSSIBLE CONCLUSIONS FOR 

HUMAN BEINGS.] Geneesk. gids, 1949, 27: 512- 

515. Mouldy bread belongs to the normal diet 

of these animals. Dried preparations of cul 

tures of PÃ©nicillium spinulosum Thorn, on 

bread were given to the diet of 12 mice with 

grafted cancer tumours which were the size of 

a pea. In some of the mice the tumours con 

tinued growing for some time and then gradually 

dried up. 

PENIT ALINE 

2713 

Robert, A. F. and Havas, L. J. ACTION DE L'ABIO- 

TIQUE "PENITALINE" SUR LES TUMEURS COLCHICI- 

NIQUES ET SUR LA CROISSANCE SOMATIQUE DU BLÃ‰" 

[THE ACTION OF THE ANTIBIOTIC "PENITALINE" ON 

TUMORS PRODUCED BY COLCHICINE AND ON THE GROWTH 

OF WHEAT.] Acta UniÃ³ internat, cancr., Louvain 

1951, 7: 515-517. 4 reÃs. 

PENTAMroiNE 

see BENZAMIDINE, 

DIOXY) DI- 

PEROXIDE, 

See 

HYDROGEN 

94 295 1839 

4, 4'-(PENTAMETHYLENE- 

PEROXIDES, 

See 

1760 

ORGANIC 

PESTICIDES 

2714 

Belkin, M. and Fitzgerald, B. TUMOR-DAMAGING 

CAPACITY OF PLANT MATERIALS. III. PLANTS 

USED AS PESTICIDES. J. Nat. Cancer Inst., 

1953, 13: 889-893. 7 refs. 

PHARMACOLOGY AND PHYSIOLOGY 

For the pharmacological and physiological 

effects of a specific agent, see under the 

agent. 

2714a 

Bastrup-Madsen, P. ACTION OF SOME ANTINEO- 

PLASTIC CHEMOTHERAPEUTICAL AGENTS ON CELL 

DIVISION. 

36: 452-460. 

ActaRadiol., 

3 reÃs. Abstracted 

stockh. 

in: 

1951 

' 

CBeM. Abstr. 1952, 46: No. 4113c. "The 

â€¢¿orphological effecfbf colchicine, Â»rsenicals, 

urethan, and nitrogen Bustards 

on dividing cells is described." 

2714* 

Bran, A. ZUM VERHALTEN DER MITOCHONDRIEN BEI 

EINWIRKUNG VERSCHIEDENER PHARMAKA. UNTER 

SUCHUNGEN MIT DEM PHASENKONTRASTMIKROSKOP AN 

GEWEBEKULTUREN. [EFFECT OF VARIOUS DRUGS ON 

MITOCHONDRIA; TISSUE CULTURE STUDIES BY MEANS 

OF PHASE CONTRAST MICROSCOPY.] Acta anat 

Basel, 1951, 13: 385-402. Bibliography: 

P. 401-402. English summary, study includes 

colchicine, nicotine, arsenic, trypaflavine 

and nitrogen mustard and a review of the 

literature. 

2714e 

Kanamori, H. ABOUT CHEMOTHERAPY OF YOSHIDA 

SARCOMA, WITH SPECIAL REFERENCE TO ITS 

RELATION TO WANDERING VELOCITY OF LEUKOCYTES 

Gann, Tokyo, 1954, 45: 481-484. In Japanese' 

2714d 

Tanakadate, Y. and Sarukashi, Y. THE INFLUENCE 

OF ANTICARCINOGENIC AGENTS ON PHAGOCYTOSIS OF 

LEUKEMIC 

237-243. 

CELLS. Nagoya J. M. 


Sc., 1952 15" 

in: Leukemia" 

Abstr., 1953, 1: No. 403. 

PHENANTHRENE 

DERIVATIVES 

2715 

Field, J. B.. Kloetzel, M. C., Costa, F. and 

Boryczka, A. INHIBITION OF THE MOUSE CROCKER 

SARCOMA 180 WITH PHENANTHRENE DERIVATIVES. 

Acta UniÃ³ internat, cancr., Louvain, 1955 

11: 139-142. 8 refs. "Five of 55 phenan- 

Ã¯Erene derivatives selected at random in a 

screening project were found to have a mild 

but consistent inhibitory effect on the growth 

Â»f the mouse Sarcoma 180. The resulting tumors 

measured 1/2 to 3/4 the size of the control 

tumors. The active phenanthrenes were se 

condary or tertiary amines, four of them con 

tained a substituent in either the 9 or 10 

position and one 

in position 3." 

contained a substituent only 

See 

254 

PHENANTHRIDIUM 

COMPOUNDS 

2716 

Â»Dickinson, L., Chantrill, B. H., Inkley, G. W. 

and Thompson, M. J. THE ANTIVIRAL ACTION OF 

PHENANTHRIDINIUM COMPOUNDS. Brit. J. Pharm.. 

1953, 8: 139-142. Abstracted in: Chem. Abstr 

1953, Ã•7: 8829b.



156 

PHENAZINE 

See 

121 

PHENERGAN 

see PHENOTHIAZINE, 

PHENOL, 

10-(2-DI-METHYLAMINOPROPYL- 

DINITRO- 

2717 

Finkeltshtein, E. A. AKTIVNOE VMESHATEL'STVO 

V OBIIEN VESHCHESTV ORGANIZMA V BOR'BE SO 

ZLOKACHESTVENNY1Ã•IOPUKHOLIAMI. [ACTIVE INTER 

FERENCE WITH METABOLIC PROCESSES IN THE COM 

BATING 

biol., 

OF MALIGNANT TUMOURS.] Zh. 

Moskva, 1952, 13: 249-269. 

obshch. 

Approx. 

50 reÃs. Abstracted TE: Excerpta med., Sect. 

16, 1954, 2: No. 1175. Dinitrophenol and 

iodoacetic acid inhibited the growth of trans 

planted and experimentally induced tumors. 

PHENOL, 2, 4-DINITRO- 

2718 

Bodine, J. H. THE COMBÃ•NED ACTION OF 2,4- 

DINITROPHENOL AND ETHYL CARBAMATE (URETHANE) 

ON THE OXYGEN UPTAKE OF EMBRYONIC CELLS. 

Physiol. Zool., 1950, 23: 63-67. 13 refs. 

2719 

Windisch, F. and Heumann, W. HEMMUNG DES KREBS 

WACHSTUMS DURCH 2,4-DINITROPHENOL (DNP). 

BEDEUTUNG VON DNP ALS 

TION OF CANCER GROWTH 

ZYTOSTATIKUM. [INHIBI 

BY 2,4-DINITROPHENOL 

(DNP). IMPORTANCE OF DNP AS CYTOSTATIC AGENT.] 

Experiments 


on induced 

1954, 

tumors* 

41: 

in 

481. 

mice 

12 

and 

refs. 

rats 

showed repression or cessation of growth after 

DNP administration. It was possible to enhance 

this action by sperm hyaluronidase. 

2720 

Windisch, F., Heumann, W., Linser, K. and 

Langer, H. REGRESSION MALIGNER TUMOREN DURCH 

INJIZIERUNG UND PER ORALE VERABREICHUNG VON 

ZYTOSTATISCHEN ANTIMETABOLITEN. [REGRESSION 

OF MALIGNANT TUMORS THROUGH THE ADMINISTRATION 

OF CYTOSTATIC ANTIMETABOLITES BY INJECTION OR 

BY MOUTH.] Naturwissenschaften, 

394-395. 7 refs. 

1955, 42: 

2721 

Peters, K., Krais, W. and GÃ¤rtner, H. DAS 

VERHALTEN VON MAUSEASCITESTUMOREN UNTER DER 

ALLEINIGEN ODER KOMBINIERTEN WIRKUNG VON 

MEGAPHEN UND RADIUM. 

ASCITES TUMORS UNDER 

[BEHAVIOUR OF MOUSE 

TREATMENT WITH "MEGAPHEN" 

AND COMBINED TREATMENT WITH "MEGAPHEN" AND 

RADIUM.] 2 refs. In Naturwissenschaften, combination with radium 1955, "Se'gaphen" 

42: 50. 

2-CHLORO-10-(3-DIMETHYLAMINO- 

PHENOTHIAZINE, 

PROPYL)- 

was administered in doses of 0.25 mg per 20 g 

of body weight to mice bearing ascites tumor. 

The treatment had a stronger effect in reducing 

rate of mitosis and inducing cytolysis of car 

cinoma cells than treatment with either agent 

given alone. 

PHENOTHIAZINE, 10-(2-DI-METHY"LAMINOPROPYL- 

See 

742 

PHENOTHIAZINE DERIVATIVES 

'2722 

Chary, R. ACTION D'UN DERIVÃ‰DE LA PHENOTHIAZINE 

SUR LA SURVIE 'IN VITRO' DES LEUCOCYTESHUMAINS. 

[EFFECTS OF A PHENOTHIAZINEDERIVATIVE ON SUR 

VIVAL OF HUMANLEUCOCYTESIN VITRO.] Sang, 

Par., 1951, 22: 307-314. 11 refs. "N-dimethyl 

amino 2-methyT-l phenothiazine-(D.M.P.)" in 

concentration of 1:10,000 retards protoplasmic, 

nuclear and phagocytic changes in leucocytes. 

PHENOXAZINES 

2723 

Lewis, M. R., Goland, P. P. and Sloviter, H. A. 

THE ACTION OF OXAZINE 


DYES ON TUMORS IN MICE. 

736-740. 8 refs. Ab 

stracted in: Chem. Ã‚bstr., 1950, 44: 2637d. 

PHENTIAZID, DIMETHYL -AMTNO-ACETYL- 

2725 

Karolyhazy, G.. Havas, I., JancsÃ³,



157 

PHOSPHATE, ORTHO-TRICRESYL (Continued) 

2731 Cruz Coke, E., Plaza de los Reyes, II. and Scarella, 

A. COMPORTAMIENTO DE LOS Ã•CIDOS RIBO Y DESOXI- 

RIBONUCLEICOS 

EL HÃ•GADO DE 

EN EL SARCOMA 

RATAS TRATADAS 

TRANSPLANTABLE Y EN 

CON ORTOTRICRESIL- 

FOSFATO. [BEHAVIOR OF RIBO- AND DESOXYRIBONU- 

CLEIC ACIDS IN TRANSPLANTABLE SARCOMAS AND IN 

LIVER OF RATS TREATED WITH ORTHOTRICRESYL 

PHOSPHATE.] Bol. Soc. Biol. Santiago, 1950, 

7: 71-76. Abstracted in: Excerpta med., Sect. 

5, 1951, 4: No. 3488. "Daily injections of 

0.24 g of~tricresyl phosphate lowered the DRN 

content of normal rat livers and of the livers 

of tumour-bearing animals in which the treat 

ment halted the tumour development or caused 

regression, but was without effect if the 

tumours grew further; nor did it lower the 

content of DRN in the tumour tissue." -Excerpta 

med. 

PHOSPHOMOLYBDIC 

See 

2748 2749 

PHOSPHORAMIDE, 

See 

2734 2736 

PHOSPHORAMIDE, 

ACID 

DIETHYLENE- 

N, N1, N"-TREITHYLENE- 

2732 

Allison. J. B., Wannemacher, R. W., Jr., Hilf, 

R., Migliarese, 

DIETARY PROTEIN 

J. F. and Crossley, U. L. 

AND TUMOR-HOST RELATIONSHIP 

IN THE RAT. J. Nutrit., 1954, 

10 refs. Abstracted in: Chem. 

54: 593-600. 

Ab~str., 1955, 

49: 3336b. "N,N' ,N" -triethylenephosphoramTde 

reduced the development of both tumor 

and carcass; food utilization by the carcass 

was also reduced in the presence of this 

drug. Supplementing 12% of casein with methionine, 

or feeding high protein diets, 

favored the development of the carcass in 

the presence of TEPA, resulting in a more 

favorable condition for long survival 

and regression of the tumorâ€ž" 

time 

2733 

Bernard, J. and Deltour, G. LES NOUVEAUX TRAITE 

MENTS DES LEUCOSES; T.E.P.A., G.T.41 (MYLERAN), 

6-MERCAPTOPURINE, X3 -MERCAPTOETHYLAMINE, DOSES 

TRÃˆS FORTES DE CORTISONE. [THE NEW TREATMENTS 

OF LEUKEMIA: TEPA. G.T.41 (MYLERAN). 6-MERCAPTO- 

PURINE, -MERCAPTOETHYLAMINE, VERY LARGE DOSE 0F 

CORTISONE.] Sem. hop. Paris, 1953, 29: 3430- 


Sect. 16, 1954, 2: No. 3168. 

2734 

Buckley, S. M., Stock, C. C., Parker, R. P., 

Crossley, M. L., Kuh, E., Seeger, D. R., 

Boryczka, A. T., Costa, F. M. and Bailey, V. M. 

INHIBITION STUDIES OF SOME PHOSPHORAMIDES 

AGAINST SARCOMA 180. Proc. Soc. Exp. Biol., 


in: Chem. AbsÃ¯F., 1952, 46: 1640h. 

2735 

Farber, S., Appleton, R., Downing, V., Heald, F. , 

King, J. and Toch, R. CLINICAL STUDIES ON THE 

CARCINOLYTIC ACTION OF TRIETHYLENEPHOSPHORAMIDE. 

Cancer, Phila., 1953, 6: 135-141. "Of 69 pa 

tients with advanced or disseminated cancer, 

54 showed no objective evidence of improvement 

following the administration of TEPA as part 

of their total care. Evidences of important 

degrees of improvement were observed in patients 

with Hodgkin's disease, neuroblastoma, undifferentiated 

carcinoma, and malignant melanoma. 

Improvement probably attributable to the TEPA 

was observed in patients with Wilms1 tumor, 

adenocarcinoma of the pancreas, angiosarcoma, 

and hemangioendotheliorna. The small number 

of patients treated makes impossible a general 

statement concerning the exact value or sphere 

of activity of TEPA as a carcinolytic agent. 

Its spectrum appears to be broader than that 

of nitrogen mustard or triethylenemelamine. 

The toxic changes produced by TEPA are simi 

lar to those produced by triethylenemelamine." 

2736 

Sykes, M. P., Karnofsky, D. A., Philips, F. S. 

and Burchenal, J. H. CLINICAL STUDIES ON 

TRIETHYLENEPHOSPHORAMIDE AND DIETHYLENEPHOS- 

PHORAMIDE COMPOUNDS WITH NITROGEN-MUSTARD- 

LIKE 

148. 

ACTIVITY. Cancer, Phila., 1953, 6: 142- 

"Nine patients were treated with~DEPA 

See 

320 

3367 

and 28 with TEPA. Evidences of therapeutic 

activity were seen in Hodgkin's disease, 

lymphosarcoma, chronic lymphatic leukemia, 

mycosis fungoides, and in an unusual case of 

metastatic leptomeningeal sarcoma. TEPA did 

not appear to produce any benefit in patients 

who would not be expected to respond to HN2 

or TEM." 

1206 

3382 

2212 

3384 

2649 

3461 

PHOSPHORAMIDE, TRIETHYLENE THIO- 

3363 

2737 

Bateman, J. C. 

FAR-ADVANCED 

and McCabe, 

CANCER WITH 

M. PALLIATION OF 

TRIETHYLENE THIO- 

PHOSPHORAMIDE. 


Acta UniÃ³ internat, cancr., 

11: 111-114. 5 reÃs. 

"Favorable resulÃ¯s of therapy included in 

creased sense of well-being, alleviation of 

pain, shrinkage of visible tumor masses, con 

trol of ascites and hydrothorax, decreased 

dyspnea, cough and dysphagia. 

2738 

Bateman, J, C., Moulton, B. and Larsen, N. J. 

CONTROL OF NEOPLASTIC EFFUSION BY PHOSPHORA 

MIDE CHEMOTHERAPY. 

1955, 95: 713-719. 

A.M.A. Arch. 

7 refs. 

Int. M., 

2739 

Shay, H. and Sun, D. C. H. CLINICAL STUDIES 

OF TRIETHYLENETHIOPHOSPHORAMIDE IN THE TREAT 

MENT OF INOPERABLE 

1955, 8: 498-511. 


22 refs. 

Cancer, Phila., 

Results ob 

tained from use of thio-TEPA in 47 patients. 

2740 

Shay, H., Gruenstein, M. and Atwater, J. 

EFFECT OF TRIETHYLENE THIOPHOSPHORAMIDE 

6-MERCAPTOPURINE IN CHRONIC MYELOGENOUS 

AND 

AND 

IN AN ACUTE LEUKEMIA IN RATS. Acta UniÃ³ 

internat, cancr., Louvain, 1955, 11: 179- 

185. 9 refs. "Thio-TEPA has prolonged life 

of rats with the chronic leukemia from an 

average survival time of 9 days...to as long 

as 53 weeks...Blood count and bone marrow 

could return to normal and on occasion the 

animal would remain 

mission. ..Treatment 

in hematological re 

with 6-mercaptopurine 

3.5 

the 

mg/kg 

lives 

by stomach catheter daily prolongs 

of rats with the chloro-leukemia, 

but 

ent 

the remainder of effects is quite differ 

in pattern from that produced by Thio- 

TEPA. 

failed 

In the acute leukemia this compound 

to increase survival time." 

2741 

Shay, H., Gruenstein, M. and Harris, C. THE 

EFFECT OF TRIETHYLENE THIOPHOSPHORAMIDE 

(THIO-TEPA) IN THE TREATMENT OF CHRONIC 

MYELOCYTIC CHLOROLEUKEMIA IN THE RAT. 

J. Nat. Cancer Inst., 1954, 15: 463-481. 

4 pi. 9 refs.



158 

PHOSPHORAMIDE, TRIETHYLENE TmO- (Continued) 

2742 

Shay, H., Zarafonetis, C., Smith, N., Woldow, 

I. and Sun, D. C. H. TREATMENT OF LEUKEMIA 

WITH TRIETHYLENE THIOPHOSPHORAMIDE (THIO- 

TEPA); PRELIMINARY RESULTS IN EXPERIMENTAL 

AND CLINICAL LEUKEMIA. A. M. A. Arch. Int 

M., 1953, 92: 628-645. pi. 18 refs. 

AbstractedTn: Leukemia Abstr., 1954 2: 

No. 492. 

2743 

Smith, N. J., Rosello, S. and Shay, H. THE 

EFFECT OF TRIETHYLENE THIOPHOSPHORAMIDE IN 

THE TREATMENT OF LEUKEMIA AND CERTAIN LYM- 

PHOMAS IN 

S. Louis, 

INFANTS AND CHILDREN. J. Pediat., 

1955, 46: 493-505. 2 refs. 

2744 

Zarafonetis, C. J. D., Shay, H. and Sun, D. C. H. 

TRIETHYLENETHIOPHOSPHORAMIDE IN THE TREATMENT 

OF CHRONIC LEUKEMIA. 

512-522. 3 refs. 

Cancer Phila., 1955, 8: 

See 

320 3454 

PHOSPHORAMDES 

see also ETHYLENIMINES 

2745 

Crossley, M. L., Allison, J. B., Parker, R. P., 

Kuh, E. and Seeger, D. R. CHEMOTHERAPY OF 

TUMORS IN RATS. III. CHEMOTHERAPY OF TUMORS 

IN RATS WITH CERTAIN ETHYLENEPHOSPHORAMIDES. 


447. 14 refs. Abstracted in: Chem.Tbstr., 

1953, 47^: 11524h. 

2746 

Eichorn, P. A., Huffman, K. V., Oleson, J. J., 

Halliday, S. L. and Williams, J. H. A COM 

PARISON OF IN VIVO AND IN VITRO TESTS FOR 

ANTINEOPLASTIC ACTIVITY OF EIGHT COMPOUNDS. 


22 refs. Discussion: p. 1182. 

See 

2032 2738 

PHOSPHORIC ACID, DIETHYL p-NITROPHENYL 

ESTER 

2747 

Mendel, B., Myers, D. K., Uyldert, I. E., Ruys, 

A. C. and Bruyn, W. M. de ALI-ESTERASE INHI 

BITORS ANDGROWTH. Brit. J. Pharm., 1953. 

8: 217-224. 

PHOSPHOTUNGSTIC 

ACID 

2748 

Mukherjee, H. N. ACTION OF PREPARATIONS OF 

PHOSPHOTUNGSTIC AND PHOSPHOMOLYBDIC ACIDS 

ON CANCER. J. Ind. M. Ass., 

289-292. 2 pi. 4 refs. 

1952, 21: 

2749 

Mukherjee, H. N. FURTHER OBSERVATIONS ON THE 

ACTION OF PREPARATIONS OF PHOSPHOTUNGSTIC 

AND PHOSPHOMOLYBDIC ACIDS 

Indian M. Ass., 1954, 23: 

UPON CANCER. 

328-330. 

J. 

PHOTODYN 

see HEMATOPORPHYRIN 

PICOLINIUM COMPOUNDS 

2750 

Peters, V. B. SOME ASPECTS OF A JOINT INSTITU 




AND WITH SYNTHETIC ORGANIC COMPOUNDS. III. 

METHOD USED IN SCREENING COMPOUNDS FOR 

POTENCY. In: APPROACHES TO TUMOR CHEMOTHERA 

PY. Wash., Am. Ass. Advance. Sc., 1947, p. 

244-246. 1 rÃ©f. 

PLACENTA 

EXTRACT 

2751 

Bariatti, R. RICERCHE SPERIMENTALI SULL'IN 

FLUENZA DELLA PLACENTA NELLO SVILUPPO DI 

TUMORI. [EXPERIMENTAL STUDIES ON THE EFFECT 

OF THE PLACENTA ON THE DEVELOPMENT OF TUMORS.] 

Neoplasie, Tor., 1950, 4: 365-378. 11 refs. 

Placenta extract in small doses injected into 

60 rats with Walker sarcoma caused inhibition 

of the developing tumors, but had no effect 

on the already developed tumors. 

2752 

Cramer, H. and Eschbach. W. WACHSTUMSHEMMUNG 

DES WALKER-CARCINOMS BEI RATTEN DURCH PLACENTA- 

EXTRAKT. [INHIBITION OF GROWTH OF WALKER 

CARCINOMA IN RATS BY PLACENTAL EXTRACT.] 

Med. Klin., Beri., 1955, 50: 161-162. Placental 

extract(Placentormon) caused growth inhi 

bition in white rats with transplanted Walker 

carcinoma, particularly when treatment pre 

ceded transplantation. 

2753 

Dubrovsky, R. CONTRIBUCIÃ“N AL ESTUDIO DE LA 

PLACENTA EN SU RELACIÃ“N CON LA BLASTOMATOSIS. 

[CONTRIBUTION TO THE STUDY OF THE RELATION 

SHIP OF THE PLACENTA TO BLASTOMATOSIS.] 

Obst. gin. lat. amer., 1953, 1_1: 204-208. 

Total extract of placenta in various con 

centrations and doses had an inhibiting effect 

on transplantable sarcoma in rats. 

2754 

Hummel, K. P., Uttle, C. C. and Eddy H S 

STUDIES ON THE MOUSE MAMMARY TUMOR AGENT' 

THE NEUTRALIZATION OF THE AGENT BY PLACENTA. 


2755 

Kludas, M. and Stcss , B. TIEREXPERIMENTELLE 

UNTERSUCHUNGEN ÃœBERDIE WIRKSAMKEIT EINES 

EXTRAKTES AUS HUMANPLACENTA ALS GRUNDLAGE 

FÃœRSEINE THERAPEUTISCHE ANWENDUNG. 

[THERAPEUTIC SIGNIFICANCE OF THE RESULTS OF 

ANIMAL EXPERIMENTS ON THE EFFICACY OF AN 

EXTRACT OF THE HUMAN PLACENTA.] Aerztl. 

Wschr., 1953, 8: 841-843. 

2756 

Krtlger, H. H. KLINISCHE ERFAHRUNGEN MIT EINEM 

INTRAMUSKULÃ„RINJIZIERBAREN EXTRAKT AUS 

HUMANPLACENTABEI DER BEHANDLUNG INOPERABLER 

TUMOREN. [CLINICAL RESULTS WITH INTRA-MUSCU- 

LARLY INJECTED EXTRACT FROM THE HUMAN PLACENTA 

IN THE TREATMENT OF INOPERABLE TUMORS.] 

Aerztl. Wschr., 1953, 35: 843-845. 

2757 

Martinetto, G. PLACENTA E TUMORI SPERIMENTALI. 

[PLACENTA AND EXPERIMENTAL TUMORS.] Neoplasie, 

Tor., 1948, 3: 213-224. 27 refs. Hydroglyceric 

placenta extract in doses of 50 eg in 

jected into 24 albino rats with Ehrlich adenocarcinoma 

increased the growth of the tumor, 

and had no effects upon survival time or the 

loss of body weight. 

2758 

Profitlich. H.. Resch. E. and Wulf, W. ÃœBER 

DIE WIRKUNG VON PLACENTAINHALTSSTOFFEN AUF 

DEN ASCITESTUMOR DER MAUS. [EFFECT OF PLA 

CENTAL EXTRACTS ON MOUSE ASCITES TUMOR.] 

Zschr. Krebsforsch., 1955, 60: 390-398. 

See 

657 1926



159 

PLANT 

EXTRACTS 

For an extract of a specific plant see under name of the 

plant or the specific name of the extract 

2759 Belkin, U. and Fitzgerald, D. B. TUMOR-DAMAGING 

CAPACITY 

PLANTS. 

OF PLANT MATERIALS. V. MISCELLANEOUS 

J. Nat. Cancer Inst., 1953, 14: 607- 

625. 16 reÃs, "About 150 plant materials, 

representing 55 botanical families, were exa 

mined for tumour-necrotizing effect, following 

a single injection, on sarcoma 37 in CAF1 

mice. Twenty-one plants, or 14% of those 

tested, showed some 

tions employed." 

activity under the condi 

2760 

Grasseli, G. NOTA PREVENTIVA SULLA QUIESCENZA 

ORGANICA DEI TESSUTI FORMATIVI VEGETALI COME 

ELEMENTO INDIZIARIO NELLA RICERCA DI CHIMISMI 

ANTICARIOCINETICI DA SPERIMENTARE SUI TUMORI 

ANIMALI. [THE ORGANIC INHIBITION OF PLANT 

TISSUES; ITS IMPORTANCE IN RESEARCH ON ANTI- 

MITOTIC SUBSTANCES IN EXPERIMENTAL TUMOURS. 

A PRELIMINARY NOTE.] Tumori, Milano, 1949, 

23: 250-258. 21 reÃs. AbstractedA 

in: 


See 

1689 

PLASMODIUM 

2761 

Nadel, E. M., Greenberg, J. and Coatney, G- R. 

THE EFFECT OF MALARIA (PLASMODIUM BERGHEI) 

ON LEUKEMIA L 1210 IN MICE. J. Infect. Dis., 


ExcerpTa med., Sect. 5, 1955, 8: No. 1074. 

2762 

Trager, W. and McGhee, R. B. INHIBITION OF 

CHICKEN TUMORI BY PLASMAFROMCHICKENS IN 

FECTED WITH AN AVIAN MALARIAPARASITE. 

Proc. Soc. 

349-352. 

Exp. Biol., 

7 refs. 

N. Y., 1953, 83: 

PLASMOL 

See 

3115 

PLENOSOL 

see MISTLETOE 

PODOPHYLLIN 

2763 Zaunick, R. PODOPHYLLINHARZ IN NEUER MEDI 

ZINISCHER UND BIOLOGISCHER ANWENDUNG. [PODO 

PHYLLIN SAP IN RECENT MEDICAL AND BIOLOGICAL 

APPLICATION.] Pharmazie, 1949, 4: 35-36. 


2764 Cdi'ninaii,I. and Cornman, M. E. THE ACTION OF 

PODOPHYLLIN AND ITS FRACTIONS 

Ann. N. York Acad. So., 1951, 

ON MARINE EGGS. 

51: 1443-1481. 


podophyllotoxin, 

Colchicine, podophyllin, 

picropodophyllin, podophyllic 

acid, depodophyllotoxinized pvdophyllin 

and two fractions of depodophyllotoxinized 

crude podophyllotoxin were used in this 

study. 

2?King, L. S. EFFECTS OF PODOPHYLLIN ON MOUSE 

SKIN. I. HISTOLOGIC SEQUENCE AFTER A SINGLE 

DOSE. J. Nat. Cancer Inst., 1948, 8: 215- 

225. 3 pi. 9 refs. Abstracted in: Excerpta 

â€¢¿ed., Sect. 5, 1949, 2: No. 2286; Chem. 

Abstr., 1948, 42: 744Ze. 

2766 

King, L. S. EFFECTS OF PODOPHYLLIN ON MOUSE 

SKIN. III. A STUDY OF EPIDERMAL FIBRILS. 



2767 

King, L. S. and Cauldwell, E. W. EFFECTS OF 

PODOPHYLLIN ON MOUSE SKIN. II. CONSIDERA 

TION OF SOME FUNCTIONAL 

Cancer Inst., 1949, 10: 

ASPECTS. 

131-146. 

J. Nat. 

3 pi. 

15 refs. 

2768 

Â»Lovisetto, P. and Turco, G. L. COMUNICAZIONE 

PRELIMINARE SULL'AZIONE LEUCOPENIZZANTE 

DELLA PODOFILLINA. 

LEUCOPENIA-PRODUCING 

[PRELIMINARY NOTE ON THE 

ACTION OF PODOPHYLLIN.] 

Accad. Med. Tor., 1950, 112: 75-79. Abstrac 


No. 3182. 

2769 

Lovisetto, P., Segre, G. and Turco, G. L. 

SULL'AZIONE LEUCOPENIZZANTE DELLA PODO 

FILLINA. [LEUKOPENIC EFFECT OF PODO 

PHYLLIN.] Arch, internat, pharm. 

Par., 1950, 84: 68-80. 13 refs. 

dyn. 

2770 Lovisetto, P., Segre, G. and Turco, G. SULL'AZIONE 

LEUCOPENIZZANTE DELLA PODOFILLINA. ATTIVITÃ€ DI 

DIVERSE 

FECT OF 

FRAZIONI. II. [ON THE 

PODOPHYLLIN. EFFECT OF 

LEUKOPENIC EF 

VARIOUS FRAC- 

TIONS. II.] Arch. internat, pharm. dyn. Gand., 

1952, 89: 269-278. 16 refs. 

2771 

SÃ¡nchez Caballero, H. J. and Ergueta Collao, J. 

ACTION OF PODOPHYLLIN ON THE NUMBER OF BLOOD 

LEUKOCYTES. Experientia, Basel, 1949, 5: 250- 

251. 8 refs. Intraperitoneal injections of 

podophyllin caused a 40% decrease in the leu 

cocyte count of normal white rats. 

2772 

SÃ¡nchez Caballero, [H.] J. and ErgueÃ‡a Collao, J. 

ACCIÃ“N DEL PODOFILINO SOBRE LOS GLÃ“BULOS 

BLANCOS. [THE EFFECT OF PODOPHYLLIN ON 

LEUCOCYTES.] Rev. espan., fisiol., 1949, 

5: 

2773~ 

141-147. 15 refs. English summary. 

Sentein, P. ACTION ANTIMITOTIQUE DE LA PODO- 

PHYLLINE PENDANT LA SEGMENTATION DE L'OEUF 

DE TRITON. [ANTIMITOTIC ACTION OF PODO 

PHYLLIN DURING SEGMENTATION OF THE TRITON 

EGG.] C. rend. Ass. anat., 1953, 40: 301- 

308. 10 refs. 

2774 

Sentein, P. LA PODOPHYLLINE, INHIBITEUR DU 

CLIVAGE ET DE LA POLARITÃ‰ FUSORIALE DANS 

L'OEUF DE TRITON. [PODOPHYLLIN, INHIBITOR 

OF SPINDLE CLEAVAGE AND POLARITY IN THE 

TRITON EGG.] 

145: 667-668. 

C. rend. 

4 refs. 

Soc. biol., 1951, 

2775 

Veronesi, U. AZIONE DELLA PODOFILLINA E DELLA 

PODOFILLOTOSSINA SULLA CRASI EMATICA NEL 

RATTO. [EFFECT OF PODOPHYLLIN AND PODOPHYLLO 

TOXIN ON THE BLOOD COMPOSITION OF THE RAT. 


See 

775EFFECT 

776 ON TUMOR 796GROWTH799 

2776 

Belkin, M. EFFECT OF PODOPHYLLIN ON TRANSPLANTED 

MOUSE 

18-25. 

TUMORS. 

7 refs. 

J. 

Podophyllin 

Pharm. Exp. 

in 

Ther., 

sesame 

1948. 

oil ~~ 

93: 

given subcutaneously in doses of 20 mg per kg 

to mice bearing 15-day-old implants of sarcoma 

180 or mammary adenocarcinoma caused reduction 

in size of the sarcoma to 1X7 and that of 

the carcinoma to 2/3 of the volumes of their 

respective controls.



160 

PODOPHYLLIN 

(Continued) 



2777 

Bunge. Râ€žG. CYTODYNAMIC PROPERTIES OF URINARY 

NEOPLASMS. IV. CULTIVATION IN VITRO OF TRAN 

SITIONAL CELL CARCINOMA OF THE FEMALE URETHRA. 

J. Urol., Bait., 1954, 71: 608-610. 

2778 

Kelly, M. G. and Hartwell, J. L. THE BIOLO 

GICAL EFFECTS AND THE CHEMICAL COMPOSITION 

OF PODOPHYLLIN. A REVIEW. 

Inst., 1954, 1_4: 967-1010. 


377 refs. A 

review. See: p. 967-986 for biological 

effects, clinical uses and experimental 

clinical trials. 

2779 



WITH PODOPHYLLIN, PODOPHYLLOTOXIN, ALPHA- 

PELTATIN, BETA-PELTATIN, AND QUERCETIN. 



2780 

Loran, M. R. and Guth, E. P. PRELIMINARY REPORT 

OF LYSIS OF MOUSE SARCOMA 37 BY A COMPONENT 

ISOLATED FROM RESIN OF PODOPHYLLUM. J. Am. 

Pharm. Ass., Se. Ed., 1951, 40: 254. Abstracted 

in: Excerpta med., Sect. 2, IÃ•Ã•52,5: No. 2388. 

2781 

llakino, S. and Tanaka, T. THE CYTOLOGICAL EF 

FECT OF CHEMICALS ON ASCITES SARCOMAS. I. 

PARTIAL DAMAGE IN TUMOR CELLS BY PODOPHYLLIN, 

FOLLOWED BY TEMPORARY REGRESSION AND PROLONGA 

TION OF LIFE OF TUMOUR-BEARING RATS. J. Nat. 

Cancer Inst., 1953. 13: 1185-1199. 3 pi. 

24 refs. 

2782 

Makino, S. and Tanaka, T. PRELIMINARY EXPERI 

MENTS ON GROWTH INHIBITION BY PODOPHYLIN 

[SIC] IN THE ASCITES-TUMOR OF RATS. Gann, 

Tokyo, 1952, 43: 164-166. In English. 

2783 

Uakino, S., Kano, K. and Tanaka, T. FURTHER 

DATA FROM THE SINGLE-CELL INOCULATION EX 

PERIMENTS IN THE HIROSAKI-SARCOMA. Gann, 


2784 

Muftoz, J. M., SÃ¡nchez Caballero, H. J., Bosq, p. 

and Vasena, J. ACCIÃ“N DEL PODOFILINO SOBRE 

EL SARCOMA EXPERIMENTAL. [ACTION OF PODOPHYLLIN 

ON EXPERIMENTAL SARCOMAS.] Medicina, 

1950, 10: 269-278. 53 refs. English 

B. Air.. 

summary. 

Abstracted in: Chem. Abstr., 1951, 45: 1229c. 

2785 

Ormsbee, R. A., Cornman, I. and Berger, K. E. 

EFFECT OF PODOPHYLLINON TUMORCELLS IN 

TISSUE CULTURE. Proc. Soc. Exp. Biol., N. Y., 

1947, 66: 586-590. 12 refs. 


PROCESSES) 

2787 

Miller, Z. B., Davison, C. and Smith, P. K. 

THE EFFECT OF PODOPHYLLOTOXINON TISSUE META 

BOLISM AND ENZYMESYSTEMS. J. Exp. M 1949 

90: 525-541. 30 refs. Abstracted in: Biol.' 

ADstr., 

Abstr., 

Bait., 

1950, 44: 

1950, 

21275". 

24: No. 6326: Chem 


2788 

Â»King, L. E. and Cauldwell, E. W. STUDIES ON 

THE MECHANISMSOF PODOPHYLLINACTION ON 

TUMORSANDNORMALSKIN. Proc. Inst. M. 

Chicago, 1948-1949, 17; 363. 


2789 

Algire, G. H., Legallais, F. Y. and Anderson, 

B. F. VASCULAR REACTIONS OF NORMAL AND MALIG 

NANT TISSUES IN VIVO. VI. THE ROLE OF HYPO 

TENSION IN THE ACTION OF COMPONENTS OF PODO 

PHYLLIN ON TRANSPLANTED SARCOMAS. 

Cancer Inst., 1954, 14: 879-893. 

J. Nat. 

3 pi. 15 

refs. Abstracted in: Excerpta med., Sect. 

16. 1954, 2: No. 2168. "Evidence was ob 

tained thai" the hypotensive effects of podo 

phyllin and of podophyllotoxin, on the peri 

pheral circulation of the host, seem to be 

sufficient to account for the observed tu 

mour damage following injection of these 

substances." 

SYNERGISTIC 

ACTION 

2790 

SÃ¡nchez Caballero, H. J. ACCIÃ“N SINÃˆRGICA DE 

ALGUNAS HORMONAS ESTEROIDES CON EL PODOFILINO 

SOBRE EL DESARROLLO DEL SARCOMA EXPERIMENTAL. 

[SYNERGISTIC ACTION OF SOME STEROID HORMONES 

WITH PODOPHYLLIN ON THE DEVELOPMENT OF EX 

PERIMENTAL SARCOMA.] Medicina, 

13: 367-378. 44 refs. English 

B. Air., 

summary. 

1953 

The 

hormones with podophyllin produce a greater 

decrease in weight of the tumors than does 

podophyllin alone and in larger doses. The 

most effective of the hormones in combination 

was estrogen. The experiment was made with 

60 rats, naie and female, with sarcomas. 

THERAPY 

2791 

Ballarati, U. IL TRATTAMENTO LOCALE E GENERALE 

DELLE NEOPLASIE CON PODOFILLINA. [LOCAL AND 

GENERAL TREATMENT OF TUMORS WITH PODOPHYLLIN]. 


2786 

Sullivan. M. TREATMENT OF CUTANEOUS CARCINOMA 

WITH PODOPHYLLIN. 

1949, 85; 200-203. 

Bull. Johns Hopkins Hosp., 

10 refs. Brief observa 

tions on the manner in which cutaneous carci 

nomas undergo involution following topical 

application of podophyllin. 

See 

15 922 

See 

1 

EFFECT 


2792 

Binazzi, M. COMPORTAMENTOISTOLOGICO ED IS- 

TOTIPICO DI NEOPLASIE DELLA CUTE DI FRONTE 

ALL'AZIONE DEGLI AOTIIIITOTICI. V. AZIONE 

DELLA PODOFILLINA PER INFILTRAZIONE LOCALE. 

[ HISTOLÃ“GICA!, ASPECT OF CANCER OF FRONTAL 

SKIN FOLLOWING ADMINISTRATION OF ANTIMITO- 

TICS. V. EFFECT OF PODOPHYLLIN IN LOCAL 

INFILTRATION.] Rass. derm. sif.. 1952, 

5: 219-226. 21 refs. 

2793 

Bosq, P. and SÃ¡nchez Caballero, H. J. RESULT 

ADOS INMEDIATOS .DEL TRATAMIENTO 

EPITELIOMAS CUTÃ•NEOS CON RESINA 

DE 

DE 

LOS 

PODO 

FILINO. [PODOPHYLLIN RESIN IN THERAPY OF 

EPITHELIOMAS; EARLY RESULTS.] Rev. argen. 

der. sif., 1952, 36: 43-46. 25 refs.



161 

PODOPHYLLIN 


(Continued) 

2794 

Bucalossi, P. and Di Pietro, S. LA PODOFILLINA 

E I SUOI PRINCIPI ATTIVI NELLA CURA DEL CAN 

CRO. CONTRIBUTO CLÃ•NICO. [PODOPHYLLIN AND ITS 

ACTIVE COMPONENTS IN THE TREATMENT OF CANCER 

(CLINICAL STUDY)]. Minerva med. ,Tor., 1952, 

43: pt. 1, 532-538. 28 refs. Twenty cases 

of spino- and baso-cellular carcinoma of the 

skin treated with local applications of podophyllin 

are reported. 

2795 

Bunge, R. G. PODOPHYLLIN IN TREATMENT OF HUMAN 

ADENOCARCINOMA OF BLADDER. J. Urol., 1952, 

68: 475-476. 

2796 

Dabrowsky. G. LECZENIE ZACHOWAWCZE BRODAWCZAKÃ“W 

KRTANI ÃœDZIEC1. [CONSERVATIVE TREATMENT OF 

PAPILLOMA OF THE LARYNX 

polska, 1953, 7: No. 4, 

IN CHILDREN.] Otolar. 

299-301. 7 refs. 

English summary. "Local application of podophyllin 

in 8 children with papillomas of the 

larynx resulted in one case of complete re 

covery, 4 cases of partial 

cases of no improvement." 

recovery and 3 

2797 

Ferrari, A. V. PODOFILLINA E TUMORI CUTANEI. 

[PODOPHYLLIN AND TUMORS OF THE SKIN.] 

Minerva derm. Tor., 1953, 28: 318. Abstracted 

in: Excerpta med., Sect. 1B7 1954, 2: No. 5310. 

2798 

Garb, J. SUPERFICIAL EPITHELIOMAS TREATED WITH 

PODOPHYLLIN. 

60: 806-807. 

Arch. Derm. Syph., Chic., 1949, 

2799 

GÃtzen, F. J. ZUR BEHANDLUNG VON BLASENTUMOREN 

MIT PODOPHILLIN. [PODOPHYLLIN TREATMENT OF 

BLADDER TUMORS]. Zschr. Urol., 1953, 46: 

467-470. No results were obtained in leases 

of bladder papilloma and 

carcinoma of the bladder 

2 cases 

treated 

of inoperable 

with podophyllin. 

2800 

Graciansky, P. de and Grupper, C. TRAITEMENT 

DES Ã‰PITHÃ‰LIOMAS CUTANÃ‰SPAR LA PODOPHYLLINE. 

[TREATMENT OF CUTANEOUS EPITHELIOMAS WITH 

PODOPHYLLIN]. Bull. Soc. fr. derm, syph., 

Par., 1951, 58: 393-395. 

2801 

J0rgsholm, B. PRELIMINARY EXPERIENCES WITH PODO 

PHYLLIN IN THE TREATMENT OF SKIN CARCINOMATA. 

Acta radiol., Stockh., 1952, 37: 150-160. 28 

refs. Abstracted in: Chem. Abstr., 1952, 46: 

No. 5713d. 

2802 

Â«Kern, A. B. and Fanger, H. PODOPHYLLIN IN THE 

TREATMENT OF CUTANEOUS CARCINOMA. A.M.A. 

Arch. Derm. Syph., Chic., 1950, 62: 526-532. 

2803 

Larsson, L. G. BASAL-CELL CARCINOMAS OF THE 

SKIN TREATED BY LOCAL PODOPHYLLIN APPLICATIONS; 

A PRELIMINARY REPORT. Acta radiol., 1950, 

34: 449-452. 8 refs. Compare with the au 

thor's article in Acta derm, vener., Stockh., 

1952, 32: 56-73, the substance of which is 

essentially the same as that of this article 

but in greater detail. 

2804 

Larsson, L. G. PODOPHYLLIN TREATMENT OF SKIN 

CARCINOMAS. Acta 

1952, 32: 56-73. 

derm, vener., Stockh., 

57 refs. Podophyllin ap 

plied locally gave good primary results in 

treatment of precancerous dermatosis and 

extensive, superficial basal-cell carci 

nomas but not in the more infiltrative type 

of tumor. Gross and microscopic changes 

found during treatment are described. 

2805 

Nicolov. N. DIE BEHANDLUNG DER HAUT- UND LID 

KARZINOME MIT PODOPHYLLIN. [PODOPHYLLIN IN 

THE TREATMENT OF CARCINOMA OF THE SKIN AND 

THE PALPEBRAE.] Krebsarzt, Wien, 1953, 8: 

334-339. 5 refs. 

2806 

Nicolov, N. ÃœBERDEN WERT DER BEHANDLUNG DER 

BASALZELKARZINOME MIT PODOPHYLLIN. [VALUE 

OF PODOPHYLUN THERAPY OF THE BASAL CELL 

CARCINOMA.] Fortsch. Rontgenstrahl., 1953, 

79: Suppl., 54-55. 

2807 Rscchietta, S. AZIONE ANTINEOPLASTICA DELLA 

PODOFILINA. [ANTI-NEOPLASTIC ACTION OF 

PODOPHYLLIN.] Boll, chira, farm., 

187-189. 8 refs. A review. 

1952, 91: 

2808 Sims, C. F. and Pensky, N. EFFECTS OF PODO- 

PHYLLUM ON BASAL-CELL EPITHELIOMAS. A.H.A. 

Arch. 

3 pi. 

Derm. Syph., Chic., 1951, 64: 142-148. 

12 refs. "Twenty cases ol~basal-cell 

epithelioma were treated with podophyllum 

resin in mineral oil in alcohol for a period 

of two to seven days. No regression or cures 

were observed in any case." 

2809 

Smith, L. M. and Garrett, H. D. RESIN OF PODO 

PHYLLUM IN TREATMENT OF CANCEROUS AND PRE 

CANCEROUS CONDITIONS OF SKIN; EFFECT ON 

BASAL CELL EPITHELIOMA AND SEBORRHIC, SENILE 

AND RADIATION 

Syph., Chic., 

KERATOSIS. Arch. Derm, 

1950, 61: 946-956. 

and 

2810 

Sullivan, M., Zeli, L. and McCulloch, H., Jr. 

FAILURE OF PODOPHYLLIN IN THE TREATMENT OF 

CUTANEOUS CARCINOMA. Bull. Johns Hopkins 

Hosp., 1952, 90: 368-371. 9 refs. "Treat 

ment of cutaneous basal and prickle cell 

carcinomas with podophyllin is dangerous and 

misleading as demonstrated by 100% recurrences 

of treated tumors in 6 and 22 months. The 

method should be used only as an experimental 

procedure for small 

liomas..." 

intraepidermal epithe- 

2811 

Touraine, A. LA PODOPHYLLINE EN THÃ‰RAPEUTIQUE. 

[THERAPEUTIC USE OF PODOPHYLLIN.] 

Par., 1950, 5: 178-191. 90 refs. 

ThÃ©rapie, 

2812 Vilanova, X. and Comas, F. LA RESINA DE PODO- 

FILINO Y LA PODOFILINOTOXINA EN EL TRATA 

MIENTO DEL EPITELIOMA CUTANEO. [PODOPHYLLIN 

RESIN AND PODOPHYLLOTOXIN IN THERAPY OF CU 

TANEOUS EPITHELIOMA.] Med. clin., Barcel., 

1952, 18: 352-361. 110 refs. 

2813 Wyss-Chodat, F. UNE NOUVELLE METHODE DE TRAITE 

MENT DES Ã‰PITHÃ‰LIOMAS:LA PODOPHYLLINOTHERAPIE 

(PELTACURE). [A NEW METHOD OF TREATMENT OF 

EPITHELIOMAS: PODOPHYLLINOTHERAPY (PELTACURE).] 

Schweiz, med. Wschr., 1950, 80: 647-651. 4 refs. 

In ten patients podophyllin applied directly 

to epitheliomas caused complete repression of 

tumors. Necrotic action seemed specific, as 

normal surrounding tissue remained unaffected. 

2814 yss-Chodat, F. and Feinmann, J. DE L'ACTION 

DE LA PODOPHYLLINE SUR UN CANCROIDE. [THE 

EFFECT OF PODOPHYLLIN ON A CASE OF CANCROID.] 

Rev. mÃ©a. Suisse rom., 1948, 68: 613. 

See 

2777 2786



162 

PODOPHYLLIN 

â€”¿ TOXICITY 

2815 

Calabrese, A. I. ESTUDIO TOXICOLOGICO EXPERI 

MENTAL, SOBRE PODOFILOTOXINA. SU APLICACIÃ“N 

EN CLÃ•NICA ONCOLOGICA POR VIA PARENTERAL. 

[EXPERIMENTAL TOXICOLOGY OF PODOPHYLLIN. ITS 

USE 

med. 

IN PARENTERAL TREATMENT OF CANCER.] 

B. Air., 1951, 58: 1034-1036. 

Sem. 

2816 

Holczinger, L. and Kellner, B. THE EFFECTS OF 

ACUTE AND CHRONIC PODOPHYLLIN POISONING ON 

THE ORGANS OF THE RAT. Acta morph. hung., 

1953, 3: 305-323. 37 refs. Cellular changes 

occurrTng in acute and chronic podophyllin 

poisoning on 70 male rats are reported. 

Changes occurred mainly in organs with high 

mitotic frequency. Antimitotic effect is 

observed in the metaphase. Authors claim 

that protracted administration with identi 

cal doses of podophyllin 

resistance to compound. 

does not bring about 

Reticular hyperplasia, 

giant cell formation, azoospermia, 

etc. are some of the permanent changes 

appearing as a consequence of chronic podo 

phyllin poisoning. 

2817 Jarraras, A. G. COMPLICATIONOF PODOPHYLLIN 

THERAPY. Brit. M. J., 1949, 1_: 780. 

"Approximately 50% of the podophyllin [ad 

ministered] was...returned in the form of 

the calculi." 

2818 MacCardle, R. C. and Perrault, A. DEGENERATION 

OF CEREBELLAR PURKINJE CELLS IN TUMOR-BEARING 

ANIMALS AFTER SUBCUTANEOUS INJECTION OF PODO 

PHYLLIN. Acta UniÃ³ internat, cancr., Louvain, 

1949, 6: 539-541. 

2819 Sullivan, M., Follis, R. II , Jr. and Hilgartner, 

M. TOXICOLOGYOF PODOPHYLLIN. Proc. Soc. 


Abstracted in: Chem. AbstfT, 1951, 45: 81371. 

â€”¿TOXICITY, COUNTERACTION TO 

See 

883 

PODOPHYLLOTOXIN 

See 

846 2767 




282U 

Tanaka, T., Kano, K., Tonomura, A., Okada, T. A. 

and Umetani, M. THE CYTOLOGICAL EFFECT OF 

CHEMICALS ON ASCITES SARCOMAS. III. DAMAGE 

INDUCED BY PODOPHYLLOTOXIN, ALPHA-PELTATIN, 

BETA-PELTATIN AND QUERCETIN. Gann, Tokyo, 

1955, 46: 15-26. 8 refs. 

2821 Veronesi, U., di Pietro, S. and Sirtori, C. 

ATTIVITÃ€ DELLA PODOFILLOTOSSINA SUI TUMORI 

CUTANEI SPERIMENTALI DA BENZOPIREUE NEL 

TOPO. [THE INFLUENCE OF PODOPHYLLOTOXIN 

ON SKIN TUMORS INDUCED IN MICE BY MEANS OF 

BENZPYRENE.] Boll. Soc. ital. pat., Tor., 

1954-1955, 4: 43-46. 16 refs. Abstracted 


3091. 

See 

Waterman, N. ON SOME CHEMOTHERAPEUTIC EXPERI 

MENTS WITH PODOPHYLLOTOXIN. Acta physiol. 

pharm. neerl., 1950, 1: 638-644. 9 refs. 


5: No. 518. 

2686 2765 2779 


PROCESSES) 

2823 

Waravdekar, V. S., Domingue, A. and Leiter, J. 

EFFECT OF PODOPHYLLOTOXIN. ALPHA-PELTATIN 

AND BETA-PELTATIN ON THE CYTOCHROME OXIDASE 

ACTIVITY OF SARCOMA 37. J. Nat. Cancer Inst., 

1952, 13: 393-407. 15 refs. 

2824 Waravdekar, V. S., Paradis, A. D. and Leiter, J. 

ENZYME CHANGES INDUCED IN NORMAL AND MALIGNANT 

TISSUES WITH CHEMICAL AGENTS. III. EFFECT 

OF ACETYLPODOPHYLLOTOXIN-iÂ»-PYRIDINIUM CHLORIDE 

ON CYTOCHROME OXIDASE, CYTOCHROME C, SUCCINOXI- 

DASE, SUCCINIC DEHYDROGENASE, AND RESPIRATION 

OF SARCOMA 37. J. Nat. Cancer Inst., 1953, 

14: 585-592. 14 refs. 

See 

73 2213 

THERAPY 

2825 

Â«Penati, t., Lovisetto, P. and Turco, G. L. 

LA PODOFILLOTISSINA NELLE LEUCEMIE. [PODO 

PHYLLOTOXININ LEUKEMIAS.] Gior. ital. 

chemioter., 1954, 1_: 177-179. Abstracted 


3218. 

2812 2815 

POISON IVY 

See 

926 

POLYDYN â€”¿ THERAPY 

2826 Grewe, H. E. and SchÃ¼tter, H. E. ZUR UNSPEZI- 

FISCHEJJ KREBSTHERAPIE SOWIE ERFAHRUNGEN MIT 

DEM PRÃ„PARATPOLYDYN. [NON-SPECIFIC CANCER 

TREATMENT AND EXPERIENCE WITH THE PREPARATION 

POLYDYN.] Aerztl. Wschr., 1953, 8: 254-257. 

53 refs. 

2827 

GrUneis, P. PRUFUNGSERGEBNISSE DER POLYDYN- 

BEHANDLUNG BEI KREBSKRANKEN. [TEST RESULTS 

OF TREATMENT OF TUMOR PATIENTS WITH POLYDYN.] 

Wien. med. Wschr., 1952, 102: 1023-1025. 5 

refs. Twenty patients with carcinomas were 

treated with polydyn (elpimed). No tumor 

growth regression could be observed. 

2828 

Jelinek, R. UNSERE ERFAHRUNGEN MIT POLYDYN BEI 

BÃ–SARTIGEN GESCHWÃœLSTEN. [OUR EXPERIENCES 

WITH POLYDYN IN MALIGNANT TUMORS.] Wien. med. 

Wschr., 

fluence 

1953, 103: 207-208. 

on tumoT~~growth was 

6 refs. 

observed 

No in 

in 12 

cases of carcinoma and sarcoma; the general 

condition was improved in some cases. 

2829 Keudel, W. EINJÃ„HRIGE BEOBACHTUNG NACH POLY- 

DYNBEHANDLUNG. [A YEAR'S OBSERVATION OF 

POLYDYN TREATMENT.] Medizinische, 1954, 

No. 27-28. 956-961. 10 refs. Treatment 

of 24 cases of malignant tumors resulted in 

no improvement, had possibly a growth pro 

moting effect. "Therefore, polydyn is to 

be regarded as absolutely unsuitable for 

the treatment of malignant tumors." -TransÃ.



163 

POLYDYN â€”¿ THERAPY 

(Continued) 

2830 

Kment, A. ÃœBER DIE BEEINFLUSSUNG DER BINDEGEWEBS 

(R.E.S.)-UND GEFÃ„SSFUNKTIONEN DURCH GEWEBSEX 

TRAKTE. [THE EFFECT OF TISSUE EXTRACTS UPON THE 

FUNCTIONS OF THE CONNECTIVE TISSUE, (R.E.S.) 

AND BLOOD VESSELS.] Wien. med. Wschr., 1952, 

10^: 284-287. 31 reÃs. 

2831 

Lindner, E. ERFAHRUNGEN MIT POLYDYN. EX 

PERIENCES WITH POLYDYN]. Wien. med. Wschr., 

1952, 102: 589-591. 2 refs. In 12 patients 

with various tumors polydyn treatment had no 

effect on tumor regression. Beside diuretic 

effects polydyn improved the overall condi 

tion of the patients. 

2832 

Schaffer, K. ERGEBNISSE DER BEHANDLUNG VON 

KARZINOMREZIDIVEN MIT POLYDYN. [RESULTS IN 

THE TREATMENT OF CARCINOMA RELAPSES WITH 

POLYDYN.] 

287-290. 

Â«fien.med. Wsphr., 1952, 102: 

3 refs. In 38 female adulÃ¯s~ten 

to twenty polydyn injections caused dis 

appearance of the mÃ©tastases, and check of 

weight loss. Pain subsided following 3-5 

injection. 

2833 

Wessely, E. A. ERFAHRUNGEN MIT POLYDYN. [EX 

PERIENCES WITH POLYDYN.] tiien. med. Wschr.. 

1952, 102: 727-729. Negative results in a 

case oÃ¯cancer of the tongue. 

POLYSACCHARIDES 

see also BACTERIA. POLYSACCHARIDES 

BACTERIA. SERRATIA MARCESCENS POLY- 

SACCHARIDE 

2834 

Fukushima, T. MY POLYSACCHARIDE THERAPY OF 

HUMAN CANCER AND THE STUDY ON POLYSACCHARIDE 

BY HAUASHIMA ET AL. Gann, Tokyo, 1954, 4j5: 


2835 

Fukushima, T. A NEW HYPOTHESIS CONCERNING UN 

KNOWN ACTIVE AGENTS OF CERTAIN CANCER-INHI 

BITING SUBSTANCES REPORTED IN THE LITERATURE. 

Gann, Tokyo, 1952, 43: 338-340. In English. 


"The activity of a number of 

1955, 49: 4801. 

cancer^Ã¯nhibiting 

substances is attributed to their mucopolysaccharide 

content which presumably causes 

precipitation of biologically essential pro 

teins. Cancer cells are more susceptible to 

this action than normal cells because they 

are more acidic and 

enzymes than normal 

contain 

cells." 

less essential 


2836 

Fukushima, T. SOME SUPPLEMENTS TO THE POLY 

SACCHARIDE HYPOTHESIS CONCERNING THE DEVE 

LOPMENT, THERAPY AND PROPHYLAXIS OF CANCER. 


2837 

Hamashima, Y., Kanamori, H. and Kunieda, Y. 

EFFECT OF POLYSACCHARIDE ON THE YOSHIDA SAR 

COMA CELLS (PRELIMINARY REPORT). Gann. 

1953, 44: 437-443. 2 pi. 11 refs. In 

Tokyo, 

EnglisHT 

2838 

Takashi, S., Matso, H., Ishida, H. and Miyaji, 

T. THE EFFECT POLYSACCHARIDE UPON THE EHRLICH 

ASCITES CARCINOMA. Gann, Tokyo, 1954, 45: 

552 554. In English. Polysaccharides extracted 

from various tissues were injected into the 

peritoneal cavity of Ehrlich carcinoma bearing 

mice, in doses of 1 mg each. Polysaccharides 

from Ehrlich ascites carcinoma were observed 

to have the most inhibitory effect, destroying 

69% of tumor cells 3 hours following the in 

jection. 

POLYSACCHARIDES, 

SULFOMUCO _ 

2839 

Balazs A. and Holgren. Hj. EFFECT OF SULFO- 

MUCOPOLYSACCHARIDES ON GROWTH OF TUMOR TISSUE. 


145. Sulfomucopolysaccharides(sodium~"heparinate 

and sodium of agar acid)suppress in 

vitro the growth of cells from methyl cholanthrene 

tumors of the rat. Injections of 

the substances increased the survival time 

of mice previously innoculated with sus 

pension of cells from Ehrlich's carcinoma. 

POTASSIUM 

CHLORIDE 

2840 

Espona, J. EL TRATAMIENTO DEL CANCER CON 

CLORURO POTÃ•SICO Y SU ADMINISTRACIÃ“N POR 

VIA INTRADERMICA. [TREATMENT OF CANCER 

WITH POTASSIUM CHLORIDE AND ITS INTRADERMAL 

ADMINISTRATION]. Med. espaB., 1948, 20- 

513-118. 6 refs. 

POTASSIUM 

CYANIDE 

2841 Szam, I., Hankovszky, M., Eckhardt, S., JancsÃ³, 

G. and Selle,!, C. AZ URETHAN DAGANATNÃ–VEKEDE'ST 

GATLÃ“ HATASANAK BEFOLYA' SOLJÃ•SACYANKALIUMMAL. 

[EFFECT OF POTASSIUM CYANIDE ON THE INHIBITORY 

EFFECT OF URETHANE ON THE GROWTH OF TUMORS.] 

KisÃ©rletes orvostud., 1952, 4: 256-259. 26 refs. 

The effects of tumor-inhibiting potassium cyanide 

in doses of 0.007-0.011 mg/kg and mitosis-inhi 

biting urethane in doses of 0.5/g kg were studied 

in 27 sarcomatous animals (mostly rats). Ure 

thane was most effective when given alone. When 

urethane was given in conjunction with potassium 

cyanide, because of the latter's antagonistic 

effect upon the former compound, urethane was 

not so effective. 

POTASSIUM 

FLUORIDE 

2842 

Finerty, J. C. and Grace, J. D. EFFECT OF 

FLUORIDE ON TUMOR GROWTH. Texas 

M., 1952, 10: 501-503. 3 refs. 

Rep. Biol. 

"Rats which 

had receive? implants of the Walker rat sar 

coma 319 were given various amounts of po 

tassium fluoride in their drinking water. 

There 

tumor 

was no inhibition 

growth." 

nor stimulation of 

POTASSIUM 

IODIDE 

2843 

Berg, O., Gordon, M. and Gorbman, A. COMPARA 

TIVE EFFECTS OF THYROIDAL STIMULANTS AND IN 

HIBITORS OF NORMAL AND TUMOROUS THYROIDS IN 

XIPHOPHORIN FISHES. Cancer Res., 1954, 14: 

527-533. pi. 20 refs. Abstracted in: ~ 


PREPARATION 12,669A 

see COLCEMID 

PRODUCT "816" 

2844 

Lacour, F. CONTRÃ”LE EXPÃ‰RIMENTAL DU PRODUIT 

DÃ‰NOMMÃ‰'8161. [EXPERIMENTAL TESTS OF THE 

PRODUCT '816'.] Bull. Ass. fr. cancer, 


med., Sect. 5, 1952, 5: No. 2706. 

PROFLAVIN 

See 

24



164 

PROPANE, 

1,3-BIS(ETHYLENEIMINOSULPHONYL)- 

2845 Paterson, E. and Kunkler, P. B. THE EFFECT OF 

l:3-BIS(ETHYLENEIMINO SULPHONYL)PROPANE IN 

ANIHAL TUMOURS AND HUMANLEUKAEMIA. In: 

Ciba Foundation Symposium on leukemia re 

search, London, 1953, (Wolstenholme, G. E. W. 

and Cameron, M. P., edsâ€ž). Boston, Little, 

Brown and Co,, 1954, 231-243. Discussion: 

p. 240-243. pi. rÃ©f. 

1, 2-PROPANEDIOL, DIMETHANESULFONATE - 

2846 

Carlson, W. W. and Morgan, C. C. EFFECT OF 

CLYCOLMESYLATESON MOUSESARCOMA180. Proc. 

Soc. Exp. Biol., N. Y., 1954, 85: 211-213. 


PROPIOPHENONE, p-HYDROXY â€”¿ EFFECT ON TUMOR 

GROWTH 

2847 

Costa, E. and 

TAMENTO CON 

Ferrari, W. INFLUENZA 

PARAIDROSSIPROPIOFENONE 

DI UN TRAT 

SULL'AC 

CRESCIMENTO DI INNESTI DI CARCINOMA DI WALCKER 

PRATICATI NEL RATTO. [EFFECT OF PARAHYDROXY- 

PROPIOPHENONE ON THE GROWTH OF TRANSPLANTED 

WALCKER CARCINOMA IN RAT.] Boll. Soc. ital. 

biol. sper., 1952, 28: 1013-1015. para-Hydroxypropiophenone 

dTd not inhibit the tumor 

growth. 

2848 Robertson, C. H., Griffin, A. C. and Richardson, 

H. L. THE INHIBITORY ACTION OF P-HYDROXYPRO- 

PIOPHENONE ON HEPATIC CARCINOMA INDUCED BY 

AZO DYE. J. Nat. Cancer Inst., 1954, 15; 

519-527. 

See 


805 1030 


Cucinotta, U. OSSERVAZIONI CLINICHE SULL'AZIONE 

DEL PARAOSSIPROPIOFENONE IN QUATTRO CASI DI 

TUMORI MALIGNI. [CLINICAL STUDIES ON THE 

ACTION OF P-HYDROXYPROPIOPHENONE IN 4 CASES 

OF MALIGNANT TUMOUR.] Oncologia, Basel, 1954, 

7: 223-231. 40 refs. "Report on the results 

o"f treatment with paraoxypropiophenon in 4 

cases of malignant tumours: in 2 cases it was 

possible to arrest the tumour growth and to 

obtain regression of the neoplastic process. 

The regression of the metastatic lymph glands 

was, however, only temporary." 

2850 Debeyre, J. and Rudich, E. DEUX CAS DE TUMEUR 

GÃ‰NITALEMALIGNE Ã• TYPE DE CHORIO-EPITHELIOME; 

Ã‰CHECDU H 365. [MALIGNANT CHORIOEPITHELIO- 

MATOUS GENITAL TUMORS; FAILURE OF H 365.] 

Bull. 

231. 

Fed. soc. 

Discussion: 

gyn. 

p. 

obst. fr., 

230-231. 

2851 Haynal, E., Graf, F. and Matsch, E. POLYCY- 

THAEMIA AND ERYTHRAEMIA TREATED WITH PARA- 

HYDROXYPROPIOPHENONE. Lancet, Lond., 1953, 

l: 714-717. 

2852 Huguenin. R., Fauvet, J. and Pierart, A. NOU 

VELLE ETUDE SUR LA CHIMIOTHÃ‰RAPIEDU CANCER. 

EFFET DE LA PARA-OXY-PROPIO-PHÃ‰NONE SUR DES 

METASTASES PULMONAIRES. [NEW STUDIES ON THE 

CHEMOTHERAPY OF CANCER; EFFECT OF P-HYDROXY 

PROPIOPHENONE ON PULMONARYMETASTASES.] 

Bull. Soc. mÃ©d. hop. Paris, 1951, 67: 903- 

911. 

2853 

Â«Manconi, G. IL PARAOSSIPROPIOFENONE NEL TRAT 

TAMENTO DELLE METASTASI DEL CARCINOMA MAMMARIO. 

[P-HYDROXY-PROPIOPHENONE IN THE TREATMENT OF 

METASTAT1C MAMMARYCARCINOMA.] 

prat. Pavia, 1955, 10: 291-299. 

Farmaco, ed. 

2854 Perrault, M. ETAT ACTUEL DU H 365, PARA-OXY- 

PROPIOPHÃ‰NONE, FRENATEUR HYPOPHYSAIRE DE 

SYNTHÃˆSE. [PRESENT STATUS OF H 365. PARA- 

OXY-PROPIOPHENONE, SYNTHESIZED INHIBITOR 

OF THE HYPOPHYSIS.] Presse med., 1950, 58: 

1010-1013. 17 reÃs. 

2855 

Perrault. M., Vignalou, J. and Etienne, M. 

CHORIOEPITHELIOME MALIN (MÃ‰TASTASES PULMO 

NAIRES ACTIVES) TRAITÃ‰ AVEC DES RÃ‰SULTATS 

SATISFAISANTS, CLINIQUES, HORMONAUX ET 

RADIOLOGIQUES, PAR LE SEUL EMPLOI D'UN 

"FRENATEUR HYPOPHYSAIRE DE SYNTHÃˆSE," LE 

PARA-OXYPROPIO-PHÃ‰NONE (CORPS H-365), 

PENDANT 6 MOIS. [MALIGNANT CHORIOEPITHE- 

LIOMA (ACTIVE PULMONARY METASTASES) TREATED 

FOR SIX MONTHS WITH SATISFACTORY CLINICAL, 

HORMONAL 

SOLE USE 

AND RADIOLOGICAL RESULTS BY THE 

OF A "SYNTHESIZED HYPOPHYSIS 

INHIBITOR, " THE PARA-HYDROXYPROPIOPHENONE 

(H-365).] Bull. Soc. n,f.I hop. Paris, 1949, 


Tn~dex analyt. cancer., Par., 1951, 22: 

No. 237. 

2856 

Â»Royer, R. UN NOUVEL ESPOIR DANS LA THERAPEU 

TIQUE DU CANCER: LA PARA-HYDROXYPROPIOPHENONE. 

[A NEW HOPE FOR THE TREATMENT OF CANCER WITH 

P-HYDROXYPROPIOPHENONE.] Rev. quest, se., 

1951, 12: 588-591. 

PROPYLAMINES, 

DIPHENYL- 

2857 

Leiter, J., Hartwell, J. L., Kline, I. and 


WITH CHEMICAL AGENTS. VII. DIPHENYLPROPYL- 

AMINES, DIPHENYLPROPYLENEDIAMINES, DIPHENYL- 

ALKANES, AND RELATED COMPOUNDS. J. Nat. 


PROPYLENEDIAMINE, DIPHENYL- 

SM 

2857 

PROSTATE 

EXTRACT 

2858 Francese, A. ESTRATTI DI PROSTATA E TUMORI. 

[PROSTATE EXTRACTS AND TUMORS.] 

Tor., 1950, 4: 179-188. 5 refs. 

Neoplasie, 

Hydroglycerric 

extract of the prostate in doses of 

0.25 ce (corresponding to 30 mg of the 

fresh organ) injected into 18 male and 23 

female rats caused complete tumor regression 

in three rats, while in the rest of the 

animals the growth of the Ehrlich adenocarcinoma 

was inhibited only slightly. Sur 

vival time was prolonged and the decrease 

in body weight was reduced in all animals. 

PROSTIGMINE 

692



165 

PROTEINAMINE 

2859 

Brennan, M,. J.. Monto. R. W, . Jiangun, G. H. and 

Hartman, F. W. THERAPY OF Â«ALIGNANT DISEASES 

WITH PROTEINAMINE (A NEW AGENT). J. Laborat. 

Clin. M., 

[products 

1951, 38: 794-795. Proteinamine 

produced" by methyl-bis- /i-chloroethylamine 

coupled with plasma protein] was 

administered to 59 patients with various 

malignant neoplastia diseases. In 15 cases 

general improvement occurred. There were no 

notable side-effects. Best results were 

achieved in lymphogranulomatosis. 

PROTEINASE 

MENTS AS REPRESSORS OF CANCEROUS TUMORS.] 

Usp. sovrem. biol., 1949, 2]_\ 144-146. 

9 refs. Proteinase in doses of 0.5 ml was 

injected intraperitoneally to mice with 

Ehrlich ascites tumors. The growth of the 

tumors regressed, but the inhibiting effect 

of proteinase decreased as the number of 

injections increased. 

PTERIDINE, 

See 

1829 

PTERIDINE, 

2860 

Leontev, I. F. ZASHCHITNYE FERMENTY KAK PODA- 

VITELI RAKOVYKH OPUKHOLEI. [DEFENSIVE FER 

4-AMINO- 

2, 4-DIAMINO- 

2861 

Collier, H. O. J. and Phillips, M. SOME 2,4- 

DIAMINOPTERIDINES AS FOLINIC ACID ANTAGONISTS. 


Abstracted in: Chem. ABÃ¯tr., 1955, 49; 3417g. 

PTERINS â€”¿EFFECT ON MALIGNANT GROWTH 

See 

1384 EFFECT 3690 ON NORMAL GROWTH 

2862 

Bilek, O. VLIV PTERINÃš NA BILY KREVNÃ• OBRAZ. 

[INFLUENCE OF PTEHINS ON THE LEUCOCYTE COUNT.] 

Lek. listy, Brno, 1950, 5: 509-515. Tables, 


Chem. Abstr., 1955, 49: No. 


1210ÃŒ. "Leukemic 

mice were injected wITh pteridine, and a fall 

of leucocytes was observed in 75% of the 

animals. In the majority of mice a fall of 

lymphocytes was noted, whereas in others 

decrease in granulocytes was observed." 

a 

-Chem. Abstr. 

See 

2874 3691 


PROCESSES) 

2863 

Elion, G. B. and Hitchings, G. H. ANTAGONISTS 

OF NUCLEIC ACID DERIVATIVES. V. PTERIDINES. 


"The effects of thirty-four pteridines on the 

growth of Lactobacillus easel have been stu 

died in different media. All the 2, 4-diamino-and 

2-amino-4-alkylaminopteridines, a 

number of 2-amino-4-hydroxypteridines, and 

one 2-aminopteridine were found to be growth 

inhibitors in the folie acid-containing me 

dium. Some of the pteridines were also 

found to be inhibitory in a medium containing 

adenine and thymine. Many of these sub 

stances exhibit a greater inhibition in the 

presence of p-aminobenzoylglutamic acid than 

in its absence." 

2864 

Â»Sobchuk, B. A. VPLYV PTERYNIV NA SLOZNYVANNIA 

KUSNIU NORMAL'NYMY I PUKHLYNNYMY TKANYNAMY TA 

NA 

OF 

RIST PUKHLYN V ORHANIZMI TVARYN. 

PTERINS ON OXYGEN REQUIREMENT BY 

[EFFECT 

NORMAL 

AND TUMOR TISSUES AND ON GROWTH OF TUMORS IN 

THE ANIMAL ORGANISM.] 

1955, 27: 12-26. 

Ukrain. biokhim. zh. 

2865 

Swendseid, M. E., Wittle, E. L., Moersch, G. W., 

Bird, O. D. and Brown, R. A. HEMATOLOGIC 

EFFECT IN RATS OF PTERINS STRUCTURALLY RE 

LATED TO PTEROYLGLUTAMIC ACID. J. Biol. Chem., 

1949, 179: 1175-1182. 22 refs. 

TOXICITY 

2866 

Jacobson, W. and Pomerat, C. M. IN VITRO ASSAY 

OF TOXICITY OF PTERIN COMPOUNDS IN TISSUE CUL 

TURES. Texas Rep. Biol. M., 1949, 7: 88-91. 

tab. 

PTEROIC ACID, NlO-METHYL. 

See 

146 1035 2332 

FURINE, 2, 6-DIAMINO_ 

See 

3477EFFECT ON MALIGNANT GROWTH 

2867 

Biesele, J. J., Berger, R. E., Wilson, A. Y., 

Hitchings, G. H. and Elion, G. B. STUDIES 

ON 2,6-DIAMINOPURINE AND RELATED SUBSTANCES 

IN CULTURES OF EMBRYONIC AND SARCOMATOUS 

RODENT TISSUES. Cancer, N. Y., 1951, 4: 


Abstr., 1951, 45: 4821g. Tissue cultures 

of Crocker mouse sarcoma 180, T 

Ma 387 were selectively damaged 

241, and 

by 2,6- 

diaminopurine at concentrations causing 

little or no damage 

mouse-skin or heart 

to cultures of embryonic 

cells. Fetal rat-skin 

cultures were more sensitive to the purine 

than cultures 

carcinosarcoma 

of rat 

256. 

sarcoma R 39 or Walker 

Damage from diaminopurine 

could be prevented by adenine sulphate 

but not by hypoxanthine, xanthine, guanine, 

crotonoside (itself toxic), adenosine, 

muscle or yeast adenylic acids, guanylic acid, 

glycine, thymine, or pteroyglutamic acid 

(itself toxic). 

2868 

Burchenal, J. H., Bendich, A., Brown, G. B., 

Elion, G. B., Hitchings, G. H., Rhoads, C. P. 

and Stock, C. C. PRELIMINARY STUDIES ON THE 

EFFECT OF 2:6-DIAMINOPURINE ON TRANSPLANTED 

MOUSE LEUKEMIA. Cancer, N. Y., 1949, 2: 

119-120. 5 refs. In maximum doses, 2,6- 

diaminopurine 

leukemia Ak4 

was more effective against 

than methyl-bis (2-chloroethyl)- 

amine and approximately as effective as 4- 

amino-Nlo-methyl-PGA. 

2869 Skipper, H. E., Bennett, L. L., Jr., Edwards, 

p C Bryan, C. E., Hutchison, O. S., Chapman, 

JÂ°B. and Bell, M. ANTILUEKEMIC ASSAYS ON 

CERTAIN PYRIMIDINES, PURINES, BENZIMIDAZOLES, 

AND RELATED COMPOUNDS. Cancer Res., 1950, 10: 

166-169. 5 refs. Abstracted in: Chem. Absfr., 

1950, 44: 5477b. Of 17 compounds tested, only 

2,6 diÃ¢minopurine sulfate showed antileukemia 

activity in strain Ak 4. mice with lymphoid 

leukemia. The purine was less effective than 

aminopterin.



166 

PURINE, 2, 6-DIAMINO-, â€”¿ EFFECT 


See 

1333 EFFECT ON 1391NORMAL 1911 GROWTH 

ON MALIGNANT 

2670 

Cartsrright, G. E., Palmer, J. G., Hltchings, 

G. H.., Elion, G. B,, Gunn, F. D., and 

Wintrobe, M. M. 

6-DIAMINOPURINE 

STUDIES OF THE EFFECT OF 2, 

ON THE BLOOD AND BONE HARROW 

OF SWINE. J. Laborat. Clin. M., 1950, 35: 


ned., Sect. 2, 1951, 4: No. 1562. 

2871 

Dustin, P., Jr. ACTION ANTIMITOTIQUE, CHEZ LA 

SOURIS. DU LACTATE DE 2-6 DIAMINOPURINE. 

[ANTIMÃ•TOTIC ACTION OF 2,6-DIAMINOPURINE 

LACTATE IN THE MOUSE.] C. rend. Soc. biol., 


Chem. SbÂ¥tr., 1951, 4J54 No. 757e. 

2872 

Hertz, R. and Tullner, W. W. INHIBITION OF 

ESTROGEN-INDUCED GROWTH IN THE GENITAL TRACT 

OF THE FEMALE CHICK BY A PURINE ANTAGONIST; 

REVERSAL BY ADENINE. Science, 1949, 109: 

539. 9 refs. Abstracted in: Chem. AEsTr., 

1949, 4J3: 7103h. 

See 

1400EFFECTS, COUNTERACTION TO 

2873 


OF NUCLEIC ACID DERIVATIVES. IV. REVERSAL 

STUDIES WITH 2-AMINOPURINE AND 2 : 6-DIAMINO 

PURINE. J. Biol. Chem., 1950, 187: 511-522. 

21 refs. 

Sect. 2, 


1951, 4: No. 4647. "2-Amino-purine 

and 2 : 6-diamino-purine inhibit the growth 

of Lactobacillus casei in a folie acidcontaining 

medium. These compounds block 

the utilization of purine ribosides and 

ribonucleotides more effectively than that 

of the free purines. Studies are reported 

of the reversal of the inhibitory action by 

folie acid and the naturally 

rines." - Excerpta med. 

occurring pu 

2874 

Hertz, R. and Tullner, W. W. INTERFERENCE WITH 

HORMONAL EFFECTS BY ANTIVITAMINS AND COMPETI 

TION BETWEEN STRUCTURALLY SIMILAR STEROID HOR 

MONES. Ann. N. York 

1260-1273. 22 refs. 

Acad. Sc., 1950, 52: 

See 

364 2867 2878 

â€”¿METABOLISM (INCLUDING EFFECTS ON METABOLIC 

PROCESSES) 

2875 

Bendich, A. and Brown, G. B. 2,6-DIAMINOPURINE 

A PRECURSOR OF NUCLEIC ACID GUANINE. 

Chem., 1948, 176: 1471-1472. 4 refs. 

J. Biol. 

2,6- 

Diaminopurine was administered to rats at a 

level of 29mg per kilo per day for 3 days. 

Examination of the urinary constituents and 

the total nucleic acids of the viscera showed 

that 2,6-diaminopurine is a precursor of nu 

cleic acid guanine. Adenine and 2,6-diamino 

purine are toxic at levels at which other 

purines are non-toxic. 

2876 Bendich, A., FÃ¼rst, S. S. and Brown, G. B. 

ON THE ROLE OF 2,6-DIAMINOPURINE IN THE BIO 

SYNTHESIS OF NUCLEIC ACID GUANINE. J. Biol. 

Chem., 1950, 185: 423-433. 23 refs. Abstract 

ed in: Chem. AWtr., 1950, 44: 9998c. 

2877 

Brown, G. B. METABOLIC BASIS FOR OPTIMISM RE 

GARDING CHEMOTHERAPY WITH NUCLEIC ACID DERI 

VATIVES. In: Antimetabolites and cancer. 


Advanc. Sc., 1955, 285-299. 46 refs. 

2878 

Stock, C. C., Jacobson, W. and Williamson, M. 

AN INFLUENCE OF 2,6-DIAMINOPURINE UPON THE 

CONTENT OF KAPPA IN PARAMECIUM AURELIA, 

VARIETY 4. Proc. Soc. Exp. Biol., N. Y. 

1951, 78: 874-876. 24 refs. 

See 

See 

1829MODE OF ACTION 

1635 RESISTANCE TO 

See 

1636 2687 

THERAPY 

1639 TOXICITY 

2879 

Philips, F. S. and 

2,6-DIAMINOPURINE 

Thiersch, 

IN MICE, 

J. B. 

RATS, 

ACTIONS OF 

AND DOGS. 

Proc. 

408. 

Soc. Exp. 

12 refs. 

Biol., N. Y., 1949, 

"The administration 

72: 401- 

Ã–T large 

doses of 2,6-diaminopurine in mice and rats 

can result in death within a few hours. In 

dogs, large doses caused protracted vomiting, 

hemorrhagic diarrhea, dehydration and death 

within 48 hours. Doses permitting survival 

of rats and dogs for 24 hours or longer pro 

duced depletion of bone marrow and damage to 

epithelium of colon and ileum. The course 

of intoxication and changes in bone marrow 

permit a differentiation 

of 2,6-diaminopurine and 

between 

a folie 

the actions 

acid anta 

gonist like 4-aminopteroylglutamic acid." 

PURINE, 6-MERCAPTO- 

See 

2920 3367 3477 


2880 

Biesele, J. J. EFFECTS OF 6-MERCAPTO-PURINE 

ON EXPERIMENTAL TUMORS IN TISSUE CULTURE. 

Ann. N. York Acad. Sc., 1954, 60: 228-234 

5 refs. 

2881 

Biesele, J. J. ANTAGONISTIC EFFECTS OF 6- 

MERCAPTOPURINE AND COENZYME A ON MITOCHON 

DRIA AND MITOSIS IN TISSUE CULTURE. J. Biophys. 

refs. 

Cytol., 1955, 1: 119-126. 

"... at least one part of 

3 pi. 30 

the action 

by which 6-mercaptopurine decreases mitotic 

incidence in tissue cultures may be interfer 

ence on the part of 6-mercaptopurine, acting 

as an antimetabolite of coenzyme A, in mitochondrial 

function related to cell division."



167 

PURINE. 6-MERCAPTO-, â€”¿ EFFECT 


ON MALIGNANT 

- EFFECTS, COUNTERACTION TO 

2882 

Clarke Â« .& f-MER&URINE 

AND ANALOGS ON EXPERIMENTAL TUMORS. Ann. N. 

York Acad. So., 1954, 60: 235-43. 7 refs. 

2883 Clarke, D. A., Philips, F. S., Sternberg, S. S., 



168 

PURINE, 6-MERCAPTO-, â€”¿ THERAPY 

(Continued) 

2902 

Burchenal, J. H., Ellison, R. R., Murphy, M. L., 

Karnofsky, D. A., Sykes, M. P., Tan, T. C., 

Hermann, A. C., Yuceoglu, II., Meyers, W. P. L., 

Krakoff, I. and Alberstadt, N. 

DIES ON 6-MERCAPTOPURINE. Ann. 

CLINICAL STU 

N. York Acad. 

So., 1954, 60: 359-368. 11 reis. 

2903 

Burchenal, J. U., Karnofsky, D. A., Murphy, M. L., 

Ellison, Râ€žR., Sykes, M. P., Tan, C. T. C., 

Hermann, A. C., Yuceoglu, M. and Rhoads, C. P. 

CLINICAL EVALUATION OF 6-MERCAPTOPURINE IN THE 

TREATMENT OF LEUKEMIA. 

228: 371-377. 12 reis. 

Am. J. M. Sc., 1954, 

2904 

Burchenal, J. H., Murphy. M. L., Ellison, R. R., 

Sykes, U. P., Tan, [C.] T. C., Leone, L. A., 

Karnofsky, D. A., Graver. L. F.. Darjeon, H. W. 

and Rhoads, C. P. CLINICAL EVALUATION OF A 

NEW ANTIMETABOLITE, 6-MERCAPTOPURINE, IN THE 

TREATMENT OF LEUKEMIA AND ALLIED 

Blood, Bait., 1953, 8: 965-999. 

DISEASES. 

55 refs. 

Abstracted in: Leukemia Abstr., 1954, 2: No. 

454. 

2905 Daraeshek, W. THE USE OF 6-MERCAPTOPURINE IN 

ACUTE LEUKEMIA. Ann. N. York Acad. Sc., 

1954, 60: 447. 

2906 Demarsh, Q. B. THE TREATMENT OF LEUKEMIA WITH 

6-MERCAPTOPURINE. Ann. N. York Acad. Sc., 

1954, 60: 483-491. 

2907 

Doan, C. A., Wiseman, K. and Bouroncle, B. 

ONE-YEAR EVALUATION OF 6-MERCAPTOPURINE IN 

THE TREATMENT OF LEUKEMIA. Ann. N. York 

Acad. Sc., 1954, 60: 411. 

2908 Dubois-FerriÃ¨re, H. UN NOUVEL AGENT ANTILEUCE- 

MIQUE: 6-MERCAPTOPURINE. [A NEW ANTILEUKEMIC 

AGENT: 6-MERCAPTOPURINE.] J. med. Lyon, 1954, 


Sect. 16, 1955, 3: No. 191. 

2909 

Farber, S. SUMMARY OF EXPERIENCE WITH 6- 

MERCAPTOPURINE. Ann. 

1954, 6Â£: 412-414. 

N. York Acad. Sc., 

2910 

Fountain, J. R. CLINICAL OBSERVATIONS OF THE 

TREATMENT OF LEUKEMIA AND ALLIED DISORDERS 

WITH 6-MERCAPTOPURINE. Ann. N. York Acad. 

Sc., 1954, 60: 439-446. 

2911 Fountain, J. R. TREATMENT OF LEUKAEMIA AND 

ALLIED DISORDERS WITH 6-MERCAPTOPURINE. 

Brit. M. J., 1955, No. 4922, 1119-1124. 

11 refs. 

2912 

Gaffney, P. C. and Cooper, W. M. A CLINICAL 

STUDY OF 6-MERCAPTOPURINE. Ann. N. York 

Acad. Sc., 1954, 60: 478-482. 

2913 

Hall, B. E., Richards, M. D., Willett, F. M. 

and Feichtmeir, T. V. CLINICAL EXPERIENCE 

WITH 6-MERCAPTOPURINE IN HUMAN NEOPLASIA. 


3 refs. 

2914 Hall, B. E., Richards, M. D., Willett, F. M., 

Feichtmeir, T. V. and Aggeler, P. M. EVALUA 

TION OF 6-MERCAPTOPURINE IN THE TREATMENT OF 

LEUKEMIA; A PRELIMINARY REPORT. Stanford M. 

Bull., 1953, 11: 237-240. 4 refs. Results 

obtained in ir~cases. 

2915 

Hill, J. M. and Lajous, J. 6-MERCAPTOPURINE 

THERAPY IN LEUKEMIA. Ann. N. York Acad. 

Sc., 1954, 60: 461-465. 

2916 

Hyman, G. A., Gellhorn, A. and Wolff, J.A. 

THE THERAPEUTIC EFFECT OF MERCAPTOPURINE IN 

A VARIETY OF HUMAN 

Ann. N. York Acad. 

NEOPLASTIC 

Sc., 1954, 

DISEASES. 

60: 430-435. 

2917 

JimÃ©nez De AsÃºa, F. THE TREATMENT OF ELASTIC 

LEUKEMIAS WITH 6-MERCAPTOPURINE. Ann. 

N. York Acad. Sc., 1954, 60: 402-410. 

2918 

Â»Lenzi, G. PRIME IMPRESSIONI SU DI UN CASO DI 

LEUCEMIA ACUTA INFANTILE IN CORSO DI TRAT 

TAMENTO CON 6 MERCAPTOPURINA. [EARLY IM 

PRESSIONS OF A CASE OF ACUTE INFANTILE LEU 

KEMIA DURING 6-MERCAPTOPURINE THERAPY.] 

Minerva pediat., Tor., 1955, 7: 441. 

2919 Lozner, E. L. 6-MERCAPTOPURINE IN ACUTE LEU 

KEMIA. Ann. N. York Acad. Sc., 1954, 60: 

466-467. 

2920 

MERCAPTOPURINE IN LEUKEMIA. 

1955, 13: 120-121. 

Nutrit. Rev., 

2921 

Newton, W. A., Jr. CLINICAL EXPERIENCE USING 

6-MERCAPTOPURINE IN CHILDHOOD LEUKEMIA. 


2922 

Oehme, J. DIE BEHANDLUNG KINDLICHER LEUKOSEN 

MIT PURINETHOL. [PURINETHOL IN THE TREAT 

MENT OF CHILDHOOD LEUKEMIA.] Aerztl. Wschr., 

1955, 10: 14-17. 

2923 

Petrakis, N. L., Wood, D. A., Mettier, S. R., 

Deamer, W. C., Geliert, S. A., Li, J. G. and 

Leonard, M. E. THE EFFECT OF 6-MERCAPTO 

PURINE IN ACUTE LEUKEMIA OF CHILDREN AND 

ADULTS: A PRELIMINARY REPORT. Ann. N. York 

Acad. Sc., 1954, 60: 492-498. 8 refs. 

2924 

Pierce, M. LEUKEMIA IN CHILDREN: TREATMENT OF 

22 CASES WITH 6-MERCAPTOPURINE. Ann. 

N. York Acad. Sc., 1954, 60: 415-424. 

2925 

Pillow, R. P. CLINICAL NOTES ON THE USE OF 6- 

MERCAPTOPURINE IN ACUTE LEUKEMIA. Bull. 

Mason Clin., Seattle, 1954, 8: 64-69. 

2926 

Reymond, A. ESSAIS THERAPEUTHIQUES DE LA 6- 

UERCAPTOPURINE DANS LES LEUCOSES AIGUÃ‹S ET 

QUELQUES AUTRES HEMOPATHIES. [THERAPEUTIC 

TRIALS WITH 6-MERCAPTOPURINE IN ACUTE LEU 

KEMIA AND OTHER HEMOPATHIES.] 103p. Lyon, 

1955. (ThÃ¨se-Lyon) Bibliography: p. 99- 

103. The therapeutic value or the drug is 

evaluated in 53 cases. It was administered 

alone or in combination with antibiotics, 

cortisone or transfusions. Remissions of 

1-2 months were observed in cases of acute 

leukemia. 

2927 

Rice, E. C. RESULTS OBTAINED IN THE TREATMENT 

OF ACUTE LEUKEMIA AND LYMPHOSARCOMA WITH 6- 

MERCAPTOPURINE. Ann. N. York Acad. Sc., 

1954, 60: 458-460. 

2928 

Rice, E. C. and Bernstein, J. RECENT ADVANCES 

IN THE CHEMOTHERAPY OF LEUKEMIA AND MALIGNANT 

TUMORS OF CHILDREN. Clin. Proc. Child. Hosp., 

Wash., 1953, 9: 235-240. 6 refs. Abstracted 

in: Leukemia A'hstr., 1954, 2: No. 641. 

2929 Rosenthal, N., Rosenthal, R. L. and Lee, S. L. 

ROLE OF MERCAPTOPURINE IN THE TREATMENT OF 

LEUKEMIA AND RELATED DISEASES. Ann. N. York 

Acad. Sc., 1954, 60: 448-453. rÃ©f.



169 

PURINE, 6-MERCAPTO-, â€”¿ THERAPY 

(Continued) 

2930 Bundles, R. W. and Crago, J. A. 6-MERCAPTO- 

PURINE THERAPY IN NEOPLASTIC 

N. York Acad. So., 1954, 60: 

DISEASE. 

425-429. 

Ann. 

4 refs. 

2931 

Sawltsky, A. and Ream, C. R. CLINICAL EVALUA 

TION OF 6-MERCAPTOPURINE. Ann. N. York Acad. 

Sc., 1954, 60: 472-477. 4 refs. 

2932 

Sprague, C. C. TREATMENT OF LEUKEMIA. J. 

Louisiana M. Soc., 1954, 106: 445-450. 


2933 Sydenstricker, V. P. REPORT ON 6-MERCAPTO 

PURINE. Ann. N. York Acad. Sc., 1954, 

60: 454-457. 

2934 

TERAPIA DELLE LEUCEMIE CON UN NUOVO ANTIMETABO- 

LITA DELLE PURINE, 6-MERCAPTOPURINA. [TREAT 

MENT OF LEUKEMIA WITH A NEW PURINE ANTIMETA- 

BOLITE, 6-MERCAPTOPURINE.] Policlinico, sez. 

prat., 1954, 61: 1647-1649. 4 refs. 

2935 

Wilson, S. J. THE CLINICAL AND HEMATOLOGIC 

RESPONSE OF PREVIOUSLY TREATED LEUKEMIC 

SUBJECTS TO THE ANTIMETABOUTE 6-MERCAPTO 

PURINE. Ann. N. York Acad. Sc., 1954, 60: 

499-507. 9 refs. 

1135 

2740 

TOXICITY 

1489 1569 2045 2733 

2936 

Goldin. A., Venditti, J. M., Humphreys, S. R., 

Dennis, enns, D., Mantel, ane, N. . and Greenhouse, S. W. 

STUDIES ON THE TOXICITY ANDANTILEUKEMICACTION 

OF 6-MERCAPTOPURINEIN MICE. Ann. N. York 

Acad. Sc., 1954, 60: 251-266. 20 refs. 

2937 Philips, F. S., Sternberg, S. S., Hamilton, L. 

and Clarke, D. A. THE TOXIC EFFECTS OF 6- 

MERCAPTOPURINE 

N. York Acad. 

AND 

Sc., 

RELATED COMPOUNDS. 

1954, 60: 283-296. 

Ann. 

26 

refs. 

See 

2883 

- TOXICITY, COUNTERACTION TO 

2938 Goldin, A. DEMONSTRATIONOF PROTECTIONAGAINST 

THE LETHALTOXICITY OF 6-MERCAPTOPURINEIN MICE. 



5, 1955, 8: No. 805. 

FURINE ANALOGS 

2939 

Hitchings, G. H. STUDIES ON ANALOGS OF PURINES 

AND PYRIMIDINES. In: Antimetabolites and 

cancer. (Rhoads , C. P.. ed.) Washington, 

Am. Ass. Advanc. Sc., 1955, 231-241. 32 refs. 

See 

2937 2961 2962 

FURINE ANTAGONISTS 

See 

1017 

1637 

PURINES â€”¿ EFFECT 


2940 

Â»Waddington, C. H.and Mancuso, V. THE EFFECTS 

OF SOME PURINES USD PURI NE-ANALOGUES ON 

ASCIDIAN EMBRYOS. Ezp. Cell Res., 1955, 

9: 369-371. 4 refs. 

See 

2649EFFECT 


2941 

Barker, G. R., Dhar, M. M. and Parsons, L. D. 

THE EFFECTS OF INJECTION OF FURINE AND PY- 

RIMIDINE COMPOUNDS ON GRAFTED 

J. Cancer, 1949, 3J 427-429. 

MICE. Brit. 

6 refs. 


No. 8543c. 4-Aminouracil snowed a sig 

nificant inhibiting effect on transplanted 

tumors in mice. 

2942 

Biesele, J. J., Berger, R. E., Clarke, M. and 

Weiss, L. EFFECTS OF PURINES AND OTHER 

CHEMOTHERAPEUTIC AGENTS ON NUCLEAR STRUCTURE 

AND FUNCTION. Exp. Cell. Res., 1952, 

2: 279-303. Discussion: p. 301-303. 

Suppl., 

43 refs. 


12442a. The induction of chromosomaT damage 

and mitotic aberrations by alkylating agents, 

including nitrogen mustard and certain re 

lated compounds, were studied on onion root 

tips while the changes produced by purines 

were carried out chiefly on tissue cultures 

of Akm mouse embryonic skin and Crocker mouse 

sarcoma 180. 

2943 

Gordon, M., Siri, J. B. and Campbell, J. G. 

SCREENING OF POTENTIAL CANCER INHIBITING 

AGENTS. Science, 1951, 113: 61-64. 7 refs. 

Eleven purine and pyrimioTne derivatives 

were tested for inhibition of myeloid leu 

kemia C1498 and mammary adenocarcinoma Eo771 

in mice. None of the compounds showed cancer 

inhibiting activities. 

See 

1014 2662 2746 


PROCESSES) 

2944 

Brown. G. B. METABOLIC AND CHEMOTHERAPEUTIC 

STUDIES WITH PURINE DERIVATIVES. 

Rep. Biol. M., 1952, 10: 961-973. 

Texas 

31 refs. 

Diaminopurine either interferes with the 

early incorporation of adenine into some 

essential product or diaminopurine is in 

corporated into an analogous product by 

the same enzyme that is handling adenine. 

2945 Elion, G. B., Hitchings, G. H. and VanderWerff, 

H. ANTAGONISTS OF NUCLEIC ACID DERIVATIVES. 

VI. PURINES. J. Biol. Chem., 1951, 192: 

505-518. 9 refs. 

2946 


OF NUCLEIC ACID DERIVATIVES. III. THE 

SPECIFICITY OF THE PURINE REQUIREMENT OF 

LACTOBACILLUS 

185: 651-655. 

CASEI. J. Biol. Chem., 1950, 

9 refs. "The specificity of 

the purine requirement of Lactobacillus casei 

grown in a medium containing thymine has been 

examined. Position isomers of the natural 

purines do not support growth but often act 

as inhibitors. Among the methylated purines 

which were studied, only 1-methylguanine, 

1-methylxanthine, 8-methylguanine, and 6- 

methylaminopurine show some degree of purinelike 

activity."



170 

PURINES 

â€”¿ TOXICITY 

See 

2661 

PUROMYCIN 

2947 

Oleson, J. J., Bennett, P. L., Halliday, S. L. 

and Williams, J. H. THE EFFECT OF THE HY 

DROLYSIS PRODUCTS OF PUROMYCIN ON MOUSE 

MAMMARY TUMORS. Acta UniÃ³ internat, cancr., 

Louvain, 1955, 11: 161-166. 17 refs. "The 

carcinostatic acTivity of the hydrolysis pro 

ducts of puromycin have been determined against 

two mammary adenocarcinomas in mice. 

ducts of complete hydrolysis, namely 

The pro 

6-dimethyladenine, 

3-aminoribose and p-methoxyphenylalanine 

are inactive when given alone or 

in combination. The partial hydrolysis pro 

duct, namely the aminonucleoside, is appre 

ciably more 

biotic." 

effective than the parent anti 

2948 Wright, J. C., Dolgopol, V. B., Logan, M., 

Prigot, A. and Wright, L. T. CLINICAL 

EVALUATION OF PUROMYCIN IN HUMAN NEOPLASTIC 

DISEASE. A.M.A. Arch. Int. M., 1955, 96: 

61-77. 10 refs. Puromycin caused regression 

in tumor size in 14 of 51 patients, but did 

not alter "the patient's progressive downhill 

clinical course." 

See 

3360 

PYOCYANINE 

2Q49 LettrÃ© H. ZUR WIRKUNG VON ATMUNGSKATALYSATOREN 

AUF DIE ZELLTEILUNG. [EFFECT OF RESPIRATORY 

CATALYSTS ON CELL DIVISION.] Naturwissenschaften, 

1952, 39: 483. Abstracted in: Excerpta med., 

Sect. TB", 1954, 2: No. 581. 

295LÂ°e 

ittrÃ©,R. DRUG ACTION ON CELLS IN VITRO; 

EXHIBITION 

York Acad. 

OF A MOTION PICTURE. Ann. 

Sc., 1954, 513: 1085-1088. 

N. 

5 refs. 

PYRAZOLIDINE, 3, 5-DIOXY- l, 2-DIPHENYL-4- 

BUTYL- 

2951 Emich R. KLINISCHE ERFAHRUNGEN MIT BUTAZOLI 

DIN BEI NEOPLASTISCHEN PROZESSEN. CLINICAL 

EXPERIENCE WITH BUTAZOLIDINE IN NEOPLASTIC 

PROCESSES.] Wien. med. Wschr., 1955, 105: 

371-372. 12 refs. 

2952 Heilmeyer, L.. Harwerth, H. G., Doxie, J. and 

Kraus, R. KLINISCHE UND EXPERIMENTELLE UNTER 

SUCHUNGEN ÃœBER DIE WIRKUNGEN VON BUTAZOLIDIN 

UND SEINE ANWENDUNG BEI LEUKÃ„MIEN, NEOPLASTI 

SCHEN PROCESSEN UND LYMPHOGRANULOMATOSEN. 

[CLINICAL AND EXPERIMENTAL STUDIES ON THE 

EFFECTS PRODUCED BY BUTAZOLIDINE AND ON ITS 

USES IN LEUKEMIAS, NEOPLASTIC PROCESSES AND 

LYMPHOGRANULOMATOSES.l Arzneimitt. Forsch., 

1953. 3: 161-175. 26 refs. Abstracted in: 

Leukemia Abstr., 1953, 1: No. 218. A wide 

series of observations showed that the ef 

fects of butazolidine are purely symptomatic. 

The drug had, however, a strong antipyretic 

action. The antiphlogistic and analgesic 

effects are also notable and favorably in 

fluenced the general condition of the patient. 

2953 

Klima, R., Beyreder, J. and Herzog, E. ZUR 

WIRKUNG DES BUTAZOLIDIN BZW. IRGAPYRIN BEI 

DER LYMPHOGRANULOUATOSE UND ANDEREN BLUTKRANK 

HEITEN. [THE EFFECT OF BUTAZOLIDIN AND 

IRGAPYRIN ON HODGKIN'S DISEASE AND OTHER 

HEMOPATHIES.] Wien. med. Wschr., 1954, 104: 


med., Sect. 16, 1954, 2: No. 3930. "In 30 

of 36 cases of Hodgkin^s disease, lymphatic 

leukaemia, acute leukaemia and virus infections, 

oral administration of butazolidin or irgapyrin 

had a satisfactory antipyretic, analgetic and 

antiphlogistic effect. The possibility of a 

cytostatic effect is left undiscussed. An 

effect on the blood picture in leukaemia was 

not established with certainty. Therapeutic 

results are discussed with reference to 5 

cases." -Excerpta med. 

2954 

Rottino, A., Joffe, A. and Hoffmann, G. PHENYL- 

BUTAZONE (BUTAZOLIDIN), A USEFUL CHEMOTHERA- 

PEUTIC AGENT FOR HODGKIN'S DISEASE. Arch. 

Int. M., 1954, 93: 561-570. 5 refs. 

2955 

Stern, P. and Misirlija, A. UNTERSUCHUNGANTI- 

LEUKÃ„MISCHERSUBSTANZENAN DER HÃœHNERLEUKOSE. 

[EXPERIMENTSWITH ANTI-LEUKEMIC SUBSTANCES 

IN LEUCOSIS IN CHICKENS.] 

1955, 1^: 26-27. 5 refs. 

Experientla, Basel, 

PYRIDINE, 3-BIS(/3-CHLOROETHYL)AMINOMETHYL-4- 

METHOXYMETHYL-5-HYDROXY-6 METHYLsee 

NITROGEN MUSTARDS. PYRIDINE, 3-BIS(ÃŸ- 

CHLOROETHYL) AAONOMETHYL-4-METHOXY- 

METHYL-5-HYDROXY-6 METHYL- 

PYRIDINIUM CHLORIDE 

2824 

PYRIDOXINE 

See 

186 

PYRIDOXINE DEFICIENCY 

2956 

GrÃ©goire, C. EFFECTS OF PYRIDOXINE DEFICIENCY 

ON THE NORMAL AND NEOPLASTIC LYMPHOID TISSUE 

OF THE RAT. Arch, internat, pharm. dyn. 

Bruges, 1949, 78: 313-335. 28 refs. "The 

influence on the normal and malignant lymphoid 

tissues of the omission of pyridoxine in 

a synthetic diet, associated or not asso 

ciated with the administration of the anta 

gonist desoxypridoxine has been examined... 

The thymus was found to be more involuted 

and the tumor less developed in the deficient 

rats... Attempts to bring about a regression 

of 

of 

the growing tumor by means of large amounts 

desoxypyridoxine were inconclusive." 

2957 

Stoerk, H. C. THE REGRESSION OF LYMPHOSARCOMA 

IMPLANTS IN PYRIDOXINE-DEFICIENT MICE. J. 

Biol. Chem., 1947, 171: 437-438. 4 refs. 

See 

3187 

PYRIDOXINE, 

DESOXY- 

2957a 

Shapiro, D. M., Shils, M. E. and Dietrich, L. S. 

QUANTITATIVE BIOCHEMICAL DIFFERENCES BETWEEN 

TUMOR AND HOST AS A BASIS FOR CANCER CHEMO 

THERAPY. 

703-708. 

I. VITAMIN 

27 refs. 

B. Cancer Res., 1953, 13: 

"The data and pertinent 

literature are discussed as evidence for the 

hypothesis that the lower concentrations of 

metabolites in neoplastic tissue furnish a 

basis for 

agents." 

the selection of chemotherapeutic



171 

PYRIDOXINE, 

DESOXY- (Continued) 

29Stoerk, H. C. DESOXYPYRIDOXINEOBSERVATIONSIN 

"ACUTE PYRIDOXINE DEFICIENCY. Ann. N. York 

Acad. Sc., 1950, 52: 1302-1317. 24 refs. 

2959 

Weir, D. R. and Morningstar, W. A. THE EFFECT 

OF PYRIDOXINE DEFICIENCY INDUCED BY DESOXY 

PYRIDOXINE ON ACUTE LYMPHATIC LEUKEMIA OF 

ADULTS. Blood, Bait., 1954, 9: 173-182. 


16, 1954, 2: No. 4443. "Four patients 

Sect. 

diagnosed clinically as acute lymphatic leu 

kaemia were treated with desoxypyridoxine, a 

pyridoxine antagonist. 500-1400 mg of the 

drug were administered daily in divided doses. 

In all instances there was a decrease in the 

total leucocyte count and the percentage 

immature cells," - Excerpta med. 

of 

See 

2950 

PYRIFER 

2987 3487 3500 

2960 StÃger, R. NEUE INTERNE BEHANDLUNG VON KREBS- 

METASTASEN BEZIEHUNGSWEISE METASTAJISCHEN 

REZIDIVEN DER KREBSKRANKHEIT (VORLAUFIGE 

MITTEILUNG). [NEW INTERNAL TREATMENT FOR 

IIETASTATIC RECURRENCES OF CARCINOMA (PRELI 

MINARY REPORT).] Wien. med. Wschr., 1950, 

100: 348-352. Approx. 30 refs. Abstracted 

IÃ±T Excerpta med., Sect. 5, 1951, 4: No. 421. 

PYRIMIDINE ANALOGS 

2961 

Â«Bieber, S. ANALOGS OF NUCLEIC ACID DERIVATIVES 

AND THE GROWTH AND DEVELOPMENT OF RANA PIPIENS. 

I. THE CYCLIC INHIBITION OF THE DEVELOPMENT 

OF RANA PIPIENS. J. Cellul. Physiol., 1954, 

44: 11-31. Abstracted in: Chem. Abstr., 1955, 

4"9":2629e. 

2962 

Hitchings, G. H., Elion, G. B., Falco, E. A., 

Russell, P. B. and Vander Werft, H. STUDIES 

ON 

N. 

ANALOGS OF 

York Acad. 

PURINES AND PYRIMIDINES. 

Sc., 1950, 52: 1318-1335. 

Ann. 

36 refs. 

2963 

Barker, G. R., Dhar, M. Â».and Parsons, L. D. 

THE ACTION OF SOME PYRIMIDINE DERIVATIVES 

AND RELATED COMPOUNDS ON SARCOMA DEVELOPMENT 

IN GRAFTED MICE. Brit. J. Cancer., 1951, 5: 

124-129. 11 refs. 

2939 

PYRIMIDINES 

2964 Hitchings, G. H., Elion, G. B., VanderWerff, H. 

and Falco, E. A. PYRIMIDINE DERIVATIVES AS 

ANTAGONISTS OF PTEROYLGLUTAMIC 

Chem., 1948, 174: 765-766. 

ACID. J. Biol. 

2965 Hoshikawa, S., Handa, S., Hasegwa, A., Tateyama, 

M., Kato, M., Sasori, T., Takahashi, K. and 

Matsukawa, T. EFFECTS OF SEVERAL PYRIMIDINE 

COMPOUNDS ON THE ASCITES TUMOR CELLS; PRELI 

MINARY REPORT. Gann, Tokyo, 1954, 45; 548- 


PYRIMIDINES, 2,4-DIAMINO- 

2966 Bendich, A., Geren, W. D. and Brown, G. B. 

A STUDY OF THE METABOLISM OF 2,4-DIAMINOPY- 

RIMIDINE. J. Biol. Chem., 1950, 185: 435- 

438. 15 refs. 

2967 

Hitchings, G. H. DARAPRIM AS AN ANTAGONIST OF 

FOLIC AND FOLINIC ACIDS. Tr. R. Soc. Trop. 

M. Hyg.. Lond., 1952. 46: 467-473. Discussion: 

p. 498-508. 23 refs. ~ 

2968 

Â«Hitchings, G. H., Falco, E. A., Elion, G. B., 

Singer, S., Waring, G. B., Hutchison, D. J. 

and Burchenal, J. H. 2,4-DIAMINOPYRIMIDINES 

AS ANTAGONISTS OF FOLIC ACID 

Arch. Biochem., N. Y., 1952, 

AND 

40: 

FOLINIC ACID. 

479-481. 

2969 Murphy, M. L., Ellison, R. R., Karnofsky, D. A. 

and Burchenal, J. H. CLINICAL EFFECTS OF THE 

DICHLORO AND MONOCHLOROPHENYL ANALOGUES OF 

DiAMiNOPYRIMIDINE: ANTAGONISTS OFFOLICACID. 

J. Clin. Invest., 1954, 33: 1388-1396. 23 

refs. Abstracted in: Chem. Abstr., 1955, 49: 

1165b. 

2970 

Â«Murphy, M. L., Ellison, R. R., Karnofsky, D. A. 

and Burchenal, J. H. CLINICAL STUDIES WITH 

2,4-DIAMINO-5(3



172 

QUERCITIN 

2974 

Cruz-Coke, E., Plaza de los Reyes, H. and Oyarzun, 

O. SARCOMA FUSOCELULAR TRANSPLANTABLE DE LA 

RATA; ACCIÃ“N DE (JUERCETRINA, THIOUREA Y 

yONOYODOACETATODE SODIO EN SU DESARROLLO. 

[TRANSPLANTABLE FUSOCELLULAR SARCOMA OF RAT; 

ACTION OF QUERCITRIN, THIOUSEA AND SODIUM 

MONOIODOACETATE ON ITS DEVELOPMENT.] Bol. 

Soc. biol. Santiago, 1949, 6: 48-52. 5 refs. 

See 

2819 2820 

QUINACRINE 

see also ACRIDINE, 6-CHLORO-2-METHOXY-9-a- 

DIETHYL-AMINO- 6 - PENT YLAMINO- 

2975 

Â°â„¢tSoli> *' SAGGIÂ°DELL'AZIONE COMBINATADI 

UN PREPARATOACRIDINICO E COLCHICINA SULLA 

CRESCITA DI UN TUMORETRAPIANTASSE . [STUDY 

ON THE COMBINEDACTION OF AN ACRIDINE COM 

POUNDANDCOLCHICINE ON THE GROWTHOF A 

TRANSPLANTEDTUMOR.] Tumori, Milano 1955 

41: 123-126. 2 refs. Colchicine in doses of 

07015 mg and Italchina-Atebrin, an acridine 

derivative, in doses of 0.6 mg were given to 

50 white rats with Ehrlich carcinoma. A 

modest slackening of the growth of the tumor 

"aS observed- The survival time remained 

U975a 

Â°COIÂ°?HTr?MAaÂ¡;dn!'eCC0' A- AZIONE COMBINATA DI 

COLCHICINA E DI UN ACRIDINICO SU CULTURE DI 

FIBROBLASTI EMBRIONALI DI POLLO. [THE CoS 

BINED EFFECT OF COLCHICINE AND AN ACRIDI 

nM.^S0?SfT ATURES.] TumorÃ^lano, 

39. 161-163. 3 refs. Abstracted in: 

037 

4-QUINALDINECARBOXYLIC 

See 

2976 

ACID, 6-AMINO- 

2,4-QUINOLINEDICARBOXYLIC ACID, 1, 2, 3, 4- 

TETRAHYDRO-6-AMINO- 

2976 

Euler, H. von, Euler, B. von and Hasselquist, H. 

ENTWICKLUNGSHEMMUNG UND ENTWICKLUNGSBESCHLEUNI 

GUNG VON TUMOREN DURCH N-HALTIGE STOFFE. [TUMOR- 

INHIBITING AND CARCINOGENIC EFFECT OF NITROGEN- 

CONTAINING 

1955, 60: 

SUBSTANCES.] Zschr. Krebsforsch 

279-282. Approx. 25 refs. 

QUmONE, 

2977 

Nosek, J. and Bartek, J. LÃ‰ClVA RAKOVJNY. I. 

[DRUGS ACTIVE AGAINST CANCER. I.] Cas. 

Cesk. lÃ©k Ved. priloha, 1950, 63: 264-265. 

3 refs. "Para-benzoquinone and~~dulcit bound 

SeÂ« 

799 

mutually by a hydrogen-budge considerably 

decreases the growth of Walker's contagious 

cancer of rats, even if this compound is 

very poisonous for the body." 

QUmONE, 

p-BENZO- 

2,5-BIS-ETHYLENE-IMINO- 

2978 

Loustalot, P.. Schar, B. and Meier, R. ÃœBER 

ANTIMITOTISCHE UND 

DES INNEREN SALZES 

TUMORHEMMENDE EIGENSCHAFTEN 

DES 2,5-BIS-ATHYLENIMINE- 

HYDROCHINONS. [ANTIMITOTIC AND TUMOR-INHIBI 

TING PROPERTIES OF AN INTERNAL 

BIS-ETHYLENEMINOHYDROQUINONE.] 

SALT OF 2,5- 

Experientia, 

Basel, 1955, 11: 186-187. 8 reis. "A new 

hydroquinone compound...has a multiform antimitotic 

effect and a potent tumor inhibiting 

action on a wide spectrum of inoculated tumors 

of mice and rats." 

1, 4-QUINONE, 2, 5-BIS-ETHYLENE-IMINO-BENZO- 

2979 

Domagk, G., Petersen, S. and Gauss, W. EIN 

BEITRAG ZUR EXPERIMENTELLEN CHEMOTHERAPIE 

DER GESCHWÃœLSTE. [EXPERIMENTAL CHEMOTHERAPY 

OF 

617-622. 

TUMORS.) 

5 refs. 

Zschr. 

Comperative 

Krebsforsch., 

studies 

1954, 

oÃ¯~~ 

59: 

the inhibitory effect of TEM, nitrogen mus 

tard and 2:5-bisethylene-imino-benzo-quinone- 

1:4 on Ehrlich carcinoma and Yoshida sarcoma 

in animals. The action of the quinone 

derivative was stronger and more specifically 

directed against tumor cells. 

QUIÃ‘ONES 

2980 

Grinberg, R. and Correa Urquiza, L. M. LA 

ACCIÃ“N DE LA PARA-Y ORTOQUINONA SOBRE EL 

SARCOMA DE RATA DE ROFFO. 

PARA- AND ORTHO-QUINONE ON 

[THE ACTION 

ROFFO'S RAT 

0F 

SARCOMA.] 

1010-1013. 

Sem. med., 

25 refs. 

B. Air., 1948, 55: 

Abstracted in: " 

Excerpta med., Sect. 5, 

Chem. Abstr., 1949, 43: 

1949, 2: No. 1997; 

2323i.~ The qui 

Ã±ones had no retarding effect on the growth 

of the tumors. 

2981 

Sakai, S., Minoda, K. and Saito, G. ON THE 

ANTI-CANCER ACTION OF QUINONE DERIVATIVES 

Gann, Tokyo, 1955, 46: 59-66. 9 refs 

By testing a long series of quinone deriva 

tives for their tumorcidal action on NF 

sarcoma in vitro, and for their inhibiting 

action on Ehrlich ascites carcinoma in vivo 

it was demonstrated that certain thioquinone 

derivatives show significant anticancer 

effects. 

See 

787 1813 

QUmOXALINE 

See 

121 

R128 

see NITROGEN MUSTARDS. ANILINE p-AMINO-N-N- 

DI(CHLOROETHYL- 

R151 

see NITROGEN MUSTARDS. ETHYLAMINE fl- 

NAPTHYL-CHLORO- 

RESISTANCE STUDIES 

2982 

Hirono, I. and Yodoyama. C. DEVELOPMENT OF THE 

RESISTANCE OF TUMORS IN CHEMOTHERAPY; (STUDIES 

ON THE YOSHIDA SARCOMA). Gann, Tokyo, 1954, 

45: 496-498. In Japanese. The development 

Ã–T resistance to the nitrogen mustards, 8- 

azaguanine, and Colchicine are discussed. 

2983 

LettrÃ©, H. EIGENSCHAFTSXNDERUNGEN VON TUMOR 

ZELLEN. [CHARACTER CHANGES OF TUMOR CELLS 1 

Zschr. Krebsforsch.. 1953, 59: 568-580. 

36 refs. Abstracted in: Excerpta med.. Sect 

16, 1954, 2: No. 3462.



173 

RIBOFLAVIN 

2984 Guariscili, C. and An ich In i , C. SULL'AZIONE 

ANTITUMORALE DI ALCUNI COMPLESSI FOSFO- 

RIBOFLAVIN-METALLICI. [ANTITUMORAL ACTION 

OF VARIOUS RIBOFLAVIN PHOSPHATE-MET AL COM 

PLEXES.] Boll. Soc. ital. blol. aper., 

1954, 30: 752-755. 2 rets. 

2985 Seror, J. and Boix, A. VITAMINE B2 ET CANCER. 

[VITAMIN 

carcin., 

B2 AND CANCER.] Bull, alger, 

1953, 6: 155-161. 10 reÃs. Report 

of 2 cases of epithelioma with clinical Im 

provements following vitamin B2 therapy. 

2986 Taylor, A. and Carmichael, N. YOLK-SAC CULTI 

VATED TUMOR TISSUE AND EXPERIMENTS IN TUMOR 

CHEMOTHERAPY. Texas Rep. Biol. M., 1948, 

6: 504-512. 8 refs. "Riboflavin in varying 

Concentrations were used as the test chemical 

in a total of 11 experiments involving 231 

tumor bearing eggs. There was no appreciable 

effect on embryo or tumor size. Riboflavin 

in 5 mg doses was not toxic to 8 day chick 

embryos." 

RIBOFLAVIN 

ANALOGS 

see ISOALLOXAZINE, 6-CHLORO-9-(l'-D-SORBITYL)- 

ISOALLOXAZINE, 6, 7-DICHLORO-9(l'-D-SORBITYL) 

ISOALLOXAZINE, 6, 7-DIMETHYL-9-HYDROXYETHYL- 

RIBOFLAVIN 

DEFICIENCY 

2987 Stoerk, H. C. and Emerson, G. A. COMPLETE 

REGRESSION OF LYMPHOSARCOMAIMPLANTS FOLLOW 

ING TEMPORARY INDUCTION OF RIBOFLAVIN DE 

FICIENCY IN MICE. Proc. Soc. Exp. Biol., 


Excerpta med.7~Sect. 5, 1949, 2: No. 3545. 

RIBOFLAVIN, 

DIETHYL 

2988 Aposhian, H. and Lambooy, J. P. RETARDATION OF 

GROWTH OF WALKER RAT CARCINOMA 256 BY ADMIN 

ISTRATION OF DIETHYLRIBOFLAVIN. Proc. 

Exp. Biol., N. Y., 1951, 78: 197-199. 

Soc. 

5 refs. 

Abstracted in: Excerpta mÃ«H., Sect. 2, 1952, 

5: No. 4507. 

RICIN 

2989 Mosinger, M. LES EFFETS CLASTOGÃˆNES ET BLASTO- 

GÃˆNES EXERCÃ‰S PAR LA RICINE SUR LE SYST.ÃŠMERÃ‰- 

TICULOENDOTHÃ‰LIAL ET LES TISSUS LYMPHOIDE ET 

MYÃ‰LOÃ•DE. LEUR INTÃ‰RÃŠTTHÃ‰ORIQUE ET THÃ‰RA 

PEUTIQUE POSSIBLE EN CANCÃ‰ROLOGIE. [CLASTO- 

GENIC AND BLASTOGENIC EFFECTS OF RICIN ON THE 

RETICULOENDOTHELIAL SYSTEM AND THE LYMPHOID 

AND MYELOID TISSUES. THEORETICAL AND POSSIBLE 

THERAPEUTIC INTEREST IN CANCEROLOGY.] Bull. 

Acad. nat. med., Par., 1951, 135: 70-74. 


5: No. 1555. 

2990 

Mosinger, M. EFFETS NÃ‰CROSANTS OU CLASTIQUES 

EXERCÃ‰S PAR LA RICINE SUR DIVERS ORGANES ET 

SUR LES SARCOMES EXPERIMENTAUX. [NECROTIC 

OR CLASTIC EFFECTS EXERTED BY RICIN ON 

VARIOUS ORGANS AND ON EXPERIMENTAL SARCOMAS.] 

C. rend. Soc. biol., 1951, 145: 412-415. 

Ã•refs. 

2991 Mosinger, M. SUR LA TOXICOLOGIE DE LA RICINE 

DANS LE CADRE DE L'AGRESSOLOGIE. SES CAPACITÃ‰S 

CLASTOGÃˆNES SUR LES TISSUS NORMAUXET LE SARCOME 

EXPERIMENTAL DU RAT. EFFETS NEUROENDOCRINIENS. 

[TOXICOLOGY OF RICIN IN RELATION TO SHOCK. 

EFFECT ON NORMAL TISSUES AND EXPERIMENTAL SAR 

COMA OF THE RAT. NEUROENDOCRINE EFFECTS.] 

C. rend. Acad. sc., Par., 1951, 232: 184-186. 

2992 

Mosinger, M. TRAITEMENT DE RATS SARCOMATEUX 

PAR LA RICINE, LES NEUROPLÃ‰GIOUES ET LA SO- 

MATOTROPHINE; MASTOCYTOSE GÃ‰NÃ‰RALEET PÃ‰RI- 

TUMORALE. [TREATMENT OF SARCOMA IN RATS WITH 

RICIN, GANGLION BLOCKING AGENTS, AND SOMATO- 

TROPIN; GENERAL AND PERITUMOHAL MASTOCYTOSIS.] 

C. rend. Soc. biol., 1955, 149: 152-155. 

3 refs. 

29Solomides, J. and Ronsin, E. SUR UNE CHIMIO 

THÃ‰RAPIE DU CANCER. [CHEMOTHERAPY OF CANCER.] 

Avenir mÃ©d., Par., 1954, 51: 13-16. Abstracted 

in: Excerpta ned., Sect. TB, 1955, 3: No. 159. 

"Practical and theoretical consideration on 

the anticancerogenic effect of cod liver oil 

and ricinus oil." - Excerpta med. 

RIVANOL 

2994 Kanzaki, K. INHIBITING EFFECTS OF TRYPAFLAVIN 

AND 

J., 

RIVANOL UPON YOSHIDA SARCOMA. Tohoku M. 

1953, 47: 576-578. 2 refs. In Japanese. 

English summary. Abstracted in: Excerpta med., 

Sect. 16, 1954, 2: No. 2163. 

ROSE 

BENGAL 

2995 

Osswald, H. DER EINFLUSS FLUORESCIERENDER 

FARBSTOFFE 

[EFFECT ON 

AUF TRANSPLANTABLE TUMOREN. 

FLUORESCENT DYES ON TRANS- 

PLANTABLE TUMORS.] Zschr. Krebsforsch., 

1951, 58: 65-71. 

Abstr.T~1952, 46: 


4681h. A combination of 

salts of BengaT~Rose with trypaflavine had a 

See 

1691 

RTN 

stronger inhibitory effect on tumor growth 

than urethane with which it was compared. 

see ORGAN EXTRACTS 

SABINE 

2996 SÃ¡nchez Caballero, H. J. UN NUEVO TÃ“XICO MITO- 

TICO: LA SABINA. [A NEW MITOTIC POISON: SABINE.] 

Medicina, B. Air., 1952, 12: 82-91. 6 refs. 

Sabine is an extract from~Juniperus sabinae. 

Its effects upon the skin of rats are comparable 

to those of podophyllin. The boiling extract 

promotes tumor growth and a softening of the 

sarcoma. The extract obtained from the cold 

solution inhibits tumor growth and also softens 

the sarcoma. In the rat sabine has caryoclastic 

effects upon tumor tissue without affecting 

the normal tissue. 

SACCHAROMYCES 

see YEASTS 

SALICYLIC 

ACID 

2997 Euler, H. von, Hasselquist, H. and Jaarma, M. 

SALICYLSAURE-U. SULFONAMID-DERIVATE. II. 

[SALICYLIC ACID AND SULFONAMIDE DERIVATIVES. 

II.] Ark. Kern., Stockh., 1947, 24A: 1-12. 

19 refs. "Most of the compounds gave nega 

tive results." 

See 

3156



174 

SANAMYCIN 

see ACTINOMYCIN C 

SAPONIN 

2998 

Butros. J. THE EFFECT OF SAPONIN ON TISSUE AND 

CANCERCELLS IN VITRO. Cancer Res., 1948, 8: 

221-30. 3 pi. 9 reÃs. Slices of normal iTver 

and kidney and methylcholantbrene-induced fibro 

sarcoma were placed in a saponin solution. De 

generative changes in cells of both normal and 

pathological tissue occurred. The changes were 

pycnosis, clumping, fragmentation and breakdown 

of chromatin, nucleoli and nuclear membrane. 

No changes in cytoplasmic granules and mito 

chondria were observed. 

SARCOLYSINE 

see NITROGEN MUSTARDS. ALANINE, N-DI-(2-CHLORO- 

ETHYLJAMINOPHENYL- 

SARKOMYCIN â€”¿ EFFECT 

ON MICROORGANISMS 

2999 Takeuchi, T. BACTERIOLOGICALSTUDIES ON ACTINO- 

MYCETESPRODUCTSEXHIBITING ANTI-TUMORACTIVITY. 

II. THE BACTERIOSTATICEFFECT OF SARKOMYCIN 

AND ITS RELATION TO SULFHYDRYLGROUP. J. Anti 

biotics, ser. A, Tokyo, 1954, 7: 37-44. 7 refs. 

In English. 


3000 

Ishiyama, S., Hirayama, H., Takamura, II. and 

Ohashi, T. FURTHER OBSERVATIONS UPON THE 

CYTOSTATIC EFFECTS OF SARKOMYCIN: AN EXPERI 

MENTAL STUDY ON THE EHRLICH ASCITES CARCINOMA 

IN MICE. 

8: 57-65. 

J. Antibiotics, 

tab. 6 refs. 

ser. A, Tokyo, 1955, 

In English. Antifumor 

effects of sarkomycin were not satis 

factory when there was a delay in its use 

of more than 2 days after implantation. 

3001 

Takeuchi, T., Nitta, K., Yamamoto, T., and 

Umezawa, H. EFFECT OF SARKOMYCIN ON EX 

PERIMENTAL ANIMAL TUMORS. J. Antibiotics, 

Ser. A, Tokyo, 1955, 8:110-117. 

3002 

Â«Umezawa, H. and Ishiyama, S. ANI 1 

CANCER EFFECTIVENESS OF SARKOMYCIN. 

Chemotherapy, Japan, 1954, 2:105. 

3003 

Umezawa, H., Takeuchi, T., Nitta, K., Yamamoto, 

T. and Yaraaoka, S. ON SARKOMYCIN AND OTHER 

ACTINOMYCETES PRODUCTS EXHIBITING ANTITUMOR 

ACTIVITY. Gann, Tokyo, 1954, 45: 543-546. 

In Japanese. 

3004 

Â»Umezawa, H., Takeuchi, T., Nitta, K., Yamamoto, 

T. and Yamaoka, S. SARKOMYCIN AN ANTI-TUMOR 

SUBSTANCE PRODUCED BY STREPTOMYCES. J. 

Antibiotics, ser. A, Tokyo, 1953, 6: 101. 

3005 

Umezawa, H., Yamamoto, T., Takeuchi, T., Osato, 

T., Okami, Y., Yamaoka, S., Okuda, T., Nitta, 

K.. Yagashita, 

SARKOMYCIN, AN 

K., Utahara, R. and Umezawa, S. 

ANTI-CANCER SUBSTANCE PRODUCED 

BY STREPTOMYCES. Antibiotics, 1954, 4: 514- 

520. 11 refs. 

3006 

Yamamoto, T., Yamaoka, S., Umezawa, H., Takeuchi, 

T. and Nitta, K. ANTI-TUMOUR EFFECTS OF 

SARKOMYCIN. Gann, Tokyo, 1954. 45: 503-505. 

In Japanese. Sarkomycin administered in daily 

doses of 2.5-5 mg orally, intravenously or 

interperitoneally exhibited a tumor inhibi 

ting action in mice bearing Ehrlich carcinoma. 

See 

651 

SARKOMYCIN â€”¿ THERAPY 

3007 

Â«Ishiyama, S. CLINICAL OBSERVATIONS OF SOME 

MALIGNANT TUMORS TREATED WITH SARKOMYCIN, 

A NEW ANTI-TUMOR ANTIBIOTIC. J. Antibiotics. 

ser. A, Tokyo, 1954, 7j 82-87. 

3008 

Ishiyama, S. CLINICAL OBSERVATIONS OF SOME 

MALIGNANT TUMORS 

A NEW ANTI-TUMOR 

TREATED WITH 

ANTIBIOTIC. 

SARKOMYCIN, 

J. Antibiotics, 

Ser. A, Tokyo, 1954, 7: 82-87.. 9 refs. In 

English. Of 78 inoperable cancer patients 

treated with sarkomycin, 26 showed remarkable 

improvement. Good changes were observed in 

the histological and radiological pictures 

in some cases. 

3009 

Ishiyama, 3., Takahashi, H., Ishiyama, I., 

Shirado, S., Ida, M., Sumita, S., Izeki, 

S. and Shirasuga, Y. CLINICAL EXPERIENCES 

WITH ANTINEOPLASTIC ANTIBIOTIC SARKOMYCIN. 


SAURURUS LOUREIRII â€”¿ THERAPY 

3010 Watari, S. and Watari, H. ON A NEW ANTI-CANCER 

SUBSTANCE. Gann, Tokyo, 1952, 43: 178-180. 

In Japanese. 

SCREENING 

TESTS 

3011 Asheshov, I.N., Hall, E. A. and Flon, H. 

ACTION 


OF TEST COMPOUNDS ON BACTERIAL VIRUSES. 

Res., 1955, Suppl. 3, 57-62. 5 refs. 

3012 

Bieber, S. and Hitchings, G. H. THE DEVELOPING 

FROG EMBRYO AND GROWTH-INHIBITORS. Cancer 

Res., 1955, Suppl. 3, 80-82. 8 refs. 

3013 

Biesele, J. J. SOME NEGATIVE SCREENING RESULTS 

WITH MISCELLANEOUS COMPOUNDS IN TISSUE CULTURES 

OF SEVERAL TUMORS. Cancer 

No. 1, 1-5. 2 refs. 

Res., 1953, Suppl. 

3014 

Boyland, E. EXPERIMENTS ON THE CHEMOTHERAPY OF 


Biochem. 

6. THE EFFECT OF AROMATIC BASES. 

J., Lond., 1946, 40: 55-58. 9 refs. 

Abstracted 

No. 14265; Chen. 

in: Biol. 

Abstr., 

Abstr., 

1946, 

Bait., 

40: 41466. 

1947, 

~ 

21: 

3015 

Boyland, E. and Sargent, S. TESTS OF COMPOUNDS 

AGAINST VARIOUS TUMORS IN MICE. 

1953, Suppl. No. 1, 7-12. 


3016 

Clarke, D. A. 

1955, Suppl. 

MOUSE SARCOMA 180. Cancer Res., 

3, 14-17. 14 refs. 

Creech, H. J., Hauschka, T. S., Hankwitz, R. F., 

Jr., Littleton, B. J. and Andre, J. STUDIES 

WITH FOUR DISTINCT LINES OF THE EHRLICH ASCITES 

TUMOR FOR THE EVALUATION OF TWENTY-SEVEN PO 

TENTIAL INHIBITORS. Cancer Res., 1955, Suppl. 

3, 47-51. 10 refs. 

3018 Danieli!, J. t. THE DESIGNING OF SELECTIVE 

DRUGS. In: Ciba Foundation Symposium on 

leukaemia research, London, 1953. (Wolstenholme, 

G. E. W. and Cameron, M. P., eds.). 

Boston, Little, Brown and Co., 1954, 263- 

274. Discussion: p. 273-274. 4 refs.



175 

SCREENING TESTS (Continued) 

3018a 

Davidson, Jâ€žD. and Freeman, B. B. THE EFFECTS 

OF COMPOUNDS UPON P32 INCORPORATION INTO NU 

CLEIC ACIDS AS A TECHNIC FOR SELECTING ANTI- 

TUMOR DRUGS. Cancer Res., 1955, Suppl. 3, 

97-101. 12 refs. 

3019 

Dickinson. L. and Thompson, M. J. CHEMOTHERA- 

PEUTIC INVESTIGATIONS WITH ROUS SARCOMA VIRUS. 

Brit. J. Pharm., 1952, 7: 277-86. 10 refs. 


8771b. In this paper describing tectfniques 

for study of chemotherapeutic agents against 

Rous sarcoma virus, the results obtained with 

the various agents are reported. 

3020 

Field, J. B., Boryczka, A. and Costa, F. TESTS 

OF COMPOUNDS AGAINST SARCOMA 180 IN A SCREEN 

ING PROJECT IN MICE. 

Suppl. No. 2, 3-52. 


3021 

Freedlander, B. L. CHEMOTHERAPY STUDIES ON 

TRANSPLANTED 

1955, Suppl. 

MOUSE TUMORS. 

No. 2, 55-72. 


3022 

FÃ¼rst, A. and Cutting, W. C. TESTS OF COMPOUNDS 

AGAINST THE EHRLICH ASCITES TUMOR. Cancer Res. 

1955, Suppl. No. 2, 73-80. 

3023 Gellhorn, A., Kells, A. and Colino, M. MAMMARY 

ADENOCARCINOMA 755, GLIOMA 26, AND BROWN- 

PEARCE CARCINOMA. Cancer Res., 1955, Suppl. 

3, 38-43. 7 refs. 

Goodson, L. H., Barvick, L., Stone, R. G., 

Ibach, M. and Palmer, J. INHIBITION SCREEN 

ING DATA USING SARCOMA 180 AND ADENOCARCINOMA 

EO771. Cancer Res., 1955, Suppl. No. 2, 81- 

102. 

3025 

Greenberg, D. M., Norberg Sassenrath, E. and 

Larson, 

AGAINST 

A. M. NEGATIVE CHEMOTHERAPY DATA 

TRANSPLANTED SOLID MOUSE MAMMARY 

CARCINOMAS. Cancer Res., 1955, Suppl. No. 

2, 103-108. 

3026 

Hamer, D., Hughes, I. W., Stacey, M., Webb, M. 

and Woodhouse, D. L. EXPERIMENTS ON THE 

CHEMOTHERAPY OF CANCER; SCREENING TESTS WITH 

6 GROUPS OF ORGANIC COMPOUNDS ON IMPLANTED 

MOUSE TUMOURS! Brit. J. Cancer, 1950, 4: 

421-429. 23 refs. Abstracted in: ChernT 

Abstr., 1951, 45: 5325a. 

3026a 

Heidelberger, C. and Keller, R. A. THE EFFECTS 

OF TWENTY-NINE COMPOUNDS ON NUCLEIC ACID AND 

PROTEIN BIOSYNTHESIS IN SLICES OF FLEXNER- 

JOBLING CARCINOMA AND RAT SPLEEN. Cancer Res., 

1955, Suppl. 3, 106-112. 

3027 Hendry, J. A., Rose, F. L. and Walpole, A. L. 

CYTOTOXIC AGENTS. I. METHYLOLAMIDES WITH 

TUMOR INHIBITORY ACTIVITY. AND RELATED IN 

ACTIVE COMPOUNDS. Brit. J. Pharm., 1951, 


Abstr., 1951, 45: 8656h. "A large number of 

compounds, capable of reacting with amine 

groups, were examined for their effect on 

the growth of Walker tumor transplants in 

rats. These included representative cyanates, 

isocyanates and isocyanate genera 

tors, ethynyl compounds, nitriles, cyanamides 

and dicyandiamides, halogenopyrimidines, 

esters and 0-alkyl derivatives, bisor 

polyfunctional esters and earbamates, 

miscellaneous (hydroxymethyl) amides and 

(hydroxymethyl) derivatives. From this 

study (hydroxymethyl) compounds (I) pre 

pared by condensing HCHO with melamine, 

were found to be active if they contained 

Ãœor more equivalents of HCHO. Tris(hydroxy 

methyl) alkyl- and aryl-substituted melamines 

were highly active; the corresponding 

bis(hydroxymethyl)compounds were less active 

or inactive." - Chem. Abstr. 

3028 

Hendry, J. A., Rose, F. L. and Walpole, A. L. 

NEW CYTOTOXIC AGENTS WITH TUMOUR INHIBITORY 

ACTIVITY. I. METHODS AND RESULTS OBTAINED 

WITH SOME METHYLOLAMINES. Acta UniÃ³ internat, 

cancr., Louvain, 1951, 7: 472-476. "Monofunctional 

aminÃ© reactoFs have proved in 

active in our tests, as have linear bifunctional 

methylolamides. 

compound of the present 

The first active 

series was trimethylomelamine 

(M. 7924). Results obtained with 

other methylomelamines and allied derivatives 

are presented. Trimethylomelamine itself has 

some activity also against a transmissible 

mouse leukaemia (lymphoid) 

noma in Strong A mice, and 

a mammary carci 

dog Â«leukaemia?)." 

3029 

Hendry, J. A., Rose, F. L. and Walpole, A. L. 

NEW CYTOTOXIC AGENTS WITH TUMOUR INHIBITORY 

ACTIVITY. IV. THEORETICAL SPECULATIONS. 


7: 490-494. 

cancr.t Louvain. 1951 

3030 

Hitchings, G. H. and Elion, G. B. THE LACTO- 

BACILLUS CASEI SCREENING TEST. 

1955, Suppl. 3, 66-68. 8 refs. 


3031 

INACTIVE COMPOUNDS IN TUMOR CHEMOTHERAPY. 


of compounds 

1952, 12: 241-242. 

screened" for their 

A list 

effect on 

neoplastic growth and found inactive. 

3032 

INVESTIGATION OF DIVERSE SYSTEMS FOR CANCER 

CHEMOTHERAPY SCREENING. I. SUMMARY OF RE 

SULTS 

1955, 

AND GENERAL CORRELATIONS. 

Suppl. 3, 1-13. 


3033 

Isbldate, M., Sakurai, Y., Yoshida, T., Sato, 

H., Satoh, H. and Imamura, H. EXPERIMENTAL 

STUDIES ON CHEMOTHERAPY OF MALIGNANT GROWTH 

EMPLOYING YOSHIDA SARCOMA ANIMALS. SUMMARY 

OF NON-EFFECTIVE COMPOUNDS SO FAR TESTED. 

Gann, Tokyo, 1954, 45: 532-536. Tables are 

in English. 

3034 

Kanzaki, K. INHIBITING EFFECTS OF VARIOUS COM 

POUNDS 

CELLS. 

UPON SHALL NUMBER OF YOSHIDA SARCOMA 

Gann, Tokyo, 1952, 43: 326-328. In 

Japanese. 

3035 

Karnofsky, D. A. ASSAY OF CHEMOTHERAPEUTIC 

AGENTS 


ON THE DEVELOPING CHICK EMBRYO. 

Res., 1955, Suppl. 3, 83-85. pi. 

8 refs. 

3036 â€ž¿ ^ 

Â«KhanenfÃ ,F. S. and SinaÃ¯, A. IA. VLIIANIE 

RAZLICHNYKH KHIMICHESKIKH SOEDINENII NA 

RAZVITIE SARKOUY KROKERA U MYSHEI. [THE 

EFFECT OF VARIOUS CHEMICAL COMPOUNDS ON 

THE DEVELOPMENT OF THE CROCKER SARCOMA.] 

I'.iiil l. nauch. issi. lab. eksp. khimioter. 

Min. zdravookhr. SSSR, 1949, LI: No. 1, 

66-75. Mice with Crocker sarcoma were 

treated orally with 51 agents over a 

peroid of 10 days. Six agents: formyldl-valine, 

formyl-dl-norleucine, tetraoxybutyl-quinokealin, 

fluorhydric boric 

benzoilacetonate, aniol and imilin, in 

hibited growth of the sarcoma.



176 


3036a 

LePage, G. A. and Greenless, J. L. INCORPORATION 

OF GLYCINE-2-C14INTO ASCITES TUMOR-CELL PURINES 

AS A BIOLOGICAL TEST SYSTEM! Cancer Res., 1955, 

Suppl. 3, 102-105. 4 reÃs. 

3037 

LettrÃ©, H. EINIGE VERSUCHE MIT DEM MAUSEASCITES- 

TUMOR. [SOME EXPERIMENTS WITH THE MOUSE AS 

CITES TUMOR.] Zschr. Krebsforsch., 1950, 57: 

1-13. 16 reis. Abstracted in: Cheraâ€žAbstr., 

of 1952, the~mouse 46: 4680d. ascites In tumor discussing in relation the usefulness to 

tests for passive immunization, and for the 

study of both colchicine and oxidation reduc 

tion indicators, the authors report upon the 

action of immune serum, colchicine and 15 

dÃ©rivÃ¢tes,dyes, flavin dÃ©rivÃ¢tesand other 

compounds in relation to tumor inhibition and 

survival time. 

3038 

LettrÃ©, H. TESTS OF COMPOUNDS AGAINST THE 

EHRLICH MOUSE ASCITES TUMOR. 

1953, Suppl. No. 1, 55-58. 


3039 

LettrÃ©, H. TESTS OF COMPOUNDS AGAINST THE 

EHRLICH MOUSE ASCITES TUMOR. 

1955, Suppl. No. 2, 125-128. 


3 reÃs. 

3040 

Loefer, J. B. STUDIES WITH A LYMPHOSARCOMA, 

SARCOMA 180, 


AND LEUKEMIA 

1953, Suppl. 

P1534 IN MICE. 

No. 1, 59-63. 

3041 

Oettel, H. and Wilhelm, G. TESTS OF COMPOUNDS 

AGAINST EHRLICH ASCITES TUMOR, SARCOMA 180 

AND WALKER CARCINO-SARCOMA 256. Cancer Res., 

1955, Suppl. No. 2, 129-144. 

3042 

Patti, J. MOUSE SARCOMA 180 INHIBITION TESTS. 

Cancer Res., 1953, Suppl. No. 1, 65-67. 

3Â°Reilly, H. C. AN EVALUATION OF THE USE OF ANTI 

MICROBIAL ACTIVITY AS A SCREENING PROCEDURE 

FOR TUMOR-INHIBITING AGENTS. Cancer Res., 

1955, Suppl. 3, 63-65. 11 refs. 

3044 

Rokujo, T., Nishihara, T., Ukita, T., Iguchi, S. 

and Tsumita, A. SCREENING TEST OF THE 

CHEMICAL COMPOUNDS WHICH INHIBIT YOSHIDA 

SARCOMA. Gann, Tokyo, 1950, 41_: 91-92. 

3045 

Rokujo, T. and Nishihara, T. SCREENING TEST OF 

THE CHEMICAL COMPOUNDS AND THE TISSUE EXTRACTS 

WHICH 

1951, 

INHIBIT YOSHIDA SARCOMA. Gann, 

4Â£: 147-149. In Japanese. 

Tokyo, 

3046 Rokujo, T., Ukita, T., Tamura, T., Tsumita, A. 

and Kosaka, S. SCREENING TEST OF THE CHEMICAL 

COMPOUNDS WHICH INHIBIT THE YOSHIDA ASCITES 

SARCOMA OF RAT. Gann, Tokyo, 1949, 40: 140- 


3046a 

.arnpey,J. R. A CHART OF IN VIVO EXPERIMENTS 

WITH ANTICANCER AGENTS. Bull. Furraan Univ., 

1952, 35: 18-36. 

3047 Schabel, F. M., Jr. and Skipper, H. E. EFFECTS 

OF A SERIES OF TUMOR-INHIBITING AGENTS AND 

RELATED COMPOUNDS AGAINST A SPECTRUM OF MOUSE- 

ADAPTED VIRUSES. Cancer Res,, 1955, Suppl. 

3, 52-56. 8 refs. 

3048 

Scholler, J. THE SYNTHESIS AND PHARMACOLOGICAL 

TESTING OF ORGANIC COMPOUNDS AS POSSIBLE CAN 

CER CHEMOTHERAPEUTIC AGENTS. 93 p. Washing 

ton, 1952. (Thesis - Georgetown Univ.) pi. 

47 refs. 

3049 

Scholler, J., Philips, F. S. and Bittner, J. J. 

ASSAYS WITH FIRST- OR SECOND-GENERATION TRANS 

PLANTS OF SPONTANEOUS MAMMARY ADENOCARCINOMAS 

OF MICE. Cancer Res., 1955, Suppl. 3, 32-37 

pi. 3 refs. 

3050 

Schultz, J., Rothman, N. and Aronson, M. M. 

THE GROWTH AND MORPHOGENESIS OF DROSOPHILA 

MELANOGASTER AS CRITERIA FOR SCREENING TESTS. 

Cancer Res., 1955, Suppl. 3, 86-96. 2 pi. 

10 refs. 

3051 

Skipper, H. E. THE LABORATORY PHASE OF CANCER 

CHEMOTHERAPY. 

17-19. 

J. M. Ass. Alabama, 1952, 22: 

3052 

Skipper, H. E. TESTS OF COMPOUNDS AGAINST 

MOUSE LEUKEMIA AND 


SEVERAL SOLID TUMORS. 

Suppl. No. 1, 69-79. 

3053 

Skipper, H. E. and Thomson, J. R. EFFECTS OF 

A SERIES OF TUMOR-INHIBITING AGENTS AND RE 

LATED COMPOUNDS ON L1210 LEUKEMIA AND DRUG- 

RESISTANT LINES THEREOF. 

Suppl. 3, 44-46. 4 refs. 

Cancer Res., 1955 

3054 

Skipper, H. E. and Thomson, J. R. TEST OF 

COMPOUNDS AGAINST CERTAIN MOUSE TUMORS AND 

LEUKEMIAS. 147-177. Cancer Res., 1955, Suppl. No. 2, ' 

3055 

Skipper, H. E., Bell, M. and Chapman, J. B. 

SCREENING OF A DIVERSE SERIES OF CANDIDATE 

ANTILEUKEMIC AGENTS. Cancer, N. Y., 1951, 


A~bstr., 1951, 45: 9750e. Results were 

generally 

negaÃ®Tve. 

3056 

Skipper, H. E., Chapman, J. B. and Bell, M. 

THE ANTILEUKEMIC ACTION OF COMBINATIONS OF 

CERTAIN KNOWN ANTILEUKEMIC AGENTS. 

Res., 1951, !U: 109-112. 11 refs. 


Abstrac 

ted in: Chem. Abstr., 1951, 45: 9737h. 

3057 

Sparks, S. J., Walsh, M. E., Sebastianelli, L., 

Stevens, M., Landes, J., Halliday, S. L. and 

Oleson, J. J. CHEMOTHERAPY OF A GRANULOCYTIC 

CHLOROLEUKEMIA 

14! 753-757. 

IN THE RAT. 

13 refs. 


3058 

Stern, K. TESTS AGAINST TRANSPLANTED AND SPON 

TANEOUS TUMORS IN MICE. 

Suppl. No. 1, 79-80. 


3059 

Stock, C. [C]. and Buckley, S. M. STUDIES ON 

THE INHIBITION OF SARCOMA 180 IN MICE. Acta 


523-529. 10 refs. "Nearly 3000 compounds 

have been tested. Included have been carbamates, 

fluorenes, nitrogen mustards, ethylenimines, 

folie acid analogs, purines, pyrimidines, 

pteridines, antibiotics, and miscel 

laneous compounds. Fewer than 100 compounds 

have shown activity at tolerated doses. Of 

these, the mobt effective have been 2,4,6- 

triethylenimino-s-triazine, 3-bis (-chloroethyl) 

aminomethyl-4-methoxy-methyl-5-hydroxy- 

6-methyl pyridine dihydrochloride, and a 

number of folie acid analogs." 

3060 

Stock, C. C. and Tarnowski, G. SELECTION OF 

A TRANSPLANTABLE MOUSE MAMMARY ADENOCARCINOMA 

FOR CANCER CHEMOTHERAPY SCREENING STUDIES. 


1A: 194-198. 30 refs. 

3061 

Stock, C. C., Clarke, D. A., Philips, F. S. 

and Barclay, R. K. SARCOMA 180 INHIBITION 

SCREENING DATA. 

No. 2, 179-331. 

Cancer Res., 1955, Suppl.




3062 

Stock, C. C., Philips, F. S., Moore, A. E., 

Buckley, S. II., Clarke, D. A., Barclay, R. K. 

and Sugiura, K. SARCOMA 180 INHIBITION 

SCREENING 

91-179. 

DATA. Cancer Res., 1953, Suppl. 1, 

3063 

Stock, C. C., Sugiura, K., Dobriner, K. and 

Rhoads, C. P. STUDIES OP COMPOUNDS FOR IN 

HIBITION IN A SPECTRUM OF TUMORS. Acta UniÃ³ 

internat, cancr., Louvain, 1951, 7: 530-536. 

12 refs. Data 

ethylenimines, 

for several nitrogen mustards, 

folie acid analogs, 8-azaguanine 

and steroids are presented. 

3064 Sugiura, K. EFFECT OF VARIOUS COMPOUNDS ON THE 

EHRLICH ASCITES CARCINOMA. Cancer Res., 1953, 

13: 431-441. pi. 50 refs. 

3065 

Sugiura, K. STUDIES IN A SPECTRUM OF MOUSE 

AND RAT TUMORS. Cancer Res., 1955, Suppl. 

3, 18-27. 6 refs. 

3Â°TÃ®aÃªikaÂ«a, S., Yoshida, S, and Saruhashi, Y. 

SURVIVAL TIME OF YOSHIDA SARCOMA RATS TREATED 

WITH VARIOUS 

Tokyo, 1952, 

CHEMOTHERAPEUTIC 

43: 319-321. In 

AGENTS. Gann, 

Japanese. 

Among the compounds tested were aminopterin, 

colchicine, urethane, nitrogen mustard, HN2 

and vinylketon. 

3066 

Tarnowski, G. S. TESTS OF COMPOUNDS AGAINST 

VARIOUS MOUSE TUMORS. 

Suppl. No. 2, 333-338. 


3067 

Tarnowski, G. S. TUMOR INHIBITION STUDIES ON 

RC MAMMARY ADENOCARCINOMA. Cancer 

1955, Suppl. 3, 28-31. 3 refs. 

Res.. 

3068 

Tarnowski, G. S. and Stock, C. C. SELECTION 

OF A TRANSPLANTABLE MOUSE MAMMARY CARCINOMA 

FOR CANCER CHEMOTHERAPY SCREENING STUDIES. 


In a study aimed at~selecting a mouse mam 

mary carcinoma as a supplement to the mouse 

sarcoma 180 in a screening program, the 

tumor-retarding effects of 11 chemicals are 

reported. The tests were made at several 

dose levels upon seven mouse mammary carci 

nomas and one mouse ascites tumor, 

3069 

Turner, F. C. EXPERIMENTAL TREATMENT OF TUMORS 

IN MICE. 

339-362. 

Cancer Res., 1955, Suppl. No. 2, 

3070 

Turner, F. C. STUDIES WITH VARIOUS EXPERIMENTAL 

TUMORS. Cancer Res., 1953, Suppl. No. 1, 81- 

89. 

3071 

Vycital, R. O., Schrek, R. and Clarke, T. H. 

UNSTAINED CELL COUNTS AS A METHOD OF EVA 

LUATING CANCEROCIDAL AGENTS. J. Laborat. 

Clin. M., 1953, 42: 326-334. 

3072 

West, D. STUDIES WITH MOUSE SARCOMA 180. 

Cancer Res., 1955, Suppl. No. 2, 363. 

3072a 

Yamamoto, T. METHODS AND PROBLEMS CONNECTED 

KITH THE CHEMOTHERAPY OF CANCER! Kagaku, 

1954, 24:210-214. 22 refs. 

3073 

Yoshida, T. STUDIES ON CHEMOTHERAPY OF CANCER 

USING ASCITES TUMORS OF ANIMALS. Acta UniÃ³ 

internat, cancr., Louvain, 1955, 11: 260-273 


3074 

Â»Yoshida, T. THE YOSHIDA SARCOMA. 2. Ed. 177p. 

Tokyo, Nara Shobo, 1952. 

3075 

Yoshida, T. YOSHIDA SARCOMA; BASIC RESEARCH 

ON CHEMOTHERAPY OF CANCER. 218 p. Tokyo 

Nara Shobo, 1949. 14 pi. In Japanese. 

See particularly: Chapter 4, p. 163-209. 

Contents: 

malignant 

Opening remarks.- structure 

tumo- s .-Research on Yoshida 

of 

sar 

coma. -Effect of chemical substances on 

Yoshida sarcoma (basic research on cancer 

chemotherapy) .-Conclusions . 

3076 

Yoshida, T., Sato, H., Nagasawa, B., Atsumi, A.. 

Sato, H., Kobayashi, K. , Hosokawa, K. and 

Nakamura, K. EXPERIMENTAL STUDIES ON CHEMO 


SARCOMA. I. Gann, Tokyo, 1950, 41: 93-96. 

In English. 

See 

30 1274 1335 2750 3262 

SEMICARBAZIDES, 

See 

1745 

L-SERINE, 

THIO- 

O-DIAZOACETYL- 

3077 

Ellison, R. R., Karnofsky, D. A., Sternberg, 

S. S.. Murphy, M. L. and Burchenal, J. H. 

CLINICAL TRIALS OF O-DIAZOACETYL-L-SERINE 

(AZASERINE) IN NEOPLASTIC 

Phila., 1954, 7: 801-814. 

DISEASE. 

20 refs. 

Cancer, 

3078 

Stock, C. C., Reilly, H. C., Buckley, S. M., 

Clarke, D. A. and Rhoads, C. P. AZASERINE, 

A NEW TUMOR-INHIBITORY SUBSTANCE; STUDIES 

WITH CROCKER 

Lond., 1954, 

MOUSE SARCOMA 180. Nature, 

173: 71-72. 3 refs. 

3079 

Stock, C. C., Reilly, H. C., Buckley, S. M., 

Clarke, D. A. and Rhoads, C. P. AZASERINE, 

A TUMOR INHIBITORY ANTIBIOTIC. Acta UniÃ³ 


32 refs. "Azaserine has been parÃ¯Tcularly 

interesting because: 1) it has given better 

retardation of sarcoma 180, without toxicity, 

than any substance studied; 2) in inhibition 

tests with sarcoma 180 it shows approximately 

an 8-fold range between the maximum tolerated 

and minimum effective 

with 6-mercaptopurine 

doses; 3) in combination 

a marked potentiation 

of activity has been observed; 4) it has 

affected adversely other solid tumors and mouse 

leukemia; 5) it influences a number of biolo 

gical systems, such as 

embryo, micro-organisms 

the developing chick 

and mammals..." 

3080 

Sugiura, K. and Stock, C. C. IV. EFFECT OF 

O DI AZOACETYL-L-SERINE (AZASERINE) ON GROWTH 

OF VARIOUS MOUSE AND RAT 

Exp. Biol., N. Y., 1955, 

TUMORS. Proc. 

88: 127-129. 

Soc . 

4 refs. 

See 

1463 2886 

SERUM â€”¿ EFFECT 

see also 


TRYPANOSOMA CRUZI 

3081 

Aizawa, K. and Sakai, S. THE EFFECT OF VARIOUS 

ANIMALSERA UPON YOSHIDA SARCOMA. Gann, Tokyo, 

1954, 45: 358-361. In Japanese.



178 

SERUM â€”¿ EFFECT 

(Continued) 


3082 

Alzana, M., Imamura, T., Uotoyama, T., Kasai, 

S., Tozawa, T., Abe, H., Sasage, S. and 

Ikeda, K. ON THE IMMUNOLOGICAL THERAPY OF 

YOSHIDA SARCOMA. Gann, Tokyo, 1951, 42: 

138-140. In English. 

3083 

Baidakova, Z . L., Lezhneva, O. H. and 

RadzikhovskafÃ , R. II. VAKJSINATSIÃŒÃ€ 

PROTIV SARCOM K8YS V MYSBEI I KROLICH'EI 

KARTSINOMY BROUN-PIRS. [THE VACCINATION 

AGAINST SARCOMA IN RATS AND MICE AND AGAINST 

BROWN-PEARCE CARCINOMA IN RABBITS.] Vopr. 

onkol., 1955, 1: No. 5, 10-14. 3 refs. Sera 

obtained through the lysis of tumor cells 

lowers the occurrence oÃ transplanted tumors 

and increases the survival time in vaccinated 

animals. Of 10 rabbits vaccinated with homogenates 

of normal rabbit serum, half showed 

immunity to the ensuing cancer transplantation. 

The same results were obtained in vaccination 

against sarcoma 298. The effectiveness of 

the vaccine was manifest in a decreased num 

ber of mÃ©tastases when control and experimen 

tal animals were compared. 

3084 Burmester, B. R. THE CYTOTOXIC EFFECT OF AVIAN 

LYMPHOID TUMOR ANTISERUM. Cancer Res., 1947, 

7: 459-67. "...describes the demonstration 

of an antibody-like factor in the serum of 

lymphoid tumor immune birds and in other birds 

which have received repeated injections of 

tumor material without viable cells. The 

factor was identified by its in vitro toxic 

effect upon tumor cells and by its in vivo 

effect when injected into birds before and 

after receiving an implant of tumor cells." 

3085 Dobrokhotov, V. N. VLIIANIE PROTIVORAKOyOI 

SYVOROTKI 

OPUKHOLI. 

NA KLETOCHNOE DELENIE RAKOVOI 

[THE EFFECT OF ANTI-CANCER SERUM 

ON THE DIVISION OF TUMOR CELLS.] BÃŒÃ11. 

eksp. biol. med., 1955, 39: No. 3, 59-62. 

2 refs. The serum was oFfained by intraperitoneal 

immunization of rabbits with 

adenocarcinoma ascite cell solution. 

Four series of experiments showed a lower 

ing of the median mitotic coefficient (arrived 

at by the method of Bliakher and Dobrokhotova) 

thus proving that this serum had anti-mitotic 

effectsÂ« 

3086 Duran-Reynals, F. and King, J. W. RECIPROCAL 

EFFECTS OF NATURAL IMMUNE BODIES FROÂ« CHICKENS 

AND DUCKS ON VARIANTS OF A SARCOMA VIRUS. 

Cancer Res., 1947, 7: 21-25. Abstracted in: 

Chem. Abstr., 1947, 4U No. 3860a. 

3087 Emmrich, R., GÃtze, E. and Penitzka, G. 

OBERWACHSTUMBEEINFLUSSENDE STOFFEDES 

BLUTES.[BLOODSUBSTANCES INFLUENCING 

GROWTH]. Zschr. Krebsforsch., 1953, 59: 

191-208 25 refs. Abstracted in: Excerpta 

raed., Sect. 5, 1954, 7: No. 108. 

3088 Filatov, r>. P. 0 VLIIANII PROTIVORAKOVYKH 

IMMUNNYKHSYVOROTOK NA PROTSESS METASTA- 

ZIROVANIIA KARTSINOMY BROUN-PIRS. [ON THE 

EFFECT OF IMMUNIZING ANTI-CANCER SERA ON 

THE METASTASES OF BROWN-PEARCE CARCINOMA.] 

Biull. eksp. biol. med., 1955, 40: No. 11, 

56-60. 11 refs. Sera containing exclusive 

ly anticancer antibodies administered to 

24 female rabbits with Brown-Pearce carci 

noma, considerably inhibited mÃ©tastases. 

3089 POÂ» 

GuÃ©rin, M. LEUCÃ‰MIES SPONTANEES ET EXPÃ‰RIMEN 

TALES CHEZ LES ANIMAUX. [SPONTANEOUS AND 

EXPERIMENTAL LEUKEMIA IN ANIMALS.] Progr. 

med., Istanbul, 1948, 1: 51-66. See es 

pecially: p. 61-62. 37 refs. Abstracted in: 

Excerpta med., Sect. 5, 1949, 'Â¿\No. 1431. 

A review including a section on therapy and 

immunization of leukemia. "Immunization 

could be obtained in hens by attenuation of 

the virulence of the agent of leukaemia 

(keeping of glycerine-mixed blood for several 

months in a refrigerator; warming of the 

blood to 560(or 37O); dilution of the blood 

to 1 10,000; the best results were obtained 

by mixing the blood with formalin in a pro 

portion of 1 300(70% of the cases). The 

immunity acts not only against the virus, 

but also against the inoculation of leukaemic 

cells." 

3090 

Hauschka, T. S. IMMUNOLOGIC ASPECTS OF CANCER: 

A REVIEW. Cancer Res., 1952, 1J2: 615-633. 

220 refs. See especially, Immunologie ap 

proaches to therapy and protection against 

carcinogens: p. 625-627. 

3091 

Ishikura, H , Itakura, S . Usubuchi, I., Suzuki, 

K., Aizawa, M., Imamura, T. and Mori, S. 

ON THE INFLUENCE OF ANTI-YOSHIDA-SARCOMA-SERA 

OF HEALED RATS AND SENSITIZED RABBITS UPON 

NEUTRALIZATION, PASSIVE IMMUNITY AND THERAPY 

OF YOSHIDA SARCOMA. Gann, 

177-179. In English. 

Tokyo, 1950, 41: 

3092 Junod, J.-M. ACTION DE L'ANTIHORMONE GONADO 

TROPE SUR LA CROISSANCE CANCÃ‰REUSE. [EFFECT 

OF A GONADOTROPHIC ANTIHORMONE ON CANCER 

GROWTH.] 

191-192. 

Schweiz, med. 

Gonadotrophin 

Wschr., 1947, 77: 

(Prolan) in small 

doses, 2-10 units per day for 30 days, pro 

duced a slightly stimulating effect on 

transplanted adenocarcinoma in mice, while 

high doses of the hormone, 200 units per 

day, produced a reduction in tumor growth. 

In a second series of experiments, rabbits 

were 

very 

treated for an extended period 

high doses of the hormone. An 

with 

antihormone, 

30-40 units per cc of blood, was 

isolated 

injected 

from 

into 

the blood of the rabbits and 

tumor-bearing mice. Treated 

with 0.2 cc of antigonadotrophin serum 

twice weekly, a marked and specific inhibi 

tion of cancer growth was produced. 

3093 

Kakehashi, J. ON THE INFLUENCE OF RABBIT SERUM 

IMMUNIZED BY URINARY EXTRACT OF SARCOMA 

PATIENTS UPON YOSHIDA SARCOMA. Gann, Tokyo, 

1952, 43: 102. In Japanese. 

3094 Kidd, J. G. REGRESSION OF TRANSPLANTED LYM- 

PHOMAS INDUCED IN VIVO BY MEANS OF NORMAL 

GUINEA PIG SERUM. I. COURSE OF TRANSPLANTED 

CANCERS OF VARIOUS KINDS IN MICE AND RATS 

GIVEN GUINEA PIG SERUM, HORSE SERUM, OR RABDIT 

SERUM.. J. Exp. M., 1953, 98_: 565-582. pi. 

3095 Kidd, J. G. SUPPRESSION OF GROWTH OF BROWN- 

PEARCE TUMOR CELLS BY A SPECIFIC ANTIBODY 

WITH A CONSIDERATION OF THE NATURE OF THE 

REACTING CELL CONSTITUENT. J. Exp. M., 

1946, 83: 227-250. Approx. 50 refs. 

3Â°Kidd J G. and Todd, J. E. INHIBITORY EFFECTS 

OF'NORMALGUINEA-PIG SERUMANDIMMUNERABBIT 

SERUM ON TRANSPLANTED AKR LYMPHOMAS. Proc. 

Soc. Exp. Biol., N. Y., 1954, Ã‹6: 781-785. 

3 refs. 

3097 Maiskil, I. N. OB ESKPERJMENTAL'NYKH OBOSNO- 

VANIÃ•AKH SPETSIFICHESKOI PROFILAKTIKI 

EXPERIMENTAL FOUNDATIONS IN SPECIFIC 

RAKA. 

TUMOR 

PROPHYLAXIS.] Biull. eksp. biol. med 1954, 

37- No. 2, 58-62. A review of prophylactic 

and immunological studies conducted at the 

Institute of experimental biology in Moscow. 

Most of the work is experimental and concerns 

chiefly use of anti-cancer sera.



179 

SERUM â€”¿ EFFECT ON MALIGNANT GROWTH 

(Continued) 

3098 

Â»Maltz, M. ESTUDIOS EN EL CRECIMIENTO CELULAR. 

I. LOS EFECTOS DEL SUERO UALTZ SOBRE CICA 

TRIZACIÃ“N DE LAS HERIDAS EN LOS RATONES. 

[STUDIES ON CELLULAR GROWTH. I. THE EFFECTS 

OF MALTZ SERUM ON THE CICATRIZATION OF WOUNDS 

IN MICE.] Arch. Peruanos Pat., 1948, 22: 

171-214. 

3099 

Mori, S., Niho, M., Honda, K. and Onoe, T. ON 

THE INFLUENCE OF CURED SERUM OF YOSHIDA SAR 

COMA RAT UPON TUMOR 

1949, 40: 145-147. 

CELLS. Gann, 

In English. 

Tokyo, 

3100 

Muttini, C. L. TUMORI E SIERO DI CAVALLO NORMALE 

E STIROIDATO. [TUMORS AND SERUM OF NORMAL AND 

THYROIDECTOMIZED 

1947, 2: 3-14. 

HORSES.] 

46 reÃs. 

Neoplasie, Tor., 

3101 Ninni. M. CONTRIBUTO ALLO STUDIO DELLE LEUCO- 

LISINE. [THE LEUCOLYSINS.j Arch. se. roed., 

Tor., 1948, 86: 444-474. Approx. 70 reÃs. 


2: No. 3012. 

3102 

Nungester, W. J. and Fisher, H. THE INACTIVA- 

TION IN VIVO OF MOUSE LYMPHOSARCOMA 6C3HED 

BY ANTIBODIES PRODUCED 

SPECIES. Cancer Res., 

IN A FOREIGN HOST 

1954, 14: 284-288. 

13 refs. 

3103 

Takeda.K. STUDIES ON THE IMMUNOLOGICAL PHENO 

MENA OF YOSHIDA SARCOMA. Gann, Tokyo, 1952, 

43: 449-478. 45 refs. In English. Abstracted 

UT: Excerpta med., Sect. 16, 1954, 2: No. 1126. 

The serum of naturally healed rats from Yoshida 

sarcoma caused vacuolar degeneration in vitro, 

it agglutinated the tumor cells and acted upon 

the protein of the tumor cells. Sera of rats 

which had died from the tumor showed no acti 

vity in vitro. Sera of immunized rabbits and 

goats "showed a strong cytotoxic effect not 

only upon Yoshida sarcoma 

tissues (species specific 

but also upon 

immunity)." 

rat 

3104 

Takeda, K., Itakura, S., Ishikura, H., Usubuchi, 

I., Aizawa, M. and Okubo, S. IMMUNOLOGICAL 

THERAPY OF YOSHIDA 

1949, 40: 126-129. 

SARCOMA. Gann, Tokyo, 

In English. Immune serum 

from rÃ¤Ts and rabbits injected in various 

strains of rats bearing Yoshida sarcoma caused 

marked tumor necrosis. Cell reactions varied 

with the strain of the experimental animal. 

3105 Todd, J. E. and Kidd, J. G. TESTS FOR ISOANTI- 

BODIES ACTIVE 

â€¢¿SERUM AGAINST 

IN CONJUNCTION 

Ã–C3HED LYMPHOMA 

WITH GUINEA-PIG 

CELLS. Proc. 

Soc. Exp. Biol., N. Y., 1954, 86: 865-868. 

3106 

Yoshio, M., Motoyama, T. and Aizawa, M. STUDIES 

ON THE THERAPY OF YOSHIDA SARCOMA WITH CHEMI 

CALS AND THOSE COMBINED WITH IMMUNE SERA. 

Gann, Tokyo, 1952, 43: 250-251. In English. 

See 

3107a 3335 3344 3690 


See 

3114 


3107 

Giri, K. V. THE KARYOLYTIC FACTOR IN THE SERUM 

OF RATS INJECTED WITH COLCHICINE. Nature, 

Lond., 1950, 165: 1021. 3 refs. 

311 iÃ¢d, J. G. REGRESSION OF TRANSPLANTED LYMPHOMAS 

INDUCED IN VIVO BY MEANS OF NORMAL GUINEA PIG 

SERUM. II. STUDIES ON THE NATURE OF THE ACTIVE 

SERUM CONSTITUENT: HISTOLOGICAL MECHANISM OF 

THE REGRESSION: TESTS FOR EFFECTS OF GUINEA 

PIG SERUM ON LYMPHOMA CELLS IN VITRO: DIS 

CUSSION. J. Exp. M., 1953, 98:585-606 3pl 

18 refs. 

31O8 

Iliale, J. B. THE HEMATOLOGIC RESPONSE IN DOGS 

TO THE 

Blood, 

ADMINISTRATION OF ANTI SPLEEN SERUM. 

N. Y., 1947, 2: 175-184. 39 refs. 


310Â£ 

Curiel, J. de J., Sanchez Illades, L., Valdes 

Ã“rnelas, O. and CastaÃ±eda, A. ESTUDIOS SOBRE 

INMUNIDAD TUMORAL; NOTA PREVIA. [TUMORAL 

IMMUNITY; 

1948, 28: 

PRELIMINARY 

377-383. 

REPORT.] Medicina, Mex., 

3110 

Delouys. F. LE TRAITEMENT BIOLOGIQUE DU CANCER. 

[BIOLOGICAL TREATMENT OF CANCER.J Scalpel, 

Brux., 1953, 106: 1234-8. 5 refs. 

3111 

Ramonova-Tskhovrebova, O. D. 0 PRIMENENII MIELO- 

LEIKO- I LIMFOTSITOTOKSICHESKOÃ• SYVOROTKI PRI 

LECHENII KHRONICHESKIKH LEÃ•KOZOV. [APPLICATION 

0F MYELOLEUKO- AND LYMPHOCYTOTOXIC SERA IN THE 

TREATMENT OF CHRONIC LEUKOSES.] Ter. arkh 

Moskva, 1954, 26: No. 6, 11-20. Chronic leu 

kemia in 40 paÃ¯Tents was treated with lymphocytotoxic 

serum, urethane and embikhin. The 

serum gave best results when no previous treat 

ment had been used. The composition of the 

serum is not given, but its properties are liken- 

311 ed t0 those of the antiretlcular cytotoxic serum. 

Thomas, J. and Daniel, J. CONSIDÃ‰RATIONS NOU 

VELLES SUR LA SÃ‰ROTHÃ‰RAPIE;SÃ‰ROTHÃ‰RAPIE 

ANTI-CANCÃ‰REUSE. [NEW ASPECTS OF SEROTHERAPY' 

ANTICANCEROUS SEROTHERAPY.] Avenir mÃ©d 

Lyon, 1947, 44: 69-75. ref ' 

See 

3301 

SERUM, ANTIRETICULAR CYTOTOXIC â€”¿ EFFECT ON 

NORMAL GROWTH 

3113 

Curatolo, A. SUL SIERO CITOTOSSICO ANTIRETI- 

COLARE; AZIONE DEL SIERO CITOTOSSICO ANTI- 

RETICOLARE SUI FIBROBLASTI COLTIVATI IN 

VITRO. [ANTIRETICULAR CYTOTOXIC SERUM; 

EFFECT OF ACS ON FIBROBLASTS CULTIVATED 

IN VITRO.] Oncologia, 

222-228. 9 refs. 

Roma, 1948, 22: 

3114 Toro, I. and Aros, B. DIE WIRKUNG DES ANTI- 

RETIKULÃ„REN ZYTOTOXISCHEN SERUMS (ARCS) AUF 

DIE FUNKTION DES RETIKULOENDOTHELIALEN 

SYSTEMS (RES). [EFFECT OF ANTIRETICULAR 

CYTOTOXIC SERUM (ARCS) ON THE FUNCTION OF 

THE RETICULOENDOTHELIAL SYSTEM (RES).] Acta 

morph. hung., 1951, 1_:361-376. 18 refs. 

The anti-reticular cytotoxic serum (ARCS) 

was prepared according to Bogomolets. ARCS 

was administered subcutaneously and intra 

venously to rats in 1 cc dosage. In order 

to measure the blocking effects of ARCS 

upon the reticulo-endothelial system (RES) 

the effects of the anti-liver serum upon 

RES also were observed. ARCS caused a 27% 

blocking of the RES in the liver, enlarge 

ment of the spleen, desquamation of the sinusendothelium 

and dÃ©sintÃ©gration of mobile cells. 

The anti-liver serum inhibited epithelial 

growth in the liver tissue, but did not in 

hibit mobility of spleen macrophages. Thus, 

ARCS furthers growth of pure epithelium 

cultures while the anti-liver serum inhibits 

their growth. 


3115 â€ž¿ 

Â»Arendarevskii, L. F. VLIIANIE RAZLICHNYKH 

FAKTOROV NA ROST OPUKHOLEVYKH TKANEI VNE OR- 

GANIZMA. [THE EFFECT OF VARIOUS FACTORS ON 

THE GROWTH OF TUMOR TISSUE IN VITRO.] Uchen. 

zapis. Kiev. rent. rad. onkol. inst., 1953, 

4: 100-112. Abstracted in: RÃ©f. Zh. Biol., 

T955, No. 25029. 3500 expiants of stomach 

cancer and its mÃ©tastases in lymphatic nodes 

were treated with various substances. Glu 

cose with ascorbic acid, adrenaline and 

carbocholine caused proliferation of 

malignant cells, while anti-reticular 

the 

cyto 

toxic serum, plasmol, cholesterin and testo 

sterone inhibited the growth of the cancer 

cells.



180 

SERUM, ANTI-RETICULAR CYTOTOXIC â€”¿EFFECT 

ON TUMOR GROWTH (Continued) 

3116 

Heiman, J. and Meisel, Dâ€ž ANTIRETICULAR CYTO- 

TOXIC SERUM (ACS). I. THE EFFECT OF ACS ON 

TUMOR GROWTH IN RATS. Cancer, N. Y., 1949, 

2: 329-334. 21 reÃs. ACS did not control 

Ã®he growth of benign or malignant transplanted 

rat tumors. A relationship between the func 

tion of the connective tissue system and in 

hibition of tumor growth was not established. 

3117 

Heiman, J. and Meisel, D. ANTIRETICULAR CYTO 

TOXIC SERUM (ACS). II. THE EFFECT OF ACS 

IN MICE WITH TRANSPLANTED AND SPONTANEOUS 

MAMMARY 335-336. TUMORS. 1 rÃ©f. Cancer, "ACS didN. not Y., inhibit~the 

1949, 2: 

growth of spontaneous mammary adenocarcinoma 

or transplanted mouse sarcoma." 

3118 

Movitz, D., Saphir, 0. and Strauss, A. A. EFFECTS 

OF AN ANTIRETICULAR CYTOTOXIC 

BROWN-PEARCE CARCINOMA OF THE 

SERUM ON THE 

RABBIT. Cancer 

Res., 1949, 9: 17-26. 67 refs. Reticuloendothelial 

tissue antiserum produces definite 

effects on the degree of malignancy 

Brown-Pearce carcinoma in rabbits. 

of the 

According 

to the dose it may cause stimulation or a cytotoxic 

effect. The cytotoxic dose enhances 

malignancy; a dose one-tenth the cytotoxic 

dose, given at 7 to 10 day intervals produces 

a mild cytostimulatory effect resulting in 

tumor inhibition. 

3119 -~ - 

Runova, M. F. VLIIANIE ANTIRETIKULIARNOI TSITO- 

TOKSICHESKOI SYVOROTKI BOGOMOL'TSA NA EKSPE.Î- 

MENTAL'NYE OPUKHOLI . [EFFECT OF THE BOGOMOLETS 

ANTIRETICULAR CYTOTOXIC SERUM ON EXPERIMENTAL 

TUMORS.] BÃ•U1. eksp. biol . med., 1947, 24: 

No. 1, 17-18. In six series of tests wiÃ®Ã¯Ã¯ 58 

rats of the Krichevskii-Sinel 'nikov strain the 

ACS obtained by immunizing rabbits with spleen 

and bone marrow extracts of rats showed nega 

tive results in all but two of the rats. 

- METABOLISM (INCLUDING EFFECTS ON METABOLIC 

PROCESSES 

3120 

Cohen, A. L., Runjavac. M. and Straus, R. EFFECT 

OF ANTIRETICULAR CYTOTOXIC SERUM ON THE RES 

PIRATION OF BONE MARROW SUSPENSIONS. Texas 

Rep. Biol. II., 1947, 5J 341-346. 6 refs. 

"Antireticualr cytotoxic serum was found to 

have no effect on the respiration of marrow 

suspensions of guinea-pigs and rabbits during 

an incubation time of 22 and 44 hours res 

pectively in dilutions from 10-6 to 10Â°." 


3121 

Kavetskii, P. E. ROL' FIZIOLOGICHISKOI SISTEMY 

SOLDINITEL'NOI TKANI V PATOGENEZE RAKA. [THE 

FOLE OF THE PHYSIOLOGICAL SYSTEM OF THE CON 

NECTIVE TISSUE IN CANCER PATHOGENESIS. ] 

Med. zh., Kiev, 1947, 16: 111-119. A review 

of the literature on tue" effects of antireticular 

cytotoxic serum on cancer. Ex 

periments with tumor-bearing mice and rabbits 

showed that the serum stimulated the connective 

tissue which in turn has an oncolytic effect 

on the cancer cells. 

lanthrene. In 3 series of experiments it was 

observed that ACS inhibited the growth of 

both carcinoma and sarcoma in mice. 

THERAPY 

3123 

Abernethy, J. W., Harrell, G. T., Morris, L. M., 

Valk, H. L. and Cheek, K. M. THE EFFECT OF 

ANTI-RETICULAR CYTOTOXIC SERUM; OBSERVATIONS 

ON CASES OF HODGKIN'S DISEASE. North Carolina 

M. J., 1948, 9: 341-350. 4 refs. Abstracted 


3124 

Brounst, G. L. SUR LE SERUM ANTIRÃ‰TICULAIRE 

CYTOTOXIQUE. [ANTIRETICULAR CYTOTOXIC SERUM.1 

Rev. med. Moyen Orient, 1950, 7: 450-458. 

Four cases of cancer are reportedly treated 

but no results are given. 

3125 

Croizat, P., Lanternier, J., Morel, P. and 

Marcakis, R. ESSAIS DE THÃ‰RAPEUTIQUE PAR LE 

S. 0. H. DANS DIVERSES MALADIES ET EN PARTI 

CULIER DANS LES AFFECTIONS HÃ‰MATOLOGIQUES. 

[ORTHOBIOTIC SERUM THERAPY OF VARIOUS DISEASES 

AND IN PARTICULAR OF HEMATOLOGIC DISEASES.] 

Lyon med., 1950, 183: 225-229. S. O. H., In 

doses of 0.08-0.01, was administered to 

patients with acute leukosis. The drug, which 

is an antireticular cytotoxic serum, has no 

effect on this cancer. 

3126 

Davis, W. D., Jr. CLINICAL OBSERVATIONS IN 

PATIENTS TREATED WITH ANTI-RETICULAR CYTO 

TOXIC SERUM. Am. J. Med., 1947, 3: 123. 

Of 106 patients treated, 62 had far ad 

vanced cancer. ACS administered in sub 

cutaneous doses of 0.5 ml had a palliative 

effect. In one patient with cervical car 

cinoma symptoms disappeared following five 

courses of injections. The peripheral 

blood in a case of myeloid leukemia res 

ponded favorably to the serum. 

3127 Ga.te, J. and Vachon, R. QUE pEUT-ON ATTENDRE 

A L'HEURE ACTUELLE DE LA THERAPEUTIQUE 

TISSULAIRE ET DU SÃ‰RUM ORTHOBIOTIQUE EN 

DERMATOLOGIE. [WHAT CAN BE EXPECTED FROM 

TISSUE THERAPY AND ORTHOBIOTIC SERUM IN 

DERMATOLOGY AT THE PRESENT TIME.] Bull, 

med. Par., 1950, 64: 549-553. Complete 

failure in the treatment of malignant reti- ' 

culosis. 

3128 

Kavetskii, II.E. ANTIRETIKULÃ•ARNA TÃŸlTOTOKSICHNA 

SIROVATKA AKAD. O.O. BOGOMOL'TSÃ•A V KLINITSI 

VNUTRISHNIKH KHVOROB. [ANTI-RETICULAR CYTO 

TOXIC SERUM OF BOGOMOLETS IN THE THERAPY OF 

INTERNAL DISEASES.] Med. zh., Kiev, 1947, 16: 

484-487. The findings of anti-reticular cy 

totoxic serum therapy in various internal 

diseases, including cancer, over a period of 

6 years are reported. Cancer of the esophagus 

in 15 patients and cancer of the stomach in 

12 patients was treated with the serum. The 

tumor regressed slightly in 10 patients, and 

an overall improvement in the general condi 

tion of all the patients was observed. 

3122 Neiman, I. M. VLIÃ•ANIE TSITOTOKSICHESKOI STI- 

MULATSII FIZIOLOGICHESKOl SISTEMY SOEDINITEL'- 

NOI TKANI NA RAZVITIE ZLOKACHESTVENNYKH 

OPUKHOLEÃ•. [THE EFFECT OF CYTOTOXIC STIMU 

LATION OF THE PHYSIOLOGICAL SYSTEM OF THE 

CONNECTIVE TISSUE UPON TUMOR DEVELOPMENT.] 

Med. Zh., Kiev, 1948, 18: No. 1, 70-77. 

Anti-reticular cytotoxic^ serum was administer 

ed to mice with tumors induced by methylcho- 

3129 Moya, G. and Mallart, A. RADIOTERAPIA Y SUERO 

CITOTOXICO ANTIRETICULAR. [RADIOTHERAPY AND 

THE ANTI-RETICULAR CYTOTOXIC SERUM.] Rev. 

clin, espafi1.,1953, 49: 244-247. Review of 

the literature on the application of the 

Bogomolets serum, mainly in neoplastic diseases. 

The serum gives best results when given approxi 

mately 2 months following X-ray therapy.



181 

SERUM, ANTI-RETICULAR CYTOTOXIC â€”¿ THERAPY 

(Continued) 

3130 

Samitz, M. H. and Stritzler, C. CLINICAL USE 

OF ANTIRETICULAR CVTOTOXIC SERUM IN DERMA 

TOLOGY; PRELIMINARY REPORT. Arch. Derm. Syph., 

Chic., 1949, 59: 493-497. "Temporary remissions 

and a feeling of well-being were obtained in 

4 cases of lymphoblastoma. The only histologie 

changes noted 

lymphoblastoma 

were in one 

group." 

of the cases of the 

3131 Skapier, J. THERAPEUTIC USE OF ANTI-RETICULAR 

CYTOTOXIC SERUM (A. C. S.) IN HODGKIN'S 

DISEASE. Cancer Res., 1947, 7: 369-371. 

Anti-reticular cytotoxic serum used in 

treatment of 22 patients with Hodgkin's 

disease gave only an improvement in the 

general condition of the patients treated, 

such as increase in body weight and favorable 

changes in blood morphology. It may be a 

useful adjunct to other accepted forms of 

therapy of Hodgkin's disease. 

See 

Slesareva, A. I. DO PYTANNÃ•A PRO ZASTOSUVANNIA 

ATSS PRY RENTGENOTERAPII ZLOIAKISNIKH OPUKHIV 

ZHINOCHYKH STATEVYKH ORGANIV. [COMBINED THER 

APY WITH ANTI-RETICULAR CYTOTOXIC SERUM AND 

ROENTGEN IRRADIATION IN MALIGNANT TUMORS OF 

FEMALE GENITAL ORGANS.] Pediat. akush., ginek., 

Kiev, 1946, 8: No. 2, 20-22. 

232 518 2029 3321 

SEHUM, 

see SERUM 

SERUM, 

IMMUNE 

KR 

see TRYPANOSOMA CRUZI 

SEXOCLASINE 

see BEE BREAD (POLLEN) 

SKI 36 

see NITROGEN MUSTARDS. PROPANE DIHYDRO- 

CHLORIDE, 1,3, -BIS[BIS(i5-CHLOROETHYL)AMINO]- 

SK1424 

see NITROGEN MUSTARDS. PYRIDINE, 3-BIS(/3- 

CHLOROETHYL) AMINOMETHYL-4-METHOXYMETHYL- 

5-HYDROXY-6 METHYL- 

SK2683 

see S-TRIAZINE, 2-ETHYLENIMINO, 4,6-DIMETHOXY- 

SODIUM AZIDE 

3133 Cudkowicz, G. EVENTUALE AZIONE DI ALCUNI INI- 

BITORI DELLA CATALASI SULLA CANCEROGENESI 

CUTANEA DA 3,4-BENZOPIRENE NEL TOPO. [POS 

SIBLE ACTION OF SOME CATALASE INHIBITORS ON 

CUTANEOUS CANCERS IN MICE CAUSED WITH BENZ- 

PYRENE.] Tumori, Milano, 1954, 40: 63-67. 

13 refs. 

See 

1001 1762 

SODIUM CARBONATE 

See 

321 

SODIUM CYANATE 

see CYANATES 

SODIUM FLUORIDE 

3134 

Black, M. M. and Kleiner, I. S. THE EFFECT 

OF INHIBITORS OF INTERMEDIARY METABOLISM ON 

ADVANCED HUMAN NEOPLASIA. 

7: 717-718. An abstract. 



Chem. 

Excerpta 

Abstr., 

med., 

1948, 

Sect. 

42: 

5, 

No. 

1949, 

786"8h. 

2: No. 2002; 

3135 

Black, M. M., Kleiner, I. S. and Bolker, H. 

ENERGY MECHANISMS IN MALIGNANT TUMORS IN 

RELATION 

1947, 7: 

TO CHEMOTHERAPY. Cancer Res., 

818-826. 20 refs. Abstracted 

in: Chem. Abstr., 1949, 43: No. 303g; 

Excerpta med., Sect. 5, I9~49, 2: No. 809. 

3136 

Â«Prokof'eva, O. G. ZADERZHIVAIUSHCHEM DEISTVII 

FTORISTOGO NATRIIA NA RAZVITIE EXPERIMENTAL'NYKH 

OPUKHOLEI. [ON THE GROrfTH INHIBITING EFFECT OF 

SODIUM 

vrach. 

FLUORIDE IN EXPERIMENTAL TUMORS.] Sovet. 

shorn., 1947, No. 10, 1-6. Abstracted 

in: Sov. med. rÃ©f. obozr. onkologiia, 1949, No. 1, 

24. In 370 white mice with transplanted Ehrlich 

carcinoma and sarcoma DS-4 the transplants did 

not take when treated with sodium fluoride. 

Papillomas showed marked regression in growth 

following sodium fluoride administration. 

MÃ©tastases also was successfully prevented. 

- Trans. Sov. med. rÃ©f. obozr. onkologiia. 

SODIUM 

2973 

LACTATE 

SODIUM TmOMALATE 

See 

2485 

SODIUM THIOSULFATE 

3137 

JaffÃ©, W, G. INHIBICIÃ“N DE TUMORES EXPERIMEN 

TALES POR EL TIOSULFATO DE SODIO. [THE IN 

HIBITION OF EXPERIMENTAL TUMORS WITH SODIUM 

THIOSULFATE.] 

17: 202-209. 

Rev. PoliclÃn. Caracas, 

10 refs. 

1948, 

3138 

Paolino, W. and Cavosto, F. P. LE METABOLISME 

DE L'HYPOSULFITE DE SODIUM CHEZ LES LEUCÃ‰MIQUES. 

SON ACTION HYPERPLASIQUE ET ANTICYTOSTATIQUE. 

[THE METABOLISM OF SODIUM THIOSULPHATE IN 

LEUKEMIC PATIENTS. ITS HYPERPLASTIC ANTICYTO- 

STATIC ACTION.] Sang, Par., 1950, 21: 394-400. 

18 refs. Abstracted in: Excerpta mÃ«Ã¢".,Sect. 

5, 1951, 5: No. 1167. "The repeated intra 

venous administration of sodium thiosulphate 

in leukaemic patients appeared to inhibit cytostatic 

treatment and, in some cases, gave rise 

to a reactivation of the disease. On the other 

hand, in one case adenopathy was apparently 

reduced as a result of the administration of 

antisulphydrylic agents (mercuric cyanide). "



182 

SPLEEN EXTRACTSâ€” EFFECT ON MALIGNANT GROWTH 

see also TISSUE EXTRACTS. AF2 

3139 

Diller, I.C. and Watson, G. F. THE EFFECT OF 

AQUEOUS SPLEEN EXTRACT ON 

IN MICE. Growth, Phila., 

GROWTH OF TU1IOR CELLS 

1949, 13: 27-44. 

13 refs. Abstracted In: Excerpta med., Sect. 

5, 1950, 3: No. 3146; Biol. Abstr., Bait., 

1950, 24:T(o. 4086. 

3140 

Ferrari, S. ISTOCHEMIOTERAPIA CON MILZA DI 

CANE PRETRATTATO CON 3:4 BENZOPIRINE IN 

TOPOLINI PORTATORI DI ADENOCARCINOMA DI 

EHRLICH. [HISTOCHEMOTHERAPY WITH SPLEEN 

EXTRACTS FROM THE DOG PRETREATED 

BENZOPYRINE IN RATS WITH EHRLICH 

WITH 3:4 

ADENO- 

CARCINOHA.] Neoplasie, Tor., 1950, 4: 

3-12. 46 refs. Spleen extract from 

normal dogs administered subcutaneously 

in 0.2 cc to 8 albino rats showed limited 

antiblastic effect upon the adenocarcinoraa; 

spleen extract from dogs pretreated with 

3:4 benzopyrine, administered intramuscu 

larly in 0.2 cc to 16 rats showed con 

siderable anti-blastic effect upon the 

tumor. 

3141 Foley E. J. RETARDATION AND REGRESSION OF 

LYMPHOSARCOMA IN C3H MICE TREATED WITH ALIEN 

MOUSE SPLEEN AND A-METHOPTERIN. Proc. Soc. 

Exp. Biol., N. Y., 1952, 79: 155-158. 

Abstracted in: Excerpta mÃ«d".,Sect. 5, 

1 rÃ©f. 

1952, 

5: No. 3159. 

3142 

Hoepke, H. DIE ANTIBLASTISCHE WIRKUNG DER MILZ 

VON WALKER-TUMOR-RATTEN. [ANTIBLASTIC EFFECT 

OF THE SPLEEN OF RATS BEARING WALKER CARCI 

NOMA.] Zschr. Krebsforsch., 1952, 58: 378- 


Sect. 16, 1954, No. 576. 

3143 Pollard, M. and Bussell, R. H. AN ANTINEOPLAS- 

TIC FACTOR IN SPLEENS OF MICE PREVIOUSLY INO 

CULATED WITH METHYLCHOLANTHRENE. Proc. Soc. 


Abstracted in: Excerpta mÃ«d~.,Sect. 16, 1954, 

2: No. 4349. 

3144 Pollard, M. and Bussell, R. ROLE OF THE SPLEEN 

IN RESISTANCE TO EXPERIMENTAL TUMORS. Texas 

Rep. Biol. M., 1953, 11: 48-57. 20 refs. 

Abstracted in: Biol. Sb~str., Bait., 1955, 29: 

No. 1084. 

3145 

Valpondi, F. ISTIOCHEMIOTERAPIA DEI TUMORI DA 

IDROCARBURI CANCERIGENI NEL RATTO ALBINO CON 

ESTRATTI SPESICI DI VITELLO PRETRATTATO CON 

20: ItETILCOLANTRENE E 3:4 BENZOPIRENE. [HISTO 

CHEMOTHERAPY OF TUMORS INDUCED WITH CANCERO- 

GENIC HYDROCARBONS IN THE ALBINO RAT, WITH 

SPLEEN EXTRACTS OF THE CALF PRETREATED WITH 

20: METHYLCHOLANTHRENEAND 3:4 

Boll. Soc, med. chir. Modena, 

BENZOPYRENE. ] 

1953, 53: 207- 

215 24 refs. 

31Watson, G. F., Diller, I. C. and Ludwick, N. V. 

See 

SPLEEN EXTRACT AND TUMOR GROWTH. Science, 

1947, 106: 348. Abstracted in: Biol. Abstr., 

Bait.,~T948, 22: No. 3724. 

3291 EFFECT 3343 ON NORMAL GROWTH 

Pardon J. C., Prince, J. E. and Berning, N. 

EFFECT OF BEEF SPLEEN EXTRACT ON MITOSIS IN 

THE SMALL INTESTINE OF THE MOUSE. Cancer 

Res., 1948, 8: 531-533. 11 refs. An acqueous 

alcohol-treated extract of beef spleen inject 

ed subcutaneously over a period of 16 days 

into normal male mice significantly decreased 

the number of mitotic figures in the epithe 

lium of the crypts of LieberkUhn, indicating 

that the action of the extract is not specific 

for or limited to neoplastic cells. 

3148 

Fardon, J. C., Winger, U. A. and Prince, J. E. 

EFFECT OF HOMOLOGOUS AND HETEROLOGOUS TISSUE 

ON MITOSIS 

Proc. Soc. 

IN HETEROZYGOUS AND INBRED MICE. 

Exp. Biol., N. Y., 1949, 72: 568- 


Sect. 5, 1950, 3: No. 2509. 

See 

THERAPY 

1806 3605 

STEROIDS 

3149 Iglesias. Râ€ž,Mardones, E., Bruzzone, S., 

Fuenzalida, F. and Lipschutz, A. STEROIDE 

IN DER BEHANDLUNG DER GESCHWÃœLSTE; EXPERI 

MENTELLE GRUNDLAGEN. [STEROIDS IN THE 

TREATMENT OF TUMORS; EXPERIMENTAL BASES.] 

Zschr. Vitamin & Forsch., Wien., 1953, 5: 

203-232. Bibliography: p. 229-232. 

3150 

Â»LettrÃ©,H. SYNERGISTS OF MITOTIC POISONS, 

ESPECIALLY STEROID HORMONES AND COLCHICINE. 

In: Xllth International Congress of pure and 

applied chemistry. New York, 1951, 294. 

3151 

Lipschutz, A. L'ACTION ANTITUMORALE DES STÃ‰ROIDES. 

[ANTITUMORAL ACTION OF STEROIDS.] Experientia, 

Basel, 1946, 2: 460-461. Approx. 25 refs. 

Abstracted inT Chem. Abstr., 1947, 41: 1759d. 

This report is essentially the same as 

in: Bull. Acad. mÃ©d., Par., 1947, 131: 

the one 

229-230. 

See 

1711 2790 

STEROIDS. 

ALDOSTERONE 

3152 

Desaulles, P., Schuler, *. and Meier, R. 

VERGLEICH DER WIRKUNG DES ALDOSTERONS AUF 

DAS FREMDKÃ–RPERGRANULOM DER RATTE MIT DER 

JENIGEN VON CORTEXON, CORTICOSTERON, CORTI- 

SON UND HYDROCORTISON. [COMPARISON OF THE 

EFFECTS OF ALDOSTERONE, CORTEXONE, CORTICO 

STERONE, CORTISONE AND HYDROCORTISONE ON 

FOREIGN BODY GRANULOMAS 

perientia, Basel, 1955, 

IN RATS.] 

11: 68-70. 

Ex 

7 refs. 

"Aldosterone applied locÃ¢Tly in doses of 

50-100/Â«genhances slightly the growth of 

granulomas and in doses up to 200ûg fails 

to inhibit such growth...its action differs 

from that of 

cortexone." 

hydrocortisone, cortisone, and



183 

STEROIDS. 

ANDROGENS 

see also STEROIDS. 

3153 

TESTOSTERONE 

VLIfANIll TESTOSTERONA NA VOZNIKNOVENIE RARA I 

PREDRAKOVYKH IZMENENIÃ• MOLOCHNYKH ZHELEZ. [EX- 

PERIHENTAL RESEARCH ON THE EFFECT OF TESTO 

STERONE ON CJNCEROGENESIS AND PRECANCEROUS 

CHANGES IN THE MAMMARY GLAND.] Tr. Akad. med. 

nauk SSSR., Vopr. onkol., 1954, No. 7, 55-60. 

6 refs. Testosterone in doses of 2 mg in 2 

ml fatty solution was injected subcutaneously 

into 78 mice with transplanted Ehrlich carci 

noma and with spontaneous tumors of the mam 

mary gland. No effects were observed on 

either the tumors or the survival time. In 

another series of experiments, testosterone 

propionate in paraphin with lanolin tablets 

was fed to 116 female mice of a highly cancer 

ous A and C3NA strains. The survival time 

was 14 months as opposed to the 6 months in 

the controls. While testosterone propionate 

did not prevent cancerogenesis, tumors occurred 

about 3 times less frequently than in the con 

trols. 

3154 SetÃ¤lÃ¤,K. ON THE INFLUENCE OF ANDROGEN AND 

ESTROGEN ADMINISTRATION ON CHEMICALLY INDUCED 

ALBINO RAT SARCOMA. Ann. med. exp. biol. 

fenn., 1947, 25: 5-23. pi. 25 refs. Both 

androgen and estrogen reduce the body weight 

of the tumor-bearing animals, more so than 

in the normal rats. It is concluded that 

the two compounds have a reducing effect on 

the weight of the new growths. 

See 

737 

STEROIDS. 

See 

64 3115 

STEROIDS. 

See 

3152 

CHOLESTEROL 

3183 

STEROIDS. ANDROSTERONE, EPIDEHYDRO- 

CORTICOSTERONE- 

STEROIDS. CORTICOSTERONE, 11-DEHYDRO- 

3155 woolley, G. W. 11-DEHYDROCORTICOSTERONE ACETATE 

IN NORMAL AND TUMOR-BEARING MICE. Proc. Soc. 


"The life expectancy of mtc"e bearing transplantable 

lymphatic leukemia P1534 was in 

creased and evidence of modification of the 

local lymphatic lesion was observed. Growth 

of the tumor mass of lymphosarcoma 6C3HED 

was prevented for a short experimental period." 

STEROIDS. CORTICOSTERONE, DESOXY- 

3156 

Albano, A. and Schumacher, H. ÃœBER DIE HEMMUNG 

DER AEROBEN GLYKOLYSE VON TUMORZELLEN DURCH 

DOCA AND SALIZYLSÃ„URE. [INHIBITION OF AEROBIC 

GLYCOLYSIS OF TUMOR CELLS BY DCA AND SALICYLIC 

ACID.] Zschr. Rheumaforsch., 1953, 12: 333- 

337. "An inhibitory action of DOCA upon 

aerobic glycolysis of living tissue prepara 

tions of a benzopyrene tumor of rats have 

been observed. Salicylic acid cannot abolish 

See 

this DOCA effect. Salicylic acid in thera 

peutic dosage produced in vivo a marked in 

hibition of aerobic glycolysis of tumor cells. 

The same effect was produced by serum of rats 

which had been injected with salicylic acid." 

732 738 739 2950 

STEROIDS. CORTICOSTERONE, 17-HYDROXY- 

3157 

Sparks, L. L., Daane, T. A., Hayashida, T., 

Cole, R. D., Lyons, W. R. and Li, C. H. THE 

EFFECTS OF 

THE GROWTH 

PITUITARY AND ADRENAL HORMONES ON 

OF A TRANSPLANTED MAMMARY ADENO- 

CARCINOMA IN C3H MICE. 

8: 271-284. 19 refs. 

Cancer, Phila., 1955, 

3158 

Zachariae, L. and Asboe-Hansen, G. REGRESSION 

OF EXPERIMENTAL SKIN TUMORS IN MICE FOLLOWING 

LOCAL INJECTIONS OF 17-HYDROXYCORTICOSTERONE- 

21-ACETATE. Cancer Res., 1954, 14: 488-489. 

9 refs. 

See 

1715 3152 3175 

STEROIDS. CORTISONE â€”¿EFFECT ON MALIGNANT 

GROWTH 

3159 Antopol, W., Glaubacb, S. and Graff, S. RE 

TARDATION OF GROWTH OF IMPLANTS 

755 IN CORTISONE-INFECTED MICE. 

OF CARCINOMA 

Proc. Soc. 


Abstracted in: Excerpta med"., Sect. 16, 1955, 

3: No. 1748. "Cortisone when administered 

ffuring the first few days after transplantation 

of carcinoma 755 in C57 mice, has a profound 

inhibitory effect on growth of the tumor but 

the tumor remains viable. These effects of 

cortisone appear to be due to the change in 

the environment and to 

vessel formation about 

the 

the 

delay in new 

transplant." 

blood 

3160 Asboe-Hansen, G. AUTORADIOCRAPH1C EVIDENCE OF 

CORTISONE ACTION ON MAST CELL EXPERIMENTAL 

SKIN TUMORS. Cancer Res., 1954, 14: 94-95 

pi. 17 refs. 

3161 

Baker, B. L. and Whitaker, W. L. THE INFLUENCE 

OF ll-DEHYDRO-17-HYDROXY-CORTICOSTERONE ON 

CHEMICALLY-INDUCED CARCINOMA. Univ. Hosp. 

Bull., Ann Arb., 1949, 15: 4. 2 refs. 

Evidence suggested that a direct application 

of ll-dehydro-17-hydroxycorticosterone to 

methyl-cholanthrene induced carcinomas in 

mice caused a significant inhibition of tumor 

growth. 

3162 

Bass, A. D. and McArdle, A. H. THE INFLUENCE 

OF CORTISONE ON THE NUCLEOPROTEINS OF CERTAIN 

NORMAL AND MALIGNANT MOUSE TISSUES. J. 

Pharra. Exp. Ther., 1954, 112: 268-273. 12 


49: 1204g. 

3163 

Bloom, F. EFFECT OF CORTISONE ON MAST CELL 

TUMORS (MASTOCYTOMA) OF THE DOG. Proc. 

Exp. Biol., N. Y., 1952, 7J>: 651-654. 

Soc. 

9 refs. The compound given daily in 100 mg 

doses caused rapid regression of the tumors, 

which completely disappeared after the 9th 

day.



184 

STEROIDS. CORTISONE â€”¿ EFFECT 


ON MALIGNANT 

3164 Brodey, R. S.. McGrath, J. T. and Martin, J. E. 

PRELIMINARY OBSERVATIONS ON THE USE OF CORTI 

SONE IN CANINE MAST CELL SARCOMA. J. Am. Vet. 

M. Ass., 1953, 123: No. 920, 391-394. 3 refs. 

Hast cell sarcomas in 3 dogs regressed follow 

ing 25 mg cortisone treatment. Adrenal corti 

cal atrophy, decrease in the count of neoplastic 

mast cells also resulted. Tumor growth recarred 

when cortisone dosage was decreased or when the 

treatment ceased. 

3165 

Brzustowicz, R. J., Svien, H. J., Bennett, W. A. 

and Higgins, G. M. THE EFFECT OF CORTISONE 

ON THE GROWTH OF TRANSPLANTED EPENDYMOMAS IN 

MICE. Proc. Mayo Clin., 1951, 26: 121-128. 

12 refs. Abstracted in: Excerpta raed., Sect. 

5, 1951, 4: No. 3499; Chem. Abstr., 1952, 46: 

No. 4669e 

3166 

Burchenal, J. H., Webber, L. F. and Johnston, 

S. F. MECHANISMS OF AMETHOPTERIN RESISTANCE 

IN LEUKEMIA. II. EFFECT OF CORTISONE ON 

SENSITIVE AND RESISTANT MOUSE 

Proc. Soc. Exp. Biol., N. Y., 

LEUKEMIAS. 

1951, 78: 352- 

354. 10 refs. Abstracted in: Excerpta meda, 

Sect. 2, 1952, 5: No. 4987. 

3167 

Crabb, E. D. and Kelsall, M. A. RELATION OF 

CORTISONE-INDUCED LYMPHOPENIA TO TRANSPLANTED 

SARCOMA IN HAMSTERS. J. Nat. Cancer Inst., 

1951, 12: 91-105. 4 pi. 10 refs. Abstracted 


3168 

Fadem, R. S., Berson, S. S., Jacobson, A. S. 

and 

THE 

Straus, B. 

BONE MARROW 

THE EFFECTS OF CORTISONE ON 

IN HODGKIN'S DISEASE. Am. 

J. Clin. Path., 1951, 21; 799-813. 30 refs. 

3169 

Goldie, H., Walker, II., Jones, A. M. and Ross, 

D.E. INHIBITION OF SEROUS EXUDATION AND 

TUMOR CELL PROLIFERATION IN PERITONEAL CAVI 

TIES OF MICE GIVEN CORTISONE. Proc. Soc. 


Abstracted in: Excerpta mÃ«d~.,Sect. 16, 1955, 

3: No. 1774. 

3170 Gottschalk, R. G. and Grollman, A. THE ACTION 

OF CORTISONE AND ACTH 

TUMORS. Cancer Res., 

ON TRANSPLANTED MOUSE 

1952, 12: 651-653. 12 

refs. Abstracted in: Chem. ÃŽBstr., 1952, 46: 

11454g. 

3171 

Green, H. N. and Whiteley, J. H. CORTISONE AND 

TUMOUR GROWTH. Brit. M. J., 1952, 2; 538-540. 

5 refsY In these experiments with rats, mice 

and piyfgeons it was found that cortisone facilita*tes 

rather than retards transplanted tu 

mor growth. It is thought that this effect 

is due to its antimitotic action on antibody 

producing cells. 

3172 

Higgins, G. M. and Woods, K. A. THE INFLUENCE 

OF CORTI SONÃ‰(COMPOUND E) UPON A LYMPHOID LEU 

KEMIA INDUCED IN AKM MICE. Anat. Ree., 1950, 

106: 204. An abstract. 

3173 

Ingle, D. J. and Nezamis, J. E. EFFECT OF COR 

TISONE ACETATE UPON GROWTH OF A LYMPHOSARCOMA 

IN THE RAT. Endocrinology, 1951, 48: 484-485. 

5 refs. Abstracted in: Excerpta mÃö".,Sect. 

3, 1952, 6: No. 1347. 

3174 

Ingle, D. J., Prestrud, M. C. and Rice, K. L. 

THE EFFECT OF CORTISONE ACETATE UPON THE 

GROWTH OF THE WALKER RAT CARCINOMA AND UPON 

URINARY NON-PROTEIN NITROGEN, SODIUM, CHLO 

RIDE AND POTASSIUM. Endocrinology. 

4J3: 510-513. 13 refs. 

1950. 

3175 

Krippaehne, M. L. and Osgood, E. E. STUDIES 

OF THE INFLUENCE OF CORTISONE AND HYDROCOR 

TISONE ON HUMAN LEUKOCYTES IN CULTURE AND 

IN EOSINOPHILIC LEUKEMIA. Acta haemat., 

Basel, 1955, 13: 145-152. 

3176 

Levine, B. and Weisberger, A. S. AUGMENTATION 

OF NITROGEN MUSTARD INDUCED LEUKOPENIA BY 

CORTISONE. Proc. Soc. Exp. 

1953, 82: 580-583. 8 refs. 

Biol., N. Y., 



3177 Martinez, C., Visscher, M. B., King, J. T. and 

Bittner, J. J. INDUCTION OF NECROSIS IN 

MOUSE MAMMARY CARCINOMA BY CORTISONE. Proc. 

Soc. Exp. Biol., N. Y., 1952, 80: 81-83. 

4 refs. Abstracted in: Chem. AT>str., 1952, 

46: 8261a. 

3177a 

Meier, R., Schuler, W. and Desaulles, P. ZUR 

FRAGE DES MECHANISMUS DER HEMMUNG DES 

BINDEGEWEBSWACHSTUMS DURCH CORTISONE. [THE 

PROBLEM OF THE MECHANISM OF CONNECTIVE TIS 

SUE GROWTH INHIBITION BY CORTISONE.] Experientia, 

Basel, 1950, 6: 469-471, 8 refs. 

"Application of Cortisone" results in a 

diminution of granuloma formation...Corti 

sone was effective by local as well as by 

general application, similar concentrations 

producing the same degree of inhibition of 

connective tissue." 

3178 Ojima, A., Hjima, S., Higashimori, S., Saeki, 

S. and Midorikawa, O. EFFECTS OF THE STEROID 

HORMONES ON THE ASCITES TUMORS. 

1954, 45: 550-552. In Japanese. 

Gann, Tokyo, 

3179 Woolley, G. W. SOME EFFECTS OF CORTISONE AND 

RELATED STEROIDS ON TRANSPLANTED TUMORS OF 

THE MOUSE. Tr. N. York Acad. Se., ser. 2, 



"Evidence has been presented tn"at cortisone 

See 

acetate has activity in reducing the rate 

of lymphoid tumor growth .when given orally, 

but that it is not so effective as when 

applied by subcutaneous injection in equal 

amounts." 

112 1335 1713 1715 1893 

3187 

METABOLISM (INCLUDING EFFECTS 

PROCESSES) 

See 

1455a 3174 

ON METABOLIC 


3180 

Isotalo, A. and Teir, H. INFLUENCE OF CORTI 

SONE ON MITOSIS. II. EFFECTS OF SIMULTA 

NEOUSLY APPLIED CORTISONE AND COLCHICINE. 

Ann. med. exp. biol. fenn., 1953, 31: 301- 

304. 6 refs. "Cortisone has an aÃ±Timitotic 

effect in the epidermis but not in the 

outer orbital gland of the rat. On simul 

taneous application of cortisone and colchicine, 

cortisone decreased the colchicine 

mitotic ratio both in the epidermis and in 

the outer orbital gland."



185 

STEROIDS. 

(Continued) 

See 

CORTISONE â€”¿ SYNERGISTIC ACTION 

732 738 739 1990 

See 


3157 3177 

STEROIDS. CORTISONE, DEHYDROsee 

STEROIDS. CORTICOSTERONE, 17-HYDROXY- 

STEROIDS. 

see HORMONES. 

STEROIDS. 

ESTROGENS 

ESTROGENS 

TESTOSTERONE 

3181 US 

Begg, R. W. STERIOD HORMONES AND TUMOR-HOST 

RELATIONS. Cancer Res., 1951, 11: 406-408. 

12 reÃs. "Pellets of testosterone propionate 

reduce adrenal hypertrophy in the tumorbearing 

rat, and an extract of the adrenal 

cortex diminishes the degree of anemia. No 

effect was noted on the growth of the Walker 

256 carcinoma." 

3182 

Biesele, J. J. and Gasic, G. SEX HORMONE EFFECTS 

ON CHROMOSOME SIZE IN LEUKEMIC AND NORMAL LYM 

PHOCYTES OF C58 MICE. Cancer Res., 1947, 7: 

65-69. 15 refs. 

3183 

Foley, E. J. RETARDATION OF TUMOR GROWTH IN 

MICE BY ORAL ADMINISTRATION OF METHYL ANDRO- 

STENEDIOL AND METHYL TESTOSTERONE. Proc. Soc. 

Exp. 

"The 

Biol., 

growth 

N. Y., 1950, 75: 811-813. 5 refs. 

of sarcoma 18u"~or adenocarcinoma 

C3H-BA is markedly retarded in mice by oral 

administration of methyl androstenediol or 

methyl testosterone in doses of approximately 

100 mg./kg. daily, when treatment is started 

the day following implantation. Inhibition 

of sarcoma 37 and adenocarcinoma EO-771, under 

similar conditions, is slight and of short 

duration. No retardation of growth of 

sarcoma 180 was noted when 100 mg./kg. doses 

of the compounds were administered daily by 

subcutaneous injection." 

3184 

Kochakian, C. D. IN VITRO EFFECT OF TESTOSTER 

ONE ON RESPIRATION OF MOUSE LIVER AND MAMMARY 

TUMOR SLICES. Proc. Soc. Exp. Biol., N. Y., 

1951, 77: 666-607. 9 refs. "The oxygen con 

sumption" of liver and spontaneous mammary tu 

mor slices from female mice was initially 

slightly increased and then progressively de 

creased by increasing concentrations of added 

testosterone." 

3185 

Lemon, H. M., Wotiz, H. H. and Robitscher, T. 

METABOLISM OF TESTOSTERONE BY NEOPLASTIC 

HUMAN PROSTATE. J. Clin. Endocr. Metab., 


ExcerpÃ¯Ã¯raed., Sect. 5, 1954, 7j No. 4O8. 

3186 

Piccagli, G. INFLUENZA DEL PROPIONATO DEL TESTO 

STERONE SULLA EVOLUZIONE DEI TUMORI DA 3:4 

BENZOPIRENE NEL COLOMBO. [EFFECT OF TESTO 

STERONE PROPIONATE ON THE EVOLUTION OF TUMORS 

WITH 3:4 BENZOPYRENE IN PIDGEONS.] Neoplasie, 

Tor., 1947, 2: 151-156. 20 refs. Testo 

sterone propÃ¯bnate in small doses was injected 

into 18 pigeons. The growth of epithelial 

tumors induced by polycyclic hydrocarbons was 

increased. Testosterone propionate in large 

doses, on the contrary, inhibited slightly the 

growth of tumors. 

3187 

Â»Stoerk, H. C. GROWTH RETARDATION OF LYMPHO- 

SARCOMA IMPLANTS IN PYRIDOXINE-DEFICIENT 

RATS 

Soc. 

BY TESTOSTERONE AND CORTISONE. Proc. 

Exp. Biol., N. Y., 1950, 74: 798-800. 


10072C. 

See 

737 2957a 3115 

STILBAKHDINE â€”¿ EFFECT 


3188 

Arcidiacono, G. AZIONE DELLE DIAMIDINE, STIL â€¢¿ 

BAM IDINA E PENTAMIDINA, SULLO SVILUPPO DEI 

TUMORI SPERIMENTALI DA BENZOPIRENE NEI 

[EFFECT OF DIAMIDINE, STILBAIIIDINE AND 

RATTI. 

PENTA- 

MIDINE UPON THE DEVELOPMENT OF EXPERIMENTAL 

TUMORS CAUSED BY BENZPYRENE IN RATS.] 

Neoplasie, Tor., 1950, 4_: 225-232, 9 refs. 

"Stilbamidine and pentamidine injected into 

rats caused pronounced tumor regression. 

The weight of the tumor after Stilbamidine 

administration decreased to 55 gr. after 

pentamidine to 34 gr. while the control 

animals had tumors weighing 82 gr. The de 

crease is attributed to hemorrhagic necrosis 

and proliferation 

of the supporting 

of the connective 

stroma." 

tissue 


PROCESSES) 

3189 Bennett, E L., Pack, D. E., Krueckel, B. J. 

and Weaver, J. C. DISTRIBUTION OF 

MIDINE IN THE LIVERS OF NORMAL AND 

STILBA 

SARCOMA- 

BEARING MICE. Cancer Res., 1953, 13: 30-38. 

28 refs. 

3*Gemmill, C. L. INHIBITORY EFFECT OF STILBAMIDINE, 

GUANIDINE AND ARGININE ON GLYCOLYSIS. Fed. 

Proc., Bait., 1948, 7_: 221. 

3191 

Hampton, J. W. F. THE EXCRETION OF STILBAMI 

DINE AND SOME RELATED COMPOUNDS IN EXPERIMENTAL 

ANIMALS. 

1947, 41: 

Ann. Trop. M. Parasit., Liverp., 

226-233. 15 refs. Abstracted in- 

Chem. ATistr., 1948, 42: 6457e. 

3192 

Reid, 

AND 

J. C. and 

EXCRETION 

Weaver, J. C. THE 

OF STILBAMIDINE-C14 

DISTRIBUTION 

IN MICE. 


3193 

Saltzman, A., Tang. Z. T., Lieben, F. and 

Snapper, I. URINARY EXCRETION OF STILBAMIDINE 

AND 2-HYDROXYSTILBAMIDINE. J. Mount Sinai Hosp., 

N. York, 1950, 17: 21-25. 13 refs. 

3194 

Snapper, I., Lieben, F., Greenspan, E. and 

Schneid, B. DETERMINATION 

AND 2-HYDROXYSTILBAMIDINE 

OF STILBAMIDINE 

DEPOSITED IN 

PARENCHYMATOUS ORGANS AND TUMORS. Cancer, 

N. Y., 1951, 4: 1246-1249. 5 refs. 

3195 Weaver, J. C., Tolbert, B. M. and Krueckel, 

B. J. INFLUENCE OF TUMORS ON LIVER CONCEN 

TRATION OF RADIOACTIVE STILBAMIDINE. Proc. 

Soc. Exp. Biol., N. T., 1950, 7j5: 741-743. 

See 

217



186 

STILBAMIDINE- PHARMACOLOGICAL AND 

PHYSIOLOGICAL EFFECTS 

3196 

Aral, H. and Snapper, I. THE INFLUENCE OF STIL- 

BAHIDINE UPON KIDNEY FUNCTION, LIVER FUNCTION, 

AND PERIPHERAL BLOOD IN MULTIPLE MYELOMA; 

NEUROLOGIC SEQUELAE OF STILBAMIDINE THERAPY. 

N. York State J. H., 1947, 47: 1867-1874. 

18 refs. 

3197 

Bierman, H. H, and Sokolow, II. CARDIOVASCULAR 

EFFECTS PRODUCED BY STILBAMIDINE IN PATIENTS 

WITH MULTIPLE MYELOMA. J. Nat. Cancer Inst., 

1949, 10: 279-289. 3 pi. 

3198 

Kannerstein, M. MORPHOLOGIC EFFECTS OF STIL 

BAMIDINE. REPORT OF AUTOPSIES IN THREE STIL- 

HAMID INE-TREATED CASES. J. Mount Sinai 

Hosp., N. York, 1949, 1Â£: 47-53. 24 refs. 

3199 

Sandkuhler, S. DAS VERHALTEN DER BLUTPHAGOCYTEN 

UNTER CHEMOTHERAPEUTISCHEN KUREN. [EFFECT OF 

CHEMOTHERAPEUTIC AGENTS ON PHAGOCYTES OF THE 

BLOOD.] Sang, Par., 1950, 21: 400-404. English 

summary. Abstracted in: Chen. Abstr., 1950, 44: 

8544g. 

3200 

Â»Snapper, I. and Schneid, B. THE DEVELOPMENT 

OF BASOPHILIC INCLUSION BODIES IN MYELOMA 

CELLS AFTER STILBAMIDINE TREATMENT. Ann. 

Int. M., 1947, 27: 541-547. 

3201 Snapper, I. and Schneid, B. ON THE INFLUENCE 

OF STILBAMIDINE UPON MYELOMA CELLS. Blood, 

Bait., 1946, 1: 534-536. 3 refs. 

3202 

Snapper, I., Schneid, B. and Kurnick, N. THE 

PRESENCE OF DIAMIDINES IN MYELOMA CELLS AFTER 

TREATMENT WITH STILBAMIDINE AND 2-HYDROXYSTIL- 

BAMIDINE. Acta Haemat., Basel, 1950, 3: 129- 

134. Abstracted in: Chem. Abstr., 1951, 45: 

10374. 

3203 Snapper, I., Schneid, B., Lieben, F., Gerber, 

I. and Greenspan, E. INFLUENCE OF NUCLEIC 

ACID UPON THE FLUORESCENCE OF NUCLEI AND 

CYTOPLASM AFTER INJECTION OF AROMATIC DIAMI 

DINES. J. Laborat. Clin. M., 1951, 3J7: 


ned., Sect. 2, 1951, 4: No. 6481; Chem. 

Abstr., 1951, 45: 629Od. 

"snapper, I., Mirsky, A. E., Ris, H., Schneid, 

B. and Rosenthal, M. DEVELOPMENT OF INCLUSION 

BODIES CONTAINING RIBOSE NUCLEIC ACID IN MYE 

LOMA CELLS AFTER INJECTIONS OF STILBAMIDINE; 

DETERMINATION OF STILBAMIDINE IN MYELOMA TIS 

SUE. Blood, Bait., 1947, 2: 311-322. 21 refs. 



Ko. 9007. 

3205 Wenzel, E. BEER SERUMEIWEISSVERANDERUNGEN BEI 

EINEM PLASMOZYTOMUNTER STILBAMIDINBEHANDLUNG. 

[SERUM PROTEIN CHANGES IN PATIENT WITH PLASMO- 

CYTOMA DURING TREATMENT WITH STILBAMIDINE.] 

Zschr. ges. inn. Med., 1952, 7: 141-144. 

14 refs. 

See 

923 3206 3218 

THERAPY 

3206 

Baker, R. L. and Casterline, R. L. MULTIPLE 

MYELOMA. A REPORT OF EXPERIENCE WITH STIL 

BAMIDINE. Am. J. M. Se., 1948, 216: 183-7. 

5 refs. Four patients were treated". The 

progress of the disease was not checked nor 

did the drug give relief from pain. Basophilic 

cytoplasmic granules appeared in the 

myeloma cells following treatment. 

3207 

Baserga, A. STILBAMIDINA E LA PENTAMIDINA 

NEL TRATTAMENTO DEL MIELOMA MULTIPLO. [STIL- 

BAMADINE AND PENTAMIDINE IN THE TREATMENT OF 

MULTIPLE MYELOMA.] Farmaco, 

2: 223-224. 10 refs. 

Pavia, 1947, 

3208 

Brewer, A. E. MULTIPLE MYELOMA TREATED WITH 

STILBAMIDINE AND PENTAMIDINE. Brit. M. 

1948, 2: 978-982. 16 refs. Four cases 

J. 

were 

fatal and two made some clinical recovery. 

Relief from pain is the outstanding feature 

of treatment with stilbamidine. The ab 

normal features of cells resulting from treat 

ment are described. 

3209 

Dubois-FerriÃ¨re, H. LA THÃ‰RAPEUTIQUE DU MYÃ‰LOME 

MULTIPLE; LE PHOSPHORE RADIOACTIF, 

MIDINE, L'URÃ‹THANE. [TREATMENT OF 

LA STILBA 

MULTIPLE 

MYELOMA; RADIOACTIVE PHOSPHORUS, STILBAMIDINE, 

URETHANE.] Praxis, Bern, 1948, 37: 42-44. 

20 refs. 

3210 

Haedicke, T. A. and Greenspan. E. M. MASSIVE 

STILBAMIDINE THERAPY OF MULTIPLE MYELOMA: 

REPORT OF A CASE. Am. J. Clin. Path., 1949, 

634-638. Abstracted in: Biol. Abstr., Bait., 

1950, 24: No. 4098; Chem. Abstr., 1949, 43: 

7571g. 

3211 

Heilmeyer, L. NEUERE BEOBACHTUNGEN AN MYELOM- 

KRANKEN MIT BESONDERER BERÃœCKSICHTIGUNG DER 

BEHANDLUNG MIT STILBAMIDIN UND PENTAMIDIN. 

[NEW STUDIES ON MYELOMA WITH SPECIAL REGARD 

TO THEIR TREATMENT WITH STILBAMIDINE AND 

PENTAMIDINE]. 

79: 837-838. 

Schweiz, med. 

Discussion: p. 

Wschr., 1949, 

838. Ten patients 

with myeloma were given total doses of 1.4 g 

of pentamidinedOO 

and total doses of 

mg daily) intravenously 

1.5-4.5 g of stilbamidine 

(50-150 mg daily). The sedimentation rate 

dropped from 162 to 84, in the first case and 

from 127 to 25 and from 80 to 2 in the second 

and third cases. At the same time there was 

increase of the hemoglobin and reduction of 

plasma cells in the marrow, as well as marked 

subjective improvements. The author considers 

this the treatment of choice. 

3212 

Jaeger, E. ZUR DIAMIDINTHERAPIE DES GENERALI 

SIERTEN PLASMOCYTOMS. [DIAMIDINE THERAPY 

OF GENERALIZED PLASMOCYTOMA.] 

1950, 4: 858-859. 8 refs. 

Med. Mschr., 

3213 

Markham, J. D., Kriz, J. R. and Williams, J. P. 

INFLUENCE OF STILBAMIDINE IN MULTIPLE MYELOMA 

WITH PRE-EXISTING RENAL INVOLVEMENT; CASE 

REPORTS. Virginia M. Month., 1949, 76: 347- 

355. 14 refs. 

3214 

Propp, S., Gorham, L. W, and Kantor, S. RECENT 

STUDIES OF MULTIPLE MYELOMA: STERNAL AND RIB 

PUNCTURE AND THE RESULTS OF TREATMENT 

STILBAMIDINE. Blood, Bait., 1949, 4: 

WITH 

36-53. 

17 refs.



STILBAMIDINE 


(Continued) 

3215 

Reich, C. and Brodsky, A. E. COEXISTING MULTI 

PLE MYELOMA AND FACET'S DISEASE OF BONE 

TREATED WITH STILBAMIDINE. J. Bone Surg., 

1948, 30A: 642-646. 12 refs. 

3216 

Snapper, I. ON THE INFLUENCE OF STILBAMIDINE 

UPON MULTIPLE MYELOMA. J. Mount Sinai Hosp. 

N. York, 1946, 13J 119-127. 

3217 

Snapper. I. STILBAMIDINE AND PENTAMIDINE IN 

MULTIPLE MYELOMA. J. Am. M. Ass., 1947, 

133: 157-161. 11 refs. 

3218 

Snapper, I. TREATMENT OF MULTIPLE MYELOMA 

WITH "STILBAMIDINE;" CLINICAL RESULTS AND 

MORPHOLOGICAL CHANGES. J. Am. M. Ass., 

1948, 137: 513-516. 7 refs. 

3219 

STILBAMIDINE IN MULTIPLE MYELONA. [SIC] 

Am. Profes. Pharm., 1948, 14: 705. 8 refs. 

3220 

Tomek, S. ZUR STILBAMIDINTHERAPIE DES PLASMA- 

ZYTOMS. [THERAPY OF PLASMACYTOMA WITH STIL 

BAMIDINE.) Wien. klin. 

892-895. 34 refs. 

Wschr,, 1951, 63: 

3221 

Zinsli, P. BEHANDLUNG DES MULTIPLEN MYELOMS 

MIT STILBAMIDIN. [TREATMENT OF MULTIPLE 

Ther' Umschau. 

223 

2259 

499 

2313 

551 1099 2014 

TOXICITY 

3222 

Collard, P. and Nevin, S. AFFECTION OF THE 

TRIGEMINAL NERVE NUCLEUS AND CENTRAL GREY 

MATTER OF THE SPINAL CORD FOLLOWING THE 

ADMINISTRATION OF STILBAMIDINE. Proc. R. 

Soc. M., Lond., 1946, 40: 87-88. 19 refs. 

3223 

Seager, L. D. and Castelnuovo, G. TOXICITY 

OF "STILBAMIDINE"; A STUDY OF THE EFFECTS 

OF CHRONIC INTOXICATION. Arch. Path. Chic., 

1947, 44: 287-296. 2 pi. Approx. 22 refs. 

3224 

Videbaek, A. STILBAMIDINBEHANDLING AF MYELO- 

MATOSE. [STILBAMIDINE IN MYELOMATOSIS.] 

Nord, med., 1949, 4: 315-316. 7 refs. 

Treatment with stiTbamidine caused severe 

pain in the area of the fifth cranial nerve 

in two cases of myeloma. 

STILBAMIDINE, 2-HYDROXY- 

3225 

Snapper, I. INFLUENCE OF 2-HYDROXYSTILBAMIDINE 

ON THE COURSE OF MULTIPLE MYELOMA. J. Mount 

Sinai Hosp., N. York, 1948, 15: 156-163. 


2, 1949, 2: No. 5532. 

See 

3193 3194 

STILBENES 

3202 

3226 

Feinstein, R. N. EFFECTS OF A GROWTH INHIBI 

TOR AND OTHER FACTORS ON THE TISSUE CATHEP- 

SINS OF TUMOR-BEARING RATS. Cancer Res., 


Chem. Xostr., 1950, 44: No. 10897e. 

3227 

Green, J. w. Jr., and Lushbaugh, C C HISTO- 

PATHOLOGIC STUDY OF THE MODE 0? INHIBITION OF 

CELLULAR PROLIFERATION; EFFECT OF 4-DIMETHYL- 

AMINOSTILBENE ON THE GROWTH OF WALKER RAT 

CARCINOMA. Cancer Res., 1949, 9: 692-700. 

20 refs. Abstracted in: ExcerpTa med 

Sect. 5, 1950, 3: No. 3878. 

3228 

Loos, D. THERAPIEVERSUCHE MIT EINEM STILBEN- 

DERIVAT BEI PLASMOZYTOM; BERICHT ÃœBER 3 

FALLE. [THERAPEUTIC ATTEMPTS WITH A STIL- 

BENE DERIVATIVE IN PLASMOCYTOMA; REPORT OF 

THREE CASES.] Zschr. ges. inn. Med., 1955 

15: 70-79. 5 refs. 

3229 

Lorenzoni, L. and Vescovo, R. AZIONE DEL 4,4'- 

DIOSSI-Â«.- Â«-'-DIETILSTILBENE SÃœLL'ADENOCARCI- 

NOMA MAMMARIO DI WALKER DEL 'MUS RATTUS ALBINUS'. 

[THE EFFECT OF 4:4'-DIOXY-* ,



188 

SUCCINIMIDE 

See 

1812 

SUGARS, 

ÃŸ- 

3232 Cappelli, L. I PRIMI RISULTATI OTTENUTI MEDIANTE 

COMBINAZIONI ZUCCHERINE BETA SUI TESSUTI NOR 

MALI E NEOPLASTICI. [THE FIRST RESULTS OBTAINED 

WITH COMBINED BETA SUGARS ON NORMAL AND NEO- 

PLASTIC TISSUES.] Policlinico, 1949, 56: 1481- 

1488. 

SULFABUTIN 

see BUTANE, 1, 4-DIMETHANESULFONYLOXY 

SULFANILAMIDE 

see also SULFONAMDES 

AND DERIVATIVES 

32Chernov V. A. and Filitis, L. N. K OTSENKE 

DANNÃ•KHKHIMIOTERAPEVTICHESKOGO EKSPERIMENTA 

V ONKOLOGII. [EVALUATING CHEMOTHERAPEUTIC 

EXPERIMENTATION IN ONCOLOGY.] Vopr. onkol., 

1955, l: No. 3, 63-71. 4 reÃs. Red streptocide~inhibited 

both M-l sarcoma and growth 

of normal rats. 

3234 Vermel' E. M. O VLIIANII SUL'FANILAMIDA I EGO 

PROIZVODNYKH NA ROST ZLOKACHESTVENNYKH OPUKHO- 

LEÃ• [THE EFFECT OF SULFANILAMIDE AND ITS 

DERIVATIVES UPON THE GROWTH OF MALIGNANT TU 

MORS.] BÃŒÃ1.eksp. biol. med., 1947, 24: 

No. 2, 133-137. Abstracted in: Chem. Abstr., 

1949 45: 9252e. Boyland's theory that 

sulfanTTamides inhibit tumor growth was tested 

by using pyrol-blue 

mice. Results were 

and rosaniline on cancerous 

negative. Ftalazol(paraphtalilsulfanilamido-thiazole) 

disulfane 

(sulfanilsulfanilaroide), white streptocide, 

sulfazole (sulfanilamino-4-methylthiazole) 

and paraaminobenzoic acid also were tested. 

Findings indicated that all these compounds 

did not inhibit but rather stimulated tumor 

growth. It is deduced that sulfanilamides, 

especially PABA are needed by a tumor in its 

growth. 

SULFAPYRIDINE 

See 

240 

SULFASUXIDINE 

See 

1441 1651 

SULFATHIAZOLE 

32fzczeklik, E. ODCZYN KRWINEK BIALYCH W PRZYPAD- 

KACH NOWOTWORÃ“W PO STOSAWANIU SULFATIAZOLU. 

[THE REACTION OF LEUCOCYTES TO SULFATHIAZOLE 

IN CANCER PATIENTS.] Polski tygod. lek., 1954, 

9- No. 25, 769-772. To 60 patients with neoplastic 

diseases sulfathiazol in daily doses 

ol 4-6 g was administered intravenously. The 

drug showed no effect on the leucocytes in 

the peripheral blood picture, but it did in 

crease the neutrophils. In 60 patients with 

various infectious diseases, sulfathiazole, 

speeded up recovery. 

SULFATHIAZOLE, 

SUCCINYLsee 

SULFASUXIDINE 

SULFHYDRYL 

COMPOUNDS 

Brunschwig, A., Arnold, J. and Edgcomb, J. 

STIMULATION AND RETARDATION OF NEOPLASTIC 

GROWTH BY SULFHYDRYL COMPOUNDS. Cancer Res., 

1946, 6: 560-562. 6 refs. 

SULFIDE, 

BIS(2-CHLOROETHYL)- 

3237 Justin-Besancon, L., Lamotte Barillon, S. and 

Polonovski, C. INTRODUCTION BIOLOGIQUE A 

L



189 

SULFIDE, BIS (2-CHLOROETHYL)..,â€” EFFECT 

ON NORMAL GROWTH (Continued) 

3243 Haussen, O. E. LE RAPPORT ENTRE L'ACTION DIRECTE 

ET L'ACTION INDIRECTE DANS LES LÃ‰SIONS LOCALES 

CAUSÃ‰ES PAR L'YPÃ‰RITE. [THE RELATION BETWEEN 

THE DIRECT AND INDIRECT EFFECT OF MUSTARD GAS 

IN LOCAL LESIONS.] Acta path, microb. scand., 

1951, Suppl. 91: 48-50. 7 reÃs. "With the 

highest conceÃ¯Ã¯Ã¯ration of mustard gas, which pro 

duced epithelial regeneration in the implants, 

no sign of regeneration Â«as observed in situ... 

This demonstrates the importance of environment 

and calls attention to the importance of the 

vessels." 

3244 Heusghem, C. and Charlier, R. ACTION DE 

L'YPÃ‰RITE AU SOUÃ‡RE ET DE L'YPERITE A 

L'AZOTE SUR LES ELEMENTS FIGURES DU SANG 

ET SUR L'Ã‰LIMINATION RENALE DES 17-CETO- 

STÃ‰ROÃ•DESSURRÃ‰NALIENS CHEZ LE CHIEN. 

[ACTION 0F DICHLOROETHYL SULFIDE AND 

CHLOROETHYLAMINE ON THE FORMED ELEMENTS 

OF THE BLOOD AND ON RENAL EXCRETION 0F 

ADRENAL 17-KETOSTEROIDS IN DOG.] Rev. 

belge path., 1949, 19: 339-345. 6 refs. 


3245 Hughes, A. F. W. and Fell, H. B. STUDIES ON 

ABNORMAL 

CULTURES 

MITOSIS INDUCED IN CHICK TISSUE 

BY MUSTARD GAS (Â¿Â¿'-DICHLORDIETHYL 

SULPHIDE). Q. J. Micr. Sc., Lond., 1949, 

9J): 37-55. 3 pi. 35 refs. 

32MÃŒrshak, A. EFFECT OF MUSTARD GAS ON MITOSIS 

AND P32 UPTAKE IN REGENERATING LIVER. Proc. 

Soc. Exp. Biol.. N. Y., 1946, 63: 118-120. 

Abstracted in: Chem. Abstr., 1957, 41: 526h. 

See 

787EFFECTS, 1935 COUNTERACTION 1942 2102 TO 2604 

3247 Bass, A. D. and Freeman, M. L. H. EFFECT OF 

FOLIC ACID AND BIS(^ -CHLOROETHYL) SULFIDE 

(MUSTARD GAS) ON TRANSPLANTED MOUSE LYMPHOSAR- 

COMA. Proc. Soc. Exp. Biol., N. Y., 1947, 

66: 523-525. 3 refs. Abstracted in: Biol. 

Ã„Fstr., Bait., 1948, 22: No. 20946. In C3H 

mice, "Synthetic folie acid," "Folvite" or 

"Teropterin" did not produce regression in 

transplanted 6 CsHED tumors. Synthetic 

folie acid partially inhibited the effect of 

bis (/*-chloroethyl) sulfide on lymphosareoma 

6 C3HED. 

3251 


PROCESSES) 

3248 

Berenblum, I. and Schoental, R. ACTION OF MUS 

TARD GAS (BB'-DICHLORODIETHYLSULPHIDE) 

NUCLEOPROTEINS. Nature, Lond., 1947, 

ON 

159: 

727-729. 15 refs. 

32Hartwell, 3. L. REACTIONS OF BIS(2-CHLOROETHYL) 

SULFIDE (MUSTARD GAS) AND SOME OF ITS DERIVA 

TIVES WITH PROTEINS AND AMINO ACIDS. J. Nat. 


32HerriOtt, R. M. INACTIVATION OF VIRUSES AND 

CELLS BY MUSTARD GAS. J. Gen. Physiol., 

1948, 32: 221-239. 53 refs. "It is shown 

that viruses containing desoxyribosenucleic 

acid are more rapidly inactivated than those 

containing only ribosenucleic acid." 

3251 

Herriott, R. M. NUCLEIC ACID SYNTHESIS IN MUS 

TARD GAS-TREATED E. COLI B. J. Gen. Physiol., 

1951, 3Â£: 761-764. 11 refs. 

32Herrmann, H. and Hickman, F. H. THE EFFECT OF 

MUSTARD ON SOME METABOLIC PROCESSES IN THE 

CORNEA. Bull. Johns Hopkins Hosp., 1948, 

82: 251-259. 3 refs. 

3253 

Northrop, J. H., Kunitz, M. and Herriott, R. M. 

REACTION OF ENZYMES AND PROTEINS WITH MUSTARD 

GAS [BlS(/3 -CHLOROETHYL) SULFIDE]. In: 

Crystalline Enzymes (Northrop, J. H.) 2. ed., 

N. Y., Columbia Univ. Press, 1948, 209-221. 

3254 

Thompson, R. H. S. THE ACTION OF CHEMICAL 

VESICANTS ON CHOLINESTERASE. 

Lond., 1947, 105: 370-381. 

J. Physiol., 

3255 

Young, E. G. and Campbell, R. B. THE REACTION 

Qt Â¿3 ,a '-DICHLORODIETHYL SULFIDE WITH PRO 

TEINS. CaÃ±ad. J. Res., 1947, 25B: 37-48. 

See 

2188 MODE OF 2189 ACTION 3244 3246 

3255a 

Butler, J. A., Conway, B. E., Gilbert, L. and 

Smith, K, A. CHEMICAL ANALOGIES IN THE ACTION 

OF IONIZING RADIATIONS AND OF RADIOMIMETIC 

CHEMICALS ON NUCLEIC ACID. Acta UniÃ³ internat, 


'The close similarity of the actions of free 

radicals and the mustard suggests that the 

reaction products of 

can exist in radical 

the latter with water 

or bi-radical forms. This 

is possible if the centra N or S atom loses 

one electron from a lone pair to the carbonium. 

The ease with which this electron transfer 

occurs will be determined by the binding ener 

gies of the electrons, as modified by the 

substituents. 

perties would 

On 

not 

this view nucleotoxic pro 

belong solely to two-armed 

mustards, if the energy relations were other 

wise suitable. Other types of compounds with 

nucleotoxic properties (e.g. carcinogenic 

hydrocarbons, epoxides, stilbenes, azodyes) 

can also occur in bi-radical forms, especially 

when suitably activated and it is suggested 

that the possible occurrence of such forms is 

a link between the different types of car 

cinogens and nucleotoxic substances." 

See 

1635 1761 1964 3Ãœ40 

THERAPY 

3256 Dereymaeker, A. DONNEES RECENTES EN FAVEUR DU 

TRAITEMENT NON CHIRURGICAL DES GLIOMES CEREBRAUX. 

[RECENT RESULTS IN FAVOR OF NON-SURGICAL TREAT 

MENT OF CEREBRAL GLIOMA.] Rev. neur., Par., 

1951, 84: 485-487. 

T25 7 

Seligman, A. M., Nachlas, M. M., Manheimer 

L H., Friedman, O. M. and Wolf, G. DEVELOP 

MENT OF NEW METHODS FOR THE HISTOCHEMICAL DE 

MONSTRATION OF HYDROLYTIC INTRACELLULAR EN 

ZYMES IN A PROGRAM OF CANCER RESEARCH. Ann. 

Surg., 1949, 130: 333-341. 15 refs. 

3258 Wolterhoff, H. WEITERE ERGEBNISSE AUS VERGLEI 

CHENDEN THERAPIEVERSUCHEN MIT LOST BEI IN 

OPERABLEM BLASENKREBS VERSCHIEDENER ZELLARTEN. 

[FURTHER RESULTS OF COMPARATIVE THERAPEUTIC 

EXPERIMENTS WITH MUSTARD GAS IN INOPERABLE 

CANCER OF THE BLADDER OF DIFFERENT CELL TYPES.] 

Zschr. Urol., 1953, 46: 606-623. 36 refs.



190 

SULFIDE, BIS (2-CHLOROETHYL) â€”¿ THERAPY 

(Continued) 

See 

2273 

SULFIDE, 2-CHLORO-2'-HYDROXYDIETHYL- 

3259 Seligman, A. H., Rutenburg, A. II., Persky, L. 

and Friedman, 0. II. EFFECT OF 2-CHLORO-2'- 

HYDROXYDIETHYL SULFIDE (HEHISULFUR MUSTARD) 

ON CARCINOMATOSIS 

1952, 5: 354-363. 

WITH ASCITES. Cancer, N. Y., 


Chem. Ibstr., 1952, 46: lllOSb. 

SULFID3S 

3260 

Hackmann, C. VERSUCHE ZUR CHEMOTHERAPIE 

BÃ–SARTIGER GESCHWULSTE. [CHEMOTHERAPY OF 

MALIGNANT TUMORS]. 

1948, 56; 91-106. 



med., Beet. 5, 1949, 2: No. 1109. 

SULFONAMIDES 

â€”¿ EFFECT ON MALIGNANT GROWTH 

3261 

Â»Krotkina, N. A. and Postnikova, Z. A. INFLUENCE 

OF SOME SULFONAMIDES ON THE DYNAMICS OF DEVE 

LOPMENT OF VIRUS PAPILLOMA IN RABBITS. Arkh. 

pat. Moskva, 1948, 10: No. 2, 24-31. 6 refs. 


7419a. "Sulfonamides definitely retarded the 

development of virus papilloma and its malig 

nant change, with regression in some cases. 

It was necessary to apply the drugs early 

and in large doses since they had little ef 

fect after malignant change. 

Â«ere disulfan, sulfanilamide, 

The 

and 

drugs used 

sulfathiazole, 

which were rubbed into the skin at the 

site; daily or every-other-day applications 

were necessary for effectiveness. 

was not stated." -Chem. Abstr. 

The dosage 

3262 

Freedlander, B. L., FÃ¼rst, A. and Sah, P. P. T. 

THE EFFECT OF AZO DERIVATIVES OF SULFA DRUGS 

AND 

AND 

RELATED 

MYELOID 

AMINES ON MAMMARY CARCINOMA 755 

LEUKEMIA IN C-57 BLACK MICE. 

Stanford M. Bull., 1954, 12: 33-35. 17 refs. 

Abstracted in: Excerpta mecÃ.,Sect. 16, 1954, 

2: No. 5021. 

See 

2997 3562 

THERAPY 

3263 

Hausmann, K. ÃœBER DIE GRENZEN DER BEHANDLUNG 

VON HÃ„MOBLASTEN MIT CYTOSTATISCHEN SUBSTANZEN. 

[LIMITS OF TREATMENT OF HEMOBLASTOSES WITH 

CYTOSTATIC AGENTS.] Sang, Par., 1950, 21: 

365-368. Report on 100 cases of leucoses 

treated with urethane, nitrogen mustard, 

arsenic and sulphonamides, alone or in com 

bination. 

See 

693 695 1157 2696 

TOXICITY 

3264 Lodge, K. V. and Woodcock, A. S. WIDESPREAD 

ACUTE NECROSIS OF THE LIVER FOLLOWING SULFO- 

NAMIDE THERAPY IN PATIENTS WITH LEUKEMIA. 

Am. J. Path., 1954, 30: 361-373. 

SULFONIC ACIDS 

See 

270 

SULFUR COMPOUNDS, 

See 

1316 

SURAMIN 

CYLIC 

3265 

Keil, E. ZUR FRAGE DER WACHSTUMSHEMMYNGDES 

KREBSES DURCH BAYER 205. [INHIBITION OF 

CANCER GROWTH BY BAYER 205.] Krebsarzt, 

Wien, 1952, 7: 148-153. A review. 

3266 

Williams, W. L. THE EFFECTS OF SURAMIN 

(GERMANIN), AZO DYES, AND VASODILATORS ON 

MICE WITH TRANSPLANTED LYMPHOSARCOMAS. 



217f. 

SYNKAYVITE 

see 1, 4 NAPTHOHYDROQUDJONE, TETRA SODIUM 

2-METHYL DIPHOSPHATE 

TANNIN 

3267 

Lasnitzki, A. NOTE ON THE ACTION OF TANNIN 

UPON TUMOR GLYCOLYSIS. 

1946, 40: 263-264. 

Biochem. J., Lond., 

3268 

Szarn, I., Hankovszky, M. and Sellei, C. A DAGA- 

NATNÃ–VEKEDES GATLASA CSERSAWAL. [INHIBITION 

OF TUMOR GROWTH WITH TANNIC 

orvostud., 1954, 6: 59-62. 

ACID.] Kiserletes 

18 refs. Daily 

aqueous solutions of 0.20 gm kg tannin admin 

istered subcutaneously and intraperitoneally 

to 29 rats with Guerin tumors, considerably 

reduced the weight of the tumors, especially 

in the early stages of tumor growth. Sub 

cutaneous injections of large tannin doses had 

no effect. 

TARTARIC ACID â€”¿ EFFECT ON TUMOR GROWTH 

3269 

Morel, 

Kalb, 

A., 

J. 

Josserand, A., Viallier, J. and 

EFFET SUR L'ACCROISSEMENT D'UNE 

TUMEUR EXPERIMENTALE DU RAT BLANC (SOUCHE 

T 8 DE GUERIN) DE L'ADMINISTRATION PAR VOIE 

BUCCALE D'UN COMPLEXE FERRICO-SODIQUE DE 

L'ACIDE TARTRIQUE. [EFFECT ON GROWTH OF 

EXPERIMENTAL TUMOR OF WHITE RATS (STRAIN T 

OF GUERIN) OF ORAL ADMINISTRATION OF IRON- 

8 

SODIUM TARTRATE COMPLEX.] Ann. 

Pasteur, Par., 1950, 78: 138-139. 

Inst. 

See 

1778 

THERAPY 

3270 

Morel, A. and Josserand, A. NOUVELLES RECHERCHES 

SUR L'EMPLOI DES COMPLEXES FERRICO-SODIOUES 

ORGANIQUES AU COURS DE L'EVOLUTION DES CANCERS 

(ACTION DÃ‰SINFILTRANTE DES COMPLEXES PYRUVIQUES 

ET DES COMPLEXES TARTRIQUES ADMINISTRES PAR 

LA VOIE DIGESTIVE). [NEW STUDIES ON THE USE 

OF ORGANIC IRON-SODIUM COMPLEXES DURING THE 

EVOLUTION OF CANCERS (DISINFILTRATING ACTION 

OF THE PYRUVIC AND TARTARIC COMPLEXES ADMIN 

ISTERED THROUGH THE DIGESTIVE TRACT).] J. mÃ©d. 

Lyon, 1947, 28: 1-8. Abstracted in: Excerpta 

med., Sect. 57 1948, !_: No. 317. 

Bee 

140



191 

TEPA 

see PHOSPHORAMIDE, N, N1, N"-TRIETHYLENE- 

TEROPTERIN 

see NITROGEN MUSTARDS. GLUTAMIC ACID, 

PTEROYLTRI- 

TERRAMYCIN 

see OXYTETRACYCLINE 

TESTIS EXTRACT â€”¿ THERAPY 

See 

657 

TEZAN 

3271 Vermel', E. M. and Sokolova, A. A. BOR'BA S 

LUCHEVOÃ• BOLEZN'IÃ PRI POMOSHCHI TEZANA I 

KUMARINA. [THE EFFECT OF TEZAN AND COUMARIN 

ON IRRADIATION DISEASE.] Tr . Akad. med. 

nauk SSSR. Vopr. onkol., 1954, No. 7, 255- 

267. 3 reÃs. Tezan in weekly doses of 20 

mg was administered to 45 patients with 

chiefly gynecological cancers. The drug 

counteracted leukopoenia induced by radia 

tion and caused general improvement in the 

patients' over all condition. Experimen 

tally, tezan inhibited the growth of tumors. 

Clinically, the drug has been used so far 

only in conjunction with X-ray treatment. 

Coumarin, used on 23 patients with various 

cancers, also in conjunction with irradia 

tion, showed effects similar to those of 

tezan . 

THIAZOLE, 

AMINO- 

3272 

Spampinato, V. TIROIDE E TUMORI: INFLUENZA 

DELL'AMINO-2-TIAZOLO SÃœLL'ADENOCARCINOMA DI 

EHRLICH. [THYROID AND TUMORS; THE INFLUENCE 

OF AMINO-2-THIAZOLE UPON THE EHRLICH ADENO 

CARCINOMA.] Neoplasie, Tor., 1950, 4: 81-100. 

78 refs. Ajnino-2-thiazole given in d'osÃ©sof 

1 mg over a period of 10 days to albino rats 

did not inhibit the growth of Ehrlich adenocarclnoma, 

as was reported by other investi 

gators. Endocrine equilibrium was impaired 

through the drug's effect upon the thyroid 

functions. 

THIOCYANIC 

ACID 

3273 Beickert, A. and Jorke. D. DIE WIRKUNG VON 

THIOCYÃ„NAT AUF DIE POLYCYTHAMIE. [EFFECT 

OF THIOCYANATE ON POLYCYTHEMIA. ] Klin. 

Wschr., 1953, Â¡U: 686-680. 

3274 

LÃ¼hrs, W. and Kindermann, I. ÃœBER DIE BEEIN 

FLUSSUNG DES JENSEN-SARKOMS DER WEISSEN RATTE 

DURCH EINE FIXIERTE RHODANWASSERSTOFFSAURE 

(ORTHROMIN). [EFFECT OF A FIXED THIOCYANIC 

ACID (ORTHROMIN) ON JENSEN SARCOMA IN WHITE 

RAT.] Zschr. ges . inn. Med., 1953, 8: 974- 

976. 12 refs. 

See 

1815 

THIODIGLYCOL 

see ETHANOL, 

THIONINE 

2,2'-TfflODI- 

Valerio, F. and Buscalferrl, V. AZIONE DELLA 

TIONINA SULLA CRESCITA DELL 'ADENOC ARC INOMA DI 

EHRLICH. [THE EFFECT OF THIONINE UPON THE 

GROWTH OF EHRLICH ADENOCARCINOMA.] Neoplasie, 

Tor., 1950, 4: 73-80. 7 refs. Thionine in 

1:30.000 aqueous solution was injected subcutaneously 

in doses of 0.5 cc every three 

days to 18 albino rats with transplanted 

Ehrlich adenocarcinoma. The growth of the 

tumor was slackened and decrease of the body 

weight was accentuated but survival time was 

not affected. 

TfflOTEPA 

see PHOSPHORAMIDE, TRIETHYLJNE THIO- 

THORIUM TRYPAN BLUE â€”¿ EFFECT 

See 

3536 

THYMUS GLAND 

ON CANCER IN MICE 

3276 

HarÃ¡, K. THE EFFECTS OF VARIOUS FRACTIONS OF 

THYMUS EXTRACT ON THE GROWTH OF TRANSPLANTED 

CANCER IN MICE. J. Jap. Biochem. Soc., 1947, 


ifDstr., 1950, 44: 10886b. 

3277 

Molnar, P. and Kovics, K. THYMUSKIVONAT HATXSA 

HAZINYULAK TRANSPLANTALT BROWN-PEARCE RAKJARA. 

[EFFECT OF THYMUS-EXTRACT ON TRANSPLANTED 

BROWN-PEARCE CANCER IN RABBITS.] Orv. hetil., 

1952, 93: 

tumors~Tn 

33-36. 

12 male 

16 refs. Brown-Pearce 

rabbits were treated with 

thymus-extract, administered in 15 subcutaneous 

injections totalling 90 cm-1 extract. The size 

of the tumor and their malignancy increased. 

3278 

MolnÃ¡r, P. and KovÃ¡cs, K. DIE WIRKUNG EINES 

THYMUSEXTRAKTES AUF DAS BROWN-PEARCE-KARZINOM 

DES KANINCHENS. [THE EFFECT OF THYMUS EX 

TRACT ON BROWN-PEARCE CARCINOMA OF THE RABBIT.] 

Arch. Geschwulstforsch., 1953, 5: 33-47. 


16, 1954, 2: No. 577. "Treatment of Brown- 

Pearce carcinoma bearing rabbits with a trichloracetic 

calf thymus extract caused in 

creased malignancy of the tumour with a higher 

number of mÃ©tastases located especially in 

the spleen (50%). Cytological study of the 

tumour tissue gave negative results concerning 

any direct effects of the extracts on tumour 

tissue. No enhancement in the function of 

the reticulo-endothelial system was observed 

(Congo-red test). In rats marked signs of 

increased hypophyseo-adrenocortical activity 

developed after the injection of the thymus 

extract." -Excerpta med. 

3279 

Parhon, C. I., Potop, I., Babes, A., PÃ©trea, I., 

Juvina, K.. Felix, E. and Boeru, V. ACTIUNEA 

TIMUSULUI SI A UNOVSUBSTANTENEUROTROPEIN 

CANCERULEXPERIMENTAL. [THE EFFECT OF THYMUS 

AND NEUROTROPICSUBSTANCESON EXPERIMENTAL 


Republicii 

146 p. Bucharest, 

Populare Romine, 

Academia 

1955. 48 refs. 

TISSUE EXTRACTS 



see also CELL THERAPY; ORGAN EXTRACTS; AND 

SPECIFIC ORGANS 

3280 

Â»Abdullaev, M. D. TKANEVAIA TERAPIIA V USLOVIIAKH 

EXPERIMENTAL'NOGO RAKA. [TISSUE THERAPY IN 

EXPERIMENTAL CANCER.] Doct. disser. Baku, 

Azerbaidzh. gos. med. nisi., 1954. 12 p. 

3281 Bartoli, J. SUR L'EMPLOI DE DÃ‰RIVÃ‰S DE NUCLEO- 

PROTÃ‰INESDANS LE TRAITEMENTDES EPITHELIOMAS. 

[THE USE 0F NUCLEOPROTEINDERIVATIVE IN THE 

TREATMENTOF EPITHELIOMA.] 

1949, 2: 321-323. 4 refs. 

Bull, algÃ©r. carcin. 


Index Ã¢nalyt. cancer., Par., 1949, 20: No. 370.



192 

TISSUE EXTRACTS â€”¿ EFFECT 

(Continued) 


3282 Bassenhelm, C. W. von TRATAMIENTO DEL SARCOMA 

EXPERIMENTAL CON EXTRACTOS EMBRIONARIOS; 

COMUNICACIÃ“N PREVIA. Ã•TREATMENT OF EXPERI 

MENTAL SARCOMA WITH EMBRYONIC EXTRACTS; PRE 

LIMINARY COMMUNICATION.] Dia ned., B. Air., 

1953, 25: 405-408. 

32Bennett, L. R., Connon, F. E., Gouze, M. L. 

and Schoenberg, M. D. FURTHER STUDIES ON 

EFFECTS OF A SMALL, INTESTINAL MICROSOMAL 

FRACTION ON TRANSPLANTABLE TUMORS. Proc. 

Soc. Exp. Biol., N. Y., 1953, 82: 665-668. 

Abstracted In: Excerpta med., Sect. 16, 

1954, 2: No. 578. 

Cevese, P. G. and Ferro, A. SULL'AZIONE ANTI- 

NEOPLASTICA DI ESTRATTI DI TESSUTI NORMALI; 

RICERCHE SPERIMENTALI; NOTA PRELIMINARE. 

[THE ANTINEOPLASTIC ACTION OF EXTRACTS OF 

NORMAL TISSUES; EXPERIMENTAL STUDIES; PRE 

LIMINARY NOTE.] Riv. anat. pat., 1951, 4: 

78-85 17 reÃs. Abstracted in: Excerpta 

med., Sect. 5, 1952, 5: No. 3158. "...in 

rats sarcomas induced~by inoculation(the 

original strain was a benzpyrene sarcoma) 

were treated with injections of total ex 

tracts from homologous animals(no extracts 

of the skin, alimentary canal or sex glands 

were used, however). In 16 out of 26 treated 

animals the tumour disappeared, particularly 

when the treatment consisted in subcutaneous 

injections." - Excerpta med. 

OOQC 

Eser S ACTION OF CERTAIN ADRENAL CORTEX STI 

MULATING SUBSTANCES ON THE COURSE OF TUMORS. 

Istanbul. Contrib. Clin. Se., 1952-1953, 2: 

313-320. 83 reÃs. 

Funk C., Ehrlich, A., Tomashefsky, P. and 

Soukup, R. A NEW CRITERION FOR ANTI-TUMOR 

ACTIVITY OF TISSUE EXTRACTS USING CROCKER 

SARCOMA NO. 180 IN MICE. Proc. Soc. Exp. 

Biol., N. Y., 1950, 75: 674-675. rÃ©f. 


41 No. 2770. 

3287 Gigante, D. INFLUENCE DE LA GRAISSE HUMAINE 

SUR L'ACTIVITÃ‰ CANCÃ‰RIGÃˆNEDU BENZOPYRENE. 

[THE EFFECT OF HUMAN FAT ON THE CANCEROGENIC 

ACTION 0F BENZOPYRENE.] Rev. belge path., 

1949, 19: 282-297. 39 reÃs. 

Â»t O. M. MAMMARY TUMOR REGRESSION BY EX 

TRACTS OF HISTOLYZED AMPHIBIAN SKIN AND GILLS. 


317. refi "...extracts made from hlStolyzing 

larval anuran gills, similar to those made 

from degenerating larval anuran tail skin, 

contain some substance or substances which 

exert an inhibitory and regressive influence 

on spontaneous mammary tumors of mice." 

"ÃŽ289 

Helff, O. M. REGRESSION AND REABSORPTION OF 

MAMMARY TUMORS BY EXTRACTS OF DEGENERATING 

AMPHIBIAN SKIN. Proc. Soc. Exp. Biol., N. Y., 

1948, 69: 336-338. 2 refs. 

32Hoffman, R. S., Dingwall, J. A. and Andrus Â». 

DeW IN VITRO STUDIES OF A GROWTH INHIBITORY 

FRACTION OBTAINED FROM ADULT SHEEP CARDIAC 

MUSCLE. Proc. Soc. Exp. Biol., N. Y., 1948, 


iÃ«d., Sect. 5, 1949, 2: No. 3178. 

3291 

Jones, Â»nes.i,.u. L. O. IN VITRO STUDIES ON THE EFFECT OF 

GROWTH'OFâ„¢ARCOMA



193 

TISSUE EXTRACTS 


(Continued) 

3300 Hammerschmid, J. 'ÃœBERDIE WIRKUNG VON EXTRAKTEN 

AUS TIERISCHEN 

KREBSKRANKEN. 

WUNDGRANULATIONSGEWEBEN BEI 

[EFFECTS OF EXTRACTS FROM ANI 

MAL WOUND GRANULATION TISSUES 

Munch, med. Wschr., 1953, 95: 

ON CANCER PATIENTS.] 

1049-1052. 

4 refs. Intramuscular injections of extracts 

from animal wound granulation tissue was ad 

ministered to 75 inoperable cancer patients. 

General improvement, a decrease in the mÃ©tastases 

and in a few cases a regression of the tumor 

occurred. The composition of the extract is 

not given. 

3301 

Koressios, N. T. LE PROBLÃˆME TISSULAIRE ET 

ANTI-TISSULAIRE: SES APPLICATIONS DANS LA 

THERAPEUTIQUE DU CANCER. [THE TISSULAR AND 

ANTI-TISSULAR PROBLEM: ITS APPLICATION IN 

CANCER THERAPY.] 194p. Paris, Maloine, 

1952. A review. 

3302 

Kressner, A. EIN BERTRAG ZUR MALIGNOMBEHAND 

LUNG MIT WUNDGRANULATIONSEXTRACT (WGH). 

[CONTRIBUTION TO THE TREATMENT OF MALIGNOMA 

WITH WOUND GRANULATION EXTRACT (WGH).] 

Munch, med. Wschr., 1954, 96: 855-858. 

2 refs. 

See 

WUNDHORMONE GEGEN KREBS. [WOUND HORMONES AGAINST 

CANCER.] Orion, 1953, 8: 980. Essentially 

a review of Dr. J. Hammerschmid's article in: 

Munch, med. Wschr., 1953, 95: 1042-1052. 

1810 3115 3681 

TISSUE EXTRACTS. AF2 â€”¿EFFECT ON TUMOR 

GROWTH 

3304 

Antonucci, C. MORFINA. AF2 E TUMORI. [MOR 

PHINE, AF2 AND TUMORS.] Ter. ned. tumori, 

1948, 1: 43-44. Mice with tumors were 

treated with morphine and AF2 simultaneously. 

It was shown that morphine interfered with 

the antineoplastic properties of AF2. AF2 

contains no morphine or related alcaloids 

and should not be used in a combined therapy 

with morphine. 

3305 

Guarnieri, F. ESAME FARMACOLOGICO DEL PRE 

PARATO NEOAF2. [PHARMACOLOGICAL EXAMINA 

TION OF THE SUBSTANCE NEOAF2.] Ter. med. 

tumori, 1953, 3: 51-54. The composition 

of the drug, its toxicity and anti-neoplastic 

properties on the various organs 

and general metabolism is discussed. 

3306 

Guarnieri, F. IL FATTORE FA2. [THE FA2 FACTOR.] 

Fisiol. & med., Roma, 1947, 15: 181-184. 

3307 

Puoti, A. CANCRO E ACIDO 

FOLIC ACID.] Ter. med. 

FOLICO. 

tumori, 

[CANCER AND 

1948, 1_:45- 

46. A comparison is drawn between the action 

of triglutamic folie acid and AF2, both vita 

mins are found 

anti-neoplastic 

in the liver 

properties. 

and both have 

THERAPY 

3308 

Antonucci, G. TUMORE PRIMITIVO DEL POLMONE 

TRATTATO CON FATTORE AF2 (S.R.P.). [PRIMARY 

TUMOR OF THE LUNG TREATED WITH AF2 (SERUM 

STIMULATING THE RETICULAR SYSTEM).] Ter. med. 

tumori, 1949, 2J 164-171. English summary. 

AF2 treatment was begun following unsuccessful 

X-ray treatment. As a result of the acti 

vation of the reticulo-endothelial system 

the mÃ©tastases decreased and the overall 

condition of the patient improved.] 

3309 

Beruto, L. RISULTATI DEL TRATTAMENTO CON AF2 

SU UN CASO DI SARCOMA DEL PIEDE. [RESULTS 

OF AF2 TREATMENT IN ONE CASE OF SARCOMA OF THE 

FOOT.] Ter. med. tumori, 1949, 2: 284-287. 

English summary. Following one and one half 

year of exclusive AF2 therapy, lesions re 

sulting from a sarcoma of the calcaneun dis 

appeared, and the man was able to resume his 

job as a laborer. 

3310 

Gentili, B. CONSIDERAZIONI SU 164 CASI DI TU 

MORE DELL'OVAIO. [OBSERVATIONS IN 164 CASES 

OF OVARY TUMORS.] Ter. med. tumori, 1949, 

2: 220-228. English summary. Of 164 cases 

o~f ovary tumors treated with AF2 injections 

one complete recovery was observed following 

two years of treatment with the substance. 

In all the other cases AF2 improved the over 

all condition of the patients as well as 

prolonged their survival time. 

3311 

Gentili, B. SU 218 CASI DI TUMORE DELLA VESCICA 

TRATTATI CON FATTORE AF2. [TREATMENT OF 218 

CASES OF TUMORS OF THE BLADDER WITH AF2.] 

Ter. med. tumori, 1949, 2: 288-295. English 

summary. Aside from general improvement in 

the patient's condition, reduction of the 

tumor mass occurred in 12 cases and complete 

clinical recovery in 2 cases. 

3312 

Gentili, B. TECNICA TERAPEUTICA CON IL FATTORE 

AF2. [THERAPEUTIC TECHNIQUE WITH AF2.] Ter.- 

med. tumori, 1948, 1: 32-36, 214-216. A 

survey of the methods employed in treating 

cancer patients with AF2. Uterine and laryngeal 

cancer and their treatment with AF2 

injections are discussed in detail. 

3313 

Gentili, B. and Puoti, A. SU DUE CASI DI CANCRO 

DELLA MAMMELLA. [TWO CASES OF MAMMARY CANCER.] 


summary. Injections of AF2 to two patients 

with mammary cancer resulted in the reduction 

of the lymph glands, a normalized blood picture 

and general improvement in the overall condi 

tion of the patients. 

3314 

Guarnieri, F. IL COMPLESSO ANTICANCEROSO A.F.2. 

[THE A.F.2 ANTICANCEROUS 

mil., 1947, 94: 157-159. 

COMPLEX.] Gior. 


med. 


"The chemical composition of tin complex is 

presented. It was given a trial in nearly 

5,000 patients with malignant neoplasms in 

different organs, verified clinically, radiologically 

and histologically. General im 

provement (not recovery) was observed in 70% 

of the cases. Treatment and reactions are 

described. Patients who had not previously 

been treated surgically or by irradiation 

reacted best to treatment 

complex." - Excerpta med. 

with the A.F.2 

3315 

Guarnieri, F. EL HÃ•GADO EN LA ETIOPATOGENESIS 

Y EN LA TERAPIA DE LOS TUMORES. [THE LIVER 

IN THE 

MORS.] 

ETIOPATHOGENESIS 

113 p. Buenos 

AND THERAPY OF TU 

Aires, Armando Mariti, 

1948. 

3316 

Guarnieri, F. LA TERAPIA MEDICA DEI TUMORI E 

L'AF2. [MEDICAL THERAPY OF TUMORS AND AF2.] 

Ter. med. tumori, 1949, 2: 266-283. Pro 

ceeding from the theory thai by stimulating 

the reticulo-endothelial system cancer can 

be effectively combatted, a liver and spleen 

extract designated as AF2 was investigated. 

The composition of the drug, its effect on 

the RES, experimental and clinical results, 

toxicity and 

with hormone 

findings of AF2 in combination 

and X-ray therapy are reported.



194 

TISSUE EXTRACTS. 

(Continued) 

AF2 â€”¿ THERAPY 

3317 

Guarnieri, F. and Gioia, M. SUL COMPLESSO 

ANTINEOPLASTICO GUARNIERI (A. F. 2) NELLA 

CURA DEI TUMORI MALIGNI. [THE ANTINEO- 

PLASTIC COMPLEX GUARNIERI (AF2) IN THE 

TREATMENT OF MALIGNANT TUMOR]. Fisiol. & 

med., Roma, 1947, 15: 89-92. Two cases of 

secondary liver carcinoma treated with AF2 

showed improvement in the overall condition. 

Softening of the tumor mass also occurred. 

3318 

Mancini, N. CANCRO A CORAZZA DELLA MAMMELLA 

TRATTATO CON FATTORE AF2 E FOLLIDIENE TIPO B. 

[MAMMARY CANCER TREATED WITH AF2 AND FOLLIDINE 

B.] Ter. med. tumori, 1948, 1.:248-250. 

3319 

Puoti, A. CANCRO DELLO STOMACO; CASISTICA E 

OSSERVAZIONI. [CANCER OF THE STOMACH; CASE 

HISTORIES AND OBSERVATIONS.] 

1948, ^: 107-115. Four case 

Ter. med. tumori, 

histories are discussed. 

In one case complete disappearance of 

the tumor was observed while in the other cases 

partial regression of the tumor mass and general 

improvement in the overall condition of the 

patients occurred. 

3320 

Puoti, A. CONSIDERAZIONI SU 35 CASI DI TUMORE 

DEL TESTICOLO. [OBSERVATIONS IN 35 CASES OF 

CANCER OF THE TESTICLE.] Ter. med. tumori, 

1949, 2: 98-107. 17 reÃs. English 

Of the~35 patients treated with AF2 

summary. 

only one 

showed complete regression of the tumor; in 

9 cases partial regression occurred, while 

in the remaining cases only absence of pain 

and slight overall improvement in the gen 

eral condition was observed. 

3321 

Puoti, A. IL SISTEMA RETICOLO ISTIOCITARIO 

NELLA DIFESA ANTINEOPLASTICA. [THE RETICULO- 

ENDOTHELIAL SYSTEM IN THE ANTI-NEOPLASTIC 

COMBAT.] Ter. med. tumori, 1949, 2: 1-19. 

76 refs. English summary. In connection 

with cancer therapy the Bogomolets antireticular 

cytotoxic serum and the Guarnieri 

serum stimulating the reticulo-endothelial 

system are discussed. The greater effective 

ness of the latter is illustrated by findings 

in one case of subacute erythremia. 

3322 

Puoti, A. TECNICA TERAPEUTICA CON IL FATTORE 

AF2. [THERAPEUTIC TECHNIQUE WITH AF2.] Ter. 

med. tumori, 1948, 1: 13-15, 67-70, 122-124, 

146-147, 228-230. A~series of articles on 

treatment with AF2. Clinical results obtained 

in cancer of the intestine, of the mammary 

gland and of the stomach are reported. 

3323 Ries, J. and Biaslu, A. P. ERFAHRUNGEN MIT DEM 

PRÃ„PARAT FAKTOR AF2 GUARNIERI BEI DER BEHAND 

LUNG VON KREBSKRANKEN. [TREATMENT OF CANCER 

WITH THE GUARNIERI AF2 PREPARATION.] Med. Klin., 

Beri., 1954, 49: 999-1002. 8 refs. The gen 

eral condition~~of 861 patients treated with 

AF2 improved, but no tumor regression was noted. 

3324 

Romero Velasco, E. LA CURA DEL CANCER POR EL 

COMPUESTO AF2. [THE TREATMENT OF CANCER 

WITH AF9.1 

134-1367 

Medicamenta, Madr., 1947, 5: 

3325 Scalone, I. I RISULTATI DEL TRATTAMENTO COL 

FATTORE AF2 SU 65tÃAMMALATE DI CANCRO IN 

OPERABILE DELLA MAMMELLA. [RESULTS OF AF2 

TREATMENT OF 656 PATIENTS WITH INOPERABLE 

MAMMARY CANCER.] Ter. med. tumori, 1948, 

1: 234-248. 

3326 

Schwerdtfeger, H. and UexkÃ¼ll, T. von KLINISCHE 

ERFAHRUNGEN MIT DEM PRÃ„PARAT AF2. [CLINICAL 

EXPERIENCES WITH THE PREPARATION AF2.] Deut. 

med. Wschr., 1950, 75: 388-392. Various tumors 

and leukemias in 22~Tnoperable patients were 

treated with AF2. General improvement in the 

overall condition of almost all patients, and 

regression of tumor growth in one patient oc 

curred. 

3327 

Schwerdtfeger, H. and UexKÃ¼ll, T. von KLINISCHE 

ERFAHRUNGEN MIT DEM PRÃ„PARAT AF2. II. [CLI 

NICAL 

1952, 

RESULTS WITH 

94: 212-219. 

AF2.] Munch, med. Wschr., 

A survey of the findings 

in treatment with AF2 of various cancers mostly 

gynecological over a period of 2 years in 

Germany. It could not be ascertained whether 

the drug could cause tumor regression, but it 

was observed that it improved the overall con 

dition of cancer patients. 

3328 

Spechterj J. ERFAHRUNGEN IN DER BEHANDLUNG MIT 

DEM PRÃ„PARAT AF2. [EXPERIENCE 

MENT.] Aerztl. Forsch., 1951, 

WITH AF2 TREAT 

5: No. 8, 81- 

86. 8 refs. 

3329 

Stella, A. INFILTRAZIONE NEOPLÃ•STICA DEL TERZO 

INFERIORE DELL'ESOFAGO TRATTATA CON FATTORE 

AF2 (S.R.P.). [NEOPLASTIC INFILTRATION IN THE 

LOWER THIRD OF THE ESOPHAGUS TREATED WITH AF2] 


summary. One case of inoperable cancer of the 

esophagus which had been unsuccessfully treated 

with X-rays was treated with AF2. Complete 

cure was obtained. No details are given. 

3330 

Stella, A. SU UN CASO DI CORIONEPITELIOMA 

DELL'UTERO CON METASTASI VAGINALE TRATTATO 

COL FATTORE AF2 (S.R.P.) - GUARIGIONE. 

[ON ONE CASE OF CHORIONEPITHELIOMA OF THE 

UTERUS WITH VAGINAL METASTASES TREATED WITH 

AF2 - RECOVERY.] Ter. med. tumori, 1949, 

2: 159-163. English summary. Following 

partial hysterectomy the patient was treated 

with AF2 injections.1 Complete recovery oc 

curred within 2 years. The tumor mass had 

disappeared and no inflammatory or neoplastic 

lesions could be observed. 

3331 

LE TRAITEMENT DU CANCER PAR LA MÃ‰THODE "GUARNERI" 

[SIC], [TREATMENT OF CANCER WITH THE GUARNIERI 

METHOD.] Schweiz, med. Wschr., 1947, 77: 1189- 

1190. According to official experiments under 

the Direzione Generale della SanitÃ Publica 

in Rome, the AF2 substance cannot be considered 

as antineoplastic; it gives only palliative 

effects. 

See 

3583 

TISSUE EXTRACTS. TUMOR â€”¿EFFECT ON TUMOR 

GROWTH 

3332 Aptekman, P. A METHOD OF PRODUCING ONCOLYSIS 

IN RATS THAT CONFERRED A CERTAIN IMMUNITY 

AGAINST HOMOLOGOUS TUMORS. In: APPROACHES 

TO TUMOR 

Advance. 

CHEMOTHERAPY. 

Sc., 1947, p. 

Wash., 

58-63. 

Am. Ass. 

Discussion: 

p. 61-63. 10 refs. 

3333 

Aptekman, P. M. and Lewis, M. R. EVIDENCE OF 

RESISTANCE TO TUMOR 

INDUCED ONCOLYSIS. 

GRAFT IN EARLY STAGES OF 

J. Immun., 1951, 66: 361- 

364. 4 refs.



195 

TISSUE EXTRACTS. TUMOR â€”¿ EFFECT 

TUMOR GROWTH (Continued) 

ON 

3334 

Aptekman, P. H .., Lewis, M. R. and King, II,D. 

UNE METHODE POUR PRODUIRE DANS UNE LIGNEE 

DE RATS ALBINOS UN HAUT POURCENTAGE D'ANIMAUX 

IMMUNS CONTRE LES TUMEURS HÃ‰RÃ‰DITAIREMENT 

HABITUELLES DANS CETTE LIGNEE. [A METHOD 

OF PRODUCING IN INBRED ALBINO RATS A HIGH 

PERCENTAGE OF IMMUNITY FROM TUMORS NATIVE 

77-86. 

IN THEIR 

19 

STRAIN.] 

refs. Tumor 

J. Immun., 

"concentra 

1946, 

te~Â¡^ 

52: 

prepared from the distilled pulp of primary 

induced tumors and transplanted tumors , 

injected into rats with sarcomata pro 

duced by l:2:5:6-dibenzanthracene, 2:3 

benzypyrene or methylcholanthrene dissolved 

in olive oil, destroyed the tumors in 56 

of 58 animals treated. 78.1% of a number 

of healed rats were immune to 2-3 subsequent 

grafts of the same kind of tumor and 60% 

were immune to the growth of other tumors . 

3335 

Domagk, G. DIE BEDEUTUNG KÃ–RPEREIGENER 

ABWEHRKRÃ•FTE FÃœR DIE ANSIEDLUNG VON GE 

SCHWULSTZELLEN. [THE SIGNIFICANCE OF 

BODILY RESISTANCE IN THE CONTROL OF TU 

MOR CELLS.] Zschr. Krebs forsch. , 1949, 

56: 247-252. Abstracted in: Excerpta 

Sed., Sect. 5, 3: 1950, No. 1121. 

3336 

Duboucher, H. and Czerkinsky, G. AUTO-ANTIBIOSE 

(MEMOIRE PRELIMINAIRE). [AUTO-ANTIBIOSIS; 

PRELIMINARY REPORT.] Bull algÃ©r cancer., 1948, 

1: 174-184. Abstracted in: Index analyt. 

cancer., Par., 1948, 19: No. 647. 

3337 

Graff, S., Antopol, W. , Zagal, G. and Agate, F. 

INFLUENCE OF SARCOMA 180 ON ADENOCARCINOMA 

755 IN THE MOUSE. 

383-384. 2 refs. 


"Sarcoma 180 

1952, 12: 

appears to 

inhibit the growth of carcinoma 755, but 

carcinoma 755 enhances 

sarcoma 180." 

the growth rate of 

3338 

Horava, A. HAEMORRHAGIC NECROSIS INDUCED IN A 

TRANSPLANTED MALIGNANT TUMOUR BY A BIOLOGICAL 

FLUID. CaÃ±ad. M. Ass. J., 1954, 70: 676-680. 

10 refs. "...the liquid accumla tTHg under 

certain conditions in the Walker 256 tumor 

exerts lytic properties against the same neo 

plasm." 

3339 

Horava, A. and Adamkiewicz, V. W. SUR QUELQUES 

PROPRIETES DE L'EXSUDAT TUMORAL. [SOME 

PROPERITIES OF TUMOREXUDATES]. Rev. caÃ±ad. 

biol., 1953, 12: 441-443. 

3340 

Lewis, M. R., Aptekman, P. H. and King, R. D. 

INACTIVATION OF MALIGNANT TISSUE IN TUMOR- 

IMMUNE RATS. J. Immun., 1949, 61_: 321-326. 

4 refs. Rats cured of tumors by treatment 

with rat sarcoma extract became resistant 

to growth of transplanted tumors. "Tumor 

tissue introduced into tumor-immune rats 

remained viable for three days but was com 

pletely inactivated on the fourth day. 

The period of viability was shortened to 

24 hours in rats in which tumor tissue in 

troduced four 

vitalized." 

days earlier, had become 

3341 

Lewis, M. R., King, H. D., Aptekman, P. M. and 

Seibert, F. B. FURTHER STUDIES ON ONCOLYSIS 

AND TUMOR IMMUNITY IN RATS. J. Immun., Bait., 


Biol. Sbstr., Bait., 1950, 24: No. 2036. 

3342 

Roussy, G. and Gu



196 

TOXINS 

see BACTERIA. 

DIPTHERIA. 

TRACIN 

TOXINS 

TOXINS 

3349 

Gregory, J. E. BACILLUS SUBTILIS AS AN ANTI 

BIOTIC IN THE TREATMENT OF CANCER. South. 

M. J., 1950, 43: 397-403. 2 refs. 

TRIAZINE, 3,5-DIHYDROXY-6-METHYL-1, 2-4- 

3350 

Prusoff, W. H., Holmes, W. L. and Welch, A. D. 

BIOLOGICAL INVESTIGATIONS OF 6-AZATHYMINE, 

A THYMINE 

570-574. 

ANALOG. 

29 refs. 


S - TRIAZINE, 

2,4,6-TRIETHYLENIMINO_ 

3351 

CONFERENCE ON TRIETHYLENE MELAMINE. Acta Haemat., 

Basel, 1952, 8: 116-127. Abstracts of papers 

presented at the Conference held at the Bronx 

Veterans Administration Hospital, Bronx, N. Y., 

February 1952. These abstracts have not been 

analyzed individually in this bibliography. 

3352 Rocchietta, S. LA TRIETILENMELA1UNA, CHEMIO 

TERAPICO ANTICANCEROSO, [TRIETHYLENE Â«SLA 

MINE, A CANCER-CHEMOTHERAPEUTIC AGENT.] 

Boll. chim. farm., 1952, 91.: 407-409. 

See 

2325 


3353 

Barvick, L. and Goodson, L. H. EFFECTS OF COM 

BINED CHEMOTHERAPY 

SPECIAL REFERENCE 

ON SARCOMA 180, WITH 

TO FOOD INTAKE, BODY-WEIGHT 

CHANGES, AND 

Inst., 1954, 

SURVIVAL TIME. J. Nat. Cancer 

15: 177-189. 21 refs. 

3354 

Brugsch, J. and Tichter, E. ÃœBER DAS AUFTRETEN 

VON MITOSEN IM STRÃ–MENDEN BLUT 

LUNG MYELOISCHER LEUKÃ„MIEN MIT 

BEI DER BEHAND 

TRIÃ„THYLEN- 

MELAMIN. [MITOSES IN THE CIRCULATING BLOOD 

DURING TREATMENT OF MYELOGENOUS LEUKEMIA BY 

TRIETHYLENE MELAMINE.] Zschr. ges. inn. Med., 


Excerpra med., Sect. 16, 1955, 3: No. 1901. 

3355 

Buckley, s. M., Stock, C. C., Crossley, M. L. 

and Rhoads, C. P. INHIBITION OF THE CROCKER 

MOUSE SARCOMA 180 BY CERTAIN ETHYLENIMINE 

DERIVATIVES AND RELATED COMPOUNDS. Cancer, 



3356 

Burchenal, J. H., Crossley, M. L., Stock, C. C. 

and Rhoads, C. P. THE ACTION OF CERTAIN 

ETHYLENIMINE (AZIRIDINE) DERIVATIVES ON MOUSE 

LEUKEMIA. Arch. Biochem., N. Y., 1950, 26: 

321-323. 7 refs. Mice of Akm stock sub3ected 

to leukemia Ak4 Â»ere given intraperitoneally 

0.55-4 mg kg of 2,4,6-triethylenimino-striazine. 

33-115%. 

Survival time was increased from 

3357 Burchenal, J. H., Johnston, S. F., Cremer, M. A., 

Webber, L. F. and Stock, C. C. CHEMOTHERAPY 

OF LEUKEMIA. V. EFFECTS OF 2,4,6-TRIETHYLEN- 

IMINO-S-TRIAZINE AND RELATED COMPOUNDS ON 

TRANSPLANTED MOUSE LEUKEMIA. Proc. Soc. Exp. 

Biol., N. Y., 1950, 74: 708-712. 13 refs. 

Abstracted in: Biol ,~A~bstr., Bait., 1951, 

25: No. 23848; Chem. Abstr., 1950, 4Â£: 101571. 

3358 

Burchenal, J. H., Webber, L. F., Biedler, J. L., 

Meigs, G. M. and Stobbe, G. D. THE EFFECTS 

OF TRIETHYLENE MELAMINE AND RELATED COMPOUNDS 

ON THE LEUKOCYTES OF MOUSE LEUKEMIA. Blood, 

Bait., 1951, 6: 504-512. 12 refs. Abstracted 


Biol. Abstr., Bait., 1951, 25: No."33790. 

3359 

Cardinali, G., Caprino, G. and Pisciteli!, N. 

COMPORTAMENTO DELLA REAZIONE DI HOTCHKISS 

NEL DANNO EPATICO PROVOCATO SPERIMENTALMENTE 

CON ALCUNE SOSTANZE ANTIMITOTICHE. [THE BE 

HAVIOR OF HOTCHKISS' REACTION IN EXPERIMENTAL 

HEPATIC DAMAGE PRODUCED BY VARIOUS ANTIMITO- 

TIC SUBSTANCES.] 

176-83. 6 refs. 

Tumori, MilanÂ«, 1954, 40: 

High doses of triethylene 

melanine and nitrogen mustard reduce hepatic 

glycogen and produce necrotic lesions in 

animals with mesenchymal tumors. 

3360 

Cobb, J. P. TISSUE CULTURE OBSERVATIONS OF 

THE EFFECTS OF CHEMOTHERAPEUTIC AGENTS ON 

HUMAN TUMORS. 

17: 237-249. 

Tr. N. York Acad. 

"...data represent 

Sc., 1955, 

observa 

tions of 32 TEM exposed tissue culture series 

and 10 culture series exposed to Puromycin." 

3361 

Crossley, M. L., Allison, J. B. and Muenzen, 

J. B. CHEMOTHERAPY OF TUMORS IN RATS. II 

TREATMENT OF FLEXNER-JOBLING CARCINOMA IN 

SPRAGUE-DAWLEY RATS WITH 2,4,6-TRIETHYLEN- 

IMINO-S-TRIAZINE (TEM). Proc. Soc. Exp. 

Biol., N. Y., 1952, 80: 452-455. 2 refs. 

Triethylene melamine produced cures in 

about 70% of the rats treated. 

3362 

Darcel, C. le Q. OBSERVATIONS ON THE EFFECT 

OF TRIETHYLENE MELAMINE, AMINOPTERIN, AND 

A-METHOPTERIN ON THE GROWTH OF TRANSPLANTABLE 

AVIAN LYMPHOID TUMORS. 

8: 278-280. 13 refs. 

Brit. J. Pharm., 1953 

Abstracted in: Chem 

Ã¯bstr., 1954, 48: 883h. 

3363 

Grushina, A. A. and Laskina, A. V. DEISTVIE 

2,4,6-TRIETILENIMINO-S-TRIAZINA NA PEREVIV- 

NUIU SARKOMU 45 BELYKH KRYS. [EFFECT OF 

2,4,6-TRIETHYLENIMINO-S-TRIAZINE ON TRANS 

PLANTED SARCOMA 45 IN WHITE MICE.] Tr. 

Akad. med. nauk 

No. 7, 157-167. 

SSSR. Vopr. onkol., 1954, 

8 refs. TET in doses of 

0.5-0.2 mg injected intravenously into 44 

rats with sarcoma 45 caused distrophic 

changes in the tumor tissue, inhibited the 

growth of the sarcoma and gave rise to collagenization 

of the tumor edge. The spleen, 

bone marrow and the lymph nodes atrophied 

also. 

3364 

Lewis, M. R. and Crossley, M. L. RETARDATION 

OF TUMOR GROWTH IN MICE BY ORAL ADMINISTRA 

TION OF ETHYLENIMINE DERIVATIVES. Arch. 

Biochem. 

Abstracted 

N. 

in: 

Y., 

Chem. 

1950, 

Ab"s~tr.,1950, 

26: 319-320. 

44: 

2 refs. 

6513h; 

Excerpta med., Sect. 2, 1951, 4: NoTT.615. 

Triethylenimino-s-triazine and hexamethylenediethylenurea 

were added in amounts of 0.001- 

0.15% by dry weight to the diets of mice bear 

ing several types of sarcomata and carcinomata. 

Considerable retardation of tumor re 

sulted. No lung tumors appeared in any of 

these animals but developed in 20% of the 

control mice. 

3365 

McCoy, J. R., Crossley, M. L. and Allison, J. B. 

THE TREATMENT OF CANCER IN DOGS WITH 2,4,6- 

TRIETHYLENIMINO-S-TRIAZINE AND RELATED PRO 

DUCTS. Cancer Res., 1953, lj 37. An abstract.



197 

S-TRIAZINE, 2,4,6-TRIETHYLENlMINOâ€”EFFECT 


3366 Haklno, S., Tanaka, T., Kano, K. and Umetani, M. 

INHlÃ©lTIÃ“NOF TUMOR GROWTH IN ASCITES TUMORS 

BY SOME MEÂ» CHEMICALS. Gann, Tokyo, 1954, 

45: 490-493. In Japanese Report on ef- 

Ã®Ã«~ctsof podophyllotoxin, d -and /d -pelatin, 

Quercetin and TEM on rat tumors. 

3367 Schmidt, K. H. EXPERIMENTELLE UND VERGLEICHENDE 

ERGEBNISSE MIT TRIÃ„THYLENMELAMIN, N,N',N"-TRI- 

Ã„THLENPHOSPHORSÃ„UREAMID UND 6-MERCAPTOPURIN. 

[EXPERIMENTAL AND COMPARATIVE RESULTS WITH 

TRIETHYLENE MELAMINE, N,N',N''-TRIETHYLENE 

PHOSPHORAMIDE AND 6-MERCAPTOPURINE.] Arzneimitt. 

Forsch., 1954, 4: 146-161. 155 refs. Review, 

describing the effects of TEM, TEPA, and 6- 

mercaptopurine on a variety of tumors Â»hen given 

in different doses to various animals and to 

humans. 

3368 Sparks, S. J., Stevens, M. L., Landes, M. J., 

Halliday, S. L., McKenzie, D. and Williams, 

J. H. THE EFFECT OF A SERIES OF ETHYLENIMINE 

DERIVATIVES ON MYELOID CHLOROLEUKEMIA IN THE 

RAT. Blood, Bait., 1953, 8: 655-660. 22 refs. 

"The following compounds were found to be 

very active agaisnt this leukaemia: triethylene 

melamine (TEM); phosphoric acid triethylenimide 

(TEPA); N-pentamethylene-N'-N"' diethylenephosphoramide; 

N,N',N't-tris-(l-methylethylene) 

phosphoramide; N-(3-oxapentamethylene)-NI, N1'- 

diethylenephosphoramide; octyl N, N'-diethylenediamidophosphate; 

N,N' ,N" -triethylenethiopnosphoramide 

(Thio-TEPA). All of the compounds 

effectively prolonged survival time and caused 

the blood picture to approximate to that of 

non-leukaemic controls. The phosphoramides 

have the advantage of being considerably less 

toxic for rats than TEM. ThioTEPA consistently 

gave a slightly more rapid response than the 

others. " 

3369 

Sugiura, K. and Stock, C. C. STUDIES IN A TU 

MOR SPECTRUM. II. THE 

ETHYLENIMINO-S-TRIAZINE 

EFFECT 

ON THE 

OF 2,4,6-TRI- 

GROWTH OF A 

VARIETY 

Phila., 

OF BOUSE AND RAT TUMORS. Cancer, 

1952, Â£: 979-991. 24 refs. 

3370 

TEM. South. M. J., 1952, 45: 1194. 

An editorial and short review. 

5 refs. 

3371 

Â«Villa, L., Polli, E. and Semenza, G. PRIMI 

RISULTATI DI RICERCHE SÃœLL'ATTIVITÃ„DELLA 

TRIETILENMELAMINA(TEM) IN VITRO SU SANGUE 

LEUCEMICO. [PRELIMINARY EXPERIMENTALDATA 

ON THE ACTION OF TRIETHYLENEMELAMINE(TEM) 

ON LEUKEMICBLOODIN VITRO.] Gior. ital. 

chemioter., 

in: Excerpta 

1954, 

med.,"Sect. 

!_: 98-100. 

16, 1955, 

Abstracted 

3: No. 

See 

2698. 

20 991 

1946 2143 

â€”¿-EFFECT 

1341 

2531 

1911 

2783 


1922 

3372 

3372 

Antlkajian, G., Wright, L. T., Plummer, J. I. 

and Weintraub, S. THE EFFECT OF TRIETHYLENE 

MELANINE, AUREOMYCIN, AND SOME 4-AMINO DERI 

VATIVES OF FOLIC ACID ON TISSUES IN VITRO. 

J. Nat. Cancer Inst., 1951, 12; 269-274. 


5, 1952, 5: No. 3154. 

3373 

Â«Lenti, G. and Gavosto, F. MODIFICAZIONI EMATO- 

LOGICHE IN CORSO DI TRATTAMENTO CON T.E.M. 

[HEMATOLOGICAL CHANGES DURING TREATMENT WITH 

T.E.M.] 105-107. Gior. Abstracted ital. chemioter., in: Excerpta 1954, med.,"Sect. 1^: 

16, 1955, 3r No. 2758. 

3374 Leonardelli, G. and Pizzetti, F. L'EFFETTO DI 

ALCUNE SOSTANZE AD AZIONE ETILENIMINICA 

TESSUTO LINFO-EPITELIALE DELLA TONSILLA 

SUL 

PALA 

TINA. [EFFECT OF VARIOUS SUBSTANCES WITH AN 

ETHYLENIMINE ACTION ON LYMPHOID AND EPITHE 

LIAL TISSUE OF THE TONSILS.] Tumori, Milano, 

1954, 40: 647-658. tab. 7 refs. English 

summary. Abstracted in: Excerpta med., Sect. 

16, 1955, 3: No. 2700. 

See 

273 2550 346Â« 


3375 L'Ã»hrs,W. and Willig, H. ÃœBER DEN EINFLUSS 

VON HYALURONIDASE UND 2,4,6-TRIAETHYLENIMINO- 

1,3,5-TRIAZIN (TEM) AUF DAS WACHSTUM DES 

JENSEN-SARKOMS DER RATTE. [THE EFFECTS OF 

HYALURONIDASE AND TEM ON THE GROWTH OF JENSEN- 

SARCOMA IN RATS.] Deut. Gesundhwes., 1952, 

7: 1537-1541. Injections of hyaluronidase 

Had no influence on the growth of Jensen sar 

coma. TEM considerably inhibited tumor growth. 

Used in combination with hyaluronidase TEM 

had no effect - neither positive nor negative 

- on the tumor growth. 

3376 

Â«Marmont, A. and Fusco, F. CORREZIONE DELLA 

GRANULOCITOPENIA INDOTTA DALLA TRIETILENE- 

MELAMINA (TEM) MEDIANTE FATTORE DEL CITRO- 

VORUM (LEUCOVORIN). [CORRECTION OF TRI 

ETHYLENE MELAMINE INDUCED GRANULOCYTOPENIA 

BY CITROVORUM FACTOR.] 

1954, 69: 23-39. 

Accad. med., Tor., 

METABOLISM 

3377 

Â«Buffa, F., Vergnano, F., Resegotti, L. and 

Sartoris, S. RICERCHE SPERIMENTALI SUL 

MECCANISMO BIOCHIMICO DI AZIONE DELLA TRI 

ETILENMELAMINA. [EXPERIMENTAL STUDY OF THE 

BIOCHEMICAL ACTION OF TRIETHYLENE MELAMINE.] 

Gior. ital. chemioter., 1954, 1: 108-109. 


3: No. 2699. 

med.. Sect. 16. 1955. 

3378 

Â«Buffa, F., Vergnano, F., Resegotti, L. and 

Sartoris, S. SUL COMPORTAMENTO DI ALCUNE 

COSTANTI BIOCHIMICHE IN CORSO DI TRATTAMENTO 

CON T.E.M. [VARIATIONS IN SOME BIOCHEMICAL 

LEVELS DURING TREATMENT WITH TRIETHYLENE 

MELAMINE.] Gior. ital. chemioter., 1954, 


Sect. 16, 1955, 3J No. 3098. 

3379 

Cardinali, G., Caprino, G. and Pisciteli!, N. 

ALTÃ‰RATIONS HISTOCHIMIQUES PROVOQUÃ‰ES AU 

MOYENDE QUELQUESSUBSTANCESAMTIMITOTIQUES. 

[HISTOCHEMICALALTERATIONS INDUCEDBY MEANS 

OF SOlffi ANTIMITOTIC SUBSTANCES]. 

1955, 26: 218-220. 

Sang, Par , 

3380 

Â«Lenti, G. and Gavosto, F. SUL COMPORTAMENTO 

DELL'URICURIA IN CORSO DI TRATTAMENTO CON 

T.E.M. [VARIATIONS OF URINARY URIC ACID 

DURING TREATMENT WITH T.E.M.] Gior. ital. 

chemioter., 1954, 1_: 107-108. Abstracted 

in: Excerpta med.. Sect. 16, 1955, 3: No. 

2759.



198 

S-TRIAZINE, 2,4,6-TRIETHYLENlMINO â€”¿ METABOLISM 

(Continued) 

3381 Nadkarni, M. V., Goldenthal, E. I. and Smith, 

P. K. THE DISTRIBUTION OF RADIOACTIVITY 

FOLLOWING ADMINISTRATION OF TRIETHYLENIMINO- 

S-TRIAZINE-C14 IN TU1IOR-BEARJNG AND CONTROL 

HICE. Cancer Res., 1954, 14: 559-562. 

11 refs. 

See 

374 384 


3382 McCrea, L. E. FORMATION OF URIC ACID CALCULI 

DURING CHEMOTHERAPY FOR LEUKEMIA. J. Urol. , 

Bait., 1955, 73: 29-34. 10 refs. 

3383 

RundÃas, R. W., Coonrad, E. V. and Arenas, T. 

SERUM 

1954, 

PROTEINS IN LEUKEMIA. 

16: 842-853. 43 refs. 

Am. J. Med., 

See 

847 

RESISTANCE TO 

3384 

Jackson, H. THE DEVELOPMENT OF RESISTANCE IN 

THE WALKER CARCINOSARCOMA TO 

TRIETHYLENE MELAMINE. Brit. 

THE ACTION 

J. Cancer, 

OF 

1954, 


Ã„bstr., 1955, 49: 1198c. 

3385 

Lattanzi, A. and Pardelli, G. SULLA RESISTENZA 

PRECOCE ALLA TRIETILENMÃ‰LAMINA. [ON THE EARLY 

RESISTANCE TO TRIETHYLENE MELAMINE.] Riforma 

med., 1954, 68: 7-12. 12 refs. English 

summary. TrlFthylamine in total doses of 32- 

84 mt-was administered to 8 patients with 

leukemia over a period of 24 days. In 3 

patients following the initially successful 

therapy, a resistance to TEM treatment develop 

ed, possibly as a result of the change in the 

enzyme system of the leukemic cells. 

See 

8863Â« 

THERAPY 

3386 

Andino, A. M. de, Jr., Romero, C., Rivera, J. 

Rodriguez-Molina, 

USE OF TRIETHLENE 

R. OBSERVATIONS ON THE 

MELAMINE IN HODGKIN'S 

DISEASE. Bol. As. mea. Puerto Rico, 1953, 

45; 107-118. 6 refs. 

3387 Andrade Mejia, H. LA TRIETHYLENO-MELAMINA EN 

EL TRATAMIENTO DE LOS LINFOMAS MALIGNOS. 

[TRIETHYLENE MELAIIINE IN THE TREATMENT OF 

MALIGNANT 

26 refs. 

LYMPHOMAS.] 264 p. 

Thesis - Pontificia 

Bogota, 1955. 

Univ. CatÃ³lica 

Javeriana. 

3388 

Axelrod, A. R., Berman, L. and Murphy, R. V. 

CLINICAL AND HEMATOLOGIC EFFECTS OF TRI 

ETHYLENE MELAMINE. Am. J. Â«ed., 1953, 15: 

684-694. 51 refs. The main effects of 

treatment with TEM are reviewed and sum 

marized and experience with use of the drug 

in conditions not previously reported in 

adequate detail is presented. 

3389 Bayrd, E. D., Stickney, J. M., Hall, B. E. and 

Watkins, C. H. CLINICAL OBSERVATIONS ON THE 

USE OF TRIETHYLENEMELAMINE. Cancer, N. Y., 

1952, 5: 336-343. 4 refs. 

3390 

Black, M. M. and Speer, F. D. URETHANE PLUS 

TRIETHYLENE MELAMINE THERAPY 

CASES. N. York State J. M., 

IN HUMAN CANCER 

1954, 54: 1477- 


Sect. 16, 1955, 3: No. 1845. 

3391 

Blackburn, E. K. and King, G. M. ORAL TRI 

ETHYLENE MELAMINE THERAPY IN HUMAN NEOPLASTIC 

DISEASE. J. Fac. Radiologists, 

G: 96-103. 23 refs. Treatment 

Lo,id., 1954, 

of 24 ad 

vanced and generalized cases. 

3392 

Bock, H. E. Kirberger, E. and Woelffer, U. 

KLINISCHE ERFAHRUNGEN MIT TRrATHYLENMELAMIN 

(TEM) IN DER BEHANDLUNG VON TUMORARTIGEN 

BLUTLEIDEN. [CLINICAL EXPERIENCE IN THE 

TREATMENT OF TUMORS OF THE BLOOD WITH TEM.] 

Zschr. klin. Med.. 1953, 150: 482-498. 


Sect. 16, 1954, No. 2252. 

3393 

Bollo Monsreal, E. TRATAMIENTO DE LA ENFER 

MEDAD DE HODGKIN CON TRIETILENOMELAMINA , 

REPORTE PRELIMINAR. [TREATMENT OF HODGKIN'S 

DISEASE WITH TRIETHYLENE-MELAMINE. PRELIMIN 

ARY REPORT]. Bol. 

1953, 28: 56-62. 

Liga cancer, Habana, 

3394 

Bolton, J. H. and Bean, R. H. D. THE IMMEDIATE 

ACTION OF TRIETHYLENE MELAMINE IN CHRONIC 

LYMPHATIC LEUCHAEMIA. Med. J. Australia, 

1954, 2: 474-478. 9 refs. 

3395 

Bond, W. H., Rohn, R. J., Dyke, R. W. and Fouls, 

P. 

A. 

J. 

M. 

CLINICAL USE OF TRIETHYLENE MELAMINE. 

A. Arch. Int. M., 1953, Â£U: 602-617. 


No. 252. "Seventy-seven disease entitTes 

in 75 patients were treated..." 

3396 Bovet-Du Bois, N., Dubois-Ferriere, H., Blanc, 

W. and Vogt, A. ACTION 

TRIETHYLENE MELANINE ET 

DE LA CORTISONE, DU 

DES .QLIGO-ELÃ‰MENTS 

DANS UN CAS DE LEUCEMIE AIGUÃ‹ CHEZ L'ENFANT. 

[EFFECT OF TREATMENT WITH CORTISONE, TRI 

ETHYLENE MELANINE AND OLIGO- ELEMENTS IN A 

CASE OF ACUTE LEUKEMIA.] Praxis, Bern, 1951, 



3397 

Burtner, O. W. TRIETHYLENE MELAMINE IN THE 

TREATMENT OF LYMPHOMASAND CITHER NEOPLASTIC 

DISEASES. Ann. Int. M., 1953, 38: 1222-1244. 

11 refs. 

3398 

Colarusso, A. LA TRIETILENMELAMINA NEL TRAT 

TAMENTO DI ALCUNE EMOPATIE. [TRIETHYLENE 

MELAMINE IN THE TREATMENT 

DISEASES.] Riforma med., 

OF CERTAIN BLOOD 

1952, 66: 1071- 

1073. 9 refs. 

3399 

Di Pietro, S. L'USO DELLA TRIETILENMELAMINA 

NELLA CHEMIOTERAPIA DELLE NEOPLASIE. [USE 

OF TRIETHYLENE MELAMINE IN THE TREATMENT OF 

NEOPLASMS.] Minerva med., Tor., 1953, 44: 

585-592. 30 refs. 

3400 Ellison, R. R., Ginsberg, V. and Watson, J. 

TRIETHYLENEMELAMINE IN POLYCYTHEMIA VERA; 

A THERAPEUTIC TRIAL. Cancer, Phila., 


in: Excerpta med., Sect. 16, 1954, 2: 

No. 1746.



199 

S-TRIAZINE, 2,4,6-TRIETHYLENIMINO â€”¿ THERAPY 

(Continued) 

3401 Farber, S. EFFECT OF THERAPY ON THE LIFE HIS 

TORY AND BIOLOGIC BEHAVIOR OF LEUKEMIA. Proc. 

Inst. M. Chicago, 1951, 18: 311-325. 33 refs. 

3402 Ferrari, M. and Kasdorf, H. ENSAYOSCLÃ•NICOS 

CON TRI-ETILENO-MELAMINA(T.E.M.). [CLINICAL 

TRIALS WITH TRIETHYLENE MELAMINE.] Arch, 

urug. med., 1953, 42: 134-144. 12 refs. 

Tables. English summary. 

3403 Fisher, G. S. TRIETHYLENE MELAMINE; A CLINICAL 

NOTE. Grace Hosp. Bull., Detr., 1953, 31: 

13-16. 9 refs. Five case histories. TITe 

drug seems to have striking advantages over 

nitrogen mustard but extreme care in its 

administration is advised. 

3404 

Garciga, C. E. RESULTADO DEL TRATAMIENTO CON 

TRIETHYLENOMELAMINA EN EL MAL DE HODGKIN Y 

LEUCEMIA 

IN USING 

MIELOIDE CRONICA. 

TRIETHYLENEMELAMINE 

[RESULTS OBTAINED 

IN HODGKIN'S 

DISEASE AND CHRONIC MYELOID 

Arch, cuban, cÃ¡ncer., 1953, 

LEUKEMIA.] 

12: 39-46. 

Abstracted 

No. 324. 

in: Leukemia Abstr., 1953, 1: 

"In 5 cases of chronic myelold 

leukemia triethylenemelamine was employed 

orally in daily doses increasing from 1.25 mg. 

to 5 mg.; the treatment was interrupted as 

soon as a total of about 9,000 leukocytes 

was reached. 

never lasted 

The improvement thus obtained 

longer than 2 months..." 


3405 

Gellhorn, A., Kligerman, M. M. and Jaffe, I. 

TRIETHYLENE MELAMINE IN CLINICAL CANCER CHEMO 

THERAPY. Amer. J. Med., 1952, 13;. 428. 4 refs. 

Abstracted in: Biol. Abstr., Bait., 1954, 28: 

No. 1093. A report on the therapeutic manage 

ment of 44 cases of disseminated malignant 

disease with triethylene melamine. 

Gerhartz, H. INDIKATIONEN UND KOMPLIKATIONEN 

EINER THERAPIE DER LEUKOSEN MIT TEM. [INDI 

CATIONS AND COMPLICATIONS IN TREATMENT OF 

LEUKEMIA WITH TEM.] Verh. Deut. Ges. inn. 

Med., 1954, 60: 919-923. 

3407 

Haehner, E., Beinen, W., Loosen, H. and Schmidt, H. 

DER EINFLUSS DES TEM AUF DIE CHRONISCHE LEUKÃ„MIE, 

DIE LYMPHOGRANULOMATOSEUND DAS LYMPHOSARKOM. 

[THE EFFECT OF TEM ON CHRONIC LEUKAEMIA, LYMPHO- 

GRANULOMATOSIS AND LYMPHOSARCOMA]. 

Beri., 1954, 49: 853-856. 12 refs. 

Med. Klin., 

3408 

Â»Haga, A.L., Wasastjerna, C., Hortung, H. and 

Teir, H. TERAPIFORSÃ–K MED TRIETYLENMELAMIN. 

[THERAPEUTIC TRIAL OF TRIETHYLENEMELAMINE.] 

Fin. lak. sali, handl., 1953, 96: 151-170. 


3J No. 3183. 

3409 

Â»Hambly, C. K. and Robertson, T. I. TRIETHYLENE 

MELAMINE (TEM) IN THE TREATMENT OF MALIGNANT 

LYMPHOID DISEASE. Med. J. Australia, 1955, 

42: 900-911. 

3410 Hamerman, D. J. and Melamed, S. SOME CLINICAL 

EXPERIENCE IN THE USE OF TRIETHYLENE MELAMINE 

(TEM). J. Mount Sinai Hosp. N. York, 1953, 

20: 16-26. 29 refs. 

3411 Hansen, p. B. and Bichel, J. TRIAETYLENMELAMIN- 

BEHANDLING AT MALIGN GRANULOMATOSE OG ENKELTE 

ANDRE MALIGNE LIDELSER. [TRIETHYLENE MELAMINE 

THERAPY OF MALIGNANT ORANULOMATOSIS AND CER 

TAIN OTHER MALIGNANT DISEASES.] Nord, med., 

1952, 47: 58-61. Also in: Acta radiol., 

Stock., 1951, 36: 469-476. 9 refs. "Treatment 

with triethylene melamine resulted in good 

immediate improvement in 7 of 9 cases of 

Hodgkln's disease and in 1 of 2 cases of 

chronic lymphatic leukemia as well as 1 case 

of reticulosarcomatosis...Remissions exceeding 

5-6 months have so far only been observed in 

2 cases. In 2 cases of multiple myelomas 

and in 1 case of cancer of the breast no 

improvement was seen. The chemical and cytotoxic 

properties are closely related to the 

nitrogen mustards...The administration of 

triethylene melamine is easy; it may be given 

by mouth and has few acute side reactions." 

3412 

Heilmeyer, L. and Heilmeyer, I. TRIXTHYLEN- 

MELAMIN (TEM), EIN NEUER STOFF ZUR BEHANDLUNG 

VON LEUKÃ„MIEN. ERGEBNISSE EINER PRÃœFUNGAN 

29 FÃ„LLEN. [TRIETHYLENE MELAMINE; A NEW DRUG 

IN THE TREATMENT OF LEUKEMIA; RESULTS IN 29 

CASES]. Klin. Wschr., 1952, 30: 537-547. 

3413 

Holmes Ã Court, A. HODGKIN'S DISEASE: DIAGNOSIS 

AND TREATMENT. Med. J. Australia, 1953, 1: 

934-935. 3 refs. 

3414 

Karnofsky, D. A. TRIETHYLENE MELAMINE IN THE 

TREATMENT OF LYMPHOMAS AND LEUKEMIAS. Med. 

Clin. N. America, 1954,541^-554. 40 refs. 

A review dealing with the pharmacology, cli 

nical use, toxicity and therapeutic applica 

tions of the drug. 

3415 

Karnofsky, D. A., Burchenal, J. H., Armlstead, 

G. C., Jr., Southam, C. M., Bernstein, J. L., 

Graver, L. F. and Rhoads, C. P. TRIETHYLENE 

MELAMINE IN THE TREATMENT OF NEOPLASTIC 

DISEASE; A COMPOUND WITH NITROGEN-MUSTARD-LIKE 

ACTIVITY SUITABLE FOR ORAL AND INTRAVENOUS USE. 

A. M. A. Arch. Int. M., 1951, 87: 477-516. 

Approx. 30 refs. A report of cTinical studies. 

3416 

Karnofsky, D. A., Burcbenal, J. H., Bernstein, 

J. L. and Southam, C. M. THE ORAL USE OF 

TRIETHYLENE MELAMINE (A COMPOUND WITH NITRO 

GEN MUSTARD-LIKE ACTIVITY). Acta UniÃ³ inter 

nat, cancr., Louvain, 1953, 9: 97-100. 

8 refs. 

3417 

Kravitz, S. C., Diamond, H. D. and Craver, L. F. 

THE CLINICAL 

Blood, 1952, 

USE OF TRIETHYLENE MELAMINE. 

7: 729-742. 5 refs. 

3418 

Kravitz, S. C., Diamond, H. D. and Craver, LÂ« FÂ« 

UREMIA 

REPORT 

COMPLICATING LEUKEMIA CHEMOTHERAPY. 

OF A CASE TREATED WITH TRIETHYLENE-ME- 

LAMINE. J. Am. M. Ass., 1951, 146: 1595-1597. 

3419 

Â«Lenti, G. and Gavosto, F. RISULTATI PRATICI 

CON L'USO DEL T.E.M. NELLE AFFEZIONI NEO- 

PLASTICHE. 

[PRACTICAL 

I. NEL LINFOGRANULOMA MALIGNO. 

RESULTS WITH THE USE OF T.E.M. 

IN NEOPLASTIC DISEASES. 

LYMPHOGRANULOMATOSIS.] 

I. IN MALIGNANT 

Gior. ital. chemioter., 

1954, 1: 101-102. Abstracted in: 

Excerpta medT, Sect. 16, 1955, 3: No. 

2754. 

3420 

Â»Lenti, G. and Gavosto, F. RISULTATI PRATICI 


PLASTICHE. II. NELLE LEUCEMIE CRONICHE. 

[PRACTICAL RESULTS WITH THE USE OF T.E.M. 

IN NEOPLASTIC DISEASE. II. IN CHRONIC 

LEUKEMIA.] Gior. ital. chemioter., 1954, 


Sect. 16, 1955, 3: No. 2755.



200 

S-TRIAZINE, 2,4,6-TRIETHYLENIMINO â€”¿THERAPY 

(Continued) 

3421 



PLASTICHE. III. NEI LINFOSARCOMI E RETI - 

COLOSARCOMI. [PRACTICAL RESULTS WITH THE 

USE OF T.E.M. IN NEOPLASTIC DISEASES. III. 

IN LYMPHO- AND RETICULOSARCOMAS. ] Gior. 

ital. chemioter., 1954, ll 103-104. 

3422 



PLASTICHE. IV. NELLE NEOPLASIE POLMONARI. 

[PRACTICAL RESULTS WITH THE USE OF T.E.M. 

IN NEOPLASTIC DISEASES. IV. IN TUMORS OF 

THE LUNG.] Gior. ital. chemioter., 1954, 1: 

104-105. 

3423 

Lenti, G. and Gavosto, F. SUI RISULTATI IMMEDIATI 

DEL TRATTAMENTO CON T.E.M. DELLE AFFEZIONI NEO- 

PLASTICHE. [IMMEDIATE RESULTS OF TRIETHYLENE 

MELAMINE THERAPY OF 

Minerva med., Tor., 

NEOPLASTIC DISEASES.] 

1953, 44: pt. 2, 1-19. 

33 refs. 

34Linke, A. and Lasch, H. G. EIN BEITRAG ZUR 

CHEMOTHERAPIE DER POLYCYTHAEMIA VERA. 

[CONTRIBUTION OF THE CHEMOTHERAPY OF POLY- 

CYTHEMIA VERA.] Deut. med. Wschr., 1953, 



3425 

Linke, A. and Lasch, H. G. OBER DIE BEHANDLUNG 

VON HÃ„MOBLASTOSENMIT TRIÃ„THYLENMELAMIN (TEM). 

[TRIETHYLENE MELAMINE IN THE TREATMENT OF 

HEMOBLASTOSES]. Deut. med. Wschr., 1953, 78: 

911-915. Abstracted in: Excerpta med., SecT. 

16, 1954, 2: No. 646. 

3426 

Loeffler, R. K,, Collins, V. P. and Hyman, C. A. 

COMPARATIVE EFFECTS OF TOTAL BODY RADIATION, 

NITROGEN MUSTARD, AND TRIETHYLENE MELAMINE 

ON THE HEMATOPOIETIC SYSTEM OF TERMINAL CANCER 

PATIENTS. Science, 1953, 118; 161-163. tab. 


16, 1954, 2: No. 1711; Chem. Abstr., 1953, 47: 

11501d. 

3427 LÃ¼hrs, W. DIE CHEMOTHERAPIE DES MALIGNEN 

WACHSTUMS; VORLAUFIGER BERICHT 

BEEINFLUSSUNG VON LEUKOSEN UND 

ÃœBER DIE 

LYMPHOGRANU- 

LOMATOSEN DURCH EIN TRIAZIN-DERIVAT. [CHEMO 

THERAPY OF MALIGNANT GROWTH, PRELIMINARY RE 

PORT ON THE INFLUENCE OF A TRIAZINE DERIVA 

TIVE ON LEUKEMIA AND LYMPHOGRANULOMATOSIS.] 

Deut. Gesundhwes., 1952, 7= 1010-1019. 24 

refs. 

342U Marmont, A. and Fusco, F. LA TRIETILENEMELAMINA 

E LE SUE ASSOCIAZIONI NEL TRATTAMENTO DELLE 

EMOLÃ•NFOBLASTOSI E DI ALTRE NEOPLASIE. [TRI 

ETHYLENE MELAMINE ALONE AND ASSOCIATED WITH 

OTHER DRUGS IN THE TREATMENT OF HEMOLYMPHO- 

BLASTOSIS AND OTHER NEOPLASMS.] Gior. ital. 

chemioter., 1954, 1: 193-195. Abstracted in: 


3429 

Meyer, L. M., Sawitsky, A., Beyers, M. R., Ritz, 

N. D. and Brahin, C. TREATMENT OF CHRONIC 

LEUKEMIA WITH THIETHYLENE MELAMINE. Fed. Proc., 

Bait., 1951, 10: 324. An abstract. 

3430 Meyer, L. M., Schwartz, S. O., Sawitsky, A., 

Beyers. M. R., Ritz. N. D., Brahin, C., 

Diefenbach, W., Kleinschmidt, W. and 

Friedman, I. TREATMENT OF LYMPHOMATOUS 

DISEASES WITH TRIETHYLENE-MELAMINE. Acta 

med. scand., 1952, 144: Suppl. No. 272. 

36 p. 17 refs. Abstracted in: Chem. 

Abstr., 1953, 47: 2365h. 

3431 

Meza Arrau, C. and Nijamkin, A. RESULTADOS DEL 

EMPLEO DE LA TRIETILENMELAMINA (TEM) EN LOS 

LINFOMAS MALIGNOS Y LEUCEMIAS CRÃ“NICAS. [RE 

SULTS IN THE USE OF TRIETHYLENE MELAMINE (TEM) 

IN MALIGNANT LYMPHOMAS AND CHRONIC LEUKEMIAS.] 

Rev. med. Chile, 1955, 83: 90-95. 13 refs. 

Triethylene melamine in~Fotal individual doses 

of 10-20 mg. was administered to 23 patients 

with Hodgkin's disease and various leukemias. 

Best results were achieved in chronic lymphatic 

leukemias. 

3432 Mille. N. LIJECENJE LEUKEMIJE I LIMFOGRANULO- 

MATOZE TRIETILENMELAMINOM. [TRIETHYLENE 

MELAMINE NULOMATOSIS.] THERAPY Lijec1. OF LEUKEMIA vjes., AND 1954, LYMPHOGRA 76: 40- 

46. Abstracted in: Excerpta med., Sect. 

16, 1955, 3: No. 2760. 

3433 

Neumann, C. CYTOSTASE DURCH TRIÃ„THYLENMELAMIN 

(TEMJ BEI LYMPHOGRANULOMATOSE UND CHRONISCHEN 

LEUKÃ„MIEN. [CYTOSTASIS DUE TO TRIETHYLENE- 

MELAMINE (TEM) IN LYMPHOGRANULOMATOSIS AND 

CHRONIC LEUKEMIAS.] 

1105-1108. 10 refs. 

Klin. Wschr., 1952, 30: 

Abstracted in: Leukemia 

Abstr., 1953, 1: No. 115. "The results of 

the treatment of 3 cases of lymphogranulomatosis, 

2 cases of chronic myeloid leukemia, 

1 case of chronic lymphatic leukemia, 1 case 

of chronic lymphatic leukemia, 1 case of 

acute lymphatic leukemia and 2 cases of mye 

loma are presented. Illustrative case his 

tories are included...Though most of the 

cases showed satisfactory response, the acute 

lymphatic leukemia case and both myeloma 

were completely uninfluenced by TEM." 

cases 


3434 

Nowotna-Walcowa, R. PIERWSZE WYNIKI LECZENIA 

TROJETYLENOMELAMINA. [FIRST RESULTS OF THERA 

PY WITH TRIETHYLENE MELAMINE.] Polski 

lek., 1955, 10: 149-151. 9 refs. 

tygod. 

3435 Paterson, E. and Boland, J. TRISETHYLENEIMINO- 

S-TRIAZINE IN HUMAN MALIGNANT DISEASE: A PRE 

LIMINARY TRIAL. Brit. J. Cancer, 1951, 5: 

28-37. 1 pi. 4 refs. Abstracted in: 


Chem. Abstr., 1951, 45: 9183g. 

3436 

Paterson, E., Kunkler, P. B. and Walpole, A. L. 

TRIETHYLENEMELAMINE IN HUMAN MALIGNANT DISEASE; 

RESULTS WITH ORAL ADMINISTRATION OF ENTERIC- 

COATED TABLETS. Brit. M. J., 1953, 1: 59-64. 

Abstracted in: Excerpta med., Sect. T6, 1954, 

2: No. 198. 

3437 Pavlosky, A. and Vilaseca, G. C. LE T. E. M. 

Sang, Par., 1953, 24: 578-591. 

3438 

Polemann, G. ZUR CHEMOTHERAPIE MALIGNER ER 

KRANKUNGEN MIT 2,4,6-TRIATHYLENIMINO-S-TRIAZIN. 

[CHEMOTHERAPY OF MALIGNANCIES WITH 2,4,6-TRI- 

ETHYLENIMINO-S-TRIAZINE.] Arch. Derm. Syph., 

Beri., 1952, 194: 353-365. 17 refs. 

34?4ibilla, W. KLINISCHE ERFAHRUNGEN MIT TRI 

Ã„THYLENMELAMIN (TEM). [CLINICAL EXPERIENCES 

WITH TRIETHYLENE MELAMINE (TEM).] Deut. med. 

Wschr., 1953, 78: 95-98. 19 refs. Abstracted 

in: Excerpta mÃªU., Sect. 16, 1954, 2: No. 645. 

3440 

Pribilla, W. and Stollberg. G. TRIÃ„THYLENMELA 

MIN (TEM) BEI LYMPHATISCHEN LEUKÃ„MIEN. [TRI 

ETHYLENEMELAMINE(TEM) IN 

MÃ¼nch. ned. Wschr., 1954, 

LYMPHATIC LEUKEMIA.] 

96: 1189-1191. 

15 refs.



201 

S-TRIAZINE, 2,4,6-TRIETHYLENIMINO â€”¿ THERAPY 

(Continued) 

Rhoads, C. P., Karnofsky, D. A., Burchenal, J. H. 

and Craver, L. F. TRIETHYLENE MELAMINE IN 

THE TREATMENT OF HODGKIN'S DISEASE AND ALLIED 

NEOPLASMS. Tr. Ass. Am. Physicians, 1950, 63: 

136-146. 11 refs. 

Romeo Orbegozo, J. M. TRATAMIENTO DE LAS EN 

FERMEDADES MALIGNAS CON TRIETILENO MELANINA. 

[THERAPY OF MALIGNANT DISEASES WITH TRIETHYLENE 

MELAMINE.] Rev. clin, espaÃ±., 1953, 50: 382- 

386. Triethylene melamine in monthly doses of 

5 20 mg was administered to 75 patients with 

various malignant tumors. The size of the liver 

did not decrease and severe toxicity was ob 

served in 20 patients. The maximum doses were 

best tolerated by patients with chronic myeloid 

leukemia. 

3443 

Rosenthal, N. and Rosenthal, R. L. TREATMENT 

OF POLYCYTHEMIA VERA WITH TRIETHYLENE MELA- 

MINE; SUMMARY OF THIRTY CASES. A.H.A. Arch. 

Int. M., 1952, 90: 379-388. Approx. 13 refs. 

3444 Rotteglia, E. TEM: NUOVO CHEMIOTERAPICO NEI 

TUMORI. [TEM: A NEW CHEMOTHERAPEUTIC AGENT 

AGAINST TUMORS.] Minerva farm., Tor., 1953, 

2: 177. 4 refs. Effects of triethylene 

melamine in Hodgkin's disease and leukemia 

are surveyed. TEM was administered both 

orally (2.5-30 mg) and intravenously (1-20 

mg). The oral treatment gave better results 

especially as compared with the nitrogen 

mustard treatment. 

3445 

Ruttino, A. TRIETHYLENE MELAMINE IN THE TREAT 

MENT OF HODGKIN'S DISEASE AND OTHER LYMPHOMAS. 

N. Y. State J. M., 1952, 52: 346-348. 2 refs. 

3446 Rundles, R. W. TRIETHYLENE MELAMINE (TEM) THERAPY 

IN MALIGNANT DISEASES. GP, 1954, 9: 74-80. pi. 

3447 

Rundles, R. W. and Barton, W. B. TRIETHYLENE 

MELAMINE 

DISEASE. 

IN THE TREATMENT OF NEOPLASTIC 

Blood, Bait., 1952, 7: 483-507. 

36 refs. 

34sarasin, R. and Dubois-FerriÃ¨re, H. POSSIBILITÃ‰S 

DE TRAITEMENTS ASSOCIÃ‰S AU TRIETHYLENE-MELAMINE 

ET DE LA RADIOTHÃ‰RAPIE. [POSSIBILITIES OF COM 

BINED TREATMENT OF TRIETHYLENE MELAMINE AND 

RADIOTHERAPY.] J. beige radiol., 1951, 34: 

489-493. 

3449 Schulze, E., Franke, R. and Thiele, F. H. 

ÃœBER DIE THERAPEUTISCHE WIRKUNG VON TRIAETHYLEN- 

MELAMIN (TEM) BEI HÃ„MOBLASTOSEN. [THE THERA 

PEUTIC EFFECT OF TRIETHYLENE MELAMINE IN 

HEMOBLASTOSIS.] Aerztl. Â»sehr., 1953, 8: 690- 

694. 16 refs. 

3450 Shimkin, M. B., Bierman, H. R., Kelly, K. H., 

Lowenhaupt, E. and FÃ¼rst, A. TRISETHYLENE- 

IMINO-S-TRIAZINE (TRIETHYLENE MELAMINE OR 

TEM) IN THE TREATMENT OF NEOPLASTIC DISEASES. 

California M., 1951, 75: 26-34. 14 refs. 

34Silverberg, J. H. and Dameshek, W. USE OF TRI 

ETHYLENE MELAMINE IN TREATMENT OF LEUKEMIA 

AND LEUKOSARCOMA. J. Am. M. Ass., 1952, 148: 

1015-1021. 6 refs. Forty-six patients were 

treated. 

3452 Sokmen, C. KRONIK LÃ–SEMILERDE VE HODGKIN 

HASTALIGINDA TRIAETHYLEN MELAMINE 'TEM'. 

[TRIETHYLENE MELAMINE (TEM) IN CHRONIC 

LEUKEMIA AND HODGKIN'S DISEASE. Anadolu, 

klin., Istanbul, 1954, 20: 65-67. 8 refi 


1954, 2: No. 5072. TEM gave satisfactor; 

results' in leukemia but not in Hodgkin's 

disease. 

3453 Sykes, M. P., Rundles, R. W., Pierce, V. K. 

and Karnofsky, D. A. TRIETHYLENE MELAMINE 

IN THE MANAGEMENT OF FAR ADVANCED OVARIAN 

CANCER. Surg. Gyn. Obst., 1955, 101: 133- 

140. 6 refs. Twenty-six cases. 

3454 TRIETHYLENE-MELAMINE. Brit. M. J., 1955, 1.: 

1380-1381. 17 refs. A review. 

3455 Turco, G. L. and Lovisetto, P. SULL'AZIONE 

TERAPEUTICA DELLA T.E.M. SOMMINISTRATA PER 

VIA ENDOVENOSA. [THERAPEUTIC ACTION OF IN 

TRAVENOUS TEM.] Minerva med., Tor., 1955, 

46: 402-415. tab. 36 refs. 

3456 

Voss, C. DIE WIRKUNG VON RONTGENSTRAHLEN UND 

TRIAETHYLENMELAMIN (TEM) BEI EINEM FALL 

LYMPHOGRANULOMATOSE. [EFFECTS OF X-RAY 

VON 

AND 

TRIETHYLENE MELAMINE IN A CASE OF LYMPHOGRA- 

NULOMATOSIS.] Deut. med. J., 1955, 6: 103- 

105. 7 refs. 

Walsh, J. R., Pratt, P. T., Graham, W. E. and 

Zimmerman, H. J. TREATMENT OF LEUKEMIA AND 

LYMPHOMATA WITH TRIETHYLENE MELAMINE. Acta 

haemat., Basel, 1954, 11: 329-338. 14 refs. 

"It was...effective in patients with Hodgkin's 

disease, chronic lymphocytic leukemia, follicular 

lymphoma, polycythemia, chronic granulocytic 

leukemia and in one patient with 

bronchogenic carcinoma; it was of little or 

no value in the treatment of patients with 

acute leukemia, multiple myeloma, mycosis 

fungoides, pancreatic carcinoma and hypernephroma. 

Toxic manifestations of this agent 

have been particularly stressed..." 

3458 Wasserman, L. R. POLYCYTHEMIA VERA - ITS COURSE 

ANDTREATMENT: RELATION TOMYELOIDMETAPLASIA 

AND LEUKEMIA. Bull. N. York Acad. M.. 1954, 

30: 343 375. 53 refs. For therapy with chemotEerapeutic 

agents, see p. 361-373. 

3459 

Wilson, H. M. PRIMARY CARCINOMA OF THE LIVER: 

REPORT OF 20 CASES, INCLUDING TWO TREATED 

WITH TRIETHYLENE MELAMINE. Ann. Int. M., 

1954, Â«: 118-123. 9 refs. 

3460 Winkler, A. and Cerny, V. TRIETYLENMELAMIN V 

LIECBE LYMFOGRANULOMATÃ“ZY A HEMOBLASTÃ“Z. 

[TRIETHYLENE MELAMIN IN THE TREATMENT OF 

LYMPHOGRANULOMA AND HEMABLASTOSIS.] Cesk. 

onkol., 1954, 1: 30-38, 17 refs. English 

summary. 

3461 'Â«right, J. C., Prigot, A., Logan, M. and Hill, 

L. M. THE EFFECT OF TRI-ETHYLENE MELAMINE 

AND OF TRI-ETHYLENE PHOSPHORAMIDE IN HUMAN 

NEOPLASTIC DISEASES. Acta UniÃ³ internat, 

cancr., Louvain, 1955, !Â£: 220-257. 39 refs. 

"Favorable but temporary clinical response 

was observed in patients with Hodgkin's 

disease, lymphosarcoma, chronic myelogenous 

leukemia and chronic lymphatic leukemia under 

therapy with TEM and TEPA. Patients with 

carcinoma showed no significant improvement 

following the administration of these drugs. 

Complete remissions in some patients with 

Hodgkin's disease and lymphosarcoma have 

lasted from one to three years to date."



203 

S-TRIAZINE, 2,4,6-TRtETHYLENlMINO â€”¿ THERAPY 

(Continued) 

3462 

Wright, J. C., Prigot, A., Wright, L. T. and 

Arons, I. FURTHER OBSERVATIONS ON THE USE 

OF TRIETHYLENE MELANINE IN NEOPLASTIC DISEASES. 

A.H.A. Arch. Int. M., 1952, 89: 387-404, Ab 

stracted in: Excerpta med., Sect. 2. 1953, 6: 

No. 513. 

3463 

Wright, L. T., Wright, J. C., Prigot, A. and 

Weintraub, S. REMISSIONS CAUSED BY TRI- 

ETHYLENE MELANINE IN CERTAIN NEOPLASTIC 

DISEASES 

M. Ass., 

(A PRELIMINARY REPORT). J. Nat. 

1950, 42: 343-351. 7 reÃs. 

TOXICITY 

3465 

Cardinali, G., Pisciteli!, N. and Caprino, G. 

INTOSSICAZIONE SPERIMENTALE DA TRIETILENNELA- 

MINA. (T.E.M.) I. MODIFICAZIONI DEL QUADRO 

EMATOLOGICO. [EXPERIMENTAL TOXICITY STUDY 

WITH TRIETHYLLENE MELANINE. I. MODIFICATIONS 

OF THE BLOOD SYSTEM.] 

1953, 37: 1415-1428. 

Haematologica, Pavia, 

14 refs. English sum 

mary . 

3466 

Frumin, A. M. and Rubenstone, A. I. DERMATITIS 

DUE TO TRIETHYLENE MELANINE THERAPY. J. Am. 

M. Ass., 1953, 152: 914-915. rÃ©f. "The first 

reported instance of dermatitis due to triethylene 

melamine therapy is presented." 

3467 

Husebye, K. O. KIDNEYS IN TREATED AND UNTREATED 

LEUKEMIA. Rochester, Minn,, 

Thesis - Univ. of Ninnesota. 

1954. 106 t 

11 pi. 106 refs. 

Typewritten. 

3468 

Kraus, S. D., Weintraub, S. and Wright, L. T. 

ACTION OF TRIETHYLENEMELAMINE 

Soc. Exp. Biol., N. Y., 1951, 

IN NICE. Proc. 

71: 489-493. 

tab. 12 refs. Abstracted in:TTxcerpta med., 

Sect. 2, 1951, 4: No. 6180; Chem. Abstr., 

1951, 45: 6295e7 

3469 Nartin, H. TÃ–DLICHE URANIE NACH TRIATHYLENHELA- 

NIN-BEHANDLUNG BEI EINER CHRONISCHEN LYMPHA 

TISCHEN LEUKÃ„MIE. [FATAL UREMIA AFTER TRI 

ETHYLENEMELAMINE TREATMENT IN CHRONIC LYMPHATIC 

LEUKEMIA.] Klin. Wschr., 1953, 31: 263-266. 

13 refs. 

3470 

Philips, T. S., Thiersch, J. B., Wheelock, B. 

and Borgatta, M. THE NITROGEN MUSTARD-LIKE 

ACTIONS OF 2,4,6-TRIS(ETHYLENININO)-S-TRIA- 

ZINE 

Exp. 

AND OTHER BIS(ETHYLENININES). J. Pharm. 

Ther., 1950, 100: 398-407. 20 refs. 

3471 Riegel. R. and KrÃ¼ckemeyer, K. SCHÃ„DIGUNG DES 

HAEMATOPOETISCHEN SYSTENS NACH BEHANDLUNG MIT 

TRIAETHYLENIMINOTRIAZIN (TEM) BEI EINEM FALL 

VON BRILL-SYMNERSSCHER ERKRANKUNG. [INJURY 

TO THE HENATOPOIETIC SYSTEN AFTER TREATNENT 

WITH TRIETHYLENE IMINOTRIAZINE (TEN) IN A 

CASE OF BRILL-SYMMERS DISEASE.] Deut. med. 

J., 1954, 5: 207-211. 

3472 

Â«Sforzini, P. INTERVENTO DELL'STH NELLE TERAPIE 

CON ANTINITOTICI. [EFFECT OF SONATOTROPHIC 

HORMONE DURING THERAPY WITH ANTINITOTICS.] 

Gior. ital. chemioter., 1954, 1: 143-145. tab. 


3: No. 2262. 

3473 

Slipyan, A. UNUSUAL TOXICITY TO TRIETHYLENE 

MELAMINE IN A CASE OF CHRONIC MYELOGENOUS 

LEUKEMIA. Ann. Int. M., 1953, 38: 331-335. 

14 refs. A severe fatal bone marrow de 

pression developed after administration of 

a very small dose of triethylene melamine. 

3464 

3474 

Yanguas, M. G. TRIETHYLENE MELANINE (TEH) IN 

Turco, G. L. and Lovisetto, P. STUDIO QUANTI 

THE TREATMENT OF MALIGNANCIES, WITH SPECIAL 

TATIVO SULLA RIPRESA LEUCOCITARIA NELL'UOMO 

REFERENCE TO LYMPHOMATA. Acta UniÃ³ internat, 

DOPO UNA INIBIZIONE LEUCOPENIZZANTE DA TRIcancr., 

Louvain, 1955, 11: 258-259. 

ETILENMELAMINA. [QUANTITATIVE STUDIES ON 

LEUKOCYTIC REPRESSION IN MAN FOLLOWING LEU- 

KOPENIC INHIBITION WITH TRIETHYLENE MELANINE l 

Farmaco, ed. se., Pavia, 1955, 10: 135-143. 

37512521832204523252463257453415511833211723762470263157315621835228223842490118515762032230823902497 

1208 

rÃ©f. English summary. 

1831 

2036 

See 

2314 

2438 

2107 240Â« 3423 3428 3454 

2561 

S-TRIAZINES 

3475 

Hofferber, 0. and Scholz, I. KLINISCHE UND HÃ„- 

MATOLOGISCHE BEOBACHTUNGEN ÃœBER DIE WIRKUNG 

DES TRIAZINDERIVATES TRIAMELIN (TEM-HÃ– 193) 

AUF DIE LYNPHADENOSE DES RINDES. [CLINICAL 

AND HEMATOLOGICAL OBSERVATIONS ON THE EFFECT 

OF A TRIAZINE DERIVATIVE, TRIANELIN (TEM-HÃ– 

193) ON THE LYNPHADENOMA IN CATTLE.] 

Mhefte vet. Ned., 1953. 8: 563-569. 10 refs 

Triamelin in doses of O.O5-0.1 mg was given 

subcutaneously and orally to one normal bull, 

one normal mare and 5 cows with lymphadenomas. 

In the normal animals triamelin decreased 

the leucocyte count; in the cows the drug 

normalized the blood picture and favorably 

affected the lymphadenoma, without affecting 

the milk production. 

3476 

Rose, F. L., Hendry, J. A. and Walpole, A. L. 

NEW CYTOTOXIC AGENTS WITH TUMOUR-INHIBITORY 

ACTIVITY. Nature, Lond., 1950, 165: 993-993. 

10 refs. 

See 

1911 2649 335Â« 3470 

lH-v-TRIAZOLO[d]PYRIMIDINE, 5-AMNO-7-HYDROXY- 

3477 

Paolino, W. CHEMIOTERAPIA DEI TUMORI; ANTAGO 

NISTI 

NICI. 

PER ANALOGIA: ANTIFOLICI ED ANTIPURI- 

[CHEMOTHERAPY OF TUMOURS: FOLIC ACID 

AND FURINE ANTAGONISTS.] Minerva med., Tor., 

1954, 45: pt. 1, 26-44. 204 refs. A biblio 

graphical review. 


3478 

Arons, I., Weintraub, S., Sokoloff, B. and 

Dutcher, R. METABOLITE ANTAGONISTS IN 

CANCER; GUANAZOLO. Acta UniÃ³ internat, 

Experiments 

cancr., Louvain, 

with August~rat 

1951, 7: 427-431. 

carcinoma 

S 

did 

refs. 

not bear out the assumption of Kidder and 

others that cancerous cells differ from 

normal cells in their capacity to metabolize 

guanine. 'The fact that the inhibition pro 

duced by guanazolo on certain types of car 

cinoma is evidenced only when the transplant 

is very young, one to five days old, and 

that there is a slight, if any, inhibitive 

effect when the tumor reaches its active 

stage makes this theory untenable."



203 

lH-v-TRIAZOLO[d]PYRIMIDINE, 5-AMINO-7-HYDROXY-, 

â€”¿EFFECT ON MALIGNANT GROWTH (Continued) 

3479 

Carpender, J. w,, J. and Lauter, R. R. THE COM 

BINED EFFECT OF A TUMOR INHIBITOR (5-AMINO-7- 

HYDROXY-1 H-V-TRIAZOLO [D] PYRIMIDINE) AND 

X-RAY THERAPY. Radiology, 1950, 55: 874-878. 


45: 2580e ; Biol. Abstr., Bait., 1951, 25: 

So. 27883. 

3480 Finkelstein, If. and Thomas, P. A. STUDIES ON 

THE EFFECT OF 8-AZAGUANINE ON SARCOMA 37 IN 

MICE. 

1 pi. 

Cancer Res., 1951, 11: 801-806. 

16 refs. AbstracteS~in: Excerpta 

med., Sect. 5, 1952. 

single large dose of 

5: No. 1945. 

8-azaguanine 

After a 

gross tumor 

damage occurred in 2-6 hours and extensive 

morphological damage in 24 hours; multiple 

doses produced a definite inhibition of 

growth and marked cellular damage of the 

sarcoma. The mitotic figures in tumors 

approached that of controls after multiple 

doses but decreased to 1/5 that of controls 

after a single large dose. 

was similar in control and 

Toxic acticn 

tumor-bearing 

animals. 

3481 

Flint, T. J., Hirschberg, E. and Murray, M. R. 

COMPARATIVE EFFECTS OF CHEMOTHERAPEUTIC 

ON BROWN-PEARCE TUMOR AND NORMAL RABBIT 

AGENTS 

TESTIS 

IN VITRO. Proc. Soc. Exp. Biol., N. Y., 1953, 

84: 493-496. 10 refs. 

3482 

Gellhorn, A. LABORATORY AND CLINICAL STUDIES 

ON 8-AZAGUANINE. Cancer, Phila., 1953, 6: 



Abstr., 1954, 48: 889a. 

3483 Gellhorn, A., Engelman, M., Shapiro, D., Graff, S. 

and Gillespie, H. THE EFFECT OF 5-AMINO-7-HYDROXY- 

1H-V-TRIAZOLO (D) PYRIMIDINE (GUANAZOLO) ON A 

VARIETY OF NEOPLASMS IN EXPERIMENTAL ANIMALS. 


Abstracted in: Chem. Abstr., 1950, 44: No. 5477e. 

"...guanazolo, inhibited 3 transplaÃ±Table 

adenocarcinomas of the breast in mice, and an 

undif ferentiated squamous cell carcinoma trans 

planted into the rabbit's eye. It did not in 

hibit an undifferentiated sarcoma, leukemia, 

or lymphosarcoma in mice. No significant toxic 

effect, as indicated by wt. loss, occurred as a 

result of guanazolo administration." -Chem. Abstr. 

3484 Law, L. W. STUDIES ON THE EFFECTS OF A GUANI NE 

ANALOG ON ACUTE LYMPHOID LEUKEMIAS OF MICE. 

Cancer Res., 1950, 1Â£: 186-190. 9 refs. 

Parenteral administration of guanazolo pro 

duced a definite, regular, and reproducible 

inhibition of two transplantable acute lymphoid 

leukemias in mice but had no effect 

on a transplantable lymphosarcoma. The in 

hibition was released by use of guanine hydrochloride. 

Mandel, H. G., Alpen, E. L., Winters, W. D. 

and Smith, P. K. THE URINARY METABOLITES OF 

8-AZAGUANINE IN THE MOUSE AND THE MONKEY. 



5: No. 4019. 

3486 Meyer, J. and Weinmann. J. P. THE EFFECT OF 

PROLONGED ADMINISTRATION OF 8-AZAGUANINE ON 

THE GROWTH OF TRANSPLANTED ADE NOC ARC INOM A 

E 0771. Cancer Res., 1951, 11.: 914-917. 


5, 1952, 5: No. 2388. 

3487 Shapiro, D. M. COMBINATION CHEMOTHERAPY OF 

CANCER BASED UPON QUANTITATIVE BIOCHEMICAL 

DIFFERENCES. Surg. Forum, 1955, 5: 646-650. 

8 refs. 

3488 

Shiba, S., Kimoto, S., Kushima, K , Imamura, H. 

and Kawai, A. EFFECT OF 8-AZAGUANINE ON 

MALIGNANT TUMOR. Gann, Tokyo, 1954, 45: 471- 


3489 

Shapiro, D. M., Weiss, R. and Gellhorn, A. 

THE EFFECT OF AZAGUANINE ON MITOSIS IN 

NORMAL 

N. Y., 

AND NEOPLASTIC TISSUES. Cancer, 

1950, 3: 896-902. 6 refs. 


10932b. 

3490 

Sokoloff, B., Redd, J. B. and Dutcher, R. 

METABOLITE ANTAGONISTS IN EXPERIMENTAL 

CANCER:GUANAZOLO.A.M.A.Arch,path., 

1950, 50: 411-418. 10 refs. Action of 

guanazÃTo on 

investigated 

August rat carcinoma was 

in a series' of 4 experiments. 

Compare with: Sokoloff, Redd, Dutcher. 

Fed. Proc., Bait., 1950. 

3491 

Sugiura, K., Hitchings, G. H., Cavalieri, L. F. 

and Stock, C. C. THE EFFECT OF 8-AZAGUANINE 

ON THE GROWTH OF CARCINOMA, SARCOMA, OSTEO- 

GENIC SARCOMA, LYMPHOSARCOMA, AND MELANOMA 

IN ANIMALS. Cancer Res., 1950, 10: 178-185. 

11 refs. Abstracted in; Chem. ABstr., 1950, 

44: 6953e. 

3492 

Woodside, G. L., Kidder, G. W., Dewey, V. C. and 

Parks, R. E., Jr. THE INFLUENCE OF 8-AZAGUA 

NINE ON THE MITOTIC RATE AND HISTOLOGICAL 

APPEARANCE OF CERTAIN NORMAL AND NEOPLASTIC 

TISSUES. Cancer Res., 1953, 13: 289-293. pi. 

10 refs. 

3493 

Yamaguchi, H., Terashita, N., Shibata, K., 

Kurahori, T., Kalo, s. and Yoshimura, Y. 

EFFECT OF GUANAZOLO AND ITS DERIVATIVES ON 

YOSHIDA SARCOMA. I. Gann, Tokyo, 1954, 

45: 475-477. In Japanese. 

See 

235 

3507 

EFFECT 

1722 

3510 

1919 

3531 


2884 2887 

3494 

Cooperman, B. and Howes, E. L. INFLUENCE OF 

TRIAZOLOPYRIMIDINE ON FIBROPLASIA AND EPI- 

THELIZATION. 105-109. 9 refs. Surg. Gyn. Obst., 1951, â€”¿' 92- 

3495 

Meyer, J., Henry, J. L. and Weinmann, J. P. 

THE EFFECT OF 8-AZAGUANINE ON PHYSIOLOGIC 

GROWTH MEASURED BY THE RATE OF ERUPTION OF 

THE INCISOR OF THE MOUSE. 

1951, 11: 437-441. 3 refs. 

Cancer Res 


Chem. Xbstr., 1951, 45: 9739a. 

EFFECT ON TUMOR GROWTH IN PLANTS 

1024 1335



204 

lH-v-TRlAZOLO[d]PYRIMIDINE, 5-AMINO-7-HYDROXY 

â€”¿ EFFECTS. COUNTERACTION TO 

3496 

Gellhorn, A., Hirschberg, E. and Keils, A. THE 

EFFECT OF PURINES, NUCLEOSIDES, AND NUCLEOTIDES 

ON THE CARCINOSTATIC ACTION OF 8-AZAGUANINE. 


27 refs. 

16, 1954, 

Abstracted in: Exci?pta med., Sect. 

2: No. 2145. "The carcinostatic 

activity oÃ 8-azaguanine (25 mg per kg of 

body weight) against the Brown-Pearce carci 

noma, growing in the anterior chamber of the 

rabbit eye, was significantly decreased by 

the simultaneous administration of adenylic 

acid, adenosine, adenine, guanylic acid, and 

guanosine(200 mg per kg each). Guanine(200 

mg per kg) did not only decrease the carcino 

static activity of 8-azaguanine against 

this tumour, 

tiate it." 

but actually appeared to poten 

3497 

Kidder, G. W., Dewey, V. C. and Parks, R. E., 

Jr. EFFECT OF LOWERED ESSENTIAL METABOLITES 

ON 8-AZAGUANINE INHIBITION. J. Biol. Chem., 

1952, 197: 193-198. 14 refs. 

See 

3518 EFFECTS, 3520ENHANCEMENT 

3498 

Dietrich, L. S. and Shapiro, D. M.. COMBINATION 

CHEMOTHERAPYOF CANCER: POTENTIATION OF CAR 

CINOSTATIC ACTION OF 8-AZAGUANINEBY A RIBO- 

FLAVIN ANALOG. Cancer Res., 1953, 13: 


699- 

med., 

Sect. 5, 1954, 7: No. 884. 

3499 

Mandel, H. G. and Law, L. W. THE EFFECT OF 4- 

AMINO-5-IMIDAZOLECARBOXAMIDEON THE CARCINO 

STATIC ACTION OF 8-AZAGUANINE. Cancer Res., 

1954, 14: 808-811. 14 refs. 

35UU 

Shapiro, D. M. and Gellhorn, A. COMBINATIONS 

OF CHEMICAL COMPOUNDS IN EXPERIMENTAL CANCER 

THERAPY. Cancer Res., 1951, 11: 35-41. 

3501 

Shapiro, D. M., Kream, J. and Dietrich, L. S. 

COMBINATION CHEMOTHERAPY OF CANCER: POTENTIA 

TION OF CARCINOSTATIC 

BY 6-FORMYLPTERIDINE. 

ACTIVITY OF 

Proc. Soc. 

8-AZAGUANINE 

Exp. Biol., 

N. Y., 1952, 8^: 616-619. 8 refs. Abstracted 


"2-Amino-4-hydroxy-6-formylpteridine~. ..al 

555. 

See 

though noncarcinostatic by itself, augmented 

the carcinostatic action of 8-azaguanine... 

against a mammary adenocarcinoma,.." 

1341 1785 

METABOLISM (INCLUDING EFFECTS 

PROCESSES) 

ON METABOLIC 

3502 Bennett, L. L., Jr., Skipper, H. E., Mitchell, 

J. H,, Jr. and Sugiura, K. STUDIES ON THE 

DISTRIBUTION OF RADIOACTIVE 8-AZAGUANINE 

(GUANAZOLO)IN MICE WITH E0771 TUMORS. 


3503 

Carlo, P. E. and Mandel, H. G. THE EFFECT OF 

AZAGUANINE ON THE INCORPORATION OF GUANINE 

AND OF 4-AMINO-5-IMIDAZOLECARBOXAMIDE INTO 

TUMOR-BEARING MICE. J. Biol. Chem., 1953, 


Excerpta med., Sect. 16, 1954, 

Chem. Abstr., 1953, 47: 82381. 

2: No. 

~ 

557; 

3504 

Creaser, E. H. EFFECT OF 8-AZAGUANINE ON ENZYME 

FORMATION. Nature, Lond., 1955, 176: 556-557 

4 refs. 

3505 

Finkelstein, M., Winters, W. D., Thomas, P. A., 

Davison, C. and Smith, 

8-AZAGUANINE ON TISSUE 

P. K. THE 

METABOLISM 

EFFECT OF 

IN MICE 

BEARING SARCOMA 37. 

807-810. 11 refs. 


When added to tissueâ€” 

slices, 8-Azaguanine had no effect. 

compound "showed a selective action 

The 

on tumor 

tissue after parenteral administration. The 

minimal effective dose was 200 mg/ kg. Two 

hours after a single dose of 500 mg/ kg there 

was a significant inhibition of respiration, 

which became almost complete 

Forty-eight hours after drug 

after 24 hours. 

administration, 

the effect on tumor respiration was diminished.1 

Administration of guanine did not reverse the 

action of 8-azaguanine. 

3506 

Flavin. M. and Engelman, M. AMINOPURINE INTER- 

CONVERSION IN TETRAHYMENA GELEII: ROLE OF 

8-AZAGUANINE AND HYPOXANTHINE. J. Biol. Chem., 


Chem. Ã•Bstr., 1953, 47: No. 4001b. 

3507 

Graff, S. SOME OBSERVATIONS ON THE NUCLEIC 

ACIDS. J. Mount Sinai 

19: 313-319. 15 refs. 

Hosp. N. York, 1952, 

3508 

Graff, S., Engleman, M. and Graff, A. M. EX 

PERIMENTS ON THE NUCLEIC ACIDS. Acta UniÃ³ 

internat, 

"A number 

cancr., Louvain, 1951, 7: 463-465. 

of analogs of guanine have been 

synthetized and found to lack the carcino 

static properties peculiar to guanozolo 

(Kidder). Inhibitions of cancer prolifera 

tion by guanozolo is not reflected in the 

incorporation of glycine or adenine by the 

total nucleic acids of cancer tissues. 

These experiments 

static properties 

indicate that the carcino 

of guanozolo do not in 

volve competitive inhibition with guanine." 

3509 

Hirschberg, 

ENZYMATIC 

E., Kream, J. and Gellhorn, 

DEAMINATION OF 8-AZAGUANINE 

A. 

IN NOR 

MAL AND NEOPLASTIC TISSUES. Cancer Res., 

1952, 12: 524-528. 19 refs. 

Excerpta" med., Sect. 2, 1953, 


6: No. 2629; 

Chem. Abstr., 1952, 46: No. 103~97g. 

3510 

Hirschberg, E., Murray, M. R., Peterson, E. R., 

Kream, J., Schafranek, 

ENZYMIC DEAMINATION OF 

R. and Pool, 

8-AZAGUANINE 

J. L. 

IN NORMAL 

HUMAN BRAIN AND IN GLIOBLASTOMA MULTIFORME. 


Abstracted in: Chem. Abstr., 1953, 47: 6530d; 

Excerpta med., Sect. 16, 1954, 2: NOT 102. 

3511 

Kidder, G. W., Dewey, V. C., Parks, H. E., Jr. 

and Woodside, G. L. PURINE METABOLISM OF 

TETRAHYMENA AND ITS RELATION TO MALIGNANT 

CELLS IN MICE. Science, 1949, 109: 511-514. 

19 refs. Abstracted in: Biol. ATSstr., Bait., 

1950, 24: No. 4100; Excerpta med., Sect. 5, 

1950, 37 No. 3855. Guanazolo inhibited the 

growth of transplanted adenocarcinoma, spon 

taneous mammary cancer, and lymphoid leuke 

mia in mice. Diaminazolo does not inhibit 

neoplastic growth. Both agents inhibit 

growth of Tetrahymena. 

3512 

Kondo, T. and Maruyama, T. DIE ENZYMATISCHE 

DESAMINATION DES 8-AZAGUANINS DURCH DEN 

RATTEN-GESCHWULST-ASZITES. [ENZYMATIC DE 

AMINATION OF 8-AZAGUANINE BY ASCITES TUMORS 

IN RATS.] Gann, Tokyo, 1954, 45: 477-479.



205 

lH-v-TPlAZOLO[d]oYRIMIDINE, 5-AMINO-7-HYDROXY 

â€”¿METABOLISM (INCLUDING EFFECTS ON METABOLIC 

PROCESSES) (Continued) 

3513 

Handel, H.,G., Carlo, P. Â£. and Smith, P. K. 

THE INCORPORATION OF 8-AZAGUANINE INTO NUCLEIC 

ACIDS OF TUMOR-BEARING MICE. J. Biol. Chem., 

1954, 206: 181-189. 14 reÃs. 

3514 

Mitchell, J. H., Jr., Skipper, H. E. and Bennett, 

L. L. INVESTIGATION OF THE NUCLEIC ACIDS OF 

VISCERA AND TUMOR TISSUE FROM ANIMALS INJECTED 

WITH RADIOACTIVE 8-AZAGUANINE. Cancer Res., 

1950, 10: 647-649. 11 refs. 

3515 

Â»Norris, E. R. and Roush, A. THE COMPETITIVE 

INHIBITION OF URICASE ACTIVITY BY 8-AZAGUA 

NINE AND BY 8-AZAXANTHINE. Arch. Biochera., 

N. -Y., 1950, 28: 465-466. Abstracted in: 

Chem. Abstr.,~T951, 45: 3004g. 

3516 Parks, R. E. ANTIMETABOLITE STUDIES IN TETRA- 

HYMENA AND TUMORS. In: Antimetabolites and 

cancer. (Rhoads, C. P., ed.) Washington, 

Am. Ass. Advanc. So., 1955, 175-197. Biblio 

graphy: p. 195-197. 

3517 Roush, A. and Norris, E. R. DEAMINATION OF 

8-AZAGUANINE BY GUANASE. Arch. Biochem., 

N. Y., 1950, 29: 124-129. 

384 1348 3482 


3518 

Goldin, A., Greenspan, E. M. and Schoenbach, 

E. B. STUDIES ON THE MECHANISM OF ACTION 

OF CHEMOTHERAPEUTIC AGENTS IN CANCER. IV. 

RELATIONSHIP OF GUANINE AND GUANYLIC ACID 

TO THE ACTION OF GUANAZOLO ON LYMPHOID TU 

MORS IN MICE 

Inst., 1950, 

AND RATS. J. Nat. Cancer 

1_1: 319-338. 23 refs. 

3519 

Kidder, G. W., Dewey, V. C., Parks, R. E., Jr. 

and Woodside, G. L. FURTHER EVIDENCE ON THE 

MODE OF ACTION OF 8-AZAGUANINE (GUANAZOLO) 

IN TUMOR INHIBITION. Cancer Res., 1951, 11.: 


Abstr., 

Sect. 5, 

1951, 

1951,"?: 

45: No. 

No. 

9738e; 

3123. 

Excerpta med. , 

See 

1635 

- PHARMACOLOGICAL AND PHYSIOLOGICAL EFFECTS 

3520 Malgren, R. A., Bennison, B. E. and McKinley, 

T. W. EFFECT OF GUANAZOLO ON ANTIBODY FOR 

MATION. J. Nat. Cancer Inst., 1952, 12: 

807-818. 22 refs. 

- RESISTANCE TO 

See 

2687 

â€”¿TOXICITY 

3523 

Armistead, G. C., Jr., Burchenal, J. H., 

Karnofsky, D. A. and Southam, C. M. PRE 

LIMINARY STUDIES ON THE CLINICAL TOXICITY OF 

5-AMINO-7-HYDROXY-I-V-TRIAZOLO [D]-PYRIMIDINE 

(GUANAZOLO). Cancer, N. Y., 1949, 2: 1087- 

1088. 4 refs. Abstracted in: Excerpta ned., 

Sect. 5, 1950, 3: No. 3533. 

3524 

Carlo, P. E. and Handel, H. G. THE EFFECT OF 

4-AMINO-5-IMIDAZOLECARBOXAMIDE ON THE TOXI 

CITY OF 8-AZAGUANINE. Cancer Res., 1954, 

1Â£: 459-462. 13 refs. 


3525 

Colsky, J., Greenspan, E. M. and Schoenbach, E. B. 

OBSERVATIONS ON THE EFFECTS OF ADMINISTRATION 

OF GUANAZOLO IN PATIENTS WITH DISSEMINATED 

NEOPLASMS. Cancer, N. Y., 1952, 5: 1221-4. 

Abstracted in: Chem. Abstr., 1953, 47: No. 238uc; 

Leukemia abstr., 1953, 1: No. 50. 

3526 

Colsky, J., Meiselas, L. E., Rosen, S. J. and 

Schulman, I. RESPONSE 

KEMIA TO 8-AZAGUANINE. 

OF PATIENTS WITH LEU 

Blood, Bait., 1955, 

U>: 482-492. 32 refs. 

3527 

Kondo, T., Tanaka, Y., Ito, T. and Isomura, N. 

PULMONARY CANCER TREATED WITH 8-AZAGUANINE 


3528 

Shiba, S., Kushima, K., Imamura, H. and Kawai, 

A. EFFECT OF FURINE ANTAGONIST (8-AZAGUANINE) 

ON MALIGNANT TUMOR. Gann, 


Tokyo, 1953, 44: 

3529 

Straus, B., Berson, S., Bernstein, T. and 

Jacobson, 

HODGKIN'S 

A. S. GUANAZOLO 

DISEASE. Blood, 

IN THE 

Bait., 

THERAPY OF 

1950, 5: 

1059-1061. 5 refs. No therapeutic effect 

was observed. Toxic manifestations were 

pain and tenderness at the site of injection. 

No inhibition of growth was observed when 

the effect of guanazolo was tested on tissue 

cultures of an involved node. 

3530 

Yamamoto, S., Yamada, T., Nagata, H. and Tejima, 

K. 8-AZAGUANINE IN THE THERAPY OF GYNECOLOGIC 

MALIGNANT TUMORS. Gann, Tokyo, 1953, 44: 350- 


See 

3521 

Law, L. W. RESISTANCE IN LEUKEMIC CELLS TO A 

GUANINE ANALOG, 8-AZAGUANINE. Proc. Soc . Exp. 

Biol., N. Y., 1951, 78; 499-502. 18 refs. 

"The development of resistance in a transplantable 

acute lymphocytic leukemia 

mouse to 8-azaguanine is reported." 

of the 

The 

azaguanine-resistant cells showed no resis 

tance to amethopterin and TEM. 

1431 

l-H-v-TRIAZOLO[d]PYRIMIDINE, 

See 

3519 

TRIAZOLO 

PYRIMIDINES 

7-AMINO- 

3522 Skipper, H. E. MECHANISM OF DRUG RESISTANCE 

TO METABOLITE ANTAGONISTS IN NEOPLASTIC 

CELLS. 

(Rhoads,~C. 

In: Antimetabolites 

P., ed.) Â»ashington, 

and cancer. 

Am. Ass. 

Advanc. Sc., 1955, 219-230. 23 refs. 

3531 

Stock, C. C., Cavalieri, L. F., Hitchings, G. H. 

and Buckley, S. M. A TEST OF TRIAZOLOPYRIMI- 

DINES ON MOUSE SARCOMA 180. Proc. Soc. Exp. 

Biol., N. Y., 1949, 72: 565-567. Abstracted 

in: Chem. Abstr., 195Ãœ, 44: 3611a.



206 

TROPOLONE 

COMPOUNDS 

3532 

Â«Katsura, S., Sat8, K., Akaishi, K., Nozoe, T., 

Seto, 3. and Kitahara, Y. EFFECT OF TROPO 

LONE AND RELATED COMPOUNDS ON YOSHIDA SAR 

COMA I. Proc. Japan Acad., 1951, 27: 31-35. 

In English. Abstracted in: Chem. Ã•Bstr., 

1952, 4J5: 11460e. 

3533 Sato K EFFECTS OF 46 COMPOUNDS HAVING UNSATU- 

RATED SEVEN-MEMBERED RING STRUCTURES ON YOSHIDA 

SARCOMA. Tohoku Igaku zassi, 1954, 49: 18-24. 

12 refs. Abstracted in: Chen. Abstr., 1954, 

48: 5366b. 

3534 Sato, K. and Akaishi, K. EFFECT OF 

TROPOLONE AND RELATED COMPOUNDS (COM 

POUNDS HAVING UNSATURATED SEVEN MEMBERED 

RING STRUCTURE) ON YOSHIDA SARCOMA. Gann, 

Tokyo, 1951, 42:147-149. 

See 

Sato, K., Akaishi, K., Kawamura, K. and Nakamura, 

Y EFFECT OF TROPOLONE AND ALLIED COMPOUNDS 

ON YOSHIDA SARCOMA. II. Gann, Tokyo, 1953, 

44-350357. In English. 5-aminotropolone, 

t?opolone methylether, 5-aminotropolone diacc 

iate 5-amino-7-bromotropolone diacciate, N- 

acetyl-5-aminotropolone and 4-aminomethyltropolone 

in doses of 20-40 mg Â«ere administered 

intraperitoneally to rats with Yoshida sarcoma. 

The 5 compounds effected the tumor cells mor 

phologically "but the ratio between the M.T.D. 

and the M.E.D. to Yoshida sarcoma cells, when 

these compounds are used, is lower than colchicine." 

254 

TUMOR EXÃšDATES 

see TISSUE EXTRACTS, 

TRYPAN BLUE, 

LEAD 

TUMOR 

3536 Bursell, S. THERAPEUTICAL INVESTIGATIONS ON 

INDUCED CANCER IN MICE. EFFECTS OF THE 

TREATMENT WITH LEAD TRYPAN BLUE, THORIUM 

TRYPAN BLUE, AND CASTRATION ON CANCER IN 

DUCED BY TAR AND DIBENZPYRENE. Upsala 

lak. foren. forh., 1948, 53j 95-205. 

Bibliography: p. 197-205. Abstracted in: 

Biol. Abstr., Bait., 1949, 23: No. 26531. 

"The treatment of tumor bearTng mice with 

lead trypan blue brought about a statis 

tically significant inhibition of the 

growth of tumors in both males and females. 

MÃ©tastases were also inhibited. Thorium 

trypan blue also inhibited tumor growth in 

both males and females but inhibited mÃ© 

tastases only in females. Thorium trypan 

blue also increased the longevity of tumorbearing 

animals." - Biol. Abstr. 

See 

1944 

TRYPANOSOMA CRUZI - EFFECT ON TUMOR GROWTH 

3537 Commoner, B. KR, NE* RUSSIAN ADVANCE IN CANCER 

RESEARCH. Sc. Illusi., N. Y., 1946, ^Ã® No. 9, 

32, 87-88. Injections of Trypanosoma Cruzi 

into 45 mice Â»ith transplanted tumors prevent 

ed tumor growth in 15, and caused regression 

of growth in 30. The serum retains its poten 

cy for 10-12 days, depending on the dosage. 

The serum has been 90% successful in over 

13,000 mice with experimental cancers. 

3538 

Coudert, J. and Juttin, P. NOTE SUR L'ACTION 

D'UN LYSAT DE TRYPANOSOMA CRUZI VIS-A-VIS 

D'UN CANCER GREFFE DU RAT. [ACTION OF A 

LYSATE OF TRYPANOSOMA CRUZI ON GRAFTED CAN 

CER IN RATS.] C. rend. Soc. biol., 1950, 

144: 847-849. Abstracted in: Chem. Abstr., 

1951, 45: 1677b; Index analyt. cancer., 

Par., T551, 22: No. 542. "A lysate (method 

of preparation not stated) oÃ the washed 

organisms, injected in another part of the 

body from the tumor, caused significant re 

gression of the tumors." - Chem. Abstr. 

3539 

Gruhzit, O. M. and Fisken, R. A. FAILURE OF 

TRYPANOSOMA CRUZI LYSATE IN TREATMENT OF 

BROWN-PIERCE CARCINOMA OF RABBIT. Fed. Proc., 

Bait., no inhibitory~effect 1948, 7j 271. on Trypanosoma the growth cruzi of Brown- had 

Pierce 

carcinoma. 

3540 

Hauschka, T. S. and Goodwin, M. B. IL TRYPANO 

SOMA CRUZI (ENDOTOSSINA KR) NELLA CURA DEI TUMORI 

MALIGNI SPERIMENTALI, NEI TOPI. [TRYPANOSOMA 

CRUZI (ENDOTOXIN KR) IN THE TREATMENT OF EXPERI 

MENTAL MALIGNANT TUMORS OF THE MOUSE.] Medico 

condotto, 1948, 46: No. 3, 74-77. 8 refs. This 

is essentially th"e same as the report in: 

Science, 1948, 107: 600-602. 

3541 

Hauschka, T. S. and Goodwin, M. B. TRYPANOSOMA 

CRUZI ENDOTOXIN (KR) IN THE TREATMENT OF 

MALIGNANT 

600-602. 

MOUSE TUMORS. Science, 1948, 107: 

8 refs. '"Whole culture lysates' 

tested...against spontaneous adenocarcinoma 

in 40 C3H and dba-mice gave no sign of cancerolytic 

vival." 

effect and did not prolong sur 

3542 Hauschka, T., Saxe, L. H. Jr., Blair, M., 

Tower. N. M. and Palmquist, J. TRYPANOSOMA 

CRUZI IN THE TREATMENT OF MOUSE TUMORS. 

J. Nat. Cancer Inst., 1946-1947, 7: 189-197. 

14 refs. Squamous epithelial carcinoma 119 

in A mice, mammary adenocarcinoma in C3H mice, 

and sarcoma 37 in white mice of unknown 

genetic background were significantly retarded 

and spontaneous breast adenocarcinoma in C3H 

mice slightly retarded. Survival time was 

not increased. 

3543 

KlfÃ¹eva, N. G. PUTÃŒ BIOTERAPII RAKA. [PATHS 

OF CANCER BIOTHERAPY.] 

nauk, SSSR, 1946, No. 

Vest. Akad. med. 

2-3, 44-52. Translated 

in: Am. Rev. Soviet M., 1947, 4: 408-414 and 

in: MÃ©decin fr., 1947, 7: 8. The extract of 

Trypanosoma cruzi, designated as KR, was in 

jected into white mice with sarcoma 180. 

Subcutaneous, intramuscular and intratumoral 

KR injections in cases of various human can 

cers resulted in the lysis of tumor cells. 

Regression and absorption of the malignant 

tissue and regeneration shown by an increase 

of fibroblasts are some of the oncolytic re 

sults of KR, both experimentally and clini 

cally. 

3544 

Kliueva, N, G. and Bobritskaia. A. TS. DEISTVIE 

SCHIZOTRYPANUM CRUZI NA ZLOKACHESTVENNYE NOVO- 

OBRAZOVANlfA V EKSPERIMENTE. [THE EFFECT OF 

SCHIZOTRYPANUM CRUZI ON EXPERIMENTAL NEOPLASMS.] 

Bill. eksp. biol. med., 1946, 2j2: No. 2, 6-9. 

The findings of two series of experiments are 

reported. Mice (29 in the first, 49 in the 

second experiment) with Crocker sarcoma were 

given 0.05 cm3 blood of dogs infected with 

Schizotrypanum Cruzi. An average of 64-85% 

of the cases showed results, ranging from in 

hibition of tumor growth to complete tumor re 

gression. The serum was most effective when 

obtained from the blood of dogs with the in 

fection in its 10-14th day.



207 

TRYPANOSOMA CRUZI â€”¿ EFFECT 

(Continued) 


3545 KlfÃ¹eva, N. G. and Roskin, G. I. BIOTERAPIIA 

ZLOKACHESTVENNYKH OPUKHOLEI. [BIOTHERAPY 

OF MALIGNANT TUMORS.] Moskva, Akad. med. 

nauk SSSR, 1946. 224 p. 24 pi. Approx. 

90 reÃs. Armed Forces Medical Library has 

an English translation. 

voted to the description 

A monograÃ§h de 

of the KlfÃ¹eva- 

Roskin scram; its origin, mechanism of action, 

application and cancerolytic effects. The 

report includes both experimental and clini 

cal findings. 

3546 

Jedeloo, G. C., Lignac, G. 0. E., Ligtenberg, 

A. J. and Thiel, P. H. van. THE BIOTHERAPEUTIC 

ACTION OF TRYPANOSOMA CRUZI ON TAR CARCINOMA 

IN MICE. J. Nat. Cancer Inst., 1950, 10; 


med., Sect. 5, 1951, 4: No. 1029. 

3547 Jedeloo, G. C., Lignac, G. O. E., Ligtenberg, 

A. J. and Thiel, P. H. van. ONDERZOEK NAAR 

DE BIOTHERAPEUTISCHE WERKING VAN TRYPANOSOMA 

CRUZI OP MUIZENTEERKANKER. [BIOTHERAPEUTIC 

EFFECT OF TRYPANOSOMA CRUZI ON TAR PRODUCED 

CANCER IN MICE.] Ned. tschr. geneesk., 1949, 

93: 3147-3152. English summary. Endotoxin 

Ã’T trypanosoma cruzi applied against tar 

papilloma and tar carcinoma did not give en 

couraging results. 

3548 

Lob, M. L'ACTION DU SCHIZOTRYPANUM CRUZI SUR 

L'ADENOCARCINOME PROVOQUÃ‰ DE LA MAMELLE CHEZ 

LA SOURIS. [THE EFFECT OF SCHIZOTRYPANUM 

CRUZI ON INDUCED MAMMARY ADENOCARCINOMA IN 

MICE.] Schweiz. Zschr. allg. Path., 1950, 

13: 279-296. The experimental animals did 

nb"t show significant differences from the 

controls with respect to tumor changes and 

survival time. 

3549 

Lob, M. L'ACTION DE TRYPANOSOIIA CRUZI SUR LE 

CANCER EXPERIMENTAL DE LA SOURIS. [THE EFFECT 

OF TRYPANOSOMA CRUZI UPON EXPERIMENTAL CANCER 

554-556. IN MICE.] Abstracted Schweiz, med. in: Excerpta Wschr., 1949, med.,~S"ect. 79: 

5, 1950, 3: No. 51. No difference between 

treated and control animals was found. 

3550 

Malisoff, W. M. THE ACTION OF THE ENDOTOXIN OF 

TRYPANOSOMA CRUZI 

TUMORS. Science, 

(Kit)ON MALIGNANT MOUSE 

1947, 106: 591-594. 2 refs. 

"...the endotoxin of T. cruzi exerts a selec 

tive lytic effect on malignant tumors in mice, 

such as spontaneous mammary carcinoma and 

sarcoma 180." The endotoxin is not toxic to 

normal tissue under the conditions of therapy 

and in concentrations 4 times as great. 

3551 Roskin, G. I. TSITOLOGICHESKIE I GISTOLO- 

GICHESKIE IZMENENIIÃ„ ZLOKACHESTVENNYKH 

OPUKHOLEI POD VLIÃ•ANIEM SHIZOTRIPANNOGO 

ENDOTOKSINA. [CYTOLOGICAL AND HISTOLOGIC- 

AL CHANGES IN MALIGNANT NEOPLASMS AS EF 

FECTED BY THE ENDOTOXIN OF SCHIZOTRYPANUM 

CRUZI.] BfÃ¹l. eksp. biol. med., 1946, 22: 

No. 5, 18-20. Injections of Schizotrypa^ 

num Cruzi have tumortropic effects. The 

tumor tissue begins to turn blue, the cells 

of the center and the borders of the tumor 

change into a pale mass, and new connective 

tissue filaments intersperse the tumor. 

Schizotrypanum Cruzi acts cancerolytically 

on the tumor cells, but has no histological 

effects on other vital organs of the tumor 

host. It inhibits growth not only of adenocarcinoma 

but also of a variety of sarcomas. 

3552 

Spain, D. M Molomut, N. and Warshaw, L. J. 

PREPARATIONS OF LYSATES FROM CULTURES OF 

T. CRUZI AND 

TUMOR-BEARING 

THEIR EFFECTS 

MICE. Proc. 

ON NORMAL 

Soc. Exp. 

AND 

Biol., 

N. Y., 1948, 69: 134-136. 5 refs. 

3553 

Zubiri Vidal, A. EL TRATAMIENTO DEL CÃ•NCER 

(EL EXTRACTO K. R.). [TREATMENT OF CANCER 

(KR EXTRACT).! Farmacoter. 

1947, 4: 810-015. 15 refs. 

act., lladr., 

See 

150THERAPY3556 

3554 

Fraenkel, T. UNE ORIENTATION NOUVELLE DANS LE 

TRAITEMENT DU CANCER. [A NEW TREND IN THE 

TREATMENT OF CANCER.] Sem. h6p. Paris, 1947, 

M: 104-105. 

3555 

Galliard, H., Brumpt, L. C. and Martinez, R. 

INFECTIONS EXPÃ‰RIMENTALES A TRYPANOSOMA CRUZI 

CHAGAS CHEZ L'HOMME A PROPOS DE LA BIOTHÃ‰RA 

PIE DU CANCER. [EXPERIMENTAL TRYPANOSOMA 

CRUZI (CHAGAS' DISEASE) INFECTION IN MAN IN 

RELATION TO THE BIOTHERAPY OF CANCER.] Bull. 

Soc. path, exot., Par., 1950, 43: 204-216. 

Abstracted in: Biol. Abstr., BÃ¢Tt., 1951, 

25: No. 15392. "T. cruzi infections were 

pFoduced experimentally in 26 patients with 

advanced cancer. Although some transitory 

amelioration of their cancers was observed 

in some, no evidence was obtained that the 

infection prolonged the patients' lives..." 

- Biol. Abstr, 

3556 KlfÃ¹eva,JI. G. and Roskin, G. I. KANTSEROLITI- 

CHESKAIA SUBSTANTSlfÃ€ SCHIZOTRYPANUM CRUZI. 

[CANCEROLYTIC SUBSTANCE SCHIZOTRYPANUM CRUZI.] 

Vrach. dÃ©lo, 1946, 26: 105. Translation in: 

Am. Rev. Soviet M.,~T946, 4: 127-129. Essential 

ly the same as article in: Vrst. Akad. med. nauk, 

1946, No. 2-3, 44-52. 

3557 

THE K-R VACCINE. What's New, 1948, No. 121, 

12-13, 26. 8 refs. 

3558 

Talice, R, V., Pick, F. and PÃ©rez Moreira, L. 

.TENTATIVAS DE BIOTERAPIA POR T. CRUZI EN 

CASOS HUMANOS DE TUMORES MALIGNOS; INOCULA 

CIÃ“N DE TRYPANOSOMA CRUZI POR VÃ•A INTRAPERI- 

TONEAL EN UN CASO DE LINFOSARCOMA DE LOCALI- 

ZACIÃ“N PRIMARIA MESENTÃ‰RICA. [TESTS OF 

TRYPANOSOMA CRUZI BIOTHERAPY OF MALIGNANT 

TUMORS IN HUMANS; INTRAPERITONEAL INOCULA 

TION OF TRYPANOSOMA CRUZI IN A CASE OF 

LYMPHOSARCOMA OF PRIMARILY MESENTERIO LOCA 

LIZATION.] An. Fac. med. Montevideo, 1954, 

39: 207-224. 25 refs. English summary, 

rntraperitoneal Injections of Trypanosoma 

cruzi had only transitory effects on the 

overall condition of 4 patients with in 

operable tumors. 

See 

3543 

TRYPANOSOMA LEWIS! â€”¿ EFFECT 


3559 

Kajiwara, K. ON THE RECIPROCAL INTERFERENCE 

BETWEEN THE GROWTH OF YOSHIDA SARCOMA AND 

THAT OF TRYPANOSOMA LEWISI. Gann, Tokyo, 

1950, 41: 123-125. In English.



208 

TRYPTOPHAN, D- 

3560 Gessler, A. E., McCarty, K. S. and Parkinson, 

II. C. RETARDATIONOF THE GROWTHOF MOUSE 

TUMORSBY D-AMINO ACID THERAPY. Exp. M 

& S., 1950, 8: 168-186. 13 reÃs. Abstracted 

in: Chem. Abstr., 1950, 44: 1092oe. 

TYPHUS VACCINE 

see VACCINES â€”¿ THERAPY 

See 

2746 

URACIL, 

Sec 

234 2941 

URACIL, 

TYROSTNE, O-METHYL-L- 

4-AMINO- 

4-METHYL-5-DI(2-CHLOROETEYL)AMINOsee 

NITROGEN MUSTARDS - URACIL, 4-METHYL-5- 

DI(2-CHLOROETHYL)AMINO- 

URACIL, 

3560a 

Brugsch, J. ZELLGIFTE ALS KLINISCHES PROBLEM. 

[CELL POISONS AS CLINICAL PROBLEMS.] Zschr. 

ges. uni. Ned., 1950, 5: 528-530. Among the 

substances discussed are colchicine, urethane, 

raethylthiouracil and trypaflavine. 

See 

1776 3562 

URACIL, 

METHYL THIC- 

PROPYLTHIO- 

3561 

Â»Picha, E. THYREOSTATIKA BEI KARZINOM. [THYRO- 

STATICS IN CARCINOMA.] Wien, med. Wschr., 

1953, 103: 154-155. 

URACIL, THIO -, â€”¿ EFFECT 


3562 

Â«Gordina, S. N. VLIIANIE ANTITIREOIDNYKH VESHCHESTV 

NA ROST PEREVIVAEMYKH OPUKHOLEI. [EFFECT OF 

ANTITHYROID SUBSTANCES ON THE GROWTH OF TRANS 

PLANTED TUMORS.] Nauch. izv. kazakh. med. inst., 

1953, No. 11, 133-138. Sulfathiazol and sulfidin 

promoted, thiouracil had no effect and sulfonamides 

occasionally inhibited tumor growth in mice 

with Ehrlich ascite carcinoma. Thiouracil and 

methylthiouracil inhibited considerably the 

Crocker sarcoma in rats. Excision of the thyroid 

inhibited tumor growth in both rats and mice. 

3563 

Gordina, S. N. VLIÃ•ANIE GORMONA SHCHITOVIDNOI 

ZHELEZY NA RAZVITIE PEREVIVAEMYKH I INDUTSI- 

ROVANNYKH OPUKHOLEI. [EFFECT OF THYROID HOR 

MONE ON THE DEVELOPMENT OF IMPLANTED AND IN 

DUCED NEOPLASMS.] Doklady Akad. nauk SSSR, 

1952, 84: 1269-1272. 6 refs. Following 

thyroid"e~ctomyor application of thiouracil, 

transplanted Ehrlich carcinoma, Crocker 

Sarcoma and Sarcoma M-l in white mice showed 

tumor regression. 

3564 

Rulla, L. TIURACILE E TUMORI. [THIOURACIL 

AND TUMORS.] Neoplasie, Tor., 1947, 2: 

191-204. 37 refs. Thiouracil in doses of 

50 g was injected subcutaneously into albino 

rats. Both the growth of Ehrlich adenocarcinoma 

and the survival time were increased. 

The tumors had a tendency to necrose and 

ulcerate, which was attributed to the de 

creased function of thyroid produced by the 

thiouracil. 


3565 

Vogel, M. and McGavack, T. H. EFFECTS OF THIO 

URACIL ON HEMOPOIETIC SYSTEM OF ALBINO RAT. 


â€¢¿tab. 25 refs. 

EFFECT 


3566 Nichols, C. W., Jr. THIOURACIL INHIBITION OF 

TOBACCO-MOSAIC VIRUS MULTIPLICATION. Phyto 

pathology, 1953, 43J 555-557. 


3567 

Bernard, J., Deltour, G., Christol, D., Velez, 

E. and Colvez, P. ESSAI DE TRAITEMENT DE 

LA LEUCÃ‰MIE MYÃ‰LOIDE CHRONIQUE PAR LE THIO- 

URACILE; REMARQUABLE RÃ‰MISSION DES DÃ‰SORDRES 

SANGUINS. [ATTEMPTED TREATMENT OF CHRONIC 

MYELOID LEUKEMIA BY THIOURACIL; REMARKABLE 

REMISSION OF BLOOD DISORDERS.] Bull. Soc. 

mÃ©d. hop. Paris, 1951, 67: 1024-1029. 

14 refs. 

3568 

ESSAI DE TRAITEMENT DE LA LEUCÃ‰MIE MYÃ‰LOIDE 

CHRONIQUE PAR LE THIOURACILE. [THIOURACIL 

THERAPY OF CHRONIC MYELOID LEUKEMIA.] Med. 

& hyg., GenÃ¨ve, 1951, 9: 477. 

3569 

Hansen-Pruss, O. C. THIOURACIL IN THE TREAT 

MENTOF LEUKEMIA. Proc. 

N. Y., 1947, 64: 496-500. 

Soc. Exp. 

4 refs. 

Biol., 

Abstract 

ed in: Biol. Abstr., Bait., 1947, 21; No. 24912 

3570 Landau, A. O STOSOWANIU METYLOTIOURACYLU W 

BIAtACZCE SZPIKOWEJ. [METHYLTHIOURACIL IN 

THERAPY OF LEUKEMIA.] Polski tygod. lek., 

1952, 7: 701-704. 

3571 

Valdes Ruiz, M. and Juanes Gonzalez, A. LEU 

CEMIAS, METABOLISMO BASAL Y TIOURACILO. 

[LEUKEMIAS, BASAL METABOLISM AND THIOURACIL.] 

Arch. med. exp., Madr., 1952, 1Â£: 21-24. 

3 refs. English summary. Thiouracil was 

of no use in the treatment of leukemias. 

See 

598 

UREA, HEXAMETHYLENEDIETHYLENE- 

See 

3358 3364 

UREA, THIO 

See 

2974 

URETHAN 

see CARBAMATE, ETHYL 

URINE EXTRACT â€”¿EFFECT ON TUMOR GROWTH 

3572 

Fleming, R., Walters, C. L. and Williams, J. L. 

THE EFFECT OF ADRENAL 

ON MALIGNANT TISSUE. 

AND URINARY EXTRACTS 



3573 

Wollheim, E. HEMMUNGSWIRKUNG AN EXPERIMENTELLEN 

MXUSEKARZINOMEN. EIN HEMMUNGSSTOFF AUS NORMALEM 

URIN. [INHIBITORY ACTION ON EXPERIMENTAL CAR 

CINOMA IN MICE. AN INHIBITOR FROM NORMAL URINE.] 

Schweiz, med. Wschr., 1948, 78: 428-431. 21 refs. 

A substance present in the urTne of healthy 

human subjects but not in the urine of carcinoma 

patients inhibits experimental carcinoma. The 

extracts from normal men showed a stronger ef 

fect on carcinoma in female mice while extracts 

from normal women had a more marked effect when 

used in male mice. The active factor probably 

belongs to the steroid group.



209 

URINE EXTRACT â€”¿ METABOLISM (INCLUDING EFFECTS 


see also VITAMINS. 

Bl4 

3574 Fleming, R. F. and Peczenik, O. ALKALINE PHOS- 

PHATASE AND TUMOUR INHIBITION. Nature, Lond., 

1948,. 162: 338-339. 5 refs. Extracts of 

arine aÃ±a"colchicine caused a diminution of 

alkaline phosphatase in tumors, while stilbestrol 

caused an increase. 

THERAPY 

3575 

JimÃ©nez de Asua, F. and Villar, I. del. EL 

TRATAMIENTO DE LAS LEUCEMIAS POR EL METODO 

DE MILLER. [THE TREATMENT OF LEUKEMIAS WITH 

THE MILLER METHOD.] 

1948, 55: 1191-1195. 

Sem. med., 

4 refs. 

B. Air., 

See 

232 3605 

URINE EXTRACT. 

(H-ll) 

3576 AlemÃ¡n Caballero, J. SOBRE EL EMPLEO DEL EX 

TRACTO H. 11, COMO INHIBIDOR EN LA CANCERO 

LOGIA. [ON THE USE 0F H. 11 AS A CANCER 

INHIBITOR.] Gac. mÃ©d. espaft., 1946, 20: 

215-217. 13 refs. 

3577 

H 11 IN MALIGNANT DISEASE. 

M. J., 1948, Â£: 716. 


An editorial. 

Brit. 

3578 

Fleming, R. F., Jury, L. R. and Thompson, J. H. 

ORAL ADMINISTRATION 

World, Lond., 1951, 

OF H 11 EXTRACT. Med. 

74: 629-631. 5 refs. 

3579 

AN INQUIRY INTO THE EFFECT OF H 11 IN THE TREAT 

MENT OF MALIGNANT DISEASE. REPORT OF A COM 

MITTEE APPOINTED BY THE MEDICAL 

COUNCIL. Brit. M. J., 1948, 2: 

RESEARCH 

701-708. 

3 refs. "No growth-inhibiting effect of H 11 

could be demonstrated in experiments in which 

grafted Twort carcinoma was 

nor in experiments in which 

the test tumour... 

a grafted spindlecell 

sarcoma in homologous mice was tested... 

H 11 had no effect on the growth rate of 

spontaneous mammary cancer in inbred mice as 

compared with that of similar untreated tu 

mours...New tumours were not prevented from 

arising, and metastasis 

of the treatment." 

took place in spite 

3580 

Williams, J. L. and Walters, C. L. TUMOURIN 

HIBITION WITH EXTRACTSOF URINE. Nature, 

Lond., 1947, 159: 503-504. 5 refs. Ab 


1: No. 2102. 

See 

3593 

THERAPY 

3581 

BaBuelos GarcÃa, M. SOBRE EL TRATAMIENTO 

MEDICO DE LOS TUMORES MALIGNOS. [MEDICAL 

THERAPY OF MALIGNANT TUMORS.] Gac. mÃ©d. 

espaÃ±., 1946, 20: 273-275. 

3582 

H 11 NEI TUMORI MALIGNI. [H 

TUMORS]. Medico condotto, 

11 IN MALIGNANT 

1948-49, 46: 57- 

59. 3 refs. The substance is considered 

to have anti-cancer properties. 

not 

3583 

Â»Halberstaedten, L. A SURVEY OF EXPERIMENTS ON 

THE TREATMENT OF CANCER. 

1947, 33: 84-86. 

Harefuah. Tel Aviv, 

3584 

Josephs, H. and Curtis, F. H 11 IN MALIGNANT 

DISEASE. Brit. M. J., 1948, 2: 876-877. 

Report of 3 cases, in 2 of which favorable 

results were obtained. 

3585 

King, T. S. and Lees, B. H 11 IN MALIGNANT 

DISEASE. Brit. M. J., 1948, 2: 957. A 

discussion. 

3586 

Ollerenshaw, G. J. W. DIE BEHAJCDLUNG MALIGNER 

TUMOREN MIT H-11-EXTRAKT. [THE TREATMENT 

OF MALIGNANT TUMORS WITH H-ll EXTRACT.] Klin. 

Med., Wien, 1947, 2: 890-898. 15 refs. 

3587 

Ollerenshaw, G. J. W. H 11 EXTRACT. North Wing, 

Sheffield, 1948, Spring, 8-13. 25 refs. 

3588 

Ollerenshaw, G. J. W. H 11 EXTRACT; A BRIEF 

ACCOUNT OF ITS PREPARATION, STANDARDIZATION, 

EXPERIMENTAL 

Med., 1948, 

AND CLINICAL 

55: 149-155. 

RESULTS. 

24 refs. 

Clin. 

3589 

Ollerenshaw, G. J. W. OBSERVATIONS ON DOSAGE 

OF H 11 EXTRACT. Med. 

6_4: 72-76. 3 refs. 


3590 

Ollerenshaw, G. J. W. SOME FAVOURABLE RESULTS 

OF H 11 THERAPY IN CANCER. 

1947, 67: 43-50. 8 refs. 

Med. World, Lond., 

3591 

Ollerenshaw, G. J. W. and Lowe, E. C. 1948 

REPORT ON THE CLINICAL RESULTS OF H 11 

THERAPY IN CANCER. Med. 

68: 552-559. 24 refs. 


3592 

Ollerenshaw, G. J. V. and Lowe, E. C. 1949 

REPORT 

Lond., 

ON H 11 THERAPY IN CANCER. 

1949, 71: 79-85. 8 refs. 

Med. World, 

3593 

Paya Diaz, F. and Valencia Cellier, E. CANCER 

Y EXTRACTO H. II. [CANCER 

Farmacoter, actual, Madr., 

AND EXTRACT H. II.] 

1948, 5: 626-630. 

3594 

Penistan, A. H. H 11 IN MALIGNANT DISEASE. 

Brit. M. J., 1948, 2: 917. Favorable results 

in 7 cases. 

3595 

Rosenfeld, G. and Mondes, F. T. TENTATIVA DE 

TRATAMENTO DA 

PELO "H 11." 

MIELOSE LEUCEMICA CRONICA 

[ATTEMPTED THERAPY OF CHRONIC 

MYELOID LEUKEMIA WITH H 11.] Rev. paÃºl, med., 


3596 

Thompson, J. H. and Lowe, E. C. PROGRESS IN 

H 11 THERAPY FOR CANCER. Med. World, Lond., 

1950, 73: 283-287. Analysis of 2,277 cases 

of inoperable cancer shows that H 11 therapy 

was beneficial in 70.1 per cent of them. 

3597 

Thompson, J. H. and Ollerenshaw, G. J. #â€¢H 11 

IN MALIGNANT DISEASE. 

835-837. Discussion: 

Brit. M. J., 

p. 836-837. 

1948, 2: 

3598 

Ward, G. A GREAT ADVANCE IN H 11 TREATMENT. 

Med. World, Lond., 1951, 75: 460-461. 

3599 Â«ard, G. THE TRUTH ABOUT H 11. Med. World, 

Lond., 1948, 69: 331-333. Results obtained 

with H 11 in TZ inoperable cases of cancer 

are described.



aio 

VACCINE, 

KR 

see TRYPANOSOMA CRU ZI 

3600 Penha, G. H. ÃœBERZWEI FALLE VON TUMOREN AUS 

DEM OTO-RHINO-LARYNGOLOGISCHEN GEBIET, DIE 

AUF EINE 

WURDEN. 

AUSSERGEWOHNLICHE WEISE BEHANDEIT 

[TWO CASES OF CTO-RHINO-LARYNGOLO- 

GICAL TUMORS TREATED BY AN UNUSUAL METHOD.] 

Pract. otorhinolar., Basel. 1951, 13: 167- 

176. 

VACCINES â€”¿ EFFECT 

see also 

PYRIFER 


3S01 

Audier. A. G. CHEMOTHERAPY OF CARCINOMA IMPROV 

ED BY HOST CONDITIONING. I. BACTERIAL ME 

TABOLITES AND FROZEN TUMOR MATERIAL COMBINED 

WITH HORMONALLY ACTIVE DRUGS. Antonie van 

Leeuwenhoek, Amst., 1953, 19: 83-92. 10 refs. 

"Mammary adenocarcinomas in mice necrotized 

and were shed in 4 of 9 animals when a vac 

cine of bacteria isolated from an ulcerative 

tumour was injected simultaneously with an 

extract of Glycyrrhiza glabra. Adrenocorticotropin 

did not have a similar effect in 4 

mice. A stronger necrotizing effect was ob 

tained 

tumour 

when the vaccine 

material." 

was replaced by frozen 

3602 

Higgins, G. K. and Pack, G. T. THE EFFECTS OF 

VIRUS THERAPY ON THE MICROSCOPIC STRUCTURE OF 

HUMAN MELANOMAS. Am. J. Path., 1951, 27: 

728-729. Discussion: p. 729. 

See 

1926THERAPY 

3603 

Campos, S. da S. A POL IVAC INACÃ„O NO THATAMENTO 

DO CANCER. RESULTADOS OBTIDOS. [POLYVACCINA- 

TION IN THE TREATMENT OF CANCER; RESULTS.] 

Rev. brasil, cancerol., 1950, 3J 17-26. 

English summary, pi. tab. "...of 512 

patients having far advanced cancer...in 7 

patients a total regression of the turner 

took place...The A. did not use Coley toxin 

nor injection of Schizotripanum cruzi..." 

3604 

Higgins, G. K. and Pack, G. T. VIRUS THERAPY 

IN THE TREATMENT OF TUIIORS. Bull. Hosp. 

Joint Dis., N. Y., 1951, 12: 379-382. 6 refs. 

3605 

Odio de Granda, G. and Zequeira Rivera, G. 

VACUNA CONTRA EL CANCER; NOTA PREVIA. 

[VAGINE THERAPY AGAINST CANCER; PRELIMINARY 

REPORT.] Rev. Kuba med. trop., 1948, 4: 

113-114. English summary. Vaccine, pre 

pared from the urine of cancerous patients 

with the addition of pulp from spleen, has 

been injected into a small number of patients 

with advanced cancer. There was great im 

provement in all of them. 

36pack, G. T. NOTE ON THE EXPERIMENTAL USE OF 

RABIES VACCINE FOR MELANOMATOSIS. A.M.A. 

Arch. Derm., 1950, 62: 694-695. 

3607 

Szreder, W. and Migdalska, Z. TYMCZASOWEWYNIKI 

LECZENIA PRZEWLEKtYCH BIAtACZEK SZPIKOWYCH 

ROWNOCZEÃ¡NIE URETANEM, IPERYTEM AZOTOWYMI 

SZCZEPIONKA DELBETA. [PRELIMINARY RESULTS OF 

COMBINED URETHANE, NITROGEN MUSTARD AND DELBET'S 

VACCINE THERAPY OF CHRONIC MYELOCYTIC LEU- 

KEMIAS.] Polski tygod. lek., 1951, tÃ: 620-624. 

16 pefs. English summary. [addendum] p. 99. 

3608 Weiss, E. TREATMENT OF MALIGNANCY WITH 'TUMOR 

VACCINE." Urol. Cut. Rev., 1952, 56: 36-39. 

3 refs. "Vaccine reduces size of Ã¯Umor." 

3609 

Zil'ber, L. A. and RadzikhovskafÃ , R. M. EÃ‡SPERI- 

MENTAL'NOE IZUCHEJIIE IMMUNITETA K OPUKHOLIAM. 

I. ISKUSSTVENNAIA IMMUNIZATSIÃ•A PROTIV KARTSI- 

NOMY BROUN-PIRS. [EXPERIMENTAL STUDIES ON 

IMMUNITY TO NEOPLASMS. I. ARTIFICIAL IMMUNI 

ZATION AGAINST BROWN-PEARCE CARCINOMA.] Zh. 

mikrob., Moskva, 1954, No. 9, 64-70. Vaccines 

consisting of tumor cells in combination with 

an anti-tumor drug(urethane, arsenic, acetate, 

etc.) when administered to mice render the 

animals immune to subsequent Brown-Pearce tumor 

implants. Ether, chloroform and iodine in com 

bination with cancer cells did not result in 

a successful immunizing vaccine. The vaccine 

administered following tumor implantation did 

not prevent tumor growth. 

See 

2960 

VASODILATORS 

See 

3266 

VENOMS 

3610 

Bobeau, G. RÃ‰SULTATSACTUELS DU TRAITEMENT 

ANTICANCÃ‰REUXPAR EXTRAITS DEVENJMÃ‰SD'OR 

GANISMES OPHIDIENS (E.D.O.O.) SPECIALEMENT EN 

MATIÃˆRE DE CANCER DU SEIN. [PRESENT STATUS 

OF THERAPY OF CANCER WITH DEVENOMIZED SNAKE 

EXTRACTS, ESPECIALLY BREAST CANCER.] 

path, comp., Par., 1946, 46: 619-627. 

Rev. 

3611 

Grundmann, I. DIE SCHLANGENGIFTE, IHRE PHARMA 

KOLOGIE, TOXIKOLOGIE UND IHRE THERAPEUTISCHE 

VERWENDUNG. [SNAKE VENOMS; PHARMACOLOGY, 

TOXICOLOGY AND THERAPEUTIC USE]. Med. Mschr., 

1950, 4: 570-575. For clinical and experi 

mental use of snake venom in tumors, see 

especially, p. 571. 

3612 

Â»Melik-Karamian, A. S. VLIIANIE IADOV SREDNE- 

AZIATSKIKH ZMEÃ• NA NEKOTORYE Ã•Ã•ZIOLOGICHESKIE 

I PATOLOGICHESKIE PROTSESSY V ORGAN!ZME. 

(PREIMUSHCHESTVEMO V ONKOLOGII). [THE EFFECT 

OF VENOM OF CENTRAL-ASIATIC SNAKES ON PHYSIO 

LOGICAL AND PATHOLOGICAL PROCESSES IN THE 

ORGNISM (PREDOMINANTLY IN ONCOLOGY). 165 p. 

Tashkent, 1947. Venoms of cobra and viper 

were experimentally used in treating Jensen 

and KrichevskiÃ¯-Sinel'nikov rat sarcomas. 

Clinically the venoms were used on cancers 

of the esophagus resulting in a decrease of 

the size of the tumor and general improve 

ment of the patients' condition. 

3613 

Schmitz, H. DIE WIRKUNG DES BIENENGIFTES AUF 

DEN ZELLSTOFFWECHSEL VON TUMORZELLEN. [EF 

FECT OF 

LISM.] 

BEE VENOM ON TUMOR CELLULAR METABO 

Arzneimitt. Forsch., 1951, 1: 360- 

362. 24 refs. 

3614 Seliger, H. NEUERE ERKENNTNISSE ÃœBERDIE 

KLINISCHE EINWIRKUNG VON COBRATOXIN AUF 

MALIGNE TUMOREN. [NEW RESULTS KITH COBRA 

TOXIN IN CANCER THERAPY.] Med. iÂ»elt., 

1951, 20: 638. 

VENOMS, BEE 

3615 

Albert, Z. JAD PSZCZELNY W PRACACH 

DOSWIADSZALNYCH NAD NOWOTWORAMI. [BEE'S 

VENOM IN EXPERIMENTAL STUDIES OF NEO 

PLASMS] . Pat. polska, 1952, 3: 108-111. 

3 refs. English summary. "No inhibitory 

effect of bee is venom on the growth of neo 

plasms could be ascertained."



â€¢¿ *Â»â€¢â€¢.- 

211 

VENOMS, 

BEE (Continued) 

3616 Havas, L. J. TRAVAUX D'APPROCHE DU PROBLEME 

DU CANCER PAR LE VENIN D'ABEILLES. III. 

SUR QUELQUES INVESTIGATIONS CONVERGENTES. 

[THE APPROACH TO THE PROBLEM OF CANCER 

THROUGH BEE VENOM. III. SOME CONVERGING 

INVESTIGATIONS.] Apic. haut-rhinois., 

1951, No. 6, 89-90. 9 reÃs. Abstracted 

in: Bee World, 1953, 34: No. 4, 83. Bee 

venom has both tumor-Inducing and tumor 

inhibiting effects. Honey and Vitamin K 

have analogous anti-haemorrhagic and 

tumor-inhibiting effects. 

3617 Havas. L. J. and Rebert, F. TRAVAUX D'APPROCHE 

DU PROBLEME DU CANCER PAR LE VENIN D'ABEILLES. 

II. LE CANCER VEGETAL ET LE VENIN D'ABEILLES. 

[APPROACH TO THE PROBLEM OF CANCER THROUGH 

BEE VENOM. 

Apic. als. 

II. PLANT CANCER AND BEE VENOM.] 

lorr., 1951, 1: 9-13. Abstracted 

in: Bee World, 1953, 34: No. 4, 84. Plants 

treated with Apirene(Fee-venom preparation) 

had fewer tumors than 

Apicine or D3(another 

untreated 

bee-venom 

plants. 

substance) 

destroyed large plant tumors which were in 

duced by colchicine. 

3618 

Havas, L. J., HÃ©bert, F. and Baldensperger, A. 

Ã€ LA RECHERCHE DE PRINCIPE ANTITUMORAL DANS 

L'AGENT STERILISATEUR DU POLLEN SECRETE PAR 

LES ABEILLES. I. EFFETS D'EXTRAITS DE 

POLLEN STERILISE 

TUMOR-INHIBITING 

ET DE LA VITAMIN 

PRINCIPLE IN THE 

E. [THE 

POLLEN- 

STERILIZING SUBSTANCE SECRETED BY BEES. I. 

EFFECT OF EXTRACTS OF 

OF VITAMIN E.] Apic. 

STERILIZED POLLEN AND 

haut-rhinois, 1951, 

8: 111-115. 12 refs. 

Abstr., 1955, 49: No. 


1888g. "Various 

extracts of inactivated pollen and of 

crushed bees inhibited tumor growth in 

wheat;...The bee extract inhibited the 

growth of stem but not of root tumors; it 

did not inhibit somatic growth." -Chem. 

Abstr. 

VERATRINE â€”¿ EFFECT 

See 

15 

VICTORIA BLUE 

See 

2950 

VIRAL COMPOUNDS, ANTI â€”¿ EFFECT 

3619 

Gottschalk, R. G. THE DETECTION OF VIRUSES 

IN TUMORS AND ATTEMPTS AT ANTIVIRAL THERAPY. 


7: 250-255. 20 refs. "Antivirus therapy 

Ts at present very inadequate. Previous 

attempts of treatment of Rouss [sic] sarcoma 

are reviewed. Aureomycin, terramycin, malononitrile, 

acriflavine, ACTH and cortisone 

failed in our hands to influence the produc 

tion of tumors by the Rouss [sic] virus. 

9-aminoacridine interfered with the develop 

ment of tumors only 

methionlne possibly 

by its toxicity. Dl- 

promoted tumor formation." 

See 

1014 

VIRUSES 

3620 

Siegert, H. DIE ONKOLYTISCHEN EIGENSCHAFTEN 

VON VIREN. [ONCOLYTIC 

Arch ges. Virusforsch. 

PROPERTIES OF VIRUSES.] 

Wien, 1955, 6: 93-117. 

Bibliography: p. 116-117. A reviewT 


3621 

Ginder, D. R. TUMOR-DESTROYING EFFECTS OF 

VIRUSES. In: Antimetabolites and cancer. 


Advanc. Sc., 1955, 243-251. 20 refs. 

3622 

Ginder, D. R. and Friedewald, W. F. EFFECT OF 

SEMLIKI FOREST VIRUS ON 

Soc. Exp. Biol., N. Y,, 

RABBIT FIBROMA. Proc. 

1951, 77: 272-276. 

7 refs. 

3623 

Ginder, D. R. and Friedewald, W. F. EFFECT 

OF SEMLIKI FOREST VIRUS ON RABBIT MYXOMA. 

Proc. Soc. Exo. Biol., N. Y., 1952, 79: 

615-618. 4 refs. Fatality rate was re 

duced to 62%. 

3624 

Hamazaki, Y., Omori, T., Sato, H. and MiyakÃ©, K. 

ON THE IMMUNO-SEROLOGICAL STUDIES ON THE HST 

(HAMAZAKI) VIRUS. Gann, Tokyo, 1954, 45: 344- 

346. In English. Seventeen of 41 WisTfar 

strain rats (41.5%) were completely immunized 

against Yoshida sarcoma by intramuscular in 

jections of HST virus emulsion. The serum of 

rabbits strongly immunized with the virus also 

acted on Yoshida tumor transplants in hybrid 

rats. 

3625 

Koprowska, I. and Koprowski, H. MORPHOLOGIC AND 

BIOLOGIC CHANGES IN A MOUSE ASCITES TUMOR FOL 

LOWING 


INDUCED INFECTION WITH CERTAIN 

Res., 1953, 13: 651-660. pi. 

VIRUSES. 

18 refs. 

3626 Love, R., Koprowski, H. and Cox, H. R. CYTO- 

LOGICAL STUDIES ON THE EHRLICH ASCITES TUMOR 

BEFORE AND AFTER INFECTION WITH BUNYAMWERA 

VIRUS. 

1 pi. 


30 refs. "Bunyamwera~~virus infection 

of the Ehrlich ascites tumour results in a 

selective destruction of the tumour cells. 

The destructive process involves the intermitotic 

phase of the cell; it is characterized 

by the development of prominent pseudonucleoli 

in a large proportion of infected cells and by 

the occurrence of multiple nuclear budding si 

milar to, but more pronounced than, that which 

is occasionally 

tumour cell." 

observed in the uninfected 

3627 

Lynn, J. W., Jr. and Morgan, H. R. CYTOPATHO- 

GENICITY OF ANIMAL VIRUSES IN VITRO. A. M. A 

Arch. Path., 1954, 57: 301-316. 42 refs. 

A review. See particularly, viruses with 

cytopathogenic effects on malignant tissue: 

p. 310-314. 

3628 

Moore, A. E. THE DESTRUCTIVE EFFECTS OF VIRUSES 

PN TRANSPLANTABLE MOUSE TUMORS. Acta Unio 


"Of the neurotropic viruses studied, the 

following were effective against some transplantable 

mouse tumors: West Nile, Venezuelan, 

Ilheus, Bunyavera, and St. Louis encephalitades. 

Other encephalitis viruses studied, Semiliki 

Forest. 

and 17D 

Jap B, Eastern Equine, Columbia SK 

Yellow Fever were without effect. 

Each of the effective viruses was found to 

cause necrosis of some tumors and not others, 

so that each virus appeared to have its own 

spectrum of susceptible and non-susceptible 

tumors. The reason for this striking tumor 

specificity is unknown. Certainly, it does 

not appear to be due to hlstological structure 

since sarcomas, carcinomas and osteogenic 

sarcomas have been shown to be in both groups." 

3629 

Moore, A. E. EFFECTS OF VIRUSES ON TUMORS. 

Ann. Rev. Microbiology, 1954, 8: 393-410. 

98 refs.



212 

VIRUSES â€”¿ EFFECT 

ON TUMOR GROWTH (Continued) 

3630 

Moore, A. E. VIRUSES WITH ONCOLYTIC PROPERTIES 

AND THEIR ADAPTATION 

Acad. Sc., 1952, 54: 

TO TUMORS. Ann. N. York 

945-952. 7 refs. 

3631 

Moore, A. E. and Diamond, L. C. INFLUENCE OF 

HEMAGGLUTINATING VIRUSES ON TUMOR CELL SUS 

PENSIONS. I. GROWTH INHIBITION AND RE 

VERSAL 

N. Y., 

OF THE EFFECT. Proc. Soc. Exp. 

1952, 79: 663-669. 2 refs. 

Biol., 

3632 

Pollard, M., Bussell, R. and Snyder, C. C. 

THE EFFECT OF VIRUSES ON HUMAN NEOPLASMS IN 

TISSUE CULTURES. Tex. 

12: 336-340. 13 refs. 

Rep. Biol. M., 1954, 



3633 Southam, C. M. and Epstein, J. D. THE EFFECT 

OF RUSSIAN ENCEPHALITIS AND OTHER VIRUSES 

ON MOUSE 

581-586. 

LEUKEMIA. 

11 refs. 



med., Sect. 16, 1954, 2: No. 1184. R.S.S.E. 

virus inhibited leukocytosis and organ in 

filtration in Ak4 mouse leukemia. Survival 

time was not affected. Slight antileukemic 

effect was produced by the Massachusetts 

strain of N.D.V., Uganda S virus, Anopheles 

B virus, Bunyamawera virus and Theileris 

G. D. VII virus. Nine other strains of 

viruses had no effect. 

3634 Stoler, M. and Gey, M. K. DESTRUCTION OF A 

HUMAN FIBROSARCOMA STRAIN (A.Fi.) IN TISSUE 

CULTURES FOLLOWING THE GROWTH OF POLIOMYE 

LITIS VIRUSES. A PRELIMINARY REPORT. Bull. 

Johns Hopkins Hosp., 1953, 92: 3S5-393. 

5 refs. 

3635 Takemori, N., Nakano, M., Hemmi, M., Ikeda, H., 

Yanagida, S. and Kitaoka, M. DESTRUCTION OF 

TUMOUR CELLS BY RIFT VALLEY FEVER VIRUS. 

Nature, Lond., 1954, 174: 698-700. M refs. 

Abstracted in: Excerpta med., S^ct. 16, 1955, 

3: No. 3105. 

3636 

Takemori, N., Nakano, M., Hemmi, M., Ikeda, H., 

Yanagida, S. and Kitaoka, M. EFFECT ON IN 

FECTION WITH SEVERAL VIRUSES UPON TUMOR CELLS 

GROWN IN VITRO. Gann, Tokyo, 1954, 45: 381- 

383. In English. Among the virusesTested 

the Rift Valley fever virus (pantropic and 

neurotropic strains) was found to have the 

most pronounced inhibiting effect both in 

vivo and in vitro. 

3637 

Toolan, H. W. and Moore, A. E. ONCOLYTIC EFFECT 

OF EGYPT VIRUS ON A HUMAN EPIDERMOID CARCINOMA 

GROWN IN X-IRRADIATED RATS. Proc. Soc. Exp. 

Biol., N. Y., 1952, 79: 697-702. 2 pi. 4 refs. 

See 

3656 

â€”¿MODE OF ACTION 

See 

1635 THERAPY 

3638 

Higgins, G. K. and Pack, G. T. VIRUS THERAPY 

IN THE TREATMENT OF TUMORS. Bull. Hosp. 

Joint Dis. N. Y., 1951, 12: 379-382. 6 refs. 

"...over 30 patients with~~multiple mÃ©tastases 

of melanoma have been treated by virus therapy. 

Of this number 8 have shown definite regression 

of their mÃ©tastases. These have decreased in 

size, become flattened,but have remained pigmented." 

3639 Newman, W. and Southam, C. M. VIRUS TREATMENT 

IN ADVANCED CANCER. A PATHOLOGICAL STUDY OF 

FIFTY-SEVEN CASES. Cancer, Phila., 1954, 7: 

106-118. 27 refs. 

3640 

Pollard, M. and Snyder, C. C. TREATMENT OF A 

HUMAN 

Biol. 

CANCER CASE WITH VIRUSES. Tex. 

M., 1954, 12: 341-344. 5 refs. 

Rep. 


3: No. 1776. 

3641 Southam, C. M. and Moore, A. E. CLINICAL 

STUDIES OF VIRUSES AS ANTINEOPLASTIC AGENTS, 

WITH PARTICULAR 

Cancer, Phila., 

REFERENCE TO EGYPT 101 VIRUS. 

1952, 5: 1025-1034. 18 refs. 

3642 

Southam, C. M. and Moore, A. E. WEST NILE, 

ILHEUS, AND BUNYAMWERA VIRUS INFECTIONS IN 

MAN. Amer. J. trop. Med., 1951, 31: 724- 

741. 23 refs. No significant effect on 

growth of the neoplasms was observed but 

localization of the virus in tumors was 

shown in some of the patients with each 

of the three viruses. 

VIRUSES. ENCEPHALITIS AND ENCEPHALOMYELITIS 

3643 

Bang, F. B. and Gey, G. O. COMPARATIVE SUSCEP 

TIBILITY OF CULTURED CELL STRAINS TO THE 

VIRUS 

Bull. 

OF EASTERN EQUINE ENCEPHALOMYELITIS. 



3644 

Buckley, S. M., Buckley, J. J. and Snipes, A. E. 

THE EFFECT OF ST. LQUIS ENCEPHALITIS VIRUS ON 

TRANSPLANTABLE 

Cancer, N. Y., 

CROCKER MOUSE SARCOMA 180. 

1951, 4: 367-374. 12 refs. 

3645 

Koprowska, I. MORPHOLOGIC CHANGES OF EXFOLIATED 

CELLS IN EFFUSIONS OF CANCER PATIENTS FOLLOW 

ING INDUCED 

SERVATIONS. 

VIRAL INFECTIONS. PRELIMINARY OB 

Am. J. Path., 1953, 29: 1105-1121. 

4 tab. 12 refs. Abstracted in: Excerpta med., 

Sect. 16, 1954, 2: No. 2159. 

3646 

Koprowska, I. and Koprowski, H. EFFECT OF 

MENGO ENCEPHALITIS VIRUS ON THE EHRLICH 

ASCITES TUMOR OF THE MOUSE. J. Nat. Cancer 

Inst., 1953, 14: 627-643. pi. 4 refs. 

3647 Love, R. and Sharpless, G. R. STUDIES ON A 

TRANSPLANTED CHICKEN TUMOR(RPL-12 LYMPHOMA). 

II. MECHANISM OF REGRESSION FOLLOWING IN 

FECTION WITH AN ONCOLYTie VIRUS. Cancer 

Res., 1954, ÃŒA: 640-647. 2 pi. 20 refs. 

3648 

Love, R. and Sharpless, G. R. STUDIES ON A 

TRANSPLANTED CHICKEN TUMOR (RPL-12 LYMPHOMA). 

III. CYTOLOGICAL CHANGES DURING VIRUS-IN 

DUCED ONCOLYSIS. Cancer Res., 1954, 14: 758- 

767. pi. 43 refs. 

3649 

Moore, A. E. THE DESTRUCTIVE EFFECT OF THE 

VIRUS OF RUSSIAN FAR EAST ENCEPHALITIS ON 

THE TRANSPLANTABLE MOUSE SARCOMA 

Cancer, N. Y., 1949, 2: 525-534. 

180. 

6 refs. 

The destruction of sarcoma 180 by the virus 

of Russian Far East encephalitis was always 

associated with infection and death of the 

animal. 

3650 


Moore, 

OF RUSSIAN 

A. E. ENHANCEMENTOF ONCOLYTICEFFECT 

ENCEPHALITIC VIRUS. Proc. Soc. 

The oncolytic effects of ê virus are closely 

connected with its neurotropic effects. By 

continuous tumor-to-tumor passage it has been 

possible to increase the oncolytic ability of 

the Russian encephalitis virus. Continuous 

brain-to-brain passage inhibited the oncolytic 

effect of the virus.



213 

VIRUSES. ENCEPHALITIS AND ENCEPHALOMYELITIS 

(Continued) 

3651 

Moore, A. E. INHIBITION OF GROWTH OF FIVE 

TRANSPLANTABLE MOUSE TUMORS BY THE VIRUS OF 

RUSSIAN FAR EAST ENCEPHALITIS. Cancer, N. Y,, 


Biol. 

"Five 

Ã„bstr., Bait., 

transplantable 

1951, 

mouse 

25: No. 27905. 

Tfumors of different 

histological types have been shown by histological 

and bioassay technics to be completely 

destroyed during the course of infection of 

the host animal 

encephalitis." 

with the virus of Russian 

3652 

Moore, A. E. and O'Connor. S. FURTHER STUDIES 

ON THE DESTRUCTIVE EFFECT OF THE VIRUS OF 

RUSSIAN FAR EAST ENCEPHALITIS ON THE TRANS 

PLANTABLE MOUSE SARCOMA 180. Cancer, N. Y., 



It was not possible to prevent the encepha 

litis and to maintain the tumor destroying 

ability of the virus. 

36! harpless, G. R., Davies. M. C. and Cox, H. R. 

ANTAGONISTIC ACTION OF CERTAIN NEUROTROPIC 

VIRUSES TOWARDS A LYMPHOID TUMOR IN CHICKENS. 

Proc. Soc. Exp. Biol., N.Y., 1950, 73: 270- 

275. 23 refs. Abstracted in: Excerpta raed., 

Sect. 5, 1950, 3: No. 3147. "RSS virus ob 

tained from infected RPL-12 tumor has a high 

oncolytic action when introduced either in 

the tumor area or at a distance from the 

tumor B" 

3654 

Southam, C. M., Bronstein, B. and Webber, L. F. 

EFFECT OF WEST NILE AND ILHEUS 

MOUSE LEUKEMIAS. Cancer Res., 

VIRUSES ON 

1951, 11: 669- 

675. 11 refs. Mice of the Akm strain bearing 

Ak4, Ak4R or Ak9421 leukemia were used. West 

Nile or Ilheus viruses temporarily inhibited 

leukemic leukocytosis and infiltration but 

did not increase the survival time of the 

mice. 

See 

3632 3633 

VIRUSES. 

INFLUENZA 

3655 

Kausche, G. A., LandschUtz, C. and Sauthoff, R. 

DIE BEEINFLUSSUNG DES ASCITES-TUMORS DER 

MAUS DURCH PR 8-INFLUENZA-VIRUS. [THE IN 

FLUENCE OF PR-8 INFLUENZA VIRUS ON ASCITES 

TUMOR OF THE MOUSE.] Zschr. Naturforsch., 

1952, 7b: 33-36. 9 refs. Abstracted in: 

Chem. A~6str., 1952, 46_: 104041. 

3656 

Moore, A. E. EFFECT OF INOCULATION OF THE VIRUSES 

OF INFLUENZA A AND HERPES SIMPLEX ON THE GROWTH 

OF TRANSPLANTABLE 

1949, 2: 516-524. 

TUMORS IN MICE. Cancer, N. Y. , 

25 refs. Influenza A virus 

and heFpes simplex virus had no effect on the 

growth of tumor. 

3657 lloore, A. E. and Diamond, L. C. FACTORS IN 

FLUENCING THE EFFECT OF HEMAGGLUTINATING 

VIRUSES 

Immun., 

ON TUMOR CELL SUSPENSIONS. J. 

1953, 71: 441-445. 11 refs. Ab 


2: No. 4347. 

3658 Wagner, R. R. INFLUENZA VIRUS INFECTION OF 

TRANSPLANTED TUMORS. I. MULTIPLICATION OF 

A NEUROTROPIC STRAIN AND ITS EFFECT ON SOLID 

NEOPLASMS. Cancer Res., 1954, 14: 377-385. 

23 refs. 

3659 Wagner, R. R. INFLUENZA VIRUS INFECTION OF 

TRANSPLANTED TUMORS. II. THE RELATION OF 

HOST IMMUNITY TO VIRUS ACTION. J. Immun., 

1955, 74: 439-445. 9 refs. 

3660 

Wagner, R. R. INFLUENZA VIRUS INFECTION OF 

TRANSPLANTED TUMORS. III. EFFECT OF PASSIVE 

IMMUNIZATION ON 

ASCITES TUMOR. 

INFECTIONS 

J. Immun., 

OF THE EHRLICH 

1955, 74: 446-454. 

26 refs. 

VIRUSES. 

VACCINIA 

3661 

Grai^ly, R. de, Moncourier and Biraben. BASTE Ã‰PI- 

THELÃ•OMA ULCEREUX DU COU FREINE ET LEGEREMENT 

EN REGRESSION SOUS L'INFLUENCE DU VIRUS VAC 

CINAL. [LARGE ULCERATING EPITHILIOMA OF THE 

NECK ARRESTED AND SHOWING SLIGHT REGRESSION 

UNDER TREATMENT BY VIRUS VACCINE.] J. med 

Bordeaux, 1948, 125: 458. Short report. 

3662 

Kritzler, R. A., Mulliken, B. and Turner, J. C. 

HISTOLOGICAL APPEARANCE OF MOUSE SARCOMA 180 

INFECTED BY VACCINIA VIRUS. Cancer Res., 

1949, 9: 74-75. 7 refs. "Transplants in 

mice of"mouse sarcoma 180, parasitized by 

vaccinia virus and found to grow less well 

than control transplants, revealed no 

Guanieri or.elementary bodies in the tumor 

cells or surrounding stroma...The differences 

observed between infected and noninfected 

tumors were quantitative rather than quali 

tative. Mitotic figures in infected tumors 

were fewer than in control tumors during 

the first 10 days after transplant. Varia 

tions in differentiation occurred in control 

and infected tumors but were more common in 

the latter." 

3663 Turner, J. C. and Mulliken, B. EFFECT OF THE 

INTRAVENOUS INJECTION OF VACCINIA VIRUS ON 

THE SURVIVAL OF MICE WITH A TRANSMISSIBLE 

LEUKEMIA. J. Clin. Invest., 1949 28- 815- 

816. An abstract. 

3664 

Turner, J. C. and Mulliken, B. EFFECTS OF INTRA 

VENOUS VACCINIA IN MICE WITH SARCOMA 180 OR 

LEUKEMIA 9417. Cancer,N. Y., 1950, 3: 354- 

360. 11 refs. 

3665 

Turner, J. C. and Mulliken, B. PARASITIZATION 

OF MOUSE SARCOMA 180 BY VACCINE VIRUS AND 

ITS EFFECT ON TUMOR GROWTH. Cancer Res. 

1947, 7: 774-778. 12 refs. 

3666 

Turner, J. C., Mulliken, B. and Kritzler, R. A. 

INFLUENCE OF VACCINE VIRUS ON A TRANSMISSIBLE 

LEUKEMIA OF MICE. 

1948, 69: 304-306. 

Proc. Soc. Exp. Biol., N. 


Y., 

Biol. JWstr., Bait., 1949, 23: No. 15866. 

VISCUM ALBUM 

see MISTLETOE 

VCTAMNS. 

A 

3667 

Geipel, K. KRITISCHE BEMERKUNGEN ZUR HYPER- 

VITAMINISIERUNGSTHERAPIE MALIGNER TUMOREN 

MIT VITAMIN A. [CRITICAL REMARKS ON THE 

HYPERVITAMINOSIS THERAPY OF MALIGNANT TU 

MORS WITH VITAMIN A.] Med. Klin., 

1955, 5J): 782-783. 29 refs. 

Beri., 

3668 

Â»Kleine, H. O. and Huber, L. ZUR FRAGE DER HYPER- 

VITAMINISIERUNG MIT VITAMIN A UND VITAMIN C 

BEI INOPERABLEN KARZINOMEN NACH V. WENDT. 

[HYPERVITAMINIZATION WITH VITAMIN A AND C IN 

THE TREATMENT OF INOPERABLE CARCINUMATA AC 

CORDING TO V. WENDT.] Munch, med. Wschr., 

1954, 96: 367-370. Negative data.



214 

VITAMINS. 

A (Continued) 

3669 

Ries, J. and Blasiu, A. P. VITAMIN-A-THERAPIE 

DES KARZINOMS. 

NOMA.] Munch, 

[VITAMIN A THERAPY OF CARCI 

med. Wschr., 1952, 94: 2033- 

2036. 10 reÃs. Vitamin A had no ÃªTfect on 

tumors in the 20 patients treated. 

3670 Schneider, E. EIN BEITRAG ZUR HYPERVITAMINI- 

SIERUNGSTHERAPIE DER KREBSKRANKEN. [VITA 

MINS C AND A IN CARCINOMA. CONTRIBUTION TO 

THE TREATMENT BY VITAMIN OVERDOSAGE.] Deut. 

med. Wschr., 1954, 79:584-589. 29refs. 

VITAMINS. B OR B COMPLEX â€”¿ EFFECT 

3671 Koczocik-Przedpelska, J. WPLYW ZESPOLU WITAIHINY 

B NA RAKA PRZESZCZEPIALNEGO EPITHELIOMA GUERIN. 

[THE EFFECT OF VITAMIN B COMPLEX ON THE TRANS 

PLANTED GUERIN EPITHELIOMA.] Acta physiol. 

polon., 1954, 5: 233. Vitamin B, promoted 

tumor growth; vitamin 82 had no effect and 

vitamin B complex consisting of 2.14y Hi, 

358y B'Â¿,1.428y Be and 3.571y PP, inhibited 

tumor growth as well as reduced mÃ©tastases. 

36Icott, G. M. RESISTANCE TO TUMOUR GROWTH IN 

RATS FED ON VITAMIN-B COMPLEX. Lancet, Lond., 

1949, 1.:102-104. 3 refs. "In many cases 

the tumours in the rats on vitamin-B complex 

eventually disappeared, and the average volume 

about three weeks after inoculation was often 

less than a quarter 

mours in controls." 

of the volume of the tu 

VITAMINS. 

B2 

see RIBOFLAVINE 

VITAMINS. 

Bl2 

3672a 

Barnard, R. D. PARENTERAL 

KEMIA (Correspondence). 

B12 IN ACUTE 

'Brit. M. J. 

LEU 

1953, 160-161. The author refers to 

Dr. Jan Welsh's article in Brit. M. J., 

1952, 2:1133 and sets forth reasons why 

he believes the B12 treatment to be in 

effective and in patients with anemia of 

the erythroblastic arrest type even harm 

ful. He describes treatment with terramycin 

milk and cortisone with which an 

average life duration, about 4 times that 

reported by Dr. Welsh, was obtained. 

3673 

Barnard, R. D. and Appel, A. SCLERODERMA ASSO 

CIATED WITH MALIGNANT ESTRAPENIC LEUKOBLASTO- 

SIS("LEUKEMIA"); CASE REPORT ILLUSTRATING 

THERAPEUTIC RESPONSE TO ORALLY ADMINISTERED 

CRUDE "B" FERMENTATION CONCENTRATES. Urol. 

Cut. Rev., 1950, 54: 345-348. 12 refs. 

3674 oris, E. and Murtas, L. MANCATA AZIONE DELLA 

VITAMINE B12 SULL'ACCRESCIMENTO DI INNESTI DI 

CARCINOSARCOMA 

VITAMIN Bi2 ON 

DI WALKER. [LACK 

GROWTH OF GRAFTED 

OF EFFECT OF 

WALKER CARCI- 

NOSARCOMAS.] Rass. med. sarda, 1953, 55: 56- 

58. Vitamin Bi2 inhibited growth of Walker 

carcinosarcoma in 2 mice and had no effect on 

3 mice. 

36Hohenadel, B. EINIGE VERSUCHE ÃœBER DEN EINFLUSS 

DES VITAMINS Bl2 AUF VERSCHIEDENE ZELLARTEN 

IN VITRO. [EXPERIMENTS ON THE EFFECT OF VITA 

MIN B12 ON DIFFERENT KINDS OF CELLS IN VITRO.] 

Aerztl. Forsch., 1954, 8: 1/58-1/65. 17 refs. 

3676 Welsh, I. FAILURE OF MASSIVE DOSES OF VITAMIN 

Bl2 IN ACUTE LEUKAEMIA. Brit. M. J., 1952, 

2:1133. 2 refs. Although 6 patients had a 

partial short remission, there was no evi 

dence that the addition of vitamin B\2 

altered the course of the disease. 

See 

1409 1665 2074 2679 3500 

VITAMINS. 

Bi4 

3677 Norris, E. R. and Majnarich, J. J. VITAMIN B14 

AND 32-33. CELL 7PROLIFERATION. refs. Abstracted Science. in: Excerpta~He"d. 1949, 109: . 

Sect. 2, 1949, 2: No. 5080; Chem. Abstr., 1949, 

Â«: 9195ÃŒ. 

VITAMINS. 

C 

see ASCORBIC 

VITAMINS. D. 

ACID 

3678 

Desmonts, T. L'ACTION DE LA VITAMINE D2 AU 

COURS DE LA LEUCEMIE LYMPHOIDE ET DU LYMPHO- 

SARCOME. [EFFECT OF TREATMENT OF VITAMIN D2 

IN LYMPHOID LEUKEMIA AND LYMPHOSARCOMA â€ž¿ ] 

Sang, Par., 1948, 1Â£: 125-126. One patient 

with lymphoid leukemia resistant to x-ray 

treatment received 15 mg daily of vitamin 

D by mouth for 5 weeks. The dose was in 

creased to 30 mg daily for the next 6 weeks. 

Following a relapse due to interruption of 

therapy, administration of the drug was 

continued in doses of 15 mg daily. The 

treatment caused a decrease in the leucocyte 

count. A similar course of treatment was 

given with good results to a patient with 

lymphosarcoma. 

36Sesmonts, T. ACTION FAVORABLE DE LA VITAMINE 

D DANS L'ERYTHRODERMIE LEUCEMIQUE ET LA 

MALADIE DE HODGKIN. [FAVORABLE EFFECT OF 

VITAMIN D IN THE TREATMENT OF LEUKEMIC 

ERYTHRODERMA AND HODGKIN'S DISEASE.] Rev. 

path. coznpâ€ž,Par., 1951, 51: 161-164. 

6 refs. Treatment in 4 cases of Hodgkin's 

disease is reported which resulted in fa 

vorable modification of the blood picture 

and which caused prolongation of the life 

of a patient whose case seemed hopeless at 

the beginning of the vitamine therapy. 

3680 

Desmonts, T., Duelos, M. and Dalmau. ACTION 

FAVORABLE DE LA VITAMINE D SUR L'Ã‰VOLUTION 

D'UN CAS DE MALADIE DE HODGKIN. [FAVORABLE 

EFFECT OF VITAMIN 

CASE OF HODGKIN'S 

D ON THE EVOLUTION OF A 

DISEASE.] Sang, Par., 

1951, 22: 74-75. 1 rÃ©f. 

VITAMINS. 

D2 

3681 

Desmonts., T. 

LYMPHOIDE. 

ERYTHRODERMIE 

ECHEC PARTIEL 

ET LEUCÃ‰MIE 

DE LA RADIOTHÃ‰RA 

PIE; ACTION DE LA VITAMINE D2 ET DE L'OPO- 

THERAPIE MEDULLAIRE. [ERYTHRODERMA AND LYM- 

PHOID LEUKEMIA. PARTIAL FAILURE OF RADIO 

THERAPY; EFFECT OF VIT.AMIN O2 AND MEDULLAR 

OPOTHERAPY.] Paris med., 1947, 37: 590-591. 

Abstracted in: Index analyt. canceY., Par. 

1948, 19: No. 263. 

3682 

PirilÃ¤, P. OBSERVATIONS ON THE FAVOURABLE EF 

FECT OF CALCIFEROL (VITAMIN D2) ON THE 

CHANGES IN THE BLOOD PICTURE AS WELL AS IN 

THE SKIN IN A CASE OF CHRONIC LYMPHATIC LEU 

KEMIA. Acta derm, 

1952, 29: 275-279. 

vener. Suppl., 

4 refs. 

Stockh., 

VTTAMENS. E â€”¿ EFFSCT 

3683 RÃ©bert, A. F. LES VITAMINES E ET K ET L'INOSI- 

TOL DANS LE TRAITEMENT DES CARCINOMES DE LA 

TOMATE. [VITAMINS E AND K AND INOSITOL IN 

THE TREATMENT OF CANCER OF THE TOMATO.] Rev. 

path, comp., Par., 1952, 52: 275-278. 15 refs



215 

VITAMINS. 

H' 

see BENZOIC ACID, p-AMINO 

VITAMINS. K. 

See 

3816 

VITAMINS. 

see 

VITAMINS. 

K3 

MENADIONE 

PANVITAMIN LAPKITE 

36Furtado Dias, M. T. LE RÃ”LE DE CERTAINS 

FACTEURSALIMENTAIRESDANS LE CANCER. I. 

LES VITAMINS. [THE PART PLAYEDBY SOME 

NUTRITIONAL FACTORS IN CASES OF CANCER. I. 

THE VITAMINS]. Arq. Pat., 1950, 22: 242-264. 

Appro*. 100 reÃs. Abstracted In: Excerpta 

med., Sect. 5, 1952, 5: No. 2707. 

VITAMINS. M. 

see 

VITAMINS. 

FOLIC ACID 

PP 

see NICOTINIC ACID 

VITAMINS. R. 

36lygh, 0. EFFETS DE LA VITAMINE R SUR LE CANCER 

MAMMAIRECHEZ LES SOURIS. [EFFECTS OF VITAMIN 

R ON MAMMARYCANCERIN MICE.] Bull. Soc. chim. 

biol., Par., 1951, 33: 833-839. Abstracted 


XANTHONE, l-DIETHYLAMINOETHYLAMINO-4- 

METHYLTHIO- 

Hackmann, C.. GÃnnert, R. and Mausz, H. UNTER 

SUCHUNGEN ÃœBER DIE TUMORHEMMENDE WIRKUNG DES 

MIRACILS. [STUDIES ON THE TUMOR-INHIBITING 

EFFECT OF MIRACIL]. Naturwissenschaften, 

1949, 36: 29. 4 refs. Abstracted in: Chen. 

Abstr.~1950, 44: No. 41371. 

3687 

Lang, K., Siebert, G. and LÃnnecke, W. ÃœBER 

BIOCHEMISCHE WIRKUNGEN VON MIRACIL D. [BIO 

CHEMICAL EFFECTS OF MIRACIL D]. Klin. Wschr., 

1950, 

Chem. 

28: 104-105. 

A"Estr., 1950, 


44: 8973b. 

in: 

XANTHOPTERIN 

3688 

Albrecht, M. UNTERSUCHUNGEN ÃœBERDIE EINWIR 

KUNG VON XANTHOPTERIN AUF MENSCHLICHES 

KNOCHENMARKIN VITRO. [EXPERIMENTS ON THE 

ACTION OF XANTHOPTERIN ON HUMANBONE MARROW 

IN VITRO]. Aerztl. Wschr., 1950, 5: 878-880. 


45: No. 4353e. 

3689 Lang, K., Siebert, G. and Brenner, I. ÃœBER DIE 

BEEINFLUSSUNG DER DESOXYRIBONUCLEOTIDASE DURCH 

XANTHOPTERIN. [INFLUENCE OF XANTHOPTERIN ON 

DESOXYRIBONUCLEOTIDASE.] Klin. Wschr., 1950, 

28: 105. 4 refs. Xanthopterin is shown to 

Increase dephosphorylation of desoxyribonucleotides. 

It is suggested that its influence on 

cell division is due to this phenomenon. 

3690 Norris, E. R. and Majnarich, J. J. EFFECT OF 

PTERIDINES AND BLOOD SERUM ON NEOPLASTIC CELL 

CULTURE IN VITRO. Am. J. Physiol., 1948, 

153: 492-495. 

3691 

Norris, E. R. and Majnarich, J. J. FURTHER 

STUDIES ON XANTHOPTERIN AND OTHER PTERIDINES 

IN BONE MARROW CULTURES. Am. J. Physiol., 1948, 

152:652-657. 

See 

252 762 

YEASTS 

1007 1775 

3692 

Audier, A. G. CHEMOTHERAPY OF CARCINOMA IM 

PROVED BY HOST CONDITIONING. II. LOCAL 

CHEMOTHERAPY COMBINED WITH INDIRECT TREAT 

MENT. Antonie van Leeuwenhoek, Amst., 


1954, 


Yeast-extract injected in the outer margin 

of the tumor combined with oral administration 

of the same extract destroyed tumor cells and 

prevented mÃ©tastases. 

3693 

Bayerle, H., Stickler, G. and Kottmeier, P. 

ZUR FRAGE DER HEMMUNG DES MALIGNEN WACHSTUMS 

DURCH LEBENDE HEFEN. [ON THE INHIBITING EF 

FECT OF MALIGNANT GROWTH WITH YEAST.] Zschr. 


A suspension of SaccÃ¯Ã¯aVomycescerevisiae given 

intravenously in doses of 5 cm3 to guinea pigs 

with Jensen sarcoma, 

Brown-Pearce sarcoma 

ascite 

showed 

carcinoma 

no effect 

and 

upon 

these tumors, but did slightly damage the 

cancer cells. The yeast injections had no 

effect upon human cancer tissue in vitro, 

either. 

3694 Castelli, V. and Gaggini. AZIONI LITICHE 'IN 

VITRO1 DI ALCUNI SACCAROMICETI SU CELLULE 

NEOPLASTICHE. [THE LYTIC ACTION IN VITRO OF 

SOME SACCHAROMYCES ON TUMOR CELLS.] Schweiz. 

Zschr. Path. Bakt., 1947, 10: 419-425. 

3695 

Gottschalk, F. EINE BIOLOGISCHE BEHANDLUNG DES 

KREBSKRANKEN ORGANISMUS UNTER BESONDERER 

BERÃœCKSICHTIGUNG DER HEFETHERAPIE. [BIOLOGI- 

CAN TREATMENT OF CANCEROUS ORGANISM WITH 

SPECIAL CONSIDERATION OF YEAST TREATMENT.] 

Manch, med. Wschr., 1951, 93: 1708-1709. 

A solution of yeast cells In"concentration 

of 40 million per cc given in injections of 

0.25 cc-1 cc caused subjective and objective 

improvements and even complete remission in 

various cases of tumors. The action of 

yeast is not known, but is assumed to be 

specific; the injections caused leucocytosis 

and lymphocytosis. 

3696 

Cusso, A. ESPERIMENTI DE LISI CELLULARI OTTENUTE 

CON LIEVITI. [EXPERIMENTS ON CELL LYSIS WITH 

YEASTS]. Boll. Soc. ital. biol. sper., 1947, 

23: 609-612. 

3697 

Cusso, A. SUL COMPORTAMENTO DELLA CELLULA NEO- 

PLASTICA IN PRESENZA DI LIEVITO. [BEHAVIOR 

OF NEOPLASTIC CELL IN THE PRESENCE OF YEAST] . 

Riv. ostet., Milano, 1952, 34: 339-342. 13 refs. 

36Lund, H. THE CYTOTOXIC ACTION IN VITRO AND 

IN VIVO OF LIPID-CONTAINING AND LIPID-FREE 

PROTEOSE. THE TOXICITY OF PROTEIN HYDROLY- 

SATE OF SACCHAROMYCES CEREVISIAE! Acta path, 

microb. scand., 1953, 33:80-85.



216 

YEASTS (Continued) 

3699 

Pretti, G. ACTION D'ANTAGONISME DE LA LEVURE 

SUR LES CELLULES NEOPLASIQUES. [ANTAGONISTIC 

ACTION OF YEAST ON NEOPLASTIC CELLS.] Acta 

UniÃ³ internat, 

514. "We have 

cancr., Louvain, 1951, 

examined the behaviour 

7: 

of 

512- 

in 

vitro cultures of neoplastic epithelial cells 

when yeast suspensions were added to the trans 

plantation. Several hundreds of these exami 

nations demonstrated an antagonistic activity 

of yeast specific for neoplastic cells. Al 

though the former cultures were blocked by 

yeast, we observed no action of yeast suspension 

on in vitro cultures 

fibroblasts." 

of normal epithelium and 

3700 Protti, G. L'ANTAGONISMO DEI LIEVITI VERSO LA 

CELLULA NEOPLÃ•STICA OSSERVATO NELLE COLTURE 

IN VITRO. [THE ANTAGONISTIC ACTION OF YEAST 

ON THE NEOPLASTIC CELL CULTURE IN VITRO 1 

Tumori, Milano, 1950, 24: 14-24. tab. 2 refs 

Abstracted in: Biol. AbTtr., Bait., 1951 25- 

No. 23833. Eumycetes extract inhibited mitosis 

of neoplastic cells in vitro 

3701 Protti, G. AZIONI DI ANTAGONISMO PRODOTTE DA 

LIEVITI SULLA CELLULA NEOPLÃ•STICA. [ANTAGO 

NISTIC EFFECTS CAUSED BY YEASTS ON THE NEO 

PLASTIC CELL.] Tumori, MilanÂ«. 1948 22' 

222-229. 11 refs. Abstracted in: ExceTFpta 

med., Sect. 5, 1949, 2: No. 2889. 

3702 Protti, G. LE AZIONI DI ANTAGONISMO PRODOTTE DA 

LIEVITI SULLA CELLULA NEOPLÃ•STICA OSSERVATE 

COLLA REAZIONE CITOCHIMICA DEL FEULGEN [ANTA 

GONISTIC 

OBSERVED 

ACTIONS OF YEASTS ON NEOPLASTIC CELLS 

BY THE FEULGEN REACTIâ„¢ Ã•Ã•mori ' 

Milano, 1949, 23: 156-164. 

m Exce?:pta Â»Â«a-.,Sect. 5, 


1950, 3: No. 1116. 

"The nuclei of the tumour cells show after 

such treatment with yeasts, a diminution of 

their thymonucleic acid content..." - Excerpta 

D16Q. 

3703 Protti, G. SUL FENOMENO DELLA "CITOFOTOLISI " 

[THE PHENOMENON OF "CYTOPHOTOLYSIS "1 

Pathologica, Genova, 1946, 38: 147-151. 

t 

See 

161 1063 1690 

YUCCA ROOTS - EFFECT ON EXPERIMENTAL TUMORS 

See 

926 

ZINC 

3704 

Plaen, P. de, Lion, G., van Male de Ghorain n 

Â«Iri^?LL'INFLUENCE DES SELS DE ZINC ET 

^n^roÃ¼* LE SANGDES Â«ALADESCANCÃ‰REUX 

IRRADIES [STUDY ON THE INFLUENCEOF ZINC 

2â„¢râ„¢Gâ„¢SIUMS*VT Â°NTHE BLOODOF IRRADIATED 

CANCERPATIENTS.] J. radiol. 

34: 762-768. No antitumoral 

electr., 

effect 

1953 

of the 

zinc and magnesium salt injections alone 

in conjunction with x-rays was observed 

and 

See 

139 1809

CANCER CHEMOTHERAPY ACENAPHTHENE ... - Cancer Research

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