20110720_S3-LL Polytrauma DGU_final_eng_cleaned_mc_korrigiert
20110720_S3-LL Polytrauma DGU_final_eng_cleaned_mc_korrigiert
20110720_S3-LL Polytrauma DGU_final_eng_cleaned_mc_korrigiert
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
<strong>S3</strong> – Guideline<br />
on Treatment of Patients with<br />
Severe and Multiple Injuries<br />
English Version of the German Guideline <strong>S3</strong> – Leitlinie <strong>Polytrauma</strong>/Schwerverletzten-Behandlung<br />
(AWMF-Registry No. 012/019)<br />
Publisher: German Trauma Society (<strong>DGU</strong>) (lead)<br />
Office in Langenbeck-Virchow House<br />
Luisenstr. 58/59<br />
10117 Berlin<br />
German Society of General and Visceral Surgery<br />
German Society of Anesthesiology and Intensive Care Medicine<br />
German Society of Endovascular and Vascular Surgery<br />
German Society of Hand Surgery<br />
German Society of Oto-Rhino-Laryngology, Head and Neck Surgery<br />
German Society of Oral and Maxillofacial Surgery<br />
German Society of Neurosurgery<br />
German Society of Thoracic Surgery<br />
German Society of Urology<br />
German Radiology Society<br />
Addresses for correspondence: Prof. Dr. Klaus Michael Stürmer<br />
Head of the Guidelines Committee at the <strong>DGU</strong><br />
Director of the Clinic for Trauma Surgery, Plastic and Reconstructive<br />
Surgery<br />
University Hospital Göttingen – Georg-August-Universität<br />
Robert-Koch Str. 40<br />
37075 Göttingen<br />
Prof. Dr. Prof. h.c. Edmund Neugebauer<br />
Head of the Steering Group for the <strong>S3</strong> Guideline on <strong>Polytrauma</strong><br />
Chair of Surgical Research<br />
Institute for Research in Operative Medicine (IFOM)<br />
University of Witten, Herdecke<br />
Ostmerheimerstr. 200<br />
51109 Cologne
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Overall coordination<br />
Prof. Dr. rer. nat. Prof. h.c. Edmund Neugebauer<br />
Institute for Research in Operative Medicine (IFOM)<br />
University of Witten, Herdecke<br />
Ostmerheimerstr. 200<br />
51109 Cologne<br />
Coordination of sections<br />
Prehospital<br />
Prof. Dr. med. Christian Waydhas<br />
University Hospital Essen<br />
Clinic for Trauma Surgery<br />
Hufelandstr. 55<br />
45147 Essen<br />
Emergency room<br />
PD Dr. med. Sven Lendemans<br />
University Hospital Essen<br />
Clinic for Trauma Surgery<br />
Hufelandstr. 55<br />
45147 Essen<br />
Emergency surgery phase<br />
Prof. Dr. med. Bertil Bouillon<br />
Cologne City Hospitals gGmbH<br />
Merheim Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Sports Injuries<br />
51058 Cologne<br />
Prof. Dr. med. Steffen Ruchholtz<br />
University Hospital Giessen/Marburg<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Baldingerstrasse<br />
35043 Marburg<br />
Prof. Dr. med. Dieter Rixen<br />
Clinic for Trauma Surgery & Orthopedics<br />
BG Trauma Hospital Duisburg<br />
Grossenbaumer Allee 250<br />
47249 Duisburg<br />
- ii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Organization, methods advice and support<br />
Dr. med. Michaela Eikermann (from 07/2010)<br />
Institute for Research in Operative Medicine<br />
(IFOM)<br />
University of Witten, Herdecke<br />
Ostmerheimerstr. 200<br />
51109 Cologne<br />
Christoph Mosch<br />
Institute for Research in Operative Medicine<br />
(IFOM)<br />
University of Witten, Herdecke<br />
Ostmerheimerstr. 200<br />
51109 Cologne<br />
Ulrike Nienaber<br />
Institute for Research in Operative Medicine<br />
(IFOM)<br />
University of Witten, Herdecke<br />
Ostmerheimerstr. 200<br />
51109 Cologne<br />
PD Dr. med. Stefan Sauerland (until 12/2009)<br />
Institute for Research in Operative Medicine<br />
(IFOM)<br />
University of Witten, Herdecke<br />
Ostmerheimerstr. 200<br />
51109 Cologne<br />
Dr. med. Martin Schenkel<br />
Cologne City Hospitals gGmbH<br />
Merheim Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Sports Injuries<br />
51058 Cologne<br />
Maren Walgenbach<br />
Institute for Research in Operative Medicine<br />
(IFOM)<br />
University of Witten, Herdecke<br />
Ostmerheimerstr. 200<br />
51109 Cologne<br />
- iii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Medical societies and their delegates who participated in the consensus process<br />
Dr. med. Michael Bernhard<br />
(German Society of Anesthesiology and<br />
Intensive Care Medicine)<br />
Fulda Hospital gAG<br />
Central Accident & Emergency<br />
Pacelliallee 4<br />
36043 Fulda<br />
Prof. Dr. med. Bernd W. Böttiger<br />
(German Society of Anesthesiology and<br />
Intensive Care Medicine)<br />
University Hospital Cologne<br />
Clinic for Anesthesiology and Operative<br />
Intensive Care<br />
Kerpener Str. 62<br />
50937 Cologne<br />
Prof. Dr. med. Thomas Bürger<br />
(German Society of Endovascular and Vascular<br />
Surgery)<br />
Kurhessisches Diakonissenhaus<br />
Department of Vascular Surgery<br />
Goethestr. 85<br />
34119 Kassel<br />
Prof. Dr. med. Matthias Fischer<br />
(German Society of Anesthesiology and<br />
Intensive Care Medicine)<br />
Klinik am Eichert Göppingen<br />
Clinic for Anesthesiology and Operative<br />
Intensive Care, Emergency Treatment & Pain<br />
Therapy<br />
Eichertstr. 3<br />
73035 Göppingen<br />
Prof. Dr. med. Dr. med. dent. Ralf Gutwald<br />
(German Society of Oral and Maxillofacial<br />
Surgery)<br />
University Hospital Freiburg<br />
Clinic for Oral and Maxillofacial Surgery<br />
Hugstetterstr. 55<br />
79106 Freiburg<br />
Prof. Dr. med. Markus Hohenfellner<br />
(German Society of Urology)<br />
University Hospital Heidelberg<br />
Urology Clinic<br />
Im Neuenheimer Feld 110<br />
69120 Heidelberg<br />
Prof. Dr. med. Ernst Klar<br />
(German Society of General and Visceral<br />
Surgery)<br />
University Hospital Rostock<br />
Department of General, Thoracic, Vascular &<br />
Transplantation Surgery<br />
Schillingallee 35<br />
18055 Rostock<br />
Prof. Dr. med. Eckhard Rickels<br />
(German Society of Neurosurgery)<br />
Celle General Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Neurotraumatology<br />
Siemensplatz 4<br />
29223 Celle<br />
Prof. Dr. med. Jürgen Schüttler<br />
(German Society of Anesthesiology and<br />
Intensive Care Medicine)<br />
University Hospital Erlangen<br />
Clinic for Anesthesiology<br />
Krankenhausstr. 12<br />
91054 Erlangen<br />
Prof. Dr. med. Andreas Seekamp<br />
(German Trauma Society)<br />
University Hospital Schleswig-Holstein (Kiel<br />
Campus)<br />
Clinic for Trauma Surgery<br />
Arnold-Heller-Str. 7<br />
24105 Kiel<br />
Prof. Dr. med. Klaus Michael Stürmer<br />
(German Trauma Society)<br />
University Hospital Göttingen – Georg-<br />
August University<br />
Department of Trauma Surgery, Plastic and Reconstructive<br />
Surgery<br />
Robert-Koch Str. 40<br />
37075 Göttingen<br />
Prof. Dr. med. Lothar Swoboda<br />
German Society of Thoracic Surgery<br />
Eissendorfer Pferdeweg 17a<br />
21075 Hamburg<br />
- iv -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Prof. Dr. med. Thomas J. Vogl<br />
(German Radiology Society)<br />
University Hospital Frankfurt<br />
Institute of Diagnostic & Interventional<br />
Radiology<br />
Theodor-Stern-Kai 7<br />
60590 Frankfurt/Main<br />
Dr. med. Frank Waldfahrer<br />
(German Society of Oto-Rhino-Laryngology,<br />
Head and Neck Surgery)<br />
University Hospital Erlangen<br />
Oto-Rhino-Laryngology Clinic<br />
Waldstrasse 1<br />
91054 Erlangen<br />
Prof. Dr. med. Margot Wüstner-Hofmann<br />
(German Society of Hand Surgery)<br />
Klinik Ros<strong>eng</strong>asse GmbH<br />
Ros<strong>eng</strong>asse 19<br />
89073 Ulm/Donau<br />
- v -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Authors/co-authors of individual chapters<br />
Dr. med. MSc. Ulf Aschenbrenner<br />
University Hospital Dresden<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Fetscherstr. 74<br />
01307 Dresden<br />
Ch. 1.9, 2.15<br />
PD Dr. med. Hermann Bail<br />
South Nuremberg Hospital<br />
Clinic for Trauma & Orthopedic Surgery<br />
Breslauer Str. 201<br />
90471 Nuremberg<br />
Ch. 1.4, 1.7, 2.5<br />
Dr. med. Marc Banerjee<br />
Cologne City Hospitals gGmbH<br />
Merheim Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Sports Injuries<br />
51058 Cologne<br />
Ch. 3.10<br />
Dr. med. Mark Bardenheuer<br />
Landshut Hospital gGmbH<br />
Clinic for Orthopedics & Trauma Surgery<br />
Robert-Koch Str. 1<br />
84034 Landshut<br />
Ch. 1.4<br />
Dr. med. Christoph Bartl<br />
University Hospital Ulm<br />
Clinic for Trauma, Hand, Plastic &<br />
Reconstructive Surgery<br />
Steinhövelstr. 9<br />
89070 Ulm<br />
Ch. 3.2<br />
Dr. med. Michael Bayeff-Filloff<br />
Rosenheim Hospital<br />
Central Accident & Emergency<br />
Pettenkoferstr. 10<br />
83022 Rosenheim<br />
Ch. 1.4, 1.6, 2.10, 3.8<br />
Prof. Dr. med. Alexander Beck<br />
Juliusspital Würzburg<br />
Department of Orthopedics, Trauma &<br />
Reconstructive Surgery<br />
Juliuspromenade 19<br />
97070 Würzburg<br />
Ch. 1.4, 1.6, 1.10<br />
Dr. med. Michael Bernhard<br />
Fulda Hospital gAG<br />
Central Accident & Emergency<br />
Pacelliallee 4<br />
36043 Fulda<br />
Ch. 1.2, 2.15, 2.16<br />
PD Dr. med. Achim Biewener<br />
University Hospital Dresden<br />
Clinic for Trauma & Reconstructive Surgery<br />
Fetscherstr. 74<br />
01307 Dresden<br />
Ch. 1.4, 1.9<br />
Prof. Dr. med. Jochen Blum<br />
Worms Hospital<br />
Clinic for Trauma Surgery<br />
Gabriel-von-Seidl-Strasse 81<br />
67550 Worms<br />
Ch. 3.8<br />
Prof. Dr. med. Bernd W. Böttiger<br />
University Hospital Cologne<br />
Clinic for Anesthesiology and Operative<br />
Intensive Care<br />
Kerpener Str. 62<br />
50937 Cologne<br />
Ch. 1.2, 2.15, 2.16<br />
Prof. Dr. med. Bertil Bouillon<br />
Cologne City Hospitals gGmbH<br />
Merheim Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Sports Injuries<br />
51058 Cologne<br />
Ch. 1.4, 3.10<br />
- vi -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Dr. med. Jörg Braun<br />
DRF Stiftung Luftrettung gemeinnützige AG,<br />
Medical Division<br />
Rita-Maiburg-Str. 2<br />
70794 Filderstadt<br />
Ch. 1.9<br />
Prof. Dr. med. Volker Bühren<br />
BG Trauma Hospital Murnau<br />
Department of Trauma Surgery & Sports<br />
Orthopedics<br />
Prof. Küntscher-Str. 8<br />
82418 Murnau am Staffelsee<br />
Ch. 2.9, 3.7<br />
Dr. med. Markus Burkhardt<br />
University Hospital of the Sauerland<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Kirrberger Strasse 100<br />
66424 Homburg/Saar<br />
Ch. 2.7<br />
Prof. Dr. med. Klaus Dresing<br />
University Hospital Göttingen – Georg-<br />
August University<br />
Clinic for Trauma, Plastic & Reconstructive<br />
Surgery<br />
Robert-Koch Str. 40<br />
37075 Göttingen<br />
Ch. 2.2<br />
Prof. Dr. med. Axel Ekkernkamp<br />
Trauma Hospital Berlin<br />
Clinic for Trauma Surgery & Orthopedics<br />
Warener Str. 7<br />
12683 Berlin<br />
Ch. 3.3, 3.4<br />
Christian Fiebig<br />
University Hospital Frankfurt<br />
Institute of Diagnostic & Interventional<br />
Radiology<br />
Theodor-Stern-Kai 7<br />
60590 Frankfurt/Main<br />
Ch. 2.17<br />
Dr. med. Marc Fischbacher<br />
University Hospital Essen<br />
Clinic for Trauma Surgery<br />
Hufelandstr. 55<br />
45147 Essen<br />
Ch. 1.2, 1.4<br />
Prof. Dr. med. Markus Fischer<br />
ATOS Clinic Practice<br />
Bismarckstr. 9-15<br />
69115 Heidelberg<br />
Ch. 2.14<br />
Prof. Dr. med. Matthias Fischer<br />
Klinik am Eichert Göppingen<br />
Clinic for Anesthesiology and Operative<br />
Intensive Care, Emergency Treatment & Pain<br />
Therapy<br />
Eichertstr. 3<br />
73035 Göppingen<br />
Ch. 1.2, 2.15<br />
Dr. med. Mark D. Frank<br />
University Hospital Dresden<br />
Clinical for Anesthesiology & Intensive<br />
Treatment<br />
Fetscherstr. 74<br />
01307 Dresden<br />
Ch. 1.9<br />
Prof. Dr. med. Florian Gebhard<br />
University Hospital Ulm<br />
Clinic for Trauma, Hand, Plastic &<br />
Reconstructive Surgery<br />
Steinhövelstr. 9<br />
89070 Ulm<br />
Ch. 3.2<br />
Prof. Dr. med. Dr. med. dent. Ralf Gutwald<br />
University Hospital Freiburg<br />
Clinic for Oral and Maxillofacial Surgery<br />
Hugstetterstr. 55<br />
79106 Freiburg<br />
Ch. 2.13, 3.12<br />
Prof. Dr. med. Norbert P. Haas<br />
Charité – Campus Virchow Clinic<br />
Clinic for Trauma & Reconstructive Surgery<br />
Augustenburger Platz 1<br />
13353 Berlin<br />
Ch. 2.5<br />
Dr. med. Sebastian Hentsch<br />
German Federal Military Hospital Koblenz<br />
Department of Trauma & Reconstructive<br />
Surgery<br />
Rübenacher Str. 170<br />
56072 Koblenz<br />
Ch. 1.4<br />
- vii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Prof. Dr. med. Karl Hörmann<br />
University Hospital Mannheim<br />
Oto-Rhino-Laryngology Clinic<br />
Theodor-Kutzer-Ufer 1-3<br />
68167 Mannheim<br />
Ch. 2.14, 3.13<br />
Prof. Dr. med. Markus Hohenfellner<br />
University Hospital Heidelberg<br />
Urology Clinic<br />
Im Neuenheimer Feld 110<br />
69120 Heidelberg<br />
Ch. 1.8, 2.8, 3.6<br />
PD Dr. med. Dr. med. dent. Bettina<br />
Hohlweg-Majert<br />
University Hospital Freiburg<br />
Clinic for Oral and Maxillofacial Surgery<br />
Hugstetterstr. 55<br />
79106 Freiburg<br />
Ch. 2.13, 3.12<br />
Dr. med. Ewald Hüls<br />
Celle General Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Neurotraumatology<br />
Siemensplatz 4<br />
29223 Celle<br />
Ch. 1.4<br />
Dr. med. Björn Hußmann<br />
University Hospital Essen<br />
Clinic for Trauma Surgery<br />
Hufelandstr. 55<br />
45147 Essen<br />
Ch. 2.10<br />
Prof. Dr. med. Christoph Josten<br />
University Hospital Leipzig<br />
Clinic & Outpatient Clinic for Trauma &<br />
Reconstructive Surgery<br />
Liebigstr. 20<br />
04103 Leipzig<br />
Ch. 2.15<br />
PD Dr. med. Karl-Georg Kanz<br />
Munich University Hospital<br />
Surgery Clinic & Outpatient Clinic<br />
Nussbaumstr. 20<br />
80336 Munich<br />
Ch. 1.2, 1.4<br />
Prof. Dr. med. Lothar Kinzl<br />
University Hospital Ulm<br />
Clinic for Trauma, Hand, Plastic &<br />
Reconstructive Surgery<br />
Steinhövelstr. 9<br />
89070 Ulm<br />
Ch. 3.2<br />
Dr. med. Christian Kleber<br />
Charité – Campus Virchow Clinic<br />
Clinic for Trauma & Reconstructive Surgery<br />
Augustenburger Platz 1<br />
13353 Berlin<br />
Ch. 1.7<br />
Prof. Dr. med. Markus W. Knöferl<br />
University Hospital Ulm<br />
Clinic for Trauma, Hand, Plastic &<br />
Reconstructive Surgery<br />
Steinhövelstr. 9<br />
89070 Ulm<br />
Ch. 3.2<br />
PD Dr. med. Christian A. Kühne<br />
University Hospital Giessen/Marburg<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Baldingerstrasse<br />
35043 Marburg<br />
Ch. 2.2, 2.3<br />
Prof. Dr. med. Christian K. Lackner<br />
Munich University Hospital<br />
Institute for Emergency Medicine &<br />
Medicine Management<br />
Schillerstr. 53<br />
80336 Munich<br />
Ch. 1.4<br />
PD Dr. med. Sven Lendemans<br />
University Hospital Essen<br />
Clinic for Trauma Surgery<br />
Hufelandstr. 55<br />
45147 Essen<br />
Ch. 2.1, 2.10<br />
Dr. med. Dr. med. dent. Niels Liebehenschel<br />
University Hospital Freiburg<br />
Clinic for Oral and Maxillofacial Surgery<br />
Hugstetterstr. 55<br />
79106 Freiburg<br />
Ch. 2.13, 3.12<br />
- viii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
PD Dr. med. Ulrich C. Liener<br />
Marienhospital Stuttgart<br />
Clinic for Orthopedics & Trauma Surgery<br />
Böheimstr. 37<br />
70199 Stuttgart<br />
Ch. 3.2<br />
Dr. med. Heiko Lier<br />
University Hospital Cologne<br />
Clinic for Anesthesiology and Operative<br />
Intensive Care<br />
Kerpener Str. 62<br />
50937 Cologne<br />
Ch. 2.16<br />
Dr. med. Tobias Lindner<br />
Charité – Campus Virchow Clinic<br />
Clinic for Trauma & Reconstructive Surgery<br />
Augustenburger Platz 1<br />
13353 Berlin<br />
Ch. 1.7, 2.5<br />
Thomas H. Lynch<br />
St. James’s Hospital<br />
Trinity College<br />
James’s Street<br />
Dublin 8 (Ireland)<br />
Ch. 1.8, 2.8, 3.6<br />
Prof. Dr. med. Martin G. Mack<br />
University Hospital Frankfurt<br />
Institute of Diagnostic & Interventional<br />
Radiology<br />
Theodor-Stern-Kai 7<br />
60590 Frankfurt/Main<br />
Ch. 2.17<br />
Dipl.-Med. Ivan Marintschev<br />
University Hospital Jena<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Erlanger Allee 101<br />
07747 Jena<br />
Ch. 1.4<br />
PD Dr. med. Gerrit Matthes<br />
Trauma Hospital Berlin<br />
Clinic for Trauma Surgery & Orthopedics<br />
Warener Str. 7<br />
12683 Berlin<br />
Ch. 1.2, 1.4, 3.3, 3.4<br />
Dr. med. Hubert Mayer<br />
Surgical Group Practice am Vincentinum<br />
Franziskanergasse 14<br />
86152 Augsburg<br />
Ch. 1.4<br />
Dr. med. Yoram Mor<br />
Dept. of Urology<br />
The Chaim Sheba Medical Center<br />
Tel Hashomer, Ramat Gan, 52621 (Israel)<br />
Ch. 1.8, 2.8, 3.6<br />
Prof. Dr. med. Udo Obertacke<br />
University Hospital Mannheim<br />
Orthopedics Trauma Surgery Center<br />
Theodor-Kutzer-Ufer 1-3<br />
68167 Mannheim<br />
Ch. 2.4<br />
Prof. Dr. med. Hans-Jörg Oestern<br />
Celle General Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Neurotraumatology<br />
Siemensplatz 4<br />
29223 Celle<br />
Ch. 3.10<br />
Prof. Dr. med. Jesco Pfitzenmaier<br />
Protestant Hospital Bielefeld<br />
Clinic for Urology<br />
Schildescher Strasse 99<br />
33611 Bielefeld<br />
Ch. 1.8, 2.8, 3.6<br />
Luis Martínez-Piñeiro<br />
University Hospital La Paz<br />
Paseo de la Castellana, 261<br />
28046 Madrid (Spain)<br />
Ch. 1.8, 2.8, 3.6<br />
Eugen Plas<br />
City Hospital Lainz<br />
Wolkersbergenstrasse 1<br />
1130 Vienna (Austria)<br />
Ch. 1.8, 2.8, 3.6<br />
Prof. Dr. med. Tim Pohlemann<br />
University Hospital of the Sauerland<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Kirrberger Strasse 100<br />
66424 Homburg/Saar<br />
Ch. 2.7<br />
- ix -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
PD Dr. med. Stefan Rammelt<br />
University Hospital Dresden<br />
Clinic & Outpatient Clinic for Trauma &<br />
Reconstructive Surgery<br />
Fetscherstr. 74<br />
01307 Dresden<br />
Ch. 2.12, 3.11<br />
Dr. med. Marcus Raum<br />
Helios Clinic Siegburg<br />
Department of Orthopedics & Traumatology<br />
Ringstr. 49<br />
53721 Siegburg<br />
Ch. 1.3, 1.4<br />
Prof. Dr. med. Gerd Regel<br />
Rosenheim Hospital<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Pettenkoferstr. 10<br />
83022 Rosenheim<br />
Ch. 2.10<br />
Dr. med. Alexander Reske<br />
University Hospital Dresden<br />
Clinic & Outpatient Clinic for<br />
Anesthesiology & Intensive Treatment<br />
Fetscherstr. 74<br />
01307 Dresden<br />
Ch. 2.15<br />
Dr. med. Andreas Reske<br />
University Hospital Dresden<br />
Clinic & Outpatient Clinic for<br />
Anesthesiology & Intensive Treatment<br />
Fetscherstr. 74<br />
01307 Dresden<br />
Ch. 2.15<br />
Prof. Dr. med. Eckhard Rickels<br />
Celle General Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Neurotraumatology<br />
Siemensplatz 4<br />
29223 Celle<br />
Ch. 1.5, 2.6, 3.5<br />
Prof. Dr. med. Dieter Rixen<br />
Clinic for Trauma Surgery & Orthopedics<br />
BG Trauma Hospital Duisburg<br />
Grossenbaumer Allee 250<br />
47249 Duisburg<br />
Ch. 3.1, 3.10<br />
Prof. Dr. med. Steffen Ruchholtz<br />
University Hospital Giessen/Marburg<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Baldingerstrasse<br />
35043 Marburg<br />
Ch. 2.2<br />
Richard A. Santucci<br />
Detroit Receiving Hospital<br />
Wayne State University School of Medicine<br />
Detroit, Michigan (USA)<br />
Ch. 1.8, 2.8, 3.6<br />
PD Dr. med. Stefan Sauerland<br />
Institute for Research in Operative Medicine<br />
(IFOM)<br />
University of Witten, Herdecke<br />
Ostmerheimerstr. 200<br />
51109 Cologne<br />
Ch. 1.4, 1.8, 2.8, 2.15, 3.6, 3.10<br />
Dr. med. Ulrich Schächinger<br />
University Hospital Regensburg<br />
Department of Trauma Surgery<br />
Franz-Josef-Strauss-Allee 11<br />
93053 Regensburg<br />
Ch. 1.4<br />
Prof. Dr. med. Michael Schädel-Höpfner<br />
University Hospital Dusseldorf<br />
Clinic for Trauma & Hand Surgery<br />
Moorenstrasse 5<br />
40225 Düsseldorf<br />
Ch. 2.11, 3.9<br />
Dr. med. Bodo Schiffmann<br />
Muthstrasse 22<br />
74889 Sinsheim<br />
Ch. 2.14, 3.13<br />
Mechthild Schiffmann<br />
St.Maria Hospital Frankfurt<br />
Richard-Wagner-Str. 14<br />
60318 Frankfurt/Main<br />
Ch. 2.14, 3.13<br />
Prof. Dr. med. Thomas Schildhauer<br />
BG Trauma Hospital Bergmannsheil<br />
Surgical University Hospital and Outpatient<br />
Clinic<br />
Bürkle-de-la-Camp-Platz 1<br />
44789 Bochum<br />
Ch. 1.4<br />
- x -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Prof. Dr. med. Dr. med. dent. Rainer<br />
Schmelzeisen<br />
University Hospital Freiburg<br />
Clinic for Oral and Maxillofacial Surgery<br />
Hugstetterstr. 55<br />
79106 Freiburg<br />
Ch. 2.13, 3.12<br />
Dr. med. Dierk Schreiter<br />
University Hospital Dresden<br />
Clinic for Visceral, Thoracic and Vascular<br />
Surgery<br />
Fetscherstr. 74<br />
01307 Dresden<br />
Ch. 1.9, 2.15<br />
PD Dr. med. Karsten Schwerdtfeger<br />
University Hospital of the Sauerland<br />
Clinic for Neurosurgery<br />
Kirrbergerstrasse<br />
66421 Homburg/Saar<br />
Ch. 1.5, 2.6, 3.5<br />
Prof. Dr. med. Andreas Seekamp<br />
University Hospital Schleswig-Holstein (Kiel<br />
Campus)<br />
Clinic for Trauma Surgery<br />
Arnold-Heller-Str. 7<br />
24105 Kiel<br />
Ch. 1.4, 2.7<br />
PD. Dr. med. Julia Seifert<br />
Trauma Hospital Berlin<br />
Clinic for Trauma Surgery & Orthopedics<br />
Warener Str. 7<br />
12683 Berlin<br />
Ch. 3.3, 3.4<br />
Dr. med. Daniel Seitz<br />
University Hospital Ulm<br />
Clinic for Trauma, Hand, Plastic &<br />
Reconstructive Surgery<br />
Steinhövelstr. 9<br />
89070 Ulm<br />
Ch. 3.2<br />
Efraim Serafetinides<br />
417 NIMTS<br />
Athens (Greece)<br />
Ch. 1.8, 2.8, 3.6<br />
Prof. Dr. med. Hartmut Siebert<br />
Diakonie Hospital Schwäbisch-Hall<br />
Department of Surgery II<br />
Diakoniestr. 10<br />
74523 Schwäbisch-Hall<br />
Ch. 2.11, 3.9<br />
PD Dr. med. Christian Simanski<br />
Cologne City Hospitals gGmbH<br />
Merheim Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Sports Injuries<br />
51058 Cologne<br />
Ch. 3.10<br />
PD Dr. med. Dirk St<strong>eng</strong>el<br />
Trauma Hospital Berlin<br />
Center for Clinical Research<br />
Warener Str. 7<br />
12683 Berlin<br />
Ch. 3.3, 3.4<br />
Dr. med. Erwin Stolpe<br />
Gartenseeweg 8<br />
82402 Seeshaupt<br />
Ch. 1.4<br />
Prof. Dr. med. Johannes Sturm<br />
Schlüterstr. 32<br />
48149 Münster<br />
Ch. 1.4<br />
Prof. Dr. med. Klaus Michael Stürmer<br />
University Hospital Göttingen – Georg-<br />
August University<br />
Department of Trauma Surgery, Plastic and<br />
Reconstructive Surgery<br />
Robert-Koch Str. 40<br />
37075 Göttingen<br />
Ch. 2.2<br />
Prof. Dr. med. Lothar Swoboda<br />
German Society of Thoracic Surgery<br />
Eisendorfer Pferdeweg 17a<br />
21075 Hamburg<br />
Ch. 3.2<br />
PD Dr. med. Georg Täger<br />
University Hospital Essen<br />
Clinic for Trauma Surgery<br />
Hufelandstr. 55<br />
45147 Essen<br />
Ch. 2.10<br />
- xi -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Dr. med. Thorsten Tjardes<br />
Cologne City Hospitals gGmbH<br />
Merheim Hospital<br />
Clinic for Trauma Surgery, Orthopedics &<br />
Sports Injuries<br />
51058 Cologne<br />
Ch. 3.10<br />
Levent Türkeri<br />
Marmara University School of Medicine<br />
Department of Urology<br />
34688 Haydarpaşa – Istanbul (Turkey)<br />
Ch. 1.8, 2.8, 3.6<br />
Prof. Dr. med. Gregor Voggenreiter<br />
Kösching Clinic<br />
Orthopedic Traumatological Center, Hospital<br />
im Naturpark Altmühltal<br />
Ostenstr. 31<br />
85072 Eichstätt<br />
Ch. 2.4<br />
Prof. Dr. med. Thomas J. Vogl<br />
University Hospital Frankfurt<br />
Institute of Diagnostic & Interventional<br />
Radiology<br />
Theodor-Stern-Kai 7<br />
60590 Frankfurt/Main<br />
Ch. 2.17<br />
PD Dr. med. Felix Walcher<br />
University Hospital Frankfurt<br />
Clinic for Trauma, Hand & Reconstructive<br />
Surgery<br />
Theodor-Stern-Kai 7<br />
60590 Frankfurt<br />
Ch. 1.4<br />
Dr. med. Frank Waldfahrer<br />
University Hospital Erlangen<br />
Oto-Rhino-Laryngology Clinic, Head &<br />
Neck Surgery<br />
Waldstrasse 1<br />
91054 Erlangen<br />
Ch. 2.14, 3.13<br />
Prof. Dr. med. Christian Waydhas<br />
University Hospital Essen<br />
Clinic for Trauma Surgery<br />
Hufelandstr. 55<br />
45147 Essen<br />
Ch. 1.1, 1.2, 1.4<br />
Dr. med. Michael Weinlich<br />
Medconteam GmbH<br />
Gerhard-Kindler-Str. 6<br />
72770 Reutlingen<br />
Ch. 1.4<br />
Dr. med. Christoph Georg Wölfl<br />
BG Trauma Hospital Ludwigshafen<br />
Clinic for Trauma Surgery & Orthopedics<br />
Ludwig-Guttmann-Str. 13<br />
67071 Ludwigshafen<br />
Ch. 1.4<br />
Prof. Dr. med. Alexander Woltmann<br />
BG Trauma Hospital Murnau<br />
Department of Trauma Surgery<br />
Prof. Küntscher-Str. 8<br />
82418 Murnau am Staffelsee<br />
Ch. 2.9, 3.7<br />
Dr. med. Nedim Yücel<br />
Practice for Orthopedics & Trauma Surgery<br />
Dülmener Str. 60<br />
48653 Coesfeld<br />
Ch. 3.10<br />
Prof. Dr. med. Gerald Zimmermann<br />
Theresienkrankenhaus Mannheim<br />
Trauma Surgery<br />
Bassermannstr. 1<br />
68165 Mannheim<br />
Ch. 1.4<br />
Prof. Dr. med. Hans Zwipp<br />
University Hospital Dresden<br />
Clinic & Outpatient Clinic for Trauma &<br />
Reconstructive Surgery<br />
Fetscherstr. 74<br />
01307 Dresden<br />
Ch. 1.9, 2.12, 3.11<br />
- xii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Contents<br />
Contents...................................................................................................................................xii<br />
List of tables........................................................................................................................... xiv<br />
List of figures .......................................................................................................................... xv<br />
List of abbreviations.............................................................................................................. xvi<br />
A Rationale und goals .......................................................................................................... 1<br />
A.1 Publisher/experts/medical associations/authors............................................ 4<br />
A.2 Target user group............................................................................................. 6<br />
B Methods............................................................................................................................. 7<br />
B.1 Literature search and selection of evidence................................................... 7<br />
B.2 Formulating the recommendation and finding consensus............................ 9<br />
B.3 Distribution and implementation.................................................................. 10<br />
B.4 Quality indicators and evaluation................................................................. 10<br />
B.5 Validity and updating of guideline ............................................................... 11<br />
B.6 Funding of the guideline and disclosure of potential conflicts of interests11<br />
1 Prehospital ...................................................................................................................... 14<br />
1.1 Introduction .................................................................................................... 14<br />
1.2 Airway management, ventilation and emergency anesthesia..................... 17<br />
1.3 Volume replacement ...................................................................................... 40<br />
1.4 Thorax ............................................................................................................. 51<br />
1.5 Traumatic brain injury.................................................................................. 86<br />
1.6 Spine ................................................................................................................ 93<br />
1.7 Extremities .................................................................................................... 104<br />
1.8 Genitourinary tract ...................................................................................... 114<br />
1.9 Transport and designated hospital ............................................................. 116<br />
1.10 Mass casualty incident (MCI) ..................................................................... 122<br />
2 Emergency room .......................................................................................................... 131<br />
2.1 Introduction .................................................................................................. 131<br />
2.2 The emergency room - personnel and equipment resources.................... 135<br />
2.3 Criteria for emergency room activation..................................................... 144<br />
2.4 Thorax ........................................................................................................... 152<br />
2.5 Abdomen ....................................................................................................... 176<br />
2.6 Traumatic brain injury................................................................................ 189<br />
2.7 Pelvis.............................................................................................................. 197<br />
2.8 Genitourinary tract ...................................................................................... 211<br />
Page<br />
- xii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.9 Spine .............................................................................................................. 226<br />
2.10 Extremities .................................................................................................... 240<br />
2.11 Hand .............................................................................................................. 248<br />
2.12 Foot ................................................................................................................ 251<br />
2.13 Mandible and midface ................................................................................. 253<br />
2.14 Neck ............................................................................................................... 256<br />
2.15 Resuscitation................................................................................................. 260<br />
2.16 Coagulation system ...................................................................................... 269<br />
2.17 Interventional control of bleeding .............................................................. 291<br />
3 Emergency surgery phase............................................................................................ 297<br />
3.1 Introduction .................................................................................................. 297<br />
3.2 Thorax ........................................................................................................... 300<br />
3.3 Diaphragm .................................................................................................... 309<br />
3.4 Abdomen ....................................................................................................... 311<br />
3.5 Traumatic brain injury................................................................................ 336<br />
3.6 Genitourinary tract ...................................................................................... 341<br />
3.7 Spine .............................................................................................................. 354<br />
3.8 Upper extremity............................................................................................ 363<br />
3.9 Hand .............................................................................................................. 368<br />
3.10 Lower extremity ........................................................................................... 382<br />
3.11 Foot ................................................................................................................ 402<br />
3.12 Mandible and midface ................................................................................. 412<br />
3.13 Neck ............................................................................................................... 418<br />
- xiii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
List of tables<br />
Table 1: AWMF table of levels for guideline development [4]......................................................1<br />
Table 2: CEBM evidence classification [9] ....................................................................................8<br />
Table 3: Prehospital volume replacement - mortality ...................................................................41<br />
Table 4: Diagnostic valency of a pathologic auscultation finding with regard to a<br />
hemo/pneumothorax ................................................................................................54<br />
Table 5: Diagnostic valency of dyspnea and tachypnea with regard to hemo/pneumothorax......54<br />
Table 6: Diagnostic valency of thoracic pain with regard to hemo/pneumothorax ......................55<br />
Table 7: Statistical probabilities for the presence of a clinically relevant hemopneumothorax in<br />
various combinations of findings after blunt chest injury (basic assumption: 10%<br />
prevalence as pretest probability and independence of test) ...................................55<br />
Table 8: Incidence of pneumothorax in the presence of chest injury............................................56<br />
Table 9: Complication rates for pleural drains inserted in the prehospital versus in-hospital phase<br />
.................................................................................................................................64<br />
Table 10: Complications when inserting a pleural drain...............................................................83<br />
Table 11: Composition and presence of specialist grade physicians in the enlarged emergency<br />
room team in relation to the care level ..................................................................141<br />
Table 12: Glasgow Outcome Scale (GOS) [8]:...........................................................................260<br />
Table 13: Drug options for coagulation therapy .........................................................................285<br />
Table 14: Midline laparotomy versus transverse upper abdominal laparotomy in abdominal<br />
trauma ....................................................................................................................312<br />
Table 15: Damage Control versus definitive management .........................................................314<br />
Table 16: Methods for abdominal wall closure...........................................................................316<br />
Table 17: Second look after packing...........................................................................................318<br />
Table 18: Angioembolization......................................................................................................321<br />
Table 19: Angiography................................................................................................................322<br />
Table 20: Interventions after blunt splenic injuries.....................................................................323<br />
Table 21: Interventions after blunt or penetrating splenic injuries .............................................326<br />
Table 22: Primary anastomosis versus ileostomy after penetrating colon injury .......................329<br />
Table 23: Hand suture versus stapler after penetrating colon injury...........................................330<br />
Table 24: Hand suture versus stapler after penetrating colon injury...........................................331<br />
Table 25: Grading classification of renal trauma according to the American Association for the<br />
Surgery of Trauma (AAST) [117].........................................................................342<br />
- xiv -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
List of figures<br />
Figure 1: Operational algorithm for mass casualty incident (MCI) [7] ......................................125<br />
Figure 2: Triage of injured persons at mass casualty incident [7] ..............................................127<br />
Figure 3: Treatment algorithm for complex pelvic trauma [49] .................................................206<br />
Figure 4: CPR algorithm according to the ERC Guidelines [36]................................................264<br />
Figure 5: Algorithm on the diagnostic and therapeutic procedure for suspected renal injuries..347<br />
- xv -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
List of abbreviations<br />
A. Artery<br />
a. p. Anteroposterior<br />
AAST American Association for the Surgery of Trauma<br />
ABC Assessment of blood consumption<br />
ABCD Airway/Breathing/Circulation/Disability<br />
ACS Abdominal compartment syndrome<br />
ACS COT American College of Surgeons Committee on Trauma<br />
ACTH Adrenocorticotropic hormone<br />
AIS Abbreviated Injury Scale<br />
AJ Ankle joint<br />
ALI Acute lung injury<br />
ALS Advanced Life Support<br />
APC Apheresis platelet concentrate<br />
aPTT Activated partial thromboplastin time<br />
ArbStättV Workplace Regulation<br />
ARDS Acute respiratory distress syndrome<br />
ASIA-IMSOP American Spinal Injury Association – International Medical Society<br />
of Paraplegia<br />
ASR Workplace Directive<br />
ASS Acetyl salicylic acid<br />
AT Antithrombin<br />
ATLS ® Advanced Trauma Life Support<br />
AUC Area under the curve<br />
AWMF Association of Scientific Medical Societies in Germany<br />
ÄZQ Medical Center for Quality in Medicine<br />
BÄK German Medical Association<br />
BE Base excess, base deviation<br />
BG Berufsgenossenschaftliches [Statutory Accident Insurance Company]<br />
BGA Blood gas analysis<br />
BLS Basic Life Support<br />
BP Blood pressure<br />
BS Body surface<br />
BW Body weight<br />
C 1-7 Cervical spine<br />
CA Contrast agent<br />
- xvi -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Ca ++ Calcium<br />
CCT Cranial computed tomography/tomogram<br />
CEBM Oxford Centre for Evidence Based Medicine<br />
CI Confidence interval<br />
CK-MB Creatine kinase MB<br />
COPD Chronic obstructive pulmonary disease<br />
CPAP Continuous positive airway pressure<br />
CPP Cerebral perfusion pressure<br />
CPR Cardiopulmonary resuscitation<br />
CRASH Clinical Randomization of Antifibrinolytics in Significant<br />
Hemorrhage<br />
CS Cervical spine<br />
CST Cosyntropine stimulation test<br />
CT Computed tomography/tomogram<br />
CTA CT angiography<br />
DC Damage control<br />
DDAVP Desmopressin<br />
DGAI German Society of Anesthesiology and Intensive Care Medicine<br />
DGNC German Society of Neurosurgery<br />
<strong>DGU</strong> German Trauma Society<br />
DIC Disseminated intravasal coagulopathy<br />
DIVI German Interdisciplinary Association for Intensive and Emergency<br />
Care<br />
DL Definitive laparotomy<br />
DO2I Oxygen delivery index<br />
DPL Diagnostic peritoneal lavage<br />
DSA Digital subtraction angiography<br />
DSTC Definitive surgical trauma care<br />
EAES European Association for Endoscopic Surgery<br />
EAST Eastern Association for the Surgery of Trauma<br />
ECG Electrocardiogram<br />
EL<br />
EMS<br />
Evidence level<br />
Emergency medical systems<br />
EMT Emergency Medical Technician<br />
ENT Otorhinolaryngology therapy<br />
ER Emergency room<br />
ERC European Resuscitation Council<br />
- xvii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
ERG Electroretinogram<br />
ETC European Trauma Course<br />
FÄ/FA Specialist physician<br />
FAST Focused assessment with ultrasonography for trauma<br />
FFP Fresh frozen plasma<br />
FR French (equals 1 Charrière [CH] and thus ⅓ mm)<br />
GCS Glasgow Coma Scale/Score<br />
GoR Grade of Recommendation<br />
GOS Glasgow Outcome Scale<br />
h Hour<br />
Hb Hemoglobin<br />
HES Hydroxy ethyl starch<br />
HFS Hannover fracture scale<br />
ICP Intracranial pressure<br />
ICU Intensive care unit<br />
IFOM Institute for Research in Operative Medicine (IFOM)<br />
INR International Normalized Ratio (subsequent standardization for<br />
Quick value)<br />
INSECT Interrupted or Continuous Slowly Absorbable Sutures – Evaluation<br />
of<br />
Abdominal Closure Techniques<br />
ISS Injury severity score<br />
ICU Intensive care unit<br />
IU International unit<br />
IVP Intravenous pyelography<br />
L 1-5 Lumbar spine<br />
LÄK German regional medical association<br />
LEAP Lower Extremity Assessment Project<br />
LISS Less invasive stabilization system<br />
LoE Level of Evidence<br />
LS Lumbar spine<br />
LSI Limb Salvage Index<br />
MAL Mean axillary line<br />
MCI Mass casualty incident<br />
MCL Medioclavicular line<br />
MESS Mangled Extremity Severity Score<br />
MILS Manual in-line stabilization<br />
- xviii -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
MPH Miles per hour<br />
mrem Millirem (equals 0.01 millisievert)<br />
MRI Magnetic resonance imaging<br />
MRT Medical radiologic technologist<br />
MSCT Multi-slice helical computed tomography<br />
NaCl Sodium chloride<br />
NASCIS National Acute Spinal Cord Injury Study<br />
NASS CDS National Automotive Sampling System Crashworthiness Data<br />
System<br />
NEF Emergency physician vehicle<br />
NISSSA Nerve injury, Ischemia, Soft-tissue injury, Skeletal injury, Shock and<br />
Age of patient<br />
NS<br />
n. s.<br />
Paranasal sinuses<br />
Not significant<br />
OMS Oral and maxillofacial surgery<br />
OP Operation/surgery<br />
OPSI Overwhelming Postsplenectomy Syndrome<br />
OR Odds ratio<br />
pAOD Peripheral arterial occlusive disease<br />
PASG Pneumatic anti-shock garment<br />
PC Platelet concentrate<br />
PCC Prothrombin complex concentrate<br />
PHTLS ® Prehospital Trauma Life Support<br />
PMMA Polymethyl methacrylate<br />
POVATI Postsurgical Pain Outcome of Vertical and Transverse Abdominal<br />
Incision<br />
PPV Positive predictive value<br />
PRBC Packed red blood cells<br />
PSI Predictive Salvage Index<br />
PTFE Polytetrafluorethylene<br />
PTS <strong>Polytrauma</strong> Score<br />
PTT Partial thromboplastin time<br />
QM Quality management<br />
RCT Randomized controlled trial<br />
RISC Revised Injury Severity Classification<br />
ROSC Return of spontaneous circulation<br />
ROTEM Rotational thromboelastometry<br />
- xix -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
RöV German X-ray Ordinance<br />
RR Relative risk<br />
RSI Rapid sequence induction<br />
RTA Road traffic accident<br />
RTH Rescue helicopter<br />
RTS Revised trauma score<br />
RTW Ambulance<br />
RX X-ray<br />
S Spine<br />
SAGES Society of American Gastrointestinal and Endoscopic Surgeons<br />
SBP Systolic blood pressure<br />
SCIWORA Spinal Cord Injury Without Radiographic Abnormality<br />
SIRS Systemic inflammatory response syndrome<br />
START Simple Triage And Rapid Treatment<br />
T 1-12 Thoracic vertebrae<br />
TARN Trauma audit and research network<br />
TASH-Score Trauma Associated Severe Hemorrhage Score<br />
TBI Traumatic brain injury<br />
TEE Transthoracic/transesophageal echocardiography<br />
TEG Thromboelastography<br />
TIC Trauma-induced coagulopathy<br />
tPA Tissue-specific plasminogen activator<br />
Trali Transfusion-associated acute lung failure<br />
TRGS Technical Rules for Hazardous Substances<br />
TRIS Tris(hydroxymethyl)aminomethane<br />
TRIS Trauma Injury Severity Score Method<br />
TS Thoracic spine<br />
TTAC Trauma Team Activation Criteria<br />
i. v. Intravenous<br />
VEP Visually evoked potential<br />
WMD Weighted mean difference<br />
- xx -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
A Rationale und goals<br />
Introduction<br />
Medical guidelines are systematically developed decision aids for service providers and patients<br />
on the appropriate method applicable in specific health problems [1]. Guidelines are important<br />
tools for providing a rational and transparent basis for decisions in medical care [2]. Through<br />
imparting knowledge, they are intended to contribute towards improving care [3].<br />
The process of developing guidelines must be systematic, independent and transparent [2].<br />
Guideline development for Level 3 guidelines follows the criteria according to the AWMF/ÄZQ<br />
[German Medical Center for Quality in Medicine] specifications including all elements of<br />
systematic development [4].<br />
Table 1: AWMF table of levels for guideline development [4].<br />
Level 1 Experts group:<br />
A representatively formed group of experts from the Scientific Medical Society<br />
draws up a guideline in informal consensus, which is approved by the board of<br />
the society.<br />
Level 2 Formal evidence research or formal consensus finding:<br />
Guidelines are developed from formally assessed statements in scientific<br />
literature or discussed and approved in one of the proven formal consensus<br />
processes. Formal consensus processes consist of the nominal group process, the<br />
Delphi method and the consensus conference.<br />
Level 3 Guideline including all elements of systematic development:<br />
Formal consensus finding, systematic literature search and evaluation, and<br />
classification of studies and recommendations according to the criteria of<br />
evidence-based medicine, clinical algorithms, outcome analysis, decision<br />
analysis.<br />
The present guideline is a Level 3 guideline.<br />
Starting position<br />
Accidents are the most common cause of death in children and young adults [5]. In 2007, 8.22<br />
million people were injured in accidents and 18,527 people suffered a fatal accident according to<br />
statistics from the German Federal Institute for Occupational Safety and Health (Bundesanstalt<br />
für Arbeitsschutz und Arbeitsmedizin) [6]. The management of a severely injured person is<br />
typically an interdisciplinary task. It presents a major chall<strong>eng</strong>e to those involved in the<br />
provision of care because of the sudden occurrence of the accident situation, the unpredictability<br />
of the number of injured persons and the heterogeneity of the patient population [7].<br />
An S1 guideline was issued by the German Society of Trauma Surgery in 2002 on the<br />
management of multiply injured patients and those with severe injuries. However, there is no upto-date,<br />
general, comprehensive, evidence-based guideline. This was the rationale for drawing up<br />
- 1 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
an interdisciplinary guideline for the management of multiply injured patients and those with<br />
severe injuries.<br />
Requirements of the guideline<br />
The guideline must meet the following fundamental requirements:<br />
� Guidelines for the treatment of polytrauma and patients with severe injuries are aids in<br />
decision-making in specific situations, based on the current state of scientific knowledge and<br />
on procedures proven in practice.<br />
� Due to its complexity, there is no single ideal concept for the treatment of polytrauma and<br />
patients with severe injuries.<br />
� Guidelines need to be constantly monitored and adapted to the current state of knowledge.<br />
� Using the recommendations in this guideline, it should be possible to treat the vast majority<br />
of severely injured/multiply injured patients.<br />
� Routine monitoring of treatment and monitoring the effect of treatment are necessary.<br />
� Regular discussion with all involved (physicians, nursing staff, patients, if possible patients’<br />
families) should make the goals and methods of treatment of polytrauma and patients with<br />
severe injuries transparent.<br />
Aims of the guideline<br />
This interdisciplinary <strong>S3</strong> guideline is an evidence-based and consensus-based tool with the aim<br />
of improving the management of multiply injured patients and those with severe injuries. The<br />
recommendations are intended to contribute towards the optimization of structural and process<br />
quality in hospitals and in prehospital management and, through their implementation, help to<br />
improve outcome quality in terms of case fatality rate or quality of life.<br />
The guideline, which is based on the current state of scientific knowledge and on procedures<br />
proven in practice, is intended to provide a decision-making aid in specific situations. The<br />
guideline can be used not only in the acute treatment situation and in the debriefing but also in<br />
discussions about local protocols by the quality circles in individual hospitals. Legal (and<br />
insurance) aspects and those relevant to billing are not explicitly dealt with in this guideline. The<br />
regulations of the German Social Code Book (Sozialgesetzbuch) (SBG VII) apply.<br />
The guideline should be an interdisciplinary decision-making aid. For this reason, it is also<br />
suitable for drawing up new treatment protocols in individual hospitals and for revising protocols<br />
already in existence.<br />
The aim of the guideline is to support the care of the vast majority of severely injured persons.<br />
Individual patients with defined pre-existing concomitant diseases or specific injury patterns may<br />
not all be adequately covered due to their specific problems.<br />
- 2 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The guideline is intended to stimulate further discussion to optimize the care of severely injured<br />
persons. Constructive criticism is therefore expressly welcomed. Ideally, any amendments<br />
should be briefly summarized, backed up by references and forwarded to the publisher.<br />
Apart from the terms of reference of this guideline, it is intended to draw up interdisciplinary<br />
recommendations on the ongoing process management of severely injured persons during the<br />
acute and post-acute phase.<br />
- 3 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
A.1 Publisher/experts/medical societies/authors<br />
The responsibility for this guideline lies with the German Trauma Society (Deutsche<br />
Gesellschaft für Unfallchirurgie e. V.).<br />
The following medical societies were involved in drawing up the guideline:<br />
German Society of General and Visceral Surgery (Deutsche Gesellschaft für Allgemein- und<br />
Viszeralchirurgie e. V.)<br />
German Society of Anesthesiology and Intensive Care Medicine (Deutsche Gesellschaft für<br />
Anästhesiologie und Intensivmedizin e. V )<br />
German Society of Endovascular and Vascular Surgery (Deutsche Gesellschaft für<br />
Gefäßchirurgie und Gefäßmedizin e.V.)<br />
German Society of Hand Surgery (Deutsche Gesellschaft für Handchirurgie e.V.)<br />
German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (Deutsche Gesellschaft für<br />
HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V.)<br />
German Society of Oral and Maxillofacial Surgery (Deutsche Gesellschaft für Mund-, Kiefer-<br />
und Gesichtschirurgie e.V.)<br />
German Society of Neurosurgery (Deutsche Gesellschaft für Neurochirurgie e.V.)<br />
German Society of Thoracic Surgery (Deutsche Gesellschaft für Thoraxchirurgie e.V.)<br />
German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie e.V.)<br />
German Society of Urology (Deutsche Gesellschaft für Urologie e.V.)<br />
German Radiology Society (Deutsche Röntg<strong>eng</strong>esellschaft e.V.)<br />
Moderation, coordination and project management<br />
The German Trauma Society as the lead medical association has devolved central coordination<br />
for this guideline to the Institute for Research in Operative Medicine (Institut für Forschung in<br />
der Operativen Medizin) (IFOM). The tasks were:<br />
� coordination of the project group<br />
� methods support and quality assurance<br />
� systematic literature search<br />
� procurement of literature<br />
� data administration<br />
� structural and editorial harmonization of the guideline texts<br />
- 4 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
� coordination of necessary discussions, meetings, and consensus conferences<br />
� administration of financial resources<br />
- 5 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Main treatment phase responsibilities<br />
The guideline was divided into 3 main treatment phases: prehospital, emergency room, and<br />
emergency surgery. Coordinators were assigned responsibility for each of these treatment<br />
phases. The tasks were:<br />
� establishing the contents of the guideline<br />
� screening and evaluating the literature on the different treatment strategies for multiply<br />
injured patients and those with severe injuries, drawing up and coordinating the guideline<br />
texts<br />
The AWMF, represented by Professor I. Kopp, provided methods guidance in drawing up the<br />
guideline.<br />
A.2 Target user group<br />
The guideline’s target user group is primarily the physicians and all other medical professionals<br />
involved in the management of a multiply injured patient or one with severe injuries. The<br />
recommendations relate to adult patients. Recommendations on the care of children and<br />
adolescents are only given occasionally in the guideline.<br />
- 6 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
B Methods<br />
The guideline project was first announced in December 2004 and again in May 2009.<br />
The guideline on the “Treatment of multiply injured patients and those with severe injuries” was<br />
developed according to a binding process with a structured plan. It is the result of a systematic<br />
literature search and critical evaluation of the evidence from available data using scientific<br />
methods as well as discussion with experts in a formal consensus procedure.<br />
B.1 Literature search and selection of evidence<br />
The key questions for the systematic literature search and evaluation were formulated on the<br />
basis of preliminary work during 2005. The literature searches were carried out in the MEDLINE<br />
database (via PubMed) using medical keywords (Medical Subject Headings/MeSH), partly<br />
supplemented by a free text search. The filter recommended in PubMed was used to identify<br />
systematic reviews. Supplementary searches were conducted in the Cochrane Library<br />
(CENTRAL) (in this case with keywords and text words in the title and abstract). The<br />
publication period selected was 1995-2010, and German and English as the publication<br />
languages.<br />
The literature searches were carried out partly by the Institute for Research in Operative<br />
Medicine (IFOM) and partly by the authors themselves. The results of the literature searches,<br />
sorted according to topic, were forwarded to the individual authors responsible for each topic.<br />
The underlying key questions, the literature searches carried out with date and number of hits<br />
and, if applicable, search limitations were documented and can be found in the appendix to the<br />
separate Methods Report.<br />
Selection and evaluation of the relevant literature<br />
The authors of each chapter selected and evaluated the literature included in the guideline. This<br />
was carried out according to the criteria of evidence-based medicine. Sufficient randomization,<br />
allocation concealment, blinding and the statistical analysis were taken into account.<br />
The evidence statement for the recommendations was based on the evidence classification of the<br />
Oxford Center of Evidence-Based Medicine (CEBM), March 2009 version. In formulating the<br />
recommendations, priority was given to studies with the highest level of evidence available<br />
(LoE).<br />
- 7 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 2: CEBM evidence classification [9]<br />
Level Studies on therapy/prevention/etiology<br />
1a<br />
1b<br />
1c<br />
2a<br />
2b<br />
2c<br />
3a<br />
3b<br />
Systematic review of randomized controlled trials (RCT)<br />
An RCT (with narrow confidence interval)<br />
All or none principle<br />
Systematic review of well-planned cohort studies<br />
A well-planned cohort study or a low-quality RCT<br />
Outcome studies, ecological studies<br />
Systematic review of case-control studies<br />
Individual case-control study<br />
4. Case-series or low-quality cohort/case-control studies<br />
5. Expert opinion without explicit critical appraisal of the evidence or based on<br />
physiology/bench research<br />
Three grades of recommendation (GoR) were possible (A, B, O). The wording of the key<br />
recommendation employs “must” “should” or “can” as appropriate. In determining the GoR, in<br />
addition to the underlying evidence, benefit-risk evaluations were also taken into account, as<br />
were the directness and homogeneity of the evidence along with clinical expertise [2].<br />
- 8 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
B.2 Formulating the recommendation and finding consensus<br />
The medical societies involved each nominated at least one delegate who, as a representative of<br />
that subject discipline, participated in drawing up the guideline. Each medical society had a vote<br />
in the consensus process.<br />
The recommendations and the grades of recommendation were approved in 5 consensus<br />
conferences (April 18-19, 2009, June 30, 2009, September 8, 2009, November 26-27, 2009 and<br />
February 01, 2010):<br />
The course of action at these conferences, assisted by the TED (electronic voting) system, was in<br />
6 steps:<br />
� the opportunity to review the guideline manuscript before the conference and to compile<br />
notes on the proposed recommendations and grades;<br />
� presentation and explanation from each author responsible on the pre-formulated proposals<br />
for recommendations;<br />
� registration via moderators of participants’ opinions and alternative proposals on all<br />
recommendations, with speaker contributions solely for clarification;<br />
� voting on all recommendations and grades of recommendation and on the cited alternatives;<br />
� discussion of the points on which no “strong consensus” could be reached in the first round;<br />
� <strong>final</strong> voting.<br />
Most of the recommendations were approved with “strong consensus” (agreement of > 95% of<br />
participants). Areas in which no strong consensus could be reached are marked in the guideline<br />
and the various positions are expounded. In classifying the consensus str<strong>eng</strong>th, the following<br />
consensus grades were decided on in advance [9]:<br />
� strong consensus: > 95% of participants agreed<br />
� consensus: > 75-95% of participants agreed<br />
� majority consensus: > 50–75% of participants agreed<br />
� no consensus: < 50% of participants agreed<br />
The records of the meetings can be viewed at the Institute for Research in Operative Medicine<br />
(IFOM). The Delphi method was then applied to recommendations for which no consensus could<br />
be reached in the consensus conferences. A detailed methods report is available for viewing on<br />
the AWMF website and has been filed at the Institute for Research in Operative Medicine<br />
(IFOM).<br />
- 9 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
B.3 Distribution and implementation<br />
The guideline is to be distributed in the following ways:<br />
� via the internet: AWMF website (http://www.awmf-online.de) and the websites of the<br />
medical societies and professional organizations involved in the guideline<br />
� via printed media:<br />
− Publication of the guideline as a manual/book by the <strong>DGU</strong>. A copy will be made<br />
available to all hospitals involved in the <strong>DGU</strong> Trauma Network. In addition, all<br />
hospitals involved will be notified in writing about where and how the guideline<br />
can be viewed on the AWMF homepage.<br />
− Publication of extracts of the guideline and of implementation strategies in<br />
journals of the medical societies involved.<br />
− To simplify use of the guideline, a summary of the guideline containing the key<br />
recommendations is also to be published in the Deutsches Ärzteblatt [German<br />
medical journal].<br />
� via conferences, workshops, professional training courses offered by the medical societies<br />
involved.<br />
Various complementary measures are to be implemented in this guideline. In addition to the<br />
presentation of the recommendations at conferences, a link to topic-specific professional training<br />
courses is planned.<br />
In addition, implementation at all the German hospitals involved in the trauma network is to be<br />
evaluated approximately one year after publication of the guideline. In particular, it should be<br />
recorded how the guideline has been used and what practical suggestions the participants have<br />
gained from their experience to pass on to other users.<br />
B.4 Quality indicators and evaluation<br />
The audit filters were developed as criteria for quality management for the <strong>DGU</strong> Trauma<br />
Registry. Based on the available audit filters, the following criteria were established for this<br />
guideline:<br />
Process quality for evaluation in the prehospital phase:<br />
� duration of prehospital time between accident and hospital admission for severely injured<br />
patients with ISS ≥ 16 [∅min ± SD]<br />
� intubation rate in patients with severe chest injury (AIS 4-5) by the emergency physician<br />
[%, n/total]<br />
� intubation rate in patients with suspected traumatic brain injury (unconscious, Glasgow<br />
Coma Scale [GCS] ≤ 8) [%, n/total]<br />
- 10 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Process quality for evaluation of emergency room management:<br />
� time between hospital admission and performance of a chest X-ray in severely injured<br />
patients (ISS ≥ 16) [∅ min ± SD]<br />
� time between hospital admission and performance of an ultrasound scan of the<br />
abdomen/chest in cases of severe trauma (ISS ≥ 16) [∅ min ± SD]<br />
� time until performance of a computed tomography (CT) scan of the cranium (CCT) in prehospital<br />
unconscious patients (GCS ≤ 8) [∅ min ± SD]<br />
� time until performance of a full-body CT scan on all patients, if carried out [∅ min ± SD]<br />
� time from emergency admission arrival to completion of diagnostic study in severely injured<br />
persons if this has been completed normally (ISS ≥ 16) [∅ min ± SD]<br />
� time from emergency admission arrival to completion of diagnostic study in severely injured<br />
persons if this has been interrupted due to emergency (ISS ≥ 16) [∅ min ± SD]<br />
Outcome quality for overall evaluation:<br />
� standardized mortality rate: observed mortality divided by the expected prognosis based on<br />
RISC (Revised Injury Severity Classification) in severely injured persons (ISS ≥ 16)<br />
� standardized mortality rate: observed mortality divided by the expected prognosis based on<br />
TRISS (Trauma Injury Severity Score Method) in severely injured persons (ISS ≥ 16)<br />
The routine recording and evaluation of these data offer a vital opportunity to monitor<br />
improvements in quality in the management of multiply injured patients and those with severe<br />
injuries. It is not possible to ascertain from this which effects are due to the guideline. Quality<br />
indicators should continue to be developed based on the aforementioned criteria.<br />
B.5 Validity and updating of guideline<br />
This guideline is valid until December 2014. The German Trauma Society is responsible for<br />
introducing an updating process. The cooperation of the German Society of Plastic,<br />
Reconstructive and Esthetic Surgeons (Deutsche Gesellschaft der Plastischen, Rekonstruktiven<br />
und Ästhetischen Chirurgen) and of the German Society of Burns Medicine (Deutsche<br />
Gesellschaft für Verbrennungsmedizin) and the thematic inclusion of burns, large skin/soft tissue<br />
defects and nerve defect injuries (including plexus injuries) is additionally planned for this<br />
updating.<br />
B.6 Funding of the guideline and disclosure of potential conflicts of interests<br />
Reimbursement monies for the methods support, costs for literature acquisition, costs for<br />
organizing the consensus conferences, and costs of materials were provided by the German<br />
Trauma Society and the Institute for Research in Operative Medicine (IFOM) of the University<br />
of Witten/Herdecke. The participants’ travel costs arising from the consensus process were<br />
- 11 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
covered by those medical societies/organizations sending representatives or by the participants<br />
themselves.<br />
All participants in the consensus conference disclosed potential conflicts of interest in writing. A<br />
summary of declarations of potential conflicts of interest from all coordinators, medical society<br />
delegates, draft authors, and organizers can be found in the appendix to the separate Methods<br />
Report of this guideline. Furthermore, the forms used to disclose potential conflicts of interest<br />
can be requested from the Institute for Research in Operative Medicine (IFOM).<br />
Grateful thanks are extended to the coordinators of the individual subsections, the authors and<br />
participants in the consensus process for their wholly voluntary work.<br />
- 12 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Field, M.J. and K.N. Lohr, eds. Clinical Practice<br />
Guidelines: Directions for a New Program. 1990,<br />
National Academy Press: Washington, D.C.<br />
2. Council of Europe, Developing a Methodology for<br />
drawing up Guidelines on Best Medical Practices:<br />
Recommendation Rec(2001)13 adopted by the<br />
Committee of Ministers of the Council of Europe on<br />
10 October 2001 and explanatory memorandum.<br />
2001, Strasbourg Cedex: Council of Europe.<br />
3. Kopp, I.B., [Perspectives in guideline development<br />
and implementation in Germany.]. Z Rheumatol,<br />
2010.<br />
4. Arbeitsgemeinschaft der Wissenschaftlichen<br />
Medizinischen Fachgesellschaften. 3-Stufen-Prozess<br />
der Leitlinien-Entwicklung: eine Klassifizierung.<br />
2009; Available from: http://www.uniduesseldorf.de/AWMF/ll/ll_s1-s3.htm.<br />
5. Robert Koch-Institut, ed.; Gesundheit in Deutschland.<br />
Gesundheitsberichterstattung des Bundes. 2006,<br />
Robert Koch-Institut: Berlin.<br />
6. Bundesanstalt für Arbeitsschutz und Arbeitsmedizin.<br />
Unfallstatistik: Unfalltote und Unfallverletzte 2007 in<br />
Deutschland. 2007; Available from:<br />
www.baua.de/cae/servlet/content<br />
blob/672542/publicationFile/49620/Unfallstatistik-<br />
2007.pdf;jsessionid=CC8B45BA699EE9E4E11AC1E<br />
AD359CB34.<br />
7. Bouillon, B., et al., Weißbuch Schwerverletzten-<br />
Versorgung. Empfehlungen zur Struktur, Organisation<br />
und Ausstattung stationärer Einrichtungen zur<br />
Schwerverletzten-Versorgung in der Bundesrepu-blik<br />
Deutschland., ed. D.G.f.U.e.V. (<strong>DGU</strong>). 2006, Berlin:<br />
Dt. Gesellschaft für Unfallchirurgie e.V.<br />
8. Oxford Centre of Evidence-based Medicine (CEBM):<br />
Levels of Evidence (March 2009); Available from:<br />
www.cebm.net/index.aspx?o=1025.<br />
9. Schmiegel, W., et al.: <strong>S3</strong>-Leitlinie “Kolorektales<br />
Karzinom: Available from:<br />
www.krebsgesellschaft.de/download/s3_ll_kolorektal<br />
es_karzinom_2008.pdf.<br />
- 13 -
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1 Prehospital<br />
1.1 Introduction<br />
Within the structured emergency services, the professional treatment of severely injured patients<br />
starts right at the accident scene. The subsequent course can be set at this stage. So, even for this<br />
initial treatment phase, it is expedient and necessary to develop the clearest priorities and<br />
strategies for dealing with the situation. Due to the difficult environmental conditions in the<br />
prehospital emergency situation, the evidence level is low yet the full diversity of experience and<br />
expert knowledge is considerable. Moreover, the benefit-risk evaluation is disputed in a number<br />
of interventions, not least in considering the point at which an essentially indicated intervention<br />
should be carried out, for example, in the prehospital phase or only once admitted to hospital.<br />
Finally, the polarization between “stay and treat” and “load and go” also plays a role here. In<br />
addition, a large amount of scientific knowledge has been gained from different emergency<br />
systems and its transferability to specific situations in Germany is often ambiguous.<br />
Those active on the spot want a highly specific recommendation with broad validity but this<br />
desire is in conflict with the unfortunately often weak data available and the resulting unreliable<br />
conclusions. This desire can only be met by achieving a consensus among the experts, on the<br />
understanding that scientific uncertainty continues to exist in such areas and that there are<br />
differences between different emergency systems and cultures.<br />
The structuring of the prehospital guideline section is based on several considerations. Basically,<br />
the management of a (potentially) severely injured patient involves a sequence of actions that<br />
follow certain priorities. Every detail and individual step of the sequence itself cannot be<br />
evidence-based with proof of general validity. Moreover, many individual circumstances relating<br />
to the actual patient have to be considered so that not all possible sequence models can be<br />
depicted. The contents of the guideline were therefore not oriented to a specific sequence<br />
algorithm but focused instead on individual aspects. These sections concentrate on anatomic<br />
regions (head, chest, abdomen, spine, extremities, and pelvis). In the prehospital phase, very few<br />
invasive interventional options are available; of these the most important (volume replacement,<br />
airway management, chest drain) are dealt with in terms of indications and implementation.<br />
The individual aspects, interventions, and guidelines must be embedded in a general pathway of<br />
action that sets priorities and prescribes action pathways and sequences. A framework of this<br />
kind can be provided by programs such as Prehospital Trauma Life Support (PHTLS), Advanced<br />
Trauma Life Support (ATLS), European Trauma Course (ETC), and others. As such programs<br />
already exist and the individual steps cannot be individually scientifically proven, as indicated<br />
above, the attempt was not made to develop such a program in this guideline package. The<br />
individual guidelines are not intended to replace these programs but to represent the aspects<br />
embedded in them.<br />
Besides directly treating the individual patient, general aspects also play a role in the prehospital<br />
phase. On the one hand, a decision must be made about the designated hospital. It must be able<br />
to treat all acute, life-threatening injuries immediately and independently. The initial-treating<br />
hospital must have clear, well-ordered transfer strategies for injuries which require a special<br />
structure or expertise. In addition to the increasing number of trauma networks being set up, the<br />
Prehospital - Introduction 14
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
recommendations in the White Paper of the German Trauma Society [1] may be of great benefit<br />
here [2]. The resulting local and regional regulations can provide the emergency physician with<br />
additional support when selecting a suitable designated hospital. Besides the hospital structure,<br />
however, organizational and logistical circumstances, weather and road conditions or the time of<br />
day can also be significant in addition to purely medical considerations. Inextricably linked to<br />
this is the question of whether the patient is in fact severely injured. Criteria for this purpose are<br />
defined which are aligned to actual detected or suspected injuries, impairment of vital functions<br />
or mechanisms of injury. Finally, a balance must be found between the desire to underestimate as<br />
few patients as possible and the consequence of classifying too many patients unnecessarily as<br />
severely injured (overtriage). Conversely, although undertriage reduces the number of<br />
unnecessary emergency room alerts, it is at the cost of having underestimated more genuinely<br />
severely injured patients. The latter is viewed by many as the more critical model. Every trauma<br />
center should come to an agreement about this within its network or with the emergency services<br />
in its area.<br />
The mass casualty incident represents a rare yet particularly chall<strong>eng</strong>ing situation. Until the<br />
arrival of the on-duty lead emergency physician, the emergency physician who arrives on the<br />
scene first must take over this function. The switch from individual medical care to triage<br />
represents a special chall<strong>eng</strong>e and the algorithm should provide support here.<br />
Many important, central domains are dealt with in the present edition of the prehospital<br />
polytrauma guideline. But some major topics, for example, pain therapy or prehospital<br />
management of traumatic brain injury, are not included. These are to be drawn up in future<br />
stages of guideline development, as well as other topics that are requested by the users.<br />
Overall, the rapid, smoothly running medical care of (severely) injured patients is the focus of all<br />
action. In this context, the emergency services must work hand-in-hand with the hospitals. To<br />
this end, the 2008 Key Points Paper [3] on emergency medical management of patients in<br />
hospital and prehospital demands that definitive clinical treatment shall be achieved within 90<br />
minutes for major emergency medical clinical pictures such as a severely injured patient. To<br />
make this possible, a time of 60 minutes from emergency call to hospital admission must be<br />
achieved. The scope of emergency physician care must be aimed at these targets.<br />
Prehospital - Introduction 15
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Bouillon, B., V. Bühren, et al. (2006). Weißbuch<br />
Schwerverletzten-Versorgung. Empfehlungen zur<br />
Struk-tur,Organization und Ausstattung stationärer<br />
Einrichtungen zur Schwerverletzten-Versorgung in<br />
der Bundesrepublik Deutschland. German Society for<br />
Trauma Surgery e.V.<br />
2. Eckpunktepapier zur notfallmedizinischen<br />
Versorgung der Bevölkerung in Klinik und Präklinik<br />
(2008) Arbeitsgemeinschaft Südwestdeutscher<br />
Notärzte (agswn), Institut für Notfallmedizin und<br />
Medizinmanagement (INM), Bundesärztekammer<br />
(BÄK), Bundesvereinigung der<br />
Arbeitsgemeinschaften der Notärzte Deutschlands<br />
(BAND), Deutsche Gesellschaft für Anästhesiologie<br />
und Intensivmedizin (DGAI), Deutsche Gesellschaft<br />
für Chirurgie (DGCH), Deutsche Gesellschaft für<br />
Kardiologie (DGK), Deutsche Gesellschaft für<br />
Neurochirurgie (DGNC), Deutsche Gesellschaft für<br />
Unfallchirurgie (<strong>DGU</strong>), Deutsche Gesellschaft für<br />
Neonatologie und Pädiatrische Intensivmedizin<br />
(GNPI), Arbeiter Samariter Bund (ASB),<br />
Unternehmerverband privater Rettungsdienste (BKS),<br />
Deutsches Rotes Kreuz (DRK), Johanniter-Unfall-<br />
Hilfe (JUH), Malteser Hilfsdienst (MHD), Ständige<br />
Konferenz für den Rettungsdienst (SKRD). Notfall<br />
und Rettungsmedizin 11:421-422<br />
Prehospital - Introduction 16
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.2 Airway management, ventilation and emergency anesthesia<br />
Summary<br />
Endotracheal intubation and ventilation, and hence definitive securing of the airways, with the<br />
aim of the best possible oxygenation and ventilation of the patient, is a central therapeutic<br />
measure in emergency medicine [80]. The basic vital functions directly linked to survival have to<br />
be secured. The “A” for airway and “B” for breathing are First Aid measures found in<br />
established standards on trauma care and therefore have a particular value in terms of weighting<br />
in both the prehospital and the early hospital management [3, 74, 107].<br />
Variations in the emergency medical services (EMS) internationally pose a problem. Whereas<br />
paramedics are often used in the Anglo-American region, the emergency physician system is<br />
widely used in continental Europe. But even here there are differences. In Germany, (specialist)<br />
physicians in all disciplines can be involved in the emergency service after acquiring an<br />
appropriate additional qualification but in Scandinavian countries this is mainly the prerogative<br />
of anesthesiologists [9]. Consequently, the evaluation of international studies on the topic of<br />
securing the airway in the prehospital phase reveals that emergency services personnel have<br />
different levels of training. Depending on the personnel employed and how commonly they<br />
perform intubation, a high rate of esophageal intubations is found in up to 12% of cases in the<br />
literature [20]. In addition, there is a high rate of failed intubations (up to 15%) [99]. In<br />
paramedic systems, non-guideline-compliant airway management is more common [39]. Due to<br />
the different clinical routine of the users, negative outcomes in particular cannot be transferred<br />
directly from paramedic systems to the German emergency services and emergency physician<br />
system [60, 89]. In the Federal Republic of Germany, the agreed minimum qualification of<br />
“Additional qualification in emergency medicine” and the introduction of emergency anesthesia<br />
in the emergency physician system offers a different scenario compared to the Anglo-American<br />
paramedic system.<br />
The following features of the prehospital setting can and must influence the establishing of<br />
indications and planning of anesthesia, intubation and ventilation:<br />
� level of experience and routine training of emergency physician<br />
� circumstances of the medical emergency (e.g., patient is trapped, rescue time)<br />
� type of transport (land-based versus air support)<br />
� transport time<br />
� concomitant injuries around the airway and anything (assessable) that impedes intubation<br />
Depending on the individual case, the indication to carry out or not to carry out prehospital<br />
anesthesia, intubation/airway management and ventilation ranges between the extremes of<br />
“advanced training level, long transport time, simple airway” and “little experience, short<br />
transport time, predicted difficult airway management”. In any event, sufficient oxygenation<br />
must be secured by appropriate measures.<br />
Prehospital – Airway management, ventilation and emergency anesthesia 17
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
If no methodologically high-quality studies were available, a recommendation would still be<br />
issued by a consensus of experts if clinically relevant. The following recommendations cover<br />
emergency anesthesia, airway management and ventilation in the prehospital phase and<br />
emergency room management.<br />
Key recommendations<br />
Emergency anesthesia, endotracheal intubation, and ventilation must be<br />
carried out in the prehospital phase in multiply injured patients with apnea<br />
or gasping ( 29<br />
breaths per minute)<br />
GoR A<br />
GoR B<br />
The multiply injured patient must be preoxygenated before anesthesia. GoR A<br />
The in-hospital endotracheal intubation, emergency anesthesia and<br />
ventilation must be carried out by trained, experienced anesthesiologists.<br />
Explanation:<br />
GoR A<br />
Severe multiple injuries have a serious effect on the integrity of the human body in its entirety.<br />
In addition to the acute trauma consequences for the individual body sections, it causes a<br />
mediator-mediated whole-body reaction, i.e. Systemic Inflammatory Response Syndrome (SIRS)<br />
[26, 54]. Tissue oxygenation takes on special significance in this damage cascade. Tissue<br />
oxygenation can only be achieved if uptake, transport and release of oxygen are guaranteed.<br />
Oxygen uptake is only possible if the airway is secured, and endotracheal intubation is the gold<br />
standard according to the current European and non-European guidelines [32, 73, 74]. A severe<br />
impairment of consciousness due to a traumatic brain injury with a Glasgow Coma Score (GCS)<br />
< 9 is regarded as an intubation indication [8]. Endotracheal intubation for the consciousnessimpaired<br />
trauma patient with a GCS ≤ 8 is also recommended both prehospital and in-hospital<br />
according to the guideline of the Eastern Association for the Surgery of Trauma (EAST) [32] and<br />
other training programs (e.g., ATLS ® [3]). Hypoxia and hypotension are the “lethal duo” which<br />
induces secondary damage particularly in polytrauma with traumatic brain injury [18, 19, 52, 87,<br />
90]. It must be further pointed out that even patients with a GCS of 13 or 14, who were intubated<br />
Prehospital – Airway management, ventilation and emergency anesthesia 18
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
endotracheally in the prehospital phase, displayed abnormal cerebral computed tomography<br />
(38%) and intracranial bleeding (28%) [36]. In a prehospital cohort study, it was shown that<br />
endotracheal intubation has a positive effect on survival following severe traumatic brain injury<br />
[56]. Another retrospective study showed a reduced case fatality rate for children with severe<br />
traumatic brain injury who were intubated by emergency physicians in the prehospital phase as<br />
compared to those receiving care on Basic Life Support (BLS) and delayed intubation in regional<br />
trauma centers [91]. If consideration is limited to a pediatric patient population, the prehospital<br />
endotracheal intubation in this study was carried out by emergency medical personnel with good<br />
transferability to the German emergency physician system. Using the Trauma and Injury<br />
Severity Score (TRISS) method, another study also confirms that prehospital endotracheal<br />
intubation leads to improved outcomes in survival and neurologic function [38]. Another paper<br />
further showed an improvement in measured systolic blood pressure, oxygen saturation and endtidal<br />
carbon dioxide (etCO2 compared to the baseline values prior to prehospital intubation in<br />
patients with severe traumatic brain injury [11].<br />
Current review papers, however, refer to heterogeneous patient collectives, differing emergency<br />
services systems and differently trained users and therefore do not always come to a positive<br />
conclusion about intubation [9, 12, 25, 31, 60, 62, 69, 74, 98, 100]. The EAST guideline group<br />
also tackled this problem. In the “Guidelines for Emergency Intubation immediately following<br />
traumatic injury”, it was claimed that there are no randomized controlled trials on this research<br />
question. On the other hand, however, the authors of the EAST Guideline also found no studies<br />
that could present an alternative treatment strategy proven to be effective. In summary,<br />
endotracheal intubation was assessed overall as such an established procedure in hypoxia/apnea<br />
that, despite a lack of scientific evidence, a Grade A recommendation was formulated [73]. Other<br />
indications for endotracheal intubation (e.g., chest injury) are controversial issues in the literature<br />
[78]. There was evidence that hypoxia and respiratory insufficiency were a consequence of<br />
severe chest injury (multiple rib fractures, pulmonary contusion, unstable chest wall).<br />
Endotracheal intubation is recommended if the hypoxia cannot be remedied by oxygenation, by<br />
the exclusion of tension pneumothorax, and by basic airway management procedures [32].<br />
Prehospital endotracheal intubation in patients with severe chest injury is suitable for preventing<br />
hypoxia and hypoventilation, which are associated with secondary neurologic damage and<br />
extremely severe consequences for the rest of the body. However, with difficult, prolonged<br />
intubation attempts and the associated hypoventilation and danger of hypoxia, endotracheal<br />
intubation itself can cause procedure-related secondary harms or even death. A database analysis<br />
of the Trauma Registry of the German Trauma Society showed no advantage in prehospital<br />
endotracheal intubation in patients with chest injury without respiratory insufficiency [78].<br />
However, severe chest injury with respiratory insufficiency does present an indication for<br />
prehospital endotracheal intubation whereby the decision to intubate should be dependent on the<br />
respiratory insufficiency and not on the (suspected) diagnosis of severe chest injury, which is<br />
associated with a certain degree of uncertainty [7].<br />
Endotracheal intubation is included as an “Advanced Life Support” procedure in the prehospital<br />
action algorithms of various training programs (e.g., PHTLS ® [71]. Using a scoring system to<br />
evaluate management problems plus the relevant autopsy reports, a series of fatal traffic<br />
accidents were retrospectively analyzed to characterize the effectiveness of prehospital care and<br />
potentially avoidable fatal incidents [76]. This flagged up an extended “prehospital and early in-<br />
Prehospital – Airway management, ventilation and emergency anesthesia 19
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
hospital care period” and a “lack of airway securing using intubation” as factors which led to the<br />
incidence of avoidable fatal incidents [76].<br />
A retrospective cohort study of 570 intubated patients compared to 8,137 non-intubated patients<br />
showed that the prehospital intubated patients had a prehospital phase which was between 5.2-<br />
10.7 minutes longer than the non-intubated patients [24]. The effect of early intubation within 2<br />
hours following trauma on the incidence of subsequent organ failure was evaluated in a<br />
prospective non-randomized study [97]. Despite a significantly higher degree of injury, there<br />
was a lowered incidence of organ failure and lower case fatality rate in the group of patients who<br />
were endotracheally intubated “early” within 2 hours following trauma, compared to the “later”<br />
intubated patients. The following factors must therefore be taken into account in selecting the<br />
best time to introduce anesthesia and endotracheal intubation: injury pattern, personal experience<br />
of the emergency physician/anesthesiologist, environmental conditions, transport distance,<br />
available equipment and complications associated with the procedure. Taking these points into<br />
consideration, the definitive care that the multiply injured patient should receive is emergency<br />
anesthesia with endotracheal intubation and ventilation. With the appropriate indication and<br />
appropriate training level, endotracheal intubation should be performed prehospital but, at the<br />
latest, during emergency room management. According to the analysis of data from the Trauma<br />
Registry of the German Trauma Society, out of 24,771 patients, 31% were unconscious at the<br />
accident scene (GCS < 9), 19% had severe hemodynamic instability (systolic blood pressure<br />
< 90 mmHg) and, overall, 55% of patients were endotracheally intubated by the emergency<br />
physician during the prehospital phase [77]. According to this analysis, in the case of 9% of<br />
multiply injured patients, it was necessary to discontinue the emergency room phase in hospital<br />
in favor of an emergency intervention/surgery; a total of 77% of multiply injured patients<br />
received surgery and 87% needed intensive care [77]. Due to a traumatic brain injury and/or<br />
chest injury, many multiply injured patients required intensive care ventilation and invasive<br />
ventilation therapy and all required adequate pain relief. In the study mentioned, the mean<br />
ventilation period for multiply injured patients was 9 days [77].<br />
In order to prevent the harmful effects of hypoxia and hypoventilation, emergency anesthesia<br />
and endotracheal intubation and ventilation should be introduced prehospital or, at the latest,<br />
during emergency room care for the appropriate indication and with the appropriate training<br />
level. A large retrospective study using a trauma registry from a Level I trauma center studied<br />
6,088 patients who received endotracheal intubation within the first hour following hospital<br />
admission [88]. In addition, according to this trauma registry, a further 26,000 trauma patients<br />
were endotracheally intubated after the first hour of hospital care on the day of admission. In the<br />
hands of experienced anesthesiologists, the “rapid sequence induction” proved in these cases to<br />
be an effective, safe procedure in hospital care: no patient died as a result of endotracheal<br />
intubation. Of 6,088 patients, 6,008 were successfully intubated orotracheally (98.7%) and a<br />
further 59 nasotracheally (0.97%). Only 17 patients (0.28%) had to have a cricothyroidotomy<br />
and 4 patients (0.07%) received an emergency tracheotomy. Following the endotracheal<br />
intubation, 3 more patients received an emergency tracheotomy during the course [88]. In<br />
another retrospective study of a monocenter trauma registry, 1,000 trauma patients (9.9% out of<br />
10,137 patients) who had been endotracheally intubated within 2 hours of admission to the<br />
Trauma Center were studied [85]. At < 1%, the incidence of surgically securing the airway was<br />
uncommon in this study as well. Aspiration occurred in 1.1% of cases of endotracheal intubation.<br />
Prehospital – Airway management, ventilation and emergency anesthesia 20
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Early intubation was seen as safe and effective by the authors [85]. These data also confirm that<br />
endotracheal intubation of trauma patients is a safe procedure in the hands of trained personnel.<br />
Another retrospective study from a paramedic-supported system with 175 endotracheally<br />
intubated patients showed a success rate of 96.6% with a markedly higher cricothyroidotomy<br />
rate of 2.3% [37]. In 1.1% of cases, the patient was ventilated by bag-valve-mask during transfer<br />
to hospital. There were 5 instances found of right mainstem dislocation (2.9%) and 2 cases of<br />
tube dislocation (1.1%). No case of failed intubation was documented.<br />
In a retrospective study of a trauma registry, 3,571 prehospital endotracheal intubations in<br />
trauma patients were compared with 746 in the emergency room phase [6]. The endotracheal<br />
intubation first carried out during emergency admission was associated with a higher risk of a<br />
fatal course compared both to non-intubated patients (odds ratio [OR] 3.1; 95% confidence<br />
interval [-CI]; 2.1–4.5, p < 0.0001) and to patients who had already been endotracheally<br />
intubated in the prehospital phase (OR 3.0; 95% CI: 1.9–4.9, p < 0.0001) [6]. In addition, it was<br />
shown that patients who had been endotracheally intubated in the prehospital phase did not have<br />
a higher risk of dying than non-intubated patients in the emergency room phase (OR: 1.1; 95%<br />
CI: 0.7–1.9; p = 0.6). The authors concluded that the patients who were endotracheally intubated<br />
during emergency admission should have already been intubated in the prehospital phase [6].<br />
In a prehospital cohort study with comparable injury severity (ISS 23 versus 24) and similar<br />
duration of care (27 versus 29 min, p = n.s.), 60 patients were treated by emergency services<br />
personnel (emergency medical technician [EMT], intubation rate 3%) and 64 patients in<br />
Advanced Life Support mode by emergency physicians (intubation rate 100%). Oxygen<br />
saturation was significantly improved upon arrival in hospital (SaO2: 86 versus 96; p = 0.04) and<br />
systolic blood pressure was significantly higher (105 versus 132 mmHg, p = 0.03). There was no<br />
difference in all-cause case fatality rate (42% versus 40%, p = 0.76). However, a sub-group<br />
analysis showed a significant survival advantage for those patients with a GCS between 6 and 8<br />
who had been treated by an emergency physician (case fatality rate: 78 versus 24%, p < 0.01; OR<br />
3.85, 95% CI: 1.84–6.38, p < 0.001). The authors concluded that the case fatality rate is reduced<br />
by a prehospital emergency physician system offering rapid sequence induction, sufficient<br />
oxygenation and circulation drug therapy particularly for patients with clouded consciousness<br />
[56].<br />
In the German-speaking emergency physician system, pediatric and adult emergency patients<br />
can be endotracheally intubated with a very high success rate if this procedure is carried out by<br />
experienced and trained personnel. In a prospective study over a period of 8 years, 4% of all<br />
pediatric emergency patients (82 out of 2,040 children) were endotracheally intubated [35].<br />
Pediatric emergency callouts made up 5.6% of all emergency calls (2,040 out of 36,677<br />
emergency physician callouts). Anesthesiologists carried out 58 of the pediatric endotracheal<br />
intubations with a success rate of 98.3%. Based on the incidence, the known number of<br />
emergency physicians employed each year, and their absolute number of callouts, it was<br />
calculated that each emergency physician in the emergency physician service has a gap of, on<br />
average, 3 years between pediatric endotracheal intubations and 13 years between infant<br />
endotracheal intubations. These results show that endotracheal intubation in childhood is rare<br />
outside the hospital setting and special attention must therefore be paid to maintaining specialist<br />
Prehospital – Airway management, ventilation and emergency anesthesia 21
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
expertise and appropriate training outside the emergency services and emergency physician<br />
service.<br />
A prospective study of a cohort of 16,559 patients managed in the prehospital phase included<br />
2,850 trauma patients of which 259 (9.1%) were endotracheally intubated. More than 2 attempts<br />
were required in 3.9% of cases before endotracheal intubation was successful, and there was a<br />
failed intubation in 3.9% of cases. A difficult airway was described in 18.2% of cases. In<br />
comparison, patients with cardiac arrest had a difficult airway in only 16.7% of cases. This study<br />
also showed a success rate of 98.0% by anesthesia-trained emergency physicians [94]. Another<br />
prospective study of an emergency physician system showed a success rate of 98.5% in 598<br />
patients (of which 10% were trauma patients ) [92]. In another prospective study, endotracheal<br />
intubation by anesthesia-trained emergency physicians achieved a 100% success rate in a<br />
collective of 342 patients [n = 235 (68.7%) trauma patients]. In this case, endotracheal intubation<br />
was successful at the first attempt in 87.4% of cases, at the second attempt in 11.1% and at the<br />
third attempt in 1.5% [48]. Another study of the German emergency physician system showed a<br />
success rate of 97.9% in prehospital endotracheal intubation of trauma patients [1].<br />
In a retrospective cohort study with 194 patients with traumatic brain injury, there was a<br />
significant difference in the case fatality rate between patients treated with basic life support<br />
(BLS) procedures in the land-based emergency services and patients who were treated with<br />
advanced life support (ALS) procedures by anesthesiologists in the air-borne emergency services<br />
(25 versus 21 %, p < 0.05). In this study, the survival rate of patients with traumatic brain injury<br />
who were treated highly significantly with more invasive measures in the air rescue group<br />
(intubation 92 versus 36%, chest drain 5 versus 0%) was better than the survival rate of patients<br />
treated in the land-based emergency services (54 versus 44%, p < 0.05) [10].<br />
Procedural-related complications<br />
Regarding procedural-related complications, a retrospective study using data from a trauma<br />
registry showed that there was no higher risk of pneumonia developing in 271 prehospital and<br />
357 in-hospital endotracheally intubated trauma patients [96]. Regarding epidemiological data,<br />
prehospital intubated patients showed a lower GCS (4 versus 8, p < 0.001) and a higher injury<br />
severity according to the ISS (25 versus 22, p < 0.007) but otherwise no differences in the patient<br />
characteristics. Nevertheless, although it was to be expected, there was no difference in the<br />
l<strong>eng</strong>th of hospital stay for both patient collectives (15.7 versus 15.8 d), in the l<strong>eng</strong>th of intensive<br />
care stay (7.6 versus 7.3 d), in the number of days on a ventilator (7.8 versus 7.2 d), in the case<br />
fatality rate (31.7 versus 28.2%), and in the rate of resistant bacteria (46% in each case). On<br />
average, it took 3 days until the onset of pneumonia in both groups and the pneumonia rate was<br />
also not significantly different in both groups [96]. However, a significantly increased rate of<br />
pneumonia following prehospital intubation compared to in-hospital intubation was observed in<br />
another study [86]. However, this had no influence on the 30-day case fatality rate and the<br />
number of days in intensive care. Moreover, the group of prehospital intubated patients had an<br />
increased injury severity. In another study, frequency of pulmonary complications was found to<br />
be related to injury severity but not to intubation mishaps [84]. It cannot be definitely proven that<br />
prehospital endotracheal intubation is related to the incidence of pulmonary complications. In a<br />
retrospective study of 244 patients endotracheally intubated in the prehospital phase by an<br />
Prehospital – Airway management, ventilation and emergency anesthesia 22
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
emergency physician, desaturation with an SpO2 < 90% was documented in 18% of cases and<br />
hypotension with systolic blood pressure < 90 mmHg in 13% of cases. The two complications<br />
did not occur in parallel in any of the cases [72]. Overall, a low complication rate can be<br />
accordingly assumed.<br />
Preoxygenation<br />
To avoid a fall in oxygen saturation during the introduction of anesthesia and endotracheal<br />
intubation, the multiply injured patient should, if practicable, be preoxygenated for up to 4<br />
minutes with an oxygen concentration of 100% via a face mask with reservoir [74]. In a nonrandomized<br />
controlled study of 34 intensive-care patients, the mean paO2 was (T0) 62<br />
± 15 mmHg at the start of preoxygenation, (T4) 84 ± 52 mmHg after 4 minutes, (T6) 88<br />
± 49 mmHg after 6 minutes and (T8) 93 ± 55 mmHg after 8 minutes. The differences in paO2<br />
were significantly different between T0 and T4–8 , but no statistical differences could be obtained<br />
between the paO2 between T4, T6 and T8. 24% of patients even showed a reduction in the paO2<br />
between T4 and T8. A longer period of preoxygenation for 4 to 8 minutes did not lead to any<br />
further marked improvement in arterial oxygen partial pressure and delayed securing the airway<br />
in critical patients [67, 68]. Accordingly, sufficient preoxygenation for 4 minutes has special<br />
importance in securing the airway in multiply injured patients.<br />
Training<br />
Key recommendation:<br />
Emergency medical personnel must be regularly trained in emergency<br />
anesthesia, endotracheal intubation, and alternative ways of securing an<br />
airway (bag-valve-mask, supraglottic airway devices, emergency<br />
cricothyroidotomy).<br />
Explanation:<br />
GoR A<br />
In a survey recently carried out among prehospital trained emergency physicians, they were<br />
questioned on their knowledge of and experience in endotracheal intubation and the alternative<br />
methods for securing an airway [93]. This survey included the responses from 340<br />
anesthesiologists (56.1%) and 266 non-anesthesiologists. It revealed that all anesthesia-trained<br />
emergency physicians could demonstrate more than 100 endotracheal intubations performed in<br />
hospital in contrast to only 35% of non-anesthesiologists performing more than 100 in-hospital<br />
intubations. A similar picture emerges for alternative methods for securing an airway as well.<br />
97.8% of anesthesia-trained emergency physicians had used alternative methods for securing an<br />
airway on more than 20 occasions while only 11.1% of non-anesthesia-trained emergency<br />
physicians had equivalent experience (p < 0.05). In addition, it emerges that only 27% of<br />
emergency equipment was equipped with CO2 monitors. From this study it can be concluded<br />
that there is an urgent training need for non-anesthesia-trained emergency physicians in<br />
endotracheal intubation, capnography and alternative methods for securing an airway [74].<br />
Studies on first-year anesthesiology residents showed that more than 60 intubations were<br />
Prehospital – Airway management, ventilation and emergency anesthesia 23
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
necessary in order to achieve a success rate of 90% within the first two endotracheal intubation<br />
attempts under standardized, optimum conditions in surgery [57]. However, as the success of<br />
alternative methods for securing an airway (e.g., supraglottic airways: laryngeal mask, laryngeal<br />
tube) can only be as good as the corresponding training level in this procedure and current<br />
evidence indicates that a corresponding training level is not available everywhere [93],<br />
endotracheal intubation continues to be the gold standard. This knowledge also illustrates that<br />
emergency medical personnel should be regularly trained in endotracheal intubation and<br />
alternative ways of securing an airway [74].<br />
Prehospital – Airway management, ventilation and emergency anesthesia 24
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Alternative methods for securing an airway<br />
Key recommendations<br />
A difficult airway must be anticipated when endotracheally intubating a<br />
trauma patient.<br />
Alternative methods for securing an airway must be provided when<br />
anesthetizing and endotracheally intubating a multiply injured patient.<br />
Fiberoptic intubation must be available as an alternative when anesthetizing<br />
and endotracheally intubating in-hospital.<br />
If difficult anesthetization and/or endotracheal intubation are expected, an<br />
anesthesiologist must carry out or supervise this procedure in-hospital<br />
provided this does not cause a delay in an emergency life-saving measure.<br />
Suitable measures must be in place to ensure that an anesthesiologist is<br />
normally on site in time<br />
After more than 3 intubation attempts, alternative methods must be<br />
considered for ventilation and securing an airway.<br />
Explanation:<br />
GoR A<br />
GoR A<br />
GoR A<br />
GoR A<br />
GoR A<br />
Due to the framework conditions, the endotracheal intubation of an emergency patient is<br />
markedly more difficult in the prehospital environment than in-hospital. A difficult airway must<br />
therefore always be anticipated when endotracheally intubating a trauma patient [74]. In a large<br />
study of 6,088 trauma patients, risk factors and difficulties in endotracheal intubation consisted<br />
of foreign bodies in the pharynx or larynx, direct injuries to the head or neck with loss of normal<br />
anatomy in the upper airway, airway edema, pharyngeal tumors, laryngospasms and a difficult<br />
pre-existing anatomy[88]. In another study, trauma patients presented difficult airway securing<br />
markedly more frequently (18.2%) than, for example, patients with cardiac arrest (16.7%) and<br />
patients with other diseases (9.8%). Reasons described for difficult airway management were the<br />
position of the patient (48.8% of cases), difficult laryngoscopy (42.7% of cases), secretion or<br />
aspiration in the oropharynx (15.9% of cases) and traumatic injuries (including bleeding/burns)<br />
in 13.4% of cases [94]. Technical problems occurred in 4.3% and other causes in 7.3% of cases.<br />
Further studies show a similar frequency of causes of difficult intubation (blood 19.9%, vomit<br />
15.8%, hypersalivation 13.8%, anatomy 11.7%, changes in anatomy caused by trauma 4.4%,<br />
position of patient 9.4%, lighting conditions 9.1%, technical problems 2.9% [48]. In a<br />
prospective study with 598 patients, adverse events and complications occurred significantly<br />
more frequently in patients with severe injuries than non-traumatized patients (p = 0.001) [92].<br />
At least one event was documented in 31.1% of traumatized patients. The number of attempts<br />
required for intubation was also significantly increased in traumatized patients (p = 0.007) [92].<br />
Prehospital – Airway management, ventilation and emergency anesthesia 25
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
An increased risk of difficult intubation exists particularly in patients with severe maxillofacial<br />
trauma (OR 1.9, 95% CI: 1.0–3.9, p = 0.05) [22]. Maxillofacial trauma even represents an<br />
independent factor for difficult airway management (OR 2.1, 95% CI: 1.1–4.4, p = 0.038). A<br />
retrospective analysis of a trauma registry over a period of 7 years identified 90 patients with<br />
severe maxillofacial injuries. Of these, 93% initially received definitive airway securing, in 80%<br />
of cases by means of endotracheal intubation and in 15% of cases through surgical airway<br />
securing [21]. On the basis of these available data, the trauma patient must definitely be assumed<br />
to be non-fasting. In addition, blood, vomit or other fluids associated with a more difficult<br />
intubation situation must be expected in the oropharynx to a greater extent. A high-performance<br />
suction unit must therefore be available as a matter of course. For structure- and process-related<br />
reasons, the possibility of a back-up procedure with an experienced anesthesiologist often does<br />
not exist in the prehospital setting but in-hospital the gold standard is generally to involve an<br />
anesthesiologist in the management when difficult intubations and anesthesia are expected. In a<br />
prospective cohort study, it was therefore shown that if an attending physician in anesthesiology<br />
was present at in-hospital emergency intubations, significantly fewer complications occurred<br />
(6.1 versus 21.7%, p < 0.0001) [81]. However, there was no difference in the ventilation-free<br />
days and the 30-day case fatality rate.<br />
If endotracheal airway securing fails, an appropriate algorithm must be followed, reverting back<br />
to bag-valve-mask ventilation and/or alternative methods of securing an airway [4, 15, 49, 73,<br />
74]. In a prospective study, intubation success was evaluated in 598 patients in an emergency<br />
physician system solely staffed by anesthesiologists. Endotracheal intubation was successful at<br />
the first attempt in 85.4% of all patients. Only 2.7% required more than two attempts, and 1.5%<br />
(n = 9) had supralaryngeal aids such as the Combitube (n = 7), laryngeal mask (n = 1) or an<br />
emergency cricothyroidotomy (n = 1) after the third unsuccessful intubation attempt [92]. The<br />
study illustrates that alternative methods must be provided even in highly professional systems<br />
[55].<br />
In a retrospective study of 2,833 patients endotracheally intubated in-hospital at a Level I trauma<br />
center, it was shown that the risk of airway-associated complications was markedly increased<br />
with more than 2 intubation attempts: hypoxemia 11.8 versus 70%, regurgitation 1.9 versus 22%,<br />
aspiration 0.8 versus 13%, bradycardia 1.6 versus 21%, cardiac arrest 0.7 versus 11% [65].<br />
Another study, which was prospective and multi-center, examined over an 18-month period how<br />
many intubation attempts (inserting the laryngoscope into the oral cavity) were necessary for<br />
successful endotracheal intubation in emergency patients [101]. In 94% of cases, endotracheal<br />
intubation was carried out by paramedics and in a further 6% by nurses or emergency physicians.<br />
Overall, 1,941 endotracheal intubations were carried out, of which 1,272 (65.5%) were in<br />
patients with cardiac arrest, 463 (23.9%) as intubation without drug administration in patients<br />
without cardiac arrest, 126 (6.5%) as intubations under sedation in patients without cardiac<br />
arrest, and 80 (4.1%) by means of rapid sequence induction using a hypnotic agent and a muscle<br />
relaxant. Over 30% of patients required more than one intubation attempt to achieve successful<br />
endotracheal intubation. More than 6 intubation attempts were not reported in any case. The<br />
cumulative success rate during the first, second and third intubation attempt was 70%, 85% and<br />
90% in patients with cardiac arrest. It was thus markedly higher than in the other 3 patient<br />
subgroups with intact circulatory function (intubation without drugs: 58%, 69% and 73%;<br />
intubation under sedation: 44%, 63% and 75%; intubation by means of rapid sequence induction:<br />
Prehospital – Airway management, ventilation and emergency anesthesia 26
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
56%, 81% and 91%). The specific success rates of endotracheal intubation by paramedics, nurses<br />
and emergency physicians were not broken down further. The results of this study [101] show<br />
that the cumulative success rate of endotracheal intubation in a paramedic system is markedly<br />
below that of emergency physician systems staffed solely by anesthesiologists, whose rate is 97-<br />
100% [48, 92, 94]. However, the administration of drugs, as they are used during a rapid<br />
sequence induction (including muscle relaxants), helps to facilitate endotracheal intubation in<br />
patients without cardiac arrest and thus leads to a markedly higher intubation success. Both are<br />
frequently vital for survival in an emergency situation. According to the above-cited study<br />
results, alternative methods should be considered for securing an airway after more than 3<br />
intubation attempts [4, 65]. Although fiberoptic procedures are only available in isolated cases in<br />
the prehospital phase, fiberoptic intubation must be available in-hospital. In all common<br />
guidelines and recommendations on emergency airway securing, (awake) fiberoptic intubation is<br />
considered a possible procedure for securing an airway if there is appropriate experience and<br />
appropriate environmental conditions [33, 46, 49, 59].<br />
In contrast, emergency cricothyroidotomy is simply the last resort in a “cannot ventilate - cannot<br />
intubate” situation to secure ventilation and oxygenation in an emergency. In national and<br />
international recommendations and guidelines, emergency cricothyroidotomy has a firm place in<br />
prehospital and hospital phases and is indicated if alternative methods for securing an airway and<br />
bag-valve-mask ventilation are not successful [9, 46, 49, 70].<br />
Prehospital – Airway management, ventilation and emergency anesthesia 27
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Monitoring emergency anesthesia<br />
Key recommendation:<br />
ECG, blood pressure measurement, pulse oxymetry and capnography must be<br />
used to monitor the patient for anesthesia induction, endotracheal intubation<br />
and emergency anesthesia.<br />
Explanation:<br />
GoR A<br />
The German Society of Anesthesiology and Intensive Care Medicine (DGAI) lays down certain<br />
features for a “standard workplace” in its update to the directives on equipping the<br />
anesthesiology workplace [27]. Special attention must be paid to the often difficult prevailing<br />
circumstances (e.g., physical confines, unfavorable lighting conditions, limited resources) in<br />
prehospital emergency medicine and particularly in the care of trauma patients.<br />
The following items of equipment should be available in the prehospital phase for carrying out<br />
and monitoring emergency anesthetization [74]: electrocardiogram (ECG), non-invasive blood<br />
pressure measurement, pulse oxymetry, capnography/capnometry, defibrillator, emergency<br />
respirator, and suction unit. Appropriate equipment must be provided based on the guideline<br />
“Airway Management” of the German Society of Anesthesiology and Intensive Care Medicine<br />
[15] and the German DIN standards for emergency physician vehicle (NEF) [28], rescue<br />
helicopter (RTH) [29] and ambulance (RTW) [30].<br />
In-hospital, the directives of the DGAI must be followed in the emergency room and in the other<br />
hospital wards [27].<br />
Emergency ventilation and capnography<br />
Key recommendations<br />
During endotracheal intubation in the prehospital and in-hospital phases,<br />
capnometry/capnography must be used for monitoring tube placement and<br />
then for monitoring dislocation and ventilation.<br />
Normoventilation must be carried out in endotracheally intubated and<br />
anesthetized trauma patients.<br />
From emergency room treatment onwards, ventilation must be monitored<br />
and controlled by frequent arterial blood gas analyses.<br />
GoR A<br />
GoR A<br />
GoR A<br />
Prehospital – Airway management, ventilation and emergency anesthesia 28
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Explanation:<br />
In the prehospital and in-hospital phases, capnometry/capnography must always be used during<br />
endotracheal intubation for monitoring the placement of the tube and then to reduce incidence of<br />
dislocation and monitor ventilation. Capnography is an essential component here in monitoring<br />
the intubated and ventilated patient [74]. Normoventilation should be carried out in<br />
endotracheally intubated and anesthetized trauma patients. From emergency room treatment<br />
onwards, ventilation must be monitored and controlled by frequent arterial blood gas analyses.<br />
Capnography for monitoring tube placement and dislocation<br />
The most serious complication in endotracheal intubation is an unrecognized esophageal<br />
intubation, which can lead to the death of the patient. This is why, both prehospital and inhospital,<br />
all methods must be applied to recognize esophageal intubation and remedy it<br />
immediately.<br />
The percentage of esophageal intubations reported in the literature starts at less than 1% [100,<br />
106] spanning 2% [40], 6% [75], and reaching almost 17% [53]. Moreover, a high case fatality<br />
rate was shown as a result of tube misplacement in the hypopharynx (33%) or in the esophagus<br />
(56%) [53]. Esophageal intubation is thus not a rare event and, particularly in recent years,<br />
various studies have examined this catastrophic complication of endotracheal intubation in<br />
Germany as well. In a prospective observational study, helicopter emergency physicians trained<br />
in anesthesiology identified an esophageal tube placement in 6 out of 84 (7.1%) trauma patients,<br />
who had been intubated by land-based emergency physicians before arrival of the helicopter, and<br />
an endobronchial tube placement in 11 (13.1%) [95]. The case fatality rate of esophageally<br />
intubated patients was 80% in this study. In another prospective study with 598 patients in a<br />
German emergency physician system, the rate of esophageal intubations by non-medical<br />
personnel or physicians before arrival of the actual emergency physician system was 3.2% [92].<br />
Another prospective observational study revealed esophageal intubation in 5.1% of 58 patients,<br />
who had been intubated by the land-based emergency service or emergency physician before<br />
arrival of the helicopter emergency physician trained in anesthesiology [43]. In a study focusing<br />
on the admitting emergency room team, esophageal intubation was found in 4 out of 375<br />
prehospital intubated and ventilated patients (1.1%) [41].<br />
In a prospective observational study of 153 patients, evidence showed that none of the patients<br />
who had been monitored by capnography had an unrecognized misplaced intubation, but 14 out<br />
of the 60 patients (23.3%) not monitored by capnography had [83]. Capnography therefore<br />
belongs in the standard equipment of the anesthesiology workplace and has dramatically<br />
increased the safety of anesthesia.<br />
In a prospective observational study with 81 patients (n = 58 severe traumatic brain injury [TBI],<br />
n = 6 maxillofacial trauma, n = 17 multiple injuries), markedly greater sensitivity and specificity<br />
was demonstrated by monitoring tube placement by capnography compared to auscultation only<br />
(sensitivity: 100 versus 94%; specificity: 100 versus 66%, p < 0.01) [44]. These data prove that<br />
capnography must always be used for monitoring tube placement.<br />
Prehospital – Airway management, ventilation and emergency anesthesia 29
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
A survey found that in Baden-Wurttemberg only 66% out of 116 emergency physician sites had<br />
capnography available in 2005 [42]. There is an urgent need here for optimization. In addition, it<br />
is unknown how often available capnography is actually used in prehospital endotracheal<br />
intubation, tube position verification, and emergency ventilation monitoring. The goal must be to<br />
reach a capnography rate of 100% in the prehospital and in-hospital phases. On the basis of the<br />
guideline “Airway Management” of the German Society of Anesthesiology and Intensive Care<br />
Medicine and the German DIN standards for emergency physician vehicles (NEF) [28], rescue<br />
helicopters (RTH) [29] and ambulances (RTW) [30] on the mandatory availability of<br />
capnography, the lack of appropriate equipment basically constitutes organizational negligence<br />
[42].<br />
Capnography for normoventilation<br />
The introduction of emergency anesthetization is not only used to maintain adequate<br />
oxygenation but also effective ventilation and thus the elimination of carbon dioxide (CO2),<br />
which accumulates in the human metabolism. Both an accumulation of CO2 (hypercapnia and<br />
hyperventilation) and hyperventilation with consecutive hypocapnia can cause damage<br />
particularly in patients with traumatic brain injury and must be avoided in the first 24 hours [14,<br />
16]. This results in a vicious circle of elevated intracranial pressure, hypercapnia, hypoxemia,<br />
further cellular swelling/edema and subsequent further increase in intracranial pressure.<br />
In a retrospective analysis of prehospital care data from 100 prehospital intubated and ventilated<br />
patients, it was shown that an etCO2 > 30 mmHg was attained in 65 patients and an etCO2 ≤ 29<br />
mmHg in 35 patients. A lower case fatality rate was noticeably more likely in normoventilated<br />
patients (case fatality rate: 29 versus 46%; OR 0.49, 95% CI: 0.1–1.1, p = 0.10) [17].<br />
In a prospective observational study, only 155 out of 492 patients intubated and ventilated in the<br />
prehospital phase showed a paCO2 between 30 and 35 mmHg in the initial arterial blood gas<br />
analysis (BGA) in the emergency room and were thus (according to the study protocol)<br />
normoventilated [102]. Eighty patients (16.3%) who were hypocapnic (paCO2 < 30 mmHg), 188<br />
patients (38.2%) who were mildly hypercapnic (paCO2 36–45 mmHg) and 69 patients (14.0 %)<br />
who were severely hypercapnic (paCO2 > 45 mmHg) were ventilated. The injury severity of the<br />
severely hypercapnic patients (paCO2 > 45 mmHg) was markedly higher and these patients also<br />
had hypoxia, acidosis or hypotension significantly more frequently compared to the other 3<br />
groups. The case fatality rate of prehospital intubated and ventilated trauma patients both with<br />
and without TBI was specifically lowered by normoventilation (OR: 0.57, 95% CI: 0.33–0.99),<br />
with patients with isolated TBI gaining more markedly from normoventilation (OR: 0.31, 95%<br />
CI: 0.31–0.96). According to the available results, hyperventilation with consecutive hypocapnia<br />
(paCO2 < 30 mmHg) in particular appears to be harmful in severely injured patients. These<br />
results make clear that, from emergency room treatment onwards, ventilation should be<br />
monitored and controlled by frequent arterial blood gas analyses.<br />
In a prospective study of 97 patients, it was shown that patients monitored by capnography had a<br />
significantly higher rate of normoventilations (63.2 versus 20%, p < 0.0001) and significantly<br />
fewer hypoventilations (5.3 versus 37.5%, p < 0.0001) compared to patients who were ventilated<br />
without capnography monitoring but by using the 10-10 rule [47]. Capnography is thus an<br />
Prehospital – Airway management, ventilation and emergency anesthesia 30
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
orientating procedure in emergency ventilation. When capnography is used for controlling<br />
ventilation, it must be taken into account that the correlation between etCO2 and paCO2 is<br />
nevertheless weak (r = 0.277) [104]. As a result of a prospective observational study with 180<br />
patients, 80% of patients with an etCO2 of 35–40 mmHg were indeed hypoventilated (paCO2<br />
> 40 mmHg). In a prospective study of 66 intubated and ventilated trauma patients, those<br />
patients in particular with high injury severity according to the ISS, hypotension, severe chest<br />
injury, and metabolic acidosis revealed a larger difference between etCO2 and paCO2 [61]. Thus,<br />
the arterial CO2 (paCO2) cannot always be directly inferred from the CO2 (etCO2) obtained by<br />
capnography [74]. This is due to the fact that good correlation between etCO2 and paCO2 under<br />
physiologic conditions is negatively affected by pulmonary shunt fractions in pulmonary<br />
contusions, atelectasis, hypotension and metabolic acidosis.<br />
Thus, capnography primarily serves to evaluate tube placement and to monitor on-going<br />
ventilation, with ventilation control a secondary use. This was also briefly demonstrated in a<br />
retrospective cohort study with 547 trauma patients: all trauma patients and especially patients<br />
with severe TBI gained from paCO2-controlled ventilation (OR: 0.33, 95% CI: 0.16–0.75). There<br />
was a significant survival advantage if paCO2 was already between 30 and 39 mmHg on<br />
admission to the emergency room (OR 0.32, 95% CI: 0.14–0.75). In patients whose paCO2 could<br />
only be brought into the target range during their stay in the emergency room, there was only a<br />
non-significant trend towards a lower case fatality rate (OR 0.48, 95% CI: 0.21–1.09). A<br />
markedly worse survival rate was shown by those trauma patients who initially had a paCO2 of<br />
30–39 mmHg but were then hypoventilated (paCO2> 39 mmHg) or hyperventilated<br />
(paCO2 < 30 mmHg) or who never attained the target goal of a paCO2 of 30–39 mmHg during<br />
their stay in the emergency room. This study also illustrates that paCO2 must not be freely<br />
inferred from etCO2 [102].<br />
Using capnography to check tube placement and to detect tube dislocations is advisable and<br />
essential. Capnography is the gold standard in standard anesthesia, and ventilation management<br />
is markedly better with capnography than without this procedure. There are limitations to<br />
ventilation management using capnography due to unpredictable shunt fractions. For this reason,<br />
ventilation must be managed by blood gas analysis as early as possible, in other words<br />
immediately upon admission to the emergency room.<br />
Lung protective ventilation<br />
In a prospective randomized study, ventilation with a small tidal volume (6 ml/kg BW) in<br />
patients with acute respiratory distress syndrome (ARDS) led to a significantly reduced case<br />
fatality rate and a lower incidence of barotrauma and improved oxygenation compared to<br />
ventilation with high tidal volume [2]. The multi-center randomized, controlled trial conducted<br />
by the ARDS network confirmed these results in a ventilation with low tidal volume and limiting<br />
plateau pressure to ≤ 30 cm H2O in patients with ARDS [5]. Chest injuries are observed in<br />
around 60% of multiply injured patients with the corresponding consequences (e.g., pulmonary<br />
contusions, ARDS), and the development of an acute lung injury (ALI) as an independent factor<br />
is associated with the case fatality rate (case fatality rate of trauma patients with ALI [n = 93]:<br />
23.7 versus without ALI [n = 190]: 8.4%, p < 0.01) [82]. Thus, lung protective ventilation with a<br />
Prehospital – Airway management, ventilation and emergency anesthesia 31
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
tidal volume of 6 ml/kg BW and with the lowest possible peak pressures must be implemented as<br />
early as possible following endotracheal intubation [45].<br />
Emergency anesthesia<br />
Key recommendations<br />
For endotracheal intubation in multiply injured patients, emergency<br />
anesthesia must be carried out as rapid sequence induction due to the usual<br />
lack of a fasting state and risk of aspiration.<br />
Etomidate should be avoided as an induction agent due to the associated side<br />
effects on adrenal function (ketamine is usually a good alternative here).<br />
Explanation:<br />
GoR A<br />
GoR B<br />
Emergency anesthesia is frequently an unavoidable component of the proper care of a multiply<br />
injured patient. Anesthesia induction must be carried out in a structured way; if carried out<br />
improperly, it is associated with an increased risk of morbidity and case fatality rate [74]. In a<br />
retrospective study, compared to non-emergency intubation (n = 2,136), emergency intubation (n<br />
= 241) was linked to a markedly higher risk of severe hypoxemia (SpO2 < 70%: 25 versus 4.4%,<br />
p < 0.001), regurgitation (25 versus 2.4%, p < 0.001), aspiration (12.8 versus 0.8%), bradycardia<br />
(21.3 versus 1.5%, p < 0.001), arrhythmia (23.4 versus 4.1%, p < 0.001) and cardiac arrest (10.2<br />
versus 0.7%, p < 0.001) [66].<br />
In trauma patients, an airway is secured and anesthesia induction is normally carried out as rapid<br />
sequence induction (RSI) (ileus or crash induction) to secure an airway in the shortest possible<br />
time without aspiration if possible. In a prospective study, an evaluation was conducted over an<br />
18-month period on how many intubation attempts (inserting the laryngoscope into the oral<br />
cavity) were necessary for successful endotracheal intubation in 1,941 emergency patients. The<br />
cumulative intubation success in patients with intact circulatory function differed greatly in the<br />
first 3 intubation attempts between patients who received intubation entirely without drugs (58%,<br />
69% and 73%), intubation only under sedation (44%, 63% and 75%) or intubation by means of<br />
rapid sequence induction (56%, 81% and 91%) [101]. There was a high rate of failed intubations<br />
in other studies as well where no muscle relaxants were administered to optimize the intubation<br />
conditions during anesthesia induction for endotracheal intubation [34]. Drug-supported<br />
anesthesia induction in terms of rapid sequence induction is therefore vital for the success of<br />
endotracheal intubation.<br />
Depending on the hemodynamic state of the patient, the injury pattern, and the personal<br />
experience of the physician, various induction hypnotic agents can be used here (e.g., etomidate,<br />
ketamine, midazolam, propofol, thiopental). Each of these drugs has its own pharmacologic<br />
profile and associated side effects (e.g., etomidate: superficial anesthesia, affects the adrenal<br />
function, ketamine: arterial hypertension, midazolam: slower onset of effect, superficial<br />
anesthesia, propofol: arterial hypotension, thiopental: releases histamine and triggers asthma,<br />
Prehospital – Airway management, ventilation and emergency anesthesia 32
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
necrosis due to extravasation). Ketamine in particular can be used, also in combination with<br />
midazolam or low-dose propofol, for rapid sequence induction in patients with marked<br />
hemodynamic instability [51, 64, 74]. For analgesics, fentanyl or sufentanil is suitable for<br />
patients with stable circulation and ketamine for patients with unstable circulation [51, 64, 74].<br />
Etomidate<br />
Etomidate will be looked at in more detail below because important side effects have been<br />
discussed of late. In a retrospective analysis of the data from a trauma registry, the potentially<br />
negative effects from using etomidate in severe trauma were shown [105]. Etomidate was given<br />
to 35 out of 94 trauma patients (37%) during rapid sequence induction. There were no<br />
differences between the patients treated with and without etomidate in the demographic data<br />
(age: 36 versus 41 years), the cause of trauma, and the injury severity (injury severity score: 26<br />
versus 22). After adjustment of the data (according to physiology, injury severity and<br />
transfusion), etomidate was linked to an increased risk of ARDS and multiple organ failure<br />
(adjusted OR: 3.9, 95% CI: 1.24–12.0). The trauma patients anesthetized with a single dose of<br />
etomidate also had a longer hospital stay (19 versus 22 d, p < 0.02), more ventilation days (11<br />
versus 14 d, p < 0.04) and a longer intensive care stay (13 versus 16 d, p < 0.02).<br />
In another retrospective study of a US trauma registry, the results of the cosyntropin stimulation<br />
test (CST) on 137 trauma patients in intensive care units were examined [23]. 61% of the trauma<br />
patients were non-responders. Age (51 ± 19 versus 50 ± 19 years), sex (male: 38 versus 57%),<br />
trauma mechanism and injury severity (injury severity score: 27 ± 10 versus 31 ± 12, Revised<br />
Trauma Score: 6.5 ± 1.5 versus 5.2 ± 1.8) did not differ significantly between responders and<br />
non-responders. In addition, the rate of sepsis/septic shock (20 versus 34%, p = 0.12), the need<br />
for mechanical ventilation (98 versus 94%, p = 0.38) and the case fatality rate (10 versus 19%,<br />
p = 0.67) did not differ between the two groups. However, there were significant differences in<br />
the incidence of hemorrhagic shock (30 versus 54%, p < 0,005), the need for vasopressors (52<br />
versus 78%, p < 0.002), the incidence of coagulopathies (13 versus 41%, p < 0.001), the period<br />
in intensive care (13 ± 12 versus 19 ± 14, p < 0.007), the number of ventilation days (12 ± 13<br />
versus 17 ± 17, p < 0.006) and the use of etomidate as an induction hypnotic agent (52 versus<br />
71%, p < 0.03). The authors concluded that etomidate is one of the few modifiable risk factors<br />
for the development of adrenocortical insufficiency in critically ill trauma patients.<br />
In another prospective, randomized study, after arriving in a Level I trauma center, trauma<br />
patients received either etomidate and succinylcholine or fentanyl, midazolam and<br />
succinylcholine for rapid sequence induction [50]. The baseline serum cortisol concentration was<br />
recorded before anesthesia induction and an ACTH (adrenocorticotropic hormone) test was<br />
carried out. Altogether, 30 patients were examined. The 18 patients in the etomidate group<br />
showed no significant differences compared to the 12 patients treated with fentanyl/midazolam<br />
with regard to the following patient characteristics (age: 42 ± 25 versus 44 ± 20 years, p = 0.802;<br />
Injury Severity Score: 27 ± 10 versus 20 ± 11 years, p = 0.105; baseline serum cortisol<br />
concentration: 31 ± 12 versus 27 ± 10 µg/dl, p = 0.321). The patients treated with etomidate<br />
showed a slight rise in serum cortisol concentration after the ACTH test compared to the patients<br />
treated with fentanyl/midazolam (4.2 ± 4.9 µg/dl versus 11.2 ± 6.1 µg/dl, p < 0.001). The<br />
patients treated with etomidate had a longer stay in intensive care (8 versus 3 d, p = 0.011), a<br />
Prehospital – Airway management, ventilation and emergency anesthesia 33
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
longer period of ventilation (6.3 versus 1.5 d, p = 0.007) and longer hospital treatment (14 versus<br />
6 d, p = 0.007). Two trauma patients in this study collective died, and both had been treated with<br />
etomidate. The authors concluded that other induction hypnotic agents instead of etomidate<br />
should be used for trauma patients.<br />
Overall, the current data status shows rather unfavorable results for the use of etomidate in<br />
trauma patients. Thus, etomidate should only be used with great care and deliberation in the<br />
induction of trauma patients.<br />
Prehospital – Airway management, ventilation and emergency anesthesia 34
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Procedure for endotracheal intubation with suspected cervical spine injury<br />
Key recommendation:<br />
Manual in-line stabilization should be carried out for endotracheal<br />
intubation with the cervical spine immobilization device temporarily<br />
removed.<br />
Explanation:<br />
GoR B<br />
Normally, trauma patients, particularly multiply injured patients, are immobilized with a neck<br />
brace until a cervical spine fracture can be excluded by imaging technology. However, a<br />
correctly positioned cervical spine immobilization device restricts the mouth opening and thus<br />
the ability to insert a laryngoscope during an intubation maneuver. The cervical spine<br />
immobilization device prevents reclination of the head. Thus, it was possible in a prospective<br />
multi-center study to identify cervical spine immobilization as a cause of a more difficult<br />
endotracheal intubation [58]. For this reason, some users are replacing the cervical spine<br />
immobilization device in endotracheal intubation by manual in-line stabilization (MILS). In this<br />
case, the cervical spine is immobilized by another assistant using both hands to immobilize the<br />
cervical spine manually. The subsequent direct laryngoscopy under MILS was the standard of<br />
care in emergency situations for many years. However, there is controversy surrounding MILS<br />
and partially negative effects have been described [63, 79]. As an alternative to direct<br />
laryngoscopy, fiberoptic intubation as the gold standard can be performed on alert and<br />
spontaneously breathing patients in a stable cardiopulmonary condition by an experienced user<br />
in-hospital [13, 74].<br />
Prehospital – Airway management, ventilation and emergency anesthesia 35
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Albrecht E, Yersin B, Spahn DR et al. (2006) Success<br />
Rate of Airway Management by Residents in a Prehospital<br />
Emergency Setting: a Retrospective Study<br />
Eur J Trauma 32:516-522 [LoE 3b]<br />
2. Amato MB, Barbas CS, Medeiros DM et al. (1995)<br />
Beneficial effects of the "open lung approach" with<br />
low distending pressures in acute respiratory distress<br />
syndrome. A prospective randomized study on<br />
mechanical ventilation. Am J Respir Crit Care Med<br />
152:1835-1846<br />
3. Anonymous (2008) American College of Surgeons<br />
Committee on Trauma ATLS ® Student Course.<br />
Manual 8 Edition [LoE 5]<br />
4. Anonymous (2003) Practice guidelines for<br />
management of the difficult airway: an updated report<br />
by the American Society of Anesthesiologists Task<br />
Force on Management of the Difficult Airway.<br />
Anesthesiology 98:1269-1277 [Evidenzbasierte<br />
Leitlinie]<br />
5. Anonymous (2000) Ventilation with lower tidal<br />
volumes as compared with traditional tidal volumes<br />
for acute lung injury and the acute respiratory distress<br />
syndrome. The Acute Respiratory Distress Syndrome<br />
Network. N Engl J Med 342:1301-1308<br />
6. Arbabi S, Jurkovich GJ, Wahl WL et al. (2004) A<br />
comparison of prehospital and hospital data in trauma<br />
patients. J Trauma 56:1029-1032 [LoE 2b]<br />
7. Aufmkolk M, Ruchholtz S, Hering M et al. (2003)<br />
[The value of subjective estimation of the severity of<br />
thoracic injuries by the emergency surgeon].<br />
Unfallchirurg 106:746-753<br />
8. Badjatia N, Carney N, Crocco TJ et al. (2008)<br />
Guidelines for prehospital management of traumatic<br />
brain injury 2nd edition. Prehosp Emerg Care 12<br />
Suppl 1:S1-52 [Evidenzbasierte Leitlinie]<br />
9. Berlac P, Hyldmo PK, Kongstad P et al. (2008)<br />
Prehospital airway management: guidelines from a<br />
task force from the Scandinavian Society for<br />
Anaesthesiology and Intensive Care Medicine. Acta<br />
Anaesthesiol Scand 52:897-907 [Evidenzbasierte<br />
Leitlinie]<br />
10. Berlot G, La Fata C, Bacer B et al. (2009) Influence of<br />
prehospital treatment on the outcome of patients with<br />
severe blunt traumatic brain injury: a single-centre<br />
study. Eur J Emerg Med 16:312-317 [LoE 4]<br />
11. Bernard S, Smith K, Foster S et al. (2002) The use of<br />
rapid sequence intubation by ambulance paramedics<br />
for patients with severe head injury. Emerg Med<br />
(Fremantle) 14:406-411 [LoE 4]<br />
12. Bochicchio GV, Ilahi O, Joshi M et al. (2003)<br />
Endotracheal intubation in the field does not improve<br />
outcome in trauma patients who present without an<br />
acutely lethal traumatic brain injury. J Trauma<br />
54:307-311 [LoE 5]<br />
13. Bonhomme V, Hans P (2009) Management of the<br />
unstable cervical spine: elective versus emergent<br />
cases. Curr Opin Anaesthesiol 22:579-585<br />
14. Bratton SL, Chestnut RM, Ghajar J et al. (2007)<br />
Guidelines for the management of severe traumatic<br />
brain injury. XIV. Hyperventilation. J Neurotrauma<br />
24 Suppl 1:S87-90 [Evidenzbasierte Leitlinie]<br />
15. Braun U, Goldmann K, Hempel V et al. (2004)<br />
Airway Management. Leitlinien der Deutschen<br />
Gesellschaft für Anästhesiologie und Intensivmedizin.<br />
Anästh Intensivmed 45:302-306 [LoE 5]<br />
16. Bullock MR, Povlishock JT (2007) Guidelines for the<br />
management of severe traumatic brain injury. Editor's<br />
Commentary. J Neurotrauma 24 Suppl 1:2 p<br />
preceding S1 [Evidenzbasierte Leitlinie]<br />
17. Caulfield EV, Dutton RP, Floccare DJ et al. (2009)<br />
Prehospital hypocapnia and poor outcome after severe<br />
traumatic brain injury. J Trauma 66:1577-1582;<br />
discussion 1583 [LoE 3b]<br />
18. Chesnut RM (1997) Avoidance of hypotension:<br />
conditio sine qua non of successful severe head-injury<br />
management. J Trauma 42:S4-9<br />
19. Chesnut RM, Marshall LF, Klauber MR et al. (1993)<br />
The role of secondary brain injury in determining<br />
outcome from severe head injury. J Trauma 34:216-<br />
222<br />
20. Cobas MA, De la Pena MA, Manning R et al. (2009)<br />
Prehospital intubations and mortality: a level 1 trauma<br />
center perspective. Anesth Analg 109:489-493<br />
21. Cogbill TH, Cothren CC, Ahearn MK et al. (2008)<br />
Management of maxillofacial injuries with severe<br />
oronasal hemorrhage: a multicenter perspective. J<br />
Trauma 65:994-999 [LoE 4]<br />
22. Combes X, Jabre P, Jbeili C et al. (2006) Prehospital<br />
standardization of medical airway management:<br />
incidence and risk factors of difficult airway. Acad<br />
Emerg Med 13:828-834 [LoE 3b]<br />
23. Cotton BA, Guillamondegui OD, Fleming SB et al.<br />
(2008) Increased risk of adrenal insufficiency<br />
following etomidate exposure in critically injured<br />
patients. Arch Surg 143:62-67; discussion 67 [LoE<br />
2b]<br />
24. Cudnik MT, Newgard CD, Wang H et al. (2007)<br />
Endotracheal intubation increases out-of-hospital time<br />
in trauma patients. Prehosp Emerg Care 11:224-229<br />
25. Davis DP, Hoyt DB, Ochs M et al. (2003) The effect<br />
of paramedic rapid sequence intubation on outcome in<br />
patients with severe traumatic brain injury. J Trauma<br />
54:444-453 [LoE 5]<br />
26. Dewar D, Moore FA, Moore EE et al. (2009)<br />
Postinjury multiple organ failure. Injury 40:912-918<br />
27. DGAI (1997) Richtlinie der Deutschen Gesellschaft<br />
für Anästhesiologie und Intensivmedizin und des<br />
Berufsverbandes Deutscher Anästhesisten.<br />
Ausstattung des anästhesiologischen Arbeitsplatzes.<br />
Anästh Intensivmed 39:470-474 [LoE 5]<br />
28. DIN (2009) Notarzt-Einsatzfahrzeuge (NEF) -<br />
Begriffe, Anforderungen, Prüfung. Beuth, Berlin<br />
29. DIN (2004) Patiententransportmittel in der Luft, auf<br />
dem Wasser und in schwierigem Gelände - Teil 2:.<br />
Beuth, Berlin<br />
30. DIN (2004) Rettungsdienstfahrzeuge und deren<br />
Ausrüstung - Krankenkraftwagen. Beuth, Berlin<br />
Prehospital – Airway management, ventilation and emergency anesthesia 36
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
31. DiRusso SM, Sullivan T, Risucci D et al. (2005)<br />
Intubation of pediatric trauma patients in the field:<br />
predictor of negative outcome despite risk<br />
stratification. J Trauma 59:84-90; discussion 90-81<br />
[LoE 5]<br />
32. Dunham CM, Barraco RD, Clark DE et al. (2003)<br />
Guidelines for emergency tracheal intubation<br />
immediately after traumatic injury. J Trauma 55:162-<br />
179 [Evidenzbasierte Leitlinie]<br />
33. Dupanovic M, Fox H, Kovac A (2010) Management<br />
of the airway in multitrauma. Curr Opin Anaesthesiol<br />
23:276-282<br />
34. Eckstein M, Chan L, Schneir A et al. (2000) Effect of<br />
prehospital advanced life support on outcomes of<br />
major trauma patients. J Trauma 48:643-648<br />
35. Eich C, Roessler M, Nemeth M et al. (2009)<br />
Characteristics and outcome of prehospital paediatric<br />
tracheal intubation attended by anaesthesia-trained<br />
emergency physicians. Resuscitation 80:1371-1377<br />
[LoE 2a]<br />
36. Ellis DY, Davies GE, Pearn J et al. (2007) Prehospital<br />
rapid-sequence intubation of patients with trauma with<br />
a Glasgow Coma Score of 13 or 14 and the<br />
subsequent incidence of intracranial pathology. Emerg<br />
Med J 24:139-141 [LoE 2b]<br />
37. Fakhry SM, Scanlon JM, Robinson L et al. (2006)<br />
Prehospital rapid sequence intubation for head trauma:<br />
conditions for a successful program. J Trauma 60:997-<br />
1001<br />
38. Frankel H, Rozycki G, Champion H et al. (1997) The<br />
use of TRISS methodology to validate prehospital<br />
intubation by urban EMS providers. Am J Emerg Med<br />
15:630-632 [LoE 4]<br />
39. Franschman G, Peerdeman SM, Greuters S et al.<br />
(2009) Prehospital endotracheal intubation in patients<br />
with severe traumatic brain injury: guidelines versus<br />
reality. Resuscitation 80:1147-1151 [Evidenzbasierte<br />
Leitlinie]<br />
40. Gausche M, Lewis RJ, Stratton SJ et al. (2000) Effect<br />
of out-of-hospital pediatric endotracheal intubation on<br />
survival and neurological outcome: a controlled<br />
clinical trial. JAMA 283:783-790<br />
41. Genzwuerker H, Apfel B, Finteis T et al. (2008)<br />
Intubation by emergency physicians in the field: Rate<br />
of unrecognized oesophageal intubations upon<br />
admission to the trauma room. In: Euroanaesthesia,<br />
The European Anaesthesiology Congress.<br />
Copenhagen, Denmark<br />
42. Genzwuerker H, Lessing P, Ellinger K et al. (2007)<br />
[Infrastructure of emergency medical services.<br />
Comparison of physician-staffed ambulance<br />
equipment in the state of Baden-Wuerttemberg in<br />
2001 and 2005]. Anaesthesist 56:665-672 [LoE 4]<br />
43. Gries A, Sikinger M, Hainer C et al. (2008) [Time in<br />
care of trauma patients in the air rescue service:<br />
implications for disposition?]. Anaesthesist 57:562-<br />
570 [LoE 2a]<br />
44. Grmec S, Mally S (2004) Prehospital determination of<br />
tracheal tube placement in severe head injury. Emerg<br />
Med J 21:518-520 [LoE 3b]<br />
45. Hager DN, Krishnan JA, Hayden DL et al. (2005)<br />
Tidal volume reduction in patients with acute lung<br />
injury when plateau pressures are not high. Am J<br />
Respir Crit Care Med 172:1241-1245<br />
46. Heidegger T, Gerig HJ, Henderson JJ (2005)<br />
Strategies and algorithms for management of the<br />
difficult airway. Best Pract Res Clin Anaesthesiol<br />
19:661-674 [LoE 5]<br />
47. Helm M, Hauke J, Lampl L (2002) A prospective<br />
study of the quality of pre-hospital emergency<br />
ventilation in patients with severe head injury. Br J<br />
Anaesth 88:345-349 [LoE 1a]<br />
48. Helm M, Hossfeld B, Schafer S et al. (2006) Factors<br />
influencing emergency intubation in the pre-hospital<br />
setting--a multicentre study in the German Helicopter<br />
Emergency Medical Service. Br J Anaesth 96:67-71<br />
[LoE 2b]<br />
49. Henderson JJ, Popat MT, Latto IP et al. (2004)<br />
Difficult Airway Society guidelines for management<br />
of the unanticipated difficult intubation. Anaesthesia<br />
59:675-694 [Evidenzbasierte Leitlinie]<br />
50. Hildreth AN, Mejia VA, Maxwell RA et al. (2008)<br />
Adrenal suppression following a single dose of<br />
etomidate for rapid sequence induction: a prospective<br />
randomized study. J Trauma 65:573-579 [LoE 1b]<br />
51. Jabre P, Combes X, Lapostolle F et al. (2009)<br />
Etomidate versus ketamine for rapid sequence<br />
intubation in acutely ill patients: a multicentre<br />
randomised controlled trial. Lancet 374:293-300<br />
[LoE 1b]<br />
52. Jeremitsky E, Omert L, Dunham CM et al. (2003)<br />
Harbingers of poor outcome the day after severe brain<br />
injury: hypothermia, hypoxia, and hypoperfusion. J<br />
Trauma 54:312-319<br />
53. Katz SH, Falk JL (2001) Misplaced endotracheal<br />
tubes by paramedics in an urban emergency medical<br />
services system. Ann Emerg Med 37:32-37<br />
54. Keel M, Eid K, Labler L et al. (2006) Influence of<br />
Injury Pattern on Incidence and Severity of<br />
Posttraumatic Inflammatory Complications in<br />
Severely Injured Patients. Eur J Trauma 32:387-395<br />
55. Keul W, Bernhard M, Volkl A et al. (2004) [Methods<br />
of airway management in prehospital emergency<br />
medicine]. Anaesthesist 53:978-992<br />
56. Klemen P, Grmec S (2006) Effect of pre-hospital<br />
advanced life support with rapid sequence intubation<br />
on outcome of severe traumatic brain injury. Acta<br />
Anaesthesiol Scand 50:1250-1254 [LoE 4]<br />
57. Konrad C, Schupfer G, Wietlisbach M et al. (1998)<br />
Learning manual skills in anesthesiology: Is there a<br />
recommended number of cases for anesthetic<br />
procedures? Anesth Analg 86:635-639 [LoE 3b]<br />
58. Lackner CK, Reith MW, Ruppert M (2002)<br />
Präklinische Intubation und Verifikation der<br />
endotrachealen Tubuslage – Eine prospektive<br />
multizentrische Studie zum Stellenwert der<br />
Kapnografie. Notfall- und Rettungsmedizin 5:430-440<br />
59. Lavery GG, McCloskey BV (2008) The difficult<br />
airway in adult critical care. Crit Care Med 36:2163-<br />
2173<br />
60. Lecky F, Bryden D, Little R et al. (2008) Emergency<br />
intubation for acutely ill and injured patients.<br />
Cochrane Database Syst Rev:CD001429 [LoE 5]<br />
Prehospital – Airway management, ventilation and emergency anesthesia 37
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
61. Lee SW, Hong YS, Han C et al. (2009) Concordance<br />
of end-tidal carbon dioxide and arterial carbon dioxide<br />
in severe traumatic brain injury. J Trauma 67:526-530<br />
[LoE 2a]<br />
62. Liberman M, Roudsari BS (2007) Prehospital trauma<br />
care: what do we really know? Curr Opin Crit Care<br />
13:691-696 [LoE 5]<br />
63. Manoach S, Paladino L (2007) Manual in-line<br />
stabilization for acute airway management of<br />
suspected cervical spine injury: historical review and<br />
current questions. Ann Emerg Med 50:236-245 [LoE<br />
5]<br />
64. Morris C, Perris A, Klein J et al. (2009) Anaesthesia<br />
in haemodynamically compromised emergency<br />
patients: does ketamine represent the best choice of<br />
induction agent? Anaesthesia 64:532-539<br />
65. Mort TC (2004) Emergency tracheal intubation:<br />
complications associated with repeated laryngoscopic<br />
attempts. Anesth Analg 99:607-613, table of contents<br />
66. Mort TC (2005) Esophageal intubation with indirect<br />
clinical tests during emergency tracheal intubation: a<br />
report on patient morbidity. J Clin Anesth 17:255-262<br />
[LoE 3b]<br />
67. Mort TC (2005) Preoxygenation in critically ill<br />
patients requiring emergency tracheal intubation. Crit<br />
Care Med 33:2672-2675 [LoE 2b]<br />
68. Mort TC, Waberski BH, Clive J (2009) Extending the<br />
preoxygenation period from 4 to 8 mins in critically ill<br />
patients undergoing emergency intubation. Crit Care<br />
Med 37:68-71 [LoE 2b]<br />
69. Murray JA, Demetriades D, Berne TV et al. (2000)<br />
Prehospital intubation in patients with severe head<br />
injury. J Trauma 49:1065-1070 [LoE 5]<br />
70. Mutzbauer TS, Bernhard M, Doll S et al. (2008) Die<br />
notfallmäßige Koniotomie. Notfall- und<br />
Rettungsmedizin 11:310-316<br />
71. NAEMT (2009) Präklinisches Traumamanagement:<br />
Das PHTLS ® -Konzept. Elsevier, München [LoE 5]<br />
72. Newton A, Ratchford A, Khan I (2008) Incidence of<br />
adverse events during prehospital rapid sequence<br />
intubation: a review of one year on the London<br />
Helicopter Emergency Medical Service. J Trauma<br />
64:487-492 [LoE 4]<br />
73. Nolan JP, Deakin CD, Soar J et al. (2005) European<br />
Resuscitation Council guidelines for resuscitation<br />
2005. Section 4. Adult advanced life support.<br />
Resuscitation 67 Suppl 1:<strong>S3</strong>9-86 [Evidenzbasierte<br />
Leitlinie]<br />
74. Paal P, Herff H, Mitterlechner T et al. (2010)<br />
Anaesthesia in prehospital emergencies and in the<br />
emergency room. Resuscitation 81:148-154 [LoE 5]<br />
75. Pelucio M, Halligan L, Dhindsa H (1997) Out-ofhospital<br />
experience with the syringe esophageal<br />
detector device. Acad Emerg Med 4:563-568<br />
76. Rivara FP, Maier RV, Mueller BA et al. (1989)<br />
Evaluation of potentially preventable deaths among<br />
pedestrian and bicyclist fatalities. JAMA 261:566-570<br />
77. Ruchholtz S, Lefering R, Paffrath T et al. (2008)<br />
Reduction in mortality of severely injured patients in<br />
Germany. Dtsch Arztebl Int 105:225-231<br />
78. Ruchholtz S, Waydhas C, Ose C et al. (2002)<br />
Prehospital intubation in severe thoracic trauma<br />
without respiratory insufficiency: a matched-pair<br />
analysis based on the Trauma Registry of the German<br />
Trauma Society. J Trauma 52:879-886 [LoE 3b]<br />
79. Santoni BG, Hindman BJ, Puttlitz CM et al. (2009)<br />
Manual in-line stabilization increases pressures<br />
applied by the laryngoscope blade during direct<br />
laryngoscopy and orotracheal intubation.<br />
Anesthesiology 110:24-31 [LoE 3b]<br />
80. Schlechtriemen T, Reeb R, Ensle G et al. (2004)<br />
Überprüfung der korrekten Tubuslage in der<br />
Notfallmedizin. Notfall- und Rettungsmedizin 7:231-<br />
236<br />
81. Schmidt UH, Kumwilaisak K, Bittner E et al. (2008)<br />
Effects of supervision by attending anesthesiologists<br />
on complications of emergency tracheal intubation.<br />
Anesthesiology 109:973-977 [LoE 4]<br />
82. Shah CV, Localio AR, Lanken PN et al. (2008) The<br />
impact of development of acute lung injury on<br />
hospital mortality in critically ill trauma patients. Crit<br />
Care Med 36:2309-2315<br />
83. Silvestri S, Ralls GA, Krauss B et al. (2005) The<br />
effectiveness of out-of-hospital use of continuous endtidal<br />
carbon dioxide monitoring on the rate of<br />
unrecognized misplaced intubation within a regional<br />
emergency medical services system. Ann Emerg Med<br />
45:497-503 [LoE 3b]<br />
84. Sing RF, Rotondo MF, Zonies DH et al. (1998) Rapid<br />
sequence induction for intubation by an aeromedical<br />
transport team: a critical analysis. Am J Emerg Med<br />
16:598-602<br />
85. Sise MJ, Shackford SR, Sise CB et al. (2009) Early<br />
intubation in the management of trauma patients:<br />
indications and outcomes in 1,000 consecutive<br />
patients. J Trauma 66:32-39; discussion 39-40 [LoE<br />
2b]<br />
86. Sloane C, Vilke GM, Chan TC et al. (2000) Rapid<br />
sequence intubation in the field versus hospital in<br />
trauma patients. J Emerg Med 19:259-264<br />
87. Stahel PF, Smith WR, Moore EE (2008) Hypoxia and<br />
hypotension, the "lethal duo" in traumatic brain<br />
injury: implications for prehospital care. Intensive<br />
Care Med 34:402-404<br />
88. Stephens CT, Kahntroff S, Dutton RP (2009) The<br />
success of emergency endotracheal intubation in<br />
trauma patients: a 10-year experience at a major adult<br />
trauma referral center. Anesth Analg 109:866-872<br />
[LoE 4]<br />
89. Stiell IG, Nesbitt LP, Pickett W et al. (2008) The<br />
OPALS Major Trauma Study: impact of advanced<br />
life-support on survival and morbidity. CMAJ<br />
178:1141-1152<br />
90. Stocchetti N, Furlan A, Volta F (1996) Hypoxemia<br />
and arterial hypotension at the accident scene in head<br />
injury. J Trauma 40:764-767 [LoE 4]<br />
91. Suominen P, Baillie C, Kivioja A et al. (2000)<br />
Intubation and survival in severe paediatric blunt head<br />
injury. Eur J Emerg Med 7:3-7 [LoE 4]<br />
92. Thierbach A, Piepho T, Wolcke B et al. (2004)<br />
[Prehospital emergency airway management<br />
Prehospital – Airway management, ventilation and emergency anesthesia 38
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
procedures. Success rates and complications].<br />
Anaesthesist 53:543-550 [LoE 2a]<br />
93. Timmermann A, Braun U, Panzer W et al. (2007)<br />
[Out-of-hospital airway management in northern<br />
Germany. Physician-specific knowledge, procedures<br />
and equipment]. Anaesthesist 56:328-334 [LoE 4]<br />
94. Timmermann A, Eich C, Russo SG et al. (2006)<br />
Prehospital airway management: a prospective<br />
evaluation of anaesthesia trained emergency<br />
physicians. Resuscitation 70:179-185 [LoE 3b]<br />
95. Timmermann A, Russo SG, Eich C et al. (2007) The<br />
out-of-hospital esophageal and endobronchial<br />
intubations performed by emergency physicians.<br />
Anesth Analg 104:619-623 [LoE 3b]<br />
96. Tracy S, Schinco MA, Griffen MM et al. (2006)<br />
Urgent airway intervention: does outcome change<br />
with personnel performing the procedure? J Trauma<br />
61:1162-1165 [LoE 2b]<br />
97. Trupka A, Waydhas C, Nast-Kolb D et al. (1995)<br />
[Effect of early intubation on the reduction of posttraumatic<br />
organ failure]. Unfallchirurg 98:111-117<br />
98. von Elm E, Schoettker P, Henzi I et al. (2009) Prehospital<br />
tracheal intubation in patients with traumatic<br />
brain injury: systematic review of current evidence. Br<br />
J Anaesth 103:371-386 [LoE 5]<br />
99. Wang HE, Cook LJ, Chang CC et al. (2009)<br />
Outcomes after out-of-hospital endotracheal<br />
intubation errors. Resuscitation 80:50-55<br />
100. Wang HE, Sweeney TA, O'Connor RE et al. (2001)<br />
Failed prehospital intubations: an analysis of<br />
emergency department courses and outcomes. Prehosp<br />
Emerg Care 5:134-141 [LoE 5]<br />
101. Wang HE, Yealy DM (2006) How many attempts are<br />
required to accomplish out-of-hospital endotracheal<br />
intubation? Acad Emerg Med 13:372-377 [LoE 1b]<br />
102. Warner KJ, Cuschieri J, Copass MK et al. (2008)<br />
Emergency department ventilation effects outcome in<br />
severe traumatic brain injury. J Trauma 64:341-347<br />
[LoE 4]<br />
103. Warner KJ, Cuschieri J, Copass MK et al. (2007) The<br />
impact of prehospital ventilation on outcome after<br />
severe traumatic brain injury. J Trauma 62:1330-<br />
1336; discussion 1336-1338 [LoE 2a]<br />
104. Warner KJ, Cuschieri J, Garland B et al. (2009) The<br />
utility of early end-tidal capnography in monitoring<br />
ventilation status after severe injury. J Trauma 66:26-<br />
31 [LoE 4]<br />
105. Warner KJ, Cuschieri J, Jurkovich GJ et al. (2009)<br />
Single-dose etomidate for rapid sequence intubation<br />
may impact outcome after severe injury. J Trauma<br />
67:45-50<br />
106. Wayne MA, Friedland E (1999) Prehospital use of<br />
succinylcholine: a 20-year review. Prehosp Emerg<br />
Care 3:107-109<br />
107. Wolfl CG, Gliwitzky B, Wentzensen A (2009)<br />
[Standardised primary care of multiple trauma<br />
patients. Prehospital Trauma Life Support und<br />
Advanced Trauma Life Support]. Unfallchirurg<br />
112:846-853<br />
Prehospital – Airway management, ventilation and emergency anesthesia 39
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.3 Volume replacement<br />
Key recommendations:<br />
Volume replacement should be introduced in severely injured patients, at a<br />
reduced level if there is uncontrollable bleeding, in order to keep the<br />
circulation at a low stable level and not exacerbate the bleeding.<br />
Volume replacement should be carried out with the aim of restoring<br />
normotension in hypotensive patients with traumatic brain injury.<br />
Normotensive patients do not require volume replacement but venous lines<br />
should be placed.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
GoR B<br />
Due to underperfusion from hemorrhaging and consecutively occurring traumatic-hemorrhagic<br />
shock, there is an imbalance between oxygen supply and demand in the tissue [83]. This<br />
disturbed microcirculation is held responsible for the occurrence of secondary damage following<br />
hemorrhagic shock. The goal of volume replacement should be to improve microcirculation and<br />
thus organ perfusion. Expert opinion therefore holds that aggressive volume replacement has a<br />
favorable effect on the outcome for acutely bleeding patients [1, 28, 53, 56]. This rationale for<br />
the prehospital phase has not been confirmed in randomized controlled trials. In a randomized<br />
controlled trial [83], prehospital patients were randomized either to receive or not receive<br />
volume replacement. 1,309 patients were included. There was no difference between the groups<br />
in terms of mortality, morbidity and long-term outcome [83].<br />
In a retrospective study by Balogh et al. [8], 156 patients in shock receiving supranormal<br />
resuscitation were compared to patients receiving less treatment which was terminated at the<br />
oxygen delivery index (DO2I) . Raised intraabdominal pressure, which is supposed to be<br />
associated with increased organ failure, was observed in the aggressive intervention group.<br />
Another study by Bickell et al. [11] found a negative survival effect from volume replacement<br />
after bleeding. However, this study only included patients with penetrating torso injuries. 1,069<br />
patients were included in the study. In this selected patient group, the introduction of volume<br />
replacement in the prehospital phase led to an increase in mortality from 30% to 38% and to an<br />
increase from 23% to 30% in post-operative complications in the group with prehospital volume<br />
replacement. The authors concluded from this that prehospital volume replacement should not be<br />
carried out and that surgical treatment should be started as quickly as possible. Many authors go<br />
along with this conclusion in reviews or experimental studies [9, 45, 48, 60, 67, 77, 82].<br />
However, the authors always highlight there being uncontrollable intrathoracic or intraabdominal<br />
bleeding. In such a situation, surgery should be performed as rapidly as possible and not be<br />
delayed by prehospital interventions. The goal should be moderate volume replacement with<br />
“controlled hypotension” and a systolic blood pressure of about 90 mmHg should be aimed for<br />
Prehospital – Volume replacement 40
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
[10, 36, 51, 69]. However, even this is questioned in patients with cardiac damage or traumatic<br />
brain injury (TBI) [35, 51, 79]. On the other hand, other authors partly advocate aggressive<br />
volume replacement, often addressing a different set of patients with, for example, extremity<br />
injuries without uncontrollable bleeding [28, 52, 56, 61, 71]. More recent papers have been<br />
unable to confirm the results obtained by Bickell [44, 94].<br />
The majority of papers recommend the introduction of intensive volume replacement upon<br />
arrival at the hospital and after surgery has begun or if there is controllable bleeding. Again,<br />
expert opinion indicates a target hematocrit value of 25-30% as the volume to be administered<br />
[12, 40, 55, 56]. Controlled studies on this topic do not exist.<br />
The use of catecholamines is viewed critically and only seen as a last resort [46, 56].<br />
In one study, the extended prehospital treatment time due to carrying out volume replacement is<br />
given as 12-13 minutes [83]. The authors interpret this time loss partly as of little relevance [83]<br />
and partly as a major negative factor for mortality [73]. However, it is unclear whether this<br />
statement from North America can be transferred to the conditions of the German emergency<br />
physician-supported system.<br />
Table 3: Prehospital volume replacement - mortality<br />
Study LoE Patient collective<br />
Turner et al. 2000<br />
[83]<br />
Bickell et al. 1994<br />
[11]<br />
1b<br />
2a<br />
Multiply injured patients<br />
(n = 1,309)<br />
Patients with penetrating chest<br />
injury (n = 1,069)<br />
Mortality with<br />
volume<br />
replacement<br />
Mortality without<br />
volume<br />
replacement<br />
10.4% 9.8%<br />
38% 30%<br />
Prehospital – Volume replacement 41
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Crystalloids versus colloids<br />
Key recommendations:<br />
Crystalloids should be used for volume replacement in trauma patients. GoR B<br />
Isotonic saline solution should not be used; preference should be given to<br />
Ringer’s malate, or alternatively Ringer’s acetate or lactated Ringer's<br />
solution.<br />
GoR B<br />
Human albumin must not be used in prehospital volume replacement. GoR A<br />
If colloidal solutions are used in hypotensive trauma patients, preference<br />
should be given to HES 130/0.4.<br />
Explanation:<br />
GoR B<br />
There is still controversy surrounding the choice of infusion solution to be used. The majority of<br />
data is taken from animal experiments or from operations and is limited in its evidential value.<br />
Different results are produced from the meta-analyses carried out. In 1989, Velanovich et al.<br />
showed a reduction of 12.3% in mortality of trauma patients when crystalloid volume<br />
replacement was given [85]. In 1999, Choi et al. confirmed this result and hypothesized a lower<br />
mortality after trauma when crystalloids were used [23]. A Cochrane analysis of 2008 yielded no<br />
difference between colloids and crystalloids after trauma [19, 20, 21]. The authors concluded<br />
from this that colloids could be dispensed with as a volume replacement drug as there was no<br />
evidence of an advantage from colloids, and crystalloids were cheaper. A proviso should be<br />
mentioned here that old, very large-molecule solutions were used in these reviews and the<br />
informative value of these reviews is limited. According to the available studies, the newer<br />
colloid hydroxy ethyl starch (HES) 1301/0.4 no longer seems to have the disadvantages of older<br />
starch solutions [39, 53]. However, a marked deterioration in coagulation was observed in one<br />
in-vitro study even for more modern volume solutions including hypertonic saline solution. This<br />
effect was not observed when using lactated Ringer's solution or 0.9% saline solution [14].<br />
Lactated Ringer’s solution is the preferred choice of crystalloid over isotonic saline solution [30,<br />
41, 43, 78]. Experimental papers showed evidence of dilutional acidosis occurring after infusion<br />
of large amounts of isotonic saline solution [62, 63]. The addition of lactate to a Ringer’s<br />
balanced electrolyte solution prevents dilutional acidosis through the metabolization of the<br />
lactate to bicarbonate and water, thus buffering the bicarbonate pool. More recent experimental<br />
papers have found evidence of disadvantages in lactated Ringer's solution. According to these<br />
papers, lactated Ringer's solution triggers the activation of neutrophil granulocytes, thus causing<br />
more lung damage [4, 5, 6, 66]. The rate of granulocyte apoptosis is also apparently increased<br />
[32]. There is no evidence of this in clinical studies.<br />
Prehospital – Volume replacement 42
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Plasma lactate is used as a shock parameter in diagnosis. Lactated Ringer's solution leads to an<br />
iatrogenic increase in plasma lactate level and can thus interfere with the diagnosis [64, 65].<br />
Ringer’s malate or Ringer’s acetate can be used instead. In animal experiments there was<br />
evidence of lower mortality with Ringer’s malate. In conclusion, the use of lactated Ringer's<br />
solution no longer appears to be worthy of recommendation.<br />
A Cochrane Review did not identify any evidence that one colloid is significantly superior to the<br />
other in the choice of colloid to be used [18]. The risk of an anaphylactic reaction to a colloid<br />
can be classified as minimal. In 1997, Ring [68] published his findings in The Lancet on the<br />
probability of an immune reaction to HES as 0.006%, to dextran as 0.0008% and to gelatine as<br />
0.038%. Individual research papers seem to want to see an advantage of HES over the other<br />
colloids [1, 54, 74]. In a large series in France, the tolerance of different colloids was studied in<br />
19,593 patients. 48.1% received gelatine solutions, 27.6% starch solutions, 15.7% albumin, and<br />
9.5% dextrans. Overall, 43 anaphylactic reactions were observed (0.219%). The distribution<br />
between the different volume solutions was as follows: 0.345% for gelatine, 0.273% for<br />
dextrans, 0.099% for albumin, and 0.058% for starch. 20% of all allergic reactions were serious<br />
to very serious (grade III and IV). In a multivariate analysis, independent risk factors were<br />
identified as the administration of gelatine (OR 4.81), dextran (OR 3.83), a medical history of<br />
allergy to drugs (OR 3.16), and male sex (OR 1.98). Thus, a 6-fold smaller risk of anaphylaxis<br />
was observed for starch solutions compared to gelatine and a 4.7 times lower risk for dextran<br />
[54].<br />
In 1990, Hankeln et al. tested HES 200/0.6 compared to human albumin in a randomized study<br />
of 40 patients with vascular interventions and were able to establish an optimum volume effect<br />
for HES 200/0.6 [41]. According to other studies as well, human albumin as a colloid seems to<br />
be associated with increased mortality and is not to be recommended [41]. The influence of<br />
colloids on coagulation seems negligible [53]. Albumin does not appear to play a role in volume<br />
replacement [37].<br />
Prehospital – Volume replacement 43
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Hypertonic solutions<br />
Key recommendation:<br />
Hypertonic solutions can be used in multiply injured patients with hypotensive<br />
circulation after blunt trauma.<br />
Hypertonic solutions should be used in penetrating trauma if prehospital<br />
volume replacement is carried out.<br />
A hypertonic solution can be used in hypotensive patients with severe<br />
traumatic brain injury.<br />
Explanation:<br />
GoR 0<br />
GoR B<br />
GoR 0<br />
In recent years, the hypertonic 7.5% saline solution has increasingly gained in importance,<br />
especially in prehospital volume replacement. As already described above, the microcirculatory<br />
disturbance is the harmful factor in hemorrhagic-traumatic shock.<br />
The mechanism of action of the hypertonic solution is based on mobilizing intracellular and<br />
interstitial fluid into the intravasal space and thus on improving microcirculation and total<br />
rheology.<br />
The dosage of hypertonic solution is limited in order to counteract harmful hypernatremia. Based<br />
mainly on experimental papers, the optimum dosage has been established at 4 ml/kg body weight<br />
(BW). A single administration is prescribed.<br />
Microcirculatory disturbance during hemorrhaging is the main factor for late complications<br />
occurring. Hypertonic saline solution leads to interstitial and intracellular volume rapidly<br />
mobilizing into the intravasal space and thus to consecutively improving rheology and thereby<br />
the microcirculatory system [49]. No significant advantages of hypertonic solution have been<br />
found in controlled studies. Bunn et al. (2004) studied hypertonic versus isotonic solutions in a<br />
Cochrane Review [20]. The authors came to the conclusion that the available data was still<br />
insufficient to make a <strong>final</strong> judgment on hypertonic solution. In two controlled randomized trials,<br />
Mattox et al. (1991) and Vassar et al. (1991) argued an advantage of hypertonic solution for<br />
survival especially after traumatic brain injury [59, 84]. A paper by Alpar et al. (2004) follows<br />
the same line where an improvement in outcome is described in 180 patients especially after<br />
traumatic brain injury [2]. However, another controlled study from 2004 revealed that there was<br />
no significant difference to be observed in 229 patients in the long-term outcome after traumatic<br />
brain injury [29]. Moreover, Vassar et al. (1993) reported that the addition of dextrans did not<br />
bring any benefit for survival after trauma and bleeding [84]. This finding is contradicted by<br />
several papers which found a clear benefit from the addition of dextran [28, 49, 86, 87].<br />
A positive effect on the clinical treatment of traumatic brain injury has been found in other<br />
studies. Wade (1997) and Vassar (1993) showed an effect on mortality after traumatic brain<br />
Prehospital – Volume replacement 44
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
injury and initial treatment with hypertonic solution [84, 90]. Vassar found that the mortality rate<br />
dropped from 49 to 60% and Wade’s mortality rate from 26.9 to 37.0% with hypertonic solution.<br />
In the follow-up treatment for increased intracranial pressure, a lowering effect is described<br />
particularly for the combination of hypertonic solution/HES [42, 47, 75, 91, 92, 93]. However,<br />
this effect could not be confirmed in a controlled clinical trial [76]. Nor could any advantage<br />
from the hypertonic solution be detected in another current paper by Bulger et al. published in<br />
JAMA with the result that the study was discontinued after 1,313 patients [15]. Wade et al.<br />
conducted a comparative study in terms of a short meta-analysis of 14 papers on hypertonic<br />
saline solution with and without the addition of dextran and found no relevant advantage in<br />
hypertonic solutions [90]. In a paper from 2003, the same author describes a positive effect of<br />
hypertonic solutions in penetrating traumas. In a double-blind study with 230 patients, the<br />
patients initially received either hypertonic sodium chloride (NaCl) or isotonic solution. The<br />
mortality of the patients who were treated with hypertonic NaCl solution was 82.5% versus<br />
75.5%, which was a significant improvement. The surgery rate and bleeding rate were equal. The<br />
authors thus concluded that hypertonic solutions improve the survival rate in penetrating traumas<br />
without increasing bleeding [89].<br />
In a current study by Bulger et al. [17], lactated Ringer's solution was compared to hypertonic<br />
NaCl solution with dextran in a group of 209 multiply injured patients with blunt trauma. The<br />
endpoint of this study was ARDS-free survival. As there were no differences, the study was<br />
discontinued after an intention-to-treat analysis. In a subgroup analysis, an advantage for<br />
hypertonic NaCl solution with dextran was only found after massive transfusion. Even the most<br />
recent publication from this working group did not show any advantages for hypertonic solutions<br />
after hemorrhagic shock [16]. In fact, a higher mortality rate was observed in patients not<br />
requiring transfusion after being given hypertonic solution [28-day mortality-- hypertonic<br />
solution with dextrans: 10%; hypertonic solution: 12.2% and 0.9% saline solution: 4.8%,<br />
p < 0.01) [16].<br />
Immunologic effects are likewise ascribed to the hypertonic solution. Thus, experimental papers<br />
describe a reduction in neutrophil activation and in the pro-inflammatory cascade [4, 5, 6, 7, 26,<br />
27, 31, 33, 66, 81]. No evidence has yet been found on the clinical importance of these effects.<br />
Hypertonic solutions lead to a rapid rise in blood pressure and a reduction in volume requirement<br />
[3, 13, 22, 24, 38, 50, 57, 58, 93]. How far this influences the treatment outcome cannot be found<br />
in the literature.<br />
With regard to the dosage, Rocha and Silva (1990) showed in dogs that a 7.5% solution with<br />
4 ml/kg BW corresponds to the optimum dosage [70]; this was confirmed again by Wade et al.<br />
(2003) [88].<br />
Anti-shock trousers<br />
Key recommendation:<br />
Anti-shock trousers must not be used for circulatory support in multiply GoR A<br />
Prehospital – Volume replacement 45
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
injured patients.<br />
Explanation:<br />
The anti-shock trousers (pneumatic anti-shock garment [PASG]) were promoted particularly in<br />
the 1980s and were often used in the military sector. Soft tissue damage and compartment<br />
syndromes brought their use into question. The current Cochrane Review from the year 2000 no<br />
longer recommends the use of anti-shock trousers. There are indications that the PASG increases<br />
mortality and extends the period of intensive treatment and hospital treatment [34]. Relevant<br />
complications after using anti-shock trousers have been described in several reviews and original<br />
papers [25, 80]. According to the literature available, the PASG should no longer be<br />
recommended.<br />
Prehospital – Volume replacement 46
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Adams Ha, Piepenbrock S, Hempelmann G (1998)<br />
[Volume replacement solutions--pharmacology and<br />
clinical use]. Anasthesiol Intensivmed Notfallmed<br />
Schmerzther 33:2-17 [LoE 5]<br />
2. Alpar Ek, Killampalli Vv (2004) Effects of<br />
hypertonic dextran in hypovolaemic shock: a<br />
prospective clinical trial. Injury 35:500-506 [LoE<br />
1b]<br />
3. Anderson Jt, Wisner Dh, Sullivan Pe et al. (1997)<br />
Initial small-volume hypertonic resuscitation of<br />
shock and brain injury: short- and long-term effects.<br />
J Trauma 42:592-600; discussion 600-591 [LoE 5]<br />
4. Angle N, Cabello-Passini R, Hoyt Db et al. (2000)<br />
Hypertonic saline infusion: can it regulate human<br />
neutrophil function? Shock 14:503-508 [LoE 2b]<br />
5. Angle N, Hoyt Db, Cabello-Passini R et al. (1998)<br />
Hypertonic saline resuscitation reduces neutrophil<br />
margination by suppressing neutrophil L selectin<br />
expression. J Trauma 45:7-12; discussion 12-13<br />
[LoE 5]<br />
6. Angle N, Hoyt Db, Coimbra R et al. (1998)<br />
Hypertonic saline resuscitation diminishes lung<br />
injury by suppressing neutrophil activation after<br />
hemorrhagic shock. Shock 9:164-170 [LoE 5]<br />
7. Assalia A, Bitterman H, Hirsh Tm et al. (2001)<br />
Influence of hypertonic saline on bacterial<br />
translocation in controlled hemorrhagic shock.<br />
Shock 15:307-311 [LoE 5]<br />
8. Balogh Z, Mckinley Ba, Cocanour Cs et al. (2003)<br />
Supranormal trauma resuscitation causes more cases<br />
of abdominal compartment syndrome. Arch Surg<br />
138:637-642; discussion 642-633 [LoE 2a]<br />
9. Banerjee A, Jones R (1994) Whither immediate<br />
fluid resuscitation? Lancet 344:1450-1451 [LoE 5]<br />
10. Beekley AC. Damage control resuscitation: a<br />
sensible approach to the exsanguinating surgical<br />
patient. Crit Care Med. 2008;36:S267-S274 [LoE 5]<br />
11. Bickell Wh, Wall Mj, Jr., Pepe Pe et al. (1994)<br />
Immediate versus delayed fluid resuscitation for<br />
hypotensive patients with penetrating torso injuries.<br />
N Engl J Med 331:1105-1109 [LoE 2a]<br />
12. Brinkmeyer Sd (1983) Fluid resuscitation: an<br />
overview. J Am Osteopath Assoc 82:326-330 [LoE<br />
5]<br />
13. Brock H, Rapf B, Necek S et al. (1995)<br />
[Comparison of postoperative volume therapy in<br />
heart surgery patients]. Anaesthesist 44:486-492<br />
[LoE 1b]<br />
14. Brummel-Ziedins K, Whelihan Mf, Ziedins Eg et al.<br />
(2006) The resuscitative fluid you choose may<br />
potentiate bleeding. J Trauma 61:1350-1358 [LoE<br />
5]<br />
15. Bulger EM, May S, Brasel KJ, Schreiber M, Kerby<br />
JD, Tisherman SA, Newgard C, Slutsky A, Coimbra<br />
R, Emerson S, Minei JP, Bardarson B, Kudenchuk<br />
P, Baker A, Christenson J, Idris A, Davis D, Fabian<br />
TC, Aufderheide TP, Callaway C, Williams C,<br />
Banek J, Vaillancourt C, van Heest R, Sopko G,<br />
Hata JS, Hoyt DB; ROC Investigators. Out-ofhospital<br />
hypertonic resuscitation following severe<br />
traumatic brain injury: a randomized controlled trial.<br />
JAMA. 2010 Oct 6;304(13):1455-64 [LoE 1b]<br />
16. Bulger EM, May S, Kerby JD, Emerson S, Stiell<br />
IG, Schreiber MA, Brasel KJ, Tisherman SA,<br />
Coimbra R, Rizoli S, Minei JP, Hata JS, Sopko G,<br />
Evans DC, Hoyt DB; ROC investigators. Out-ofhospital<br />
hypertonic resuscitation after traumatic<br />
hypovolemic shock: a randomized, placebo<br />
controlled trial. Ann Surg. 2011 Mar;253(3):431-41<br />
[LoE 1b]<br />
17. Bulger Em, Jurkovich Gj, Nathens Ab et al. (2008)<br />
Hypertonic resuscitation of hypovolemic shock after<br />
blunt trauma: a randomized controlled trial. Arch<br />
Surg 143:139-148; discussion 149 [LoE 1b]<br />
18. Bunn F, Kwan I, Roberts I et al. (2001)<br />
Effectiveness of pre-hospital trauma care. Report to<br />
the World Health Organisation Pre-Hospital Care<br />
Steering Committee. . In:<br />
19. Bunn F, Roberts I, Tasker R et al. (2002)<br />
Hypertonic versus isotonic crystalloid for fluid<br />
resuscitation in critically ill patients. Cochrane<br />
Database Syst Rev:CD002045<br />
20. Bunn F, Roberts I, Tasker R et al. (2004)<br />
Hypertonic versus near isotonic crystalloid for fluid<br />
resuscitation in critically ill patients. Cochrane<br />
Database Syst Rev:CD002045 [LoE 1a]<br />
21. Bunn F, Trivedi D, Ashraf S (2008) Colloid<br />
solutions for fluid resuscitation. Cochrane Database<br />
Syst Rev:CD001319 [LoE 1a]<br />
22. Chiara O, Pelosi P, Brazzi L et al. (2003)<br />
Resuscitation from hemorrhagic shock:<br />
experimental model comparing normal saline,<br />
dextran, and hypertonic saline solutions. Crit Care<br />
Med 31:1915-1922 [LoE 5]<br />
23. Choi Pt, Yip G, Quinonez Lg et al. (1999)<br />
Crystalloids vs. colloids in fluid resuscitation: a<br />
systematic review. Crit Care Med 27:200-210 [LoE<br />
1b]<br />
24. Christ F, Niklas M, Kreimeier U et al. (1997)<br />
Hyperosmotic-hyperoncotic solutions during<br />
abdominal aortic aneurysm (AAA) resection. Acta<br />
Anaesthesiol Scand 41:62-70<br />
25. Christensen Ks (1986) Pneumatic antishock<br />
garments (PASG): do they precipitate lowerextremity<br />
compartment syndromes? J Trauma<br />
26:1102-1105 [LoE 3b]<br />
26. Coimbra R, Hoyt Db, Junger Wg et al. (1997)<br />
Hypertonic saline resuscitation decreases<br />
susceptibility to sepsis after hemorrhagic shock. J<br />
Trauma 42:602-606; discussion 606-607 [LoE 5]<br />
27. Coimbra R, Loomis W, Melbostad H et al. (2005)<br />
Role of hypertonic saline and pentoxifylline on<br />
neutrophil activation and tumor necrosis factoralpha<br />
synthesis: a novel resuscitation strategy. J<br />
Trauma 59:257-264; discussion 264-255 [LoE 5]<br />
Prehospital – Volume replacement 47
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
28. Conte Ma (1997) Fluid resuscitation in the trauma<br />
patient. CRNA 8:31-39 [LoE 5]<br />
29. Cooper Dj, Myles Ps, Mcdermott Ft et al. (2004)<br />
Prehospital hypertonic saline resuscitation of<br />
patients with hypotension and severe traumatic<br />
brain injury: a randomized controlled trial. JAMA<br />
291:1350-1357 [LoE 1b]<br />
30. Coran Ag, Ballantine Tv, Horwitz Dl et al. (1971)<br />
The effect of crystalloid resuscitation in<br />
hemorrhagic shock on acid-base balance: a<br />
comparison between normal saline and Ringer's<br />
lactate solutions. Surgery 69:874-880 [LoE 5]<br />
31. Corso Co, Okamoto S, Ruttinger D et al. (1999)<br />
Hypertonic saline dextran attenuates leukocyte<br />
accumulation in the liver after hemorrhagic shock<br />
and resuscitation. J Trauma 46:417-423 [LoE 5]<br />
32. Deb S, Martin B, Sun L et al. (1999) Resuscitation<br />
with lactated Ringer's solution in rats with<br />
hemorrhagic shock induces immediate apoptosis. J<br />
Trauma 46:582-588; discussion 588-589 [LoE 5]<br />
33. Deitch Ea, Shi Hp, Feketeova E et al. (2003)<br />
Hypertonic saline resuscitation limits neutrophil<br />
activation after trauma-hemorrhagic shock. Shock<br />
19:328-333 [LoE 5]<br />
34. Dickinson K, Roberts I (2000) Medical anti-shock<br />
trousers (pneumatic anti-shock garments) for<br />
circulatory support in patients with trauma.<br />
Cochrane Database Syst Rev:CD001856 [LoE 1a]<br />
35. Dries Dj (1996) Hypotensive resuscitation. Shock<br />
6:311-316 [LoE 5]<br />
36. Dutton Rp, Mackenzie Cf, Scalea Tm (2002)<br />
Hypotensive resuscitation during active<br />
hemorrhage: impact on in-hospital mortality. J<br />
Trauma 52:1141-1146<br />
37. Finfer S, Bellomo R, Boyce N et al. (2004) A<br />
comparison of albumin and saline for fluid<br />
resuscitation in the intensive care unit. N Engl J<br />
Med 350:2247-2256<br />
38. Fischer M, Hossmann Ka (1996) Volume expansion<br />
during cardiopulmonary resuscitation reduces<br />
cerebral no-reflow. Resuscitation 32:227-240 [LoE<br />
5]<br />
39. Gandhi Sd, Weiskopf Rb, Jungheinrich C et al.<br />
(2007) Volume replacement therapy during major<br />
orthopedic surgery using Voluven (hydroxyethyl<br />
starch 130/0.4) or hetastarch. Anesthesiology<br />
106:1120-1127 [LoE 1b]<br />
40. Giesecke Ah, Jr., Grande Cm, Whitten Cw (1990)<br />
Fluid therapy and the resuscitation of traumatic<br />
shock. Crit Care Clin 6:61-72 [LoE 5]<br />
41. Hankeln K, Lenz I, Hauser B (1988) [Hemodynamic<br />
effect of 6% hydroxyethyl starch (HES<br />
200,000/0.62)]. Anaesthesist 37:167-172 [LoE 2b]<br />
42. Hartl R, Medary Mb, Ruge M et al. (1997)<br />
Hypertonic/hyperoncotic saline attenuates<br />
microcirculatory disturbances after traumatic brain<br />
injury. J Trauma 42:S41-47 [LoE 2b]<br />
43. Healey Ma, Davis Re, Liu Fc et al. (1998) Lactated<br />
ringer's is superior to normal saline in a model of<br />
massive hemorrhage and resuscitation. J Trauma<br />
45:894-899 [LoE 5]<br />
44. Holte K, Kristensen Bb, Valentiner L et al. (2007)<br />
Liberal versus restrictive fluid management in knee<br />
arthroplasty: a randomized, double-blind study.<br />
Anesth Analg 105:465-474 [LoE 1b]<br />
45. Hyde J, Graham T (1999) Pre-hospital fluid<br />
resuscitation for thoracic trauma. Pre-hospital<br />
Immediate Care 3:99-101 [LoE 5]<br />
46. Kalbe P, Kant Cj (1988) [First aid at the scene of<br />
the accident from the viewpoint of the trauma<br />
surgeon]. Orthopade 17:2-10 [LoE 5]<br />
47. Kempski O, Obert C, Mainka T et al. (1996) "Small<br />
volume resuscitation" as treatment of cerebral blood<br />
flow disturbances and increased ICP in trauma and<br />
ischemia. Acta Neurochir Suppl 66:114-117 [LoE 5]<br />
48. Krausz Mm, Bashenko Y, Hirsh M (2001)<br />
Crystalloid and colloid resuscitation of uncontrolled<br />
hemorrhagic shock following massive splenic<br />
injury. Shock 16:383-388 [LoE 5]<br />
49. Kreimeier U, Christ F, Frey L et al. (1997) [Smallvolume<br />
resuscitation for hypovolemic shock.<br />
Concept, experimental and clinical results].<br />
Anaesthesist 46:309-328 [LoE 5]<br />
50. Kreimeier U, Messmer K (1992) [Use of hypertonic<br />
NaCl solutions in primary volume therapy].<br />
Zentralbl Chir 117:532-539 [LoE 5]<br />
51. Kreimeier U, Prueckner S, Peter K (2000)<br />
Permissive hypotension. Schweiz Med Wochenschr<br />
130:1516-1524 [LoE 5]<br />
52. Kroll W, Gassmayr Se, Izmail S et al. (1997)<br />
Prehospital fluid resuscitation. Acta Anaesthesiol<br />
Scand Suppl 111:301-302 [LoE 5]<br />
53. Langeron O, Doelberg M, Ang Et et al. (2001)<br />
Voluven, a lower substituted novel hydroxyethyl<br />
starch (HES 130/0.4), causes fewer effects on<br />
coagulation in major orthopedic surgery than HES<br />
200/0.5. Anesth Analg 92:855-862 [LoE 1b]<br />
54. Laxenaire MC, Charpentier C, Feldman L (1994)<br />
Anaphylactoid reactions to colloid plasma<br />
substitutes: incidence, risk factors, mechanisms. A<br />
French multicenter prospective study. Ann Fr<br />
Anesth Reanim. 1994;13(3):301-10 [LoE 1b]<br />
55. Levison M, Trunkey Dd (1982) Initial assessment<br />
and resuscitation. Surg Clin North Am 62:9-16<br />
[LoE 5]<br />
56. Marzi I (1996) [Hemorrhagic shock]. Anaesthesist<br />
45:976-992 [LoE 5]<br />
57. Matsuoka T, Hildreth J, Wisner Dh (1996)<br />
Uncontrolled hemorrhage from parenchymal injury:<br />
is resuscitation helpful? J Trauma 40:915-921;<br />
discussion 921-912 [LoE 5]<br />
58. Matsuoka T, Wisner Dh (1996) Resuscitation of<br />
uncontrolled liver hemorrhage: effects on bleeding,<br />
oxygen delivery, and oxygen consumption. J<br />
Trauma 41:439-445<br />
59. Mattox Kl, Maningas Pa, Moore Ee et al. (1991)<br />
Prehospital hypertonic saline/dextran infusion for<br />
post-traumatic hypotension. The U.S.A. Multicenter<br />
Trial. Ann Surg 213:482-491 [LoE 1b]<br />
Prehospital – Volume replacement 48
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
60. Nolan J (1999) Fluid replacement. Br Med Bull<br />
55:821-843 [LoE 5]<br />
61. Pargger H, Studer W, Ruttimann U (2000) [Volume<br />
therapy in hypotensive trauma patients]. Schweiz<br />
Med Wochenschr 130:1509-1515 [LoE 5]<br />
62. Pitts R, Lotspeich W (1946) Bicarbonate and the<br />
renal regulation of acid base balance. Am J Physiol<br />
147:138-157<br />
63. Pitts Rf, Ayer Jl, Schiess Wa (1949) The renal<br />
regulation of acid-base balance in man; the<br />
reabsorption and excretion of bicarbonate. J Clin<br />
Invest 28:35-44<br />
64. Raum M, Holzgraefe B, Rixen D et al. (2000) Der<br />
Einfluß von exogenem Laktat auf gemessene<br />
Plasmalaktatspiegel im hämorrhagischen Schock-<br />
eine kontrollierte Studie am Schwein. Chir. Forum<br />
Band 29:543-547<br />
65. Raum M, Rixen D, Linker R et al. (2002) [Influence<br />
of lactate infusion solutions on the plasma lactate<br />
concentration]. Anasthesiol Intensivmed Notfallmed<br />
Schmerzther 37:356-358 [LoE 5]<br />
66. Rhee P, Burris D, Kaufmann C et al. (1998)<br />
Lactated Ringer's solution resuscitation causes<br />
neutrophil activation after hemorrhagic shock. J<br />
Trauma 44:313-319 [LoE 5]<br />
67. Riddez L, Johnson L, Hahn Rg (1998) Central and<br />
regional hemodynamics during crystalloid fluid<br />
therapy after uncontrolled intra-abdominal bleeding.<br />
J Trauma 44:433-439 [LoE 5]<br />
68. Ring J, Messmer K (1977) Incidence and severity of<br />
anaphylactoid reactions to colloid volume<br />
substitutes. Lancet 1:466-469<br />
69. Roberts K, Revell M, Youssef H et al. (2006)<br />
Hypotensive resuscitation in patients with ruptured<br />
abdominal aortic aneurysm. Eur J Vasc Endovasc<br />
Surg 31:339-344 [LoE 1a]<br />
70. Rocha E Silva M, Velasco It (1989) Hypertonic<br />
saline resuscitation: the neural component. Prog<br />
Clin Biol Res 299:303-310 [LoE 5]<br />
71. Rossi R (1997) [Early care or quick transport? The<br />
effectiveness of preclinical treatment of emergency<br />
patients]. Anaesthesist 46:126-132 [LoE 5]<br />
72. Sackett Dl, Richardson Ws, Rosenberg W et al.<br />
(1997) Evidence-based medicine: How to practice<br />
and teach EBM. Churchill Livingstone, London<br />
73. Sampalis Js, Tamim H, Denis R et al. (1997)<br />
Ineffectiveness of on-site intravenous lines: is<br />
prehospital time the culprit? J Trauma 43:608-615;<br />
discussion 615-607<br />
74. Schmand Jf, Ayala A, Morrison Mh et al. (1995)<br />
Effects of hydroxyethyl starch after traumahemorrhagic<br />
shock: restoration of macrophage<br />
integrity and prevention of increased circulating<br />
interleukin-6 levels. Crit Care Med 23:806-814<br />
[LoE 5]<br />
75. Schwarz S, Schwab S, Bertram M et al. (1998)<br />
Effects of hypertonic saline hydroxyethyl starch<br />
solution and mannitol in patients with increased<br />
intracranial pressure after stroke. Stroke 29:1550-<br />
1555 [LoE 2b]<br />
76. Shackford Sr (1997) Effect of small-volume<br />
resuscitation on intracranial pressure and related<br />
cerebral variables. J Trauma 42:S48-53 [LoE 5]<br />
77. Shah N, Palmer C, Sharma P (1998) Outcome of<br />
raising blood pressure in patients with penetrating<br />
trunk wounds. Lancet 351:648-649 [LoE 5]<br />
78. Shires Gt (1977) Pathophysiology and fluid<br />
replacement in hypovolemic shock. Ann Clin Res<br />
9:144-150 [LoE 5]<br />
79. Singbartl G (1985) [Significance of preclinical<br />
emergency treatment for the prognosis of patients<br />
with severe craniocerebral trauma]. Anasth<br />
Intensivther Notfallmed 20:251-260 [LoE 2a]<br />
80. Taylor Dc, Salvian Aj, Shackleton Cr (1988) Crush<br />
syndrome complicating pneumatic antishock<br />
garment (PASG) use. Injury 19:43-44 [LoE 3a]<br />
81. Tokyay R, Zeigler St, Kramer Gc et al. (1992)<br />
Effects of hypertonic saline dextran resuscitation on<br />
oxygen delivery, oxygen consumption, and lipid<br />
peroxidation after burn injury. J Trauma 32:704-<br />
712; discussion 712-703 [LoE 5]<br />
82. Trunkey Dd (2001) Prehospital fluid resuscitation of<br />
the trauma patient. An analysis and review. Emerg<br />
Med Serv 30:93-95, 96, 98 passim [LoE 5]<br />
83. Turner J, Nicholl J, Webber L et al. (2000) A<br />
randomised controlled trial of prehospital<br />
intravenous fluid replacement therapy in serious<br />
trauma. Health Technol Assess 4:1-57 [LoE 1b]<br />
84. Vassar Mj, Perry Ca, Holcroft Jw (1993) Prehospital<br />
resuscitation of hypotensive trauma patients with<br />
7.5% NaCl versus 7.5% NaCl with added dextran: a<br />
controlled trial. J Trauma 34:622-632; discussion<br />
632-623 [LoE 1b]<br />
85. Velanovich V (1989) Crystalloid versus colloid<br />
fluid resuscitation: a meta-analysis of mortality.<br />
Surgery 105:65-71 [LoE 1b]<br />
86. Velasco It, Pontieri V, Rocha E Silva M, Jr. et al.<br />
(1980) Hyperosmotic NaCl and severe hemorrhagic<br />
shock. Am J Physiol 239:H664-673 [LoE 5]<br />
87. Velasco It, Rocha E Silva M, Oliveira Ma et al.<br />
(1989) Hypertonic and hyperoncotic resuscitation<br />
from severe hemorrhagic shock in dogs: a<br />
comparative study. Crit Care Med 17:261-264 [LoE<br />
5]<br />
88. Wade Ce, Dubick Ma, Grady Jj (2003) Optimal<br />
dose of hypertonic saline/dextran in hemorrhaged<br />
swine. J Trauma 55:413-416 [LoE 5]<br />
89. Wade Ce, Grady Jj, Kramer Gc (2003) Efficacy of<br />
hypertonic saline dextran fluid resuscitation for<br />
patients with hypotension from penetrating trauma.<br />
J Trauma 54:S144-148 [LoE 1b]<br />
90. Wade Ce, Kramer Gc, Grady Jj et al. (1997)<br />
Efficacy of hypertonic 7.5% saline and 6% dextran-<br />
70 in treating trauma: a meta-analysis of controlled<br />
clinical studies. Surgery 122:609-616 [LoE 1a]<br />
91. Waschke Kf, Albrecht Dm, Van Ackern K et al.<br />
(1996) Coupling between local cerebral blood flow<br />
and metabolism after hypertonic/hyperoncotic fluid<br />
resuscitation from hemorrhage in conscious rats.<br />
Anesth Analg 82:52-60 [LoE 5]<br />
Prehospital – Volume replacement 49
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
92. Waschke Kf, Frietsch T (1999) Selection of<br />
adequate substitutes for intravascular volume<br />
replacement. Int J Intens Care 2:135-143 [LoE 5]<br />
93. Weinstabl C, Hammerle A (1992) Hypertone,<br />
hyperonkotische Hydroxyäthylstärke-Lösung zur<br />
Senkung des intrakraniellen Druckes. Fortschr<br />
Anaesth 6:105-107 [LoE 2b]<br />
94. Yaghoubian A, Lewis Rj, Putnam B et al. (2007)<br />
Reanalysis of prehospital intravenous fluid<br />
administration in patients with penetrating truncal<br />
injury and field hypotension. Am Surg 73:1027-<br />
1030 [LoE 2a]<br />
Prehospital – Volume replacement 50
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.4 Thorax<br />
Diagnostic tests<br />
The decision whether to carry out drainage or decompression of the pleural space is based on<br />
examination, assessment of findings (diagnosis), and benefit-risk evaluation (diagnosis certainty<br />
with limited diagnostic options, time factor, concomitant circumstances, and risks attached to the<br />
method itself).<br />
Examination<br />
Key recommendation:<br />
A clinical examination of the thorax and respiratory function must be carried<br />
out.<br />
The examination should include as a minimum the measurement of the<br />
respiratory rate and auscultation of the lungs. The examination should be<br />
repeated.<br />
The following can be helpful: inspection (bilaterally unequal in respiratory<br />
excursion, unilateral bulging, paradoxical respiration), palpation (pain,<br />
crepitations, subcutaneous emphysema, instability) and percussion (hyperresonant<br />
percussion) of the thorax together with pulse oxymetry and, in<br />
ventilated patients, monitoring ventilation pressure.<br />
Explanation:<br />
Initial examination<br />
GoR A<br />
GoR B<br />
GoR 0<br />
The physical examination of the patient is required for establishing a diagnosis, which in turn is a<br />
prerequisite for treatment interventions. An acute life-threatening disorder can only be<br />
recognized by examination. Even without scientific proof, it appears to be absolutely essential<br />
[89].<br />
Scientific studies on the type and scope of physical examination are mainly only on auscultation,<br />
measuring respiratory rate and on clarifying spontaneous pain and tenderness. Thus, only<br />
experience can define the required scope of the physical examination in the prehospital<br />
emergency examination.<br />
In the emergency situation at the accident scene, the initial examination of the thorax should<br />
include (after checking and securing the vital functions) checking the respiratory rate and<br />
auscultation (presence of breath sounds, bilaterally equal breath sounds) [14, 36, 39, 40]. All<br />
these signs are correlated to significant pathologies or have a direct influence on medical<br />
decisions. Other useful examinations can be inspection (for signs of injury, symmetry of the<br />
Prehospital – Volume replacement 51
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
thorax, symmetry of respiratory excursion, paradoxical respiration, dyspnea, distended neck<br />
veins) and palpation (subcutaneous emphysema, pain points, crepitations, instabilities in the<br />
bony structure of the thorax). Monitoring ventilation pressure and pulse oxymetry can be added<br />
in the course of further management [55].<br />
All the above-mentioned examinations are used to detect relevant, threatening or potentially<br />
threatening disorders and injuries, which altogether can make it necessary to administer<br />
immediate and specific treatment or make a logistical decision on the spot. All diagnostic<br />
procedures that can be introduced prehospital are without specific risk, the only disadvantage<br />
being the loss of time, which is usually minimal.<br />
The different findings are to some extent greatly dependent on the examiner, the patient and the<br />
environment. For instance, noise can make auscultation more difficult or impossible. Such<br />
circumstances must be taken into account when selecting and interpreting the primary diagnostic<br />
study [36, 40, 80, 135].<br />
Several researchers showed that, under in-hospital conditions, ultrasound examination (lung<br />
sliding, lung point, comet tail, etc.) allows good and accurate detection of pneumothorax and<br />
hemothorax (review in [87]). However, there is no experience in prehospital application so a<br />
general recommendation cannot be made.<br />
Patient monitoring<br />
The respiratory rate and, if applicable, ventilation pressure should be checked and auscultation<br />
and pulse oxymetry performed during the course since a disorder in the respiratory system, a<br />
misplacement of the tube, tension pneumothorax or acute respiratory insufficiency can develop<br />
dynamically. The follow-up examination can serve as a performance check of the treatment<br />
administered.<br />
Prehospital – Volume replacement 52
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Diagnosing pneumothorax<br />
Key recommendations:<br />
A suspected diagnosis of pneumothorax and/or hemothorax must be made if<br />
breath sounds are weaker or absent on one side (after checking correct<br />
placement of the tube). Absence of such auscultation findings largely rules<br />
out a larger pneumothorax, especially if the patient is normopneic and has no<br />
chest pain.<br />
The potential progression of a small pneumothorax which cannot initially be<br />
diagnosed in the prehospital phase should be taken into consideration.<br />
Explanation:<br />
GoR A<br />
GoR B<br />
There are currently no methods available for definite prehospital detection or exclusion of<br />
pneumothorax. This is only clinically possible by computed tomography (exclusion).<br />
Auscultation<br />
The studies on diagnostic accuracy of auscultation are summarized in<br />
Table 4. The specificity of a unilateral weakened or absent breath sound for the presence of<br />
pneumothorax is very high at 93-98%. The positive predictive value, i.e. the probability of there<br />
actually being a pneumothorax in the presence of a weakened breath sound, is also very high at<br />
86-97% [35, 135]. Pneumothoraces not detected by auscultation had a mean volume of 378 ml<br />
(max. 800 ml), non-detected hemothoraces had a mean volume of 277 ml (max. 600 ml). No<br />
large, acutely threatening lesions were missed [36, 80]. In another prospective series,<br />
auscultation was the most reliable method of detecting a pneumohemothorax compared to<br />
evidence of pain or tachypnea [24]. Conversely, a hemo-/pneumothorax was virtually excluded<br />
in the presence of normopnea and normal auscultation and palpation findings [24].<br />
The prerequisite is the correct placement of the endotracheal tube (as available), which must be<br />
ensured beforehand if possible. A proviso must be given here that the cited studies were not<br />
conducted at the emergency site but on emergency admission in the hospital. However, they<br />
appear to be easily transferable as numerous confounders (e.g., high noise level, disturbance) can<br />
also predominate in a comparable manner in emergency admission. False positive findings can<br />
occasionally be present (4.5% of cases in [88]) in tube misplacements, diaphragmatic rupture [1,<br />
4] or ventilation disorders (large atelectases, shifting of deeper respiratory tracts).<br />
If there are severe bilateral chest injuries, the presence of a bilateral pneumothorax should be<br />
considered. Atypical examination findings may occur in this case.<br />
Data for differentiating between a pneumothorax and a hemothorax or mixed types are<br />
unavailable. Percussion can be helpful here but in the prehospital setting seems to be only of<br />
Prehospital – Volume replacement 53
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
subordinate relevance as the differentiation between pneumo- and hemothorax has no provable<br />
effects on treatment requirements (see below).<br />
Table 4: Diagnostic valency of a pathologic auscultation finding with regard to a<br />
hemo/pneumothorax<br />
Study LoE Patient collective Sensitivity Specificity<br />
Hirshberg et al. 1988 [80] 1 Sharp trauma (n = 51) 96% 93%<br />
Wormland et al. 1989<br />
[143]<br />
3 Sharp trauma (n = 200) 73.3% 98.6%<br />
Thomson et al. 1990 [135] 1 Sharp trauma (n = 102) 96% 94%<br />
Chen et al. 1997 [36] 3 Sharp trauma (n = 118) 58% 98%<br />
Chen et al. 1998 [35] 1<br />
Mainly blunt trauma<br />
(n = 148)<br />
84% 97%<br />
Bokhari et al. 2002 [24] 2 Blunt trauma (n = 523) 100% 99.8%<br />
Bokhari et al. 2002 [24] 2 Sharp trauma (n = 153) 50% 100%<br />
Dyspnea<br />
Even if the symptoms of dyspnea and tachypnea are difficult to quantify in consciousnessclouded<br />
patients, evidence of normopnea (respiratory rate between 10-20/min) can be put to<br />
good use in clinical practice. Several studies revealed that normopnea is a very reliable sign that<br />
a larger hemo/pneumothorax can be excluded after blunt trauma (high specificity). In contrast,<br />
the presence of dyspnea in no way indicates the reverse, that pneumothorax is present (low<br />
sensitivity).<br />
Table 5: Diagnostic valency of dyspnea and tachypnea with regard to hemo/pneumothorax<br />
Study LoE Patient collective Sensitivity Specificity<br />
Wormland et al. 1989 [143] 3 Sharp trauma (n = 200 patients) 75.6% 84.1%<br />
Hing et al. 2001 [79] 4 Sharp trauma (n = 153 patients) 72.7% 95.5%<br />
Bokhari et al. 2002 [24] 2 Blunt trauma (n = 523 patients) 42.8% 99.6%<br />
Bokhari et al. 2002 [24] 2 Sharp trauma (n = 153 patients) 31.8% 99.2%<br />
Prehospital – Volume replacement 54
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Thoracic pain and pneumothorax<br />
Fully conscious patients can be asked if they have chest pains. In addition, the clinical<br />
examination provides indications of tenderness in the thoracic region. There is only one clinical<br />
study that ranks absence of pain, and it reveals good specificity particularly for sharp trauma<br />
[24]. On the other hand, this finding only has adequate diagnostic accuracy in the overall picture<br />
with other findings.<br />
Table 6: Diagnostic valency of thoracic pain with regard to hemo/pneumothorax<br />
Study LoE Patient collective Sensitivity Specificity<br />
Bokhari et al., 2002 [24] 2 Blunt trauma (n = 523 patients) 57.1% 78.6%<br />
Bokhari et al., 2002 [24] 2 Sharp trauma (n = 153 patients) 25.0% 91.5%<br />
Synopsis of thoracic pain, dyspnea, auscultation<br />
Table 7 presents the diagnostic accuracy for the presence of pneumothorax after blunt trauma in<br />
relation to the presence of thoracic pain, dyspnea, and unilateral weakened breath sounds<br />
detected by auscultation.<br />
Table 7: Statistical probabilities for the presence of a clinically relevant hemopneumothorax in<br />
various combinations of findings after blunt chest injury (basic assumption: 10% prevalence as<br />
pretest probability and independence of test)<br />
Thoracic pain<br />
(sensitivity 57%,<br />
specificity 79%)<br />
Dyspnea<br />
(sensitivity 43%,<br />
specificity 98%)<br />
Auscultation<br />
(sensitivity 90%,<br />
specificity 98%)<br />
Probability for hemo/<br />
pneumothorax<br />
+ + + > 99%<br />
+ + - 40%<br />
+ - + 89%<br />
+ - - 2%<br />
- + + 98%<br />
- + - 12%<br />
- - + 61%<br />
- - - < 1%<br />
Chest injury and pneumothorax<br />
If a chest injury is present, it is not unusual to conclude an increased risk of pneumothorax being<br />
present and from this the indication for pleural drainage. Two issues must be considered here:<br />
Prehospital – Volume replacement 55
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
the success rate of emergency physicians for diagnosing chest injury and the correlation between<br />
a chest injury and a concomitant pneumothorax.<br />
However, the diagnostic accuracy of the emergency physician is greatly limited. An analysis of<br />
data from the <strong>DGU</strong> Trauma Registry showed that the emergency physician had grossly<br />
overestimated the chest injury in 18% of cases, i.e. the emergency physician assumed a severe<br />
chest injury which was not actually there [7].<br />
In 9-50% of patients with confirmed chest injury, there was also a pneumothorax. It should be<br />
noted with these figures that the diagnosis of chest injury in all these studies had been made after<br />
a full set of diagnostic tests including imaging.<br />
In the majority of studies, between 37 and 59% of patients with a relevant chest injury diagnosed<br />
in hospital had a pneumothorax [23, 55, 66, 137]. If occult pneumothoraces - in other words,<br />
those which can only be detected in CT but not clinically and not in standard radiography - are<br />
not included, then the proportion of patients with chest injury who have a relevant pneumothorax<br />
is actually only 17-25% [23, 137]. However, the incidence of pneumothorax secondary to chest<br />
injury was markedly lower at 8.9% in individual studies [52].<br />
Table 8: Incidence of pneumothorax in the presence of chest injury<br />
Study Incidence of pneumothorax (radiologic diagnostic test without CT)<br />
Blostein et al. 1997 [23] 25% of chest injuries<br />
Demartines et al. 1990 [52] 8.9% of chest injuries<br />
Di Bartolomeo et al. 2001 [55] 21% of all critically injured<br />
Gaillard et al. 1990 [66] 41% of chest injuries<br />
Trupka et al. 1997 [137] 17% of chest injuries<br />
Other examinations and pneumothorax<br />
Evidence of subcutaneous emphysema is viewed as an indication of the presence of<br />
pneumothorax. However, there are no good diagnostic studies to support this. The specificity and<br />
positive predictive value are not known. However, the sensitivity is low and is between 12 and<br />
25% [47, 126]. In a 30-year old study, it was reported that subcutaneous emphysema in intensive<br />
care patients had 100% sensitivity for the presence of tension pneumothorax. However, these<br />
data are possibly not transferable to acutely ill trauma patients in the prehospital phase [130].<br />
Taking into account the relatively high rate of false findings, the findings of an unstable thorax<br />
and of crepitations are indications of the presence of a chest injury but not of pneumothorax.<br />
Prehospital – Volume replacement 56
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Pneumothorax and progression<br />
The potential progression of an initially asymptomatic pneumothorax is important, particularly in<br />
air rescue as well. The progression of pneumothoraces can vary considerably among individuals,<br />
and basically the full range from in-hospital finding to rapid progression is possible. The<br />
observation of small pneumothoraces can provide certain clues. In a small retrospective series,<br />
13 patients with occult pneumothorax were conservatively treated, 6 of whom were being<br />
mechanically ventilated. It was subsequently necessary in 2 cases to insert a chest drain due to a<br />
progressive pneumothorax on the second and third day, respectively, after admission [38]. In a<br />
prospective randomized study, 8 out of 21 patients with an occult pneumothorax which was<br />
under observation developed progressive pneumothorax and, in 3 cases, tension pneumothorax.<br />
All these patients were ventilated [60]. The 3 tension pneumothoraces occurred in the operating<br />
room, post-operative after admission to the intensive care unit, and during a prolonged<br />
stabilization phase; exact times in hours after trauma are not available. A period of at least 30-<br />
60 minutes after hospital admission can at least be assumed. In another prospective randomized<br />
study of the treatment of occult pneumothoraces, the progression of pneumothorax in the group<br />
of conservatively treated patients (12.5%) was not greater than those on a pleural drain (21%)<br />
[25]. Details concerning the duration of pneumothorax progression were not recorded. In a series<br />
of 44 newborn, mostly intubated children, the time between the probable start of pneumothorax<br />
and the clinical diagnosis being made was on average 127 minutes with a scatter between 45 and<br />
660 minutes [99].<br />
In 3 studies, the maximum size of pneumothorax was indicated as 5 x 80 ml (400 ml), beyond<br />
which pleural drainage was indicated [25, 60, 70]. However, as pneumothoraces of this size can<br />
usually already be clinically diagnosed by auscultation (see above), it can be assumed that the<br />
progression of pneumothoraces with normal auscultation finding meets the above-mentioned<br />
conditions.<br />
Most experts believe that the progression of pneumothorax to tension pneumothorax is greater in<br />
patients who are on positive pressure ventilation [13] but this cannot be quantified.<br />
To summarize, the data suggest that small, clinically non-diagnosable pneumothoraces generally<br />
progress relatively slowly and thus do not require any emergency decompression in the<br />
prehospital phase.<br />
Prehospital – Volume replacement 57
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Diagnosing tension pneumothorax<br />
Key recommendation:<br />
A suspected diagnosis of tension pneumothorax should be made if<br />
auscultation of the lung reveals no breath sounds unilaterally (after checking<br />
correct placement of the tube) and, in addition, typical symptoms are<br />
present, particularly severe respiratory disorder or upper inflow congestion<br />
combined with arterial hypotension.<br />
Explanation:<br />
GoR B<br />
Good scientific data on diagnostic accuracy of examination findings for tension pneumothorax<br />
are few and far between. Practically all conclusions are based on case reports, animal<br />
experiments or expert opinion. There is no uniform definition on exactly what tension<br />
pneumothorax means. The definitions range from pneumothorax with threatening disorders to<br />
vital functions, hiss of escaping air during needle decompression, mediastinal shift on the chest<br />
X-ray, raised ipsilateral intrapleural pressure, and hemodynamic compromise [91]. For obvious<br />
reasons, the ad-hoc diagnosis in the prehospital phase can only be made on the basis of clinical<br />
examination findings.<br />
The vast majority of experts consider the diagnosis of tension pneumothorax as given if lifethreatening<br />
hemodynamic or respiratory disorders are present. Cyanosis, breathlessness,<br />
tachypnea, contralateral tracheal deviation, and a drop in oxygen saturation, elevated respiratory<br />
excursion and bulging hemithorax with hyper-resonant percussion on the diseased side are<br />
possible respiratory signs. Hemodynamic indicators can include distended neck veins,<br />
tachycardia, and ultimately a drop in blood pressure through to cardiac arrest (pulseless electrical<br />
activity). However, many of these signs can only be detected on closer examination and have not<br />
been systematically examined to date. There are few data on trauma patients; most information<br />
has been gained from observing tension pneumothoraces in intensive care medicine [90].<br />
Experimental examinations show that, in the alert patient, respiratory impairment and paralysis<br />
of the respiratory center secondary to hypoxia precede cardiac arrest, and hypotension, the<br />
endpoint of which is cardiac arrest, is a late sign of tension pneumothorax [13, 124]. These<br />
experimental findings were recently confirmed by a patient with accidental tension<br />
pneumothorax, who became dyspneic, cyanotic and <strong>final</strong>ly unconscious before respiratory arrest<br />
occurred. However, the carotid pulse could be felt throughout [131]. The patient’s condition<br />
normalized rapidly after decompressing the elevated intrapleural pressure. A tension<br />
pneumothorax in the radiograph (mediastinal shift to the contralateral side) without signs of<br />
impaired circulation has been described in another case report [101]. This patient’s circulation<br />
remained stable in the 30-minute period between making the diagnosis and inserting the chest<br />
drain. In another case report, the tension pneumothorax manifested itself clinically by cyanosis,<br />
an increase in respiratory and heart rate and impaired consciousness (GCS 10) while other signs<br />
were absent. However, a careful inspection revealed ipsilateral overextension and hypomobility<br />
in the chest wall. In a review article from 2005, the two symptoms, breathlessness and<br />
Prehospital – Volume replacement 58
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
tachycardia, were presented as the typical and most frequent signs of tension pneumothorax in<br />
the alert patient [91].<br />
However, the same authors also showed that in ventilated patients the cardio-circulatory<br />
symptoms of tension pneumothorax occurred earlier and the respiratory symptoms and fall in<br />
blood pressure often manifested themselves simultaneously. In the ventilated patient, very<br />
elevated or rising airway pressures are an important additional symptom that can be found in<br />
approximately 20% of patients with hemo/pneumothorax [14, 40]. However, systematically<br />
collected data concerning diagnostic accuracy are not available. According to expert opinion, the<br />
combination of (unilaterally) absent breath sound (with tube placement monitored) and lifethreatening<br />
respiratory and circulatory function disorders makes the presence of tension<br />
pneumothorax so probable that the diagnosis should be made and the necessary therapeutic<br />
consequences followed. The consequences of a false diagnosis of tension pneumothorax appear<br />
to be subordinate compared to failing to carry out necessary decompression.<br />
Indications for pleural decompression<br />
Key recommendations:<br />
Clinically suspected tension pneumothorax must be decompressed<br />
immediately.<br />
Pneumothorax diagnosed on the basis of an auscultation finding in a patient<br />
on positive pressure ventilation should be decompressed.<br />
Pneumothorax diagnosed on the basis of an auscultation finding in patients<br />
not on ventilation should usually be managed by close clinical observation.<br />
Explanation:<br />
GoR A<br />
GoR B<br />
GoR B<br />
Comparative studies between conservative and interventional treatment are not available. The<br />
treatment recommendations are based on expert opinion and consideration of the probabilities.<br />
Tension pneumothorax<br />
Tension pneumothorax is an acute life-threatening situation and, if untreated, generally leads to<br />
death. Death can occur within a few minutes of the onset of signs of restricted pulmonary and<br />
circulatory function. There is no alternative to decompression. The experts are of the opinion that<br />
immediate emergency decompression should be carried out particularly on onset of circulatory<br />
or respiratory impairment and that the time lost through transferring the patient to a hospital,<br />
even one situated in the immediate vicinity, represents an unjustifiable delay. In a study of 3,500<br />
autopsies, there were 39 cases of tension pneumothorax (incidence 1.1%), half of whom had not<br />
been diagnosed while still alive. Among soldiers from the Vietnam war, 3.9% of all patients with<br />
chest injuries and 33% of all soldiers with fatal chest injury had tension pneumothorax [100]. An<br />
analysis of 20 patients who had been categorized as unexpected survivors based on the TRISS<br />
Prehospital – Volume replacement 59
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
prognosis showed that tension pneumothorax had been treated by decompression in 7 of them in<br />
the prehospital phase [29].<br />
Diagnosed pneumothorax<br />
A large pneumothorax, which can be assumed if a typical auscultation finding is collected,<br />
essentially presents an indication to evacuate the pleural cavity. Whether this has to take place in<br />
the prehospital phase or once admitted to hospital is difficult to decide in the individual case as<br />
the risk of progression from simple pneumothorax to tension pneumothorax and the amount of<br />
time that such a development can take are variable and difficult to estimate. The literature<br />
contains neither general data nor risk factors on this topic. There are indications that intubated<br />
patients with a chest injury when admitted to hospital are more likely to have tension<br />
pneumothorax than non-intubated patients. Overall, it still appears plausible to the experts that a<br />
pneumothorax diagnosed by auscultation in a ventilated patient has a markedly higher risk of<br />
developing into tension pneumothorax; thus, prehospital decompression is indicated.<br />
If a patient with pneumothorax diagnosed by auscultation is not ventilated, then the risk of<br />
progression to tension pneumothorax appears to be markedly lower. In a series of 54<br />
pneumothoraces after trauma, 29 were treated conservatively, i.e. without inserting a pleural<br />
drain. These were non-ventilated patients, mostly without concomitant injuries. A pleural drain<br />
was inserted in only 2 cases 6 hours after admission to hospital because of radiologic progressive<br />
pneumothorax [85]. Prehospital decompression does not appear to be necessary here and close<br />
clinical observation should be carried out. If appropriate clinical monitoring is an issue, e.g.,<br />
during helicopter transfer, then there is a certain, unquantifiable risk that tension pneumothorax<br />
will develop which will not be recognized in time and/or which cannot be adequately treated due<br />
to space limitations. In such situations, if relevant clinical signs are present and after individual<br />
assessment, decompression of the pneumothorax can be carried out before transfer even in nonintubated<br />
patients.<br />
Chest injury without direct pneumothorax diagnosis<br />
If no pneumothorax is diagnosed (i.e. if the auscultation finding shows no lateral difference),<br />
then there is also essentially no indication for prehospital decompression or pleural evacuation.<br />
The presence of clear signs of severe chest injury means that between 10 and 50% of these<br />
patients may have a pneumothorax (see above) and thus pleural drainage could be indicated in<br />
every second to tenth patient. Conversely, this means that at least every second patient and up to<br />
9 out of every 10 patients would, under these conditions, receive unnecessary invasive treatment.<br />
This also coincides with the findings that air released from the pleural space was observed in<br />
only 32-50% of cases of prehospital decompression [14, 125], and decompression was not<br />
indicated in 9-25% of cases of pleural drains inserted in the prehospital phase as there was no<br />
pneumothorax or chest injury [7, 8, 125].<br />
In addition, it should be considered that the radiologic findings have not been correlated to the<br />
clinical findings in the studies on pneumothorax incidence in chest injury. It can be assumed that<br />
numerous radiologically detectable pneumothoraces could also have been diagnosed by<br />
auscultation. The rate of pneumothoraces which cannot be diagnosed clinically but are present in<br />
Prehospital – Volume replacement 60
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
chest injury can thus be assumed to be much lower [38]. As occult pneumothoraces were also<br />
included in a series of these studies, i.e. pneumothoraces which were first detectable at least 30<br />
minutes after hospital admission only by computed tomography but not by standard radiography<br />
[23, 137], the proportion of prehospital relevant pneumothoraces falls even further. The risk of a<br />
pneumothorax, which at the time of primary survey was small and yielded a normal auscultation<br />
finding, progressing to tension pneumothorax has already been discussed above and should be<br />
viewed as minor in the prehospital timeframe.<br />
Thus, in a justified individual case, decompression can be carried out in ventilated patients with<br />
clear signs of chest injury but normal auscultation finding prior to long road or helicopter<br />
transfer with limited clinical monitoring or treatment options. The high rate of false positive<br />
diagnoses of chest injury by the emergency physician must be taken into consideration.<br />
Under these conditions, decompression is not indicated in non-ventilated patients.<br />
Other indications<br />
Pneumothorax and hemothorax represent the only typical indications for pleural decompression<br />
or pleural drainage in prehospital acute medicine. The therapeutic management of pneumothorax<br />
has already been presented above. Although hemothorax is essentially an indication for<br />
evacuating the blood located in the pleural space, there is generally no direct danger of<br />
compression from the blood and there is no indication for evacuation of the blood to the outside<br />
in the prehospital phase. Emergency decompression can only be indicated in cases of massive<br />
bleeding, possibly with problems developing in terms of tension hemothorax. However, this<br />
situation is generally associated with a pathologic auscultation finding and will thus make it<br />
necessary to proceed as per the situation with a pneumothorax, especially as it is generally<br />
always difficult to differentiate between a hemothorax and a hemopneumothorax in the<br />
prehospital phase.<br />
Treatment<br />
Methods<br />
The aim of the treatment is decompression of positive pressure in tension pneumothorax or<br />
tension hemothorax. The second treatment goal to be considered is the prevention of a simple<br />
pneumothorax developing into a tension pneumothorax. The permanent and, if possible,<br />
complete evacuation of air and blood is of no importance in the prehospital emergency.<br />
Key recommendations:<br />
Tension pneumothorax should be decompressed by needle<br />
decompression, followed by surgery to open the pleural space with or without<br />
a chest drain.<br />
GoR B<br />
Prehospital – Volume replacement 61
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Pneumothorax should be treated with a chest drain provided the indication<br />
exists.<br />
Explanation:<br />
GoR B<br />
As there are no suitable comparative data on the 3 methods, no recommendation for a method of<br />
choice can be made based on the data. (Predominantly retrospective) data, case series and case<br />
histories are available for all 3 methods and they demonstrate that successful decompression of<br />
tension pneumothorax is possible by each of these methods.<br />
In view of the low evidence level on choice of method and benefit-risk profile in the direct<br />
comparison of methods, the individual ability of the treating emergency physician should be<br />
considered for reasons of practicability and risk potential. In one study, a significant difference<br />
in complication rate for insertion of a chest drain was observed between emergency admission<br />
physicians and surgeons [62]. In a more recent study, a lower complication rate associated with<br />
insertion by surgical compared to non-surgical residents was also observed in North America<br />
[11]. Due to a lack of reliable data, the extent to which these results are transferable to the<br />
German emergency physician system cannot be evaluated.<br />
Chest drain: Efficacy and complications<br />
Insertion of a chest drain is a highly effective, suitable but not complication-free procedure for<br />
decompressing a tension pneumothorax, which must be used particularly when the alternative<br />
interventions have failed or are insufficiently effective. Generally, it also represents the<br />
definitive treatment and has the highest success rate. In 79-95% of cases, pleural drains inserted<br />
in the prehospital phase were the successful, definitive treatment intervention [10, 52, 117, 125].<br />
On the other hand, pleural drainage has a failure rate of 5.4-21% (mean of 11.2%) due to<br />
misplacements or insufficient efficacy. With this frequency, it was necessary to insert an<br />
additional pleural drain [10, 34, 45, 52, 62, 75, 117, 125]. This involved retained<br />
pneumothoraces and hemothoraces to more or less the same extent. Individual cases of persistent<br />
tension pneumothoraces were also observed with pleural drains inserted in the prehospital phase<br />
[10, 31, 98].<br />
The pooled complication rates for pleural drainage are shown in<br />
Prehospital – Volume replacement 62
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 9 and in Table 10 (see appendix). There do not appear to be any relevant differences<br />
between pleural drains inserted in the prehospital and in-hospital phases. However, there are only<br />
2 studies in which the complication rates for prehospital and in-hospital treatment were directly<br />
compared within the same establishment [128, 144]. They revealed comparable infection rates<br />
(9.4 versus 11.7%) and misplacements (0 versus 1.2%). The number of days in situ was<br />
comparable in both groups in each study.<br />
Prehospital – Volume replacement 63
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 9: Complication rates for pleural drains inserted in the prehospital versus in-hospital phase<br />
Complication Only prehospital pleural drains * Only in-hospital pleural drains *<br />
Subcutaneous<br />
misplacements<br />
Intra-pulmonary<br />
misplacements<br />
Intraabdominal<br />
misplacements<br />
Infections (pleural<br />
empyema)<br />
2.53% (1.55–3.33%)<br />
n = 730, 9 studies<br />
[10, 14, 47, 52, 88, 117, 125, 126,<br />
144]<br />
1.37% (0.63–2.58%)<br />
n = 657, 7 studies<br />
[10, 14, 47, 52, 88, 125, 126]<br />
0.87% (0.32–1.88%)<br />
n = 690, 8 studies<br />
[10, 14, 47, 52, 88, 117, 125, 126]<br />
0.55% (0.11–1.59%)<br />
n = 550, 5 studies<br />
[10, 14, 52, 125, 144]<br />
0.39% (0.08–1.13%)<br />
n = 772, 6 studies<br />
[9, 19, 45, 46, 77, 144]<br />
0.63% (0.27-1.23%)<br />
n = 1,275, 7 studies<br />
[9, 19, 45, 46, 54, 77, 107]<br />
0.73% (0.29-1.50%)<br />
n = 956, 5 studies<br />
[9, 45, 46, 77, 107]<br />
1.74% (1.47-2.05%)<br />
n = 8,102, 13 studies<br />
* Mean values obtained from simply adding together the complications given in studies<br />
(confidence interval in brackets)<br />
[9, 19, 34, 46, 54, 62, 107, 144] [59,<br />
76, 77, 94, 129]<br />
The case histories for the puncture site of the anterior to midaxillary line also report on injury to<br />
the intercostal arteries [32], lung perforations [65], perforations of the right atrium [33, 104,<br />
127], the right ventricle [118] and the left ventricle [49], subclavian artery stenosis due to<br />
pressure from drain tip from inside [109], Horner syndrome due to pressure on the stellate<br />
ganglion from the drain lying in the apex [21, 31], an intraabdominal placement [64], a liver<br />
puncture [47], a perforation of the stomach [4] and of the colon [1] due to diaphragmatic hernia,<br />
a lesion in the subclavian vein, perforation of the inferior vena cava [61], and triggering of atrial<br />
fibrillation [12].<br />
An arteriovenous fistula [43] as well as perforation of the cardiac wall [56] and perforation of the<br />
right atrium [104] were reported when the puncture was performed in the mid-clavicular line.<br />
In addition, other known complications are perforations of the esophagus, of the mediastinum<br />
triggering a contralateral pneumothorax, an injury to the phrenic nerve among others.<br />
Simple surgical opening: efficacy and complications<br />
The simple surgical opening of the pleural space is a suitable, effective and relatively simple<br />
intervention to decompress a tension pneumothorax. However, it is only suitable for patients on<br />
positive pressure ventilation as only they have constant positive intrapleural pressure. Negative<br />
intrapleural pressure develops in a spontaneously breathing patient and can cause air to be<br />
sucked in through the thoracotomy into the thorax.<br />
Clinical experience shows that air is released out when the pleural space is opened in a minithoracotomy<br />
to insert a pleural drain for a pneumothorax or tension pneumothorax. This release<br />
of air can be sufficient to critically improve the clinical symptoms in the case of a<br />
Prehospital – Volume replacement 64
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
hemodynamically active tension pneumothorax. This technique was examined in a case series of<br />
45 patients in prehospital use and proved itself to be effective without any major complications<br />
[50]. In a prospective observational study of a helicopter emergency rescue service over a 2-year<br />
period, 55 patients with 59 suspected pneumothoraces underwent a simple surgical opening. As a<br />
result of the procedure, arterial oxygen saturation increased on average from 86.4% to 98.5%. A<br />
pneumothorax or a hemopneumothorax was found in 91.5% of the cases. No cases of recurrent<br />
pneumothorax were observed by the authors, likewise no serious complications (major bleeding,<br />
pulmonary laceration, pleural empyema) [97].<br />
However, in another series, relevant complications were observed in 9% of patients involving<br />
non-decompressed tension pneumothoraces in just under half the cases [8].<br />
The insertion of a pleural drain via the existing mini-thoracotomy is then indicated in hospital.<br />
Needle decompression: efficacy and complications<br />
Needle decompression is a drainage procedure which is frequently effective, suitable and simple<br />
but not complication-free. Surgical decompression and the insertion of a drain must be carried<br />
out immediately if efficacy is lacking or insufficient.<br />
In a prehospital study, 47% of needle decompressions discharged air. A clinical improvement<br />
was observed in 32% of patients who underwent needle decompression[14]. In a similar study<br />
[48] , a release of air was observed during needle decompression in 32% of 89 patients with no<br />
difference between pulseless patients and those with maintained circulation. However, the<br />
release of air in ventilated patients was more frequently documented than in non-ventilated<br />
patients (34.9 versus 25.0%). However, the total rate of 60% clinical improvements remains<br />
unexplained as it is unclear how needle decompression is supposed to lead to an improvement in<br />
vital functions if no tension pneumothorax has been decompressed (i.e. no release of air). In<br />
another prospective series of 114 needle decompressions [58], there was an improvement in vital<br />
parameters or in dyspnea in 12% of patients.<br />
In contrast, in a prospective series of 14 patients (a further 5 patients died in the emergency room<br />
and were not suitable for analysis) who underwent needle decompression, in 8 patients there was<br />
no indication of there having been a pneumothorax, in 2 patients there was an occult<br />
pneumothorax, in 2 patients a persistent pneumothorax, only in one case a successfully<br />
decompressed tension pneumothorax, and in one patient a persistent tension pneumothorax [44]<br />
with the result that only one out of 14 patients had unequivocally gained from needle<br />
decompression.<br />
In the study by Barton [14], needle decompression had to be supplemented by a drain in 40% of<br />
the cases (32 out of 123) due to insufficient efficacy. In other prehospital studies [37, 48], a chest<br />
drain was additionally inserted in the prehospital phase in 53–67% of all patients undergoing<br />
needle decompression.<br />
In 4.1% of cases of detected pneumothorax, needle decompression did not work at all as the<br />
needle could not be placed far enough in. In 2.4% of cases there was a secondary dislocation of<br />
the needle and in 4.1% of punctures the needle was difficult to position. No injuries to organs<br />
Prehospital – Volume replacement 65
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
were observed [14]. In another study, needle decompression was unsuccessful in 2% of patients<br />
as the puncture was not deep enough. It was not indicated in a further 2% and an iatrogenic<br />
pneumothorax was the result. Infections and vessel injuries were not observed [58]. However,<br />
other researchers report on individual cases of lung injury [48] or cardiac tamponade [30]. In the<br />
latter case, breath sounds were absent in an unrecognized intubation of the right main bronchus.<br />
Another group reported on 3 patients with severe bleeding which necessitated a thoracotomy<br />
[119]. In addition, several case histories and case series reported a failure of needle<br />
decompression [28, 84, 110]. The most probable reason is that the needle was too short. In<br />
individual cases, a unilateral or bilateral tension pneumothorax was not identified in patients<br />
with chronic obstructive pulmonary disease (COPD) or asthma where the entire lung was not<br />
deflated [81, 108].<br />
A known problem is the l<strong>eng</strong>th of the needle used in relation to the chest wall thickness (for<br />
details, see II.2.2.1). A commonly used 4.5 cm long cannula is not sufficient in at least a quarter<br />
of patients for reaching the pleural fissure and is therefore unsuitable for decompressing a<br />
tension pneumothorax. It is not known by how much success rates could be increased if longer<br />
cannulas were used and to what extent the complication rate might increase through the longer<br />
cannula l<strong>eng</strong>th. Thus, the use of longer needles cannot be recommended.<br />
Needle decompression versus pleural drain<br />
In 2 studies, needle decompression required a significantly shorter treatment time (about 5<br />
minutes less) at the scene compared to a pleural drain (20.3 versus 25.7 min) [14, 48].<br />
Air evacuation was achieved with needle decompression in 47% of cases, but after insertion of a<br />
pleural drain it was achieved in 53.7% of patients [14].<br />
However, in a randomized study of patients with spontaneous pneumothorax (traumatic<br />
pneumothoraces were excluded here), drainage by means of a pleural drain showed a<br />
significantly higher success rate with 93% compared to simple needle aspiration (68.5%) [5]. In<br />
another prospective randomized study [112] on the same research question, 59.3% of needle<br />
aspirations and 84.9% of pleural drains were immediately successful. In 33% of patients with<br />
needle aspiration, another puncture or insertion of a pleural drain was necessary. The<br />
transferability of these data to the traumatic pneumothorax is open.<br />
Some experts do not consider needle decompression an indication unless as a last resort [63].<br />
If puncture by means of a needle is ineffective, surgical opening of the pleural space, if<br />
necessary with insertion of a drain, should be undertaken without delay or, in the case of obese<br />
patients, should be the first-line choice.<br />
Conduct<br />
Puncture site<br />
Some authors recommend needle decompression in the 2nd-3rd intercostal space in the<br />
midclavicular line [14, 40, 44, 58], whereas others recommend the anterior to midaxillary line at<br />
the level of the 5th intercostal space [22, 39, 119]. It is postulated that the thickness of the ventral<br />
Prehospital – Volume replacement 66
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
chest wall is greater than at the axillary line but this could not be confirmed in a study of<br />
cadavers (chest wall thickness in the midclavicular line [MCL]: 3.0 cm, in the midaxillary line<br />
[MAL]: 3.2 cm) [26].<br />
On the other hand, the danger of a lung injury due to adhesions is considered greater in lateral<br />
access, and air in the pleural space would more likely be found in the apex. However, there are<br />
no study results on the practical importance of the cited arguments. One study showed that there<br />
is a strong trend to puncture medial to the midclavicular line with the associated risk of injuring<br />
the heart or great vessels [110].<br />
Both the 4th-6th intercostal space in the anterior to midaxillary line [40, 132, 136] and the 2nd-<br />
3rd intercostal space in the midclavicular line are recommended as puncture sites for inserting a<br />
pleural drain. The nipple can be used as a guide in male patients. Generally, punctures must not<br />
be made below this point because the risk of an abdominal misplacement and injury to<br />
abdominal organs increases when the puncture is made too low. It should be noted that the<br />
puncture site indicated refers to the opening between the ribs. The skin incision can also lie one<br />
intercostal space lower (see conduct of puncture).<br />
Deleterious complications for both puncture sites have been published as case histories. One<br />
prospective study found that the puncture level (2nd-8th intercostal space) or the lateral position<br />
(MCL or MAL) had no effect on the success rate of draining pneumothoraces or<br />
hemopneumothoraces following sharp trauma [57]. The complications from drain insertion in the<br />
2nd-3rd intercostal space in the midclavicular line (n = 21) and in the 4th-6th intercostal space in<br />
the anterior axillary line (n = 80) were analyzed in a cohort study [82]. Although the rate of<br />
interlobal misplacements when using lateral access was significantly higher, functional<br />
misplacement was comparably frequent at both puncture sites (6.3% versus 4.5%).<br />
Instruments (needle decompression)<br />
In a study of cadavers, the average chest wall thickness was approximately 3.2 cm with a wide<br />
scatter (standard deviation 1.5 cm) [26]. Britten confirmed these results using ultrasound<br />
measurements and observed that in 57% of cases the pleural depth exceeded 3 cm and in 4% of<br />
subjects exceeded 4.5 cm. He concluded that, for the pleural space to be reached at all, the<br />
minimum l<strong>eng</strong>th of needle required in the vast majority of cases is 4.5 cm [27]. Even a 4.5 cm<br />
long needle can be too short to reach the pleural space [28]. In a more recent study [72], an<br />
average chest wall thickness at the midclavicular line of 4.16 cm in men and 4.9 cm in women<br />
was determined in trauma patients using computed tomography. A quarter of the patients had a<br />
chest wall thickness exceeding 5 cm. Marinaro et al. [95] found a chest wall thickness exceeding<br />
5 cm in 33% of their patients and even exceeding 6 cm in 10% of the injured. In a Netherlands<br />
study, the mean chest wall thickness at the midaxillary line was 3.9 cm in women and 3.4 cm in<br />
men. A needle with a l<strong>eng</strong>th of 4.5 cm would not have reached the pleural space in 10-19% of<br />
men (under versus over 40 years) and 24-35% of women (under versus over 40 years) [145]. In a<br />
comparable study design, the average chest wall thickness in military personnel was 5.4 cm [74].<br />
Some experts recommend the use of longer needles (exceeding 4.5 cm) to increase the chance of<br />
the pleural space being reached. Others fear that using longer cannulas carries a greater risk of<br />
injuring great vessels or the heart (see also [110]). There are no studies available on the actual<br />
Prehospital – Volume replacement 67
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
benefit-risk evaluation of using longer versus normal l<strong>eng</strong>th cannulas. Many experts therefore<br />
advise using the standard cannula (4.5 cm) and, if unsuccessful, surgically opening the pleural<br />
space (mini-thoracotomy).<br />
There are no data available on the cannula diameter or type of cannulas to be used. In general,<br />
the largest possible cannula diameter is recommended to allow the maximum amount of air to be<br />
released.<br />
Instruments (surgical decompression)<br />
A thin drain should also suffice for decompressing a pneumothorax. In the case of non-traumatic<br />
pneumothoraces, 75-87% of patients were successfully treated with size 8-14 French (Fr) pleural<br />
catheters [41, 96] A study of patients with pneumothorax secondary to isolated thoracic trauma<br />
showed a success rate of 75% with thin catheters (8 Fr). The remaining 25% required a chest<br />
drain [51]. One case history reports on the progression of a pneumothorax into a tension situation<br />
despite an indwelling 8-Fr drain. This was a ventilated patient with a ruptured air cyst [17].<br />
However, as at least 30% of cases after trauma are combined pneumo-/hemothoraces, it is feared<br />
that the drain may block quickly if too narrow. For these reasons, the use of 24-32-Fr drains are<br />
recommended in adults [16, 83, 132, 136].<br />
Discharge systems<br />
There are no reliable data on the question of whether and when a chest drain can be left open to<br />
the outside and, if so, which discharge system is to be used. A consensus expert recommendation<br />
also cannot be given.<br />
No closure<br />
Theoretically, the chest drain to the outside can be left open in a patient who is on positive<br />
pressure ventilation. There is a potentially increased risk of transferring infectious diseases to<br />
staff and there is contamination from the unprotected discharge of blood via the drain. On the<br />
other hand, there is only a minor risk of the discharge becoming obstructed and a recurrence of<br />
the (tension) pneumothorax.<br />
However, if the patient is spontaneously breathing, there is a danger during inspiration that air<br />
from outside can be sucked into the pleural space, leading to total collapse of the pulmonary<br />
lobe. In this situation it is necessary to insert a valve device.<br />
Heimlich valve<br />
One such commercially available valve device is the Heimlich valve. It was originally used for<br />
decompressing spontaneous pneumothoraces [20]. In one out of 18 cases, the valve stuck and<br />
there was a resulting loss of function. In a retrospective comparison, 19 patients with a Heimlich<br />
valve had a shorter drainage time and l<strong>eng</strong>th of stay in hospital compared to 57 patients with a<br />
standard drainage system (1/3 of patients with traumatic pneumothorax). However, patients with<br />
hemothorax were excluded and 4 patients with a Heimlich valve had to change to the standard<br />
drainage group [111]. Thus, it is unclear whether these experiences can be transferred to the<br />
Prehospital – Volume replacement 68
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
prehospital situation. Further case reports show that the valve can get stuck causing the outflow<br />
to be diverted and a recurrent tension pneumothorax occurred [78, 93]. Heimlich valves were<br />
routinely used during the Falklands war, where it was reported that they frequently got stuck due<br />
to blood coagulation and that the valve had to be repeatedly replaced; the problem was not<br />
quantified [142]. It was shown in experimental studies that 2 out of 8 valves had a loss of<br />
function and in 7 out of 8 cases where the Heimlich valve was past its expiry date it was<br />
defective [78]. In addition to material fatigue, coagulated blood can also cause a loss of function.<br />
This uncertainty regarding the functionality of the Heimlich valve creates an incalculable risk<br />
potential and close monitoring is necessary during use. These considerations essentially apply to<br />
all other valves with the exception of multi-bottle systems. The Heimlich valve also does not<br />
offer protection against contamination and dirt.<br />
Closed bag or chamber systems<br />
Although the attachment of a closed collection bag can reduce the danger of dirt and infection, it<br />
can rapidly fill up with air or blood if there is a relatively large air fistula and so may lead to<br />
positive pressure with tension developing again in the pleural space.<br />
Under in-patient conditions, a discharge via a 2- or 3-chamber system is generally used, these<br />
being predominantly closed commercial discharge systems. Advantages are their good<br />
functionality and protection against the surroundings being contaminated with blood. They<br />
would also be the definitive discharge system for ongoing treatment in hospital. In prehospital<br />
use, problems arise because they are awkward to handle when repositioning and during<br />
transportation and there is a resulting risk of tilting. If the chambers are overturned and there is<br />
uncontrollable displacement of the fill fluids between the chambers, their functional reliability is<br />
at risk [73].<br />
In a prospective randomized study of patients following thoracotomy, a commercially available<br />
discharge system, consisting of a safety valve, a bag and an air outlet, was as successful as a<br />
multi-chamber system with underwater seal. Blockages were not observed here although the<br />
drains also conveyed blood and bloody secretion. There are no field reports on its use in the<br />
prehospital phase for traumatic hemothoraces or for pneumothoraces.<br />
The use of a simple bag without valve (e.g., colostomy bag) [138] is not an option for trauma<br />
patients and pneumothoraces.<br />
The Xpand Drain is a new development which has a collection reservoir attached via a valve to<br />
the pleural drain. A suction unit can be attached to the collection reservoir and larger amounts of<br />
fluid can be evacuated via a separate discharge. In a randomized but not blinded study, this<br />
collection reservoir (n = 34) was compared in a hospital setting with a conventional underwater<br />
seal (n = 33) in patients with pneumo- or hemopneumothorax after penetrating trauma [42]. The<br />
Xpand Drain was shown to be operationally comparable to the underwater seal. In principle, this<br />
system has potential advantages (small, easily transportable, transient overturning appears noncritical,<br />
clean) but to date there is no published experience on its use in the prehospital phase. A<br />
recommendation, therefore, should not be made until this is available.<br />
Prehospital – Volume replacement 69
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Conduct (needle decompression)<br />
The best technique has never been examined in controlled trials so these are expert opinions.<br />
Care must be taken to select the puncture site correctly as there is a tendency to puncture medial<br />
to the midclavicular line [110]. The puncture should follow a straight path using a permanent<br />
venous cannula attached to a syringe aspirating for air, continuing until air is aspirated [40].<br />
After the pleural space has been punctured, the steel stylet should be left in situ to prevent the<br />
unprotected plastic cannula from kinking [44, 114]. Other authors hold the view that the steel<br />
stylet should be removed after puncture and only the plastic cannula left in situ[58, 110].<br />
However, kinks have been documented (1 out of 18 punctures) [110].<br />
Conduct (surgical decompression)<br />
Key recommendation:<br />
The pleural space should be opened by mini-thoracotomy. The chest drain<br />
should be inserted without using a trocar.<br />
Explanation:<br />
GoR B<br />
The best technique has never been examined in controlled trials. Most experts recommend a<br />
standardized technique: a pleural drain must be inserted using a sterile technique. After the skin<br />
has been disinfected, a local anesthetic is administered to the not fully unconscious patient down<br />
to the pleural wall. A horizontal (transverse) skin incision approximately 4-5 cm in l<strong>eng</strong>th is<br />
made with a scalpel along the upper border of the rib below the intercostal space to be punctured,<br />
or one rib lower (for cosmetic reasons this is done at the appropriate level in the sub-mammary<br />
fold in women). The subcutaneous layer and the intercostal musculature on the upper edge of the<br />
rib are opened up by blunt dissection or a clamp. The pleura can be separated by blunt dissection<br />
or by a small cut with the scissors. Then a finger (sterile glove) is inserted into the pleural space<br />
in order to verify correct access to the pleural space and ensure that there are no adhesions or, if<br />
applicable, to release them [16, 50, 107, 123, 132, 133, 136, 139]. If the ribcage is only to have a<br />
simple opening, the wound is covered with a sterile dressing, which is not taped on one side (for<br />
venting).<br />
If a chest drain is to be inserted, the intervention is continued: a subcutaneous tunnel is not<br />
considered necessary by all experts [133]. A trocar should never be used for blind preparation of<br />
the passage. Serious complications have occurred through its use such as the perforation to the<br />
right atrium in a patient with kyphoscoliosis [104] or perforations to the lung [65]. The<br />
complication rates in studies on the trocar technique are much higher than in the studies on the<br />
surgical technique (11.0% versus 1.6%) (Appendix). In a prospective cohort study (on intensive<br />
care patients), it was shown that the use of a trocar was associated with a significantly higher rate<br />
of misplacements [120]. At the moment of transsectioning the pleura and inserting the drain,<br />
some experts recommend ventilated patients have a short ventilation break to reduce the risk of<br />
injury to the lung parenchyma when the lung is expanded [65, 115, 116].<br />
Prehospital – Volume replacement 70
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The chest drain is then inserted through the prepared passage. The finger inserted in parallel can<br />
be used as a guide. The tip of the drain can also be held in a clamp and guided using this more<br />
rigid guiding option. Alternatively, a trocar can be used to guide the drain (not for preparing or<br />
perforating the chest wall!). It must be ensured that the tip of the trocar never protrudes beyond<br />
the tip of the drain and that no force is applied in advancing the drain [136].<br />
The drain must be prevented from dislocating by fixing steristrips or a suture. A self-locking<br />
plastic tie can also be used for fixation [105].<br />
Alternative techniques for insertion<br />
A series of alternative techniques and modifications to the mini-thoracotomy for evacuating the<br />
pleural space have been published. They have usually been published simply as a description of<br />
the technique or examined in small case series or studies. There is usually no description of<br />
prehospital use or use in trauma patients. For these reasons, there are no perspectives that appear<br />
to justify use of these techniques as an equivalent alternative to the standard mini-thoracotomy<br />
described for trauma patients in the prehospital phase. Although there are no scientific proofs of<br />
the superiority of the standard technique either, it is the unanimous opinion of the experts that<br />
empirical experiences justify the recommendation of the standard technique as long as the<br />
alternative procedures have not supplied evidence of equivalence or superiority under the abovementioned<br />
conditions.<br />
Altman [3] modified the standard technique using mini-thoracotomy such that a Tiemann<br />
catheter consistent with the Seldinger technique is first inserted with a clamp into the pleural<br />
space and then serves as a guide bar for the actual drain. This enables a smaller skin incision<br />
compared to the standard technique.<br />
The use of a laparoscopic trocar catheter is a technique that has been well-studied compared to<br />
numerous other alternative guide techniques but not in direct comparison with the standard<br />
technique [18, 67, 86, 92, 140]. Technique and complications were described in a prospective<br />
cohort study in which 112 patients were included, 39 of them after trauma [140]. The only<br />
complication (0.89%) described was an injury to the lung.<br />
In 1988 Thal and Quick described a technique involving the insertion of a guidewire after direct<br />
puncture and expansion of the puncture passage using increasingly larger dilators and insertion<br />
of the drain (up to 32 Fr) over the guidewire [113, 134]. The technique led to an initial success in<br />
24 pediatric patients (14 pneumothoraces, 3 hemothoraces, 7 others). In 5 cases (approx. 20%)<br />
there were complications due to kinking in the 10-20 Fr catheters [2]. In a systematic review, no<br />
advantages in the Seldinger technique could be confirmed compared to other techniques [6].<br />
A frequent alternative, used particularly in pediatrics, is pigtail catheters with narrow lumen (7-8<br />
Fr) inserted by direct puncture (with or without the Seldinger technique). Gammie et al. [68, 69]<br />
used an 8.3 Fr pigtail catheter in 109 partially-ventilated patients (10 trauma patients). The<br />
success rate was 86% for pleural effusions (no hemothorax) and 81% for pneumothoraces<br />
(predominantly not traumatic). Roberts reports a complication rate of 11% insufficient drainage,<br />
2% each hemo- and pneumothoraces, 1% liver perforation and 2% kinking or compression<br />
through the chest wall. The drainage success was insufficient particularly in pneumothoraces<br />
Prehospital – Volume replacement 71
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
(25%) and hemothoraces (15%) [121]. There was a failure rate of 25% with 8-Fr catheters which<br />
were inserted using guidewire in 16 adult patients with traumatic pneumothorax [51].<br />
Transferability to acute trauma patients remains unclear.<br />
Other techniques have been suggested such as inserting a guidewire, subsequent dilation using a<br />
Howard Kelly clamp and then inserting the drain via the dilated passage [106].<br />
In a small prospective randomized study, Röggla et al. [122] compared the standard pleural drain<br />
(14 Fr trocar, 13 patients) with the Tru-Close® Thoracic Vent catheter with valve and integrated<br />
collection chamber (17 patients) in spontaneous or iatrogenic pneumothorax. With a comparable<br />
success rate for re-expansion, the patients with the Thoracic Vent had less need of analgesics and<br />
could be treated more frequently as outpatients. As hemothoraces and ventilated patients were<br />
excluded, it is not possible to transfer these results to prehospital trauma patients.<br />
At the end of the 1970s, McSwain developed a system for a prehospital chest drain (15 Fr),<br />
called the McSwain Dart ® [102, 103], which most closely resembles a basket catheter, which is<br />
inserted via a puncture using a cannula. In a case series of 40 patients [141], the McSwain Dart<br />
revealed good effectiveness with 2 (5%) complications (diaphragm injury and intercostal artery<br />
lesion). The authors explained that some of the catheters were later blocked by blood and had to<br />
be replaced. The device was not considered suitable for draining a hemothorax. In a study of<br />
dogs, the McSwain Dart frequently caused injuries to the lung parenchyma if no pneumothorax<br />
was present [15].<br />
Gill et al. [71] developed a 5 cm long, conical, expandable, puncture cannula with a 10 mm<br />
diameter, which was pushed through the pleural drain and studied in 22 patients.<br />
Prehospital – Volume replacement 72
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Ahmed-Nusrath A, Nusrath Ma, Annamaneni R<br />
(2007) Faecal mediastinitis following decompression<br />
of suspected tension pneumothorax. Emerg Med J<br />
24:830 [LoE 5]<br />
2. Ahmed My, Silver P, Nimkoff L et al. (1995) The<br />
needle-wire-dilator technique for the insertion of chest<br />
tubes in pediatric patients. Pediatr Emerg Care<br />
11:252-254. [LoE 4]<br />
3. Altman E, Ben-Nun A, Curtis Wj et al. (2001)<br />
Modified Seldinger technique for the insertion of<br />
standard chest tubes. Am J Surg 181:354-355 [LoE 5]<br />
4. Andrabi Sa, Andrabi Si, Mansha M et al. (2007) An<br />
iatrogenic complication of closed tube thoracostomy<br />
for penetrating chest trauma. N Z Med J 120:U2784<br />
[LoE 5]<br />
5. Andrivet P, Djedaini K, Teboul J et al. (1995)<br />
Spontaneous pneumotho-rax: comparison of thoracic<br />
drainage vs. Immediate or delayed needle aspiration.<br />
Chest 108:335-338 [LoE 4]<br />
6. Argall J, Desmond J (2003) Seldinger technique chest<br />
drains and complication rate. Emerg Med J 20:169-<br />
170 [LoE 1]<br />
7. Aufmkolk M, Ruchholtz S, Hering M et al. (2003)<br />
Wertigkeit der subjektiven Einschätzung der<br />
Thoraxverletzungsschwere durch den Notarzt.<br />
Unfallchirurg 106:746-753 [LoE 4]<br />
8. Aylwin Cj, Brohi K, Davies Gd et al. (2008) Prehospital<br />
and in-hospital thoracostomy: indications and<br />
complications. Ann R Coll Surg Engl 90:54-57 [LoE<br />
3]<br />
9. Bailey Rc (2000) Complications of tube thoracostomy<br />
in trauma. J Accid Emerg Med 17:111-114 [LoE 4]<br />
10. Baldt M, Bankier A, Germann P et al. (1995)<br />
Complications after emergency tube thoracostomy:<br />
assessment with CT. Radiology 195:539-543 [LoE 4]<br />
11. Ball Cg, Lord J, Laupland Kb et al. (2007) Chest tube<br />
complications: how well are we training our<br />
residents? Can J Surg 50:450-458 [LoE 2]<br />
12. Barak M, Iaroshevski D, Ziser A (2003) Rapid atrial<br />
fibrillation following tube thoracostomy insertion. Eur<br />
J Cardiothorac Surg 24:461-462 [LoE 5]<br />
13. Barton E (1999) Tension pneumothorax. Curr Opin<br />
Pulm Med 5:269-274 [LoE 5]<br />
14. Barton E, Epperson M, Hoyt D et al. (1995)<br />
Prehospital needle aspiration and tube thoracostomy<br />
in trauma victims: a six-year experience with<br />
aeromedical crews. J Emerg Med 13:155-163 [LoE 4]<br />
15. Bayne Cg (1982) Pulmonary complications of the<br />
McSwain Dart. Ann Emerg Med 11:136-137 [LoE 5]<br />
16. Beall Ac, Jr., Bricker Dl, Crawford Hw et al. (1968)<br />
Considerations in the management of penetrating<br />
thoracic trauma. J Trauma 8:408-417 [LoE 4]<br />
17. Behnia Mm, Garrett K (2004) Association of tension<br />
pneumothorax with use of small-bore chest tubes in<br />
patients receiving mechanical ventilation. Crit Care<br />
Nurse 24:64-65 [LoE 5]<br />
18. Ben Ze'ev I (1995) Percutaneous thoracostomy with<br />
plastic-shielded locking trocar. J Thorac Cardiovasc<br />
Surg 110:273 [LoE 5]<br />
19. Bergaminelli C, De Angelis P, Gauthier P et al. (1999)<br />
Thoracic drainage in trauma emergencies. Minerva<br />
Chir 54:697-702 [LoE 4]<br />
20. Bernstein A, Waqaruddin M, Shah M (1973)<br />
Management of spontaneous pneumothorax using a<br />
Heimlich flutter valve. Thorax 28:386-389 [LoE 4]<br />
21. Bertino Re, Wesbey Ge, Johnson Rj (1987) Horner<br />
syndrome occurring as a complication of chest tube<br />
placement. Radiology 164:745 [LoE 5]<br />
22. Biffl Wl (2004) Needle thoracostomy: a cautionary<br />
note. Acad Emerg Med 11:795-796; author reply 796<br />
[LoE 5]<br />
23. Blostein P, Hodgman C (1997) Computed<br />
tomography of the chest in blunt thoracic trauma:<br />
results of a prospective study. J Trauma 43:13-18<br />
[LoE 2]<br />
24. Bokhari F, Brakenridge S, Nagy K et al. (2002)<br />
Prospective evaluation of the sensitivity of physical<br />
examination in chest trauma. J Trauma 53:1135-1138<br />
[LoE 2]<br />
25. Brasel K, Stafford R, Weigelt J et al. (1999)<br />
Treatment of occult pneumothoraces from blunt<br />
trauma. J Trauma 46:987-990 [LoE 1]<br />
26. Bristol Jb, Harvey Je (1983) Safer insertion of pleural<br />
drains. Br Med J (Clin Res Ed) 286:348-349 [LoE 5]<br />
27. Britten S, Palmer Sh (1996) Chest wall thickness may<br />
limit adequate drainage of tension pneumothorax by<br />
needle thoracocentesis. J Accid Emerg Med 13:426-<br />
427 [LoE 2]<br />
28. Britten S, Palmer Sh, Snow Tm (1996) Needle<br />
thoracocentesis in tension pneumothorax: insufficient<br />
cannula l<strong>eng</strong>th and potential failure. Injury 27:321-<br />
322 [LoE 4]<br />
29. Bushby N, Fitzgerald M, Cameron P et al. (2005)<br />
Prehospital intubation and chest decompression is<br />
associated with unexpected survival in major thoracic<br />
blunt trauma. Emerg Med Australas 17:443-449 [LoE<br />
3]<br />
30. Butler Kl, Best Im, Weaver Wl et al. (2003)<br />
Pulmonary artery injury and cardiac tamponade after<br />
needle decompression of a suspected tension<br />
pneumothorax. J Trauma 54:610-611 [LoE 5]<br />
31. Campbell P, Neil T, Wake Pn (1989) Horner's<br />
syndrome caused by an intercostal chest drain. Thorax<br />
44:305-306 [LoE 4]<br />
32. Carney M, Ravin Ce (1979) Intercostal artery<br />
laceration during thoracocentesis: increased risk in<br />
elderly patients. Chest 75:520-522 [LoE 4]<br />
33. Casillas Ja, De La Fuente A (1983) Right atrium<br />
perforation by a pleural drain. Report of a case with<br />
survival. Thorac Cardiovasc Surg 31:247-248 [LoE 4]<br />
34. Chan L, Reilly Km, Henderson C et al. (1997)<br />
Complication rates of tube thoracostomy. Am J Emerg<br />
Med 15:368-370 [LoE 4]<br />
35. Chen S, Chang K, Hsu C (1998) Accuracy of<br />
auscultation in the detection of haemopneumothorax.<br />
Eur J Surg 164:643-645 [LoE 1]<br />
Prehospital – Volume replacement 73
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
36. Chen S, Markmann J, Kauder D et al. (1997)<br />
Hemopneumothorax missed by auscultation in<br />
penetrating chest injury. J Trauma 42:86-89 [LoE 3]<br />
37. Coats T, Wilson A, Xeropotamous N (1995) Prehospital<br />
management of patients with severe thoracic<br />
injury. Injury 26:581-585 [LoE 4]<br />
38. Collins J, Levine G, Waxman K (1992) Occult<br />
traumatic pneumothorax: immediate tube<br />
thoracostomy versus expectant management. Am Surg<br />
58:743-746 [LoE 4]<br />
39. Committee on Trauma (2001) Advanved Trauma Life<br />
Support (ATLS ® ) - Reference Manual. American<br />
College of Surgeons, Chicago [LoE 5]<br />
40. Committee on Trauma (1997) Advanved Trauma Life<br />
Support (ATLS ® ) - Reference Manual. American<br />
College of Surgeons, Chicago [LoE 5]<br />
41. Conces Dj, Jr., Tarver Rd, Gray Wc et al. (1988)<br />
Treatment of pneumothoraces utilizing small caliber<br />
chest tubes. Chest 94:55-57 [LoE 4]<br />
42. Cooper C, Hardcastle T (2006) Xpand chest drain:<br />
assessing equivalence to current standard therapy--a<br />
randomised controlled trial. S Afr J Surg 44:131-135<br />
[LoE 1]<br />
43. Cox Pa, Keshishian Jm, Blades Bb (1967) Traumatic<br />
arteriovenous fistula of the chest wall and lung.<br />
Secondary to insertion of an intercostal catheter. J<br />
Thorac Cardiovasc Surg 54:109-112 [LoE 4]<br />
44. Cullinane D, Morris J, Bass J et al. (2001) Needle<br />
thoracostomy may not be indicated in the trauma<br />
patient. Injury 32:749-752 [LoE 4]<br />
45. Curtin J, Goodman L, Quebbeman E et al. (1994)<br />
Thoracostomy tubes after acute chest injury:<br />
relationship between location in a pleural fissure and<br />
function. AJR 163:1.339-1.342 [LoE 4]<br />
46. Daly Rc, Mucha P, Pairolero Pc et al. (1985) The risk<br />
of percutaneous chest tube thoracostomy for blunt<br />
thoracic trauma. Ann Emerg Med 14:865-870 [LoE 4]<br />
47. David A (1985) Thoraxsaugdrainagen bei der<br />
Erstversorgung von Brustkorbverletzungen.<br />
Notfallmedizin 11:1481 [LoE 4]<br />
48. Davis Dp, Pettit K, Rom Cd et al. (2005) The safety<br />
and efficacy of prehospital needle and tube<br />
thoracostomy by aeromedical personnel. Prehosp<br />
Emerg Care 9:191-197 [LoE 2]<br />
49. De La Fuente A, Sanchez R, Suarez J et al. (1994)<br />
Left ventricular perforation by a pleural drainage tube.<br />
Report of a case with survival. Tex Heart Inst J<br />
21:175-176 [LoE 4]<br />
50. Deakin C, Davies G, Wilson A (1995) Simple<br />
thoracostomy avoids chest drain insertion in<br />
prehospital trauma. J Trauma 39:373-374 [LoE 4]<br />
51. Delius R, Obed F, Horst M et al. (1989) Catheter<br />
aspiration for simple pneumothorax. Arch Surg<br />
124:833-836 [LoE 3]<br />
52. Demartines N, Kiener A, Scheidegger D et al. (1990)<br />
Thoracic drainage at the accident site]. Helv Chir Acta<br />
57:273-277 [LoE 4]<br />
53. Demartines N, Kiener A, Scheidegger D et al. (1990)<br />
[Thoracic drainage at the accident site]. Helv Chir<br />
Acta 57:273-277 [LoE 4]<br />
54. Deneuville M (2002) Morbidity of percutaneous tube<br />
thoracostomy in trauma patients. Eur J Cardiothorac<br />
Surg 22:673-678 [LoE 2]<br />
55. Di Bartolomeo S, Sanson G, Nardi G et al. (2001) A<br />
population-based study on pneumothorax in severely<br />
traumatized patients. J Trauma 51:677-682 [LoE 4]<br />
56. Dominguez Fernandez E, Neudeck F, Piotrowski J<br />
(1995) [Perforation of the heart wall--a rare<br />
complication after thoracic drainage treatment].<br />
Chirurg 66:920-922 [LoE 4]<br />
57. Duponselle Ef (1980) The level of the intercostal<br />
drain and other determinant factors in the conservative<br />
approach to penetrating chest injuries. Cent Afr J Med<br />
26:52-55 [LoE 4]<br />
58. Eckstein M, Suyehara D (1998) Needle thoracostomy<br />
in the prehospital setting. Prehosp Emerg Care 2:132-<br />
135 [LoE 2]<br />
59. Eddy A, Luna G, Copass M (1989) Empyema thoracis<br />
in patients undergoing emergent closed tube<br />
thoracostomy for thoracic trauma. Am J Surg<br />
157:494-497 [LoE 4]<br />
60. Enderson B, Abdalla R, Frame S et al. (1993) Tube<br />
thoracostomy for occult pneumothorax: a prospective<br />
randomized study of its use. J Trauma 35:726-729<br />
[LoE 1]<br />
61. Eriksson A (1982) Fatal latrogenic exsanguination<br />
from pleural drain insertion into the inferior cava.<br />
Thorac Cardiovasc Surg 30:191-193 [LoE 4]<br />
62. Etoch S, Bar-Natan M, Miller F et al. (1995) Tube<br />
thoracostomy. Factors related to complications. Arch<br />
Surg 130:521-525 [LoE 4]<br />
63. Fitzgerald M, Mackenzie Cf, Marasco S et al. (2008)<br />
Pleural decompression and drainage during trauma<br />
reception and resuscitation. Injury 39:9-20 [LoE 5]<br />
64. Foresti V, Villa A, Casati O et al. (1992) Abdominal<br />
placement of tube thoracostomy due to lack of<br />
recognition of paralysis of hemidiaphragm. Chest<br />
102:292-293 [LoE 5]<br />
65. Fraser Rs (1988) Lung perforation complicating tube<br />
thoracostomy: pathologic description of three cases.<br />
Hum Pathol 19:518-523 [LoE 4]<br />
66. Gaillard M, Herve C, Mandin L et al. (1990) Mortality<br />
prognostic factors in chest injury. J Trauma 30:93-96<br />
[LoE 3]<br />
67. Galloway P, King P, Freeland P et al. (1993) Use of<br />
Autosuture Surgiport for pleural drain insertion.<br />
Injury 24:538-540 [LoE 4]<br />
68. Gammie Js, Banks Mc, Fuhrman Cr et al. (1999) The<br />
pigtail catheter for pleural drainage: a less invasive<br />
alternative to tube thoracostomy. JSLS 3:57-61 [LoE<br />
4]<br />
69. Gammie Js, Banks Mc, Fuhrman Cr et al. (1999) The<br />
pigtail catheter for pleural drainage: a less invasive<br />
alternative to tube thoracostomy. Jsls 3:57-61 [LoE 4]<br />
70. Garramone Rj, Jacobs L, Sahdev P (1991) An<br />
objective method to measure and manage occult<br />
pneumothorax. Surg Gynecol Obstet 173:257-261<br />
[LoE 4]<br />
71. Gill S, Nkere U, Walesby R (1992) An expansible<br />
cannula: a new technique for chest drain insertion.<br />
Thorax 47: 657-659 [LoE 4]<br />
Prehospital – Volume replacement 74
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
72. Givens M, Ayotte K, Manifold C (2004) Needle<br />
thoracostomy: impilcations of computed tomography<br />
chest wall thickness. Acad Emerg Med 11:211-313<br />
[LoE 3]<br />
73. Graham An, Cosgrove Ap, Gibbons Jr et al. (1992)<br />
Randomised clinical trial of chest drainage systems.<br />
Thorax 47:461-462 [LoE 2]<br />
74. Harcke Ht, Pearse La, Levy Ad et al. (2007) Chest<br />
wall thickness in military personnel: implications for<br />
needle thoracentesis in tension pneumothorax. Mil<br />
Med 172:1260-1263 [LoE 2]<br />
75. Heim P, Maas R, Tesch C et al. (1998) [Pleural<br />
drainage in acute thoracic trauma. Comparison of the<br />
radiologic image and computer tomography]. Aktuelle<br />
Radiol 8:163-168 [LoE 4]<br />
76. Helling T, Gyles N, Eisenstein C et al. (1989)<br />
Complications following blunt and penetrating<br />
injuries in 216 victims of chest trauma requiring tube<br />
thoracostomy. J Trauma 29:1367-1370 [LoE 4]<br />
77. H<strong>eng</strong> K, Bystrzycki A, Fitzgerald M et al. (2004)<br />
Complications of intercostal catheter insertion using<br />
EMST techniques for chest trauma. ANZ J Surg<br />
74:420-423 [LoE 4]<br />
78. Hiebl A (2001) Problematik von Heimlich-Ventilen in<br />
der Notfallversorgung. In:Medizinischen Fakultät der<br />
Ludwig-Maximilians-Universität, München [LoE 4]<br />
79. Hing A, Caldwell E, Nguyen T et al. (2001) Prehospital<br />
care of gun shot and stabbing injuries: an<br />
evaluation of practice and clinical outcome.<br />
Prehospital Immediate Care 5:6-11 [LoE 4]<br />
80. Hirshberg A, Thomson S, Huizinga W (1988)<br />
Reliability of physical examination in penetrating<br />
chest injuries. Injury 19:407-409 [LoE 1]<br />
81. Hostetler Ma, Davis Co (1999) Bilateral localized<br />
tension pneumothoraces refractory to needle<br />
decompression. Pediatr Emerg Care 15:322-324 [LoE<br />
4]<br />
82. Huber-Wagner S, Korner M, Ehrt A et al. (2007)<br />
Emergency chest tube placement in trauma care -<br />
which approach is preferable? Resuscitation 72:226-<br />
233 [LoE 2]<br />
83. Hyde J, Sykes T, Graham T (1997) Reducing<br />
morbidity from chest drains. Bmj 314:914-915 [LoE<br />
5]<br />
84. Jenkins C, Sudheer P (2000) Needle thoracocentesis<br />
fails to diagnose a large pneumothorax. Anaesthesia<br />
55:925-926 [LoE 4]<br />
85. Johnson G (1996) Traumatic pneumothorax: is a chest<br />
drain always necessary? J Accid Emerg Med 13:173-<br />
174 [LoE 4]<br />
86. Kang Ss (1994) Use of the disposable laparoscopic<br />
trocar-cannula for chest tube insertion. J Am Coll<br />
Surg 179:230 [LoE 5]<br />
87. Kirkpatrick Aw (2007) Clinician-performed focused<br />
sonography for the resuscitation of trauma. Crit Care<br />
Med 35:S162-172 [LoE 5]<br />
88. Lechleuthner A, Bouillon B, Neugebauer E et al.<br />
(1994) Prehospital chest tubes - incidence of<br />
iatrogenic injries in der emergency medical service<br />
Cologne. Theor Surg 9:220-226 [LoE 4]<br />
89. Lee C, Revell M, Porter K et al. (2007) The<br />
prehospital management of chest injuries: a consensus<br />
statement. Faculty of Pre-hospital Care, Royal College<br />
of Surgeons of Edinburgh. Emerg Med J 24:220-224<br />
[LoE 5]<br />
90. Leigh-Smith S, Davies G (2003) Tension<br />
pneumothorax: eyes may be more diagnostic than<br />
ears. Emerg Med J 20:495-496 [LoE 5]<br />
91. Leigh-Smith S, Harris T (2005) Tension<br />
pneumothorax - time for a re-think. Emerg Med J<br />
22:8-16 [LoE 1]<br />
92. Lyass S, Simha M, Muggia-Sullam M (1995) Use of a<br />
laparoscopic trocar for tube thoracostomy--a rapid and<br />
safe method for chest tube placement. Eur J Emerg<br />
Med 2:96 [LoE 5]<br />
93. Mainini Se, Johnson Fe (1990) Tension pneumothorax<br />
complicating small-caliber chest tube insertion. Chest<br />
97:759-760 [LoE 4]<br />
94. Mandal A, Thadepalli H, Mandal A et al. (1997)<br />
Posttraumatic empyema thoracis: a 24-year<br />
experience at a major trauma center. J Trauma<br />
43:764-771 [LoE 5]<br />
95. Marinaro Jl, Kenny Cv, Smith Sr et al. (2003) Needle<br />
Thoracostomy in Trauma Patients: What Catheter<br />
L<strong>eng</strong>th Is Adequate? Acad Emerg Med 10:495 [LoE<br />
3]<br />
96. Martin T, Fontana G, Olak J et al. (1996) Use of<br />
pleural catheter for the management of simple<br />
pneumothorax. Chest 110:1169-1172 [LoE 5]<br />
97. Massarutti D, Trillo G, Berlot G et al. (2006) Simple<br />
thoracostomy in prehospital trauma management is<br />
safe and effective: a 2-year experience by helicopter<br />
emergency medical crews. Eur J Emerg Med 13:276-<br />
280 [LoE 2]<br />
98. McConaghy Pm, Kennedy N (1995) Tension<br />
pneumothorax due to intrapulmonary placement of<br />
intercostal chest drain. Anaesth Intensive Care<br />
23:496-498 [LoE 4]<br />
99. Mcintosh N, Becher Jc, Cunningham S et al. (2000)<br />
Clinical diagnosis of pneumothorax is late: use of<br />
trend data and decision support might allow<br />
preclinical detection. Pediatr Res 48:408-415 [LoE 4]<br />
100. Mcpherson Jj, Feigin Ds, Bellamy Rf (2006)<br />
Prevalence of tension pneumothorax in fatally<br />
wounded combat casualties. J Trauma 60:573-578<br />
[LoE 2]<br />
101. Mcroberts R, Mckechnie M, Leigh-Smith S (2005)<br />
Tension pneumothorax and the "forbidden CXR".<br />
Emerg Med J 22:597-598 [LoE 5]<br />
102. Mcswain Ne, Jr. (1982) The McSwain Dart: device<br />
for relief of tension pneumothorax. Med Instrum<br />
16:249-250 [LoE 5]<br />
103. Mcswain Ne, Jr. (1977) A thoracostomy tube for field<br />
and emergency department use. Jacep 6:324-325 [LoE<br />
4]<br />
104. Meisel S, Ram Z, Priel I et al. (1990) Another<br />
complication of thoracostomy - perforation of the<br />
right atrium. Chest 98:772-773 [LoE 4]<br />
105. Melamed E, Blumenfeld A, Lin G (2007) Locking<br />
plastic tie--a simple technique for securing a chest<br />
tube. Prehosp Disaster Med 22:344-345 [LoE 5]<br />
Prehospital – Volume replacement 75
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
106. Mellor Dj (1996) A new method of chest drain<br />
insertion. Anaesthesia 51:713-714 [LoE 5]<br />
107. Millikan Js, Moore Ee, Steiner E et al. (1980)<br />
Complications of tube thoracostomy for acute trauma.<br />
Am J Surg 140:738-741 [LoE 4]<br />
108. Mines D, Abbuhl S (1993) Needle thoracostomy fails<br />
to detect a fatal tension pneumothorax. Ann Emerg<br />
Med 22:863-866 [LoE 4]<br />
109. Moskal T, Liscum K, Mattox K (1997) Subclavian<br />
artery obstruction by tube thoracostomy. J Trauma<br />
43:368-369 [LoE 4]<br />
110. Netto Fa, Shulman H, Rizoli Sb et al. (2008) Are<br />
needle decompressions for tension pneumothoraces<br />
being performed appropriately for appropriate<br />
indications? Am J Emerg Med 26:597-602 [LoE 2]<br />
111. Niemi T, Hannukainen J, Aarnio P (1999) Use of the<br />
Heimlich valve for treating pneumothorax. Ann Chir<br />
Gynaecol 88:36-37 [LoE 2]<br />
112. Noppen M, Alexander P, Driesen P et al. (2002)<br />
Manual aspiration versus chest tube drainage in first<br />
episodes of primary spontaneous Pneumothorax. Am J<br />
Respir Crit Care Med 165:1240-1244 [LoE 4]<br />
113. Nosher Jl, Siegel R (1993) Over-the-wire placement<br />
of large bore thoracostomy tubes. Cardiovasc<br />
Intervent Radiol 16:195-197 [LoE 4]<br />
114. Pattison Gt (1996) Needle thoracocentesis in tension<br />
pneumothorax: insufficient cannula l<strong>eng</strong>th and<br />
potential failure. Injury 27:758 [LoE 4]<br />
115. Peek G, Firmin R (1997) Reducing morbidity from<br />
insertion of chest drains. BMJ 315:313 [LoE 5]<br />
116. Peek Gj, Firmin Rk, Arsiwala S (1995) Chest tube<br />
insertion in the ventilated patient. Injury 26:425-426<br />
[LoE 4]<br />
117. Peters S, Wolter D, Schultz J (1996) [Dangers and<br />
risks of thoracic drainage at the accident site].<br />
Unfallchirurg 99:953-957 [LoE 4]<br />
118. Rashid M, Acker A (1998) Cardiac herniation with<br />
catheterization of the heart, inferior vena cava, and<br />
hepatic vein vy a chest tube. J Trauma 45:407-409<br />
[LoE 4]<br />
119. Rawlins R, Brown Km, Carr Cs et al. (2003) Life<br />
threatening haemorrhage after anterior needle<br />
aspiration of pneumothoraces. A role for lateral needle<br />
aspiration in emergency decompression of<br />
spontaneous pneumothorax. Emerg Med J 20:383-384<br />
[LoE 5]<br />
120. Remerand F, Luce V, Badachi Y et al. (2007)<br />
Incidence of chest tube malposition in the critically ill:<br />
a prospective computed tomography study.<br />
Anesthesiology 106:1.112-1.119 [LoE 2]<br />
121. Roberts J, Bratton S, Brogan T (1998) Efficacy and<br />
complications of percutaneous pigtail catheters for<br />
thoracostomy in pediatric patients. Chest 114:1.116-<br />
1.121 [LoE 4]<br />
122. Röggla M, Wagner A, Brunner C et al. (1996) The<br />
management of pneumothorax with the thoracic vent<br />
versus conventional intercostal tube drainage. Wien<br />
Klin Wochenschr 108:330-333 [LoE 2]<br />
123. Rüter A, Trentz O, Wagner M (1995) Thorax-<br />
Akuttherapie: Minithorakotomie als empfohlenes<br />
Vorgehen. In: Rüter A, Trentz O, Wagner M (eds)<br />
Unfallchirurgie. Urban&Schwarzenberg, München<br />
Wien Baltimore, p 315-316 [LoE 5]<br />
124. Rutherford Rb, Hurt Hh, Jr., Brickman Rd et al.<br />
(1968) The pathophysiology of progressive, tension<br />
pneumothorax. J Trauma 8:212-227 [LoE 5]<br />
125. Schmidt U, Stalp M, T G et al. (1998) Chest<br />
decompression of blunt chest injuries by physician in<br />
the field: effectiveness and complications. J Trauma<br />
44:98-100 [LoE 4]<br />
126. Schöchl H (1994) Präklinische Versorgung des<br />
schweren Thoraxtraumas. Notfallmedizin 6:310 [LoE<br />
4]<br />
127. Shih C, Chang Y, Lai S (1992) Successful<br />
management of perforating injury of right atrium by<br />
chest tube. Chung Hua I Hsueh Tsa Chih 50:338-340<br />
[LoE 4]<br />
128. Spanjersberg W, Ringburg A, Bergs B et al. (2005)<br />
Prehospital chest tube thoracostomy: effective<br />
treatment or additional trauma? J Trauma 59:96-101<br />
[LoE 2]<br />
129. Sriussadaporn S, Poomsuwan P (1995) Post-traumatic<br />
empyema thoracis in blunt chest trauma. J Med Assoc<br />
Thai 78:393-398 [LoE 4]<br />
130. Steier M, Ching N, Roberts Eb et al. (1974)<br />
Pneumothorax complicating continuous ventilatory<br />
support. J Thorac Cardiovasc Surg 67:17-23<br />
131. Subotich D, Mandarich D (2005) Accidentally created<br />
tension pneumothorax in patient with primary<br />
spontaneous pneumothorax--confirmation of the<br />
experimental studies, putting into question the<br />
classical explanation. Med Hypotheses 64:170-173<br />
[LoE 5]<br />
132. Symbas P (1989) Chest drainage tubes. Surg Clin N<br />
Am 69:41-46 [LoE 5]<br />
133. Tang A, Hooper T, Hasan R (1999) A regional survey<br />
of chest drains: evidence-based practice? Postgrad<br />
Med J 75:471-474 [LoE 5]<br />
134. Thal Ap, Quick Kl (1988) A guided chest tube for<br />
safe thoracostomy. Surg Gynecol Obstet 167:517<br />
[LoE 5]<br />
135. Thomson S, Huizinga W, Hirshberg A (1990)<br />
Prospective study of the yield of physical examination<br />
compared with chest radiography in penetrating<br />
thoracic trauma. Thorax 45:616-619 [LoE 1]<br />
136. Tomlinson Ma, Treasure T (1997) Insertion of a chest<br />
drain: how to do it. Br J Hosp Med 58:248-252 [LoE<br />
5]<br />
137. Trupka A, Waydhas C, Hallfeldt Kkj et al. (1997) The<br />
value of thoracic computed tomography in the first<br />
assessment of severely injured patients with blunt<br />
chest trauma. J Trauma 43:405-411 [LoE 2]<br />
138. Velanovich V, Adams C (1988) The use of colostomy<br />
bags for chest tube drainage. Ann Thorac Surg<br />
46:697-698 [LoE 5]<br />
139. Velez Se, Sarquis G (2006) [Utility of digital<br />
thoracotomy in chest trauma]. Rev Fac Cien Med<br />
Univ Nac Cordoba 63:7-10 [LoE 3]<br />
140. Waksman I, Bickel A, Szabo A et al. (1999) Use of<br />
endoscopic trocar-cannula for chest drain insertion in<br />
trauma patients and others. J Trauma 46:941-943<br />
[LoE 4]<br />
Prehospital – Volume replacement 76
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
141. Wayne Ma, Mcswain Ne, Jr. (1980) Clinical<br />
evaluation of a new device for the treatment of tension<br />
pneumothorax. Ann Surg 191:760-762 [LoE 4]<br />
142. Williams Jg, Riley Tr, Moody Ra (1983)<br />
Resuscitation experience in the Falkland Islands<br />
campaign. Br Med J (Clin Res Ed) 286:775-777 [LoE<br />
4]<br />
143. Wormald P, Knottenbelt J, Linegar A (1989) A triage<br />
system for stab wounds to the chest. S Afr Med J<br />
76:211-212 [LoE 3]<br />
144. York D, Dudek L, Larson R et al. (1993) A<br />
comparison study of chest tube thoracostomy: air<br />
medical crew and in- hospital trauma service. Air Med<br />
J 12:227-229<br />
145. Z<strong>eng</strong>erink I, Brink Pr, Laupland Kb et al. (2008)<br />
Needle thoracostomy in the treatment of a tension<br />
pneumothorax in trauma patients: what size needle? J<br />
Trauma 64:111-114 [LoE 2]<br />
Prehospital – Volume replacement 77
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Appendix<br />
Table 10: Complications when inserting a pleural drain<br />
Author N SC IP IA PE MF PS Technique Site QF Comments<br />
Baldt et al. [10] 77 2.6% 6.4% 0 3.9 21% * no data<br />
trocar and<br />
blunt<br />
Barton et al. [14] 207 1.2% 0 1.2% § 0 14.2% MAL no data PRE<br />
Bailey et al. [9] 57 0 0 0 1.8% no data MAL blunt<br />
Bergaminelli et<br />
al. [19]<br />
Prehospital – Volume replacement 83<br />
PRE EP<br />
Flight<br />
nurse<br />
191 1.0% 0.6% no data 2.6% no data no data no data no data no data<br />
Chan et al. [34] 373 no data no data no data 1.1% 15% * no data no data<br />
Curtin [45] 66 0 1.5% 4.5%<br />
no<br />
data<br />
ED<br />
ICU<br />
ED,<br />
OR,<br />
ward<br />
EDP<br />
SURG<br />
EDP<br />
18% * no data no data ED SURG<br />
Daly et al. [46] 164 0.6% 0.6% 0.6% 1.2% no data MAL blunt<br />
David et al. [47] 52 4% 2% 2%<br />
no<br />
data<br />
ED,<br />
ICU,<br />
OR<br />
SURG<br />
no data MAL trocar PRE EP<br />
Misplacements:<br />
trocar technique 29%;<br />
blunt technique: 19%<br />
Complications: ED: 14%<br />
OP: 9%<br />
Ward: 25%<br />
(continued)
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 10: Complications when inserting a pleural drain - contd.<br />
Author N SC IP IA PE MF PS Technique Site QF Comments<br />
Demartines et al.<br />
[53]<br />
90 5.4% 0 0 0 18.9% * no data no data PRE EP<br />
Eddy et al. [59] 117 no data no data no data 5% no data no data no data ED SURG<br />
Etoch et al. [62] 599 no data no data no data 1.8% 9.8% * no data no data<br />
Heim et al. [75] 40 0 5% 0<br />
Helling et al. [76]<br />
Prehospital – Volume replacement 84<br />
no<br />
data<br />
45% * no data no data<br />
216 no data no data no data 3% no data MAL blunt<br />
Lechleutner et al.<br />
[88] 44 4.5% 4.5% 2.3% §<br />
no<br />
data<br />
ED,<br />
ICU<br />
etc.<br />
PRE,<br />
ED<br />
ER,<br />
OP,<br />
ICU<br />
SURG<br />
EDP<br />
NA, SURG<br />
no data<br />
no data MAL trocar PRE EP<br />
Mandal et al.<br />
[94] 5.474 no data no data no data 1.6% no data no data no data hospital no data<br />
Millikan et al.<br />
[107] 447 no data 0.25% 0.75% 2.4% no data MAL blunt ED<br />
Peters et al. [117]<br />
33 9% 21% # 3%<br />
no<br />
data<br />
SURG,<br />
EDP<br />
12% * no data no data PRE EP<br />
Complications:<br />
Surgeons: 6%<br />
ED physicians 13%<br />
Complications: ED: 37%<br />
OP/ICU: 34%<br />
(continued)
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 10: Complications when inserting a pleural drain - contd.<br />
Author N SC IP IA PE MF PS Technique Site QF Comments<br />
Schmidt et al.<br />
[125]<br />
Schöchl et al.<br />
[126]<br />
Sriussadaporn et<br />
al. [129]<br />
76 1.3% 0 0 0 5.2% * MAL blunt PRE<br />
111 2.7% 1% 1%<br />
Prehospital – Volume replacement 85<br />
no<br />
data<br />
NA<br />
(SURG)<br />
no data MAL trocar PRE EP<br />
42 no data no data no data 3% no data no data no data hospital no data<br />
* Additional pleural drain necessary; # possibly false CT interpretation; § in diaphragmatic rupture<br />
SC, subcutaneous misplacement; IP, intrapulmonary misplacement; IA, intraabdominal misplacement; PE, pleural empyema; MF, malfunction; PS, puncture site; QF,<br />
qualification of medical staff; PTX, pneumothorax; HTX, hemothorax; PRE, prehospital; ED, emergency department; ICU, intensive care unit; OP, operating room; EP,<br />
emergency physician; SURG, surgeon; EDP, emergency department physicians; MAL, mid to anterior axillary line; MCL, midclavicular line
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.5 Traumatic brain injury<br />
Interventions at the accident scene<br />
Vital functions<br />
Key recommendation:<br />
The goal in adults should be arterial normotension with a systolic blood<br />
pressure not below 90 mmHg.<br />
GoR B<br />
A fall in arterial oxygen saturation below 90% should be avoided. GoR B<br />
Explanation:<br />
Prospective randomized controlled trials, which examine the effect of hypertension and/or<br />
hypoxia on the treatment outcome, are certainly indefensible on ethical grounds. However, there<br />
are many retrospective studies [8, 25] which provide evidence of a markedly worse treatment<br />
outcome if hypotension or hypoxia is present. The absolute priority of diagnostic and treatment<br />
interventions at the accident scene is therefore to recognize and if possible immediately eliminate<br />
all conditions associated with a fall in blood pressure or reduction of oxygen saturation in the<br />
blood. Due to side effects, however, aggressive treatment to raise blood pressure and oxygen<br />
saturation has not always proved successful. The goals are normoxia, normocapnia, and<br />
normotension.<br />
Intubation is always considered for insufficient spontaneous breathing. However, it can also be<br />
considered in cases of unconsciousness with adequate spontaneous breathing. Unfortunately, the<br />
literature does not contain any high quality evidence on this to prove a clear benefit for the<br />
intervention. The main argument in favor of intubation is the efficient prevention of hypoxia.<br />
This is a threat in unconscious persons even with sufficient spontaneous breathing as the<br />
impaired protective reflexes can cause aspiration. The main argument against intubation is the<br />
hypoxic damage that can occur through misplaced intubation. During the development of the<br />
DGNC Guideline “Traumatic brain injury in adulthood” [6], which served as a model, there was<br />
consensus that there was overall benefit, and an A recommendation was thus given in this<br />
guideline. It was not possible to reach this consensus for the current polytrauma guideline.<br />
Interventions to ensure cardiovascular functions in multiply injured patients are described<br />
elsewhere in this guideline (see Chapter 1.3). Specific recommendations cannot be made for the<br />
infusion solution to be used in volume replacement in multiple injuries with concomitant<br />
traumatic brain injury [8].<br />
Prehospital – Traumatic brain injury 86
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Neurologic examination<br />
Key recommendation:<br />
Full consciousness, clouded consciousness or unconsciousness with pupil<br />
function and Glasgow Coma Scale must be recorded and documented at<br />
repeated intervals.<br />
Explanation:<br />
GoR A<br />
In the literature, the only clinical findings with a prognostic informative value are the presence of<br />
wide, fixed pupils [8, 23, 26] and a deterioration in the GCS score [8, 17, 23], both of which<br />
correlate with a poor treatment outcome. There are no prospective randomized controlled trials<br />
on using the clinical findings to guide the treatment. As such studies are definitely not ethically<br />
justifiable, the importance of the clinical examination was upgraded to a Grade of<br />
Recommendation A during the development of the guideline on the assumption, which cannot be<br />
confirmed at present, that the outcome can be improved by the earliest possible detection of lifethreatening<br />
conditions with corresponding therapeutic consequences.<br />
Despite various difficulties [2], the Glasgow coma scale (GCS) has established itself<br />
internationally as the assessment of the recorded severity at a given point in time of a brain<br />
function impairment. It enables the standardized assessment of the following aspects: eye<br />
opening, verbal response and motor response. The neurologic findings documented with time of<br />
day in the file are vital for the sequence of future treatment. Frequent checks of the neurologic<br />
finding must be carried out to detect any deterioration [8, 10].<br />
However, the use of the GCS on its own carries the risk of a diagnostic gap, particularly if only<br />
cumulative values are considered. This applies to the initial onset of apallic syndrome, which can<br />
become noticeable through spontaneous decerebrate rigidity which is not recorded on the GCS,<br />
and to concomitant injuries to the spinal cord. Motor functions of the extremities must therefore<br />
be recorded with separate lateral differentiation in arm and leg as to whether there is incomplete,<br />
complete or no paralysis. Attention should be paid here to the presence of decorticate or<br />
decerebrate rigidity. Providing no voluntary movements are possible, reaction to painful stimulus<br />
must be recorded on all extremities.<br />
If the patient is not unconscious, then orientation, cranial nerve function, coordination, and<br />
speech function must also be recorded.<br />
Prehospital – Traumatic brain injury 87
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Cerebral protection treatment<br />
Key recommendation:<br />
Glucocorticoids must not be administered. GoR A<br />
Explanation:<br />
According to the latest scientific knowledge, the goal of interventions to be taken at the accident<br />
scene is to achieve homeostasis (normoxia, normotension, prevention of hyperthermia) and<br />
prevention of threatening complications. The intention is to limit the extent of secondary brain<br />
damage and to provide those brain cells with functional impairment but which have not been<br />
destroyed with the best conditions for functional regeneration. This applies equally if multiple<br />
injuries are present.<br />
Up till now, there is no evidence from the data in the scientific literature of benefit being derived<br />
from more extensive treatment regimens viewed as specifically cerebral-protective. At present,<br />
no recommendation can be given on the prehospital administration of 21-aminosteroids, calcium<br />
antagonists, glutamate receptor antagonists or tris-(tris[hydroxy methyl]aminomethane) buffer<br />
[8, 11, 18, 29].<br />
Antiepileptic treatment prevents the incidence of epileptic seizures in the first week after trauma.<br />
However, the incidence of a seizure in the early phase does not lead to a worse clinical outcome<br />
[20, 25].<br />
The administration of glucocorticoids is no longer indicated due to a significantly increased 14day<br />
case fatality rate [1, 4] with no improvement in clinical outcome [5].<br />
Treatment for suspected severely elevated intracranial pressure<br />
Key recommendation:<br />
If severely elevated intracranial pressure is suspected, particularly with signs<br />
of transtentorial herniation (pupil widening, decerebrate rigidity, extensor<br />
reaction to painful stimulus, progressive clouded consciousness), the following<br />
treatments can be given:<br />
� Hyperventilation<br />
� Mannitol<br />
� Hypertonic saline solution<br />
GoR 0<br />
Prehospital – Traumatic brain injury 88
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Explanation:<br />
In cases of suspected transtentorial herniation and signs of apallic syndrome syndrome (pupil<br />
widening, decerebrate rigidity, extensor reaction to painful stimulus, progressive clouded<br />
consciousness), hyperventilation can be introduced as a treatment option in the early phase after<br />
trauma [8, 25]. The guide values are 20 breaths/min in adults. However, hyperventilation, which<br />
used to be used because of its often impressive effect in reducing intracranial pressure, also<br />
causes reduced cerebral perfusion because of the induced vasoconstriction. With aggressive<br />
hyperventilation, this involves the risk of cerebral ischemia and thus deterioration in clinical<br />
outcome [25].<br />
The administration of mannitol can lower intracranial pressure [ICP] for a short time (up to 1<br />
hour) [25]. It can also be given without measuring ICP if transtentorial herniation is suspected.<br />
Up till now, there has been only scant evidence of the cerebral-protective effect of hypertonic<br />
saline solutions. Mortality appears to be somewhat less compared to mannitol. However, this<br />
conclusion is based on a small number of cases and is statistically not significant [28].<br />
There is insufficient evidence [19] for the administration of barbiturates, which was<br />
recommended in previous guidelines for intracranial pressure crises not controllable by other<br />
means [23]. When administering barbiturates, attention must be paid to the negative inotropic<br />
effect, possible fall in blood pressure, and impaired neurologic assessment.<br />
Transport<br />
Key recommendation:<br />
In the case of penetrating injuries, the penetrating object should be left in situ;<br />
in certain circumstances it must be detached.<br />
Explanation:<br />
GoR B<br />
It is essential that multiply injured persons with symptoms of concomitant traumatic brain injury<br />
are admitted to a hospital with adequate treatment facilities. In the case of a traumatic brain<br />
injury with sustained unconsciousness (GCS ≤ 8), increasing cloudiness (deterioration in<br />
individual GCS scores), pupillary disorder, paralysis or seizures, the hospital should definitely<br />
have provision for neurosurgical management of intracranial injuries [8].<br />
No clear recommendation can be given on analgesic sedation and relaxants for transportation as<br />
there is a lack of studies with evidence of a positive effect on traumatic brain injury. With these<br />
interventions, cardiopulmonary management is definitely easier to guarantee so that the decision<br />
on this must be left to the judgment of the treating emergency physician. The disadvantage of<br />
these interventions is a more or less severe limitation on the ability to make a neurologic<br />
assessment [23].<br />
Prehospital – Traumatic brain injury 89
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
In the case of penetrating injuries, the penetrating object should be left in situ; in certain<br />
circumstances it must be detached. Injured intracranial vessels are often compressed by the<br />
foreign body so that removing it encourages the development of intracranial bleeding. Removal<br />
must therefore be carried out under surgical conditions with the possibility of hemostasis in the<br />
injured brain tissue. Even if there are no prospective randomized controlled trials on the<br />
optimum procedure for penetrating injuries, this procedure makes sense from a pathophysiologic<br />
viewpoint.<br />
The possibility of a concomitant unstable spine fracture should be considered during<br />
transportation, and the patient should be appropriately positioned (see Chapter 1.6).<br />
Prehospital – Traumatic brain injury 90
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Alderson P, Roberts I. Corticosteroids for acute<br />
traumatic brain injury. The Cochrane Database of<br />
Systematic Reviews 2005, Issue 1.<br />
2. Balestreri M, Czosnyka M, Chatfield DA, Steiner LA,<br />
Schmidt EA, Smielewski P, Matta B, Pickard JD:<br />
Predictive value of Glasgow Coma Scale after brain<br />
trauma: change in trend over the past ten years. J<br />
Neurol Neurosurg Psychiatry 75:161-162, 2004.<br />
3. Brihaye J, Frowein RA, Lindgren S, Loew F,<br />
Stroobandt G. Report on the meeting of the WFNS<br />
Neuro-Traumatology Committee. Brussels. I. Coma<br />
scaling. Acta Neurochir (Wien) 40: 181-186, 1978<br />
4. CRASH trial collaborators. Effect of intravenous<br />
corticosteroids on death within 14 days in 10008 adults<br />
with clinically significant head injury (MRC CRASH<br />
trial): randomised placebo-controlled trial. Lancet<br />
364:1321 – 28, 2004.<br />
5. CRASH trial collaborators. Final results of MRC<br />
CRASH, a randomised placebo-controlled trial of<br />
intravenous corticosteroid in adults with head injury -<br />
outcomes at 6 months. Lancet 365: 1957–59, 2005<br />
[LoE 1b].<br />
6. Firsching R, Messing-Jünger M, Rickels E, Gräber S<br />
und Schwerdtfeger K. Leitlinie Schädelhirntrauma im<br />
Erwachsenenalter der Deutschen Gesellschaft für<br />
Neurochirurgie. AWMF online 2007. http://www.uniduesseldorf.de/AWMF/ll/008-001.htm.<br />
7. Frowein RA. Classification of coma. Acta Neurochir<br />
34: 5-10, 1976<br />
8. Gabriel EJ, Ghajar J, Jagoda A, Pons PT, Scalea T,<br />
Walters BC; Brain Trauma Foundation. Guidelines for<br />
prehospital management of traumatic brain injury. J<br />
Neurotrauma. 19:111-74, 2002 [Evidenzbasierte<br />
Leitlinie]<br />
9. Gurdjian ES, Brihaye J, Christensen JC, Frowein RA,<br />
Lindgren S, Luyendijk W, Norlen G, Ommaya AK,<br />
Prescu I, de Vasconcellos Marques A, Vigouroux RP.<br />
Glossary of Neurotraumatology. Acta Neurochir<br />
(Wien) Suppl. 25. Springer, Wien, New York, 1979<br />
10. Karimi A, Burchardi H, Deutsche Interdisziplinäre<br />
Vereinigung für Intensiv- und Notfallmedizin (DIVI)<br />
Stellungnahmen, Empfehlungen zu Problemen der<br />
Intensiv- und Notfallmedizin, 5. Auflage. Köln,<br />
asmuth druck + crossmedia. 2004.<br />
11. Langham J, Goldfrad C, Teasdale G, Shaw D, Rowan<br />
K. Calcium channel blockers for acute traumatic brain<br />
injury (Cochrane Review). In: The Cochrane Library,<br />
Issue 1, 2004. Chichester, UK: John Wiley & Sons,<br />
Ltd.<br />
12. Lorenz, R. Neurotraumatologie. Standartisierte<br />
Nomenklatur. Berlin, Springer 1990<br />
13. Kraus JF, Black MA, Hessol N, Ley P, Rokaw W,<br />
Sullivan C, Bowers S, Knowlton S, Marshall L. The<br />
incidence of acute brain injury and serious impairment<br />
in a defined population. Am J Epidemiol. 1984<br />
Feb;119(2):186-201.<br />
14. Kraus JF, Fife D and Conroy C. Incidence, Severity,<br />
and Outcomes of Brain Injuries Involving Bicycles<br />
Am J Public Health 1987; 77:76-78.<br />
15. Maas, A. et al.: EBIC-Guidelines for mangement of<br />
severe head injury in adults. Acta Neurchir. (Wien)<br />
139, 286-294, 1997 [Evidenzbasierte Leitlinie]<br />
16. Marion DW and Carlier PM. Problems with initial<br />
Glasgow Coma Scale assessment caused by<br />
prehospital treatment of patients with head injuries:<br />
results of a national survey. J Trauma. 1994, 36(1):89-<br />
95.<br />
17. Marmarou A, Lu J, Butcher I, McHugh GS, Murray<br />
GD, Steyerberg EW, Mushkudiani NA, Choi S, Maas<br />
AI. Prognostic value of the Glasgow Coma Scale and<br />
pupil reactivity in traumatic brain injury assessed<br />
pre‐hospital and on enrollment: an IMPACT analysis.<br />
J Neurotrauma. 2007; 24(2):270-80 [LoE 3a].<br />
18. Roberts I Aminosteroids for acute traumatic brain<br />
injury (Cochrane Review). In: The Cochrane Library,<br />
Issue 1, Chichester, UK: John Wiley & Sons, Ltd.<br />
2004<br />
19. Roberts I. Barbiturates for acute traumatic brain injury<br />
(Cochrane Review). In: The Cochrane Library, Issue 1,<br />
2004. Chichester, UK: John Wiley & Sons, Ltd.<br />
20. Schierhout G, Roberts I. Anti-epileptic drugs for<br />
preventing seizures following acute traumatic brain<br />
injury (Cochrane Review). In: The Cochrane Library,<br />
Issue 1, 2004. Chichester, UK: John Wiley & Sons,<br />
Ltd.<br />
21. Teasdale G, Jennett B. Assessment of coma and<br />
impaired consiousness. Lancet 2 81-84, 1974.<br />
22. Teasdale G, Jennett B: Assessment and prognosis of<br />
coma after head injury. Acta Neurochir (Wien) 34: 45-<br />
55, 1976.<br />
23. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care.<br />
Management and Prognosis of Severe Traumatic Brain<br />
Injury. 2000<br />
http://www2.braintrauma.org/guidelines/downloads/btf<br />
_guidelines_management.pdf [Evidenzbasierte<br />
Leitlinie]<br />
24. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care.<br />
Management and Prognosis of Severe Traumatic Brain<br />
Injury. Update 2003<br />
http://www2.braintrauma.org/guidelines/downloads/btf<br />
_guidelines_cpp_u1.pdf [Evidenzbasierte Leitlinie]<br />
25. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care. Guidelines<br />
for the Management of Severe Traumatic Brain Injury.<br />
3rd Edition.<br />
http://braintrauma.org/guidelines/downloads/JON_24_<br />
Supp1.pdf [Evidenzbasierte Leitlinie]<br />
26. Tien HC, Cunha JR, Wu SN, Chughtai T, Tremblay<br />
LN, Brenneman FD, Rizoli SB. Do trauma patients<br />
with a Glasgow Coma Scale score of 3 and bilateral<br />
Prehospital – Traumatic brain injury 91
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
fixed and dilated pupils have any chance of survival? J<br />
Trauma. 2006; 60(2):274-8 [LoE 3b].<br />
27. Tönnis W, Loew F. Einteilung der gedeckten<br />
Hirnschädigungen. Ärztliche Praxis 5: 13-14, 1953<br />
28. Wakai A, Roberts IG, Schierhout G. Mannitol for<br />
acute traumatic brain injury. Cochrane Database of<br />
Systematic Reviews 2007, Issue 1 [LoE 3b].<br />
29. Willis C, Lybrand S, Bellamy N. Excitatory amino<br />
acid inhibitors for traumatic brain injury (Cochrane<br />
Review). In: The Cochrane Library, Issue 1, 2004.<br />
Chichester, UK: John Wiley & Sons, Ltd.<br />
Prehospital – Traumatic brain injury 92
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.6 Spine<br />
When should a spinal injury be assumed?<br />
What diagnostic procedures are required?<br />
Key recommendation:<br />
A thorough physical examination including the spine and the functions<br />
associated with it must be carried out.<br />
Explanation:<br />
GoR A<br />
A physical examination of the patient is the basic requirement for making a diagnosis which, in<br />
turn, is the prerequisite for subsequent treatment interventions.<br />
After the vital functions have been monitored and secured, the initial examination of a<br />
responsive patient’s spine in the emergency situation at the accident scene involves the<br />
exploratory neurologic assessment of sensitivity and motor functions. A segmental neurologic<br />
deficit indicates the presence of a spinal cord injury. The level and complete/incomplete lesions<br />
can be measured to a limited extent. An absence of back pain is not a definite sign that there can<br />
be no relevant injury to the thoracic or lumbar spine [28].<br />
To complete the initial examination, the cervical spine and the entire back are inspected (for<br />
signs of injury, deformities) and felt (tenderness, percussion tenderness, steps, displacements,<br />
palpable gaps between spinous processes).<br />
Assessing the mechanism of injury can provide clues on the probability of a spinal injury [20].<br />
Even if there are no scientific studies on the importance and the necessary scope of the physical<br />
examination in the prehospital emergency examination, it is still an indispensable requirement<br />
for detecting symptoms and making (suspected) diagnoses. All the above-mentioned<br />
examinations are used to detect relevant, threatening or potentially threatening disorders and<br />
injuries, which altogether can make it necessary to administer immediate and specific treatment<br />
or make a logistic decision on the spot [2, 17].<br />
The circulation parameters, blood pressure and pulse, should be measured more than once at<br />
least during the course (depending on finding, overall situation and timeframe). These are<br />
dynamic values, which are indicators for the occurrence of neurogenic shock.<br />
Various scoring systems do not permit a clear statement but combining several scores increases<br />
the probability of success [63].<br />
Which concomitant injuries make the presence of spinal injury likely?<br />
Key recommendation:<br />
Prehospital – Spine 93
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The presence of a spinal injury must be assumed in unconscious patients until<br />
evidence to the contrary is found.<br />
Explanation:<br />
GoR A<br />
The coincidence of spinal injuries and certain other injury patterns is increased. These are purely<br />
statistical probabilities.<br />
How is the diagnosis for unstable spinal injury made and how definite is it?<br />
Key recommendation:<br />
If the following 5 criteria are absent, it can be assumed that no unstable spinal<br />
injury is present:<br />
� impaired consciousness<br />
� neurologic deficit<br />
� spinal pain or myogelosis<br />
� intoxication<br />
� trauma in the extremities<br />
Explanation:<br />
GoR A<br />
Several groups have developed clinical decision rules to simplify prehospital patient<br />
transportation and to set sensible limits to the radiologic primary diagnostic study after blunt<br />
trauma to the spine. Some of these decision rules relate to the prehospital situation [23, 24, 45]<br />
whereas others relate to the emergency department [9, 33, 35, 36, 56]. Whereas some studies<br />
examine the whole spine, others limit themselves to the cervical (C) or thoracic/lumbar spine<br />
(T/L).<br />
The results of these studies correspond [9] to the maximum extent so that we can primarily rely<br />
hereinafter on the prospectively validated criteria of Domeier et al. and Muhr et al. [24, 25].<br />
Smaller studies have concentrated solely on multiply injured patients [53] but find similar<br />
predictors so that it appears justified to generalize the results. On other hand, Muhr et al. and<br />
Holmes et al. regarded the presence of other relevant injuries as a criterion that made the definite<br />
exclusion of a spinal injury more difficult or impossible. A retrospective study of patients with<br />
thoracolumbar spinal injuries found that the presence of concomitant injuries lowered the<br />
frequency of (pressure) pain in the back from over 90% to 64% [43]. However, one can assume<br />
from this that multiply injured patients have either an extremity fracture or impaired<br />
consciousness so that, depending on the decision rules, a suspected spinal injury cannot be ruled<br />
out.<br />
Prehospital – Spine 94
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Taking into consideration the 5 criteria of impaired consciousness, neurologic deficit, spinal pain<br />
or myogelosis, intoxication, and trauma in the extremities, Domeier et al. missed only 2 relevant<br />
spinal injuries [24]. In addition, there were 13 stable spinal injuries that did not require<br />
osteosynthesis thus yielding a sensitivity of 95% with a negative predictor value of 99.5%. The<br />
study related to the whole spine and found approximately 100 fractures each in the cervical,<br />
thoracic, and lumbar spine.<br />
Rotation injuries (type C according to AO) are relatively unstable and have an increased risk of<br />
further neurologic deterioration [32]. If a rotation injury is suspected on the basis of the<br />
mechanism of injury, immobilization should be carried out carefully and without delay on<br />
account of the instability.<br />
How is the diagnosis for spinal injury without spinal cord involvement made and how<br />
definite is it?<br />
Key recommendation:<br />
Acute pain in the spinal region after trauma should be assessed as an<br />
indication of a spinal injury.<br />
Explanation:<br />
GoR B<br />
The cited injury signs may be present both in a bony spinal injury and in a solely soft tissue<br />
injury surrounding the bone. There are no prehospital findings that can be collected which can<br />
prove or exclude a spinal injury with certainty. External injury signs - deformations, tenderness,<br />
percussion tenderness, steps, lateral displacements, palpable gaps between spinous processes -<br />
are indirect clues to the presence of an injury to the spine. An evaluation of the (positioning)<br />
stability of the injury cannot be made in the prehospital phase.<br />
How is the diagnosis for spinal injury with spinal cord involvement made and how definite<br />
is it?<br />
Explanation:<br />
The neurologic deficit in sensitivity and/or motor functions is definitive in the diagnosis of<br />
damage to the spinal cord. It is highly probable that a bony injury to the spine is also present in<br />
adults. Neurologic deficits without bony involvement can occur more frequently in children<br />
(SCIWORA [Spinal Cord Injury Without Radiographic Abnormality] syndrome) [7].<br />
The level and complete/incomplete lesions can only be measured to a limited extent. It is<br />
therefore not possible to make a conclusive statement on the prognosis of the injury at the<br />
accident scene.<br />
On the other hand, a normal neurology finding does not exclude a spinal injury with spinal cord<br />
involvement.<br />
Prehospital – Spine 95
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
How is a spinal injury treated in the prehospital phase?<br />
What is the technical rescue procedure for a person with a spinal injury?<br />
Key recommendations:<br />
In the event of acute threat to life (e.g., fire/danger of explosion), which can<br />
only be eliminated by immediate rescue from the danger zone, immediate,<br />
direct rescue from the danger zone must be effected even if a spinal injury is<br />
suspected, if necessary even disregarding precautionary measures for the<br />
injured person.<br />
GoR A<br />
The cervical spine must be immobilized before technical rescue. GoR A<br />
Explanation:<br />
The first prehospital procedure for a casualty is to immobilize the cervical spine using a cervical<br />
collar. To date, however, we are not aware of any literature that confirms this procedure in<br />
preventing secondary damage during the technical rescue. No differences in the use of different<br />
immobilization collars have been found [18, 51].<br />
During the rescue of an injured person, all non-physiologic spine movements, particularly<br />
flexion, segmental rotation and lateral inclination, must be avoided. The spine must be moved<br />
into its neutral position, i.e. flat supine position, in a coordinated way with enough assistants [6].<br />
With due consideration of the time required, a more extended technical rescue - e.g., involving<br />
removal of a car roof - should be considered. Aids such as the scoop stretcher or spine boards<br />
make it easier to rescue a person with a spinal injury in the above-mentioned neutral position<br />
from a difficult accident scene.<br />
How is a person with a spinal injury positioned/immobilized?<br />
Explanation:<br />
Up till now, the first prehospital procedure for a casualty is the immobilization of the cervical<br />
spine using a cervical collar, even if the evidence level for this is not high. The cervical spine is<br />
thereby put into the neutral position. If this causes pain or an increase in neurologic deficit, do<br />
not reposition in the neutral position.<br />
In a prospective study, Bandiera and Stiell found evidence that clinically significant injuries<br />
could be detected with a sensitivity of 100% using the Canadian C-spine rule [56]. However, a<br />
proviso should be added here that this study was conducted in hospital on fully conscious<br />
patients [5]. Thus, a relatively long period of time has already elapsed since the accident and, at<br />
this later point in time, the symptoms of milder acceleration injuries to the cervical spine also<br />
manifest themselves for the first time; these may not occur at the accident scene due to the<br />
psychologic impairment.<br />
Prehospital – Spine 96
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
When there is a traumatic brain injury and a suspected cervical spine injury, it should be weighed<br />
up whether to fit a rigid cervical collar or whether another type of immobilization (e.g., only a<br />
vacuum mattress) is possible in order to prevent a potential increase in ICP [21, 22, 37, 38, 39,<br />
50]. In another clinical study, there was no evidence of an increase in ICP if the rigid cervical<br />
collar was fitted correctly [39]. So, when a rigid cervical collar is being fitted on a patient with a<br />
TBI, care should be taken that it is the correct size and not too tightly fastened so that the<br />
possibility of any venous outflow obstruction is excluded. In addition, the upper part of the body<br />
should be elevated if possible in this situation.<br />
The above-mentioned position can also be immobilized on the vacuum mattress. This achieves<br />
the currently most effective immobilization of the whole spine as well. If the head is also<br />
enclosed with high cushions or belts, this further restricts possible residual movement of the<br />
cervical spine. To date, there is no randomized study that provides evidence of a positive effect<br />
from immobilizing the spine [40].<br />
A patient carry sheet on the vacuum mattress makes subsequent re-positioning in hospital easier<br />
[8]. Other aids such as the scoop stretcher or spine boards can only immobilize the spine to a<br />
limited extent.<br />
Prehospital – Spine 97
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
How is a person with a spinal injury transported?<br />
Key recommendation:<br />
Transport should be as gentle as possible and free of pain. GoR B<br />
Explanation:<br />
A patient with a spinal injury should be transported as gently as possible, i.e. without further<br />
external force to avoid pain and possible secondary damage. After positioning and strapping in,<br />
analgesics are administered during transportation. A helicopter offers the smoothest form of<br />
transport. In addition, it might offer a time advantage when a patient with a spinal injury and<br />
neurologic deficits has to be transported to a center.<br />
Is there a specific treatment for spinal injury in the prehospital phase?<br />
Explanation:<br />
The benefit of a high dose of cortisone treatment being administered prehospital (or<br />
subsequently) for spinal injuries with neurologic deficit is controversial [65]. Following the<br />
successful administration of corticosteroids for spinal trauma in many animal experiments [1, 25,<br />
26, 58, 59, 66], it has not been possible to confirm the results in all clinical studies. Criticism has<br />
been leveled at the NASCIS (National Acute Spinal Cord Injury Studies) several times [19], for<br />
instance, the lack of effect in the NASCIS I study (there was no control group here but low-dose<br />
cortisone was compared with too little high-dose cortisone) and the lack of placebo group in the<br />
NASCIS III study as well [19]. The positive effects in the NASCIS II study were only minor, of<br />
limited clinical relevance, and less marked after 1 year than after 6 months.<br />
Here is a summary of the advantages and disadvantages of giving methylprednisolone according<br />
to current literature:<br />
Reasons for cortisone treatment:<br />
1. The NASCIS II study showed an improvement in motor outcome providing methyl<br />
prednisolone treatment was started within 8 hours [11, 12]. However, this outcome was<br />
only unilaterally verified and dependent on the researcher.<br />
2. Other studies of worse methodological quality have also found a benefit from cortisone<br />
treatment but in this case the start of treatment was predominantly evaluated after<br />
admission to hospital.<br />
3. The NASCIS III study showed a greater effect in treatment duration of 48 hours<br />
providing treatment commenced between 3 and 8 hours after trauma [14, 15].<br />
4. Relevant side effects such as abdominal bleeding are not increased [27] and there has<br />
been no evidence of accumulation of femoral head necroses following high-dose<br />
cortisone treatment [64].<br />
Prehospital – Spine 98
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
5. There is no other definitive pharmacologic treatment for spinal cord injury.<br />
Reasons against cortisone treatment:<br />
1. No relevant benefit could be found in the NASCIS I study [13].<br />
2. The proven benefit was only found in patients who had received treatment within 8<br />
hours.<br />
3. The proven benefit was small, of unconfirmed clinical significance, and even smaller<br />
after 1 year than after 6 months [10, 12].<br />
4. There was no placebo control group in the NASCIS III study [14, 15].<br />
5. Further studies showed a higher complication rate in the patients treated with cortisone<br />
(increase in lung complications [29, 31], particularly in elderly patients [42], and<br />
gastrointestinal bleeding [48]).<br />
6. Lack of neurologic benefit in other studies with frequently unclear injury pattern [30, 42,<br />
48, 49].<br />
Infusion treatment to stabilize the circulation is necessary in neurogenic shock with due<br />
consideration being paid to other possible sources of bleeding caused by injury. The infusion<br />
volume to be administered and the target mean arterial pressure is also disputed by expert<br />
opinion. Adequate analgesic treatment is necessary to prevent shock.<br />
Extreme pulling forces on the cervical spine, e.g., when removing a motorbike helmet, and<br />
segmental torsions on unstable C injuries (cervical vertebrae) of the spine can lead to<br />
deterioriation in the neurologic deficit by directly affecting the spinal cord. It should be noted<br />
here that there are no references to secondary damage in the literature on this either.<br />
Prehospital – Spine 99
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Are there advantages for the patient with spinal injury in being transported primarily to a<br />
trauma center with a spine surgery facility?<br />
Key recommendation:<br />
Patients with neurologic deficits and suspected spinal injury should be<br />
transported primarily and as a minimum to a regional trauma center with a<br />
spine surgery facility.<br />
Explanation:<br />
GoR B<br />
Early surgery on spinal injuries with spinal cord involvement can improve the neurologic<br />
outcome [44, 52].<br />
Early surgery (within 72 hours) on cervical spine injuries with neurologic deficits does not<br />
conceal an increased risk of additional complications [44].<br />
For this reason, particularly in the case of isolated spinal trauma and a non-acute threat to life,<br />
management should, if possible, be in a spinal center [60]. Patients with a spinal canal<br />
constriction, particularly in the cervical region, appear to gain from early surgery [4]. Even if<br />
there is only little evidence, it should still be assumed that patients with incomplete neurology<br />
and partial displacement of the spinal canal could gain from early reduction and, if necessary,<br />
surgical debridement.<br />
Summary:<br />
The vast majority of the screened literature relates mainly to the hospital situation, in other<br />
words, to studies which were conducted after admission to hospital. Provided they are relevant,<br />
these data must be extrapolated to the prehospital situation. There is a relatively large number of<br />
studies which were conducted in the USA and thus in the paramedic system. This initial<br />
management at the accident scene is only partially comparable with the German rescue and<br />
emergency physician system.<br />
These two points must be taken into account as this means that conclusions (in terms of a<br />
guideline) have only restricted validity on applicability to the prehospital emergency physician<br />
situation in Germany.<br />
Prehospital – Spine 100
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Amar PA, Levy ML (1999) Pathogenesis and<br />
pharmacological strategies for mitigatin secondary<br />
damage in acute spinal cord injury. Neurosurgery<br />
44:1027-1040<br />
2. American, College, of, Surgeons (1997) Advanced<br />
Trauma Life Support (Chicago)<br />
3. Asamoto S, Sugiyama H, Iida M, Doi H, Itoh T,<br />
Nagao T, Hayashi M, Matsumoto K, Morii M (2001)<br />
Trauma sites and clinical features associated with<br />
acute hyperextension spinal cord injury without bone<br />
damage--relationship between trauma site and<br />
severity. Neurol Med Chir (Tokyo) 41(1):1-6;<br />
discussion 6-7.<br />
4. Asazuma T, Satomi K, Suzuki N, Fujimura Y,<br />
Hirabayashi K (1996) Management of patients with an<br />
incomplete cervical spinal cord injury. Spinal Cord<br />
34(10):620-625.<br />
5. Bandiera G, Stiell IG, Wells GA, Clement CM, De<br />
Maio VJ, Vandemheen KL (2003) The Canadian Cspine<br />
Rule Performs Better Than Unstructured<br />
Physician Judgment. Ann Emerg Med 42:395-402<br />
6. Beck A, Krischak G, Bischoff M (2009)<br />
Wirbelsäulenverletzungen und spinales Trauma.<br />
Notfall & Rettungsmedizin 12(6):469-479<br />
7. Beck A, Gebhard F, Kinzl L, Rüter A, Hartwig E<br />
(2000) Spinal cord injury without radiographic<br />
abnormalities in children and adolescents. Knee Surg,<br />
Sports Traumatol, Arthrosc 8(3):186-189<br />
8. Beck A, Gebhard F, Kinzl L, Strecker W (2001)<br />
Prinzipien und Techniken der unfallchirurgischen<br />
Erstversorgung am Einsatzort. Unfallchirurg<br />
104(11):1082-1099<br />
9. Blackmore C, Emerson S, Mann F, Koepsell TD<br />
(1999) Cervical spine imaging in patients with<br />
trauma: Determination of fracture risk to optimize use.<br />
Radiology 211(3):759-766<br />
10. Bracken MB, Holford TR (1993) Effects of timing of<br />
methylprednisolone or naloxone administration on<br />
recovery of segmental and long-tract neurological<br />
function in NASCIS 2. J Neurosurg 79(4):500-507.<br />
11. Bracken MB, Shepard MJ, Collins WF, Holford TR,<br />
Young W, Baskin DS, Eisenberg HM, Flamm E, Leo-<br />
Summers L, Maroon J, et al. (1990) A randomized,<br />
controlled trial of methylprednisolone or naloxone in<br />
the treatment of acute spinal-cord injury. Results of<br />
the Second National Acute Spinal Cord Injury Study.<br />
N Engl J Med 322(20):1405-1411.<br />
12. Bracken MB, Shepard MJ, Collins WF, Jr., Holford<br />
TR, Baskin DS, Eisenberg HM, Flamm E, Leo-<br />
Summers L, Maroon JC, Marshall LF, et al. (1992)<br />
Methylprednisolone or naloxone treatment after acute<br />
spinal cord injury: 1-year follow-up data. Results of<br />
the second National Acute Spinal Cord Injury Study. J<br />
Neurosurg 76(1):23-31.<br />
13. Bracken MB, Shepard MJ, Hellenbrand KG, Collins<br />
WF, Leo LS, Freeman DF, Wagner FC, Flamm ES,<br />
Eisenberg HM, Goodman JH, et al. (1985)<br />
Methylprednisolone and neurological function 1 year<br />
after spinal cord injury. Results of the National Acute<br />
Spinal Cord Injury Study. J Neurosurg 63(5):704-713.<br />
14. Bracken MB, Shepard MJ, Holford TR, Leo-Summers<br />
L, Aldrich EF, Fazl M, Fehlings M, Herr DL, Hitchon<br />
PW, Marshall LF, Nockels RP, Pascale V, Perot PL,<br />
Jr., Piepmeier J, Sonntag VK, Wagner F, Wilberger<br />
JE, Winn HR, Young W (1997) Administration of<br />
methylprednisolone for 24 or 48 hours or tirilazad<br />
mesylate for 48 hours in the treatment of acute spinal<br />
cord injury. Results of the Third National Acute<br />
Spinal Cord Injury Randomized Controlled Trial.<br />
National Acute Spinal Cord Injury Study. JAMA<br />
277(20):1597-1604.<br />
15. Bracken MB, Shepard MJ, Holford TR, Leo-Summers<br />
L, Aldrich EF, Fazl M, Fehlings MG, Herr DL,<br />
Hitchon PW, Marshall LF, Nockels RP, Pascale V,<br />
Perot PL, Jr., Piepmeier J, Sonntag VK, Wagner F,<br />
Wilberger JE, Winn HR, Young W (1998)<br />
Methylprednisolone or tirilazad mesylate<br />
administration after acute spinal cord injury: 1-year<br />
follow up. Results of the third National Acute Spinal<br />
Cord Injury randomized controlled trial. J Neurosurg<br />
89(5):699-706.<br />
16. Chandler DR, Nemejc C, Adkins RH, Waters RL<br />
(1992) Emergency cervical-spine immobilization.<br />
Ann Emerg Med 21(10):1185-1188.<br />
17. Chen XY, Carp JS, Chen L, Wolpaw JR (2002)<br />
Corticospinal tract transection prevents operantly<br />
conditioned H-reflex increase in rats. Exp Brain Res<br />
144(1):88-94<br />
18. Cline JR, Scheidel E, Bigsby EF (1985) A comparison<br />
of methods of cervical immobilization used in patent<br />
extrication and transport. J Trauma 25(7):649-653<br />
19. Coleman WP, Benzel D, Cahill DW, Ducker T,<br />
Geisler F, Green B, Gropper MR, Goffin J, Madsen<br />
PW, 3rd, Maiman DJ, Ondra SL, Rosner M, Sasso<br />
RC, Trost GR, Zeidman S (2000) A critical appraisal<br />
of the reporting of the National Acute Spinal Cord<br />
Injury Studies (II and III) of methylprednisolone in<br />
acute spinal cord injury. J Spinal Disord 13(3):185-<br />
199.<br />
20. Cooper C, Dunham CM, Rodriguez A (1995) Falls<br />
and major injuries are risk factors for thoracolumbar<br />
fractures: cognitive impairment and multiple injuries<br />
impede the detection of back pain and tenderness. J<br />
Trauma 38:692-696<br />
21. Craig G, Nielsen MS (1991) Rigid cervical collars and<br />
intracranial pressure. Intensive Care Med 17:504-505<br />
22. Davies G, Deakin c, Wilson A (1996) The effects of a<br />
rigid collar on intracranial pressure. Injury 27:647-649<br />
23. Domeier RM, Evans RW, Swor RA, Rivera-Rivera<br />
EJ, Frederiksen SM (1997) Prospective validation of<br />
out-of-hospital spinal clearance criteria: a preliminary<br />
report. Acad Emerg Med 4(6):643-646 [LoE 1a]<br />
24. Domeier RM, Swor RA, Evans RW, Hancock JB,<br />
Fales W, Krohmer J, Frederiksen SM, Rivera-Rivera<br />
EJ, Schork MA (2002) Multicenter prospective<br />
validation of prehospital clinical spinal clearance<br />
criteria. J Trauma 53(4):744-750<br />
25. Ducker TB (1990) Treatment of spinal-cord injury. N<br />
Engl J Med 322(20):1459-1461.<br />
Prehospital – Spine 101
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
26. Ducker TB, Zeidman SM (1994) Spinal cord injury:<br />
Role of steroid therapy. Spine 19:2281-2287<br />
27. Epstein N, Hood DC, Ransohoff J (1981)<br />
Gastrointestinal bleeding in patients with spinal cord<br />
trauma. Effects of steroids, cimetidine, and mini-dose<br />
heparin. J Neurosurg 54(1):16-20.<br />
28. Frankel H, Rozycki G, Ochsner MG, Harviel JD,<br />
Champion HR (1994) Indication for obtaining<br />
surveillance thoracic and lumbar spine radiographs. J<br />
Trauma 37(4):673-676<br />
29. Galandiuk S, Raque G, Appel S, Polk HCj (1993) The<br />
two-edged sword of large-dose steroids for spinal cord<br />
trauma. Ann Surg 218:419-427<br />
30. George ER, Scholten DJ, Buechler CM, Jordan-Tibbs<br />
J, Mattice C, Albrecht RM (1995) Failure of<br />
methylprednisolone to improve the outcome of spinal<br />
cord injuries. Am Surg 61:659-664<br />
31. Gerndt SJ, Rodriguez JL, Pawlik JW, Taheri PA,<br />
Wahl WL, Michaels AJ, Papadopoulos SM (1997)<br />
Consequences of high-dose steroid therapy for acute<br />
spinal cord injury. J Trauma 42:279-284<br />
32. Gertzbein SD (1994) Neurologic deterioration in<br />
patients with thoracic and lumbar fractures after<br />
admission to the hospital. Spine 19(15):1723-1725.<br />
33. Hanson JA, Blackmore CC, Mann FA, Wilson AJ<br />
(2000) Cervical spine injury: a clinical decision rule to<br />
identify high-risk patients for helical CT screening.<br />
AJR Am J Roentgenol 174(3):713-717<br />
34. Ho AM-H, Fung KY, M. JG, K. KM, P<strong>eng</strong> Z (2002)<br />
Rigid Cervical Collar and Intracranial Pressure of<br />
Patients with Severe Head Injury. J Trauma<br />
53(6):1185-1188<br />
35. Hoffman JR, Mower WR, Wolfson AB, Todd KH,<br />
Zucker MI (2000) Validity of a set of clinical criteria<br />
to rule out injury to the cervical spine in patients with<br />
blunt trauma. National Emergency X-Radiography<br />
Utilization Study Group. New Engl J Med 343(2):94-<br />
99<br />
36. Holmes JF, Panacek EA, Miller PQ, Lapidis AD,<br />
Mower WR (2003) Prospective evaluation of criteria<br />
for obtaining thoraxolumbar radiographs in trauma<br />
patients. J Emerg Med 24(1):1-7<br />
37. Hunt K, Hallworth S, Smith M (2001) The effects of<br />
rigid collar placement on intracranial and cerebral<br />
perfussion pressures. Anaesthesia 56:511-513<br />
38. Kolb JC, Summers RL, Galli RL (1999) Cervical<br />
collar-induced changes in intracranial pressure. Am J<br />
Emerg Med 17:135-137<br />
39. Kuhnigk H, Bomke S, Sefrin P (1993) [Effect of<br />
external cervical spine immobilization on intracranial<br />
pressure]. Aktuelle Traumatol 23(8):350-353.<br />
40. Kwan I, Bunn F, Roberts I, Committee obotWP-HTCs<br />
(2001) Spinal immobilisation for trauma patients<br />
(Cochrane Review). The Cochrane Library Issue<br />
4):Update Software<br />
41. Lam AM (1992) Spinal Cord Injury: Management.<br />
Curr Opin Anesth 5:632-639<br />
42. Matsumoto T, Tamaki T, Kawakami M, Yoshida M,<br />
Ando M, Yamada H (2001) Early complications of<br />
high-dose methylprednisolone sodium succinate<br />
treatment in the follow-up of acute cervical spinal<br />
cord injury. Spine 26(4):426-430.<br />
43. Meldon SW, Moettus LN (1995) Thoracolumbar<br />
spine fractures: clinical presentation and the effect of<br />
altered sensorium and major injury. J Trauma<br />
39(6):1110-1114 [LoE 4]<br />
44. Mirza SK, Kr<strong>eng</strong>el WF, 3rd, Chapman JR, Anderson<br />
PA, Bailey JC, Grady MS, Yuan HA (1999) Early<br />
versus delayed surgery for acute cervical spinal cord<br />
injury. Clin Orthop 359:104-114 [LoE 4]<br />
45. Muhr MD, Seabrook DL, Wittwer LK (1999)<br />
Paramedic use of a spinal injury clearance algorithm<br />
reduces spinal immobilization in the out-of-hospital<br />
setting. Prehosp Emerg Care 3(1):1-6 [LoE 1a]<br />
46. Nechwatal E (1975) [Critical notes on the transport of<br />
patients with cervical spinal cord injuries]. Chirurg<br />
46(11):521-523.<br />
47. Nockels RP (2001) Nonoperative Management of<br />
Acute Spinal Cord Injury. Spine 26(24S):<strong>S3</strong>1-"37<br />
48. Pointillart V, Petitjean ME, Wiart L, Vital JM, Lassie<br />
P, Thicoipe M, Dabadie P (2000) Pharmacological<br />
therapy of spinal cord injury during the acute phase.<br />
Spinal Cord 38(2):71-76.<br />
49. Prendergast MR, Saxe JM, Ledgerwood AM, Lucas<br />
CE, Lucas WF (1994) Massive steroids do not reduce<br />
the zone of injury after penetrating spinal cord injury.<br />
J Trauma 37(4):576-579; discussion 579-580.<br />
50. Raphael J, Chotai R (1994) Effects of the cervical<br />
collar on cerebrospinal fluid pressure. Anaesthesia<br />
49:437-439<br />
51. Rosen PB, McSwain NE, Arata M, Stahl S, Mercer D<br />
(1992) Comparison of two new immobilization<br />
collars. Ann Emerg Med 21(10):1189-1195<br />
52. Rosenfeld JF, Vaccaro AR, Albert TJ, Klein GR,<br />
Cotler JM (1998) The benefits of early decompression<br />
in cervical spinal cord injury. Am J Orthop 27(1):23-<br />
28.<br />
53. Ross SE, O`Malley KF, DeLong WG, Born CT,<br />
Schwab CW (1992) Clinical predictors of unstable<br />
cervical spinal injury in multiply injured patients.<br />
Injury 23(5):317-319 [LoE 2b]<br />
54. Sackett DL, Richardson WS, Rosenberg W, Haynes<br />
RB (1997) Evidence-based medicine: How to practice<br />
and teach EBM (London/UK, Churchill Livingstone)<br />
55. Sneed RC, Stover SL (1988) Undiagnosed spinal cord<br />
injuries in brain-injured children. Am J Dis Child<br />
142(9):965-967.<br />
56. Stiell IG, Wells GA, Vandemheen KL, Clement CM,<br />
Lesiuk H, De Maio VJ, Laupacis A, Schull M,<br />
McKnight RD, Verbeek R, Brison R, Cass D, Dreyer<br />
J, Eisenhauer MA, Greenberg GH, MacPhail I,<br />
Morrison L, Reardon M, Worthington J (2001) The<br />
canadian c-spine rule for radiopraphy in alert and<br />
stable trauma patients. JAMA 286(15):1841-1848<br />
57. Sung RD, Wang JC (2001) Correlation between a<br />
positive Hoffmann's reflex and cervical pathology in<br />
asymptomatic individuals. Spine 26(1):67-70.<br />
58. Tator CH (1996) Experimental and clincal studies of<br />
the pathophysiology and managment of acute spinal<br />
cord injury. J Spinal Cord Med 19:206-214<br />
Prehospital – Spine 102
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
59. Tator CH (1998) Biology of neurological recovery<br />
and functional restoration after spinal cord injury.<br />
Neurosurgery 42:696-708<br />
60. Tator CH, Duncan EG, Edmonds VE, Lapczak LI,<br />
Andrews DF (1995) Neurological recovery, mortality<br />
and l<strong>eng</strong>th of stay after acute spinal cord injury<br />
associated with changes in management. Paraplegia<br />
33(5):254-262.<br />
61. Vogel P (1992) [Neurologic disorders after injuries of<br />
the spine]. Langenbecks Arch Chir Suppl Kongressbd<br />
:271-273.<br />
62. Weinstein DE, Ko HY, Graziani V, Ditunno JF, Jr.<br />
(1997) Prognostic significance of the delayed plantar<br />
reflex following spinal cord injury. J Spinal Cord Med<br />
20(2):207-211.<br />
63. Wells JD, Nicosia S (1995) Scoring acute spinal cord<br />
injury: a study of the utility and limitations of five<br />
different grading systems. J Spinal Cord Med<br />
18(1):33-41.<br />
64. Wing PC, Nance P, Connell DG, Gagnon F (1998)<br />
Risk of avascular necrosis following short term<br />
megadose methylprednisolone treatment. Spinal Cord<br />
36(9):633-636.<br />
65. Young W (1993) Secondary injury mechanisms in<br />
acute spinal cord injury. J Emerg Med 11 (Suppl<br />
1):13-22.<br />
66. Zeidman SM, Ling GS, Ducker TB, Ellenbogen RG<br />
(1996) Clinical applications of pharmacologic<br />
therapies for spinal cord injury. J Spinal Disord 9:367-<br />
380<br />
67. Zhu Q, Ouyang J, Lu W, Lu H, Li Z, Guo X, Zhong S<br />
(1999) Traumatic instabilities of the cervical spine<br />
caused by high-speed axial compression in a human<br />
model. An in vitro biomechanical study. Spine<br />
24(5):440-444.<br />
Prehospital – Spine 103
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.7 Extremities<br />
Priority<br />
Key recommendations:<br />
Heavily bleeding extremity injuries, which can impair the vital function, must<br />
be given first priority.<br />
The management of extremity injuries must avoid further damage and not<br />
delay the total rescue time if there are additional threatening injuries present.<br />
Explanation:<br />
GoR A<br />
GoR A<br />
Securing the vital functions and examining the head and trunk should precede the examination of<br />
the extremities. Specifics can occur in extremity injuries with severe blood loss [21, 27].<br />
Severe and immediate life-threatening bleeding must be treated immediately even ignoring the<br />
ABCDE protocol (see page 133).<br />
Confirmation of more major, external bleeding which is not directly life-threatening is important<br />
and is usually carried out under “C” (circulation) whereas more minor bleeding comes under the<br />
“secondary survey” [21].<br />
The first rule is to avoid further damage, restore and maintain vital functions and transport to a<br />
suitable hospital [11, 25].<br />
The management of extremity injuries (irrigation/wound management/splinting) should not delay<br />
the rescue time if there are additional threatening injuries present [23].<br />
Diagnostic study<br />
Medical history<br />
A very detailed medical history (firsthand/third party) of the circumstances of the accident can<br />
be gathered to obtain sufficient information on the impacting force and, if applicable, the degree<br />
of contamination of open wounds [2, 27].<br />
If possible, information (allergies, medication, previous diseases and fasting state) should be<br />
collected in addition to the accident history and the time of the accident. In addition, details of<br />
tetanus immunization status should be obtained [21, 34].<br />
Prehospital – Extremities 104
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Examination<br />
Key recommendation:<br />
All extremities of a casualty should undergo an exploratory assessment in the<br />
prehospital phase.<br />
Explanation:<br />
GoR B<br />
Alert patients should be asked first whether they have any pain and where it is. If there is pain,<br />
adequate analgesics can be administered early on [21]. A prehospital examination should be<br />
carried out [11]. The examination at the accident scene should assess to an appropriate extent the<br />
severity of the injury without delaying the total rescue time too much [2]. The examination<br />
should be an exploratory survey from head to toe and not last longer than 5 minutes [34].<br />
The examination should be carried in the following order: inspection<br />
(malposition/wounds/swelling/circulation), stability test (crepitation, abnormal mobility, stable<br />
and unstable fracture signs), assessment of circulation, motor functions and sensitivity. Soft<br />
tissue findings should also be assessed (closed versus open fracture, compartment syndrome)<br />
[11, 21, 27].<br />
Leather clothing such as motorbike apparel, for example, should be left on if possible as this<br />
serves as a splint with compression effect particularly for the pelvis and the lower extremity [14,<br />
21].<br />
Capillary reperfusion can be tested by comparing with the uninjured limb [21].<br />
Treatment<br />
General<br />
Key recommendation:<br />
Even if an extremity injury is only suspected, it should be immobilized against<br />
rough movement and before transporting the patient.<br />
Explanation:<br />
GoR B<br />
Immobilizing an injured extremity is an important procedure in prehospital management. An<br />
extremity injury should be immobilized against rough movement and before transporting the<br />
patient. Reasons for this are to alleviate pain, prevent further soft tissue damage/bleeding and<br />
reduce the risk of a fat embolism and neurologic damage [21, 34].<br />
Even a suspected injury should be immobilized [10, 34].<br />
Prehospital – Extremities 105
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The joints proximal and distal to the injury should be included in the immobilization [10, 11, 24,<br />
34]. The injured extremity should be supported flat [4]. Particularly in shortened femoral<br />
fractures, traction/immobilization under traction should be carried out to minimize bleeding [2,<br />
21]. Vacuum splints are suitable for immobilizing an abnormal position. Vacuum splints are<br />
rigid and can adapt to the shape of the extremity [21]. Air chamber splints are suitable for<br />
splinting upper extremity injuries with the exclusion of injuries in the proximity of the shoulder<br />
joint. In the lower extremity, they are suitable for immobilizing knee, lower leg, and foot<br />
injuries. On their attachment, the pressure in the air chamber splints and the peripheral blood<br />
supply must be regularly checked [4]. The advantage of the air chamber splint is its low weight;<br />
the disadvantage is the compression of soft tissue which can cause secondary damage. Vacuum<br />
splints are therefore preferred. Air chamber and vacuum splints are unsuitable for immobilizing<br />
femoral fractures and those in the proximity of the shoulder joint [5]. Cooling can reduce<br />
swellings and help to alleviate pain [10]. Femur injuries can be adequately immobilized without<br />
complications with a spine board or rigid splinting. It is not absolutely necessary for traction<br />
splints to be carried in the emergency medical service.<br />
In a retrospective study with 4,513 callouts made by emergency paramedics in an American<br />
emergency medical system (EMS), 16 patients (0.35%) with injuries to the mid-femur were<br />
singled out. While 11 of these patients had only minor injuries, 5 of these patients (0.11% of all<br />
patients) were treated under a femoral fracture diagnosis. Three of these 5 patients received a<br />
traction splint. In one of the cases, the traction splint had to be removed again due to severe pain<br />
and a rigid immobilization device was attached. One patient could not have a traction splint<br />
because of simultaneous hip trauma. Another patient who was free of pain was transported in a<br />
comfortable position. The authors conclude that femur injuries and/or a suspected fracture are<br />
rare and can be well managed with a backboard or rigid immobilization. For this reason, it is not<br />
absolutely necessary for traction splints to be carried in the emergency medical service [1].<br />
Traction splints should not be used particularly on multiply injured patients as there are many<br />
contraindications for their use in these patients (pelvic fracture/knee/lower leg/ankle joint injury)<br />
[33]. They are only rarely used due to the existing contraindications on the use of a traction<br />
splint, particularly in critically injured patients. Dislocated proximal femoral fractures are also<br />
contraindications for the use of a traction splint [7].<br />
Traction splints are useful and, depending on the model, easy to use for immobilizing femoral<br />
fractures, even dislocated proximal femoral fractures. Further studies are necessary [8]. Traction<br />
splints reduce muscle spasms and thus alleviate pain. Traction helps to restore the femur shape<br />
and by reducing volume leads to a decrease in bleeding [8, 30, 31]. Oxygen can be given via a<br />
non-rebreather mask (15 l/min) [2, 21]. Jewelry (rings/chains) must be removed from the injured<br />
extremity [2, 10].<br />
Photos of wounds/open fractures can be taken for documentation (polaroid/digital). Photographic<br />
documentation of wounds, open fractures or discovered malpositions appears expedient as it can,<br />
under circumstances, avoid immobilized extremities or wounds already dressed in the<br />
prehospital phase from being exposed again in the hospital until they are definitively treated.<br />
Photographic documentation can assist the subsequent treating physician in assessing the injury.<br />
Photographic documentation must not extend the management/rescue time [2, 21].<br />
Prehospital – Extremities 106
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The severity and extent of the injuries must be documented in the emergency physician logbook<br />
and the local finding must be described to the subsequent treating surgeon, if possible in person<br />
[3].<br />
Fractures<br />
Key recommendation:<br />
If possible, and particularly with concomitant ischemia in the extremity<br />
concerned/with a long rescue time, grossly dislocated fractures and<br />
dislocations should be approximately reduced in the prehospital phase.<br />
Explanation:<br />
GoR B<br />
The primary goal is to secure the local and peripheral blood supply. The primary goal is not an<br />
exact anatomic reduction. What is more important is correct axial positioning and the restoration<br />
of an adequate local and peripheral blood supply [3, 5]. If the neurovascular supply to the<br />
extremity distal to the injury is not compromised, reduction can be ignored in principle [2]. If<br />
possible, and particularly with concomitant ischemia in the extremity concerned/with a long<br />
rescue time, grossly dislocated fractures and dislocations should be reduced in the prehospital<br />
phase by axial traction and manual correction into the neutral position or into a position that is<br />
nearest to the neutral position. It is important to check the peripheral blood supply and motor<br />
functions and sensitivity (where possible) before and after reduction [3, 4, 5, 11, 21, 25]. Too<br />
much longitudinal traction must be avoided as this increases compartmental pressure and<br />
worsens the blood supply in the soft tissue [3, 5].<br />
A neurologic or vascular deficit distal to the fracture requires an immediate reduction attempt.<br />
The same applies if the soft tissue sheath/skin is compromised [21]. After successful<br />
immobilization, circulation, sensitivity, and peripheral motor functions should be checked again<br />
[2, 21]. If neurovascular circulation deteriorates after a reduction attempt, the extremity must be<br />
immediately placed back in the initial position and stabilized as well as possible [21].<br />
Reduction of ankle fractures/ankle dislocation fractures should only be carried out by those<br />
experienced in this procedure. Otherwise, the goal is immobilization in the position found [21].<br />
In the case of commonly dislocated ankle joint fractures with obvious malposition, reduction can<br />
be carried out at the accident scene. With adequate analgesia, an approximately correct axial<br />
position can be achieved by controlled, continuous longitudinal traction with both hands on the<br />
calcaneus and heel of the foot; this position can then be immobilized. After this, the blood supply<br />
and neurologic situation should be recorded again.<br />
Obvious long bone fractures in the shaft area should also be treated in this way. Fractures in<br />
proximity to joints are difficult to assess in their extent and, after being immobilized in the painfree<br />
position found, can be transferred as rapidly as possible for further hospital diagnosis [2,<br />
34].<br />
Prehospital – Extremities 107
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Stronger longitudinal traction should be avoided in distal femoral fractures as this can<br />
compromise the popliteal vessels. The knee joint can be supported in a slightly bent position (30-<br />
50 degrees) [4].<br />
Open fractures<br />
Key recommendation:<br />
Each open fracture should be <strong>cleaned</strong> of coarse contamination and covered<br />
with a sterile dressing.<br />
Explanation:<br />
GoR B<br />
Each open fracture should be identified and coarse contamination immediately removed [21].<br />
Open fractures should be irrigated with physiologic saline solution [2, 21, 23, 26]. All open<br />
wounds should be covered with a sterile dressing [3, 4, 11, 21, 26, 34]. Without further cleansing<br />
or disinfection measures, open wounds must be covered with a large sterile dressing. Coarse<br />
contamination is removed [3, 4, 5]. Thereafter, they should be immobilized as for closed injuries<br />
[26, 34]. It is best if the dressings are not removed until in the operating room [21, 26].<br />
Antibiosis should be carried out at the earliest possible time. The risk of infection increases<br />
dramatically after 5 hours [26]. If available, intravenous antibiosis can be administered in the<br />
prehospital phase, usually with a 2nd generation cephalosporin which is easily distributed in the<br />
bone [4]. Prehospital antibiosis should be carried out if the rescue time is extended [23].<br />
Prehospital – Extremities 108
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendations:<br />
Active bleeding should be treated according to the following stepwise<br />
approach:<br />
� manual pressure/pressure dressing<br />
� (elevation)<br />
� tourniquet<br />
Indications for immediate use of a tourniquet/arrest of blood supply can be:<br />
� life-threatening bleeding/multiple sources of bleeding in an extremity<br />
� inability to reach the actual injury<br />
� several injured persons with bleeding<br />
Explanation:<br />
GoR B<br />
GoR 0<br />
The measures for arresting bleeding should follow a stepwise approach. A primary attempt<br />
should be made to arrest active bleeding by manual pressure and elevation of the extremity. Then<br />
a pressure dressing should be applied. If this is not adequate, a second pressure dressing should<br />
be applied over the first one. A sterile pad can be used to help to focus pressure. If bleeding<br />
persists, pressure should be applied to an artery proximal to the injury. In addition, if possible, a<br />
tourniquet should be applied. As an exception, the vessel can be clamped (amputation, longer<br />
transportation time, neck vessel, anatomic position makes the use of a tourniquet impossible) [3,<br />
4, 11, 21, 32].<br />
In regions where tourniquets cannot be applied (proximal extremities), hemostatic dressings can<br />
be used [13]. Applying a tourniquet requires appropriate analgesia [21]. A blood pressure cuff<br />
with 250 mmHg can be applied to the upper arm and one with 400 mmHg to the femur [3, 5].<br />
The time at which the tourniquet was applied should be noted [21, 22, 28]. The tourniquet must<br />
interrupt the arterial blood flow completely. An incorrectly applied tourniquet can intensify<br />
bleeding (only compromises low pressure system) [22]. Effectiveness is monitored by an arrest<br />
in bleeding rather than the disappearance of the distal pulse. In the case of a fracture, bleeding<br />
can also come from the bone marrow [22].<br />
Prehospital – Extremities 109
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Indications for immediate use of a tourniquet can be [22]:<br />
� Extreme bleeding/multiple sources of bleeding in an extremity necessitating parallel<br />
securing of vital functions<br />
� Inability to reach the actual injury (e.g., trapped person)<br />
� Mass casualty incident<br />
The following points should be borne in mind when applying a tourniquet:<br />
� Apply as far distally as possible, approx. 5 cm proximal to the injury<br />
� Apply directly on the skin to prevent it slipping [22, 28].<br />
If ineffective, re-apply with more pressure and only after that consider applying a second<br />
tourniquet directly proximal to the first [22]. Cooling an extremity that has a tourniquet applied<br />
can increase ischemic tolerance during long rescue times [15].<br />
There is only insufficient data on the safe application time for a tourniquet. The general<br />
recommendation is 2 hours but this has emerged from data obtained from normovolemic patients<br />
with a pneumatic tourniquet [22]. If the transportation time until surgery is less than 1 hour, the<br />
tourniquet can remain in situ. For longer rescue times (> 1 hour), attempts should be made to<br />
release the tourniquet in a stabilized patient. If bleeding should start again, the newly applied<br />
tourniquet should then remain in situ until it is managed in the operating room [22]. After 30<br />
minutes, the tourniquet should be checked to see if it is still necessary. This is not indicated if the<br />
patient is in shock or the attendant circumstances (personnel) are adverse [12].<br />
In a retrospective case series on war injured from the database of the British military, tourniquets<br />
were applied to 70 patients out of 1,375 patients who had been treated during the period in<br />
English field hospitals (5.1%). A total of 107 tourniquets were applied (17 of the treated [24%]<br />
had 2 or more tourniquets applied). Of this number, 5 had a double tourniquet applied for the<br />
same injury and 12 of the injured had bilateral tourniquets (maximum number per injured 4 - 2<br />
each on both lower extremities). A hundred and six tourniquets were applied prior to arrival at<br />
the field hospital. Sixty-one of these 70 patients (87.1%) survived. Mean value of the survivors:<br />
ISS = 16, mean value of fatalities (only 6 could be autopsied): ISS = 50.<br />
Whereas prior to the introduction of tourniquets as standard (February 2003 to April 2006) only<br />
9% (6 injured persons) were treated with a tourniquet, following introduction (April 2006<br />
through February 2007) it was 64 (91%). Without details of the total number of injured persons<br />
during this period, the authors indicate a 20-fold increase in the use of tourniquets. Three<br />
complications directly caused by the tourniquets were observed. There were 2 cases of<br />
compartment syndromes (one each in the femur and lower leg, one of which was due to incorrect<br />
application of the tourniquet) and one case of damage to the ulnar nerve (with no further details<br />
on the course). The use of tourniquets was assessed as life-saving in 4 cases of patients with<br />
isolated extremity injuries, hypovolemic shock and massive transfusion (and factor VIIa<br />
administration) [9].<br />
Prehospital – Extremities 110
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
In a retrospective study of 165 patients (inclusion criteria: traumatic amputation or severe vessel<br />
injury in extremities), Beekley et al. showed that the prehospital use of tourniquets led to<br />
improved control of bleeding; this relates particularly to multiply injured patients (ISS > 15).<br />
Forty percent of soldiers (n = 67) had a tourniquet. Reduced mortality could not be observed.<br />
The average tourniquet time was 70 minutes (min.: 5 minutes; max.: 210 minutes); damage due<br />
to use was not observed [6].<br />
In a prospective cohort study of 232 patients who had 428 tourniquets applied, Kragh et al.<br />
showed that there was no link between tourniquet time (average 1.3 hours) and morbidity<br />
(thromboses, number of fasciotomies, pareses, amputations). With tourniquet times over 2 hours,<br />
there is a trend towards increased morbidity with respect to amputations and fasciotomies.<br />
The tourniquet should be applied as early as possible. If a tourniquet does not lead to the<br />
disappearance of the distal pulse, a second should be applied directly proximal to the first one to<br />
increase effectiveness. There should be no materials underneath the tourniquet as they can lead<br />
to the tourniquet loosening. Tourniquets should be applied directly proximal to the wound. The<br />
effectiveness of tourniquets should be re-evaluated during the course [17]. The use of tourniquets<br />
is linked to a higher survival probability. The use of tourniquets before the occurrence of shock<br />
is linked to a higher survival probability, likewise when it is applied in the prehospital phase. No<br />
amputation has been require as a result of the use of a tourniquet.<br />
In a study of the US army in Baghdad with 2,838 injured persons with severe extremity injury,<br />
232 (8.2%) of those treated had 428 tourniquets applied (to 309 injured extremities). Of these,<br />
13% died. In a matched pair analysis (Abbreviated Injury Scale [AIS], Injury Severity Score<br />
[ISS], all male, age) of 13 injured persons with tourniquet applied (survival rate 77% [10 out of<br />
13]) and 5 (more were not identified in the time span) without tourniquet (but where there was an<br />
indication for tourniquet use and who all died in the prehospital phase [usually only 10-15<br />
minutes!]), it was shown that early use of tourniquets significantly increased the survival<br />
probability in severe extremity injuries (p < 0007). Ten of the injured only received the<br />
tourniquet in a manifest state of shock, and 9 (90%) died. Two hundred and twenty-two received<br />
the tourniquet before the onset of shock and only 22 died (10%, p < 0001). Twenty-two of the<br />
194 patients who already received the tourniquet in the prehospital phase (11%) and 9 of the 38<br />
(24%) who only received the tourniquet in the hospital’s emergency department died (p = 0.05).<br />
Ten cases of transient nerve paralysis occurred without any correlation to the l<strong>eng</strong>th of time the<br />
tourniquet was applied [18].<br />
The use of tourniquets is an effective, simple (for medical and non-medical personnel) method to<br />
prevent exsanguination in the military prehospital setting [20]. The use of tourniquets is a safe,<br />
rapid and effective method to control bleeding from an open extremity injury and should be used<br />
routinely and not only as a last resort (civil study) [16]. Tourniquets can contribute towards a<br />
reduction in mortality of those injured in battle and show only low complication rates (nerve<br />
paralysis, compartment syndrome). The loss of an extremity due to the use of a tourniquet is a<br />
rarity [13].<br />
Amputations<br />
Key recommendation:<br />
Prehospital – Extremities 111
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The amputated part should be <strong>cleaned</strong> of coarse contamination and wrapped<br />
in sterile, damp compresses. It should be indirectly chilled while being<br />
transported.<br />
Explanation:<br />
GoR B<br />
In addition to arresting bleeding, the amputation stump should be splinted and a sterile dressing<br />
applied. Only coarse contamination should be removed [3, 4]. The amputated part must be<br />
preserved. Bony parts or amputated digits should be taken from the accident scene or, if<br />
necessary, brought on afterwards.<br />
Wrap the amputated part in sterile, damp compresses and transport chilled, if possible packed<br />
using the “double bag method”. Here, the amputated part is packed in an inner plastic bag with<br />
sterile, damp compresses. This bag is placed in a bag with iced water (1/3 ice cubes, 2/3 water)<br />
and sealed. This avoids secondary cold damage (no direct contact between ice or cool pack and<br />
the tissue) [2–4, 19].<br />
Amputations influence the choice of designated hospital and advance warning should be given<br />
[2, 3].<br />
Prehospital – Extremities 112
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Abarbanell Nr (2001) Prehospital midthigh trauma<br />
and traction splint use: recommendations for treatment<br />
protocols. Am J Emerg Med 19:137-140<br />
2. Anonymous (2006) Limb trauma. In: School WM (ed)<br />
Clinical Practice Guidelines. For use in U.K.<br />
Ambulance Services. Guidelines of the Joint Royal<br />
Colleges Ambulance Liaison Committee and The<br />
Ambulance Service Association. Warwick Medical<br />
School, London, p<br />
http://www2.warwick.ac.uk/fac/med/research/hsri/em<br />
ergencycare/guidelines/limb_trauma_2006.pdf<br />
[Evidenzbasierte Leitlinie]<br />
3. Beck A (2002) Notärztliche Versorgung des<br />
Traumapatienten. Notfall- und Rettungsmedizin 1:57-<br />
61<br />
4. Beck A (2002) Wunde- Fraktur- Luxation. Notfall-<br />
und Rettungsmedizin 8:613-624<br />
5. Beck A, Gebhard F, Kinzl L et al. (2001) [Principles<br />
and techniques of primary trauma surgery<br />
management at the site]]. Unfallchirurg 104:1082-<br />
1096; quiz 1097, 1099<br />
6. Beekley Ac, Sebesta Ja, Blackbourne Lh et al. (2008)<br />
Prehospital tourniquet use in Operation Iraqi<br />
Freedom: effect on hemorrhage control and outcomes.<br />
J Trauma 64:S28-37; discussion <strong>S3</strong>7<br />
7. Bledsoe B, Barnes D (2004) Traction splint. An EMS<br />
relic? Jems 29:64-69<br />
8. Borschneck Ag (2004) Traction splint: proper splint<br />
design & application are the keys. Jems 29:70, 72-75<br />
9. Brodie S, Hodgetts Tj, Ollerton J et al. (2007)<br />
Tourniquet use in combat trauma: UK military<br />
experience. J R Army Med Corps 153:310-313<br />
10. Cuske J (2008) The lost art of splinting. How to<br />
properly immobilize extremities & manage pain.<br />
JEMS 33:50-64; quiz 66<br />
11. Dgu (2007) Leitlinie <strong>Polytrauma</strong>. In: Unfallchirurgie<br />
DGf (ed), p http://www.dguonline.de/de/leitlinien/polytrauma.jsp<br />
12. Doyle Gs, Taillac Pp (2008) Tourniquets: a review of<br />
current use with proposals for expanded prehospital<br />
use. Prehosp Emerg Care 12:241-256<br />
13. Ficke Jr, Pollak An (2007) Extremity War Injuries:<br />
Development of Clinical Treatment Principles. J Am<br />
Acad Orthop Surg 15:590-595<br />
14. Hinds Jd, Allen G, Morris Cg (2007) Trauma and<br />
motorcyclists: born to be wild, bound to be injured?<br />
Injury 38:1131-1138<br />
15. Irving Ga, Noakes Td (1985) The protective role of<br />
local hypothermia in tourniquet-induced ischaemia of<br />
muscle. J Bone Joint Surg Br 67:297-301<br />
16. Kalish J, Burke P, Feldman J et al. (2008) The return<br />
of tourniquets. Original research evaluates the<br />
effectiveness of prehospital tourniquets for civilian<br />
penetrating extremity injuries. JEMS 33:44-46, 49-50,<br />
52, 54<br />
17. Kragh Jf, Jr., Walters Tj, Baer Dg et al. (2008)<br />
Practical use of emergency tourniquets to stop<br />
bleeding in major limb trauma. J Trauma 64:<strong>S3</strong>8-49;<br />
discussion S49-50<br />
18. Kragh Jf, Jr., Walters Tj, Baer Dg et al. (2009)<br />
Survival with emergency tourniquet use to stop<br />
bleeding in major limb trauma. Ann Surg 249:1-7<br />
19. Lackner Ck, Lewan U, Deiler S et al. (1999)<br />
Präklinische Akutversorgung von<br />
Amputationsverletzungen. Notfall- und<br />
Rettungsmedizin 2:188-192<br />
20. Lakstein D, Blumenfeld A, Sokolov T et al. (2003)<br />
Tourniquets for hemorrhage control on the battlefield:<br />
a 4-year accumulated experience. J Trauma 54:S221-<br />
225<br />
21. Lee C, Porter Km (2005) Prehospital management of<br />
lower limb fractures. Emerg Med J 22:660-663 [LoE<br />
4]<br />
22. Lee C, Porter Km, Hodgetts Tj (2007) Tourniquet use<br />
in the civilian prehospital setting. Emerg Med J<br />
24:584-587<br />
23. Melamed E, Blumenfeld A, Kalmovich B et al. (2007)<br />
Prehospital care of orthopedic injuries. Prehosp<br />
Disaster Med 22:22-25<br />
24. Perkins Tj (2007) Fracture management. Effective<br />
prehospital splinting techniques. Emerg Med Serv<br />
36:35-37, 39<br />
25. Probst C, Hildebrand F, Frink M et al. (2007)<br />
[Prehospital treatment of severely injured patients in<br />
the field: an update]. Chirurg 78:875-884 [LoE 5]<br />
26. Quinn Rh, Macias Dj (2006) The management of<br />
open fractures. Wilderness Environ Med 17:41-48<br />
27. Regel G, Bayeff-Filloff M (2004) [Diagnosis and<br />
immediate therapeutic management of limb injuries.<br />
A systematic review of the literature]. Unfallchirurg<br />
107:919-926 [LoE 3a]<br />
28. Richey Sl (2007) Tourniquets for the control of<br />
traumatic hemorrhage: a review of the literature.<br />
World J Emerg Surg 2:28<br />
29. Sackett Dl, Richardson Ws, Rosenberg W et al.<br />
(1997) Evidence-based medicine: How to practice and<br />
teach EBM. Churchill Livingstone, London<br />
30. Scheinberg S (2004) Traction splint: questioning<br />
commended. Jems 29:78<br />
31. Slishman S (2004) Traction splint: sins of commission<br />
vs. sins of omission. Jems 29:77-78<br />
32. Strohm Pc, Bannasch H, Goos M et al. (2006)<br />
[Prehospital care of surgical emergencies]. MMW<br />
Fortschr Med 148:34, 36-38<br />
33. Wood Sp, Vrahas M, Wedel Sk (2003) Femur fracture<br />
immobilization with traction splints in multisystem<br />
trauma patients. Prehosp Emerg Care 7:241-243<br />
34. Worsing Ra, Jr. (1984) Principles of prehospital care<br />
of musculoskeletal injuries. Emerg Med Clin North<br />
Am 2:205-217<br />
Prehospital – Extremities 113
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.8 Genitourinary tract<br />
Key recommendation:<br />
In the case of a suspected urethral injury, prehospital bladder catheterization<br />
should not be carried out.<br />
Explanation:<br />
GoR B<br />
Genitourinary tract injuries can occur in approximately 5-10% of cases of multiply injured<br />
persons and are thus relatively frequent. In numbers, kidney injuries are at the forefront,<br />
followed by bladder and urethra. In contrast, about half of all urologic trauma are associated with<br />
further injuries consistent with multiple injuries [1, 7]. Relatively severe and combined<br />
genitourinary injuries typically occur only with multiple injuries [4, 7]. Due to their relative<br />
frequency and clinical importance, recommendations shall be given below for injuries to the<br />
kidney, ureters, bladder, and urethra. In contrast, injuries to the external genital organs are not<br />
discussed as they are relatively rare and are usually treated in a similar way in polytrauma as in<br />
monotrauma.<br />
In contrast to other injuries, injuries to the ureter, bladder, and urethra do not represent a direct<br />
threat to life (evidence level [EL] 4 [2]). Although kidney ruptures are potentially lifethreatening,<br />
they cannot be treated in the prehospital phase. Accordingly, there are scarcely any<br />
specific prehospital procedures for diagnosis and treatment of urological injuries. A diagnosis<br />
time advantage is assumed only for the transurethral catheterization of the bladder because the<br />
presence and severity grade of hematuria can be important both in the choice of designated<br />
hospital and for its management upon arrival in hospital. As time losses represent a relevant risk<br />
quoad vitam to multiply injured patients particularly in prehospital care, prehospital<br />
catheterization may be advantageous if longer rescue/transport times are predicted providing it in<br />
turn does not lead to delays. Internationally, the transurethral bladder catheter is a quite common<br />
procedure in the prehospital treatment of multiply injured patients.<br />
There is a slight risk that an additional injury is caused through bladder catheterization (EL 4 [3])<br />
by turning an incomplete urethral rupture into a complete rupture. In addition, the transurethral<br />
catheter can cause a via falsa in a complete urethral rupture (EL 5 [5, 6]). Based on these<br />
considerations, it seems advisable to dispense with transurethral catheterization in patients with<br />
clinical signs of a urethral injury until the diagnostic study has been completed. Hematuria<br />
and/or blood leakage from the meatus urethra are the main clinical criteria for a urethral injury.<br />
In addition, dysuria, suspected pelvic fracture, local hematoma development, and the general<br />
mechanism of injury can provide diagnostic clues.<br />
Prehospital – Genitourinary tract 114
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1 Cass AS, Cass BP. Immediate surgical management<br />
of severe renal injuries in multiple-injured patients.<br />
Urology 1983: 21(2):140-145.<br />
2 Corriere JN, Jr., Sandler CM. Management of the<br />
ruptured bladder: seven years of experience with 111<br />
cases. J Trauma 1986: 26(9):830-833 [LoE 4]<br />
3 Glass RE, Flynn JT, King JB, Blandy JP. Urethral<br />
injury and fractured pelvis. Br J Urol 1978:<br />
50(7):578-582 [LoE 4]<br />
4 Monstrey SJ, vander WC, Debruyne FM, Goris RJ.<br />
Urological trauma and severe associated injuries. Br J<br />
Urol 1987: 60(5):393-398.<br />
5 Morehouse DD, Mackinnon KJ. Posterior urethral<br />
injury: etiology, diagnosis, initial management.<br />
UrolClin North Am 1977: 4(1):69-73 [LoE 5]<br />
6 Nagel R, Leistenschneider W. [Urologic injuries in<br />
patients with multiple injuries]. Chirurg 1978:<br />
49(12):731-736 [LoE 5]<br />
7 Zink RA, Muller-Mattheis V, Oberneder R. [Results<br />
of the West German multicenter study "Urological<br />
traumatology"]. Urologe A 1990: 29(5):243-250.<br />
Prehospital – Genitourinary tract 115
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.9 Transport and designated hospital<br />
Key recommendation:<br />
Primary air rescue can be used for the prehospital management of severely<br />
injured persons as it can result in a survival advantage particularly for<br />
medium to high injury severity.<br />
Explanation:<br />
GoR 0<br />
For years, air rescue has been a permanent component in the care provided by the emergency<br />
services not only in Germany but also internationally. In most European countries, a<br />
comprehensive network of air rescue bases has been built up over recent decades covering the<br />
primary and secondary management sectors. Numerous studies to date have tried to prove the<br />
effectiveness of air rescue. Thus, a possibly shorter prehospital period (time of accident until<br />
hospital admission) and more aggressive prehospital treatment have been referred to as potential<br />
grounds for an improved outcome in multiply injured patients. For a long time, however, it<br />
remained controversial whether the use of air rescue actually led to a reduction in mortality. A<br />
lack of medical effectiveness together with high contingency costs has thus put a question mark<br />
over air rescue for primary use.<br />
The necessity of the partly enormous logistic contingency costs in trauma centers has also come<br />
under question. In addition to expensive technology, staff resources in particular have been held<br />
in readiness, necessary for the optimum logistic management of multiply injured patients. Up till<br />
now, there has also been a lack of justifiable study conclusions on the rationale of high<br />
contingency costs.<br />
The results of the prehospital management of multiply injured patients by air rescue were<br />
compared in 19 studies (evidence Level 2b [2–6, 8, 11, 14, 16, 17, 18, 20, 21, 28, 29, 32] with<br />
those of land-based rescue. The case fatality rate was the primary endpoint here in all cases. Nine<br />
studies were designed as prospective, 8 studies as retrospective, and 6 studies were multicenter.<br />
In 16 studies, the primary designated hospital was exclusively a Level 1 trauma center [1], and in<br />
one study [20] Level 2/3 hospitals were also involved.<br />
Case fatality rate<br />
In 11 studies there was evidence of a statistically significant reduction in case fatality rate<br />
(between -8.2 and -52%) through the use of air rescue. Six studies show no advantage in<br />
outcome for patients transported by air rescue but reveal the following abnormalities:<br />
Phillips et al. 1999 [21]: With identical case fatality rates in both patient groups, the injury<br />
severity of the rescue helicopter (RTH) group was increased highly significantly (p < 0001); an<br />
adjusted case fatality rate comparison was not carried out. Schiller et al. 1988 [28]: The patients<br />
in the rescue helicopter group had both a significantly increased case fatality rate and a<br />
significantly higher injury severity; an adjusted case fatality rate comparison was not carried out.<br />
Nicholl et al. 1995 [20]: The patients in both treatment groups were also treated in Level 2 and 3<br />
Prehospital – Transport and designated hospital 116
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
hospitals as well as trauma centers. Cunningham et al. 1997 [11]: Patients in the rescue<br />
helicopter group with mean injury severity (ISS = 21–30) had a significantly reduced case<br />
fatality rate; but this result was not confirmed in the logistic regression. Bartolomeo et al. 2001<br />
[12]: Only patients with severe head injuries (AIS ≥ 4) were studied. The land-based emergency<br />
physician team also carried out invasive prehospital treatment interventions comparatively<br />
frequently so that the “gap” between their treatment level and that of the rescue helicopter group<br />
was only very slight. In Biewener et al. (2004) [5]: In their own paper it is also noticeable that a<br />
comparatively high level of invasive prehospital treatment is carried out by the land-based<br />
emergency physician team.<br />
Comparability and transferability of study results<br />
As a result of very different country-specific emergency service structures, the comparability of<br />
the studies must be questioned. For instance, a rescue system based on paramedics is found<br />
particularly in the North American region, whose structure cannot be compared with the German<br />
rescue service. The studies also differ noticeably in the injury pattern. For instance, blunt injuries<br />
in particular are predominant in European countries whereas penetrating trauma are predominant<br />
in North America. The studies also differ enormously in the transport distances to be covered<br />
and the aggressiveness of the prehospital management. The majority of the studies (11/17) show<br />
a statistically significant reduction in case fatality rate of multiply injured patients - particularly<br />
with average injury severity - through the use of air rescue. The 6 studies without evidence of a<br />
direct treatment advantage nevertheless reveal a trend towards better results with helicopter<br />
patients through increased injury severity with identical case fatality rate.<br />
Furthermore, all studies show a marked extension to the prehospital period. This is firstly<br />
because of a partly markedly longer transport distance, and secondly because of a markedly more<br />
aggressive prehospital management strategy. However, further evidence on the effectiveness of<br />
aggressive prehospital treatment is incomplete.<br />
In summary, these papers show a trend towards a fall in the case fatality rate of multiply injured<br />
patients through the use of air rescue compared with the land-based emergency service. This is<br />
particularly relevant to patients with average injury severity whose survival is particularly<br />
strongly dependent on treatment effects. The reasons are considered to be a better clinical<br />
diagnostic study and treatment due to the rescue helicopter team’s training and experience<br />
advantages. This conclusion is limited in its general validity and transferability by the listed<br />
systematic error sources of the cited papers and by the heterogeneity of the regional emergency<br />
service and hospital structures and of the types of injury.<br />
Comparison of trauma center versus hospital level II and III<br />
The importance of the duration of prehospital management of multiply injured patients has been<br />
proven in numerous studies and the term “golden hour” has been coined. The goal must be to<br />
transport the patient to a hospital which has at its disposal a 24-hour acute diagnostic and acute<br />
treatment unit in terms of prompt availability of all medical and surgical disciplines and the<br />
provision of corresponding capacities for acute treatment. Furthermore, it was shown that<br />
hospitals with a high footfall of critically injured patients had a clearly better outcome than<br />
facilities with markedly less annual revenue.<br />
Prehospital – Transport and designated hospital 117
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
Severely injured patients should be primarily transferred to a trauma center. GoR B<br />
Explanation:<br />
Hospital level:<br />
In the analysis of the studies, the term hospital levels 1-3 and partly also 1-4 are used. In this<br />
context, a Level 1 hospital equates to a maximum care hospital, which normally represents a<br />
trauma center, a term which does not have an internationally consistent definition.<br />
A care Level 2 hospital equates to a specialist hospital, and a care level 3 hospital equates to a<br />
basic, general hospital.<br />
Through the development of <strong>DGU</strong> trauma networks, 3 new categories of trauma care have been<br />
defined [24, 31]: “transboundary trauma center”, “regional trauma center”, and “basic care<br />
facilities”.<br />
Each care level is clearly defined using a certification procedure and is obliged to maintain the<br />
required performance. In addition to the previous structures, these facilities are linked to each<br />
other via “network development”. This enables shared resources and integrated patient care.<br />
Based on those trauma networks which are being developed and the corresponding lack of<br />
studies, the existing hospital grades (Level 1-3) have to be used to define the designated hospital<br />
recommendations. However, it might be possible to assume from an interlinking of various care<br />
centers that even the care quality of regional trauma centers legitimizes polytrauma care.<br />
The German Trauma Society (<strong>DGU</strong>) has developed the White Paper in association with the<br />
development of the trauma network [31]. It summarizes inter alia data of relevant international<br />
and national care studies, prospective data in the trauma registry of the German Trauma Society,<br />
and data and literature analyses of the interdisciplinary working group “<strong>S3</strong> Guideline of the<br />
<strong>DGU</strong> on the treatment of seriously and multiply injured patients” in order to give<br />
recommendations on the structure, organization, and equipment for the care of the severely<br />
injured.<br />
The authors of the White Paper recommend that a severely injured patient is transferred to the<br />
nearest regional or transboundary trauma center if there is an indication for emergency room<br />
management based on mechanism of injury, injury pattern, and vital parameters and if the<br />
trauma center can be reached within 30 minutes’ drive time. If it cannot be reached in that time,<br />
the patient must be transported to an adequately equipped smaller hospital (currently called a<br />
basic care facility). If a criterion exists for onward transfer, secondary transfer to a regional or<br />
transboundary trauma center is carried out from there after the vital parameters have been<br />
stabilized.<br />
Prehospital – Transport and designated hospital 118
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Comparison of Level 1-trauma center versus Level 2/3 hospitals<br />
The research yielded 7 studies from the USA (n = 3), Canada (n = 2), Australia (n = 1), and<br />
Germany (n = 1), which directly compare the results of trauma centers (maximum care hospital)<br />
with Level 2/3 hospitals (specialist/basic and general care) [5, 9, 10, 15, 23, 26, 27].<br />
All papers come to the conclusion that the case fatality rate is lowered if the primary treatment of<br />
patients with serious blunt and penetrating injuries is carried out in the trauma center. This result<br />
is statistically significant in 5 studies. The significance level falls just short (p = 0.055) in one<br />
study [27]. Differences in prehospital management (prehospital interval, amount of treatment)<br />
which could have contributed to the difference in the case fatality rate were documented only in<br />
their own paper. The interpretation of the study results is simplified in that all papers come to a<br />
comparable, statistically confirmed result: the case fatality rate of multiply injured patients is<br />
lowered through direct admission to a trauma center or a hospital with a comparable quality of<br />
care.<br />
However, due to the considerable, not fully controlled sources of bias and the heterogeneity of<br />
the care systems studied, this conclusion cannot equate to definitive scientific evidence. Some<br />
authors pointed out that stabilization in a regional hospital followed by transfer to a trauma<br />
center, did not negatively influence the case fatality rate compared to patients directly admitted<br />
to the trauma center [7, 13, 19, 22, 30, 31, 33]. Patients who died before a possible transfer are<br />
not included in these papers. The “transfer” patient cohort is thus positively selected. This should<br />
be taken into consideration in the <strong>final</strong> analysis. It is thus not possible to conclude whether this<br />
care pathway actually does represent an equivalent alternative to direct admission to a trauma<br />
center or a hospital of comparable quality of care.<br />
Furthermore, a fresh analysis of the treatment results at all care levels must be conducted after<br />
the trauma networks are implemented to provide scientific proof of potential positive effects on<br />
the outcome from networking.<br />
Conclusion<br />
The analyzed papers on comparing air rescue with the land-based emergency service reveal a<br />
trend towards a fall in the case fatality rate through the use of air rescue. If available, primary air<br />
rescue can be used for the prehospital care of severely injured persons as it can result in a<br />
survival advantage particularly for medium to high injury severity. Severely injured patients<br />
should undergo primary transfer to a trauma center as this procedure leads to a lowering of the<br />
case fatality rate. If a regional or transboundary trauma center cannot be reached within a<br />
reasonable time (White Paper recommendation: 30 minutes), then the patient should be taken to<br />
a closer hospital which is able to carry out primary stabilization and life-saving first aid<br />
measures. During the further course, if circulation is stable and specific criteria are present,<br />
secondary transfer to a regional or transboundary trauma center can be carried out if necessary.<br />
Prehospital – Transport and designated hospital 119
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Anonymous (1979) Hospital resources for optimal<br />
care of the injured patient. Prepared by a Task force of<br />
the Committee on Trauma of the American College of<br />
Surgeons. Bull Am Coll Surg 64:43-48<br />
2. Bartolacci Ra, Munford Bj, Lee A et al. (1998) Air<br />
medical scene response to blunt trauma: effect on<br />
early survival. Med J Aust 169:612-616 [LoE 2b]<br />
3. Baxt Wg, Moody P (1983) The impact of a rotorcraft<br />
aeromedical emergency care service on trauma<br />
mortality. JAMA 249:3047-3051 [LoE 2b]<br />
4. Baxt Wg, Moody P (1987) The impact of advanced<br />
prehospital emergency care on the mortality of<br />
severely brain-injured patients. J Trauma 27:365-369<br />
[LoE 2b]<br />
5. Biewener A, Aschenbrenner U, Rammelt S et al.<br />
(2004) Impact of helicopter transport and hospital<br />
level on mortality of polytrauma patients. J Trauma<br />
56:94-98 [LoE 2b]<br />
6. Brathwaite Ce, Rosko M, Mcdowell R et al. (1998) A<br />
critical analysis of on-scene helicopter transport on<br />
survival in a statewide trauma system. J Trauma<br />
45:140-144; discussion 144-146 [LoE 2b]<br />
7. Bunn F, Kwan I, Roberts I et al. (2001) Effectiveness<br />
of pre-hospital trauma care. Report to the World<br />
Health Organisation Pre-Hospital Care Steering<br />
Committee. . In:<br />
8. Buntman Aj, Yeomans Ka (2002) The effect of air<br />
medical transport on survival after trauma in<br />
Johannesburg, South Africa. S Afr Med J 92:807-811<br />
[LoE 2b]<br />
9. Clemmer Tp, Orme Jf, Jr., Thomas Fo et al. (1985)<br />
Outcome of critically injured patients treated at Level<br />
I trauma centers versus full-service community<br />
hospitals. Crit Care Med 13:861-863<br />
10. Cooper Dj, Mcdermott Ft, Cordner Sm et al. (1998)<br />
Quality assessment of the management of road traffic<br />
fatalities at a level I trauma center compared with<br />
other hospitals in Victoria, Australia. Consultative<br />
Committee on Road Traffic Fatalities in Victoria. J<br />
Trauma 45:772-779<br />
11. Cunningham P, Rutledge R, Baker Cc et al. (1997) A<br />
comparison of the association of helicopter and<br />
ground ambulance transport with the outcome of<br />
injury in trauma patients transported from the scene. J<br />
Trauma 43:940-946 [LoE 2b]<br />
12. Di Bartolomeo S, Sanson G, Nardi G et al. (2001)<br />
Effects of 2 patterns of prehospital care on the<br />
outcome of patients with severe head injury. Arch<br />
Surg 136:1293-1300<br />
13. Kearney Pa, Terry L, Burney Re (1991) Outcome of<br />
patients with blunt trauma transferred after diagnostic<br />
or treatment procedures or four-hour delay. Ann<br />
Emerg Med 20:882-886<br />
14. Kerr Wa, Kerns Tj, Bissell Ra (1999) Differences in<br />
mortality rates among trauma patients transported by<br />
helicopter and ambulance in Maryland. Prehosp<br />
Disaster Med 14:159-164 [LoE 2b]<br />
15. Mackenzie Ej, Rivara Fp, Jurkovich Gj et al. (2006) A<br />
national evaluation of the effect of trauma-center care<br />
on mortality. N Engl J Med 354:366-378<br />
16. Moront Ml, Gotschall Cs, Eichelberger Mr (1996)<br />
Helicopter transport of injured children: system<br />
effectiveness and triage criteria. J Pediatr Surg<br />
31:1183-1186; discussion 1187-1188 [LoE 2b]<br />
17. Moylan Ja, Fitzpatrick Kt, Beyer Aj, 3rd et al. (1988)<br />
Factors improving survival in multisystem trauma<br />
patients. Ann Surg 207:679-685 [LoE 2b]<br />
18. Nardi G, Massarutti D, Muzzi R et al. (1994) Impact<br />
of emergency medical helicopter service on mortality<br />
for trauma in north-east Italy. A regional prospective<br />
audit. Eur J Emerg Med 1:69-77 [LoE 2b]<br />
19. Nathens Ab, Maier Rv, Brundage Si et al. (2003) The<br />
effect of interfacility transfer on outcome in an urban<br />
trauma system. J Trauma 55:444-449<br />
20. Nicholl Jp, Brazier Je, Snooks Ha (1995) Effects of<br />
London helicopter emergency medical service on<br />
survival after trauma. BMJ 311:217-222 [LoE 2b]<br />
21. Phillips Rt, Conaway C, Mullarkey D et al. (1999)<br />
One year's trauma mortality experience at Brooke<br />
Army Medical Center: is aeromedical transportation<br />
of trauma patients necessary? Mil Med 164:361-365<br />
[LoE 2b]<br />
22. Rogers Fb, Osler Tm, Shackford Sr et al. (1999) Study<br />
of the outcome of patients transferred to a level I<br />
hospital after stabilization at an outlying hospital in a<br />
rural setting. J Trauma 46:328-333<br />
23. Rogers Fb, Osler Tm, Shackford Sr et al. (2001)<br />
Population-based study of hospital trauma care in a<br />
rural state without a formal trauma system. J Trauma<br />
50:409-413; discussion 414<br />
24. Ruchholtz S, Kuhne Ca, Siebert H (2007) [Trauma<br />
network of the German Association of Trauma<br />
Surgery (<strong>DGU</strong>). Establishment, organization, and<br />
quality assurance of a regional trauma network of the<br />
<strong>DGU</strong>]. Unfallchirurg 110:373-379<br />
25. Sackett Dl, Richardson Ws, Rosenberg W et al.<br />
(1997) Evidence-based medicine: How to practice and<br />
teach EBM. Churchill Livingstone, London<br />
26. Sampalis Js, Denis R, Lavoie A et al. (1999) Trauma<br />
care regionalization: a process-outcome evaluation. J<br />
Trauma 46:565-579; discussion 579-581<br />
27. Sampalis Js, Lavoie A, Williams Ji et al. (1993)<br />
Impact of on-site care, prehospital time, and level of<br />
in-hospital care on survival in severely injured<br />
patients. J Trauma 34:252-261<br />
28. Schiller Wr, Knox R, Zinnecker H et al. (1988) Effect<br />
of helicopter transport of trauma victims on survival<br />
in an urban trauma center. J Trauma 28:1127-1134<br />
[LoE 2b]<br />
29. Schwartz Rj, Jacobs Lm, Yaezel D (1989) Impact of<br />
pre-trauma center care on l<strong>eng</strong>th of stay and hospital<br />
charges. J Trauma 29:1611-1615 [LoE 2b]<br />
30. Sharar Sr, Luna Gk, Rice Cl et al. (1988) Air transport<br />
following surgical stabilization: an extension of<br />
regionalized trauma care. J Trauma 28:794-798<br />
Prehospital – Transport and designated hospital 120
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
31. Siebert Hr, Ruchholtz S (2007) Projekt<br />
Traumanetzwerk <strong>DGU</strong>. Trauma Berufskrankheit<br />
9:265-270<br />
32. Thomas Sh, Harrison Th, Buras Wr et al. (2002)<br />
Helicopter transport and blunt trauma mortality: a<br />
multicenter trial. J Trauma 52:136-145 [LoE 2b]<br />
33. Veenema Kr, Rodewald Le (1995) Stabilization of<br />
rural multiple-trauma patients at level III emergency<br />
departments before transfer to a level I regional<br />
trauma center. Ann Emerg Med 25:175-181<br />
Prehospital – Transport and designated hospital 121
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
1.10 Mass casualty incident (MCI)<br />
The mass casualty incident represents a big chall<strong>eng</strong>e for the medical team management.<br />
Screening and triage of emergency patients must utilize the available personnel and material<br />
resources as efficiently as possible in the prehospital individual management of the injured.<br />
Following the attacks inter alia in Madrid and London and the Football World Cup in Germany<br />
in 2006, for example, the extreme topicality of this problem should not be in dispute.<br />
The major catastrophic event must be differentiated from a disaster. A strategy for controlling a<br />
major catastrophic event with a mass casualty incident was drawn up here according to<br />
methodological criteria; its transferability and application in a disaster scenario is only possible<br />
to a limited extent at this juncture.<br />
Results<br />
The literature screening revealed that there is no literature of Evidence Level 1 according to the<br />
current state of knowledge. The major literature citations for Level 2 and 3 are: [4, 6, 10, 11, 12,<br />
15, 16, 20, 22, 23, 27, 37, 41, 43, 44, 50, 56, 57, 63, 64, 74]. Case histories are difficult to extract<br />
from literature citations for Evidence Level 3 as they are generally the only authentic and<br />
practically utilizable experience reports of major catastrophic events. For this reason, these<br />
publications are also classified in our guideline under Evidence Levels 4 and 5: [1, 3, 5, 8, 9, 13,<br />
14, 17, 18, 21, 23, 30–33, 36, 38–40, 42, 45, 47, 49, 51–53, 55, 58–62, 67, 69–71, 73, 75, 76].<br />
Computer simulations were also applied; their quality is also up for discussion [29, 65].<br />
Status of discussion<br />
Due to the present data status, the evidence-based development of a strategy for the mass<br />
casualty incident is currently not possible. As no evidence could be found for individual steps<br />
and individual research questions, the authors initially developed a proposal from the synopsis of<br />
literature and their own experiences to illustrate the process management in a mass casualty<br />
incident. While assessing available study results, the appointed experts group therefore carried<br />
out a formal consensus process to draw up the treatment strategy. Within the framework of the<br />
nominal group process, the individual opinions could be modified, thus enabling the<br />
requirements for a democratic consensus to be fulfilled with appropriate legitimization [35, 54].<br />
The relevant decision criteria and intervention options were defined accordingly and assessed in<br />
order of priority with regard to presenting them using an algorithm. To present the results, a<br />
modified flow diagram was selected which gives sufficient clarity despite the complexity of the<br />
task [34]. The <strong>final</strong> approval was obtained in a Delphi conference [24]: the anonymized opinions<br />
of the experts were gathered by interview and listed. Several survey rounds followed and after<br />
each round the responses received were summarized and submitted again for appraisal by those<br />
surveyed. This led to systematic modification and criticism of the summarized responses. A<br />
group response was achieved by summarizing the individual opinions in a <strong>final</strong> round, after<br />
which it was possible to produce a convergence of opinions.<br />
The algorithm developed for the prehospital processing of a major catastrophic event with a<br />
mass casualty incident defines as a treatment strategy both the entire process and the major<br />
Prehospital – Mass casualty incident (MCI) 122
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
decision points and management steps. It consists of 2 parts: action instructions for the<br />
ambulance team management (SanEL, consisting of the lead emergency physician, LEP, and the<br />
organizational leader of the emergency service (OrgL) and part 2, the triage of the injured. The<br />
essential prerequisite for processing it is to ensure the accident scene is safe so that the personnel<br />
involved are not exposed to any unnecessary hazard.<br />
Discussion<br />
At a mass casualty incident, it is generally not possible for time reasons for the lead emergency<br />
physician to carry out prehospital individual triage of all patients. Although there is a good half<br />
dozen published triage instructions in the literature, these are neither applicable to the individual<br />
medical care systems in equal measure nor do they reveal any type of relatively high evidence<br />
[19]. Thus, our own triage algorithm, which can be well and easily applied to the German<br />
emergency services conditions, had to be developed from the data in the literature and from the<br />
experiences of the members of the consensus conference. The START (Simple Triage and Rapid<br />
Treatment) algorithm commonly used in North America, which enables a targeted sorting of the<br />
injured by the emergency services personnel first on the scene, serves as an important basis for<br />
the algorithm developed for prehospital triage. The START strategy was initially developed for<br />
the Californian fire department [10] and is superior to other triage algorithms in the recognition<br />
of critical injuries [28]. Besides the priorities according to the ATLS ® specifications [2], the<br />
algorithm developed for prehospital triage also takes account of the specific requirements of the<br />
German emergency system [68], both with regard to the tasks and activity of the lead emergency<br />
physician or of the ambulance team management and to the appropriate screening categories.<br />
Triage is generally made more difficult in that the severely injured must be rapidly and definitely<br />
identified from among a large number of casualties with minor injuries. Usually, the problem is<br />
less one of undertriage, in other words, of not recognizing critically at-risk patients, and far more<br />
one of overtriage, of the incorrect assessment of the non-critically injured. The rate of overtriage<br />
correlates linearly with the mortality of the critically injured [25] as prehospital and hospital<br />
resources are used up in the initially non-urgent treatment of those with minor injuries when<br />
these resources are urgently required for the treatment of the critically injured.<br />
After triage has commenced, all the walking wounded are first of all sent to a collection point for<br />
those with minor injuries. Patients whose vital functions are acutely threatened are identified<br />
according to the ABCD priorities (Airway, Breathing, Circulation, Disability) and dispatched for<br />
treatment as rapidly as possible. If there is an acute surgical indication such as<br />
thoracotomy/laparotomy to arrest bleeding or decompression in the case of traumatic brain<br />
injury, the patient is transported without delay to the nearest suitable hospital after a second<br />
screening and approval given by the lead emergency physician (or the SanEL).<br />
The algorithm particularly takes account of the problem that among the large number of injured<br />
only a small proportion of the patients have acutely threatened vital functions and require<br />
immediate treatment. Besides the life-saving interventions that can be carried out at the scene, it<br />
also includes the rapid, resource-dependent transportation to acute surgical care.<br />
An additional fifth screening category for dead persons accommodates the requirement of the<br />
European Consensus Conference [68] to assign dead persons and still alive patients who<br />
Prehospital – Mass casualty incident (MCI) 123
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
nevertheless have no hope of survival due to their injuries to their own group instead of the<br />
hitherto usual 4 groups.<br />
The strategy introduced for the mass casualty incident is essentially based on the results of the<br />
consensus conference where there is insufficient data available. Studies of Evidence Level 2 use<br />
simulation models for the major catastrophic situation using analysis of carefully documented<br />
populations of trauma patients [28] or of events such as the Munich Oktoberfest with a pile-up of<br />
many casualties [63]. Although the partial issue of screening and triage can be researched in this<br />
way, the operational logistics cannot be recorded with such studies.<br />
The following problems relating to process quality are identified both in the literature [6, 32, 46]<br />
and by the members of the working group:<br />
� Lack of communication at the scene and with the competent superordinate locations<br />
(hospitals, emergency control center, etc.)<br />
� Persons in charge at the scene are not clearly identified<br />
� Lack of documentation of the incident<br />
� Lack of identification of the injured<br />
Summary:<br />
Finally, the following conclusion should be drawn: contingencies cannot be predicted or<br />
practiced in advance in the context of a major catastrophic event and definitely not in a disaster.<br />
In such situations, it has been proven of more advantage to build up available structures as<br />
required (regular emergency services, fire department, ambulance service, disaster protection,<br />
etc.) rather than create new structures for major catastrophic events. But one thing still stands:<br />
good preparation and good training [26] are the best basic prerequisites for dealing with such a<br />
situation despite all contingencies [33, 48]. This means the sensible overhaul and improvement<br />
in process quality by all local committees involved. Simulation games are a suitable means for<br />
evaluation. The algorithm specified by us for processing a major catastrophic event must be<br />
included in the local considerations which relate (according to Stratmann) to the medical care<br />
principles and to coordinating the cooperation of the emergency services with other<br />
organizations (e.g., fire department, police, ambulance service, disaster protection, German<br />
army) [72]. The algorithm should be adapted as required to local circumstances, and existing<br />
disaster protection plans or similar should also be adapted to it.<br />
Prehospital – Mass casualty incident (MCI) 124
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Figure 1: Operational algorithm for mass casualty incident (MCI) [7]<br />
Alert according to<br />
RTLS Notification &<br />
Mobilization<br />
Logistic operations<br />
checklist<br />
• casualty collection point for<br />
severely injured<br />
• access/departure/helicopter<br />
landing pad<br />
• ambulance rendezvous point<br />
• zone coordination<br />
• bed list<br />
• casualty collection point for<br />
those with minor injuries<br />
• patient registration<br />
Checklist of<br />
operational personnel<br />
• emergency<br />
physicians/physicians<br />
• emergency medical<br />
technicians/EMT<br />
• means of transport<br />
• incident command post on site<br />
• technical rescue services (fire<br />
dept.)<br />
• water rescue<br />
• technical relief<br />
• church info service/pastoral<br />
care<br />
Resources checklist<br />
• casualty kits<br />
• medications (BTM)<br />
• protection against the weather<br />
• drinks & food for<br />
uninjured/helpers<br />
• roll-off containers (fire dept.)<br />
• Federal army/federal border<br />
guard containers<br />
Prehospital – Mass casualty incident (MCI)<br />
yes<br />
Approach in consultation<br />
with RTLS<br />
Arrange traffic barriers<br />
Are there sufficient<br />
emergency services<br />
personnel?<br />
X<br />
no<br />
Call via RTLS<br />
for back-up<br />
while en route<br />
Pass on 1st back-up call<br />
Set up Incident Command<br />
Set up local Incident<br />
Command<br />
(with fire dept.& police)<br />
Classify size of accident<br />
incident<br />
Has accident scene been<br />
made safe?<br />
Do zones have to be<br />
demarcated?<br />
X<br />
no<br />
Establish logistic operations<br />
Triage injured<br />
Establish treatment priority<br />
Registration by<br />
Incident Command<br />
Are operational<br />
personnel/resources<br />
adequate?<br />
no<br />
Request supplies<br />
Reorganization<br />
yes<br />
yes<br />
Checklist orientation<br />
accident scene approach<br />
• expected no. of patients?<br />
• hazardous substances?<br />
• size of accident scene?<br />
• emergency services alerted?<br />
• location of incident command<br />
post, police, fire department?<br />
Assign<br />
zone leader &<br />
communication path<br />
Checklist for triaging injured:<br />
Triage Categories I-V<br />
I: Acute life-threatening injuries<br />
1st priority (red)<br />
II: Severely injured/hospitalization<br />
(yellow)<br />
III: Minor injured/later (outpatient)<br />
treatment<br />
(green)<br />
IV: No prospect of survival<br />
(blue)<br />
V: Dead persons (black)<br />
See Algorithm: triage of injured<br />
persons in mass casualty<br />
incident<br />
125
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Missing persons?<br />
Inform police incident<br />
command<br />
Prehospital – Mass casualty incident (MCI)<br />
Sort patients according to<br />
available beds/suitable<br />
hospital<br />
by Incident Command, if<br />
nec. discuss with zone<br />
leader<br />
Patients with acute<br />
surgery indication from<br />
Triage Group I ?<br />
no<br />
Complete triage<br />
Allocate suitable<br />
means of transport<br />
Release transport: Incident<br />
Command<br />
Final registration<br />
Pass on to local police<br />
incident command<br />
Media, tel. no., for relatives<br />
Include feedback of<br />
accompanying emergency<br />
physician/hospital<br />
in evaluation of available<br />
beds<br />
Final search of<br />
accident site with technical<br />
incident command<br />
(police, fire dept.)<br />
Operational documentation<br />
Quality control<br />
Scoring<br />
End of operation<br />
Operational debriefing<br />
(at earliest opportunity)<br />
yes<br />
Immediate transport with emergency<br />
physician/rescue physician<br />
or form convoy<br />
126
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Figure 2: Triage of injured persons at mass casualty incident [7]<br />
yes<br />
A<br />
B<br />
C<br />
D<br />
Triage of injured persons<br />
at mass casualty incident<br />
Does the accident scene<br />
present a hazard?<br />
Commence triage<br />
Able to walk?<br />
no<br />
Fatal injury<br />
no<br />
Central pulse absent?<br />
no<br />
Spontaneous respiration<br />
absent?<br />
no<br />
Respiratory rate above<br />
30/min?<br />
no<br />
Palpable radial pulse?<br />
yes<br />
Spurting haemorrhage?<br />
no<br />
no<br />
Unable to follow simple<br />
commands?<br />
no<br />
Urgent treatment<br />
Casualty collection point<br />
for minor injured<br />
Prehospital – Mass casualty incident (MCI)<br />
II<br />
no<br />
yes<br />
yes<br />
yes<br />
yes<br />
yes<br />
yes<br />
Do NOT approach<br />
yes<br />
no<br />
Possible to release<br />
airways?<br />
Arrest bleeding (compression<br />
bandage)<br />
Casualty collection point<br />
for severely injured<br />
Re-evaluation –<br />
deterioration?<br />
yes<br />
no<br />
No treatment V<br />
Delayed treatment IV<br />
Treat as quickly as possible<br />
Emergency<br />
physician/emergency medical<br />
personnel to treat -<br />
NOT triage physician/local<br />
ES/Incident Command<br />
Acute surgical<br />
indication?<br />
yes<br />
Incident Command to approve<br />
transport<br />
Immediate transportation, if<br />
necessary form convoy<br />
Re-evaluation/re-triage<br />
Transport acc. to urgency I/II<br />
Delayed treatment III<br />
I<br />
no<br />
127
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Literature:<br />
1. Almogy G, Luria T, Richter ED, Pizov R, Bdolah-Abram<br />
T, Mintz Y, Zamir G, Rivkind AI (2005) Can external<br />
signs of trauma guide management? Lessons learned<br />
from suicide bombing attacks in Israel. Arch Surg 140:<br />
390-393<br />
2. American-College-of-Surgeons (1997) Advanced<br />
Trauma Life Support. Chicago<br />
3. Anonymous (1990) Disaster epidemiology. Lancet 336:<br />
845-846<br />
4. Auf der Heide E (1996) Disaster planning, Part II.<br />
Disaster problems, issues, and chall<strong>eng</strong>es identified in<br />
research literature. Emerg Med Clin North Am 14: 453-<br />
480<br />
5. Avitzour M, Libergal M, Assaf J, Adler J, Beyth S,<br />
Mosheiff R, Rubin A, Feigenberg Z, Slatnikovitz R,<br />
Gofin R, Shapira SC (2004) A Multicasualty Event: Outof-hospital<br />
and In-Hospital Organizational Aspects. Acad<br />
Emerg Med 11: 1102-1104<br />
6. Beck A, Bayeff-Filloff M, Bischoff M, Schneider BM,<br />
AG Notfall der <strong>DGU</strong> (2002) Analyse der Inzidenz und<br />
Ursachen von Großschadensereignissen in einem<br />
süddeutschen Rettungsdienstbereich. Unfallchirurg 105:<br />
968-973<br />
7. Beck A, Bayeff-Filloff M, Kanz K.-G, Sauerland S<br />
(2005): Algorithmus für den Massenanfall von<br />
Verletzten an der Unfallstelle: Ein systematisches<br />
Review. Notfall & Rettungsmedizin 8(7): 466-473<br />
8. Beck A, Gebhard F, Kinzl L (2002) Notärztliche<br />
Versorgung des Traumapatienten. Notfall &<br />
Rettungsmedizin 5: 57-71<br />
9. Beck A, Krischak G, Bischoff M (2009)<br />
Wirbelsäulenverletzungen und spinales Trauma. Notfall<br />
& Rettungsmedizin 12(6):469-479<br />
10. Benson M, Koenig KL, Schultz CH (1996) Disaster<br />
triage: START, then SAVE - a new method of dynamic<br />
triage for victims of a catastrophic earthquake. Prehosp<br />
Disast Med 11: 117-124<br />
11. Binder S, Sanderson LM (1987) The role of the<br />
epidemiologist in natural disasters. Ann Emerg Med 16:<br />
1081-1084<br />
12. Bissell RA, Becker BM, Burkle FMJ (1996) Health care<br />
personnel in disaster response. Emerg Med Clin North<br />
Am 14: 267-288<br />
13. Buerk CA, Batdorf JW, Cammack KV, al. e (1982) The<br />
MGM Grand Hotel firs. Lessons learned from a major<br />
disaster. Arch Surg 117: 641<br />
14. Burkle FM, Isaac-Renton J, Beck A, Belgica C-P,<br />
Blatherwick J, Brunet L-A, Hardy N-E, Kendall P, Kunii<br />
O, Lokey W, Sansom G, Stewart R (2001) Application of<br />
international standards to disasters: summary and action<br />
plan. Prehosp Disast Med 16: 36-38 [LoE 2b]<br />
15. Burkle FMJ (1991) Triage of disaster related<br />
neuropsychiatric casualties. Emerg Med Clin North Am<br />
9: 87-105<br />
Prehospital – Mass casualty incident (MCI)<br />
16. Butler FR, Hagemann J, Butler EG (1996) Tactical<br />
combat casualty in special combat operations. Military<br />
Med 161(suppl1): s3<br />
17. Christen HT, Denney JP, Maniscalco PM, Rubin DL<br />
(1999) Terrorism. Part III - Response procedures for<br />
terrorist/tactical violence incidents. J Emerg Med Serv<br />
24: 58-64, 66.<br />
18. Cohen DL, Montalvo MA, Turnbull GP (1994) Medical<br />
support for a major military air show: the RAF<br />
Mildenhall Medical Emergency Support Plan. J Trauma<br />
36: 237-244.<br />
19. Cone DC, MacMillan DS (2005) Commentary: Masscasualty<br />
Triage Systems: A Hint of Science. Acad Emerg<br />
Med 12: 739-741<br />
20. Cowley RA, Myers RA, Gretes AJ (1984) EMS response<br />
to mass casualties. Emerg Med Clin North Am 2: 687-<br />
693<br />
21. Dove DB, Del Guercio LR, Stahl WM, Star LD, Abelson<br />
LC (1982) A metropolitan airport disaster plancoordination<br />
of a multihospital response to provide onsite<br />
resuscitation and stabilization before evacuation. J<br />
Trauma 22: 550-559.<br />
22. Doyle CJ (1990) Mass casualty incident. Integration with<br />
prehospital care. Emerg Med Clin North Am 8: 163-175<br />
23. Eisner ME, Waxman K, Mason GR (1985) Evaluation of<br />
possible patient survival in a mock airplane disaster. Am<br />
J Surg 150: 321-323.<br />
24. Fink A, Kosecoff J, Chassin M, RH. B (1984) Consensus<br />
methods: characteristics and guidelines for use. Am J<br />
Public Health 74: 979-983 [Evidenzbasierte Leitlinie]<br />
25. Frykberg ER (2002) Medical management of disasters<br />
and mass casualties from terrorist bombings: How we<br />
can cope? J Trauma 53: 201-212<br />
26. Frykberg ER (2003) Disaster and Mass Casualty<br />
management: a commentary on the American College of<br />
Surgeons position statement. J Am Coll Surg 197: 857-<br />
859<br />
27. Gans L, Kennedy T (1996) Management of unique<br />
clincal entities in disaster medicine. Emerg Med Clin<br />
North Am 14: 301-326<br />
28. Garner A, Lee A, Harrison K, Schultz CH (2001)<br />
Comparative analysis of multiple-casualty incident triage<br />
algorithms. Ann Emerg Med 38: 541-548<br />
29. Hirshberg A, Stein M, Walden R (1999) Surgical<br />
resource utilization in urban terrorist bombing: a<br />
computer simulation. J Trauma 47: 545-550<br />
30. Hodgetts TJ (1993) Lessons from the Musgrave Park<br />
Hospital bombing. Injury 24: 219-221.<br />
31. Hull D, Grindlinger GA, Hirsch EF, al. e (1985) The<br />
clinical consequences of an industrial aerosol plant<br />
explosion. J Trauma 25: 303<br />
32. Hüls E, Oestern HJ (1999) Die ICE-Katastrophe von<br />
Eschede. Notfall & Rettungsmedizin 6: 327 – 336<br />
128
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
33. Jakobson J (1990) What can we learn from the ferryboat<br />
accident in Zeebrugge? To be well prepared is the best<br />
way to meet disasters. Lakartidningen 87: 827-829.<br />
34. Kanz KG, Eitel F, Waldner H, Schweiberer L (1994)<br />
Entwicklung von klinischen Algorithmen für die<br />
Qualitätssicherung in der <strong>Polytrauma</strong>versorgung.<br />
Unfallchirurg 97: 303-307<br />
35. Kanz KG, Sturm J, Mutschler W, Arbeitsgemeinschaft<br />
Notfallmedizin der <strong>DGU</strong> (2002) Algorithmus für die<br />
präklinische Versorgung bei <strong>Polytrauma</strong>. Unfallchirurg<br />
105: 1007-1014<br />
36. Klein JS, Weigelt JA (1991) Disaster management.<br />
Lessons learned. Surg Clin North Am 71: 257-266.<br />
37. Koenig KL, Dinerman N, Kuehl AE (1996) Disaster<br />
nomenclature - a functional impact approach: the PICE<br />
system. Acad Emerg Med 3: 723-727<br />
38. Koscheyev VS, Leon GR, Greaves IA (1997) Lessons<br />
learned and unsolved public health problems after largescale<br />
disasters. Prehospital Disaster Med 12: 120-131.<br />
39. Leibovici D, Gofrit O, Stein M, al. e (1996) Blast<br />
injuries: bus vs open-air bombings - a comparative study<br />
of injuries in survivors of open-air and confined-space<br />
explosions. J Trauma 41: 1030<br />
40. Leonard RB, Teitelman U (1991) Manmade disasters.<br />
Crit Care Clin 7: 293<br />
41. Lewis CB, Aghababian RV (1996) Disaster planning part<br />
1. Overview of hospital and emergency department<br />
planning for internal and external disasters. Emerg Med<br />
Clin North Am 14: 439<br />
42. Lewis FR, Trunkey DD, Steele MR (1980) Autopsy of a<br />
disaster. J Trauma 20: 861<br />
43. Mahoney LE, Reutershan TP (1987) Catastrophic<br />
disasters and the design of disaster medical care systems.<br />
Ann Emerg Med 16: 1085-1091<br />
44. Mahoney LE, Whiteside DF, Belue HE, Belue HE,<br />
Mortisugu KP, Esch VH (1987) Disaster medical<br />
assistance teams. Ann Emerg Med 16: 354-358<br />
45. Mallonee S, Shariat S, Stennies G, Waxweiler R, Hogan<br />
D, Jordan FB (1996) Physical injuries and fatalities from<br />
the Oklahoma City bombing. JAMA 276: 382-387<br />
46. Martin TE (1990) The Ramstein airshow disaster. J R<br />
Army Med Corps 136: 19-26.<br />
47. Matussek M, Beste R, Mascolo G (2005) Rekruten des<br />
Irrsinns. Der Spiegel 28: 20-27<br />
48. Maxwell -CI, Strohl GR, Jr. (1985) The best way to<br />
prepare for the worst. Osteopath Hosp Leadersh 29: 15-<br />
16<br />
49. Morris GP (1982) The Kenner airliner disaster. A 727<br />
falls into a New Orleans suburb. J Emerg Med Serv<br />
JEMS 7: 58-65.<br />
50. Nancekievil DG (1989) Disaster management. Practice<br />
makes perfect. BMJ 298: 477<br />
51. Nania J, Bruva TE (1982) In the wake of Mount St<br />
Helens. Ann Emerg Med 11: 184<br />
52. Nechaev EA, Malakhov SF, Dedushkin VS, Emelianov<br />
VA, Porembskii Ia O (1989) The characteristics of the<br />
medical evacuation measures in a railroad accident in<br />
Bashkiria. Voen Med Zh 12-17.<br />
53. Nechaev EA, Reznik MI (1990) The methodological<br />
basis for a medical system in extreme situations. Voen<br />
Med Zh 6: 5-10.<br />
54. Neugebauer E (1999) Development of a consensus<br />
protocol - a new approach to improve study design. Eur J<br />
Surg (Suppl) 584: 7-11<br />
55. Nicholas RA, Oberheide JE (1988) EMS response to a<br />
ski lift disaster in the Colorado montains. J Trauma 28:<br />
672<br />
56. Noji EK (1991) Natural Disasters. Crit Care Clin 7: 271-<br />
292<br />
57. Noji EK (1996) Disaster epidemiology. Emerg Med Clin<br />
North Am 14: 289-300<br />
58. Noji EK, Kelen GD, Armenian HK, Oganessian A, Jones<br />
NP, Sivertson KT (1990) The 1988 earthquake in Soviet<br />
Armenia. A case study. Ann Emerg Med 19: 891-897<br />
59. O'Hickey SP, Pickering CA, Jones PE, Evans JD (1987)<br />
Manchester air disaster. Br Med J (Clin Res Ed) 294:<br />
1663-1667.<br />
60. Rivkind A, Barach P, Israeli A, Berdugo M, Richter ED<br />
(1997) Emergency preparedness and response in Israel<br />
during the Gulf War. Ann Emerg Med 30: 513-521.<br />
61. Rosemurgy AS, Norris PA, Olson SM, al. e (1993) Prehospital<br />
cardiac arrest: the cost of futility. J Trauma 35:<br />
468<br />
62. Roth PB, Vogel A, Key G, Hall D, Stockhoff CT (1991)<br />
The St Croix disaster and the National Disaster Medical<br />
System. Ann Emerg Med 20: 391-395<br />
63. Ruppert M, Widmann JH, Schneider K, Schmidbauer S,<br />
Reith MW, Lackner CK, Schweiberer L (1998)<br />
Oktoberfest-Triage-Evaluationsstudie 1997 (OTES ´97):<br />
Prospektive Studie zur Sichtungsqualität von<br />
Notfallpatienten unter katastrophenmedizinischen<br />
Gesichtspunkten. Notfall & Rettungsmedizin 1: 268-278<br />
64. Rutherford WH (1988) An analysis of civil aircrash<br />
statistics 1977-86 for the purposes of planning disaster<br />
exercises. Injury 19: 384-388.<br />
65. Sacco WJ, Navin DM, Fiedler KE, K. WIR, Long WB,<br />
Buckman Jr RF (2005) Precise Formulation and<br />
Evidence-based Application of Resource-constrained<br />
Triage. Acad Emerg Med 12: 759-770<br />
66. Sackett DL, Richardson WS, Rosenberg W, Haynes RB<br />
(1997) Evidence-based medicine: How to practice and<br />
teach EBM. Churchill Livingstone, London/UK<br />
67. Sampalis JS, Tamim H, Nikolis A, Lavoie A, Williams JI<br />
(1996) Predictive validity and internal consistency of the<br />
pre-hospital index measured on-site by physicians. Accid<br />
Anal Prev 28: 675-684<br />
68. Sefrin P, Weidringer JW, Weiss W (2003)<br />
Sichtungskategorien und deren Dokumentation. Einigung<br />
von Experten aus Deutschland sowie einigen<br />
europäischen Staaten. Dtsch Ärztebl 100 (Heft 2031-<br />
2032): A 2057-2058<br />
69. Solieri KT (1990) Impressions: the crash of Avianca<br />
flight 052. J Emerg Nurs 16: 307-308.<br />
70. Sopher LV, Petersen R, Talbott M (1990) The crash of<br />
Flight 232: an emergency care perspective. J Emerg Nurs<br />
16: 61A-66A.<br />
71. Steedman DJ, Gordon MW, Cusack S, White M,<br />
Robertson CE, Little K (1991) Lessons for mobile<br />
medical teams following the Lockerbie and Guthrie<br />
Street disasters. Injury 22: 215-218.<br />
Prehospital – Mass casualty incident (MCI) 129
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
72. Stratmann D (2003) Strategien des Rettungsdienstes -<br />
Konsequenzen nach dem 11. September. Notfall &<br />
Rettungsmedizin 6: 102-106<br />
73. Streger MR (1998) Prehospital triage. Emerg Med Serv<br />
27: 21, 23-27<br />
74. Waeckerle JF (1991) Disaster planning and response. N<br />
Engl J Med 324: 815-821<br />
75. Washington B, Wilson RF, Steiger Z, al. e (1985)<br />
Emergency thoracotomy: a four-year review. Ann Thorac<br />
Surg 40: 188<br />
76. Woltering HP, Schneider BM (2002) Das Unglück von<br />
Enschede. Unfallchirurg 105: 961-967<br />
Prehospital – Mass casualty incident (MCI) 130
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2 Emergency room<br />
2.1 Introduction<br />
How would you treat?<br />
You are called to the emergency room one winter’s night. As this is your first shift in trauma<br />
surgery, you’re feeling quite nervous when you enter the casualty department. You reach the<br />
preheated emergency room and shortly afterwards receive a handover from the emergency<br />
physician. He reports that a 42-year-old patient has had a motorbike accident. The initial GCS at<br />
the accident scene was 13, the right chest wall has marked crepitations, peripheral saturation is<br />
85% during spontaneous breathing and, in addition, the patient is complaining of an intense<br />
tenderness in the right upper abdomen. The pelvis is stable and he has not noticed any extremity<br />
injuries. After prehospital anesthesia induction and oral intubation, peripheral saturation has<br />
risen to over 95%. Due to adequate oxygenation and normal capnometry, the insertion of a chest<br />
drain was dispensed with for the short transport journey. The patient is now intubated and<br />
ventilated and has stable circulation (110/80 mmHg, pulse 85). However, measurement of<br />
peripheral saturation yields a value of 90%. The patient is not fully undressed. A cervical collar<br />
has been applied. You look up at the wall in your emergency room and recognize an algorithm<br />
there which you are familiar with, which you recently learnt on a polytrauma course:<br />
A Airway with immobilization of the cervical spine<br />
B Breathing/Ventilation<br />
C Circulation<br />
D Disability/Neurology<br />
E Expose – Environment/Undress - Keep Warm<br />
Your confidence grows and you immediately start with the “primary survey and treatment” in<br />
the emergency room. You note that the cervical collar is sitting in the correct place. Under “B”,<br />
the on-duty anesthesiologist notices a weakened breath sound in the right chest, and peripheral<br />
saturation is now 83%. You have a brief discussion with him and decide to insert a chest drain<br />
via a mini-thoracotomy. Air is released and approximately 400 ml of blood. You check the<br />
success of your intervention and notice an increase in saturation to 99%. You are still nervous<br />
but know what you have to do next under “C”. Meanwhile, a central venous catheter and arterial<br />
access have been placed. Blood pressure is 110/80 mmHg, heart rate 85/min. Ultrasonography of<br />
the abdomen (FAST) detects free fluid in the Douglas cavity and around the liver, the on-duty<br />
radiologist estimates the volume to be approximately 500 ml. You do not detect any relevant<br />
bleeding to the outside. After alerting the visceral surgeon, the neurosurgeon has meanwhile<br />
checked the pupils under point “D”. After he has established that they are narrow but lightreactive,<br />
you start “E” and examine the now fully-undressed patient. A full-body CT scan is<br />
conducted because of the mechanism of injury. The laboratory values show a hemoglobin value<br />
of 11.5 g/dl, INR of 90%, and a base excess of -1.5 mmol/l. The patient has received a total of<br />
1,500 ml fluid.<br />
Emergency room - Introduction 131
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The visceral surgeon who has meanwhile arrived confirms the ultrasonography finding. The fullbody<br />
CT scan shows a severe pulmonary contusion on the right and a liver laceration without<br />
active bleeding. You come to a consensual decision to proceed as follows: conservative<br />
treatment of the abdominal injury and direct transfer of the patient to an intensive care unit.<br />
The aim of this “emergency room” guideline section<br />
The case presented at the start shows the importance of a logical and clear algorithm in an<br />
extreme situation. The sequence of actions in the emergency room must be checked against the<br />
evidence from as complete a literature base as possible. An expert committee examines the<br />
evidence levels, resulting in the grades of recommendation, which can strongly influence the<br />
sequence of actions. Thus, the aim of this guideline section is, on the one hand, to create clear,<br />
sustainable process sequences which, on the other hand, must contribute towards further<br />
improving care of the critically injured. For it is precisely the scientific reproducibility of the<br />
clinician’s actions in the emergency room that form the basis of reproducible, valid treatment<br />
and, in collaboration with the various medical disciplines, effectuate the parallelizing of<br />
processes and thus an improvement in the treatment.<br />
Special notes:<br />
A guideline does not claim to be able to treat every situation conclusively; this also applies to the<br />
emergency room. Not infrequently, the generation of clear recommendations is hampered by the<br />
lack of studies with a high evidence level. Clear views are expressed on this issue in the<br />
corresponding background texts to each chapter. In addition, various statements are subject to a<br />
time dynamic. This is accommodated by conducting a re-evaluation after 2 years. Nevertheless,<br />
there is a need to describe important correlations in detail.<br />
Managing a multiply injured patient in the emergency room places a great demand on the<br />
treatment process because of the acuteness of the events and the large number of treating<br />
physicians from different specialties. As with all complex sequences of actions, errors do occur.<br />
But not every error need have a negative influence on the quality of treatment [1]. However, an<br />
accumulation of errors can occasionally have fatal consequences for the patient. For this reason,<br />
the basis of rational quality management lies in calmly working through the complications, and<br />
this approach should be firmly established within a quality circle in hospitals which are involved<br />
in the care of the critically injured [5]. Care in the emergency room should be quite rigorously<br />
characterized here by prescribed sequences and a common language with prehospital and<br />
emergency room care merging together seamlessly. Course strategies, such as depicted by<br />
Prehospital Trauma Life Support ® (PHTLS ® ) for prehospital care and Advanced Trauma Life<br />
Support® (ATLS®) or European Trauma Course® (ETC®) for clinical care, can automate and<br />
thus improve this process through a clear hierarchy of treatment sequences and a common<br />
language [3, 4]. It is important that every hospital has an emergency room algorithm and that all<br />
those potentially involved are familiar with it.<br />
Working groups and quality circles have been successfully introduced in many hospitals and<br />
they regularly evaluate and improve their own emergency room strategy based on actual cases.<br />
Both the leadership of such quality circles and the question of responsibility in the emergency<br />
room are issues that are the subject of heated debate in professional associations. Because severe<br />
Emergency room - Introduction 132
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
injury is part of the core competence in trauma surgery, it may be legitimate for physicians<br />
qualified in this discipline to be in charge of both the quality circles and treatment in the<br />
emergency room [5]. However, it must not be forgotten that there are also other operational<br />
strategies in emergency room care [6, 7, 9]. For this reason, during the development of the<br />
guideline, this sensitive topic has been accommodated in various places in the background text as<br />
even strategies without a team leader are feasible involving just a multidisciplinary team working<br />
together. However, it should be discussed upfront who takes over responsibility in which<br />
situation in order to be prepared especially for medico-legal questions [8].<br />
Emergency room - Introduction 133
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Ruchholtz S, Nast-Kolb D, Waydhas C, Betz P,<br />
Schweiberer L (1994) Frühletalität beim <strong>Polytrauma</strong> –<br />
eine kritische Analyse vermeidbarer Fehler.<br />
Unfallchirurg 97: 285–291<br />
2. Ertel W, Trentz O (1997) Neue diagnostische Strategien<br />
beim <strong>Polytrauma</strong>. Chirurg 68: 1071–1075<br />
3. Sturm JA, Lackner CK, Bouillon B, Seekamp A,<br />
Mutschler WE (2002) Advanced Trauma Life Support<br />
(ATLS ® ) und Systematic Prehospital Life Support<br />
(SPLS). Unfallchirurg 105: 1027–1032<br />
4. Advanced Trauma Life Support, 8th Edition, The<br />
Evidence for Change John B. Kortbeek, MD, FRCSC,<br />
FACS, Saud A. Al Turki, MD, FRCS, ODTS, FACA,<br />
FACS, Jameel Ali, MD, MMedEd, FRCS, FACS et.<br />
al. J Trauma. 2008;64:1638 –1650<br />
5. Frink M, Probst C, Krettek C, Pape HC (2007)<br />
Klinisches <strong>Polytrauma</strong>-Management im Schockraum<br />
– Was muss und kann der Unfallchirurg leisten?<br />
Zentralbl Chir 132:49–53<br />
6. Bergs EA, Rutten FL, Tadros T et al. (2005)<br />
Communication during trauma resuscitation: do we<br />
know what is happening? Injury 36:905–911<br />
7. Cummings GE, Mayes DC (2007) A comparative study<br />
of designated Trauma Team Leaders on trauma<br />
patient survival and emergency department l<strong>eng</strong>th-ofstay.<br />
CJEM 9:105–110<br />
8. Bouillon B (2009) Brauchen wir wirklich keinen<br />
„trauma leader” im Schockraum? 112:400–401<br />
9. Wurmb T, Balling H, Frühwald P, et al.<br />
<strong>Polytrauma</strong>management im Wandel. Zeitanalyse<br />
neuer Strategien für die Schockraumversorgung.<br />
Unfallchirurg 2009; 112: 390-399<br />
Emergency room - Introduction 134
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.2 The emergency room - personnel and equipment resources<br />
The annual number of multiply injured patients in Germany is approximately 32,000-38,000 [13,<br />
30, 39, 53]. In the Federal Republic of Germany, there are currently approximately 700-800<br />
hospitals available for the initial treatment of these patients (emergency room treatment).<br />
Although this figure would seem to indicate demand is adequately covered, it should be<br />
emphasized that a) not all hospitals have sufficient personnel or structural requirements or the<br />
specialist competence to care for these patients, b) there are still regions in Germany without<br />
sufficient provision of hospitals for polytrauma treatment, and c) fully equipped hospitals cannot<br />
always be reached within acceptable time periods, particularly at night if rescue helicopters are<br />
not allowed to take off due to the existing nighttime flying ban or because of capacity problems.<br />
The introduction of regionalized trauma centers with defined standards in the management of<br />
trauma patients resulted in a reduction in the rate of avoidable deaths in the United States [8, 54].<br />
To further improve polytrauma management in Germany, and make it more consistent across the<br />
whole country, it seems logical to define the requirements for the care of severely injured<br />
patients in terms of structure and personnel, and to standardize them to the maximum possible<br />
extent.<br />
The <strong>DGU</strong> Trauma Network Project D has been initiated to implement this requirement. In the<br />
participating hospitals, which already number approximately 800 (as at April 2010), the <strong>DGU</strong><br />
Trauma Network D is coordinating the implementation of the written contents of the <strong>DGU</strong>’s<br />
White Paper on the management of the severely injured [8, 54].<br />
Emergency room team<br />
Key recommendation:<br />
In polytrauma management, fixed teams (known as emergency room teams)<br />
must work according to pre-structured plans and/or have completed special<br />
training.<br />
Explanation:<br />
GoR A<br />
To achieve coordinated, balanced cooperation among various staff in polytrauma management, it<br />
is internationally commonplace to put together fixed teams for emergency room care, which<br />
work according to pre-structured plans and/or have completed special training (particularly<br />
ATLS ® , ETC, Definitive Surgical Trauma Care [DSTC]) [14a] [4, 47, 49, 51, 56]. Various<br />
studies have found that this emergency room strategy has clinical advantages [13, 30, 39, 53].<br />
Ruchholtz et al. showed, for example, that an interdisciplinary team, integrated into a quality<br />
management (QM) system and acting on the basis of internal hospital guidelines and discussions,<br />
works very efficiently under joint surgical and anesthesiologic management [8, 54].<br />
Key recommendation:<br />
Emergency room – Personnel and equipment resources 135
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The basic emergency room team must consist of at least 3 physicians (2<br />
surgeons, 1 anesthesiologist), with at least 1 anesthesiologist and 1 surgeon<br />
having attained specialist grade.<br />
Explanation:<br />
GoR A<br />
There are no validated studies on the composition of the emergency room team so that<br />
statements on team composition can only relate to how these are predominantly formed<br />
internationally. So, the question as to which specialties should be primarily represented in the<br />
emergency room team often depends on local conditions [6, 9, 11, 12, 14, 20–25, 27, 31–33, 38,<br />
41, 45, 50]. On the other hand, individual studies from other countries show that a large<br />
proportion of multiply injured patients can be effectively managed even with only 2 physicians<br />
[3, 7, 12]. Depending on the injury pattern/severity, however, the team initially comprising at<br />
least 2-3 persons will then have to be supplemented with more colleagues [29, 40, 46]. In<br />
screening the international literature, it emerged that almost all teams worldwide had either<br />
special trauma surgeons of different training levels or general surgeons with (many years’)<br />
trauma experience, also with different training levels.<br />
Accordingly, the cited team composition of at least 3 physicians can only serve as a minimum<br />
number and the team should be enlarged by one or two other 1-2 physicians (e.g., radiologist,<br />
neurosurgeon) depending on the size and care level of the hospital and the severely injured<br />
workload. In any event, the management of the severely injured must be undertaken by a<br />
qualified surgeon whose minimum qualification must be at the level of a specialist in<br />
general/visceral surgery or a specialist in orthopedics and trauma surgery (regional medical<br />
association (Landesärztekammer) [LÄK], Rules for Specialist Training for Physicians, as at<br />
07/2009). The treating anesthesiologist must have the minimum qualification of specialist.<br />
The function of and necessity for a “trauma leader” in the emergency room is a matter of much<br />
controversy in the literature. Even in the consensus conferences during the development of the<br />
<strong>S3</strong> guideline, there was intense, heated debate about the necessity for a “team leader” and about<br />
what his duties should be and to which specific specialist area he should be assigned. A<br />
structured literature search was conducted on these issues during the guideline development. In<br />
terms of patient survival, no credible evidence was identified for the superiority of one particular<br />
management structure in the emergency room (“trauma leader” versus “interdisciplinary<br />
management group”) or for the assignment of a “trauma leader” to one particular specialist area<br />
(trauma surgery, surgery versus anesthesia).<br />
Hoff et al. [21] showed that bringing in a team leader (known as a command physician)<br />
improved the care and treatment pathway [21]. Alberts et al. also found evidence of improved<br />
treatment pathways and treatment results after the strategy of “trauma leader” had been<br />
introduced [1]. Depending on the tasks - including patient handover, examining the patient,<br />
carrying out and monitoring therapeutic and diagnostic measures, consulting with other specialist<br />
disciplines, coordinating all medical and technical team members, preparing examinations<br />
following on from emergency room care, contacting relatives after completion - that the “trauma<br />
leader” needs to be able to take on in principle, this task must either be carried out on an<br />
Emergency room – Personnel and equipment resources 136
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
interdisciplinary basis or by a “team leader” experienced in the management of multiply injured<br />
patients. In an interdisciplinary process even closer attention should be paid that the treatment<br />
pathways are agreed and consensual to avoid any time delays [18, 21, 37, 50].<br />
According to the recommendations of the American College of Surgeons Committee on Trauma<br />
(ACS COT), a qualified surgeon must take over the team leadership [8, 54]. In a large<br />
comparative study of over 1,000 patients, there were almost identical case fatality rates and<br />
l<strong>eng</strong>th-of-hospital-stays irrespective of whether 1 out of 4 trauma surgeons or 1 out of 12 general<br />
surgeons, albeit with trauma surgery knowledge, were responsible for the emergency room [41].<br />
In a comparison between “trauma surgeons” and “emergency physicians”, Khetarpal showed that<br />
under traumatologic leadership the management times and the start of surgery were shorter, but<br />
without this apparently having had an effect on the treatment outcome [8, 54]. In a study by<br />
Sugrue et al. it is confirmed that no serious implications arise from who leads the ER team so<br />
long as he has adequate experience, expertise, and training [8, 54]. In many places, trauma teams<br />
have also been led very effectively, cooperatively, and successfully by anesthesiologists for<br />
many years.<br />
High specialization in the individual specialist disciplines is particularly taken into account in<br />
interdisciplinary leadership models. Here, each specialist discipline has predefined tasks and is in<br />
charge of the devolved tasks at defined points in time within emergency room management. The<br />
leadership group, comprising anesthesiology, radiology, surgery, and trauma surgery (in<br />
alphabetical order), confers at fixed times and in addition to these if the situations in question<br />
demand it [57].<br />
Notwithstanding, the experts argue for clear rules on responsibilities aligned to local conditions,<br />
agreements, and competences. Team leadership should be encouraged, irrespective of which<br />
specialist discipline it originates from or whether consisting of one person or a leadership group.<br />
The task of the team leadership is to collect and inquire about the findings of the individual<br />
specialized team members and to effectuate decision-making. The team leadership heads<br />
communication and establishes further diagnostic and treatment steps in agreement with the<br />
team. Within the quality circles of the establishment, the functions and qualifications of the<br />
“team leader” and of the “interdisciplinary leadership group” should be established in the<br />
emergency room. Ideally, after agreement, the “best” (one or more persons) must take on the<br />
task of “trauma leader” and “interdisciplinary leadership group”. In particular, rules must be<br />
made for the following points, which must stand up to a “best practice jurisdiction” inspection.<br />
� Responsibility<br />
� Leadership structure for coordination, communication and decision-making within<br />
the context of emergency room management<br />
Emergency room – Personnel and equipment resources 137
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
� Monitoring and ensuring quality (implementing quality circles; identifying quality<br />
and patient safety indicators; continuous monitoring of structures, processes, and<br />
results)<br />
Key recommendation:<br />
Trauma centers must have provision for enlarging emergency room teams GoR A<br />
Explanation:<br />
The size and composition of the enlarged emergency room team is determined by the care level<br />
of the hospital concerned and the corresponding injury severity to be expected there as well as by<br />
the maximum number of surgical interventions that can be performed there if necessary (White<br />
Paper). Accordingly, transboundary trauma centers, being the highest care level, should contain<br />
all specialist disciplines which perform emergency care. Table 11 gives an overview. A qualified<br />
specialist (specialist physician) from the department concerned must be able to get there within<br />
20-30 minutes (see below).<br />
Emergency room – Personnel and equipment resources 138
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
Attending physicians necessary for subsequent care must be present within<br />
20-30 minutes of being alerted.<br />
Explanation:<br />
GoR A<br />
A comparative study of hospitals found that it was not absolutely necessary for the trauma<br />
surgeon to be available in the hospital all hours provided the distance to the hospital was not<br />
greater than 15 minutes and a resident was already in the hospital [11]. Allen et al. and Helling et<br />
al. give 20 minutes as the limit here [3, 19]. In contrast, Luchette et al. and also Cornwell et al.<br />
found “in-house” readiness to be an advantage [9, 33] although Luchette showed that only the<br />
diagnosis and start of surgery was speeded up if an attending physician was initially present,<br />
both the period of intensive care and mortality of patients with severe thoraco-abdominal or head<br />
injuries remaining unaffected [13, 30, 39, 53].<br />
In a comparison over several years, figures from the Trauma Audit and Research Network<br />
(TARN) (England & Wales) confirm that the increased presence of a qualified<br />
specialist/attending physician (60% versus 32%) contributes to significant reductions in<br />
mortality [28]. Wyatt et al. also found evidence that severely injured patients in Scotland<br />
(n = 1,427; ISS > 15) were treated faster and were more likely to survive if they were treated by<br />
an experienced attending physician/consultant instead of a resident [58]. In the ACS COT<br />
recommendations, the presence of an attending surgeon is not mandatory, provided a senior<br />
surgical resident is directly involved in the management of the severely injured [8, 54]. In a<br />
retrospective analysis over a period of 10 years, Helling et al. showed that no relevant<br />
improvement in treatment outcomes are achieved by the initial presence of an attending<br />
physician [35, 39, 52]. For patients with penetrating injuries, in shock, with a GCS < 9 or ISS<br />
≥ 26, there was no difference in the care quality with regard to mortality, start of surgery,<br />
complications or l<strong>eng</strong>th of treatment in the intensive care unit if the on-duty physician<br />
participated in the subsequent care within 20 minutes (“on call”). Only the initial care period and<br />
the total l<strong>eng</strong>th of stay in hospital were less for blunt trauma if the attending physician could be<br />
in the emergency room (“in-house”) immediately. These results are confirmed to a large extent<br />
by Porter et al., Demarest et al., and Fulda et al. [11, 16, 43].<br />
Overall, it can be concluded from these results that an attending physician does not have to be<br />
present immediately at the start of emergency room care if a surgeon qualified in the care of the<br />
severely injured (specialist grade and if applicable ATLS ® and ETC certified) initially carries out<br />
the care of the injured. However, it should be ensured that an attending physician can be reached<br />
quickly.<br />
A thoracic surgeon, ophthalmologist, maxillofacial surgeon and otolaryngologist (ENT) should<br />
be reachable within 20 minutes [18, 27, 34, 42]. According to Albrink et al. [2], the thoracic<br />
surgeon should be brought in as early as possible particularly in the case of aortic lesions.<br />
Emergency room – Personnel and equipment resources 139
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
It seems that a pediatric surgeon is also not necessary in the basic ER team. The studies of<br />
Knudson et al. [26], Fortune et al. [15], Nakayama et al. [36], Rhodes et al. [44], Bensard et al.<br />
[5], D’Amelio et al. [10], Stauffer [48] and Hall et al. [17] were unable to find evidence of any<br />
improvement in treatment outcome through the involvement of special pediatric surgeons.<br />
An anesthesiologist necessary for the subsequent care of the multiply injured patient must also<br />
be present within 20–30 minutes of being alerted.<br />
Key recommendation:<br />
The size of the emergency room should be 25-50 m 2 (per patient to be treated). GoR B<br />
Explanation:<br />
The information given is based on a) the recommendations for initial management of the patient<br />
with traumatic brain injury and multiple injuries of the individual working group and circles of<br />
the German Society of Anesthesiology and Intensive Care Medicine (DGAI), the German<br />
Society for Neurosurgery (DGNC), and the German Interdisciplinary Association of Intensive<br />
Care and Emergency Medicine (DIVI). They recommend a minimum size per treatment unit of<br />
25 m 2 [55].<br />
In addition, the room size can also be calculated b) using the specifications of the Technical<br />
Rules for Workplaces (Arbeitsstätten-Richtlinie) (ASR), the Workplaces Ordinance<br />
(Arbeitsstättenverordnung) (ArbStättV, 2nd section; room dimensions, air space), the German Xray<br />
Ordinance (Röntgenverordnung) (RöV), and the Technical Rules for Hazardous Substances<br />
(Technische Regeln für Gefahrenstoffe) (TRGS). It specifies that 18 m 3 of breathable air per<br />
person carrying out heavy physical activity and 15 m 3 for average physical activity must be<br />
ensured in rooms with natural ventilation or air conditioning; 10 m 3 is estimated for every<br />
additional person who is only temporarily there. Thus, a room volume of about 75-135 m 3 would<br />
be required if there were 5-9 persons present (3-5 physicians, 1 medical radiologic technologist,<br />
1-2 trauma surgery nurses, anesthesiology nurses) and the assumption of average physical work<br />
(lead aprons worn during care). With a ceiling height of 3.2 m, this corresponds to a room size of<br />
approximately 23-42 m 2 . Not included in the calculation is the loss of space through anesthesia<br />
and ultrasonography equipment, work surfaces, patient stretcher, cupboards and similar so that a<br />
total of 25-50 m 2 per unit should be the starting point. If it is possible to treat a maximum of 2<br />
severely injured patients simultaneously, the area is enlarged accordingly. Section 38 (2) of the<br />
German Workplaces Ordinance of 1986 specifies a clear door width of at least 1.2 m with a door<br />
height of 2 m for paramedic and first aid rooms.<br />
Emergency room – Personnel and equipment resources 140
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
The emergency room, ambulance entrance, radiology department, and<br />
surgery department should be in the same building. The helicopter landing<br />
pad should be located in the hospital grounds.<br />
Explanation:<br />
GoR B<br />
All screening tests necessary for emergency surgery (laparotomy, thoracotomy, external<br />
fixator/pelvic C-clamp) must be kept in readiness.<br />
Table 11: Composition and presence of specialist grade physicians in the enlarged emergency<br />
room team in relation to the care level<br />
Specialist Department<br />
Transboundary<br />
TC<br />
Regional TC Local TC<br />
Trauma surgery X X X<br />
General or visceral surgery X X X<br />
Anesthesia X X X<br />
Radiology X X X<br />
Vascular surgery X * –<br />
Neurosurgery X * –<br />
Cardiac or thoracic surgery * * –<br />
Plastic surgery * * –<br />
Ophthalmology * * –<br />
ENT * * –<br />
OMFS * * –<br />
Pediatrics or pediatric surgery * * –<br />
Gynecology * * –<br />
Urology * * –<br />
X: required –: not required *: optional<br />
Emergency room – Personnel and equipment resources 141
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Alberts Ka, Bellander Bm, Modin G (1999) Improved<br />
trauma care after reorganisation: a retrospective<br />
analysis. Eur J Surg 165:426-430 [LoE 4]<br />
2. Albrink Mh, Rodriguez E, England Gj et al. (1994)<br />
Importance of designated thoracic trauma surgeons in<br />
the management of traumatic aortic transection. South<br />
Med J 87:497-501 [LoE 2b]<br />
3. Allen Dm, Hicks G, Bota Gw (1998) Outcomes after<br />
severe trauma at a northern Canadian regional trauma<br />
centre. Can J Surg 41:53-58 [LoE 2b]<br />
4. Aprahamian C, Wallace Jr, Bergstein Jm et al. (1993)<br />
Characteristics of trauma centers and trauma<br />
surgeons. J Trauma 35:562-568<br />
5. Bensard Dd, Mcintyre Rc, Jr., Moore Ee et al. (1994)<br />
A critical analysis of acutely injured children<br />
managed in an adult level I trauma center. J Pediatr<br />
Surg 29:11-18<br />
5a. Bouillon B (2009) Brauchen wir wirklich keinen<br />
„trauma leader“ im Schockraum? Unfallchirurg 112:<br />
400-401<br />
6. Brennan R, Cohen Ss, Chambers Ja et al. (1994) The<br />
OR suite as a unique trauma resuscitation bay. AORN<br />
J 60:576-577, 580-574<br />
7. Carmody Ic, Romero J, Velmahos Gc (2002) Day for<br />
night: should we staff a trauma center like a<br />
nightclub? Am Surg 68:1048-1051 [LoE 4]<br />
8. Champion Hr, Sacco Wj, Copes Ws (1992)<br />
Improvement in outcome from trauma center care.<br />
Arch Surg 127:333-338<br />
9. Cornwell Ee, 3rd, Chang Dc, Phillips J et al. (2003)<br />
Enhanced trauma program commitment at a level I<br />
trauma center: effect on the process and outcome of<br />
care. Arch Surg 138:838-843 [LoE 4]<br />
10. D'amelio Lf, Hammond Js, Thomasseau J et al. (1995)<br />
"Adult" trauma surgeons with pediatric commitment:<br />
a logical solution to the pediatric trauma manpower<br />
problem. Am Surg 61:968-974<br />
11. Demarest Gb, Scannell G, Sanchez K et al. (1999) Inhouse<br />
versus on-call attending trauma surgeons at<br />
comparable level I trauma centers: a prospective<br />
study. J Trauma 46:535-542 [LoE 4]<br />
12. Deo Sd, Knottenbelt Jd, Peden Mm (1997) Evaluation<br />
of a small trauma team for major resuscitation. Injury<br />
28:633-637 [LoE 4]<br />
13. Dodek P, Herrick R, Phang Pt (2000) Initial<br />
management of trauma by a trauma team: effect on<br />
timeliness of care in a teaching hospital. Am J Med<br />
Qual 15:3-8 [LoE 2b]<br />
14. Eastes Ls, Norton R, Brand D et al. (2001) Outcomes<br />
of patients using a tiered trauma response protocol. J<br />
Trauma 50:908-913<br />
14a. Flohe S, Nast-Kolb D (2009) Chirurgisches<br />
Management vital bedrohlicher Verletzungen<br />
Unfallchirurg 112: 854-859.<br />
15. Fortune Jb, Sanchez J, Graca L et al. (1992) A<br />
pediatric trauma center without a pediatric surgeon: a<br />
four-year outcome analysis. J Trauma 33:130-139<br />
16. Fulda Gj, Tinkoff Gh, Giberson F et al. (2002) Inhouse<br />
trauma surgeons do not decrease mortality in a<br />
level I trauma center. J Trauma 53:494-502<br />
17. Hall Jr, Reyes Hm, Meller Jl et al. (1996) The<br />
outcome for children with blunt trauma is best at a<br />
pediatric trauma center. J Pediatr Surg 31:72-76;<br />
discussion 76-77<br />
18. Hartmann J, Gabram S, Jacobs L et al. (1996) A<br />
model for an integrated emergency medicine/trauma<br />
service. Acad Emerg Med 3:1136-1139 [LoE 5]<br />
19. Helling Ts, Nelson Pw, Shook Jw et al. (2003) The<br />
presence of in-house attending trauma surgeons does<br />
not improve management or outcome of critically<br />
injured patients. J Trauma 55:20-25 [LoE 2b]<br />
20. Highley Da (1994) Review of the composition and use<br />
of trauma teams within the Trent Region. J Accid<br />
Emerg Med 11:183-185<br />
21. Hoff Ws, Reilly Pm, Rotondo Mf et al. (1997) The<br />
importance of the command-physician in trauma<br />
resuscitation. J Trauma 43:772-777 [LoE 2b]<br />
22. Jacobs Ia, Kelly K, Valenziano C et al. (2000) Cost<br />
savings associated with changes in routine laboratory<br />
tests ordered for victims of trauma. Am Surg 66:579-<br />
584<br />
23. Kaplan Lj, Santora Ta, Blank-Reid Ca et al. (1997)<br />
Improved emergency department efficiency with a<br />
three-tier trauma triage system. Injury 28:449-453<br />
24. Kazemi Ar, Nayeem N (1997) The existence and<br />
composition of trauma teams in the UK. Injury<br />
28:119-121<br />
25. Khetarpal S, Steinbrunn Bs, Mcgonigal Md et al.<br />
(1999) Trauma faculty and trauma team activation:<br />
impact on trauma system function and patient<br />
outcome. J Trauma 47:576-581<br />
26. Knudson Mm, Shagoury C, Lewis Fr (1992) Can adult<br />
trauma surgeons care for injured children? J Trauma<br />
32:729-739<br />
27. Krötz M, Bode Pj, Häuser H et al. (2002)<br />
Interdisziplinäre Schockraumversorgung: Personelle,<br />
apparative und räumlich-logistische Konzepte in 3<br />
Traumakrankenhäusern in Europa. Radiologe 42:522-<br />
532 [LoE 5]<br />
28. Lecky F, Woodford M, Yates Dw et al. (2000) Trends<br />
in trauma care in England and Wales 1989-97. Lancet<br />
355:1771-1775 [LoE 4]<br />
29. Lloyd Da, Patterson M, Robson J et al. (2001) A<br />
stratified response system for the emergency<br />
management of the severely injured. Ann R Coll Surg<br />
Engl 83:15-20<br />
30. Lomas Ga, Goodall O (1994) Trauma teams vs nontrauma<br />
teams. Accid Emerg Nurs 2:205-210 [LoE 2b]<br />
31. Lossius Hm, Langhelle A, Pillgram-Larsen J et al.<br />
(2000) Efficiency of activation of the trauma team in a<br />
Norwegian trauma referral centre. Eur J Surg<br />
166:760-764<br />
32. Lu Wh, Kolkman K, Seger M et al. (2000) An<br />
evaluation of trauma team response in a major trauma<br />
Emergency room – Personnel and equipment resources 142
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
hospital in 100 patients with predominantly minor<br />
injuries. Aust N Z J Surg 70:329-332<br />
33. Luchette F, Kelly B, Davis K et al. (1997) Impact of<br />
the in-house trauma surgeon on initial patient care,<br />
outcome, and cost. J Trauma 42:490-497 [LoE 2b]<br />
34. Mathiasen Ra, Eby Jb, Jarrahy R et al. (2001) A<br />
dedicated craniofacial trauma team improves<br />
efficiency and reduces cost. J Surg Res 97:138-143<br />
[LoE 2b]<br />
35. Mclauchlan Ca, Jones K, Guly Hr (1997)<br />
Interpretation of trauma radiographs by junior doctors<br />
in accident and emergency departments: a cause for<br />
concern? J Accid Emerg Med 14:295-298 [LoE 2b]<br />
36. Nakayama Dk, Copes Ws, Sacco W (1992)<br />
Differences in trauma care among pediatric and<br />
nonpediatric trauma centers. J Pediatr Surg 27:427-<br />
431<br />
37. Nerlich M, Maghsudi M (1996) <strong>Polytrauma</strong>-<br />
Management: Präklinische und<br />
Schockraumversorgung. Unfallchirurg 99:595-606<br />
38. Ochsner Mg, Schmidt Ja, Rozycki Gs et al. (1995)<br />
The evaluation of a two-tier trauma response system<br />
at a major trauma center: is it cost effective and safe?<br />
J Trauma 39:971-977<br />
39. Palmer Sh, Maheson M (1995) A radiological review<br />
of cervical spine injuries from an accident and<br />
emergency department: has the ATLS ® made a<br />
difference? J Accid Emerg Med 12:189-190 [LoE 2b]<br />
40. Plaisier Br, Meldon Sw, Super Dm et al. (1998)<br />
Effectiveness of a 2-specialty, 2-tiered triage and<br />
trauma team activation protocol. Ann Emerg Med<br />
32:436-441<br />
41. Podnos Yd, Wilson Se, Williams Ra (1998) Effect of<br />
surgical panel composition on patient outcome at a<br />
level I trauma center. Arch Surg 133:847-854 [LoE<br />
2b]<br />
42. Poon A, Mccluskey Pj, Hill Da (1999) Eye injuries in<br />
patients with major trauma. J Trauma 46:494-499<br />
[LoE 4]<br />
43. Porter Jm, Ursic C (2001) Trauma attending in the<br />
resuscitation room: does it affect outcome? Am Surg<br />
67:611-614<br />
44. Rhodes M, Smith S, Boorse D (1993) Pediatric trauma<br />
patients in an 'adult' trauma center. J Trauma 35:384-<br />
393<br />
45. Ruchholtz S, Waydhas C, Lewan U et al. (2002) A<br />
multidisciplinary quality management system for the<br />
early treatment of severely injured patients:<br />
implementation and results in two trauma centers.<br />
Intensive Care Med 28:1395-1404<br />
46. Ryan Jm, Gaudry Pl, Mcdougall Pa et al. (1998)<br />
Implementation of a two-tier trauma response. Injury<br />
29:677-683<br />
47. Sakellariou A, Mcdonald Pj, Lane Rh (1995) The<br />
trauma team concept and its implementation in a<br />
district general hospital. Ann R Coll Surg Engl 77:45-<br />
52<br />
48. Stauffer Ug (1995) Surgical and critical care<br />
management of children with life-threatening injuries:<br />
the Swiss experience. J Pediatr Surg 30:903-910<br />
49. Stoneham J, Riley B, Brooks A et al. (2001) Recent<br />
advances in trauma management. Trauma 3:143-150<br />
50. Sugrue M, Seger M, Kerridge R et al. (1995) A<br />
prospective study of the performance of the trauma<br />
team leader. J Trauma 38:79-82<br />
51. Tscherne H, Regel G, Sturm Ja et al. (1987)<br />
Schweregrad und Prioritäten bei<br />
Mehrfachverletzungen. Chirurg 58:631-640<br />
52. Velmahos Gc, Fili C, Vassiliu P et al. (2001) Aroundthe-clock<br />
attending radiology coverage is essential to<br />
avoid mistakes in the care of trauma patients. Am<br />
Surg 67:1175-1177 [LoE 2b]<br />
53. Vernon Dd, Furnival Ra, Hansen Kw et al. (1999)<br />
Effect of a pediatric trauma response team on<br />
emergency department treatment time and mortality of<br />
pediatric trauma victims. Pediatrics 103:20-24 [LoE<br />
2b]<br />
54. Wenneker Ww, Murray Dh, Jr., Ledwich T (1990)<br />
Improved trauma care in a rural hospital after<br />
establishing a level II trauma center. Am J Surg<br />
160:655-658<br />
55. Wissenschaftlicher Arbeitskreis Neuroanästhesie Der<br />
Deutschen Gesellschaft Für Anästhesiologie Und<br />
Intensivmedizin, Arbeitsgemeinschaft<br />
Intensivmedizin Und Neurotraumatologie Der<br />
Deutschen Gesellschaft Der Deutschen Gesellschaft<br />
Für Neurochirurgie, Sektion Rettungswesen Und<br />
Katastrophenmedizin Der Deutschen<br />
Interdisziplinären Vereinigung Für Intensiv- Und<br />
Notfallmedizin (2000) Empfehlungen zur<br />
Erstversorgung des Patienten mit Schädel-Hirn-<br />
Trauma bei Mehrfachverletzung. In: Opderbecke HW,<br />
Weißbauer W (eds) [LoE 5]<br />
56. Wong K, Petchell J (2003) Trauma teams in Australia:<br />
a national survey. ANZ J Surg 73:819-825<br />
57. Wurmb et al. Unfallchirurg 2009; 112: 390-399<br />
58. Wyatt Jp, Henry J, Beard D (1999) The association<br />
between seniority of accident and emergency doctor<br />
and outcome following trauma. Injury 30:165-168<br />
[LoE 2b]<br />
Emergency room – Personnel and equipment resources 143
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.3 Criteria for emergency room activation<br />
Efficiently working trauma score systems or parameters should select and identify patients so<br />
precisely that the necessary treatment is allotted to each casualty according to his injury severity.<br />
The difficulty lies in being able to assess injury severity adequately. Ideally, trauma/emergency<br />
room activation criteria should minimize as much as possible the rate of undertriage as well as<br />
that of overtriage of severely injured patients. Undertriage describes the proportion of patients<br />
who, despite a relevant severe injury requiring emergency room treatment, for example, are not<br />
identified as such. In contrast, overtriage describes the proportion of patients with a minor injury<br />
or none at all who nevertheless are classified as severely injured and, for example, are delivered<br />
to an emergency room. An advantage of overtriage - besides the optimum treatment of each<br />
patient - can be team training as the interplay and sequences can be practiced in “quasi-serious<br />
situations” even with non-severely injured persons. However, overtriage is associated with<br />
considerable costs and an often considerable disruption to routine sequences. The effectiveness<br />
of individual, different trauma score systems/trauma criteria can be described by parameters such<br />
as sensitivity, specificity, positive predictive value, and the calculation of overtriage and<br />
undertriage. The American College of Surgeons Committee on Trauma [25] gives an undertriage<br />
rate of 5-10% with simultaneous 30-50% overtriage as necessary in order to carry out efficient<br />
emergency room care. In a paper by Kane et al., the authors describe how, in order to attain a<br />
sensitivity of more than 80%, the rate of overtriage could not be brought below 70%.<br />
The primary goal of trauma/emergency room activation criteria is therefore to keep undertriage<br />
low and at the same time not increase overtriage to an unacceptable level.<br />
Emergency room – Criteria for emergency room activation<br />
144
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Activation criteria<br />
Key recommendation:<br />
The trauma/emergency room team should be activated for the following<br />
injuries:<br />
� Systolic blood pressure below 90 mmHg after trauma<br />
� Penetrating injuries to the neck and torso regions<br />
� Gunshot wounds to the neck and torso regions<br />
� GCS below 9 after trauma<br />
� Respiratory impairment/requirement for intubation after trauma<br />
� Fracture of more than 2 proximal bones<br />
� Unstable chest<br />
� Pelvic fractures<br />
� Amputation injury proximal to hands/feet<br />
� Spinal cord injury<br />
� Open head wounds<br />
� Burns > 20% and degree ≥2b<br />
Explanation:<br />
Blood pressure/respiratory rate<br />
Emergency room – Criteria for emergency room activation<br />
GoR A<br />
Individual studies have shown that hypotension following trauma with a systolic blood pressure<br />
below 90 mmHg is a good predictor/good criterion for activating the emergency room team.<br />
Thus, Franklin et al. [1] showed that 50% of trauma patients with prehospital hypotension or<br />
hypotension at admission were sent for immediate surgery or transferred to an intensive care<br />
unit. A total of 75% of patients with hypotension were operated on during the course of the<br />
hospital stay.<br />
Tinkoff et al. [2] found a 24-fold increased mortality, a 7-fold increased admission to the<br />
intensive care unit, and a 1.6-fold increased emergency surgery rate where hypotension was<br />
present after trauma as an expression of existing shock. In the recommendations of the American<br />
College of Surgeons Committee of Trauma [25], hypotension is found to be an important<br />
criterion for admission to a trauma center. Smith et al. [3] cite hypotension as a consistently used<br />
criterion for trauma team activation in all hospitals in the state of New South Wales in Australia.<br />
In a review by Henry et al. [4] of the New York State Trauma Registry, there were mortality<br />
145
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
rates of 32.9% in trauma patients with an SBP (systolic blood pressure) of < 90 mmHg and<br />
28.8% for trauma patients with a respiratory rate of < 10 or > 29/min.<br />
Gunshot wounds<br />
In a study by Sava et al. [5], the authors ascertained that gunshot wounds to the torso as a single<br />
activation criterion had a high informative value similar to the TTAC (Trauma Team Activation<br />
Criteria) used up till then. In a subgroup with gunshot wounds to the abdominal/pelvic region,<br />
the frequency of severe injuries was equal in the group with and without TTAC (74.1% and<br />
70.8%, p = 0.61). A proviso must be made here that the overwhelming proportion of patients<br />
(94.4%) with gunshot wounds had already been identified using the TTAC. Tinkoff et al. [2] also<br />
found a significant correlation between gunshot wounds to the neck or torso and the need to<br />
admit to an intensive care unit (see below). Furthermore, this criterion was predictive for the<br />
existence of severe or fatal injuries and for emergency surgery. In a retrospective analysis,<br />
Velmahos et al. [6] report an overall survival rate following penetrating gunshot and stab wounds<br />
of over 5.1% in patients without vital signs in the emergency room. In a literature review (25<br />
years, 24 studies), Rhee et al. [7] found a survival rate of 8.8% following emergency<br />
thoracotomy due to penetrating trauma.<br />
The American College of Surgeons Committee on Trauma [25] listed various, differentlyweighted<br />
triage criteria in its last edition (2006). The Step One and Step Two criteria, which<br />
necessitate admission to a Level 1 or Level 2 trauma center include: a) GCS below 15 or b)<br />
systolic blood pressure (BP) below 90 mmHg or c) respiratory rate below 10/min or above<br />
29/min (Step One). Step Two criteria are a) penetrating injuries to the head, neck, torso, and<br />
proximal long bones, b) unstable thorax, c) fracture of 2 or more proximal long bones, d)<br />
amputation(s) proximal to the hands/feet, e) unstable pelvic fractures, f) open head fractures, and<br />
g) spinal cord injuries. Overall, there is currently rather a lack of evidence for the cited criteria.<br />
In a study by Knopp [8] on 1,473 trauma patients, the authors found a positive predictive value<br />
(PPV) of 100% for an ISS > 15 for spinal cord injuries and amputation injuries; however,<br />
fractures of the long bones only had a PPV of 19.5%.<br />
In their study, Tinkoff et al. [2] examined several of these criteria for their accuracy in<br />
identifying severely injured and high-risk patients. Trauma patients who fulfilled the criteria of<br />
the ACS COT had more severe injuries, higher mortality, and longer stay in intensive care than<br />
patients in the control group. Systolic blood pressure below 90 mmHg, endotracheal intubation,<br />
and a gunshot wound to the neck/torso were predictive in the study for the necessity of<br />
emergency surgery or admission to intensive care. Mortality was markedly increased with<br />
systolic blood pressure below 90 mmHg, endotracheal intubation or GCS of less than 9. In their<br />
study, Kohn et al. [9] analyzed various trauma team activation criteria (see Table 1a), which are<br />
similar to those of the ACS COT. Kohn et al. found the parameter “respiratory rate below 10 or<br />
above 29/min” as the most predictive in terms of informative value for the presence of a severe<br />
injury. Additional parameters with high prediction were: a) burns with more than 20% body<br />
surface (BS), b) spinal cord injury, c) systolic blood pressure below 90 mmHg, d) tachycardia,<br />
and e) gunshot wounds to the head, neck or torso.<br />
Emergency room – Criteria for emergency room activation<br />
146
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Open head injuries<br />
With a lack of studies on the relevance of open head injuries, this criterion is regarded by the<br />
ACS COT rather as a significant indicator of severe injuries which require a high level of<br />
specialist medical competence and should thus be assigned to the Step One criteria.<br />
GCS<br />
Kohn et al. [9] regard a GCS of less than 10 as an important predictor of severe trauma. 44.2% of<br />
patients, for whom the ER team was activated because they had a low GCS, had confirmed<br />
severe injuries. The value of the GCS as a predictor of a severe injury and as an activation<br />
criterion for the emergency room team was also confirmed in studies by Tinkoff et al., Norwood<br />
et al., and Kühne et al. [2, 10, 11]. In these patients, Norwood as well as Kühne found that even<br />
GCS scores of less than 14 indicated pathologic intracerebral findings and the necessity for<br />
inpatient admission. However, according to this, the activation of the trauma/emergency room<br />
team does not appear to be absolutely necessary with these patients (GCS ≤ 14 and ≥ 11). For a<br />
GCS of less than 10, Engum [12] found a sensitivity of 70% for the endpoint OP, intensive care<br />
unit (ICU) or death. The odds ratio (OR) was 3.5 (95% CI: 1.6–7.5). The authors found a PPV of<br />
78% for the presence of a severe injury in children with a GCS < 12.<br />
Emergency room – Criteria for emergency room activation<br />
147
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
The trauma/emergency room team should be activated for the following<br />
additional criteria:<br />
� fall from more than 3 meters height<br />
� road traffic accident (RTA) with<br />
- frontal collision with intrusion by more than 50-75 cm<br />
- a change in speed of delta >30 km/h<br />
- collision involving a pedestrian or two-wheeler<br />
- death of a driver or pass<strong>eng</strong>er<br />
- ejection of a driver or pass<strong>eng</strong>er<br />
Explanation:<br />
Accident-related/-dependent criteria<br />
Emergency room – Criteria for emergency room activation<br />
GoR B<br />
Accident-related/-dependent criteria are evaluated very differently in the literature with regard to<br />
their informative value for the presence of severe trauma.<br />
Norcross et al., Bond et al., and Santaniello et al. [13, 14, 15] report on rates of overtriage of up<br />
to 92%, sensitivities of 70-50%, and PPV of 16.1% if accident-related mechanisms have been<br />
included as the sole criterion for describing the injury severity. If physiologic criteria were also<br />
used, a sensitivity of 80% was attained with a specificity of 90% [14].<br />
Knopp et al. found only poor positive predictive values for the parameters road traffic accident<br />
(RTA) with ejection or death of a driver or pass<strong>eng</strong>er and road traffic accident involving a<br />
pedestrian [8]. Engum et al. also found the lowest predictive power for the road traffic accident<br />
involving a pedestrian at 20 mph (miles per hour) and the road traffic accident with death of a<br />
driver or pass<strong>eng</strong>er and trauma from being run over [12]. In the ACS COT recommendations, the<br />
trauma from being run over was removed from the criteria in the current version. Frontal<br />
collision with intrusion by more than 20-30 inches, death of a driver or pass<strong>eng</strong>er, road traffic<br />
accident involving pedestrian/two-wheeler collision at ≥ 20 mph, and ejection of a driver or<br />
pass<strong>eng</strong>er are cited as Step Three criteria, i.e. there is no necessity to transport these patients to<br />
centers of the maximum care level. Kohn et al. [9] also regard the rollover trauma as lacking in<br />
suitability. According to Kohn et al., the same also applies to the criteria/parameters road traffic<br />
accident (RTA) with ejection or death of a driver or pass<strong>eng</strong>er and road traffic accident involving<br />
a pedestrian [9].<br />
Champion et al. [16] regard a vehicle rollover as an important indication of severe injury. The<br />
average probability of suffering a fatal injury is markedly greater after a rollover than not after<br />
one.<br />
148
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Nevertheless, the ACS COT removed the rollover mechanism from its triage criteria because<br />
relevant injuries after such an accident incident would already be included in Step One or Step<br />
Two.<br />
Deformation to vehicle bodywork<br />
In a multivariate analysis of 621 patients, Palanca et al. [17] found no significant relationship<br />
between vehicle deformation (intrusion of > 30 cm or > 11.8 inches) and the presence of a<br />
relevant severe injury (OR: 1.5; 95% CI: 1.0–2.3; p = 0.05). Henry came to comparable results in<br />
the multivariate analysis in his study [4]. Using the data of the National Automotive Sampling<br />
System Crashworthiness Data System (NASS CDS), Wang found a PPV of 20% for an ISS > 15<br />
[18].<br />
Death of a driver or pass<strong>eng</strong>er<br />
Knopp et al. found an increased risk of surgery or death if a driver or pass<strong>eng</strong>er was fatally<br />
injured (OR: 39.0; 95% CI: 2.7–569; PPV 21.4%) [8]. Palanca et al. [17] could not confirm any<br />
statistically significant relationship between the death of a driver or pass<strong>eng</strong>er and the existence<br />
of a severe injury even if the simultaneous frequency of a severe injury was 7%.<br />
Fall from a great height<br />
In a prospective study by Kohn et al. [9], 9.4% of patients who had suffered a fall from more<br />
than 6 meters height had severe injuries - defined as intensive care admission or immediate<br />
surgery. Yagmur et al. [19] found 9 meters to be the average height for patients who died from<br />
the consequences of a fall.<br />
Burns<br />
It is essential to distinguish whether a thermal injury is present without additional injuries. In the<br />
case of a combination injury where the non-thermal component is predominant, the patient<br />
should be brought to a trauma center [25].<br />
Age<br />
Kohn et al. [9] analyzed various trauma team activation criteria which are similar to those of the<br />
ACS COT. Of the criteria examined, “age over 65” had the least informative value. The authors<br />
therefore recommended that this criterion be removed from the “first-tier activations”.<br />
Demetriades et al. [20] found a markedly higher mortality (16%), increased admission to<br />
intensive care, and an increased necessity for surgical intervention (19%) in patients over 70<br />
years of age compared to younger patients. However, all patients who could remain outpatients<br />
were excluded from the study beforehand so that the cited percentages are probably an<br />
overestimation. Kühne et al. [21] found an increase in mortality - irrespective of ISS - with<br />
increasing age in a retrospective study of over 5,000 trauma patients in the <strong>DGU</strong> Trauma<br />
Registry. The cut-off value of mortality increase was 56 years. MacKenzie et al. [22] also found<br />
a marked increase in (fatal) injuries from > 55 years of age upwards. In a 13-year review,<br />
Grossmann et al. [23] found that mortality increased by 6.8% per additional year over 65 years<br />
Emergency room – Criteria for emergency room activation<br />
149
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
of age. In a study by Morris et al. [24], patients who died from the consequences of an accident<br />
had a lower ISS than younger patients in the control group.<br />
Overall, there is variation and controversy over the assessment of the influence of age on the<br />
outcome of trauma. The American College of Surgeons COT has classified age as a criterion for<br />
triage in a Level 1 or Level 2 trauma center as rather low (Step Four criterion).<br />
Emergency room – Criteria for emergency room activation<br />
150
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1 Franklin GA, Boaz PW, Spain DA, Lukan JK, Carrillo<br />
EH, Richardson JD. Prehospital hypotension as a<br />
valid indicator of trauma team activation. J Trauma.<br />
2000; 48: 1034-7; discussion 1037-9.<br />
2 Tinkoff GH,O'Connor RE. Validation of new trauma<br />
triage rules for trauma attending response to the<br />
emergency department. J Trauma. 2002; 52: 1153-8;<br />
discussion 1158-9.<br />
3 Smith J, Caldwell E, Sugrue M. Difference in trauma<br />
team activation criteria between hospitals within the<br />
same region. Emerg Med Australas. 2005; 17: 480-7.<br />
4 Henry MC. Trauma triage: New York experience.<br />
Prehosp Emerg Care. 2006; 10: 295-302.<br />
5 Sava J, Alo K, Velmahos GC, Demetriades D. All<br />
patients with truncal gunshot wounds deserve trauma<br />
team activation. J Trauma. 2002; 52: 276-9.<br />
6 Velmahos GC, Degiannis E, Souter I, Allwood AC,<br />
Saadia R. Outcome of a strict policy on emergency<br />
department thoracotomies. Arch Surg. 1995; 130:<br />
774-7.<br />
7 Rhee PM, Acosta J, Bridgeman A, Wang D, Jordan<br />
M, Rich N. Survival after emergency department<br />
thoracotomy: review of published data from the past<br />
25 years. J Am Coll Surg. 2000; 190: 288-98.<br />
8 Knopp R, Yanagi A, Kallsen G, Geide A, Doehring L.<br />
Mechanism of injury and anatomic injury as criteria<br />
for prehospital trauma triage. Ann Emerg Med. 1988;<br />
17: 895-902.<br />
9 Kohn MA, Hammel JM, Bretz SW, Stangby A.<br />
Trauma team activation criteria as predictors of<br />
patient disposition from the emergency department.<br />
Acad Emerg Med. 2004; 11: 1-9.<br />
10 Kuhne CA, Homann M, Ose C, Waydhas C, Nast-<br />
Kolb D, Ruchholtz S. [Emergency room patients].<br />
Unfallchirurg. 2003; 106: 380-6.<br />
11 Norwood SH, McAuley CE, Berne JD, Vallina VL,<br />
Creath RG, McLarty J. A prehospital glasgow coma<br />
scale score < or = 14 accurately predicts the need for<br />
full trauma team activation and patient hospitalization<br />
after motor vehicle collisions. J Trauma. 2002; 53:<br />
503-7.<br />
12 Engum SA, Mitchell MK, Scherer LR, Gomez G,<br />
Jacobson L, Solotkin K, Grosfeld JL. Prehospital<br />
triage in the injured pediatric patient. J Pediatr Surg.<br />
2000; 35: 82-7.<br />
13 Norcross ED, Ford DW, Cooper ME, Zone-Smith L,<br />
Byrne TK, Yarbrough DR, 3rd. Application of<br />
American College of Surgeons' field triage guidelines<br />
by pre-hospital personnel. J Am Coll Surg. 1995; 181:<br />
539-44 [Evidenzbasierte Leitlinie]<br />
Emergency room – Criteria for emergency room activation<br />
14 Bond RJ, Kortbeek JB, Preshaw RM. Field trauma<br />
triage: combining mechanism of injury with the<br />
prehospital index for an improved trauma triage tool. J<br />
Trauma. 1997; 43: 283-7.<br />
15 Santaniello JM, Esposito TJ, Luchette FA, Atkian<br />
DK, Davis KA, Gamelli RL. Mechanism of injury<br />
does not predict acuity or level of service need: field<br />
triage criteria revisited. Surgery. 2003; 134: 698-703;<br />
discussion 703-4.<br />
16 Champion HR, Lombardo LV, Shair EK. The<br />
importance of vehicle rollover as a field triage<br />
criterion. J Trauma. 2009; 67: 350-7.<br />
17 Palanca S, Taylor DM, Bailey M, Cameron PA.<br />
Mechanisms of motor vehicle accidents that predict<br />
major injury. Emerg Med (Fremantle). 2003; 15: 423-<br />
8.<br />
18 Wang SW, Review of NASS CDS and CIREN data<br />
for mechanism criteria for field triage. Presented at<br />
the National Expert Panel on Field Triage meeting.<br />
2005: Atlanta, Georgia.<br />
19 Yagmur Y, Guloglu C, Aldemir M, Orak M. Falls<br />
from flat-roofed houses: a surgical experience of 1643<br />
patients. Injury. 2004; 35: 425-8.<br />
20 Demetriades D, Sava J, Alo K, Newton E, Velmahos<br />
GC, Murray JA, Belzberg H, Asensio JA, Berne TV.<br />
Old age as a criterion for trauma team activation. J<br />
Trauma. 2001; 51: 754-6; discussion 756-7.<br />
21 Kuhne CA, Ruchholtz S, Kaiser GM, Nast-Kolb D.<br />
Mortality in severely injured elderly trauma patients-when<br />
does age become a risk factor? World J Surg.<br />
2005; 29: 1476-82.<br />
22 MacKenzie EJ, Rivara FP, Jurkovich GJ, Nathens AB,<br />
Frey KP, Egleston BL, Salkever DS, Scharfstein DO.<br />
A national evaluation of the effect of trauma-center<br />
care on mortality. N Engl J Med. 2006; 354: 366-78.<br />
23 Grossman MD, Miller D, Scaff DW, Arcona S. When<br />
is an elder old? Effect of preexisting conditions on<br />
mortality in geriatric trauma. J Trauma. 2002; 52:<br />
242-6.<br />
24 Morris JA, Jr., MacKenzie EJ, Edelstein SL. The<br />
effect of preexisting conditions on mortality in trauma<br />
patients. JAMA. 1990; 263: 1942-6.<br />
25 American College of Surgeons Committee on Trauma<br />
(2006) Resources for optimal care of the injured<br />
patient. American College of Surgeons, Chicago<br />
151
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.4 Thorax<br />
What importance does the previous medical history have?<br />
Key recommendations:<br />
A detailed previous medical history (from third party if necessary) should be<br />
taken.<br />
High energy trauma and road traffic accidents with lateral collision should be<br />
interpreted as indications of a chest injury/aortic rupture.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
Even if there are only a few studies on taking the medical history with regard to chest injury, it is<br />
still an essential requirement for assessing the injury severity and the injury pattern and is used to<br />
establish whether an accident has in fact occurred. Collecting exact details of the circumstances<br />
of the accident is important in taking the medical history. The speed of the vehicle at the moment<br />
of impact and the direction of the impacting force are particularly important questions in road<br />
traffic accidents involving pass<strong>eng</strong>er vehicles. For instance, there are marked differences in the<br />
occurrence and severity of the chest injury and the overall injury severity depending on whether<br />
the impact is lateral or frontal.<br />
Horton et al. [1] demonstrated a sensitivity of 100% and a specificity of 34% for aortic rupture in<br />
a lateral collision of the vehicle and/or with a change in velocity (delta V) ≥ 30 km/h. In another<br />
study [2], high velocity injuries at speeds of > 100 km/h were graded as suspicious for aortic<br />
rupture. Richter et al [3] also found an increased risk of chest injury in lateral collisions. In this<br />
study, delta V correlated with the AIS (thorax), ISS, and clinical course. In the study by<br />
Ruchholtz et al. [4], chest injury was diagnosed in 8 out of 10 cases of pass<strong>eng</strong>er vehicle<br />
accidents involving lateral collision. In this study, 72% of patients who had an accidental fall<br />
also sustained a chest injury.<br />
In a study of 286 pass<strong>eng</strong>er vehicle occupants with an ISS ≥ 16, the probability of an aortic<br />
injury after a lateral collision was twice as high as after a frontal collision [5]. An impact in the<br />
region of the superior thoracic aperture appears to be particularly important and there appears to<br />
be increased incidence of fractures to ribs 1-4 [6].<br />
Children also have a 5-fold higher risk of a severe chest injury (AIS ≥ 3) and a significantly<br />
higher overall injury severity when they are pass<strong>eng</strong>er vehicle occupants in a lateral collision<br />
compared to a frontal collision [7].<br />
The effect of a seatbelt on the presence of a chest injury appears uncertain. Thus, in a<br />
retrospective study of 1,124 patients with relatively minor overall injury severity (ISS 11.6),<br />
Porter and Zaho [8] did find cumulative incidence of sternum fractures (4% versus 0.7%) in<br />
Emergency room – Abdomen 152
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
belted patients but the proportion of patients with chest injury was identical in both groups<br />
(21.8% versus 19.1%).<br />
What importance do physical examination findings have?<br />
Key recommendations:<br />
A clinical examination of the thorax must be carried out. GoR A<br />
The physical examination should include auscultation. GoR B<br />
Explanation:<br />
Even if there are hardly any scientific studies except for auscultation on the importance and the<br />
required scope of the physical examination, it is still an indispensable requirement in identifying<br />
symptoms and in making (suspected) diagnoses. The above-mentioned examinations are used to<br />
identify relevant, life-threatening or potentially fatal disorders or injuries which require<br />
immediate, specific treatment. Even if a physical examination has already been carried out in the<br />
prehospital phase and a chest drain has already been inserted, the physical examination must be<br />
carried out in the emergency room as a change could have occurred in the constellation of<br />
findings.<br />
The initial physical examination should include:<br />
� auscultation (presence of breath sounds and lateral uniformity)<br />
� details of pain<br />
� respiratory rate<br />
� inspection (skin and soft tissue injuries, symmetry of the thorax, symmetry of respiratory<br />
excursion, paradoxical respiration, inflow congestion, belt marks)<br />
� palpation (subcutaneous emphysema, crepitation, tenderness points)<br />
� dyspnea<br />
Monitoring ventilation pressure, blood oxygen saturation (pulse oxymetry), and expiratory<br />
CO2concentration can be added during the course.<br />
The auscultation finding is the lead finding for making a diagnosis of chest injury. In addition,<br />
subcutaneous emphysema, palpable instabilities, crepitations, pain, dyspnea, and elevated<br />
ventilation pressures can be indications of a chest injury.<br />
In a prospective study, Bokhari et al. [9] examined 676 patients with blunt or penetrating chest<br />
injury for clinical signs and symptoms of hemopneumothorax. But out of 523 patients with blunt<br />
trauma, only 7 had a hemopneumothorax. In this group, auscultation has a sensitivity and<br />
Emergency room – Abdomen 153
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
negative predictive value of 100%. The specificity was 99.8% and positive predictive value was<br />
87.5%. In penetration injuries, the sensitivity of auscultation is 50%, specificity and positive<br />
predictive value 100%, and negative predictive value 91.4%. In both mechanisms of injury, pain<br />
and tachypnea are inadequate indications of the presence of a hemopneumothorax.<br />
In a retrospective study of 118 patients with penetrating trauma, Chen et al. [10] also found for<br />
auscultation only a sensitivity of 58%, specificity and positive predictive value of 98%, and<br />
negative predictive value of 61%. In a prospective study of 51 patients with penetrating trauma,<br />
the combination of percussion and auscultation exhibited a sensitivity of 96%, specificity of<br />
93%, and positive predictive value of 83% [11].<br />
These studies show that in penetrating trauma a weakened breath sound generally has an<br />
underlying pneumothorax and a chest drain can then be inserted before a radiograph is taken.<br />
In their search for a clinical decision aid to identify children with chest injury, Holmes et al. [12]<br />
studied 986 patients, 80 of whom had a chest injury. This yielded an odds ratio of 8.6 for a<br />
positive auscultation finding, an odds ratio of 3.6 for an abnormal physical examination<br />
(reddening, skin lesions, crepitation, tenderness), and an odds ratio of 2.9 for an elevated<br />
respiratory rate.<br />
What importance is attached to the diagnostic equipment (chest radiograph, ultrasound,<br />
CT, angiography, ECG, laboratory tests) and when is it indicated?<br />
Key recommendations:<br />
If a chest injury cannot be clinically excluded, a radiologic diagnostic study<br />
must be carried out in the emergency room.<br />
Every patient with clinical and anamnestic indications of a severe chest injury<br />
should undergo a helical CT scan of the thorax with contrast agent.<br />
Explanation:<br />
GoR A<br />
GoR B<br />
As given under points 1 and 2, both the mechanism of injury and the findings from the physical<br />
examination provide important information on the presence or absence of a chest injury. For this<br />
reason, a chest radiograph can be dispensed with if, with respect to the circumstances of the<br />
accident, a chest injury can be excluded and at the same time there are no findings from the<br />
physical examination that make an intrathoracic injury probable.<br />
On the other hand, a chest radiograph should be taken of all patients with confirmed chest injury.<br />
This serves to confirm diagnoses already made and to confirm or exclude further possible<br />
diagnoses. The initially taken radiograph is used to diagnose a pneumothorax and/or<br />
hemothorax, rib fractures, tracheobronchial injuries, pneumomediastinum, mediastinal<br />
hematoma, and pulmonary contusion [13]. The chest radiograph is widely used as the primary<br />
diagnostic tool due to its low costs and availability. Nevertheless, there is little evidence on<br />
Emergency room – Abdomen 154
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
sensitivity and specificity in the diagnosis of pulmonary or thoracic injuries. There are only a<br />
few studies that report on a series of major injuries missed in the radiographs.<br />
In a prospective study of 100 patients, there was evidence that the most important chest injuries<br />
can be detected by a chest radiograph examination. The sensitivity of images taken upright was<br />
78.7% and that of supine images 58.3% [14]. On the other hand, McLellan et al. [15] found<br />
autopsy evidence in a series of 37 patients who died within 24 hours of admission that the chest<br />
radiograph did not detect important injuries in 11 cases. Among these were 11 cases of multiple<br />
rib fractures, 3 sternum fractures, 2 diaphragmatic ruptures, and 1 aortic intimal tear.<br />
The chest radiograph offers sufficient accuracy for indicating a chest drain, for example. In a<br />
prospective study of 400 multiply injured patients, Peytel et al. [16] thus showed that insertion of<br />
chest drains (n = 77) based on the radiographic findings was correct in all cases.<br />
Yet, numerous studies have shown that intrathoracic injuries can be revealed with significantly<br />
higher frequency by CT scan than by chest radiograph alone. In particular, there is a marked<br />
superiority in the detection of pneumothoraces and hemothoraces, pulmonary contusion, and<br />
aortic injuries. Here, preference should be given to the helical CT with administration of<br />
intravenous (i.v.) contrast agent [17]. By using multi-slice helical CTs, the examination time for<br />
a full-body scan can be reduced from an average of 28 to 16 minutes compared to the single-slice<br />
helical CT, and initial diagnostic information can even be taken from the realtime images on the<br />
monitor [18].<br />
In a series of 103 severely injured patients, Trupka et al. [19] obtained additional information<br />
from 65% of patients on the underlying chest injury (pulmonary contusion n = 33, pneumothorax<br />
n = 34, hemothorax n = 21) compared to the radiographic examination. In 63% of these patients,<br />
direct therapeutic consequences resulted from the additional information, which in the majority<br />
of cases consisted of the chest drain being re-inserted or corrected.<br />
In patients with relevant trauma (road traffic accidents with crash speed > 15 km/h, fall from a<br />
height of > 1.5 m), Exadaktylos et al. [20] were unable to detect chest injuries in 25 out of 93<br />
patients using the conventional radiograph. In 13 of these 25 patients, however, the CT showed<br />
in part substantial chest injuries, including 2 aortic lacerations. In a prospective study of 112<br />
patients with deceleration trauma, Demetriades et al. [21] performed a helical CT scan of the<br />
chest, which produced the diagnosis of aortic rupture in 9 patients. Four of these patients<br />
exhibited a normal chest radiograph. The aortic rupture was confirmed by CT in 8 patients. In<br />
one patient with an injury to the brachiocephalic artery, the CT revealed a local hematoma but<br />
the vessel was not visible in the CT slices. Even in patients without clinical signs of chest injury<br />
and with a negative radiographic finding, chest injuries showed up in the CT in 39% of patients,<br />
and in 5% of cases led to a change in treatment [22].<br />
Blostein et al. [23] come to the conclusion that a routine CT is not to be recommended generally<br />
in blunt chest injury as, out of 40 prospectively studied patients with defined chest injuries, 6<br />
patients had a change in treatment (5x chest drains, 1x aortography with negative result).<br />
However, the authors also state that, in patients who require intubation and ventilation, the CT<br />
produces findings that are not visible on the conventional radiograph. In patients with an<br />
oxygenation index (PaO2/FiO2) < 300, the CT can help to estimate the extent of the pulmonary<br />
Emergency room – Abdomen 155
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
contusion and to identify patients at risk of pulmonary failure. Moreover, patients can be<br />
identified in whom an incompletely decompressed hemo- and/or pneumothorax could lead to<br />
further decompensation. In a retrospective study with 45 children [24] with 1) pathologic<br />
radiographic finding (n = 27), 2) abnormal physical examination finding (n = 8), and 3)<br />
substantial impact on the chest wall (n = 33), additional injuries were found in the CT in 40%, of<br />
which 18% of cases led to a change in treatment.<br />
Although for blunt chest trauma the supplementary diagnostic information from the chest CT is<br />
generally accepted in more recent literature [25], there is controversy surrounding the benefit of<br />
the effect on the clinical outcome and it is not yet confirmed. In a prospective study by Guerrero-<br />
Lopez et al. [26], the chest CT proved to be more sensitive in detecting hemo/pneumothorax,<br />
pulmonary contusion, spinal fractures, and chest drain misplacements and led to treatment<br />
changes in 29% of cases. In the multivariate analysis, no therapeutic relationship could be<br />
ascertained between the CT and ventilation time, intensive care stay or mortality. The authors<br />
therefore conclude that a chest CT should only be performed if there are suspected severe<br />
injuries that can be confirmed or excluded by the CT.<br />
Current studies showed a clear benefit from multi-slice CTs of the chest if there was a defined<br />
indication. Brink et al. [122] studied its routine, selective use in 464 and 164 patients. The<br />
indications for a routine CT were: high-energy trauma, vital parameters under threat, and severe<br />
injuries such as pelvic or spinal fractures, for example. The indications for a selective CT were:<br />
abnormal mediastinum, more than 3 rib fractures, pulmonary shadowing, emphysema, and<br />
fractures in the thoracolumbar spine. Injuries which were not visible in the conventional<br />
radiograph were found in 43% of patients who underwent routine CT. This led to changes in<br />
treatment for 17% of patients. Among the 7.9% of patients with a normal chest radiograph,<br />
Salim et al. [121] found pneumothoraces in 3.3%, a suspected aortic rupture in 0.2%, pulmonary<br />
contusions in 3.3%, and rib fractures in 3.7%.<br />
If the literature results are summarized, this produces an indication for chest CT in the presence<br />
of the following indication criteria:<br />
Indication criteria for chest CT (summarized according to [121, 122]):<br />
� road traffic accident Vmax > 50 km/h<br />
� fall from > 3 m height<br />
� patient ejected from vehicle<br />
� rollover trauma<br />
� substantial vehicle deformation<br />
� pedestrian knocked down at > 10 km/h<br />
� biker knocked down at > 30 km/h<br />
� crush<br />
Emergency room – Abdomen 156
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
� pedestrian hit by vehicle and flung > 3 m<br />
� GCS < 12<br />
� Cardio-circulatory abnormalities (respiratory rate > 30/min, pulse > 120/min, systolic blood<br />
pressure < 100 mmHg, blood loss > 500 ml; capillary refill > 4 seconds)<br />
� Severe concomitant injuries (pelvic ring fracture, unstable spinal fracture or spinal cord<br />
compression)<br />
A retrospective multicenter analysis using the database of the <strong>DGU</strong> Trauma Registry found<br />
evidence of an improvement in survival probability for patients who had initially undergone a<br />
full-body CT scan [128]. The use of full-body CT leads to a relative reduction in mortality of<br />
25% in TRISS and of 13% in the RISC score. The CT proved to be an independent predictor for<br />
survival in the multivariate analysis.<br />
Emergency room – Abdomen 157
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
Every patient with clinical signs of chest injury should undergo an initial<br />
ultrasound examination (as part of the ultrasound examination of the torso)<br />
unless an initial chest helical CT with contrast agent has been carried out.<br />
Explanation:<br />
GoR B<br />
In a prospective study of 27 patients, chest X-rays, ultrasound examinations and CT were<br />
compared for accuracy in diagnosing a pneumothorax. The ultrasound examination of the thorax<br />
showed a sensitivity and a negative predictive value of 100% and a specificity of 94% [27]. In<br />
another study, the ultrasound examination compared with the X-ray examination showed a<br />
sensitivity and a positive predictive value of 95% and a negative predictive value of 100% for<br />
diagnosing a pneumothorax [28]. However, emphysema bullae, pleural adhesions or extensive<br />
subcutaneous emphysema can falsify the results of ultrasonography.<br />
As a retrospective study of 240 patients showed, the ultrasound examination ranks equally with<br />
the X-ray in diagnosing hemothorax. In 26 of these patients, the hemothorax was confirmed<br />
either by a chest drain or by chest CT. Ultrasound and chest X-ray each showed a sensitivity of<br />
96%, a specificity and a negative predictive value of 100%, and a positive predictive value of<br />
99.5% [29].<br />
In a prospective study of 261 patients with penetrating injuries, chest ultrasound had a sensitivity<br />
of 100% and specificity of 96.9% for detecting pericardial tamponade [30]. However, falsenegative<br />
ultrasound results can occur especially in patients with larger hemothoraces which can<br />
conceal smaller hematomas in the pericardium [31]. For this reason, sensitivity of the ultrasound<br />
was only 56% in this study.<br />
In a retrospective study of 37 patients with a pulmonary contusion confirmed in a CT,<br />
ultrasonography revealed a sensitivity of 94.6%, specificity of 96.1%, and a positive and<br />
negative predictive value of 94.6% and 96.1%, respectively [127].<br />
A chest helical CT scan with contrast agent excluded aortic injuries in patients without detected<br />
mediastinal hematoma, resulting in angiography not being necessary. Due to inadequate<br />
sensitivity, conventional CT examinations are less suited for the exclusion of an aortic injury<br />
[32, 33, 34].<br />
In the prospective study by Gavant et al. [35], 1,518 patients with blunt trauma underwent helical<br />
CT scans with contrast agent. Of this group, 127 patients with abnormalities in the mediastinum<br />
or aorta received aortography. An aortic injury was detected in 21 of these patients. Sensitivity<br />
for the CT and the aortography was 100 and 94.4%, respectively, whereas specificity was 81.7<br />
and 96.3%, respectively. It was concluded from this that in the absence of a mediastinal<br />
hematoma or if the aorta presented normally despite mediastinal hematoma, CT was sufficient<br />
for diagnosis and aortography was not necessary.<br />
Emergency room – Abdomen 158
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
In a prospective study, Dyer et al. [2] studied 1,346 patients after blunt chest trauma using<br />
contrast CT and 19 of the patients exhibited an aortic injury in the CT. All patients with positive<br />
CT findings had additional angiography. On the assumption of a periaortal hematoma as<br />
indication of an aortic injury, the CT has a sensitivity and a negative predictive value of 100%, a<br />
specificity of 95%, and a positive predictive value of 22%. The authors conclude that<br />
aortography should only be carried out in patients who have undergone a CT scan that cannot be<br />
interpreted or have a periaortal hematoma without direct signs of an aortic injury. Aortography<br />
can also prove necessary if the proximal extent of the aortic injury cannot be reliably assessed<br />
from the CT scan.<br />
In another prospective study of 494 patients with blunt chest trauma and mediastinal hematoma,<br />
the sensitivity for helical CT with contrast agent was 100% compared to 92% for aortography<br />
[36]. The specificity for the CT was 83% compared to 99% for aortography. The positive<br />
predictive value for the CT was 50% compared to 97% for aortography and the negative<br />
predictive value was 100% compared to 97%. In contrast to the above-mentioned study by Dyer<br />
et al. [2], Fabian et al. [36] conclude that patients with a mediastinal hematoma but no direct<br />
indication of an aortic injury also require no further diagnostic workup.<br />
The prospective study by Parker et al. [37] of 142 patients with radiographically abnormal<br />
mediastinum showed that both the helical CT and the aortography produced a sensitivity and a<br />
negative predictive value of 100% for aortic injury. In a retrospective study of 74 patients, Tello<br />
et al. [38] found normal CT findings in 39 patients. Of these 39 patients, 5 received an<br />
angiography which showed all findings normal and 34 patients were asymptomatic at a clinical<br />
follow-up examination 12 months later.<br />
There is general consensus now that helical CT with contrast agent is suitable for the exclusion<br />
of an aortic rupture [123, 124, 126]. There is a high probability that patients without detectable<br />
mediastinal hematoma have no aortic injury. Through the use of computed tomography, a large<br />
number of unnecessary aortographs can thus be avoided. However, if a brain CT scan is<br />
required, it should be carried out before the chest CT scan as the administration of contrast agent<br />
hampers the traumatic brain injury diagnosis.<br />
As comparative studies on angiography have shown, a CT without evidence of a mediastinal<br />
hematoma has a negative predictive value of 100% for the injury of large intrathoracic vessels<br />
[39]. However, the specificity in the study by Parker et al. [37] is only 89% due to 14 falsepositive<br />
findings. It is therefore recommended that angiography is performed on patients with a<br />
para-aortic hematoma detected by CT or with peribranch vessel hematomas and abnormal aortic<br />
contours. A negative contrast agent CT scan definitively excludes an aortic rupture [34, 40, 41].<br />
In an analysis of 54 patients with surgically detected aortic ruptures, Downing et al. [42] showed<br />
a sensitivity of 100% and specificity of 96% for helical CT. In a prospective study of 1,104<br />
patients with blunt chest trauma, Mirvis et al. [43] found mediastinal bleeding in 118 cases, of<br />
which 25 patients had an aortic rupture. For the aortic rupture, the helical CT showed a<br />
sensitivity and a negative predictive value of 100%, a specificity of 99.7%, and a positive<br />
predictive value of 89%. In a retrospective study on chest CT, Bruckner et al. found a negative<br />
Emergency room – Abdomen 159
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
predictive value of 99%, a positive predictive value of 15%, a sensitivity of 95%, and a<br />
specificity of 40%.<br />
In another prospective study of 1,009 patients, 10 patients had an aortic injury [44]. For the<br />
detection of direct signs of an aortic injury, the helical CT showed a sensitivity and a negative<br />
predictive value of 100%, a specificity of 96%, and a positive predictive value of 40%.<br />
In contrast to the above-mentioned prospective studies, Collier et al. [45] found only a sensitivity<br />
of 90% and a negative predictive value of 99% in a retrospective study of 242 patients; an aortic<br />
injury was found during the autopsy of one patient with a normal CT finding who had<br />
subsequently died from the consequences of a traumatic brain injury. In another retrospective<br />
study, angiography did not detect any aortic injury in 72 patients with an intrathoracic hematoma<br />
detected in a CT scan but no evidence of a direct aortic or other intrathoracic vessel injury [125].<br />
Transesophageal echocardiography (TEE) is a sensitive screening test [46, 47, 48] but<br />
angiography was often additionally carried out afterwards [49, 50]. TEE requires an experienced<br />
examiner [51] and is generally not so rapidly available as CT or angiography. The benefit of<br />
TEE may lie in imaging small intimal tears [47] which might not be visible in angiography or<br />
helical CT. However, TEE cannot provide good images of the ascending aorta and the branches<br />
of the aorta, which thereby elude diagnosis [52]. To date, there is only one prospective study in<br />
which helical CT has been compared to TEE in the diagnosis of aortic injury. CT and TEE<br />
showed a sensitivity of 73 and 93%, respectively, and a negative predictive value of 95%.<br />
Emergency room – Abdomen 160
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendations:<br />
A 3-lead ECG must be carried out to monitor vital functions. GoR A<br />
A 12-lead ECG should be carried out if there is a suspected blunt myocardial<br />
injury.<br />
Explanation:<br />
GoR B<br />
The initial ECG is essential for every severely injured patient. The ECG is necessary particularly<br />
in the absence of palpable pulses in order to differentiate in cardiac arrest between rhythms that<br />
can be defibrillated and those that cannot be defibrillated. The ECG can also be used as a<br />
screening test for potential cardiac complications from a blunt cardiac injury.<br />
Patients with a normal ECG, normal hemodynamics and no other additional relevant injuries do<br />
not require any further diagnostic tests or treatment. Cardiac enzymes are irrelevant in predicting<br />
complications from a blunt cardiac injury although raised troponin I levels can predict<br />
abnormalities in echocardiography. The echocardiogram should not be used in the emergency<br />
room for the diagnosis of blunt cardiac injury as it does not correlate with the occurrence of<br />
clinical complications. Echocardiography should be carried out on hemodynamically unstable<br />
patients in order to diagnose pericardial tamponade or pericardial rupture. Transthoracic<br />
echocardiography should be the method of choice here as to date there have been no clear<br />
evidence that transesophageal echocardiography is superior in diagnosing blunt cardiac injury.<br />
The ECG is a rapid, cost-effective, non-invasive examination which is always available in the<br />
emergency room. In a meta-analysis of 41 studies, it was shown that the ECG and the creatine<br />
kinase MB (CK-MB) levels have a higher importance than radionuclide examinations and the<br />
echocardiogram in diagnosing clinically relevant blunt cardiac injury (defined as a complication<br />
requiring treatment) [53].<br />
Fides et al. [54] report prospectively on 74 hemodynamically stable patients with normal initial<br />
ECG with no existing heart disease or other injuries. None of these patients developed cardiac<br />
complications. Another retrospective study of 184 children with blunt cardiac injury showed that<br />
patients with a normal ECG in the emergency room did not develop complications [55]. In a<br />
meta-analysis of 41 studies, an abnormal admission ECG correlated with the development of<br />
complications requiring treatment [53]. In contrast, in a prospective study by Biffl et al. [56], 17<br />
out of 107 patients with a contusion developed complications. Only 2 out of 17 patients initially<br />
had an abnormal ECG and 3 had sinus tachycardia. In another retrospective study of 133 patients<br />
in 2 establishments with clinical suspicion of a blunt cardiac injury, 13 patients (9.7%)<br />
developed complications but no patient with a normal initial ECG showed other abnormalities<br />
[57]. In the study by Miller et al. [58], 4 out of 172 patients developed arrhythmias requiring<br />
treatment with all 4 patients having an abnormal initial ECG. Wisner et al. [59] studied 95<br />
patients with suspected blunt cardiac injury and discovered that 4 patients developed clinically<br />
significant arrhythmias, only 1 of which had a normal admission ECG. In summary, the majority<br />
Emergency room – Abdomen 161
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
of authors recommend that asymptomatic, patients with stable circulation with a normal ECG do<br />
not require any further diagnostic tests or treatment.<br />
Key recommendation:<br />
The measurement of troponin I levels can be undertaken as an additional<br />
laboratory test in the diagnosis of blunt myocardial injuries.<br />
Explanation:<br />
GoR 0<br />
The studies on creatine kinase MB (CK-MB) in the diagnosis of blunt cardiac injury reveal a<br />
major limitation in the lack of a clear definition of blunt cardiac injury and the lack of a gold<br />
standard. In a retrospective study of 359 patients, 217 of whom were included to exclude blunt<br />
cardiac injury, 107 were diagnosed either because of an abnormal ECG finding or elevated CK-<br />
MB level. 16% of patients developed complications requiring treatment (arrhythmias or<br />
cardiogenic shock). All of these patients had an abnormal ECG but only 41% of them had<br />
elevated CK-MB levels. The course was without complication in patients with normal ECG and<br />
elevated CK-MB [56]. In a prospective study of 92 patients who all received an ECG, a CK-MB<br />
analysis, and continuous monitoring, 23 patients developed arrhythmias which, however, did not<br />
require any specific treatment. This shows that the number of arrhythmias requiring clinical<br />
treatment is small. 52% of patients with arrhythmias revealed elevated CK-MB levels whereas<br />
19% of patients without arrhythmias also had elevated CK-MK levels [60]. In addition, other<br />
studies showed no correlation between elevated CK-MB levels and cardiac complications [58,<br />
59, 61-65].<br />
Troponin I and T are sensitive markers in the diagnosis of myocardial infarction and<br />
considerably more specific than CK-MB as they are not present in skeletal muscle. In a study of<br />
44 patients, the 6 patients with blunt cardiac injury confirmed by echocardiography showed<br />
simultaneously elevated CK-MB and troponin I. Of the 37 patients without cardiac injury, 26<br />
had elevated CK-MB levels but no patient had elevated troponin I [66]. In another study of 28<br />
patients, 5 of whom had a blunt cardiac injury detected by echocardiography, troponin I had a<br />
specificity and sensitivity of 100% for the contusion. In a study of 29 patients, troponin T<br />
showed higher sensitivity (31%) than CK-MB (9%) in diagnosing blunt cardiac injury. Troponin<br />
T showed a sensitivity of 27% and a specificity of 91% in 71 patients for predicting clinically<br />
significant ECG changes [67].<br />
In a more current prospective study of 94 patients, 26 patients were diagnosed with blunt cardiac<br />
injury either by ECG or echocardiography. Troponin I and T showed a sensitivity of 23 and<br />
12%, respectively, sensitivity of 97 and 100%, respectively, and a negative predictive value of<br />
76.5 and 74%, respectively. The authors describe an unsatisfactory correlation between the two<br />
enzymes and the occurrence of complications [68]. In another prospective study, sensitivity,<br />
specificity, and the positive and negative predictive values of troponin I are given as 63, 98, 40,<br />
and 98%, respectively, for detecting blunt cardiac injury [69]. Velmahos et al. carried out ECG<br />
tests and troponin I measurements prospectively in 333 patients with blunt chest trauma [70]. In<br />
44 diagnosed cardiac injuries, the ECG and troponin I showed a sensitivity of 89 and 73%,<br />
Emergency room – Abdomen 162
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
respectively, and a negative predictive value of 98% and 94%, respectively. The combination of<br />
ECG and troponin I produced a sensitivity and a negative predictive value of 100% each. Rajan<br />
et al. [71] showed that a cTnI level below 1.05 µg/l at admission and after 6 hours excludes<br />
myocardial injury.<br />
The results available to date show that troponin I in particular is a more specific indicator than<br />
CK-MB for the presence of a blunt cardiac injury. However, the importance of troponin in<br />
predicting complications is still the subject of current discussion.<br />
A transthoracic echocardiography (TTE) is often carried out in the diagnosis of blunt cardiac<br />
injury but has hardly any importance in patients with stable circulation. In a prospective study,<br />
Beggs et al. carried out TTE in 40 patients with suspected blunt chest injury. Half of the patients<br />
had at least one pathologic finding either in the ECG, in the cardiac enzymes or in TTE. There<br />
was no correlation between TTE, the enzyme or ECG findings, and TTE could not predict the<br />
development of complications [72]. In another prospective study of 73 patients who all<br />
underwent TTE, CK-MB measurements, and cardiac monitoring, 14 patients presented<br />
abnormalities in the echocardiography. However, only 1 patient who initially had a pathologic<br />
ECG developed a complication in the form of a ventricular arrhythmia [73]. A prospective study<br />
of 172 patients came to the conclusion that only an abnormal ECG or shock has a predictive<br />
value with reference to monitoring or to a specific treatment. Patients with abnormalities in TTE<br />
or elevated CK-MB levels without a simultaneous pathologic ECG developed no complications<br />
requiring treatment [58]. Although there are a number of studies which show the benefit of TTE<br />
in the diagnosis of pericardial effusion or of pericardial tamponade in penetrating trauma, the<br />
benefit of this study on blunt trauma is debatable [30, 58, 74].<br />
There are a number of studies which show that the accuracy of transesophageal<br />
echocardiography (TEE) is greater than that of TTE in the diagnosis of cardiac injuries [75-79].<br />
In addition, other cardiovascular changes such as aortic injuries, for example, can be diagnosed<br />
by TEE. Vignon et al. [80] prospectively carried out helical CT and, in the intensive care unit,<br />
TEE on 95 patients with risk factors for an aortic injury. The sensitivity of TEE and CT was 93<br />
and 73%, respectively, the negative predictive value was 99% and 95%, respectively, and the<br />
specificity and the positive predictive value were 100% for both examination methods. TEE<br />
proved to be superior in identifying intimal tears whereas an aortic branch lesion was missed.<br />
In summary, echocardiography should be carried out if a pericardial tamponade or pericardial<br />
rupture is suspected.<br />
What additional diagnostic tests exist for emergency room patients?<br />
Fabian et al. [36] state that patients with a mediastinal hematoma and no direct evidence of an<br />
aortic injury require no further assessment. This also applies to intimal tears and pseudoaneurysms.<br />
However, patients with changes that cannot be classified in more detail should<br />
undergo angiography for further assessment. Gavant et al. [35] also stated that, in the absence of<br />
a mediastinal hematoma or if the aorta presented normally despite mediastinal hematoma, helical<br />
CT with contrast agent was sufficient for diagnosis and aortography was not necessary.<br />
Emergency room – Abdomen 163
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Mirvis et al. [43] and Dyer et al [44] suggest that an aortic injury detected in a CT or an injury to<br />
the main lateral branches and a mediastinal hematoma require either an angiography or direct<br />
thoracotomy depending on the experience of the establishment concerned. Angiography is also<br />
necessary for a mediastinal hematoma in direct contact with the aorta or with the proximal great<br />
vessels without direct evidence of a vessel injury or for abnormal aortic contours [37].<br />
Downing et al. [42] conclude from the results of their study that surgical treatment can be carried<br />
out without further diagnostic tests if a helical CT clearly detects an aortic rupture. In contrast to<br />
the above-mentioned study by Dyer et al. [2], Fabian et al. [36] conclude that patients with a<br />
mediastinal hematoma but no direct evidence of an aortic injury require no further work-up.<br />
To date, there are no comparative studies which investigate the necessity of additional<br />
angiography prior to a planned intervention for an aortic injury detected in a CT scan. For this<br />
reason, the recommendations are based, on the one hand, on conclusions from studies which<br />
evaluated angiography and CT in the diagnosis of aortic injury and, on the other hand, on data<br />
from diagnostic tests carried out prior to endovascular treatment.<br />
Thus, Gavant et al. [35], recommend that aortography is carried out prior to surgical or<br />
endovascular treatment in order to confirm the injury and define the extent of the damage. Parker<br />
et al. [37] also consider angiography necessary for confirming positive CT findings.<br />
In patients with direct indication of an aortic injury and a mediastinal hematoma, Mirvis et al.<br />
[43] and Dyer et al [44] suggest either angiography or direct thoracotomy depending on the<br />
experience of the establishment concerned.<br />
Downing et al. [42] and Fabian et al. [36] hold the view that a thoracotomy can also be carried<br />
out without additional angiography if the CT finding is clear.<br />
In a series of 5 patients with acute traumatic rupture of the thoracic aorta, a CT scan and<br />
angiography were carried out on all patients prior to stent implantation [81].<br />
What importance is attached to emergency procedures (chest drain, intubation,<br />
pericardiocentesis, thoracotomy)?<br />
Key recommendations:<br />
A clinically relevant or progressive pneumothorax must first be decompressed<br />
in the ventilated patient.<br />
A progressive pneumothorax should be decompressed in the non-ventilated<br />
patient.<br />
GoR A<br />
GoR B<br />
A chest drain must be inserted for this purpose. GoR A<br />
Preference should be given to wide lumen chest drains. GoR B<br />
Emergency room – Abdomen 164
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Explanation:<br />
A pneumothorax detected in the radiographic image represents an indication to insert a chest<br />
drain particularly if mechanical ventilation is necessary. This represents general clinical practice<br />
although there are no comparative studies on this in the literature [12, 82-85]. Due to the<br />
underlying pathophysiology, it is upgraded to Grade of Recommendation A. Westaby and<br />
Brayley [86] recommend that a chest drain should always be inserted for a pneumothorax which<br />
exceeds 1.5 cm in size and is at the level of the 3rd intercostal space. If the size is less than 1.5<br />
cm, a chest drain should only be inserted if ventilation is necessary or if there is bilateral<br />
occurrence. The insertion of a chest drain can be omitted only in small ventral pneumothoraces<br />
detected by CT although close clinical monitoring is required.<br />
The insertion of a chest drain should be carried out in the emergency room as the risk of a<br />
progressive pneumothorax can lead to a tension pneumothorax and the timespan of such a<br />
development cannot be estimated. The risk of a tension pneumothorax occurring should be rated<br />
markedly higher in ventilated patients than in non-ventilated patients. In non-ventilated patients,<br />
small pneumothoraces less than 1-1.5 cm in width can initially be treated conservatively by close<br />
clinical monitoring. If this is not possible for logistic reasons, the pneumothorax should also be<br />
decompressed in this situation.<br />
The increasing use of abdominal and chest CT in the diagnosis of blunt trauma has led to<br />
pneumothoraces being detected in a CT scan which had not been detected previously by<br />
conventional supine radiographic images. These so-called occult pneumothoraces, usually lying<br />
ventrally, are found in 2-25% of patients after severe multiple injuries [19, 22, 23, 87-89]. Based<br />
on the available literature, the initial insertion of a Bülau drain should be omitted in an occult<br />
pneumothorax diagnosed by CT if:<br />
� the patients are hemodynamically stable and have a largely normal lung function,<br />
� there are frequent clinical checks with the possibility of radiography in between<br />
and<br />
� a chest drain can be inserted at any time by a qualified physician.<br />
Also in a prospective randomized study, Brasel et al. [91] studied the necessity of inserting a<br />
chest drain for an occult traumatic pneumothorax. Chest drains were inserted in 18 patients while<br />
21 patients were clinically observed only. Ventilation was necessary in 9 patients in each group.<br />
In the group with chest drains, the pneumothorax increased in 4 patients; in the group without<br />
chest drain, a Bülau drain was inserted in 3 patients, of whom 2 patients were then also<br />
ventilated.<br />
In a prospective study of 36 patients with 44 occult pneumothoraces, the subdivision was made<br />
into minimal (< 1 cm visible on a maximum of 4 CT slices), anterior (> 1 cm but not extending<br />
laterally into the dorsal half of the chest), and anterolateral pneumothoraces [92]. Fifteen<br />
minimal pneumothoraces were closely clinically monitored irrespective of the necessity for<br />
ventilation. The secondary insertion of a chest drain was then required in 2 cases. A drain was<br />
Emergency room – Abdomen 165
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
always inserted for anterior and anterolateral pneumothoraces if ventilation was required. In a<br />
prospective study of children, Holmes et al. identified 11 patients with occult pneumothoraces<br />
which were also subdivided according to the above-mentioned plan [93]. In the case of minimal<br />
pneumothoraces, the patients were also conservatively treated irrespective of the necessity for<br />
ventilation.<br />
In a retrospective study, patients with pneumothorax were treated with (13) and without (13) a<br />
chest drain [94]. Out of 10 patients who required mechanical ventilation, 2 patients had to have a<br />
secondary chest drain inserted. However, there are no data on the size of the initial<br />
pneumothorax. In another retrospective study, the size of the occult pneumothorax was<br />
compared against the requirement to insert a chest drain and it was suggested that<br />
pneumothoraces less than 5 x 80 mm could be observed irrespective of the necessity for<br />
mechanical ventilation [95]. Weißberg et al. [96] stated in their retrospective study of 1,199<br />
patients (of whom 403 patients had traumatic pneumothorax) that management by clinical<br />
observation is possible for a pneumothorax volume less than 20% of the pleural space. However,<br />
there are no details on the effect of possible mechanical ventilation.<br />
A score was proposed by De Moya for the improved definition of the “small” pneumothorax,<br />
which is composed of 2 parts: 1) the largest diameter of the pneumothorax and 2) its relationship<br />
to the pulmonary hilus. If the pneumothorax does not exceed the pulmonary hilus, 10 is added to<br />
the millimeter figure of the pneumothorax; if the hilus is exceeded, 20 is added. The sum of the<br />
individual values for each side gives the score value. The positive predictive value for a chest<br />
drain was 78% for a score > 30 and the negative predictive value was 70% for a score < 20<br />
[136]. In a randomized study of 21 ventilated patients, observation of the occult pneumothorax<br />
proved to be reliable. In 13 patients initially treated without a chest drain, there was no need for<br />
emergency decompression in any case even though pleural effusion had to be decompressed<br />
during the course in 2 patients and an increasing pneumothorax had to be decompressed after<br />
insertion of a central venous catheter in one patient. It seems justifiable to take a “wait and see”<br />
attitude towards inserting a chest drain for an occult pneumothorax both in spontaneously<br />
breathing and ventilated patients [129, 130].<br />
Key recommendation:<br />
Pericardial decompression should be carried out if there is evidence of<br />
pericardial tamponade and acute deterioration in vital parameters.<br />
Explanation:<br />
GoR B<br />
Irrespective of the patient’s condition, the diagnosis of pericardial tamponade should be made<br />
rapidly and reliably so that surgery can be performed quickly if required. Although the diagnosis<br />
of tamponade can be confirmed by the insertion of a pericardial window, this is an invasive<br />
procedure, particularly if there is only slight suspicion of a cardiac injury. Ultrasound<br />
examination has been proven to be a sensitive procedure in the diagnosis of pericardial effusion<br />
and thus represents the current method of choice. In a prospective multicenter study of 261<br />
patients with penetrating pericardial chest injuries, there was a sensitivity of 100%, a specificity<br />
Emergency room – Abdomen 166
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
of 96.7%, and an accuracy of 97% [30]. There were no false-negative study results. In another<br />
study, fluid was detected by ultrasound scan in the pericardium in 3 cases out of 34 patients. One<br />
patient, who was hemodynamically unstable, underwent a thoracotomy and the other two<br />
patients had a negative pericardial window [105].<br />
Pericardiocentesis is now of lesser importance in the diagnosis of pericardial tamponade, having<br />
been replaced by ultrasound examination [30, 106].<br />
Emergency room – Abdomen 167
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
A thoracotomy can be performed if there is an initial blood loss of > 1,500 ml<br />
from the chest drain or if there is persistent blood loss of > 250 ml/h over more<br />
than 4 hours.<br />
Explanation:<br />
GoR 0<br />
The indication for thoracotomy depending on the volume of initial or continuous blood loss from<br />
the chest drain has been intensely discussed by the guideline group, not least because of the<br />
inconsistent volumes described in the literature. These are almost exclusively cohort studies on<br />
penetrating trauma; randomized studies are not available on this research question. The available<br />
data is considerably less clear for blunt trauma; a thoracotomy is indicated rather less frequently<br />
and usually later than for penetrating trauma. Under certain circumstances, with a certain volume<br />
of blood loss, the thoracotomy can also be useful in hemodynamically stable patients. There are<br />
no data on coagulation status as a decision criterion but body temperature can be taken into<br />
account.<br />
In the 1970s, based on the experiences of penetrating injuries in the Vietnam War, McNamara et<br />
al. [107] described a reduction in mortality after early thoracotomy. Indication criteria for<br />
thoracotomy were given as an initial blood loss after chest drainage of 1,000-1,500 ml and a<br />
blood loss of 500 ml during the first hour after insertion of the drain.<br />
Kish et al. [108] analyzed 59 patients in whom one thoracotomy was necessary. A thoracotomy<br />
was performed in 4 out of 44 patients with penetrating injuries and in 2 out of 15 patients with<br />
blunt trauma 6-36 hours after the accident where there was continuous bleeding of 150 ml/hour<br />
over more than 10 hours or 1,500 ml over a shorter time span. The strategy of performing a<br />
thoracotomy where there is an initial blood loss of > 1,500 ml after insertion of a chest drain or a<br />
continuous hourly blood loss of > 250 ml over 4 hours is accepted for penetrating injuries [109].<br />
In a multicenter study of 157 patients who had a thoracotomy because of chest bleeding, there<br />
was a correlation between mortality and the level of thoracic blood loss [110]. With a blood loss<br />
of 1,500 ml compared to 500 ml, the mortality risk was increased by the factor 3.2. The authors<br />
thus conclude that a thoracotomy should be considered in patients with penetrating and blunt<br />
trauma with a thoracic blood loss of 1,500 ml in the first 24 hours after admission even if there<br />
are no signs of hemorrhagic shock.<br />
In the current version of the NATO Handbook [111], an initial blood loss of 1,500 ml and<br />
drainage of 250 ml over more than 4 hours are given as indication for a thoracotomy. The<br />
different volumes given as threshold values for indicating a thoracotomy were checked by the<br />
guideline group. Agreement was reached on the volume laid down in the recommendation of<br />
> 1,500 ml initially or > 250 ml/h over more than 4 hours.<br />
Key recommendation:<br />
Emergency room – Abdomen 168
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
An emergency thoracotomy should not be performed in the emergency room<br />
on patients with blunt trauma and absence of vital signs at the accident scene.<br />
Explanation:<br />
GoR B<br />
If vital signs are absent at the accident scene, an emergency thoracotomy is not indicated in the<br />
emergency room for patients with blunt trauma. Vital signs include pupillary reaction to light,<br />
any type of spontaneous breathing, movement caused by painful stimulus or supraventricular<br />
activity in the ECG [112]. However, if cardiac arrest only develops on admission to hospital, an<br />
immediate thoracotomy should be performed particularly in the case of penetrating trauma.<br />
Boyd et al. carried out a retrospective study of 28 patients who underwent a thoracotomy in the<br />
emergency room for the purpose of resuscitation. A meta-analysis was also carried out [112].<br />
The survival rate was 2 out of 11 patients with penetrating trauma and 0 out of 17 patients with<br />
blunt trauma, with the survival rate (2 out of 3 patients) being highest if vital signs were present<br />
both at the accident scene and in the emergency room. A meta-analysis of 2,294 patients yielded<br />
a survival rate of 11% with the survival rate being significantly better after penetrating trauma<br />
compared to blunt trauma (14% versus 2%). There were no survivors in the patient group with<br />
absent vital signs at the accident scene and there were no survivors of blunt trauma without<br />
neurologic deficit among the patients with absent vital signs in the emergency room.<br />
Velhamos et al. [113] retrospectively analyzed 846 patients, who underwent an emergency<br />
thoracotomy in the emergency room. All patients presented a loss of vital signs at the time of<br />
admission or cardiac arrest in the emergency room. Out of 162 patients who were successfully<br />
resuscitated, it was possible to discharge 43 (5.1%) from hospital with 38 of these patients<br />
having no neurologic deficit. Out of 176 patients with blunt trauma, only 1 patient (0.2%)<br />
survived with serious neurologic deficits.<br />
Branney et al. [114] found an overall survival rate of 4.4% in 868 patients who underwent<br />
emergency thoracotomy. Eight out of 385 patients with blunt trauma survived (2%). Of these, 4<br />
patients had no neurologic deficit. Out of patients with blunt trauma and absent vital signs at the<br />
accident scene, 2 patients survived with serious neurologic deficit. In contrast, the outcome for<br />
absent vital signs at the accident scene and penetrating trauma was markedly better with 12<br />
neurologically-intact surviving patients out of 355. This result differs markedly from the abovementioned<br />
meta-analysis by Boyd et al. [112] and later studies by Esposito et al. [115],<br />
Mazzorana et al. [116], Brown et al. [117], and Lorenz et al. [118], which described no surviving<br />
patients among those with penetrating trauma and absent vital signs.<br />
Another retrospective study of 273 thoracotomies performed in the emergency room yielded 10<br />
surviving patients without neurologic deficit [119]. These all had penetrating injuries and<br />
presented vital signs either at the accident scene or in the emergency room. Out of 21 patients<br />
with blunt trauma, no patient survived. The authors thus conclude that an emergency room<br />
thoracotomy should only be performed on patients with penetrating trauma who show vital signs<br />
either at the accident scene or in the emergency room. Out of 19 patients with blunt trauma,<br />
Grove et al. [120] were also unable to list any surviving patients after an emergency<br />
Emergency room – Abdomen 169
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
thoracotomy. On admission, 5 of these patients showed no vital signs and 14 patients showed<br />
vital signs. All patients died within 4 days. The survival rate for penetrating trauma was 3 out of<br />
10 patients.<br />
Based on a meta-analysis of 42 outcome studies with a total of 7,035 documented “Emergency<br />
Department Thoracotomies”, the American College of Surgeons has published a guideline on the<br />
indication and performance of an emergency room thoracotomy [131]. The resulting statements<br />
are based chiefly on the finding that, with an overall survival rate of 7.8%, only 1.6% of patients<br />
survived after blunt trauma but 11.2% after penetrating trauma. More recent studies have also<br />
confirmed that an emergency thoracotomy during cardiopulmonary resuscitation (CPR) can<br />
improve the prognosis particularly in the case of penetrating trauma and appears to be<br />
particularly expedient if vital signs are initially present [132, 133, 134, 135].<br />
Emergency room – Abdomen 170
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Literature:<br />
1. Horton T, Cohn S, Heid M, Augenstein J, Bowen J,<br />
McKenney M, et al. Identification of trauma patients<br />
at risk of thoracic aortic tear by mechanism of injury.<br />
J Trauma 2000;48:1008-1013 [LoE 2b].<br />
2. Dyer D, Moore E, Ilke D, McIntyre R, Bernstein S,<br />
Durham J, et al. Thoracic aortic injury: how predictive<br />
is mechanism and is chest computed tomography a<br />
reliable screening tool? A prospective study of 1,561<br />
patients. J Trauma 2000;48:673-682 [LoE 2b].<br />
3. Richter M, Krettek C, Otte D, Wiese B, Stalp M,<br />
Ernst S, et al. Correlation between crash severity,<br />
injury severity , and clinical course in car occupants<br />
with thoracic trauma: a technical and medical study. J<br />
Trauma 2001;50:10-16 [LoE 2b].<br />
4. Ruchholtz S, Nast-Kolb D, Waydhas C, Schweiberer<br />
L. Das Verletzungsmuster beim <strong>Polytrauma</strong>.<br />
Unfallchirurg 1996;99:633-641 [LoE 4].<br />
5. Pattimore D, Thomas P, Dave S. Torso injury patterns<br />
and mechanisms in car crashes: an additional<br />
diagnostic tool. Injury 1992;23:123-126 [LoE 2b].<br />
6. Siegel J, Smith J, Siddiqi S. Change in Velocity and<br />
Energy Dissipation on Impact in Motor Vehicle<br />
Crashes as a Function of the Direction of Crash: Key<br />
Factors in the Production of Thoracic Aortic Injuries,<br />
Their Pattern of Associated Injuries and Patient<br />
Survival A Crash Injury Research Engineering<br />
Network (CIREN) Study. J Trauma 2004;57:760-778<br />
[LoE 2b].<br />
7. Orzechowski K, Edgerton E, Bulas D, McLaughlin P,<br />
Eichelberger M. Patterns of injury to restrained<br />
children in side impact motor vehicle crashes: the side<br />
impact syndrome. J Trauma 2003;54:1094-1101 [LoE<br />
2b].<br />
8. Porter R, Zhao N. Patterns of injury in belted and<br />
unbelted individuals presenting to trauma center after<br />
motor vehicle crash: seat belt syndrome revisted. Ann<br />
Emerg Med 1998;32:418-424 [LoE 2b].<br />
9. Bokhari F, Brakenridge S, Nagy K, Roberts R, Smith<br />
R, Joseph K, et al. Prospective evaluation of the<br />
sensitivity of physical examination in chest trauma. J<br />
Trauma 2002;53:1135-1138 [LoE 2b].<br />
10. Chen S, Markmann J, Kauder D, William S.<br />
Hemopneumothorax missed by auscultation in<br />
penetrating chest injury. J Trauma 1997;42:86-89<br />
[LoE 2b].<br />
11. Hirshberg A, Thomson S, Huinzinga K. Reliability of<br />
physical examination in penetrating chest injuries.<br />
Injury 1988;19(6):407-409 [LoE 2b].<br />
12. Holmes J, Sokolove P, Brant W, Kuppermann N. A<br />
clinical decision rule for identifying children with<br />
thoracic injuries after blunt torso trauma. Ann Emerg<br />
Med 2002;39:492-499 [LoE 2b].<br />
13. Greenberg M, Rosen C. Evaluation of the patient with<br />
blunt chest trauma: an evidence based approach.<br />
Emerg Med Clin North Am 1999;17:41-62.<br />
14. Hehir M, Hollands M, Deane S. The accuracy of the<br />
first chest x-ray in the trauma patient. Aust N Z J Surg<br />
1990;60:529-532 [LoE 2b].<br />
15. McLellan B, Ali J, Towers M, Sharkey W. Role of the<br />
trauma-room chest x-ray film in assessing the patient<br />
with severe blunt traumatic injury. Can J Surg<br />
1996;39:36-41 [LoE 2b].<br />
16. Peytel E, Menegaux F, Cluzel P, Langeron O, Coriat<br />
P, Riou B. Initial imaging assessment of severe blunt<br />
trauma. Intensive Care Med 2001;27:1756-1761 [LoE<br />
2b].<br />
17. Okamoto K, Norio H, Kaneko N, Sakamoto T, Kaji T,<br />
Okada Y. Use of early-phase dynamic spiral<br />
computed tomography for the primary screening of<br />
multiple trauma. Am J Emerg Med 2002;20:528-534<br />
[LoE 2b].<br />
18. Klöppel R, Schreiter D, Dietrich J, Josten C, Kahn T.<br />
Frühes klinisches Management nach <strong>Polytrauma</strong> mit<br />
1- und 4-Schicht-Spiral-CT. Radiologe 2002;42:541-<br />
546 [LoE 2b].<br />
19. Trupka A, Kierse R, Waydhas C, Nast-Kolb D, Blahs<br />
U, Schweiberer L, et al. Schockraumdiagnostik beim<br />
<strong>Polytrauma</strong> - Wertigkeit der Thorax CT. Unfallchirurg<br />
1997;100:469-476 [LoE 2b].<br />
20. Exadaktylos AK, Sclabas G, Schmid SW, Schaller B,<br />
Zimmermann H. Do we really need routine computed<br />
tomographic scanning in the primary evaluation of<br />
blunt chest trauma in patients with "normal" chest<br />
radiograph? J Trauma 2001;51:1173-1176 [LoE 2b].<br />
21. Demetriades D, Gomez H, Velmahos G, Asensio J,<br />
Murray J, Cornwell E, et al. Routine helical computed<br />
tomographic evaluation of the mediastinum in highrisk<br />
blunt trauma patients. Arch Surg 1998;133:1084-<br />
1088 [LoE 2b].<br />
22. Omert L, Yeaney WW, Protetch J. Efficacy of<br />
thoracic computerized tomography in blunt chest<br />
trauma. Am Surg 2001;67:660-664 [LoE 2b].<br />
23. Blostein P, Hodgman C. Computed tomography of the<br />
chest in blunt thoracic trauma: results of a prospective<br />
study. J Trauma 1997;43:13-18 [LoE 2b].<br />
24. Renton J, Kincaid S, Ehrlich P. Should helical CT<br />
scanning of the thoracic cavity replace the<br />
conventional chest x-ray as a primary assessment tool<br />
in pediatric trauma? An efficacy and cost analysis. J<br />
Pediatr Surg 2003;38:793-797 [LoE 2b].<br />
25. Grieser T, Bühne KH, Häuser H, Bohndorf K.<br />
Relevanz der Befunde von Thoraxröntgen und<br />
Thorax-CT im routinemäßigen Schockraumeinsatz bei<br />
102 polytraumatisierten Patienten. Eine prospektive<br />
Studie. Fortschr Röntgenstr 2001;173:44-51.<br />
26. Guerrero-Lopez F, Vazquez-Mata G, Alcazar-Romero<br />
P, Fernandez-Mondejar E, Aguayo-Hoyos E, Linde-<br />
Valverde C. Evaluation of the utility of computed<br />
tomography in the initial assessment of the critical<br />
care patient with chest trauma. Crit Care Med<br />
2000;28:1370-1375 [LoE 2b].<br />
27. Rowan K, Kirkpatrick A, Liu D, Forkheim K, Mayo J,<br />
Nicolaou S. Traumatic pneumothorax detection with<br />
thoracic US: correlation with chest radiography and<br />
CT - initial experience. Radiology 2002;225:210-214<br />
[LoE 2b].<br />
Emergency room – Abdomen 171
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
28. Dulchavsky S, Schwarz K, Kirkpatrick A, Billica R,<br />
Williams D, Diebel L, et al. Prospective evaluation of<br />
thoracic ultrasound in the detection of pneumothorax.<br />
J Trauma 2001;50:201-205 [LoE 2b].<br />
29. Ma J, Mateer J. Trauma ultrasound examination<br />
versus chest radiography in the detection of<br />
hemothorax. Ann Em Med 1997;29:312-316 [LoE 2b]<br />
30. Rozycki G, Feliciano D, Ochsner M, Knudson M,<br />
Hoyt D, Davis F, et al. The role of ultrasound in<br />
patients with possible penetrating cardiac wounds: a<br />
prospective multicenter study. J Trauma 1999;46:543-<br />
552 [LoE 2b].<br />
31. Meyer D, Jessen M, Grayburn P. Use of<br />
echocardiography to detect occult cardiac injury after<br />
penetrating thoracic trauma: a prospective study. J<br />
Trauma 1995;39:907-909 [LoE 2b].<br />
32. Durham R, Zuckerman D, Wolverson M, Heiberg E,<br />
Luchtefeld W, Herr D, et al. Computed tomography as<br />
a screening exam in patients with suspected blunt<br />
aortic injury. Ann Surg 1994; 220: 699-704.<br />
33. Miller F, Richardson J, Thomas H, Cryer H, Willing<br />
S. Role of CT in diagnosis of major arterial injury<br />
after blunt thoracic trauma. Surgery 1989; 106: 596-<br />
602.<br />
34. Fisher R, Chasen M, Lamki N. Diagnosis of injuries<br />
of the aorta and brachiocephalic arteries caused by<br />
blunt chest trauma: CT vs aortography. Am J<br />
Roentgenol 1994;162:1047-1052.<br />
35. Gavant M, Menke P, fabian T, Flick P, Graney M,<br />
Gold R. Blunt traumatic aortic rupture: detection with<br />
helical CT of the chest. Radiology 1995;197:125-133<br />
[LoE 2b].<br />
36. Fabian T, Davis K, Gavant M, Croce M, Melton S,<br />
Patton J, et al. Prospective study of blunt aortic injury:<br />
helical CT is diagnostic and antihypertensive therapy<br />
reduces rupture. Ann Surg 1998;227:666-677 [LoE<br />
2b].<br />
37. Parker M, Matheson T, Rao A, Sherbourne C, Jordan<br />
K, Landay M, et al. Making the transition: the role of<br />
helical CT in the evaluation of potentially acute<br />
thoracic aortic injuries. Am J Roentgenol<br />
2001;176:1267-1272 [LoE 2b].<br />
38. Tello R, Munden R, Hooton S, Kandapra K, Pugatch<br />
R. Value of spiral CT in hemodynamically stable<br />
patients following blunt chest trauma. Comput Med<br />
Imaging Graph 1998;22:557-452 [LoE 3b].<br />
39. Raptopoulos V, Sheiman R, Philipps D, Davidoff A,<br />
Silva W. Traumatic aortic tear: screening with chest<br />
CT. Radiology 1992;182:667-673.<br />
40. Mirvis S, Shanmuganathan K, Miller B, White C,<br />
Turney S. Traumatic aortic injury: diagnosis with<br />
contrast enhanced thoracic CT - five year experiance<br />
at a major trauma center. Radiology 1996;200:413-<br />
422 [LoE 2b].<br />
41. von Segesser L, Fischer A, Vogt P, Turina M.<br />
Diagnosis and management of blunt great vessel<br />
trauma. J Card Surg 1997;12:181-186.<br />
42. Downing S, Sperling J, Mirvis S, Cardarelli M,<br />
Gilbert T, Scalea T, et al. Experience with spiral<br />
computed tomography as the sole diagnostic method<br />
for traumatic aortic rupture. Ann Thorac Surg<br />
2001;72:495-502 [LoE 2b].<br />
43. Mirvis S, Shanmuganathan K, Buell J, Aurelio R. Use<br />
of spiral computed tomography for the assessment of<br />
blunt trauma patients with potential aortic injury. J<br />
Trauma 1998;45:922-930 [LoE 2b].<br />
44. Dyer D, Moore E, Mestek M, Bernstein S, Ikle D,<br />
Durham J, et al. Can chest CT be used to exclude<br />
aortic injury? Radiology 1999;213:195-202 [LoE 2b]<br />
45. Collier B, Hughes K, Mishok K, Kraner G, Rodriguez<br />
A. Is helical computed tomography effective for<br />
diagnosis of blunt aortic injury? Am J Emerg Med<br />
2002;20:558-561 [LoE 2b].<br />
46. Vignon P, Lagrange P, Boncoeur M, Francois B,<br />
Gastinne H, Lang R. Routine transesophageal<br />
echocardiography for the diagnosis of aortic<br />
disruption in trauma patients without enlarged<br />
mediastinum. J Trauma 1996;40:422-427.<br />
47. Brooks S, Young J, Cmolik B, Schina M, Dianzumba<br />
S, Townsend R, et al. The use of transesophageal<br />
echocardiography in the evaluation of chest trauma. J<br />
Trauma 1992;32:761-768.<br />
48. Cohn S, Burns G, Jaffe C, Milner K. Exclusion of<br />
aortic tear in the unstable trauma patient: the utility of<br />
transesophageal echocardiography. J Trauma<br />
1995;39:1087-1090.<br />
49. Buckmaster M, Kearney P, Johnson S, Smith M,<br />
Sapin P. Further experience with transesophageal<br />
echocardiography in the evaluation of thoracic aortic<br />
injury. J Trauma 1994;37:989-995.<br />
50. Minard G, Schurr M, Croce M, Gavant M, Kudsk K,<br />
Taylor M, et al. A prospective analysis of<br />
transesophageal echocardiography in the diagnosis of<br />
traumatic disruption of the aorta. J Trauma 1996;40:<br />
225-230.<br />
51. Goarin J, Catoire P, Jacquens Y, Saada M, Riou B,<br />
Bonnet F, et al. Use of transesophageal<br />
echocardiography for diagnosis of traumatic aortic<br />
injury. Chest 1997;112:71-80.<br />
52. Mollod M, Felner J. Transesophageal<br />
echocardiography in the evaluation of cardiothoracic<br />
trauma. Am Heart J 1996;132:841-849.<br />
53. Maenza R, Seaberg D, DiAmico F. A meta-analysis of<br />
blunt cardiac trauma: Ending myocardial confusion.<br />
Am J Emerg Med 1996;14:237-241 [LoE 1b].<br />
54. Fildes F, Betlej T, Mangliano R, al e. Limiting cardiac<br />
evaluations in patients with suspected myocardial<br />
contusion. Am Surg 1995;61:832-835 [LoE 2b].<br />
55. Dowd M, Krug S. Pediatric blunt cardiac injury:<br />
Epidemiology, clinical features, and diagnosis.<br />
Pediatric emergency medicine collaborative research<br />
committee: Working group on blunt cardiac injury. J<br />
Trauma 1996;40:61-67 [LoE 2b].<br />
56. Biffl W, Moore F, Moore E. Cardiac enzymes are<br />
irrelevant in the patient with suspected myocardial<br />
contusion. Am J Surg 1994;168:523-527 [LoE 2b].<br />
57. Faller JP, Feissel M, Kara A, Camelot R, Simon G.<br />
[Ventilation in prone position in acute respiratory<br />
distress syndrome of severe course. 3 cases (letter)].<br />
Presse Med 1988;17(22): 1.154 [LoE 4].<br />
58. Miller F, Shumate C, Richardson J. Myocardial<br />
contusion: When can the diagnosis be eliminated?<br />
Arch Surg 1989;124:805-807 [LoE 2b].<br />
Emergency room – Abdomen 172
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
59. Wisner D, Reed W, Riddick R. Suspected myocardial<br />
contusion: Triage and indications for monitoring. Ann<br />
Surg 1990;212:82-86 [LoE 2b]<br />
60. Fabian T, Cicala R, Croce M. A prospective<br />
evaluation of myocardial contusion: Correlation of<br />
significant arrhythmias and cardiac output with CPK-<br />
MB measurements. J Trauma 1991;31:653-659 [LoE<br />
2b]<br />
61. Gunnar W, Martin M, Smith R. The utility of cardiac<br />
evaluation in the hemodynamically stable patient with<br />
suspected myocardial contusion. Am Surg<br />
1991;57:373-374.<br />
62. Helling T, Duke P, Beggs C. A prospective evaluation<br />
of 68 patients suffering blunt chest trauma for<br />
evidence of cardiac injury. J Trauma 1989;29:961-<br />
965.<br />
63. Keller K, Shatney C. Creatin-phosphokinase-MB<br />
assays in patients with suspected myocardial<br />
contusion: Diagnostic test or test of diagnosis. J<br />
Trauma 1988;28:58-63.<br />
64. Soliman M, Waxman K. Value of a conventional<br />
approach to the diagnosis of traumatic cardiac<br />
contusion after chest injury. Crit Care Med<br />
1987;15:218-220.<br />
65. Frazee R, Mucha P, Farnell M. Objective evaluation<br />
of blunt cardiac trauma. J Trauma 1986;26:510.<br />
66. Adams J, Davila-Roman V, Bessey P. Improved<br />
detection of cardiac contusion with cardiac troponin I.<br />
Am Heart J 1996;131:308-312.<br />
67. Fulda G, Gilberson F, Hailstone D. An evaluation of<br />
serum troponin T and signal-averaged<br />
electrocardiography in predicting electrocardiographic<br />
abnormalities after blunt chest trauma. J Trauma<br />
1997;43:304310.<br />
68. Bertinchant J, Polge A, Mohty D, Nguyen-Ngoc-Lam<br />
R, Estorc J, Cohendy R, et al. Evaluation of incidence,<br />
clinical significance, and prognostic value of<br />
circulating cardiac troponin I and T elevation in<br />
hemodynamically stable patients with suspected<br />
myocardial contusion after blunt chest trauma. J<br />
Trauma 2000;48:924-931 [LoE 2b]<br />
69. Edouard A, Felten M, Hebert J, Cosson C, Martin L,<br />
Benhamou D. Incidence and significance of cardiac<br />
troponin I release in severe trauma patients.<br />
Anesthesiology 2004;101:1262-1268 [LoE 2b]<br />
70. Velmahos G, Karaiskakis M, Salim A, Toutouzas K,<br />
Murray J, Asensio J, et al. Normal<br />
electrocardiography and serum troponin I levels<br />
preclude the presence of clinically significant blunt<br />
cardiac injury. J Trauma 2003;54:45-51 [LoE 2b]<br />
71. Rajan GP ZR. Cardiac Troponin I as a Predictor of<br />
Arrhythmia and Ventricular Dysfunction in Trauma<br />
Patients With Myocardial Contusion. J Trauma<br />
2004;57:801-808 [LoE 2b]<br />
72. Beggs C, Helling T, Evans L. Early evaluation of<br />
cardiac injury by two-dimensional echocardiography<br />
in patients suffering blunt chest trauma. Ann Em Med<br />
1987;16:542-545 [LoE 2b]<br />
73. Hiatt J, Yeatman L, Child,JS. The value of<br />
echocardiography in blunt chest trauma. J Trauma<br />
1988;28:914-922 [LoE 2b]<br />
74. Nagy K, Lohmann C, Kim D. Role of<br />
echocardiography in the diagnosis of occult<br />
penetrating cardiac injury. J Trauma 1995;38:859-<br />
862.<br />
75. Chirillo F, Totis O, Cavarzerani A. Usefulness of<br />
transthoracic and transesophageal echocardiography<br />
in recognition and management of cardiovascular<br />
injuries after blunt chest trauma. Heart 1996;75:301-<br />
306.<br />
76. Catoire P, Orliaguet G, Liu N. Systematic<br />
transesophageal echocardiography for detection of<br />
mediastinal lesions in patients with multiple injuries. J<br />
Trauma 1995;38:96-102.<br />
77. Brooks S, Young J, Cmolik B. The use of<br />
transesophageal echocardiography in the evaluation of<br />
chest trauma. J Trauma 1992;32:761-765.<br />
78. Goldberg S, Karalis D, Ross J. Severe right<br />
ventricular contusion mimicking cardiac tamponade:<br />
the value of transesophageal echocardiography in<br />
blunt chest trauma. Ann Emerg Med 1993;22:745-<br />
747.<br />
79. Weiss R, Brier J, O´Connor W. The usefulness of<br />
transesophageal echocardiography in diagnosing<br />
cardiac contusions. Chest 1996;109:73-77.<br />
80. Vignon P, Boncoeur M, Francois B, Rambaud G,<br />
Maubon A, Gastinne H. Comparison of multiplane<br />
transesophageal echocardiography and contrastenhanced<br />
helical CT in the diagnosis of blunt<br />
traumatic cardiovascular injuries. Anesthesiology<br />
2001;94:615-622 [LoE 2b]<br />
81. Thompson C, Rodriguez J, Ramaiah V, DiMugno L,<br />
Shafique S, Olsen D, et al. Acute Traumatic rupture of<br />
the thoracic aorta treated with endoluminal stent<br />
grafts. J Trauma 2002;52:1173-1177 [LoE 3]<br />
82. Adrales G, Huynh T, Broering B, Sing R, Miles W,<br />
Thomason M, et al. A thoracostomy guideline<br />
improves management efficiency in trauma patients. J<br />
Trauma 2002;52:210-216<br />
83. Gambazzi F, Schirren J. Thoraxdrainagen-Was ist<br />
"evidence based" Chirurg 2003;74:99-107.<br />
84. Waydhas C. Thoraxtrauma. Unfallchirurg<br />
2000;103:871-890.<br />
85. Gilbert T, McGrath B, Soberman M. Chest tubes:<br />
indications, placement, management and<br />
complications. J Intensive Care 1993;8:73-86.<br />
86. Westaby S, Brayley N. Thoracic trauma - I. BMJ<br />
1990;300:1639-1643.<br />
87. Tocino I, Miller M, Frederick P, Bahr A, Thomas F.<br />
CT detection of occult pneumothorax in head trauma.<br />
AJR 1984;143:987-990.<br />
88. Rhea JT, Novelline RA, Lawrason J, Sacknoff R, Oser<br />
A. The frequency and significance of thoracic injuries<br />
detected on abdominal CT scans of multiple trauma<br />
patients. J Trauma 1989; 29:502-505.<br />
89. Wall S, Federle M, Jeffrey R, Brett C. CT diagnosis of<br />
unsuspected pneumothorax after blunt abdominal<br />
trauma. AJR 1983;141:919-921.<br />
90. Enderson B, Abdalla R, Frame S, Casey M, Gould H,<br />
Maull K. Tube thoracostomy for occult<br />
pneumothorax: a prospective randomized study of its<br />
use. J Trauma 1993;35:729-730.<br />
Emergency room – Abdomen 173
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
91. Brasel K, Stafford R, Weigelt J, Tenquist J,<br />
Borgstrom D. Treatment of occult pneumothoraces<br />
from blunt trauma. J Trauma 1999;46:987-991 [LoE<br />
1b]<br />
92. Wolfman N, Myers W, Glauser S, Meredith J, Chen<br />
M. Validity of CT classification on management of<br />
occult pneumothorax: a prospective study. AJR<br />
1998;171:1317-1320 [LoE 2b]<br />
93. Holmes J, Brant W, Bogren H, London K,<br />
Kuppermann N. Prevalence and importance of<br />
pneumothoraces visualized an abdominal computed<br />
tomographic scan in children with blunt trauma. J<br />
Trauma 2001;50:516-520 [LoE 2b]<br />
94. Collins J, Levine G, Waxman K. Occult traumatic<br />
pneumothorax: immediate tube thoracostomy versus<br />
expectant management. Am Surg 1992;58:743-746<br />
[LoE 2b]<br />
95. Garramone R, Jacobs L, Sahdev P. An objective<br />
method to measure and manage occult pneumothorax.<br />
Surg Gynecol Obstet 1991(173):257-261 [LoE 2b]<br />
96. Weissberg D, Refaely Y. Pneumothorax - Experience<br />
with 1199 patients. Chest 2000;117:1279-1285 [LoE<br />
4]<br />
97. Richardson J, Adams L, Flint L. Selective<br />
management of flail chest and pulmonary contusion.<br />
Ann Surg 1982;196:481-486.<br />
98. Trupka A, Nast-Kolb D, Schweiberer L. Das<br />
Thoraxtrauma. Unfallchirurg 1998;101:244-258.<br />
99. Trupka A, Waydhas C, Nast-Kolb D, Schweiberer L.<br />
Der Einfluß der Frühintubation auf die Reduktion des<br />
posttraumatischen Organversagens. Unfallchirurg<br />
1995;98:111-117.<br />
100. Kalbe P, Kant C. Erstmaßnahmen am Unfallort aus<br />
der Sicht des Unfallchirurgen. Orthopäde 1988;17:2-<br />
10.<br />
101. Moylan J, Fitzpatrick K, Beyer A, Georgiade G.<br />
Factors improving survival in multisystem trauma<br />
patients. Ann Surg 1988;207:679-685.<br />
102. de Pay A, Hohlbach G, Pursche R. Zum Einfluß der<br />
präklinischen Beatmung auf die Prognose des<br />
<strong>Polytrauma</strong>tisierten. Heft Unfallheilkd 1983;156:209-<br />
216.<br />
103. Prien T, Meyer J, Lawin P. Wertigkeit der<br />
Frühbeatmung beim posttraumatischen Schock. Hefte<br />
Unfallheilkd 1990;212:86-90.<br />
104. Ruchholtz S, Waydhas C, Ose C, Lewan U, Nast-Kolb<br />
D. Prehospital intubation in severe thoracic trauma<br />
without respiratory insufficiency: a matched-pair<br />
analysis based on the trauma registry of the german<br />
trauma society. J Trauma 2002;52:879-886.<br />
105. Boulanger B, Kearney P, Tsuei B, Ochoa J. The<br />
routine use of sonography in penetrating torso injury<br />
is beneficial. J Trauma 2001;51:320-325.<br />
106. Thourani V, Feliciano D, Cooper W, Brady K, Adams<br />
A, Rozycki G, et al. Penetrating cardiac trauma at an<br />
urban trauma center: a 22-year perspective. Am Surg<br />
1999;65:811-816.<br />
107. McNamara J, Messersmith J, Dunn R, Molot M,<br />
Stremple J. Thoracic injuries in combat casualties in<br />
Vietnam. Ann Thorac Surg 1970;10:389-401 [LoE<br />
2b]<br />
108. Kish G, Kozloff L, Joseph W, Adkins P. Indications<br />
for early thoracotomy in the management of chest<br />
trauma. Ann Thorac Surg 1976;22:23-28 [LoE 2b]<br />
109. Mansour M, Moore E, Moore F, Read R. Exigent post<br />
injury thoracotomy analysis of blunt vs. penetrating<br />
trauma. Surg Gynecol Obst 1992;175:97-101.<br />
110. Karmy-Jones R, Jurkovich G, Nathens A, Shatz D,<br />
Brundage S, Wall M, et al. Timing of urgent<br />
thoracotomy for hemorrhage after trauma: a<br />
multicenter study. Arch Surg 2001;136:513-518 [LoE<br />
2b]<br />
111. Bowen T, Bellamy R. Emergency war surgery: second<br />
United States revision of the emergency war surgery<br />
NATO handbook: US Department of Defense; 1988.<br />
112. Boyd M, Vanek V, Bourguet C. Emergency room<br />
resuscitative thoracotomy: when is it indicated? J<br />
Trauma 1992;33:714-721 [LoE 1b]<br />
113. Velmahos G, Degiannis E, Souter I, Allwood A,<br />
Saadia R. Outcome of a strict policy on emergency<br />
department thoracotomies. Arch Surg 1995;130:774-<br />
777 [LoE 2b]<br />
114. Branney S, Moore E, Feldhaus K, Wolfe R. Critical<br />
analysis of two decades of experience with postinjury<br />
emergency department thoracotomy in a regional<br />
trauma center. J Trauma 1998;45:87-94 [LoE 2b]<br />
115. Esposito T, Jurkovich G, Rice C, Maier R, Copass M,<br />
Ashbaugh D. Reappraisal of emergency room<br />
thoracotomy in a changing environment. J Trauma<br />
1991;31:881-885 [LoE 2b]<br />
116. Mazzorana V, Smith R, Morabito D, Brar H. Limited<br />
utility of emergency department thoracotomy. Am<br />
Surg 1994;60:516-520 [LoE 2b]<br />
117. Brown S, Gomez G, Jacobson L, Scherer T, McMillan<br />
R. Penetrating chest trauma: should indications for<br />
emergency room thoracotomy be limited? Am Surg<br />
1996;62:530-533 [LoE 2b]<br />
118. Lorenz H, Steinmetz B, Lieberman J, Schecoter W,<br />
Macho J. Emergency thoracotomy: survival correlates<br />
with physiologic status. J Trauma 1992;32:780-785<br />
[LoE 2b]<br />
119. Jahangiri M, Hyde J, Griffin S, Magee P, Youhana A,<br />
Lewis T, et al. Emergency thoracotomy for thoracic<br />
trauma in the accident and emergency department:<br />
indications and outcome. Ann R Coll Surg Engl<br />
1996;78:221-224 [LoE 2b]<br />
120. Grove C, Lemmon G, Anderson G, McCarthy M.<br />
Emergency thoracotomy: appropriate use in the<br />
resuscitation of trauma patients. Am Surg<br />
2002;68:316-317 [LoE 2b]<br />
121. Salim A, Sangthong B, Martin M et al. Whole Body<br />
Imaging in Blunt multisystem trauma patients without<br />
obvious signs of injury. Arch Surg 2006; 141: 468-<br />
475 [LoE 2b]<br />
122. Brink M, Deunk J, Dekker HM et al. Added value of<br />
routine chest mdct after blunt trauma: evaluation of<br />
additional findings and impact on patient<br />
management. AJR 2008; 190: 1591-1598 [LoE 2b]<br />
123. Bruckner BA, Di Bardino DJ, Cumbie TC et al.<br />
Critical evaluation of chest computed tomography<br />
scans for blunt descending thoracic aortic injury. Ann<br />
Thorac Surg 2006; 81: 1339-1347 [LoE 2b]<br />
Emergency room – Abdomen 174
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
124. Ellis JD, Mayo JR. Computed tomography evaluation<br />
of traumatic rupture of the thoracic aorta: an outcome<br />
study. Can J Assoc Radial 2007; 58: 22-26<br />
125. Sammer M, Wang E, Blackmore CC et al.<br />
Indeterminate ct angiography in blunt thoracic trauma:<br />
is ct angiography enough: AJR 2007; 189: 603-608<br />
[LoE 2b]<br />
126. Melton SM, Kerby JD, McGriffin D et al. The<br />
evolution of chest computed tomography for the<br />
definitive diagnosis of blunt aortic injury: a singlecenter<br />
experience. J Trauma 2004; 56: 243-250 [LoE<br />
2b].<br />
127. Soldati G, Testa A, Silva FR et al. Chest<br />
ultrasonography in lung contusion. Chest 2006; 130:<br />
533-538 [LoE 2b]<br />
128. Huber-Wagner S, Lefering R, Quick LM et al. Effect<br />
of whole-body ct during trauma resuscitation on<br />
survival: a retrospective, multicentre study. Lancet<br />
2009; 373: 1455-1461 [LoE 2b]<br />
129. Barrios C, Tran T, Malinoski D et al. Successful<br />
management of occult pneumothorax without tube<br />
thoracostomy despite positive pressure ventilation.<br />
Am Surg 2008; 74: 958-961 [LoE 2b]<br />
130. Wilson H, Ellsmere J, Tallon J, Kirkpatrick A. Occult<br />
pneumothorax in the blunt trauma patient: tube<br />
thoracostomy or observation Injury 2009; June 16<br />
(Epub ahead of print) [LoE 2b]<br />
131. Working Group, Ad Hoc Subcommittee on Outcomes,<br />
American College of Surgeons-Committee on<br />
Trauma. Practice management guidelines for<br />
emergency department thoracotomy. J Am Coll Surg<br />
2001;193:303—9 [Evidenzbasierte Leitlinie]<br />
132. Karmy-Jones R, Nathens A, et al. Urgent and<br />
emergent thoracotomy for penetrating chest trauma. J<br />
T Trauma 2004; 56(3): 664-8<br />
133. Powell, D. W., E. E. Moore, et al. Is emergency<br />
department resuscitative thoracotomy futile care for<br />
the critically injured patient requiring prehospital<br />
cardiopulmonary resuscitation? J Am Coll Surg 2004;<br />
199(2): 211-5.<br />
134. Seamon MJ, Fisher CA et al. Emergency department<br />
thoracotomy: survival of the least expected. World J<br />
Surg 2008; 32(4): 604-12.<br />
135. Fialka C, Sebok C, et al. Open-chest cardiopulmonary<br />
resuscitation after cardiac arrest in cases of blunt chest<br />
or abdominal trauma: a consecutive series of 38 cases.<br />
J Trauma 2004; 57: 809-14.<br />
136. De Moya MA, Seaver C et al. Occult pneumothorax<br />
in trauma patients: development of an objective<br />
scoring system. J Trauma2007; 63: 13-7 [LoE 2b].<br />
Emergency room – Abdomen 175
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.5 Abdomen<br />
Key recommendation:<br />
The abdomen must be examined although a normal finding does not exclude a<br />
relevant intraabdominal injury even in the alert patient.<br />
Explanation:<br />
GoR A<br />
In a prospective study of hemodynamically stable patients after blunt abdominal trauma, Miller<br />
et al. describe how, out of 372 patients examined, an intraabdominal injury could be detected by<br />
CT in only 25.5% of 157 with a painful abdomen or pelvis. The CT detected an injury in only<br />
20% of patients with “seatbelt sign” [24].<br />
Livingston et al. [18] report in a multicenter prospective study of 2,299 patients with blunt<br />
abdominal trauma (exclusion criteria: GCS ≤ 14, children ≤ 16, patients having undergone<br />
emergency laparotomy) that 1,406 (61%) of patients had a positive clinical examination with<br />
regard to external signs of injury or stomach pain. Of these, an abdominal injury could only be<br />
detected by CT in 26 % whilst the clinical examination was recorded as normal in 11% of<br />
patients with an injury detected in the CT. Out of 265 patients with free intraabdominal fluid<br />
detected in the CT, 212 (80%) had an abnormal finding in the clinical examination. In the study,<br />
the sensitivity of the clinical examination for free fluid detected in CT is 85%, specificity 28%,<br />
the positive predictive value 63%, and the negative predictive value 57%.<br />
In a prospective study of 350 patients, Ferrara et al. studied the informative value of abdominal<br />
painfulness for the presence of an intraabdominal injury which had been verified either by CT or<br />
diagnostic peritoneal lavage (DPL) [6]. They calculated a sensitivity of 82%, a specificity of<br />
45%, and a positive predictive value of 21% with a negative predictive value of 93%.<br />
In a prospective study of 162 patients (2001-2003, Level 1 trauma center) after blunt trauma with<br />
a state of clear consciousness (GCS ≥ 14) and normal clinical examination of the abdomen (but<br />
with the necessity of an emergency extraabdominal surgical intervention [88% trauma surgery]<br />
and a CT scan of the abdomen), Gonzalez et al. [7] showed that these patients do not need to<br />
receive any CT diagnostic test prior to the emergency intervention being carried out as the<br />
clinical examination offers sufficient reliability in this patient population. The CT diagnostic<br />
study produced pathologic intraperitoneal findings in only 2 cases (1.2%), which did not require<br />
further intervention (spleen injury, mesenteric hematoma).<br />
Concomitant injuries<br />
In a study of 1,096 patients with blunt abdominal trauma, Grieshop et al. [9] attempted to<br />
discriminate clinical options by which patients who do not require a further diagnostic test such<br />
as CT or DPL could be filtered out. Patients in a state of shock with a GCS value < 11 or who<br />
had suffered spinal trauma were analyzed but due to the limited possibility of clinical<br />
examination were not included in the statistics (n = 140). The authors came to the conclusion that<br />
Emergency room – Abdomen 176
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
besides an abnormal clinical examination (abdominal tenderness, guarding or other signs of<br />
peritonism) the presence of gross hematuria or chest trauma (fractures in ribs 1 or 2, multiple rib<br />
fractures, sternum fracture, scapula fracture, mediastinal widening, hemo- or pneumothorax)<br />
must also be viewed as risk factors. According to them, the risk of an intraabdominal injury with<br />
concomitant chest trauma increases by a factor of 7.6 and in the case of a concomitant gross<br />
hematuria by a factor of 16.4. All patients with relevant intraabdominal injuries (n = 44)<br />
belonged to the group with either an abnormal clinical examination or the presence of either or<br />
both cited risk factors (n = 253) corresponding to a sensitivity of 100%. To exclude an injury to<br />
an organ, the authors further claim that additional diagnostic tests, e.g., performing a computed<br />
tomography scan of the abdomen, must be carried out in such cases. No intraabdominal injuries<br />
were found in the remaining 703 patients who had neither an abnormal clinical examination nor<br />
a risk factor. The calculated negative predictive value was 100% so that further diagnostic tests<br />
could be dispensed with in these cases. A concomitant bony pelvic injury, a closed traumatic<br />
brain injury, spinal injuries, and fractures of the long bones in the lower extremity are not<br />
significant independent risk factors according to this study.<br />
In contrast, Ballard et al. and Mackersie et al. found in prospective studies that pelvic fractures<br />
are also linked to an increased risk of intraabdominal organ injury so that a computed<br />
tomography diagnostic test is thus required for several reasons [2, 20].<br />
Schurink et al. [39] studied the importance of the clinical examination in a retrospective study of<br />
204 patients with further subdivision of the collective into 4 groups: patients with isolated<br />
abdominal trauma (n = 23), patients with lower rib fractures (ribs 7-12) (n = 30), patients with<br />
isolated head injury (n = 56), and multiply injured patients (ISS ≥ 18) (n = 95). All patients<br />
received an abdominal ultrasound examination. With reference to the group with isolated<br />
abdominal trauma, the researchers found in the clinical examination of 20 patients a sensitivity<br />
of 95%, and a negative predictive value of 71% with a positive predictive value of 84% for the<br />
presence of an intraabdominal injury. In the patients with rib fractures, there was a sensitivity<br />
and a negative predictive value of 100% in 4 abnormal clinical findings.<br />
Emergency room – Abdomen 177
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Ultrasonography<br />
Key recommendations:<br />
Initial focused abdominal ultrasonography should be performed to screen for<br />
free fluid, “focused assessment with ultrasonography for trauma” (FAST).<br />
Ultrasound examinations should be repeated at intervals if a computed<br />
tomography scan cannot be performed promptly.<br />
If computed tomography cannot be performed, a focused ultrasonographic<br />
search for parenchymal injuries can represent an alternative to FAST.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
GoR 0<br />
In a systematic review of 4 randomized controlled trials on the value of ultrasound-based<br />
algorithms in diagnosing patients after blunt abdominal trauma, St<strong>eng</strong>el et al. showed that there<br />
is no evidence at present to recommend ultrasound-based algorithms [45]. The same author<br />
carried out an earlier meta-analysis/systematic review on the topic of the diagnostic value of<br />
ultrasonography as the primary test tool for detecting free intraabdominal fluid (FAST) (19<br />
studies) or an intraabdominal organ injury (11 studies) after blunt abdominal trauma. The 30<br />
analyzed studies included studies up to July 2000 with a total of 9,047 patients and evidence<br />
levels from IIb-IIIb [44]. One reported result of the analysis is that abdominal ultrasonography<br />
has only low sensitivity in diagnosing free fluid and intraabdominal organ injuries. It is stated,<br />
for example, that 1 in 10 organ lesions are not identified in primary ultrasonography. For this<br />
reason, ultrasonography is considered inadequate in the primary diagnostic study after abdominal<br />
trauma, and additional diagnostic tests (e.g., helical CT) are recommended both in the case of a<br />
negative and a positive finding [44, 45].<br />
FAST<br />
In a prospective study of 359 hemodynamically stable patients, Miller et al. studied the<br />
importance of FAST under the hypothesis that confidence in the reliability of a FAST<br />
examination leads to intraabdominal injuries after abdominal trauma being missed [24]. As the<br />
gold standard, an abdominal CT scan was performed on all patients within 1 hour of the<br />
ultrasound examination. FAST was carried out in 4 views and positively assessed if there was<br />
evidence of free fluid. The FAST examination yielded 313 true-negative, 16 true-positive, 22<br />
false-negative, and 8 false-positive findings. This led to a sensitivity of 42%, a specificity of<br />
98%, a positive predictive value of 67%, and a negative predictive value of 93%. Of the 22<br />
patients with a false-negative diagnosis, 16 had parenchymal damage of the liver or spleen, one<br />
each had a mesenteric injury and a gallbladder rupture, 2 had a retroperitoneal injury, and 2<br />
further patients had free fluid without any injury detectable by CT. Six patients in this group<br />
required surgery and one underwent vascular embolization by means of angiography. Among the<br />
313 patients with a true-negative FAST finding, a further 19 hepatic and splenic injuries, and 11<br />
retroperitoneal injuries (inter alia hematoma in the aortic wall, bleeding from pancreas head,<br />
Emergency room – Abdomen 178
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
renal contusion) were diagnosed by the CT scan. None of these patients had to undergo surgery.<br />
Consequently, irrespective of the FAST examination finding, the authors call for further<br />
assessment of the adequately hemodynamically stable patient by a CT scan of the abdomen and<br />
pelvis [24].<br />
In a systematic review of studies by McGahan et al. on the importance of FAST in the diagnostic<br />
study after abdominal trauma, the sensitivity of the examination for detecting free fluid ranged<br />
widely from 63 to 100%. McGahan et al. are critical of the fact that, in the studies which gave<br />
high sensitivities and which cited FAST as a suitable initial screening method, significant<br />
weaknesses can be found in the study design (no standard reference, no consecutive inclusion)<br />
[22].<br />
Various other authors also report on organ injuries which could not be diagnosed by FAST and<br />
led to subsequent surgical intervention. In a retrospective study of 2,576 patients, Dolich et al.<br />
found that there were false-negative FAST findings in 1.7% (43 patients) [5]. Ten of these<br />
patients had to undergo a laparotomy as a result. The lack of hemoperitoneum in detected<br />
intraabdominal injuries is described as a limitation of the FAST examination, which is intended<br />
to be used for the primary rapid screening of free fluid. In a retrospective study, it was<br />
demonstrated that 34% of patients (157 out of 467 patients) with an intraabdominal injury had no<br />
hemoperitoneum and thus eluded diagnosis. Twenty-six of these patients had to undergo surgery<br />
[40].<br />
Soyuncu et al. describe a prospective case series with 442 included patients who sustained a<br />
blunt abdominal trauma. They were able to show that a FAST examination carried out by an<br />
operator experienced in abdominal ultrasonography (minimum 1 year’s experience) has a<br />
sensitivity of 86% and a specificity of 99% with 0.95% false-positive and 1.1% false-negative<br />
results (verified by laparotomy, CT, autopsy) [43].<br />
Ultrasonography with organ diagnosis<br />
In a prospective study, Liu et al. [17] compared among 55 hemodynamically stable patients the<br />
diagnostic evidential value of ultrasound (with screening for free fluid and organ lesion),<br />
computed tomography, and DPL each on the same patients. The DPL was carried out after the<br />
imaging procedures so that they did not falsify the diagnosis of free fluid. In the diagnosis of an<br />
intraabdominal injury (without differentiating between the detection of free fluid and the direct<br />
detection of an organ lesion), the authors found a sensitivity of 91.7% and a specificity of 94.7%<br />
for ultrasound, which lay below the results of DPL and CT. The disadvantages of ultrasound are:<br />
(1) the technical difficulty of ultrasound in subcutaneous emphysema, (2) in pre-operated<br />
patients free fluid possibly may not flow into the Douglas space and thus elude diagnosis, (3)<br />
pancreas and hollow organ injuries might not be well assessed and (4) the poor assessability of<br />
the retroperitoneal space. In conclusion, the authors recommended ultrasound because of its<br />
practicability as a primary diagnostic tool in the examination of hemodynamically unstable<br />
patients. However, due to the limitations cited, they warned against overestimating its<br />
informative value.<br />
In a study of 3,264 patients, Richards et al. [34] examined the quality of the abdominal<br />
ultrasound examination in the diagnosis of free fluid and parenchymal organ lesions after<br />
Emergency room – Abdomen 179
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
abdominal trauma. Diverging from the FAST examination, ultrasound was thus used explicitly in<br />
this study to detect parenchymal organ lesions in the liver and spleen or kidneys. The results<br />
were verified by CT, laparotomy, DPL or clinical observation. Free fluid was detected by<br />
ultrasonography in 288 patients and checked by CT and laparotomy. This yielded a sensitivity of<br />
60%, a specificity of 98%, a negative predictive value of 95%, and a positive predictive value of<br />
82% for the diagnosis of free fluid alone. Specific organ lesions were found in 76 cases, 45 with<br />
simultaneously occurring free fluid. The simultaneous focused ultrasound for a parenchymal<br />
organ lesion increased the sensitivity of the diagnosis of an intraabdominal injury to 67%.<br />
Like Richards and Liu et al., Brown et al. [4] examined 2,693 patients after abdominal trauma<br />
for free fluid and also focused for parenchymal injuries. Of these, 172 had an intraabdominal<br />
injury which had been verified by laparotomy, DPL, CT, clinical course or autopsy. In 44<br />
patients (26%) no hemoperitoneum could be detected in the ultrasound but in 19 of these patients<br />
(43%) an organ lesion could be diagnosed in the ultrasound. The authors conclude that organ<br />
injuries are missed by limiting to short ultrasonography focused (FAST) on the diagnosis of free<br />
fluid. As part of the emergency diagnostic study, therefore, an ultrasound examination must be<br />
carried out to look for free fluid and injuries to parenchymal organs.<br />
In a prospective study of 800 patients, higher sensitivities (88%) for the detection of an<br />
intraabdominal injury were found by Healey et al. [10]. This study also included screening for<br />
free fluid and organ lesions, which were compared to CT, DPL, laparotomy, repeated<br />
ultrasonography or clinical course.<br />
In a comparative study design, Poletti et al. [33] also reported higher sensitivities. They<br />
examined 439 patients after abdominal trauma. Of these patients, 222 were not further examined<br />
after the primary normal finding and were discharged with the proviso that they should return if<br />
they thought there was deterioration. Only the remaining 217 patients were analyzed: For the<br />
ultrasonography, a sensitivity of 93% (77 out of 83 patients) was demonstrated for detecting free<br />
fluid and a sensitivity of 41% (39 out of 99 patients) for the direct detection of a parenchymal<br />
organ injury, injuries to the liver being well diagnosed compared to other organ lesions. In a<br />
repeat examination in the case of a primary negative finding, these values could be increased<br />
further but a pathologic finding had previously been found in a CT examination and was also<br />
known to the examiner. A total of 205 patients underwent a follow-up CT examination.<br />
Likewise, in these two studies and in another by Yoshii et al. [52], the high sensitivities for<br />
detecting free fluid are debatable as not all patients received a baseline examination and/or<br />
different baseline examinations (DPL, CT, laparotomy, repeat ultrasonography, clinical<br />
observation) had been used. In addition, patients with primary normal findings were discharged<br />
and did not receive a follow-up examination either [31].<br />
McElveen et al. [21] studied 82 consecutive patients (for free fluid and organ lesion) and verified<br />
all these patients with a baseline examination (71 by CT, 6 by repeat examination, 3 by DPL, and<br />
2 by laparotomy) and a follow-up for a period of 1 week after trauma, either as an inpatient or an<br />
outpatient. With a sensitivity of 88% and a specificity of 98%, accompanied by a negative<br />
predictive value of 97% for the diagnosis of an intraabdominal injury, they recommended the<br />
ultrasound examination as the initial examination method after abdominal trauma.<br />
Emergency room – Abdomen 180
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
In a prospective examination of 210 consecutively included, hemodynamically stable patients<br />
after blunt abdominal trauma, Poletti et al. compared the diagnostic quality of ultrasonography<br />
(with and without intravenous contrast agent) with CT. The patients first received conventional<br />
ultrasonography (including organ diagnostic workup) and then a CT scan. Patients with falsenegative<br />
findings in the primary ultrasonography then received conventional repeat<br />
ultrasonography and, if that yielded a negative finding as well, contrast agent enhanced<br />
ultrasound examination. Poletti et al. [32] showed that neither conventional repeat<br />
ultrasonography nor contrast agent enhanced ultrasonography achieved the quality of computed<br />
tomography in detecting organ injuries. In the computed tomography, 88 organ injuries (solid<br />
organs) were detected in 71 patients. Out of 142 patients in whom no free fluid (intra- or<br />
retroperitoneal) could be detected in the CT, 33 (23%) organ lesions (all organs) were found.<br />
Four of these patients (12%) required an intervention (laparotomy/interventional angiography).<br />
Primary ultrasonography identified 40% (35 out of 88), monitoring ultrasonography 57% (50 out<br />
of 88), and contrast agent enhanced ultrasonography 80% (70 out of 88) of injuries to solid<br />
organs. They concluded that even contrast agent enhanced ultrasonography cannot replace<br />
computed tomography in hemodynamically stable patients.<br />
Repeat examinations<br />
With regard to the importance of repeat sonographic monitoring of the patient after abdominal<br />
trauma, Hoffmann et al. [13] showed that in 19 (18%) of 105 patients with a primary unclear<br />
finding it was only possible to definitely detect free fluid intraabdominally with a repeat<br />
ultrasound examination in the emergency room (after circulation-stabilizing procedures). The<br />
authors pointed out that, if possible, the examination should be carried out by the same examiner<br />
to achieve optimum monitoring. The monitoring examination should be carried out about 10-15<br />
minutes after the primary examination in patients with initially minimal evidence of fluid (1-<br />
2 mm border) or unclear findings. Compared to a DPL, a possible increase in free fluid can by<br />
documented by repeat ultrasonography and the ultrasonography can also be used to diagnose<br />
retroperitoneal and intrathoracic injuries.<br />
In the above-mentioned study, Richards et al. [34] also report an increase in sensitivity of the<br />
ultrasound examination through a repeat examination.<br />
In a prospective study of 156 patients after blunt or penetrating abdominal trauma, Numes et al.<br />
[29] showed that, through repeat ultrasound examinations during the course, false-negative<br />
results for the detection of free intraabdominal fluid could be reduced by 50% and thus the<br />
sensitivity of 69% (with a single scan) was increased to 85%.<br />
Practitioners<br />
With regard to the question as to who must carry out the examination, Hoffmann et al. [13] are<br />
of the opinion that stand-alone screening for free fluid by ultrasound is easily learnt and can then<br />
be reliably carried out by a member of the emergency room team. However, the extent to which<br />
specific questions can be reliably answered depending on the type and l<strong>eng</strong>th of training remains<br />
unclear.<br />
Emergency room – Abdomen 181
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
A prospective study by Ma et al. [19] showed that a 10-hour theory introduction coupled with<br />
carrying out 10-15 examinations on healthy subjects is sufficient to achieve diagnostic certainty<br />
in emergency ultrasonography of the abdomen provided this is restricted to detection/exclusion<br />
of free fluid.<br />
McElveen et al. [21] make the same recommendation although it is not based on a study. They<br />
stipulate 15 examinations on normal patients and 50 monitored examinations on trauma patients.<br />
A retrospective study by Smith et al. [42] on the quality of the ultrasound by trained, experienced<br />
surgeons showed that previous extensive ultrasound experience is not required and there is no<br />
learning curve.<br />
Although also without a comparator study, Brown et al. [4] call for screening for specific organ<br />
lesions to be also included in terms of increasing the sensitivity of the ultrasound examination,<br />
and recommend that this is carried out by an experienced practitioner.<br />
Emergency room – Abdomen 182
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Diagnostic peritoneal lavage (DPL)<br />
Key recommendation:<br />
Diagnostic peritoneal lavage (DPL) must only be used in exceptional cases. GoR A<br />
Explanation:<br />
With a sensitivity of 100% and a specificity of 84.2%, DPL was the most sensitive method for<br />
detecting an intraabdominal injury in the comparative study with CT and ultrasonography by Liu<br />
et al. [17]. As the authors argue, however, the high sensitivity (e.g., by detection of blood from<br />
catheter insertion) leads to a relevant number of non-therapeutic laparotomies. Lui et al. are<br />
critical of DPL also when a retroperitoneal hematoma is present as even small tears in the<br />
peritoneum were reported to yield a positive result, which led to an unnecessary laparotomy in<br />
half of the 6 patients with a retroperitoneal hematoma.<br />
DPL is rapid and, like ultrasonography, can be carried out in parallel with stabilization of the<br />
patient. Its interpretation is not as practitioner-dependent as ultrasonography, it is easy to learn<br />
and can also be repeated. The complication rate is generally given as approximately 1% [8, 23,<br />
47]. Limitations of DPL are its invasiveness and lack of ability to confirm precisely the<br />
underlying injury type and location of the injury and thus the assessment of its clinical relevance.<br />
Using a study of 167 patients with stable circulation with suspected intraabdominal lesion, Mele<br />
et al. showed that, firstly, the number of missed injuries could be reduced by combining a<br />
positive DPL with a subsequent specific examination such as CT compared to a single diagnostic<br />
test by CT and, secondly, as with stand-alone DPL, the number of unnecessary laparotomies<br />
could be reduced [23].<br />
Gonzalez et al. [8] came to the same results in a study of 252 hemodynamically stable patients.<br />
Due to the lower complication rate, with identical diagnostic accuracy, preference should be<br />
given to the open technique over the closed technique for carrying out DPL [12].<br />
Hoffmann [13] sees the indication for DPL only in exceptional cases where patients cannot be<br />
examined with ultrasound (e.g., extreme obesity or abdominal wall emphysema) as DPL permits<br />
no conclusion on retroperitoneal injuries compared to ultrasound and to CT. Waydas cites prior<br />
laparotomies in the lower abdomen in particular as a contraindication of DPL. However, in a<br />
prospective study of 106 multiply injured patients, the authors found a marked lower sensitivity<br />
for ultrasonography (88%) compared to DPL (95%). Despite the lower sensitivity, they<br />
recommended ultrasound as the initial screening method because it is non-invasive, never<br />
contraindicated, and as a diagnostic tool is also able to detect specific organ lesions. In the case<br />
of hemodynamic instability with unclear or negative ultrasound finding, this method can be<br />
supplemented by DPL to increase sensitivity [47].<br />
Indications for primary use of DPL theoretically exist for hemodynamically unstable patients and<br />
if other diagnostic tools (ultrasonography) have failed.<br />
Emergency room – Abdomen 183
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Computed tomography<br />
Key recommendation:<br />
Multi-slice helical CT (MSCT) has a high sensitivity and the highest specificity<br />
for identifying intraabdominal injuries and must therefore be carried out<br />
after abdominal trauma.<br />
Explanation:<br />
GoR A<br />
In the prospective study by Liu et al. [17], the authors compared among 55 hemodynamically<br />
stable patients the diagnostic evidential value of ultrasound (with screening for free fluid and<br />
organ lesion), computed tomography, and DPL each on the same patients. They found a<br />
sensitivity of 97.2% with a specificity of 94.7% for CT. Correspondingly good results are also<br />
separately described in more recent studies [15, 30] for the detection of a hollow organ injury by<br />
computed tomography (after administration of an oral, intravenous contrast agent) but in other<br />
studies this was identified as a diagnostic weak point of CT [41]. In addition, Liu et al. describe<br />
the advantages of computed tomography of the abdomen compared to ultrasonography and DPL<br />
because of the option of reliably imaging the retroperitoneum as well. CT can differentiate well<br />
between hemoperitoneum and fluid retention and can localize fresh bleeding by means of<br />
contrast agent. In addition, computed tomography of the abdomen (through the bone window)<br />
could simultaneously provide a diagnostic study of the spine and the pelvis (or a full-body<br />
helical scan depending on the injury pattern) [28]. Due to the results likewise already reported,<br />
Miller et al. and other authors recommend computed tomography of the abdomen in patients<br />
with stable circulation irrespective of the ultrasound result from a FAST examination as CT<br />
appears, in comparison, to be more sensitive in diagnosing an intraabdominal lesion [24].<br />
With regard to the technicalities of the examination, Linsenmaier recommends a multi-slice<br />
helical CT (MSCT) with regular venous administration of contrast agent for abdominal trauma.<br />
At a pitch of 1.5, the layer thickness should be a minimum of 5-8 mm in the craniocaudal<br />
scanning direction. If there is a suspected injury to the genitourinary system, a delayed scan (3-5<br />
minutes after bolus dose) should be carried out [16]. If it is feasible, an oral contrast agent can<br />
also be administered in principle to improve the diagnosis of intestinal injuries [16, 28].<br />
Novelline describes the administration of Gastrografin via nasogastric tube first in the<br />
emergency room directly after insertion, then shortly before transfer, and lastly in the gantry.<br />
Normally, the stomach, duodenum, and jejunum could be visualized in this way. It is also<br />
possible to contrast the rectum/sigmoid via administration of a contrast agent through a rectal<br />
drain [28].<br />
In a retrospective case-control study of 96 patients (54 consecutively included with<br />
intestinal/mesenteric injury and 42 matched pairs without injury) with laparotomy after<br />
abdominal trauma and with pre-operative CT (standardized with administration of an oral<br />
contrast agent via the nasogastric tube while still in the emergency room), Atri et al. [1] showed<br />
that the multi-slice CT reliably detects relevant injuries in the intestine/mesentery and has a high<br />
negative predictive value. Three radiologists at different stages of training evaluated the CTs<br />
Emergency room – Abdomen 184
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
without knowing the outcome. Thirty-eight (40%) of those examined had surgically relevant<br />
injuries, 58 (60%) had either no or negligible injuries in the intestine or mesentery. Sensitivity<br />
was between 87-95% for the 3 examiners. Only 10 CTs were carried out without oral contrast<br />
agent as the patients were transferred immediately to CT.<br />
In contrast, Stuhlfaut et al. came to the conclusion in a retrospective study of 1,082 patients<br />
(2001-2003) who underwent a multi-slice CT of the abdomen and pelvis without oral contrast<br />
agent that this procedure is sufficient to detect intestinal and mesenteric injuries that require<br />
surgical treatment. Fourteen patients had a suspected intestinal or mesenteric injury after the CT.<br />
Four CTs of these patients showed a pneumoperitoneum, 2 a mesenteric hematoma and intestinal<br />
wall changes, and 4 each showed only a mesenteric hematoma or intestinal wall thickening. In<br />
11 of these patients, an intestinal/mesenteric injury was surgically confirmed. There were 1,066<br />
true-negative, 9 true-positive, 2 false-negative, and 5 false-positive results. Sensitivity was 82%<br />
and specificity 99%. The negative predictive value of the multi-slice helical CT (MSCT)<br />
examination without contrast agent was 99% [46].<br />
In cases of unclarity (only unspecific radiologic findings), Brofman et al. [3] recommend a<br />
clinical re-evaluation and a repeat examination for the possible presence of intestinal/mesenteric<br />
injuries.<br />
The introduction of multi-slice helical CTs is evaluated unanimously by expert opinion as<br />
progress in helical CT technology because, in addition to better resolution, the scanning period<br />
can be considerably shortened and motion artifacts have less effect [16, 28, 33, 35]. The same<br />
authors point out the importance of using pre-programmed protocols for CT diagnosis of recently<br />
injured persons (positioning, layer thickness, table advance, time and type of administration of<br />
contrast agent, bone/soft tissue window, reconstructions) as the examination can thereby be<br />
considerably shortened. In considering the concomitant injuries, some authors recommend the<br />
use of a full-body MSCT after stabilization, if necessary (during which ultrasonography of the<br />
abdomen must be carried out to detect free fluid). Besides the examination of the abdomen, the<br />
full-body MSCT also allows the diagnostic study of head, thorax, skeletal trunk, and the<br />
extremities in one examination round [35].<br />
Computed tomography is the only diagnostic method for which injury scores [25] exist, on the<br />
basis of which treatment decisions can be derived [38].<br />
Carrying out an MSCT can be restricted by the hemodynamic status of the patient (see section<br />
“Influence of the hemodynamic status of the patient on diagnostic study”).<br />
Influence of the hemodynamic status of the patient on the diagnostic study<br />
Key recommendation:<br />
An emergency laparotomy should be introduced without delay in patients who<br />
cannot be hemodynamically stabilized because of an intraabdominal lesion<br />
(free fluid). The possibility of shock of non-abdominal origin should be<br />
considered here.<br />
GoR B<br />
Emergency room – Abdomen 185
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Explanation:<br />
The diagnostic algorithm of a patient with blunt abdominal trauma is fundamentally influenced<br />
by his vital parameters.<br />
The immediate evaluation and stabilization of the vital parameters thus have top priority in the<br />
early phase of treatment. In this section of the early hospital treatment phase, a systolic blood<br />
pressure of > 90 mmHg after infusion of 2,000 ml of crystalloid solution (or > 100 mmHg in<br />
elderly patients) is considered hemodynamically stable with regard to circulatory stability. If,<br />
despite immediate volume replacement and massive transfusion, adequate circulatory function<br />
cannot be restored, Nast-Kolb et al. call for an immediate emergency laparotomy to be<br />
performed in the event of a positive accident anamnesis and existing suspicion of an<br />
intraabdominal injury [27]. It is imperative that, even with unstable vital parameters, the<br />
indication for emergency laparotomy should be supported by ultrasonography of the abdomen in<br />
parallel with polytrauma management. This basic diagnostic work-up is possible without an<br />
additional delay in time [17, 33]. Nast-Kolb’s working group calls for early laparotomy when a<br />
state of shock exists and in multiply injured patients (ISS ≥ 29) even if the detection of fluid is<br />
only small. The authors justify this with the fact that a retrospective, non-therapeutic laparotomy,<br />
compared to the necessary secondary operation in the case of primary missed organ injury,<br />
represents considerably less traumatization and danger [27].<br />
A CT examination of the abdomen should not be carried out until there is adequate circulatory<br />
stability [26, 27, 35, 36, 48] as therapeutic interventions which can sometimes be necessary for<br />
stabilizing the patient are only possible to a limited extent in the CT gantry [27, 35, 36, 48].<br />
According to some authors, this recommendation maintains its validity despite the integration of<br />
the CT in the emergency room (in terms of a priority-oriented use of the emergency room CT<br />
after ABC with basic diagnostic work-up) [14, 49, 50], while Hilbert et al. [11] already discuss<br />
the primary use of CT even in unstable patients.<br />
Emergency room – Abdomen 186
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Atri M, Hanson Jm, Grinblat L et al. (2008) Surgically<br />
important bowel and/or mesenteric injury in blunt<br />
trauma: accuracy of multidetector CT for evaluation.<br />
Radiology 249:524-533 [LoE 3b]<br />
2. Ballard Rb, Rozycki Gs, Newman Pg et al. (1999) An<br />
algorithm to reduce the incidence of false-negative<br />
FAST examinations in patients at high risk for occult<br />
injury. Focused Assessment for the Sonographic<br />
Examination of the Trauma patient. J Am Coll Surg<br />
189:145-150; discussion 150-141 [LoE 2b]<br />
3. Brofman N, Atri M, Hanson Jm et al. (2006)<br />
Evaluation of bowel and mesenteric blunt trauma with<br />
multidetector CT. Radiographics 26:1119-1131 [LoE<br />
5]<br />
4. Brown Ma, Casola G, Sirlin Cb et al. (2001)<br />
Importance of evaluating organ parenchyma during<br />
screening abdominal ultrasonography after blunt<br />
trauma. J Ultrasound Med 20:577-583; quiz 585 [LoE<br />
3b]<br />
5. Dolich Mo, Mckenney Mg, Varela Je et al. (2001)<br />
2,576 ultrasounds for blunt abdominal trauma. J<br />
Trauma 50:108-112 [LoE 4]<br />
6. Ferrera Pc, Verdile Vp, Bartfield Jm et al. (1998)<br />
Injuries distracting from intraabdominal injuries after<br />
blunt trauma. Am J Emerg Med 16:145-149 [LoE 3b]<br />
7. Gonzalez Rp, Han M, Turk B et al. (2004) Screening<br />
for abdominal injury prior to emergent extraabdominal<br />
trauma surgery: a prospective study. J<br />
Trauma 57:739-741 [LoE 4]<br />
8. Gonzalez Rp, Ickler J, Gachassin P (2001)<br />
Complementary roles of diagnostic peritoneal lavage<br />
and computed tomography in the evaluation of blunt<br />
abdominal trauma. J Trauma 51:1128-1134;<br />
discussion 1134-1126 [LoE 1b]<br />
9. Grieshop Na, Jacobson Le, Gomez Ga et al. (1995)<br />
Selective use of computed tomography and diagnostic<br />
peritoneal lavage in blunt abdominal trauma. J<br />
Trauma 38:727-731 [LoE 2b]<br />
10. Healey Ma, Simons Rk, Winchell Rj et al. (1996) A<br />
prospective evaluation of abdominal ultrasound in<br />
blunt trauma: is it useful? J Trauma 40:875-883;<br />
discussion 883-875 [LoE 2b]<br />
11. Hilbert P, Zur Nieden K, Hofmann Go et al. (2007)<br />
New aspects in the emergency room management of<br />
critically injured patients: a multi-slice CT-oriented<br />
care algorithm. Injury 38:552-558 [LoE 4]<br />
12. Hodgson Nf, Stewart Tc, Girotti Mj (2000) Open or<br />
closed diagnostic peritoneal lavage for abdominal<br />
trauma? A meta-analysis. J Trauma 48:1091-1095<br />
[LoE 1a]<br />
13. Hoffmann R, Nerlich M, Muggia-Sullam M et al.<br />
(1992) Blunt abdominal trauma in cases of multiple<br />
trauma evaluated by ultrasonography: a prospective<br />
analysis of 291 patients. J Trauma 32:452-458 [LoE<br />
2b]<br />
14. Kanz Kg, Korner M, Linsenmaier U et al. (2004)<br />
[Priority-oriented shock trauma room management<br />
with the integration of multiple-view spiral computed<br />
tomography]. Unfallchirurg 107:937-944 [LoE 4]<br />
15. Killeen Kl, Shanmuganathan K, Poletti Pa et al.<br />
(2001) Helical computed tomography of bowel and<br />
mesenteric injuries. J Trauma 51:26-36 [LoE 3b]<br />
16. Linsenmaier U, Kanz Kg, Rieger J et al. (2002)<br />
[Structured radiologic diagnosis in polytrauma].<br />
Radiologe 42:533-540 [LoE 4]<br />
17. Liu M, Lee Ch, P'<strong>eng</strong> F K (1993) Prospective<br />
comparison of diagnostic peritoneal lavage, computed<br />
tomographic scanning, and ultrasonography for the<br />
diagnosis of blunt abdominal trauma. J Trauma<br />
35:267-270 [LoE 2b]<br />
18. Livingston Dh, Lavery Rf, Passannante Mr et al.<br />
(2001) Free fluid on abdominal computed tomography<br />
without solid organ injury after blunt abdominal<br />
injury does not mandate celiotomy. Am J Surg 182:6-<br />
9 [LoE 2b]<br />
19. Ma Oj, Kefer Mp, Stevison Kf et al. (2001) Operative<br />
versus nonoperative management of blunt abdominal<br />
trauma: Role of ultrasound-measured intraperitoneal<br />
fluid levels. Am J Emerg Med 19:284-286 [LoE 2b]<br />
20. Mackersie Rc, Tiwary Ad, Shackford Sr et al. (1989)<br />
Intra-abdominal injury following blunt trauma.<br />
Identifying the high-risk patient using objective risk<br />
factors. Arch Surg 124:809-813 [LoE 2b]<br />
21. Mcelveen Ts, Collin Gr (1997) The role of<br />
ultrasonography in blunt abdominal trauma: a<br />
prospective study. Am Surg 63:184-188 [LoE 3b]<br />
22. Mcgahan Jp, Richards J, Gillen M (2002) The focused<br />
abdominal sonography for trauma scan: pearls and<br />
pitfalls. J Ultrasound Med 21:789-800 [LoE 2a]<br />
23. Mele Ts, Stewart K, Marokus B et al. (1999)<br />
Evaluation of a diagnostic protocol using screening<br />
diagnostic peritoneal lavage with selective use of<br />
abdominal computed tomography in blunt abdominal<br />
trauma. J Trauma 46:847-852 [LoE 2b]<br />
24. Miller Mt, Pasquale Md, Bromberg Wj et al. (2003)<br />
Not so FAST. J Trauma 54:52-59; discussion 59-60<br />
[LoE 2b]<br />
25. Moore Ee, Cogbill Th, Jurkovich Gj et al. (1995)<br />
Organ injury scaling: spleen and liver (1994 revision).<br />
J Trauma 38:323-324<br />
26. Nast-Kolb D, Bail Hj, Taeger G (2005) [Current<br />
diagnostics for intra-abdominal trauma]. Chirurg<br />
76:919-926 [LoE 5]<br />
27. Nast-Kolb D, Trupka A, Ruchholtz S et al. (1998)<br />
[Abdominal trauma]. Unfallchirurg 101:82-91 [LoE 5]<br />
28. Novelline Ra, Rhea Jt, Rao Pm et al. (1999) Helical<br />
CT in emergency radiology. Radiology 213:321-339<br />
[LoE 5]<br />
29. Nunes Lw, Simmons S, Hallowell Mj et al. (2001)<br />
Diagnostic performance of trauma US in identifying<br />
abdominal or pelvic free fluid and serious abdominal<br />
or pelvic injury. Acad Radiol 8:128-136 [LoE 3b]<br />
30. Pal Jd, Victorino Gp (2002) Defining the role of<br />
computed tomography in blunt abdominal trauma: use<br />
in the hemodynamically stable patient with a<br />
depressed level of consciousness. Arch Surg<br />
137:1029-1032; discussion 1032-1023 [LoE 3b]<br />
Emergency room – Abdomen 187
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
31. Poletti Pa, Kinkel K, Vermeulen B et al. (2003) Blunt<br />
abdominal trauma: should US be used to detect both<br />
free fluid and organ injuries? Radiology 227:95-103<br />
[LoE 4]<br />
32. Poletti Pa, Platon A, Becker Cd et al. (2004) Blunt<br />
abdominal trauma: does the use of a secondgeneration<br />
sonographic contrast agent help to detect<br />
solid organ injuries? AJR Am J Roentgenol 183:1293-<br />
1301 [LoE 4]<br />
33. Poletti Pa, Wintermark M, Schnyder P et al. (2002)<br />
Traumatic injuries: role of imaging in the<br />
management of the polytrauma victim (conservative<br />
expectation). Eur Radiol 12:969-978 [LoE 4]<br />
34. Richards Jr, Schleper Nh, Woo Bd et al. (2002)<br />
Sonographic assessment of blunt abdominal trauma: a<br />
4-year prospective study. J Clin Ultrasound 30:59-67<br />
[LoE 3b]<br />
35. Rieger M, Sparr H, Esterhammer R et al. (2002)<br />
[Modern CT diagnosis of acute thoracic and<br />
abdominal trauma]. Anaesthesist 51:835-842 [LoE 4]<br />
36. Ruchholtz S, Waydhas C, Schroeder T et al. (2002)<br />
[The value of computed tomography in the early<br />
treatment of seriously injured patients]. Chirurg<br />
73:1005-1012 [LoE 4]<br />
37. Sackett Dl, Richardson Ws, Rosenberg W et al.<br />
(1997) Evidence-based medicine: How to practice and<br />
teach EBM. Churchill Livingstone, London<br />
38. Schueller G (2008) [Evidence-based diagnosis of<br />
abdominal trauma]. Radiologe 48:474-479 [LoE 5]<br />
39. Schurink Gw, Bode Pj, Van Luijt Pa et al. (1997) The<br />
value of physical examination in the diagnosis of<br />
patients with blunt abdominal trauma: a retrospective<br />
study. Injury 28:261-265 [LoE 4]<br />
40. Shanmuganathan K, Mirvis Se, Sherbourne Cd et al.<br />
(1999) Hemoperitoneum as the sole indicator of<br />
abdominal visceral injuries: a potential limitation of<br />
screening abdominal US for trauma. Radiology<br />
212:423-430 [LoE 4]<br />
41. Sherck Jp, Oakes Dd (1990) Intestinal injuries missed<br />
by computed tomography. J Trauma 30:1-5;<br />
discussion 5-7 [LoE 3b]<br />
42. Smith Rs, Kern Sj, Fry Wr et al. (1998) Institutional<br />
learning curve of surgeon-performed trauma<br />
ultrasound. Arch Surg 133:530-535; discussion 535-<br />
536 [LoE 4]<br />
43. Soyuncu S, Cete Y, Bozan H et al. (2007) Accuracy<br />
of physical and ultrasonographic examinations by<br />
emergency physicians for the early diagnosis of<br />
intraabdominal haemorrhage in blunt abdominal<br />
trauma. Injury 38:564-569 [LoE 4]<br />
44. St<strong>eng</strong>el D, Bauwens K, Sehouli J et al. (2001)<br />
Systematic review and meta-analysis of emergency<br />
ultrasonography for blunt abdominal trauma. Br J<br />
Surg 88:901-912 [LoE 2a]<br />
45. St<strong>eng</strong>el D, Bauwens K, Sehouli J et al. (2005)<br />
Emergency ultrasound-based algorithms for<br />
diagnosing blunt abdominal trauma. Cochrane<br />
Database Syst Rev:CD004446 [LoE 1a]<br />
46. Stuhlfaut Jw, Soto Ja, Lucey Bc et al. (2004) Blunt<br />
abdominal trauma: performance of CT without oral<br />
contrast material. Radiology 233:689-694 [LoE 3b]<br />
47. Waydhas C, Nast-Kolb D, Blahs U et al. (1991)<br />
[Abdominal sonography versus peritoneal lavage in<br />
shock site diagnosis in polytrauma]. Chirurg 62:789-<br />
792; discussion 792-783 [LoE 3b]<br />
48. Wintermark M, Poletti Pa, Becker Cd et al. (2002)<br />
Traumatic injuries: organization and ergonomics of<br />
imaging in the emergency environment. Eur Radiol<br />
12:959-968 [LoE 5]<br />
49. Wurmb T, Balling H, Fruhwald P et al. (2009)<br />
[<strong>Polytrauma</strong> management in a period of change: time<br />
analysis of new strategies for emergency room<br />
treatment]. Unfallchirurg 112:390-399<br />
50. Wurmb T, Fruhwald P, Brederlau J et al. (2005) [The<br />
Wurzburg polytrauma algorithm. Concept and first<br />
results of a sliding-gantry-based computer<br />
tomography diagnostic system]. Anaesthesist 54:763-<br />
768; 770-762 [LoE 5]<br />
51. Wurmb Te, Fruhwald P, Hopfner W et al. (2009)<br />
Whole-body multislice computed tomography as the<br />
first line diagnostic tool in patients with multiple<br />
injuries: the focus on time. J Trauma 66:658-665 [LoE<br />
4]<br />
52. Yoshii H, Sato M, Yamamoto S et al. (1998)<br />
Usefulness and limitations of ultrasonography in the<br />
initial evaluation of blunt abdominal trauma. J Trauma<br />
45:45-50; discussion 50-41 [LoE 4]<br />
Emergency room – Abdomen 188
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.6 Traumatic brain injury<br />
Acute management in the emergency room<br />
Once the clinical finding has been checked and the vital functions secured, an imaging diagnostic<br />
study that includes the brain is generally required for multiply injured patients with traumatic<br />
brain injury. As the immediate elimination of intracranial bleeding can be life-saving, there is no<br />
reason for delay if both respiratory and circulatory functions are stable. This requirement also<br />
applies to the responsive injured person at the accident scene who is sedated for intubation and<br />
transport because only a CT examination can differentiate between intracranial bleeding that is<br />
developing and a drug cause for unconsciousness.<br />
Monitoring the clinical finding<br />
Key recommendation:<br />
State of consciousness with pupil function and Glasgow Coma Scale (bilateral<br />
motor function) must be recorded and documented at repeated intervals.<br />
Explanation:<br />
GoR A<br />
In the literature, the only clinical findings with a prognostic informative value are the presence of<br />
wide, fixed pupils [11, 23, 26] and a deterioration in the GCS score [11, 15, 23], both of which<br />
correlate with a poor outcome. There are no prospective randomized controlled trials on using<br />
the clinical findings to guide the treatment. As such studies are definitely not ethically justifiable,<br />
the importance of the clinical examination was upgraded to a Grade of Recommendation A<br />
during the development of the guideline on the assumption, which cannot be confirmed at<br />
present, that the outcome can be improved by the earliest possible detection of life-threatening<br />
conditions with corresponding therapeutic consequences (see the following recommendations).<br />
Despite various difficulties [3], the Glasgow coma scale (GCS) has established itself<br />
internationally as the assessment of the recorded severity at a given point in time of a brain<br />
function impairment. It enables the standardized assessment of the following aspects: eye<br />
opening, verbal response and motor response. The neurologic findings documented with time of<br />
day in the file are vital for the sequence of future treatment. Frequent checks of the neurologic<br />
finding must be carried out to detect any deterioration [11, 13].<br />
However, the use of the GCS on its own carries the risk of a diagnostic gap, particularly if only<br />
cumulative values are considered. This applies to the initial onset of apallic syndrome, which can<br />
become noticeable through spontaneous decerebrate rigidity which is not recorded on the GCS,<br />
and to concomitant injuries to the spinal cord. Motor functions of the extremities must therefore<br />
be recorded with separate lateral differentiation in arm and leg as to whether there is incomplete,<br />
complete or no paralysis. Attention should be paid here to the presence of decorticate or<br />
decerebrate rigidity. Providing no voluntary movements are possible, reaction to painful stimulus<br />
must be recorded on all extremities.<br />
Emergency room – Traumatic brain injury 189
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
If the patient is not unconscious, then orientation, cranial nerve function, coordination, and<br />
speech function must also be recorded.<br />
2.7.3.2 Vital functions<br />
Key recommendations:<br />
The goals are normoxia, normocapnia, and normotension. A fall in arterial<br />
oxygen saturation below 90% must be avoided.<br />
Intubation with adequate ventilation (with capnometry and blood gas<br />
analysis) must be carried out in unconscious patients (reference value GCS<br />
≤ 8).<br />
The goal in adults should be arterial normotension with a systolic blood<br />
pressure not below 90 mmHg.<br />
Explanation:<br />
GoR A<br />
GoR A<br />
GoR B<br />
Prospective randomized controlled trials which study the effect of hypotension and/or hypoxia<br />
on the outcome are certainly indefensible on ethical grounds. However, there are many<br />
retrospective studies [11, 25] which provide evidence of a markedly worse outcome if<br />
hypotension or hypoxia is present. The first priority is to avoid all conditions associated with a<br />
fall in blood pressure or reduction of oxygen saturation in the blood. Due to side effects,<br />
however, aggressive treatment to raise blood pressure and oxygen saturation has not always<br />
proved successful. The goals are normoxia, normocapnia, and normotension.<br />
Intubation is necessary in the case of inadequate spontaneous breathing but definitely also in the<br />
case of unconscious persons with adequate spontaneous breathing. Unfortunately, the literature<br />
does not contain any high quality evidence on this to prove a clear benefit for the intervention.<br />
The main argument in favor of intubation is the efficient prevention of hypoxia. This is a threat<br />
in unconscious persons even with adequate spontaneous breathing as the impaired protective<br />
reflexes can cause aspiration. The main argument against intubation is the hypoxic damage that<br />
can occur through misplaced intubation. In the conditions of the emergency room, however, it<br />
can be assumed that misplaced intubation can be recognized and corrected immediately. After<br />
intubating, it is frequently necessary to ventilate, the effectiveness of which must be monitored<br />
by capnometry and blood gas analyses.<br />
Procedures to secure cardiac circulatory functions are arresting obvious bleeding (provided this<br />
has not already been done), monitoring blood pressure and pulse, and replacing fluid losses, as<br />
described in this guideline. Specific recommendations cannot be made for the infusion solution<br />
to be used in the case of concomitant traumatic brain injury [11].<br />
Emergency room – Traumatic brain injury 190
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Imaging diagnostic tests<br />
Key recommendations:<br />
A CCT scan must be performed in the case of polytrauma with suspected<br />
traumatic brain injury.<br />
A (monitoring) CT scan must be performed in the case of neurologic<br />
deterioration.<br />
A monitoring CCT should be performed within 8 hours on unconscious<br />
patients and/or if there are signs of injury in the initial CCT.<br />
Explanation:<br />
GoR A<br />
GoR A<br />
GoR B<br />
The literature does not disclose any high quality evidence on which situations require cranial<br />
imaging when there is suspected traumatic brain injury. In TBI on its own, the following findings<br />
are associated with an increased risk of intracranial bleeding (absolute indication [16]).<br />
� coma<br />
� clouded consciousness<br />
� amnesia<br />
� other neurologic disorders<br />
� vomiting if there is a close time relationship to the impact of force<br />
� cramp seizure<br />
� clinical signs or roentgenologic evidence of a brain fracture<br />
� suspected impression fracture and/or penetrating injuries<br />
� suspected cerebrospinal fluid fistula<br />
� evidence of a coagulation disorder (third party medical history, “marcumar pass”, nonarresting<br />
bleeding from superficial injuries, etc.)<br />
Emergency room – Traumatic brain injury 191
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Optional indications that require close monitoring as an alternative to imaging comprise:<br />
� unclear information about the accident history<br />
� severe headache<br />
� intoxication through alcohol or drugs<br />
� evidence of high-energy trauma. These are [1] a vehicle speed > 60 km/h, a large<br />
deformation of the vehicle, penetration of > 30 cm into the pass<strong>eng</strong>er cabin, time required to<br />
rescue from vehicle > 20 min, a fall > 6 m, a rollover trauma, a pedestrian or motorbike<br />
collision at > 30 km/h or the rider being thrown from his motorbike.<br />
As a bigger impact force can always be assumed in a multiply injured patient, there was<br />
consensus in the development of the guideline that cranial imaging must be performed in the<br />
event of symptoms of brain damage. If symptoms first occur during the course of treatment or<br />
increase in severity during the course, the imaging must be monitored as intracranial bleeding<br />
can have a delayed onset or can increase in size. The finding of compressive intracranial<br />
bleeding (see Chapter 3.5) requires surgical intervention without delay.<br />
This recommendation is based on the clinical observation that in patients with initially<br />
apparently normal cranial computed tomogram (CCT), intracranial bleeding causing<br />
compression can develop or smaller findings not requiring surgery increase markedly in size and<br />
thus represent a surgery indication. The occurrence of neurologic symptoms can take several<br />
hours and is concealed by the intensive care treatment of unconscious patients. For this reason,<br />
there was agreement that monitoring of CCT should be carried out regularly in these cases.<br />
Computed tomography is the gold standard of cranial imaging because of its generally rapid<br />
availability and easier examination procedure compared to magnetic resonance imaging [28].<br />
Magnetic resonance imaging has a higher sensitivity for localized tissue injuries [10]. For this<br />
reason, it is recommended particularly in patients with neurologic disorders without pathologic<br />
CT finding.<br />
Emergency room – Traumatic brain injury 192
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Cerebral protection treatment<br />
Key recommendation:<br />
Glucocorticoids must not be administered in the treatment of TBI. GoR A<br />
Explanation:<br />
Replacement of failed functions (respiration, nutrient intake [17, 25] etc.) is necessary in braininjured<br />
patients. In the current state of scientific knowledge, the most important goal is to<br />
achieve homeostasis (normoxia, normotension, prevention of hyperthermia) and avert<br />
threatening (e.g., infectious) complications. Sepsis, pneumonia, and blood coagulation disorders<br />
are independent predictors of a poor clinical outcome [18]. The goal of these measures is to limit<br />
the extent of secondary brain damage and to provide those brain cells which have functional<br />
impairment but which have not been destroyed with the best conditions for functional<br />
regeneration. This applies equally if a traumatic brain injury is present in multiple injuries.<br />
Controversy has surrounded the necessity of antibiotic prophylaxis in frontobasal fractures with<br />
liquorrhea. However, there is no evidence for administering antibiotics [5, 27].<br />
Thrombosis prophylaxis by means of physical measures (e.g., compression stockings) is an<br />
undisputed measure for preventing secondary complications. When administering heparin or<br />
heparin derivatives, the benefit must be weighed up against the risk of an increase in the scale of<br />
intracranial bleeding as these drugs are not approved for brain injuries and thus their off-label<br />
use must be approved by the patient or his legal representative.<br />
Antiepileptic treatment prevents the incidence of epileptic seizures in the first week after trauma.<br />
However, the incidence of a seizure in the early phase does not lead to a worse clinical outcome<br />
[22, 25]. Administration of antiepileptics extending over 1-2 weeks is not associated with a<br />
reduction in late traumatic seizures [6, 22, 25].<br />
Up till now, the available data in the scientific literature has been unable to prove the benefit of<br />
other treatment regimens regarded as specifically cerebral-protective. At present, no<br />
recommendation can be given on hyperbaric oxygen treatment [4], therapeutic hypothermia [12,<br />
21], administration of 21-aminosteroids, calcium antagonists, glutamate receptor antagonists or<br />
TRIS buffer [11, 14, 20, 30].<br />
Administering glucocorticoids is no longer indicated due to a significantly increased 14-day case<br />
fatality rate [2, 7] with no improvement in clinical outcome [8].<br />
Emergency room – Traumatic brain injury 193
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Treatment of increased intracranial pressure<br />
Key recommendation:<br />
If severely elevated intracranial pressure is suspected, particularly with signs<br />
of transtentorial herniation (pupil widening, decerebrate rigidity, extensor<br />
reaction to painful stimulus, progressive clouded consciousness), the following<br />
treatments can be given:<br />
� Hyperventilation<br />
� Mannitol<br />
� Hypertonic saline solution<br />
Explanation:<br />
GoR 0<br />
In cases of suspected transtentorial herniation and signs of apallic syndrome (pupil widening,<br />
decerebrate rigidity, extensor reaction to painful stimulus, progressive clouded consciousness),<br />
hyperventilation can be introduced as a treatment option in the early phase after trauma [11, 25].<br />
The guide values are 20 breaths/min in adults. However, hyperventilation, which used to be used<br />
because of its often impressive effect in reducing intracranial pressure, also causes reduced<br />
cerebral perfusion because of the induced vasoconstriction. With aggressive hyperventilation,<br />
this involves the risk of cerebral ischemia and thus deterioration in clinical outcome [25].<br />
The administration of mannitol can lower intracranial pressure [ICP] for a short time (up to 1<br />
hour) [25]. Preference should be given to managing treatment through ICP measurement [29].<br />
Mannitol can also be given without measuring ICP if transtentorial herniation is suspected.<br />
Attention must be paid to serum osmolarity and renal function.<br />
Up till now, there has been a paucity of evidence on the cerebral-protective effect of hypertonic<br />
saline solutions. Mortality appears to be somewhat less compared to mannitol. However, this<br />
conclusion is based on a small number of cases and is statistically not significant [29].<br />
The raised position of the upper body to 30 ° is often recommended although CPP is not affected<br />
by this. However, extremely high ICP values are reduced.<br />
(Analgesic) sedation per se has no ICP reducing effect. However, restless states with abnormal<br />
independent breathing can lead to an increase in ICP but can be favorably influenced. In<br />
addition, improved oxygenation can be achieved through improved breathing. There is<br />
insufficient evidence [19] for the administration of barbiturates, which was recommended in<br />
previous guidelines for intracranial pressure crises not controllable by other means [23]. When<br />
administering barbiturates, attention must be paid to the negative inotropic effect, possible fall in<br />
blood pressure, and impaired neurologic assessment.<br />
Emergency room – Traumatic brain injury 194
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Advanced Trauma Life Support (ATLS ® ) for Doctors.<br />
American College of Surgeons Committee on<br />
Trauma, 7th edn. Chicago/IL, 2004<br />
2. Alderson P, Roberts I. Corticosteroids for acute<br />
traumatic brain injury. The Cochrane Database of<br />
Systematic Reviews 2005, Issue 1. Art. No.:<br />
CD000196.pub2. DOI:<br />
10.1002/14651858.CD000196.pub2<br />
3. Balestreri M, Czosnyka M, Chatfield DA, Steiner LA,<br />
Schmidt EA, Smielewski P, Matta B, Pickard JD:<br />
Predictive value of Glasgow Coma Scale after brain<br />
trauma: change in trend over the past ten years. J<br />
Neurol Neurosurg Psychiatry 75:161-162, 2004.<br />
4. Bennett M, Heard R. Hyperbaric oxygen therapy for<br />
multiple sclerosis. The Cochrane Database of<br />
Systematic Reviews 2004, Issue 1. Art. No.:<br />
CD003057.pub2. DOI:<br />
10.1002/14651858.CD003057.pub2.<br />
5. Brodie HA. Prophylactic antibiotics for posttraumatic<br />
cerebrospinal fluid fistulae. A meta-analysis. Arch<br />
Otolaryngol Head Neck Surg. 123:749-52, 1997.<br />
6. Chang BS, Lowenstein DH. Practice parameter:<br />
Antiepileptic drug prophylaxis in traumatic brain<br />
injury. Neurology 60: 10 – 16, 2003.<br />
7. CRASH trial collaborators. Effect of intravenous<br />
corticosteroids on death within 14 days in 10008<br />
adults with clinically significant head injury (MRC<br />
CRASH trial): randomised placebo-controlled trial.<br />
Lancet 364:1321 – 28, 2004.<br />
8. CRASH trial collaborators. Final results of MRC<br />
CRASH, a randomised placebo-controlled trial of<br />
intravenous corticosteroid in adults with head injury -<br />
outcomes at 6 months. Lancet 365: 1957–59, 2005<br />
[LoE 1b].<br />
9. Firsching R, Messing-Jünger M, Rickels E, Gräber S<br />
und Schwerdtfeger K. Leitlinie Schädelhirntrauma im<br />
Erwachsenenalter der Deutschen Gesellschaft für<br />
Neurochirurgie. AWMF online 2007. http://www.uniduesseldorf.de/AWMF/ll/008-001.htm.<br />
10. Firsching R, Woischneck D, Klein S, Reissberg S,<br />
Döhring W, Peters B. Classification of severe head<br />
injury based on magnetic resonance imaging. Acta<br />
Neurochir (Wien) 143: 263-71, 2001<br />
11. Gabriel EJ, Ghajar J, Jagoda A, Pons PT, Scalea T,<br />
Walters BC; Brain Trauma Foundation. Guidelines for<br />
prehospital management of traumatic brain injury. J<br />
Neurotrauma. 19:111-74, 2002 [Evidenzbasierte<br />
Leitlinie]<br />
12. Harris OA, Colford JM Jr, Good MC, Matz PG. The<br />
role of hypothermia in the management of severe<br />
brain injury: a meta-analysis. Arch Neurol 59:1077-<br />
83, 2002.<br />
13. Karimi A, Burchardi H, Deutsche Interdisziplinäre<br />
Vereinigung für Intensiv- und Notfallmedizin (DIVI)<br />
Stellungnahmen, Empfehlungen zu Problemen der<br />
Intensiv- und Notfallmedizin, 5. Auflage. Köln,<br />
asmuth druck + crossmedia. 2004.<br />
14. Langham J, Goldfrad C, Teasdale G, Shaw D, Rowan<br />
K. Calcium channel blockers for acute traumatic brain<br />
injury (Cochrane Review). In: The Cochrane Library,<br />
Issue 1, 2004. Chichester, UK: John Wiley & Sons,<br />
Ltd.<br />
15. Marmarou A, Lu J, Butcher I, McHugh GS, Murray<br />
GD, Steyerberg EW, Mushkudiani NA, Choi S, Maas<br />
AI. Prognostic value of the Glasgow Coma Scale and<br />
pupil reactivity in traumatic brain injury assessed<br />
pre‐hospital and on enrollment: an IMPACT<br />
analysis. J Neurotrauma. 2007; 24(2):270-80 [LoE<br />
3a].<br />
16. Mendelow AD, Teasdale G, Jennett B, Bryden J,<br />
Hessett C, Murray G. Risks of intracranial haematoma<br />
in head injured adults. Br Med J (Clin Res Ed) 287,<br />
1173-1176, 1983.<br />
17. Perel P, Yanagawa T, Bunn F, Roberts IG, Wentz R.<br />
Nutritional support for head-injured patients.<br />
Cochrane Database of Systematic Reviews 2006,<br />
Issue 4.<br />
18. Piek J, Chesnut RM, Marshall LF, van Berkum-Clark<br />
M, Klauber MR, Blunt BA, Eisenberg HM, Jane JA,<br />
Marmarou A, Foulkes MA. Extracranial<br />
complications of severe head injury. J Neurosurg<br />
77:901-7, 1992<br />
19. Roberts I. Barbiturates for acute traumatic brain injury<br />
(Cochrane Review). In: The Cochrane Library, Issue<br />
1, 2004. Chichester, UK: John Wiley & Sons, Ltd.<br />
20. Roberts I Aminosteroids for acute traumatic brain<br />
injury (Cochrane Review). In: The Cochrane Library,<br />
Issue 1. Chichester, UK: John Wiley & Sons, Ltd.<br />
2004<br />
21. Saxena M, Andrews PJD, Ch<strong>eng</strong> A .Modest cooling<br />
therapies (35ºC to 37.5ºC) for traumatic brain injury.<br />
CochraneDatabase of Systematic Reviews 2008, Issue<br />
3.<br />
22. Schierhout G, Roberts I. Anti-epileptic drugs for<br />
preventing seizures following acute traumatic brain<br />
injury (Cochrane Review). In: The Cochrane Library,<br />
Issue 1, 2004. Chichester, UK: John Wiley & Sons,<br />
Ltd.<br />
23. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care.<br />
Management and Prognosis of Severe Traumatic<br />
Brain Injury. 2000<br />
http://www2.braintrauma.org/guidelines/downloads/bt<br />
f_guidelines_management.pdf [Evidenzbasierte<br />
Leitlinie]<br />
24. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care.<br />
Management and Prognosis of Severe Traumatic<br />
Brain Injury. Update 2003<br />
http://www2.braintrauma.org/guidelines/downloads/bt<br />
f_guidelines_cpp_u1.pdf [Evidenzbasierte Leitlinie]<br />
25. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care. Guidelines<br />
for the Management of Severe Traumatic Brain<br />
Injury. 3 rd Edition.<br />
Emergency room – Traumatic brain injury 195
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
http://braintrauma.org/guidelines/downloads/JON_24<br />
_Supp1.pdf [Evidenzbasierte Leitlinie]<br />
26. Tien HC, Cunha JR, Wu SN, Chughtai T, Tremblay<br />
LN, Brenneman FD, Rizoli SB. Do trauma patients<br />
with a Glasgow Coma Scale score of 3 and bilateral<br />
fixed and dilated pupils have any chance of survival?<br />
J Trauma. 2006;60(2):274-8 [LoE 3b].<br />
27. Villalobos T, Arango C, Kubilis P, Rathore M.<br />
Antibiotic prophylaxis after basilar skull fractures: a<br />
meta-analysis. Clin Infect Dis. 27:364-69, 1998.<br />
28. Vos PE, Alekseenko Y, Battistin L, Birbamer G,<br />
Gerstenbrand F, Potapov A, Prevec T, Stepan Ch A,<br />
Traubner P, Twijnstra A, Vecsei L, von Wild K.<br />
Ch 16 Mild Traumatic Brain Injury. In: Hughes RA,<br />
Brainin M, Gilhus NE, eds. European Handbook of<br />
Neurological Management, 1ed. Blackwell<br />
Publishing, 2006.<br />
29. Wakai A, Roberts IG, Schierhout G. Mannitol for<br />
acute traumatic brain injury. Cochrane Database of<br />
Systematic Reviews 2007, Issue 1. Art. No.:<br />
CD001049. DOI: 10.1002/14651858.CD001049.pub4<br />
[LoE 3b].<br />
30. Willis C, Lybrand S, Bellamy N. Excitatory amino<br />
acid inhibitors for traumatic brain injury (Cochrane<br />
Review). In: The Cochrane Library, Issue 1, 2004.<br />
Chichester, UK: John Wiley & Sons, Ltd.<br />
Emergency room – Traumatic brain injury 196
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.7 Pelvis<br />
What importance does the initial clinical evaluation of the pelvis have?<br />
Key recommendations:<br />
An acute life-threatening pelvic injury must be excluded when the patient is<br />
admitted to the hospital.<br />
GoR A<br />
The stability of the patient’s pelvis must be clinically examined. GoR A<br />
Explanation:<br />
Circulatory unstable polytrauma with external pelvic massive bleeding represents an acute lifethreatening<br />
situation. There is no alternative to immediate surgery to arrest bleeding and to<br />
accelerated blood replacement (expert opinion with strong evidence from medical experience in<br />
general). A life-threatening pelvic injury must therefore be excluded at the earliest opportunity<br />
within the first minutes after arrival in the emergency room [1].<br />
Prerequisites for making the diagnosis are the pelvic examination for stability and external injury<br />
signs and inspection of the abdomen by ultrasonography.<br />
As a rollover trauma is associated with a pelvic fracture in approximately 80% of cases, the<br />
detailed circumstances of the accident event should be ascertained.<br />
The following definitions are commonly used for the most serious type of pelvic fracture with<br />
threatened vitals:<br />
“in extremis” pelvic injury: external pelvic massive bleeding such as, for example, in traumatic<br />
hemipelvectomy or crush injuries after a severe rollover trauma<br />
complex trauma of the pelvis and acetabulum: pelvic and acetabular fractures/<br />
dislocations with additional peripelvic injuries to the cutaneous muscle sheath, the genitourinary<br />
system, the intestine, the great vessels and/or the major neural pathways<br />
complex pelvic trauma, modified according to Pohlemann [43, 45]: similar see above including<br />
pelvic bleeding from torn pelvic veins and venous plexus<br />
traumatic hemipelvectomy: unilateral or bilateral tearing of the bony hemipelvis combined with<br />
the tearing of the major intrapelvic neural and vessel pathways<br />
pelvic-induced circulatory instability (importance of initial blood loss, e.g., > 2,000 ml according<br />
to Bone [6] and > 150 ml/min according to Trunkey [62])<br />
If, based on the clinical assessment, a complex pelvic trauma in terms of an “in extremis”<br />
situation is probable (complex trauma with circulatory instability), the pelvic ring must be closed<br />
immediately, if possible while the patient is still in the emergency room.<br />
Emergency room – Pelvis 197
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The priorities of individual injuries should be weighed up against each other if several injuries<br />
are present. If one or several injuries per se are also life-threatening, only emergency pelvic<br />
stabilization is initially undertaken.<br />
What procedures should be performed during the primary diagnostic study if pelvic<br />
injuries are suspected?<br />
Key recommendation:<br />
During the diagnostic study a pelvic survey radiograph should be taken<br />
and/or computed tomography (CT) be performed.<br />
Explanation:<br />
Clinical examination<br />
GoR A<br />
If the patient does not have acute life-threatening injuries, the physical examination can be<br />
carried out in more detail. It consists of an external inspection and palpation of the pelvic region<br />
ventrally and dorsally. The examination comprises the external search for bruising or<br />
hematomas, checking pelvic stability, and inspection of body orifices with vaginal and rectal<br />
examination. Shlamovitz et al. attest only a low sensitivity of the clinical examination of the<br />
pelvis for detecting a, by definition, mechanically unstable pelvic ring fracture [52]. In a study<br />
from Essen, the sensitivity and specificity of the clinical examination of the pelvis for instability<br />
was 44% and 99%, respectively. However, approximately 1/5 of the unstable pelvic injuries<br />
were first diagnosed using the survey radiograph of the pelvis [38]. In contrast to Kessel et al.<br />
[33] and Their et al. [57], who questioned the necessity of an emergency pelvic survey<br />
radiograph if there is provision for an emergency CT, the pelvic survey should continue to<br />
remain part of the emergency room diagnostic study of polytrauma, according to Pehle [38]. This<br />
also corresponds to the current recommendation of the ATLS ® algorithm. The circulatory<br />
situation must be given priority in decision-making: according to the data from Miller et al. [35],<br />
if blood pressure does not respond to volume replacement, a 30% specificity can be concluded<br />
for relevant intrapelvic bleeding. Conversely, relevant bleeding can be excluded with a high<br />
degree of certainty if blood pressure exceeds 90 mmHg (negative predictive value 100%).<br />
Imaging diagnostic tests:<br />
The radiograph diagnosis should consist of a minimum of an a.p. (anteroposterior) view, which<br />
is then supplemented if necessary by inlet/outlet or oblique views according to Judet. Young et<br />
al. [66] describe that 94% of all pelvic fractures are correctly classified with only an a.p. view of<br />
the pelvis. Edeiken-Monroe [19] found a success rate of 88% for the a.p. view of the pelvis.<br />
Petrisor [41] found that the Judet views usually provide no relevant information.<br />
There are several studies available on the comparison of CT and radiography diagnostic tests<br />
with respect to pelvic fractures: In a retrospective study by Berg [4], 66% of all pelvic fractures<br />
were detected in the a.p. radiograph whereas this rate was 86% in the CT scan with 10-mm axial<br />
slices. The inlet/outlet views also only achieved a success rate of 56%. The study by Harley [30]<br />
Emergency room – Pelvis 198
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
also found a higher sensitivity in the CT scan especially for identifying fractures in the sacrum<br />
and acetabulum. Resnik [46] also described how the plain radiograph misses 9% of fractures but<br />
noted that these missed fractures were not clinically relevant. In contrast, Stewart [55]<br />
recommends that plain radiography should be omitted if computed tomography is already<br />
planned. Kessel et al. [33], Their et al. [57], and Duane et al [18] also question the necessity of<br />
an emergency pelvic survey radiograph if there is provision for an emergency CT.<br />
There is also a series of studies on the different modalities of CT diagnostic tests, which suggest<br />
the conclusion that a 3D reconstruction and particularly the multi-plane reconstruction provide<br />
clear information and simplify the presentation of the extent of the injury.<br />
Naturally, the plain radiograph is of little help in diagnosing bleeding from the pelvic vessels.<br />
Such bleeding can be excluded with high probability only in cases in which no fracture can be<br />
detected in the radiograph. Individual studies have examined to what extent a classification of<br />
fractures can be deduced using conventional diagnostic radiology of vessel lesions. Thus, Dalal<br />
et al [15] found a significantly higher volume requirement particularly in critical anteroposterior<br />
pelvic fractures but which can also be explained by the intraabdominal injuries.<br />
In addition, there are figures on the comparison of CT and angiography in the diagnostic study of<br />
relevant pelvic bleeding: In the study by Pereira [39], an accuracy exceeding 90% was<br />
demonstrated for the dynamic helical CT in identifying pelvic bleeding which required<br />
embolization. Similarly, Miller [35] also reports a sensitivity and specificity of 60% and 92%,<br />
respectively. For Kamaoui, the CT scan of the pelvis with or without contrast agent extravasation<br />
also assists in selecting patients who should undergo angiography [32].<br />
In a study by Brown et al [9], 73% of patients with pelvic fracture and contrast blush in the CT<br />
showed relevant bleeding in the subsequent angiography. Conversely, a source of bleeding was<br />
found in the angiography in almost 70% of patients with a negative CT so that the relevance of<br />
the bleeding must be questioned here. Brasel et al. also describe contrast agent extravasation in<br />
the CT as a marker for the injury severity of pelvic injuries which, however, do not make<br />
angiography compulsory. Similarly to Brown, even though the CT was negative, they found<br />
bleeding in the pelvic region in 33% of cases, which benefit from angiography and embolization<br />
[8].<br />
Blackmore [5] suggested inferring intrapelvic bleeding from contrast agent extravasation in the<br />
CT of 500 ml or more. The analysis of 759 patients produced a highly significant association for<br />
this correlation with a relative risk of 4.8 (95% CI, 3.0-7.8). With an extravasate exceeding<br />
500 ml, bleeding is thus present in almost half of cases. However, provided that less than 200 ml<br />
extravasate is visible, it can be assumed with 95% certainty that there is no bleeding. Sheridan<br />
[51] reports that the bleeding can also be estimated in the plain CT as a correlation exists in the<br />
CT between hematoma formation and bleeding area exceeding 10 cm 3 .<br />
A current study from 2007 [24] studied as an alternative to CT the sensitivity and specificity of<br />
FAST in patients with pelvic fracture as a decision aid between emergency laparotomy and<br />
emergency angiography. The sensitivity and specificity for FAST yielded 26% and 96% but the<br />
emergency ultrasonography with negative result did not assist in deciding between the need for a<br />
laparotomy and angiography in patients with pelvic fracture [24]. A CT scan of the abdomen is<br />
Emergency room – Pelvis 199
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
stipulated for this decision and an ultrasound examination in terms of FAST is not classified as<br />
adequate [8].<br />
Classification of injuries<br />
The injuries of the bony pelvis should be classified using imaging diagnostic tests. A precise<br />
classification of the pelvic fracture forms the basis of prioritized treatment [19]. This<br />
classification should also be undertaken as soon as possible in patients with life-threatening<br />
vitals.<br />
Generally, the classification of the Working Group on Osteosynthesis is used here, which<br />
distinguishes according to Tile between 3 groups:<br />
� stable A injuries with osteoligamentous integrity in the posterior pelvis ring, intact pelvic<br />
floor; the pelvis can resist physiologic forces without dislocation<br />
� rotationally unstable B injuries with partially retained stability in the posterior pelvic ring<br />
� translationally unstable C injuries with disruption in all posterior osteoligamentous<br />
structures and also in the pelvic floor. The dislocation direction (vertical, posterior,<br />
distraction, excess rotation) plays a subordinate role. Thus, the pelvic ring is disrupted<br />
anterior and posterior and the pelvic halves are unstable.<br />
The concept of a complex pelvic fracture applies to all bony injuries of the pelvis with an injury<br />
to the hollow visceral pelvic organs being simultaneously present or injuries to nerves and<br />
vessels or to the efferent urinary tract.<br />
In addition, it is helpful to differentiate between open and closed pelvic injuries. A pelvic injury<br />
is described as open in the following situations:<br />
� primary open pelvic fractures: according to the definition, direct link between bone fracture<br />
and skin or membrane of vagina or of anorectum<br />
� closed pelvic fracture with enclosed tamponades for hemostasis<br />
� closed pelvic lesion with documented contamination of the retroperitoneum due to an<br />
intraabdominal injury [31]<br />
� In contrast, pelvic fractures only with an injury to the bladder or urethra should not be<br />
described as open but instead as complex. Due to the concomitant intraabdominal injuries<br />
with the risk of acute exsanguination and late onset sepsis, open pelvic injuries also have a<br />
high mortality rate of approximately 45% [17].<br />
How is an unstable pelvic fracture detected?<br />
Instability, particularly in the posterior pelvic ring, is accompanied by a strong bleeding tendency<br />
from the presacral venous plexus. Detection of instability should lead to increased attention<br />
being paid to the circulatory situation. Instabilities are described, depending on the rotational<br />
ability of the iliac wing, inwards or outwards, as internal and external rotational instability. In the<br />
Emergency room – Pelvis 200
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
case of translatory instability, this can be present in the horizontal plane as craniocaudal<br />
instability or in the sagittal direction as anteroposterior instability. Besides increased risk of<br />
bleeding, the instability can lead to further complications such as thrombosis and secondary<br />
nerve, vessel and organ injuries. The last-cited injuries can also be primary and have to be<br />
excluded during the primary diagnostic study of unstable pelvic injuries. The pelvic instability<br />
should be managed by early surgery which, depending on the condition of the patient, can only<br />
be done as an emergency procedure initially or can be definitive straightaway, which often takes<br />
more time.<br />
Signs of pelvic instability can be identified in imaging diagnostic tests. These include, for<br />
example, a widening in the symphysis or in the SI joints. A displacement of the iliac wings in a<br />
horizontal or vertical direction should likewise be interpreted as instability. It must always be<br />
borne in mind that the dislocation at the time of the accident is often more drastic than at the time<br />
of the diagnostic study. Thus, the fracture in the transverse process of the 5th lumbar vertebra<br />
should also be classed as a sign of instability if there is simultaneously a pelvic injury but no<br />
displacement of the iliac wing can be detected in the imaging diagnostic study.<br />
The direction of the pelvic instability is important for classification. If there is only rotational<br />
instability of the pelvis around the vertical axis of the posterior pelvic ring, this is a group B<br />
injury. If there is translational instability in the vertical or horizontal direction, this is a group C<br />
injury.<br />
Emergency room – Pelvis 201
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
How is emergency stabilization of the pelvis carried out?<br />
Key recommendation:<br />
Emergency mechanical stabilization should be carried out if the pelvic ring is<br />
unstable and there is hemodynamic instability.<br />
Explanation:<br />
GoR B<br />
Only simple and rapidly applicable procedures are suitable for emergency stabilization of the<br />
pelvis. With regard to the mechanical stability achieved, wrapping a sheet round the pelvis or<br />
using a pneumatic or other type of industrial pelvic girdle is clearly inferior to the ventral<br />
external fixator and the pelvic C-clamp. Nevertheless, both procedures represent an effective<br />
emergency procedure at least temporarily in the emergency situation [16]. On the other hand, the<br />
Ganz pelvic C-clamp or an external fixator differs in the achievable mechanical stability<br />
depending on the fracture type.<br />
Controversy remains around the question of whether to use the ventral external fixator<br />
(supraacetabular) or the pelvic C-clamp. In unstable pelvic injuries of type C according to Tile et<br />
al., preference should be given to the pelvic C-clamp over the external fixator as evidenced by<br />
biomechanical studies [44]. In unstable pelvic injuries of type B, no notable differences could be<br />
found between the external fixator and pelvic C-clamp. There have also been no studies to date<br />
on the question of which method of emergency stabilization has the best effect on arresting<br />
bleeding [10, 14].<br />
Overall, the pelvic C-clamp is used less often than the fixator as it is of a preliminary nature with<br />
regard to pelvic stabilization and is not without risk in its use compared to the external fixator.<br />
Trans-iliac pelvic fractures represent a contraindication because, in the event of dislocation, the<br />
pins can lead to an organ injury in the lesser pelvis. On the other hand, reliable stabilization with<br />
an external fixator is not always possible in dorsal instabilities. Siegmeth et al. [53] hypothesize<br />
that an external fixator is sufficient for instabilities in the anterior pelvic ring but that an injury to<br />
the posterior pelvic ring also requires additional compression in an emergency. As early as the<br />
1980s, Trafton et al. [61] also stipulated the same. The most recent studies on a commercial<br />
emergency pelvic girdle produce contradictory results regarding the reduction in mortality and<br />
the reduction in transfusion of packed red blood cells and the l<strong>eng</strong>th of hospital stay due to the<br />
accident. While Croce [13] found advantages in applying the pelvic girdle studied by him, this<br />
assumption was not confirmed in the results by Ghaemmaghami et al. [25].<br />
Emergency room – Pelvis 202
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
What procedures should be applied in pelvic fractures with regard to concomitant<br />
hemodynamic instability?<br />
Key recommendation:<br />
In the case of persistent bleeding, surgical hemostasis or selective angiography<br />
with subsequent angioembolization should be performed.<br />
Explanation:<br />
GoR B<br />
Depending on the degree of dislocation of the posterior pelvic ring, an unstable pelvis fracture<br />
often leads to a strong bleeding tendency. If an unstable pelvic fracture is diagnosed in<br />
combination with circulatory instability, the pelvic fracture should be considered as the possible<br />
cause of the circulatory instability. Except in the case of severe pelvic rollover trauma,<br />
emergency stabilization of the pelvis can effectuate sustained circulatory stabilization with the<br />
methods already illustrated in combination with the infusion treatment so that the indication for<br />
surgical hemostasis should be re-considered.<br />
If circulatory instability continues despite the previous procedures, further measures should be<br />
taken. There are principally 2 options available: surgical packing and embolization. In selecting<br />
the procedure, it should be considered that only arterial bleeding can be embolized and that it is<br />
estimated that it is the cause of bleeding in severe pelvic injuries in only 10-20% of cases. The<br />
remaining 80% of bleeding is of venous origin [36].<br />
In view of these circumstances, arrest of bleeding through surgically undertaken packing of the<br />
lesser pelvis appears expedient and, at least in the German-speaking world, is considered to be<br />
the first line choice in such a case ([20], prospective study with 20 patients). Likewise in a<br />
prospective study with 150 patients, Cook [11] showed the advantage of rapid mechanical<br />
stabilization and subsequent surgical arrest of bleeding or packing. Pohlemann [43] also came to<br />
similar recommendations based on a prospective study with 19 patients, as did Bosch [7] after a<br />
retrospective analysis of 132 patients.<br />
But embolization can also be considered. Miller [35] values angiography and embolization over<br />
mechanical stabilization. He considers surgical stabilization as simply constituting a delay in<br />
effective hemostasis and moreover as an avoidable surgical trauma for the patient. According to<br />
Hagiwara as well, patients with hypotension and partial responders after 2 l fluid with blunt<br />
abdominal trauma and injuries to the pelvis and/or liver and/or spleen, etc. benefit from<br />
angiography and subsequent embolization. Volume requirement fell significantly after<br />
embolization and the shock index normalized [28, 29].<br />
Agolini [2]states that only a small percentage of patients with pelvic fractures require<br />
embolization. However, if applied, it can then be almost 100% effective. The age of the patient,<br />
the time of embolization, and the extent of the initial circulatory instability influence the survival<br />
rate; e.g., angiography performed 3 hours after the accident showed a mortality of 75%<br />
compared to 14% at less than 3 hours after the accident. In their article from 2004, Pieri et al.<br />
also report 100% effectiveness in emergency angiography with embolization in pelvic-induced<br />
Emergency room – Pelvis 203
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
circulatory instability and bleeding from the obturator artery and the gluteal arteries [42]. In a<br />
more recent study by Tottermann, 2.5% of patients with pelvic injury showed significant arterial<br />
bleeding from the internal iliac artery. With an all-cause mortality of 16% in the patient<br />
population, he found an inverse proportionality between age and survival probability [59].<br />
Panetta [37] postulated early embolization with his own time of 1-5.5 hours (mean: 2.5 hours)<br />
but sees no correlation between the time of the procedure and mortality. No advantages from<br />
embolization were found in outcome reports with a success rate of approximately 50% with a<br />
time of procedure of less than 6 hours after the accident [39]. The group from Kimbrell [34] und<br />
Velmahos [63] confirms the liberal use of embolization in abdominal and pelvic injuries with<br />
detected arterial bleeding even in patients without initial signs of hemodynamic instability.<br />
Gourlay et al. [26] describe angiography as the gold standard in arterial bleeding with pelvic<br />
fractures. A special subpopulation of approximately 7-8% even needed follow-up angiography<br />
due to persistent circulatory instability. In a study by Shapiro [50], indicators for re-angiography<br />
were persistent shock symptoms (BP < 90 mmHg), absence of any other intraabdominal injury,<br />
and persistent base excess of < -10 for more than 6 hours after admission. In the subsequent reangiography,<br />
there was pelvic-induced bleeding in 97% of cases.<br />
In a study by Fangio, approximately 10% of patients with pelvic injury were circulatory<br />
unstable. Subsequent angiography was successful in 96% of cases. Angiography enabled pelvicindependent<br />
bleeding to be diagnosed and treated in 15% of cases. This led to the rate of falsepositive<br />
emergency laparotomies falling in the stated patient population [23]. Sadri et al [47] also<br />
discovered that a specific subgroup of pelvic injuries (approximately 9%) with persistent volume<br />
requirement benefited from emergency mechanical stabilization of the pelvic ring with the pelvic<br />
C-clamp and subsequent angiography/embolization.<br />
On the other hand, Perez [40] basically considers embolization a reliable procedure as well but<br />
sees a need for clarification of the parameters that define the indication and the effectiveness. In<br />
a study by Salim et al., the following parameters were found to have significant predictive values<br />
in identifying the patient population which benefits from angioembolization: SI joint disruption,<br />
female gender, and persistent hypotension [48].<br />
According to Euler [21], interventional-radiologic procedures such as embolization or balloon<br />
catheter occlusion only have importance in the later, post-primary treatment phase and not<br />
during the management of polytrauma. Only 3-5% of patients with unstable circulation with<br />
pelvic injury require or benefit from embolization [3, 22, 36].<br />
As illustrated, there are differing opinions in the literature. To some extent, these differences can<br />
be explained through considerable differences in the patient collectives and their injury severity.<br />
Ultimately, no exclusive recommendation can be given due to the lack of high quality evidence<br />
both for packing and for embolization. Which procedure is given preference in each case<br />
certainly also depends on the local conditions. Besides the availability of embolization, it should<br />
be particularly taken into account that no other procedures can be carried out in parallel on the<br />
patient during this procedure. Finally, reference is made to strict time management, which should<br />
be adhered to in each case.<br />
Emergency room – Pelvis 204
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
It is an interesting fact that 2 studies with favored pelvic packing turn up for the first time in the<br />
North American studies of 2007 which originally emphasized angiography: this corresponds to a<br />
paradigm shift. In his study, Tottermann found a significant BP increase after surgical packing<br />
was carried out. In the subsequent angiography, evidence of arterial bleeding was still<br />
demonstrated in 80% of cases in the patient population studied so that a graduated scheme with<br />
surgical packing and subsequent embolization has been proposed by him [60]. In the study by<br />
Cothren, a significant reduction in packed red blood cells requirement within 24 hours after<br />
hospital admission (approximately 6 versus 12 packed red blood cells (ECs);[12]) was<br />
demonstrated in the pelvic packing-only group compared to the angiography group.<br />
In contrast to this, the latest but not yet published data of the Working Group Pelvis III of the<br />
<strong>DGU</strong> indicate an increase in emergency angiographies carried out in Germany from<br />
approximately 2% to 4%. In 2008, Westhoff recommended the early clinical integration of<br />
interventional emergency embolization for pelvic fractures if the appropriate infrastructure was<br />
available [65].<br />
Verbeek also discussed the necessity of adapting current treatment protocols in the management<br />
of seriously injured patients with pelvic fractures. The goal is to arrest the pelvic-induced<br />
bleeding, and non-therapeutic and false-positive laparotomies in particular must be avoided in<br />
the future [64].<br />
Are there abnormalities present in children and elderly persons with pelvic fractures which<br />
must be noted?<br />
A severe pelvic injury is much more life-threatening to a child and also to the elderly than to a<br />
middle-aged adult, thus requiring even more rapid action. The physiologic compensation options<br />
for circulatory regulation and homeostasis are markedly fewer. The time pressure for decisionmaking<br />
is increased. The chall<strong>eng</strong>e with regard to the child is firstly to identify the threat to vital<br />
function. Circulatory decompensation does not emerge but appears suddenly as the physiology of<br />
the child scarcely offers compensation options. Emergency stabilization of the pelvis can be<br />
carried out through simple, lateral compression on both sides, if necessary using the hands. There<br />
are no large series of pediatric pelvic fractures in the literature. The papers of Torode [58], Silber<br />
[54], and Tarman [56] can be cited, which all report that the treatment guidelines essentially do<br />
not differ from those for adults. There are no reports of the use of a pelvic C-clamp in a child.<br />
The requirements of infusion treatment and surgical arrest of bleeding apply as for adults.<br />
Regarding the imaging diagnostic tests, magnetic resonance imaging has the advantage over<br />
computed tomography in the young growing skeleton in representing structures that are not yet<br />
ossified, thus enabling a multi-planar presentation of a pelvic injury as well. Compared to<br />
computed tomography, plain radiographs have a markedly weaker informative value in<br />
diagnosing bony pelvic structures and, according to Guillamondegui et al. [27], can be<br />
subordinate to CT or completely omitted. As part of screening for injury, the conventional pelvic<br />
survey radiograph is only definitely indicated in patients with unstable circulation, according to<br />
the authors. The elasticity of the pediatric pelvis should be particularly taken into account; it can<br />
lead to a complete restoration of the pelvic skeleton despite severe rollover trauma. In 20% of<br />
pediatric complex pelvic injuries, a normal pelvic skeleton is visualized in the plain radiograph<br />
and in the computed tomography.<br />
Emergency room – Pelvis 205
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Figure 3: Treatment algorithm for complex pelvic trauma [49]<br />
1st decision (3-5 min)<br />
2nd decision (10-15 min)<br />
3rd decision (15-30 min)<br />
Treatment algorithm for complex pelvic trauma:<br />
Initial assessment,<br />
accident history<br />
2<br />
Complex trauma with<br />
unstable circulation? yes<br />
Emergency room – Pelvis 206<br />
no<br />
X-ray or CT of pelvis,<br />
general treatment, if<br />
necessary primary<br />
diagnostic study of other<br />
regions<br />
yes<br />
Evidence of unstable<br />
pelvic fracture?<br />
yes<br />
Unstable circulation?<br />
yes<br />
Massive transfusion,<br />
pelvic C-clamp<br />
Unstable circulation?<br />
yes<br />
Surgery: open reduction,<br />
packing,<br />
pelvic stabilization<br />
Angiography and<br />
embolization<br />
1<br />
4<br />
5<br />
7<br />
10<br />
6<br />
8<br />
12<br />
no<br />
no<br />
no<br />
Surgery:<br />
surgical hemostasis,<br />
packing, pelvic stabilization<br />
Primary diagnostic<br />
study/treatment of other<br />
regions acc. to<br />
polytrauma protocol<br />
no<br />
Unstable circulation?<br />
yes<br />
3<br />
9<br />
11
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Despite the varying and in part quite weak level of evidence, a treatment algorithm can be<br />
derived from the current state of knowledge which can, however, be modified depending on<br />
local logistic conditions.<br />
Emergency room – Pelvis 207
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Adams Je, Davis Gg, Alexander Cb et al. (2003)<br />
Pelvic trauma in rapidly fatal motor vehicle accidents.<br />
J Orthop Trauma 17:406-410 [LoE 4]<br />
2. Agolini Sf, Shah K, Jaffe J et al. (1997) Arterial<br />
embolization is a rapid and effective technique for<br />
controlling pelvic fracture hemorrhage. J Trauma<br />
43:395-399 [LoE 4]<br />
3. Ben-Menachem Y, Coldwell Dm, Young Jw et al.<br />
(1991) Hemorrhage associated with pelvic fractures:<br />
causes, diagnosis, and emergent management. AJR<br />
Am J Roentgenol 157:1005-1014 [LoE 5]<br />
4. Berg Ee, Chebuhar C, Bell Rm (1996) Pelvic trauma<br />
imaging: a blinded comparison of computed<br />
tomography and roentgenograms. J Trauma 41:994-<br />
998 [LoE 2]<br />
5. Blackmore Cc, Jurkovich Gj, Linnau Kf et al. (2003)<br />
Assessment of volume of hemorrhage and outcome<br />
from pelvic fracture. Arch Surg 138:504-508;<br />
discussion 508-509 [LoE 3]<br />
6. Bone L (1992) Emergency treatment of the injured<br />
patient. Saunders, Philadelphia, London, Toronto<br />
[LoE 5]<br />
7. Bosch U, Pohlemann T, Tscherne H (1992) [Primary<br />
management of pelvic injuries]. Orthopade 21:385-<br />
392 [LoE 4]<br />
8. Brasel Kj, Pham K, Yang H et al. (2007) Significance<br />
of contrast extravasation in patients with pelvic<br />
fracture. J Trauma 62:1149-1152 [LoE 4]<br />
9. Brown Cv, Kasotakis G, Wilcox A et al. (2005) Does<br />
pelvic hematoma on admission computed tomography<br />
predict active bleeding at angiography for pelvic<br />
fracture? Am Surg 71:759-762 [LoE 4]<br />
10. Burkhardt M, Culemann U, Seekamp A et al. (2005)<br />
[Strategies for surgical treatment of multiple trauma<br />
including pelvic fracture. Review of the literature].<br />
Unfallchirurg 108:812, 814-820 [LoE 3]<br />
11. Cook Re, Keating Jf, Gillespie I (2002) The role of<br />
angiography in the management of haemorrhage from<br />
major fractures of the pelvis. J Bone Joint Surg Br<br />
84:178-182 [LoE 3]<br />
12. Cothren Cc, Osborn Pm, Moore Ee et al. (2007)<br />
Preperitonal pelvic packing for hemodynamically<br />
unstable pelvic fractures: a paradigm shift. J Trauma<br />
62:834-839; discussion 839-842 [LoE 3]<br />
13. Croce Ma, Magnotti Lj, Savage Sa et al. (2007)<br />
Emergent pelvic fixation in patients with<br />
exsanguinating pelvic fractures. J Am Coll Surg<br />
204:935-939; discussion 940-932 [LoE 4]<br />
14. Culemann U, Tosounidis G, Reilmann H et al. (2003)<br />
[Pelvic fracture. Diagnostics and current treatment<br />
options]. Chirurg 74:687-698; quiz 699-700 [LoE 4]<br />
15. Dalal Sa, Burgess Ar, Siegel Jh et al. (1989) Pelvic<br />
fracture in multiple trauma: classification by<br />
mechanism is key to pattern of organ injury,<br />
resuscitative requirements, and outcome. J Trauma<br />
29:981-1000; discussion 1000-1002 [LoE 4]<br />
16. Deangelis Na, Wixted Jj, Drew J et al. (2008) Use of<br />
the trauma pelvic orthotic device (T-POD) for<br />
provisional stabilisation of anterior-posterior<br />
compression type pelvic fractures: a cadaveric study.<br />
Injury 39:903-906 [LoE 3]<br />
17. Dente Cj, Feliciano Dv, Rozycki Gs et al. (2005) The<br />
outcome of open pelvic fractures in the modern era.<br />
Am J Surg 190:830-835 [LoE 4]<br />
18. Duane Tm, Dechert T, Wolfe Lg et al. (2008) Clinical<br />
examination is superior to plain films to diagnose<br />
pelvic fractures compared to CT. Am Surg 74:476-<br />
479; discussion 479-480 [LoE 3]<br />
19. Edeiken-Monroe Bs, Browner Bd, Jackson H (1989)<br />
The role of standard roentgenograms in the evaluation<br />
of instability of pelvic ring disruption. Clin Orthop<br />
Relat Res:63-76 [LoE 4]<br />
20. Ertel W, Keel M, Eid K et al. (2001) Control of severe<br />
hemorrhage using C-clamp and pelvic packing in<br />
multiply injured patients with pelvic ring disruption. J<br />
Orthop Trauma 15:468-474 [LoE 3]<br />
21. Euler E, Nast-Kolb D, Schweiberer L (1997)<br />
[Acetabular and pelvic fractures in multiple trauma].<br />
Orthopade 26:354-359 [LoE 4]<br />
22. Failinger Ms, Mcganity Pl (1992) Unstable fractures<br />
of the pelvic ring. J Bone Joint Surg Am 74:781-791<br />
[LoE 5]<br />
23. Fangio P, Asehnoune K, Edouard A et al. (2005)<br />
Early embolization and vasopressor administration for<br />
management of life-threatening hemorrhage from<br />
pelvic fracture. J Trauma 58:978-984; discussion 984<br />
[LoE 4]<br />
24. Friese Rs, Malekzadeh S, Shafi S et al. (2007)<br />
Abdominal ultrasound is an unreliable modality for<br />
the detection of hemoperitoneum in patients with<br />
pelvic fracture. J Trauma 63:97-102 [LoE 4]<br />
25. Ghaemmaghami V, Sperry J, Gunst M et al. (2007)<br />
Effects of early use of external pelvic compression on<br />
transfusion requirements and mortality in pelvic<br />
fractures. Am J Surg 194:720-723; discussion 723<br />
[LoE 4]<br />
26. Gourlay D, Hoffer E, Routt M et al. (2005) Pelvic<br />
angiography for recurrent traumatic pelvic arterial<br />
hemorrhage. J Trauma 59:1168-1173; discussion<br />
1173-1164 [LoE 4]<br />
27. Guillamondegui Od, Mahboubi S, Stafford Pw et al.<br />
(2003) The utility of the pelvic radiograph in the<br />
assessment of pediatric pelvic fractures. J Trauma<br />
55:236-239; discussion 239-240 [LoE 4]<br />
28. Hagiwara A, Minakawa K, Fukushima H et al. (2003)<br />
Predictors of death in patients with life-threatening<br />
pelvic hemorrhage after successful transcatheter<br />
arterial embolization. J Trauma 55:696-703 [LoE 4]<br />
29. Hagiwara A, Murata A, Matsuda T et al. (2004) The<br />
usefulness of transcatheter arterial embolization for<br />
patients with blunt polytrauma showing transient<br />
response to fluid resuscitation. J Trauma 57:271-276;<br />
discussion 276-277 [LoE 3]<br />
30. Harley Jd, Mack La, Winquist Ra (1982) CT of<br />
acetabular fractures: comparison with conventional<br />
radiography. AJR Am J Roentgenol 138:413-417<br />
[LoE 3]<br />
Emergency room – Pelvis 208
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
31. Holting T, Buhr Hj, Richter Gm et al. (1992)<br />
Diagnosis and treatment of retroperitoneal hematoma<br />
in multiple trauma patients. Arch Orthop Trauma Surg<br />
111:323-326 [LoE 4]<br />
32. Kamaoui I, Courbiere M, Floccard B et al. (2008)<br />
[Pelvic trauma: impact of iodinated contrast material<br />
extravasation at MDCT on patient management]. J<br />
Radiol 89:1729-1734 [LoE 4]<br />
33. Kessel B, Sevi R, Jeroukhimov I et al. (2007) Is<br />
routine portable pelvic X-ray in stable multiple trauma<br />
patients always justified in a high technology era?<br />
Injury 38:559-563 [LoE 4]<br />
34. Kimbrell Bj, Velmahos Gc, Chan Ls et al. (2004)<br />
Angiographic embolization for pelvic fractures in<br />
older patients. Arch Surg 139:728-732; discussion<br />
732-723 [LoE 4]<br />
35. Miller Pr, Moore Ps, Mansell E et al. (2003) External<br />
fixation or arteriogram in bleeding pelvic fracture:<br />
initial therapy guided by markers of arterial<br />
hemorrhage. J Trauma 54:437-443 [LoE 4]<br />
36. Mucha P, Jr., Welch Tj (1988) Hemorrhage in major<br />
pelvic fractures. Surg Clin North Am 68:757-773<br />
[LoE 4]<br />
37. Panetta T, Sclafani Sj, Goldstein As et al. (1985)<br />
Percutaneous transcatheter embolization for massive<br />
bleeding from pelvic fractures. J Trauma 25:1021-<br />
1029 [LoE 3]<br />
38. Pehle B, Nast-Kolb D, Oberbeck R et al. (2003)<br />
[Significance of physical examination and<br />
radiography of the pelvis during treatment in the<br />
shock emergency room]. Unfallchirurg 106:642-648<br />
[LoE 3]<br />
39. Pereira Sj, O'brien Dp, Luchette Fa et al. (2000)<br />
Dynamic helical computed tomography scan<br />
accurately detects hemorrhage in patients with pelvic<br />
fracture. Surgery 128:678-685 [LoE 4]<br />
40. Perez Jv, Hughes Tm, Bowers K (1998) Angiographic<br />
embolisation in pelvic fracture. Injury 29:187-191<br />
[LoE 4]<br />
41. Petrisor Ba, Bhandari M, Orr Rd et al. (2003)<br />
Improving reliability in the classification of fractures<br />
of the acetabulum. Arch Orthop Trauma Surg<br />
123:228-233 [LoE 2]<br />
42. Pieri S, Agresti P, Morucci M et al. (2004)<br />
[Percutaneous management of hemorrhages in pelvic<br />
fractures]. Radiol Med 107:241-251 [LoE 4]<br />
43. Pohlemann T, Culemann U, Gansslen A et al. (1996)<br />
[Severe pelvic injury with pelvic mass hemorrhage:<br />
determining severity of hemorrhage and clinical<br />
experience with emergency stabilization].<br />
Unfallchirurg 99:734-743 [LoE 2]<br />
44. Pohlemann T, Krettek C, Hoffmann R et al. (1994)<br />
[Biomechanical comparison of various emergency<br />
stabilization measures of the pelvic ring].<br />
Unfallchirurg 97:503-510 [LoE 4]<br />
45. Pohlemann T, Paul C, Gansslen A et al. (1996)<br />
[Traumatic hemipelvectomy. Experiences with 11<br />
cases]. Unfallchirurg 99:304-312 [LoE 3]<br />
46. Resnik Cs, Stackhouse Dj, Shanmuganathan K et al.<br />
(1992) Diagnosis of pelvic fractures in patients with<br />
acute pelvic trauma: efficacy of plain radiographs.<br />
AJR Am J Roentgenol 158:109-112 [LoE 3]<br />
47. Sadri H, Nguyen-Tang T, Stern R et al. (2005)<br />
Control of severe hemorrhage using C-clamp and<br />
arterial embolization in hemodynamically unstable<br />
patients with pelvic ring disruption. Arch Orthop<br />
Trauma Surg 125:443-447 [LoE 4]<br />
48. Salim A, Teixeira Pg, Dubose J et al. (2008)<br />
Predictors of positive angiography in pelvic fractures:<br />
a prospective study. J Am Coll Surg 207:656-662<br />
[LoE 3]<br />
49. Seekamp A, Burkhardt M, Pohlemann T. (2004)<br />
Schockraummanagement bei Verletzungen des<br />
Beckens: Eine systematische Literaturübersicht.<br />
Unfallchirurg 107(10): 903-10<br />
50. Shapiro M, Mcdonald Aa, Knight D et al. (2005) The<br />
role of repeat angiography in the management of<br />
pelvic fractures. J Trauma 58:227-231 [LoE 4]<br />
51. Sheridan Mk, Blackmore Cc, Linnau Kf et al. (2002)<br />
Can CT predict the source of arterial hemorrhage in<br />
patients with pelvic fractures? Emerg Radiol 9:188-<br />
194 [LoE 3]<br />
52. Shlamovitz Gz, Mower Wr, Bergman J et al. (2009)<br />
How (un)useful is the pelvic ring stability<br />
examination in diagnosing mechanically unstable<br />
pelvic fractures in blunt trauma patients? J Trauma<br />
66:815-820 [LoE 3]<br />
53. Siegmeth A, Mullner T, Kukla C et al. (2000)<br />
[Associated injuries in severe pelvic trauma].<br />
Unfallchirurg 103:572-581 [LoE 4]<br />
54. Silber Js, Flynn Jm, Koffler Km et al. (2001) Analysis<br />
of the cause, classification, and associated injuries of<br />
166 consecutive pediatric pelvic fractures. J Pediatr<br />
Orthop 21:446-450 [LoE 4]<br />
55. Stewart Bg, Rhea Jt, Sheridan Rl et al. (2002) Is the<br />
screening portable pelvis film clinically useful in<br />
multiple trauma patients who will be examined by<br />
abdominopelvic CT? Experience with 397 patients.<br />
Emerg Radiol 9:266-271 [LoE 4]<br />
56. Tarman Gj, Kaplan Gw, Lerman Sl et al. (2002)<br />
Lower genitourinary injury and pelvic fractures in<br />
pediatric patients. Urology 59:123-126; discussion<br />
126 [LoE 4]<br />
57. Their Me, Bensch Fv, Koskinen Sk et al. (2005)<br />
Diagnostic value of pelvic radiography in the initial<br />
trauma series in blunt trauma. Eur Radiol 15:1533-<br />
1537 [LoE 4]<br />
58. Torode I, Zieg D (1985) Pelvic fractures in children. J<br />
Pediatr Orthop 5:76-84 [LoE 4]<br />
59. Totterman A, Dormagen Jb, Madsen Je et al. (2006) A<br />
protocol for angiographic embolization in<br />
exsanguinating pelvic trauma: a report on 31 patients.<br />
Acta Orthop 77:462-468 [LoE 3]<br />
60. Totterman A, Madsen Je, Skaga No et al. (2007)<br />
Extraperitoneal pelvic packing: a salvage procedure to<br />
control massive traumatic pelvic hemorrhage. J<br />
Trauma 62:843-852 [LoE 4]<br />
61. Trafton Pg (1990) Pelvic ring injuries. Surg Clin<br />
North Am 70:655-669 [LoE 5]<br />
62. Trunkey Dd (1983) Trauma. Accidental and<br />
intentional injuries account for more years of life lost<br />
in the U.S. than cancer and heart disease. Among the<br />
prescribed remedies are improved preventive efforts,<br />
Emergency room – Pelvis 209
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
speedier surgery and further research. Sci Am 249:28-<br />
35 [LoE 5]<br />
63. Velmahos Gc, Toutouzas Kg, Vassiliu P et al. (2002)<br />
A prospective study on the safety and efficacy of<br />
angiographic embolization for pelvic and visceral<br />
injuries. J Trauma 53:303-308; discussion 308 [LoE<br />
4]<br />
64. Verbeek D, Sugrue M, Balogh Z et al. (2008) Acute<br />
management of hemodynamically unstable pelvic<br />
trauma patients: time for a change? Multicenter<br />
review of recent practice. World J Surg 32:1874-1882<br />
[LoE 3]<br />
65. Westhoff J, Laurer H, Wutzler S et al. (2008)<br />
[Interventional emergency embolization for severe<br />
pelvic ring fractures with arterial bleeding. Integration<br />
into the early clinical treatment algorithm].<br />
Unfallchirurg 111:821-828 [LoE 4]<br />
66. Young Jw, Burgess Ar, Brumback Rj et al. (1986)<br />
Pelvic fractures: value of plain radiography in early<br />
assessment and management. Radiology 160:445-451<br />
[LoE 4]<br />
Emergency room – Pelvis 210
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.8 Genitourinary tract<br />
Primary clinical diagnostic study<br />
Key recommendation:<br />
During the initial exploratory survey, the external urethral meatus and the<br />
transurethral bladder catheter (if the latter is already inserted) should be<br />
examined for blood.<br />
Explanation:<br />
GoR B<br />
Gross hematuria is the cardinal symptom for injuries to the kidney, bladder and/or urethra<br />
whereas in this primary survey ureter injuries are clinically normal in about half of cases [15].<br />
For this reason, the urinary catheter or the meatus should be inspected for blood during the<br />
primary survey of the undressed patient. Blood at the urethral meatus and hematuria must be<br />
differentiated in the clinical examination because they have different diagnostic meanings.<br />
Key recommendation:<br />
The region of flank, abdomen, perineum, and external genitals should be<br />
inspected for hematomas, ecchymoses, and external injuries.<br />
Explanation:<br />
GoR B<br />
As the external physical examination can be carried out rapidly and easily, it should be carried<br />
out in full on all multiply injured patients even if it has only low diagnostic informative value<br />
[16]. The examination includes the search for external injury signs (hematomas, abrasions,<br />
swellings, etc.) in the region of the flanks, perineum, groins, and external genitals. Cotton et al.<br />
and Allen et al. showed that ecchymoses and abrasions in the abdominal region have a close<br />
correlation with the risk of an intraabdominal injury [17, 18]. However, a hematoma on the<br />
penile shaft or a perineal butterfly hematoma indicates an anterior urethral injury.<br />
The value of the digital rectal examination is very critically evaluated in the current literature<br />
[19, 20] as abnormalities are generally found only rarely. In addition to assessing sphincter tone<br />
in the patient with spinal cord injury, the rectal examination should also be carried out if blood<br />
on the meatus or the presence of a relatively severe pelvic fracture indicates a urethral injury.<br />
The finding of a non-palpable, dislocated or hematoma-surrounded prostate represents additional<br />
clinically valuable information which in turn indicates a prostato-membranous tear.<br />
The responsive patient can be questioned about possible details of the accident and pain from an<br />
injury to the genitourinary organs. Abdominal pain can give nonspecific clues to the presence of<br />
intraabdominal lesions [17, 21, 22]. In addition, a bladder rupture is specifically indicated if a<br />
patient experiences the urge to urinate before the trauma but no longer experiences this urge after<br />
Emergency room – Genitourinary tract 211
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
the trauma (without evidence of neurologic lesions) [23] or if the patient tries to urinate without<br />
success [24].<br />
Further information is provided by the circumstances of the accident, the mechanism of injury<br />
[25, 26], and the general condition of the patient [27]. In the injury pattern, particular attention<br />
should be paid to the close relationship between a pelvic fracture and efferent urinary tract<br />
lesions; this will be differentiated below according to organ. From a general view, injuries to the<br />
bladder and/or urethra are present in 6% of all pelvic fractures but on an Abbreviated Injury<br />
Scale (AIS) ≥ 4 injuries are markedly more frequent at 15% than on an AIS ≤ 3 injuries at 5%<br />
[25]. With the same severity of pelvic injury, men have almost double the risk for urologic<br />
injuries due to their anatomy, in particular the urethra [25, 28]. Rib fractures and injuries to<br />
intraabdominal organs increase the probability of injuries being present in the kidneys, ureters,<br />
and bladder [29]. If hypotension cannot be explained by blood losses of other origin, this can<br />
indicate a relatively severe injury to the kidney.<br />
If there is complete urethral rupture, this can cause the transurethral catheter to go off-course [13,<br />
14]. Likewise, an already existing urinary tract injury can be aggravated by the insertion of a<br />
transurethral catheter [30]. Based on these considerations, the patient with clinical signs of a<br />
urethral injury can have a transurethral catheter inserted during the diagnostic examination in the<br />
emergency room in order to better monitor the patient’s urination. Contraindications for<br />
catheterization only exist in very unstable patients for whom catheter insertion would represent<br />
an unnecessary time delay and in unclear conditions even during the diagnostic test (e.g.,<br />
retrograde urethrogram). This also applies to the possibility that transurethral catheterization is<br />
impossible, e.g., due to a complete urethral tear. A more detailed diagnostic work-up follows<br />
below.<br />
Emergency room – Genitourinary tract 212
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
In the case of circulatory instability that does not permit initial continuing<br />
diagnostic tests and if it is impossible to insert a transurethral bladder<br />
catheter, a suprapubic urinary diversion should be performed percutaneously<br />
or by laparotomy (with simultaneous exploration).<br />
Explanation:<br />
GoR B<br />
If circulatory instability is present and if the patient cannot be diagnosed further due to the time<br />
delay and for these reasons a laparotomy should be performed, a suprapubic catheter should be<br />
inserted during this intervention [31] as this can then also be used subsequently for diagnostic<br />
purposes [30]. A rapid urine test and measurement of serum creatinine should be carried out for<br />
laboratory tests.<br />
A rapid urine test (e.g., strip test) of the urine should be carried out to detect hematuria.<br />
Compared to the microscopic examination, the rapid urine test (e.g., strip test) has over 95%<br />
sensitivity and specificity [32-36]. The advantage of the rapid test lies in the results being<br />
available in less than 10 minutes. It is also helpful for the further course of action to have<br />
verification of bacteriuria; this occurs more frequently in elderly patients and can then be<br />
particularly problematic when combined with a urinary tract injury.<br />
Measurement of serum creatinine can assist the ongoing course assessment and the detection of<br />
pre-existing kidney diseases. Hematologic parameters which permit the detection of bleeding,<br />
e.g., from the kidney, are also measured.<br />
Calling on a qualified urologist is considered advisable for all patients with evidence of<br />
genitourinary injuries [37-39], even if this naturally depends on the qualifications of the<br />
physicians involved and the physical and organizational conditions.<br />
Emergency room – Genitourinary tract 213
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The necessity of imaging diagnostic tests<br />
Key recommendation:<br />
All patients with hematuria, blood discharge from the urethral meatus,<br />
dysuria, impossibility of catheterization or any other medical history<br />
information (local hematoma, concomitant injuries, mechanism of injury)<br />
have an increased risk of genitourinary injuries and should be given a focused<br />
diagnostic work-up of the kidney and/or the efferent urinary tract.<br />
Explanation:<br />
GoR B<br />
Even if lesions in the upper and lower urinary tract occur simultaneously in only approximately<br />
0.6% of patients with urologic injuries [40], a complete urological diagnostic study is still<br />
usually carried out in all patients with corresponding indications as this normally records the<br />
complete urinary system in the form of computed tomography with confirmed microscopic or<br />
gross hematuria [41, 42].<br />
Whereas gross hematuria is pathognomonic for genitourinary injuries, microscopic hematuria<br />
represents a borderline situation. In general, however, it is accepted nowadays that microscopic<br />
hematuria should only entail further diagnostic study if other diagnostic injury evidence is<br />
simultaneously present [43-47].<br />
In a large series of 1,588 patients with microscopic hematuria after sharp trauma, only 3 patients<br />
were found with relevant kidney injury [48]. In a similar study of 605 patients with blunt trauma,<br />
none of the patients with only microscopic hematuria had an injury requiring surgery [49]. This<br />
rate was 1 out of 77 in Fallon et al. [50]. Prospective series have confirmed these results [51]. In<br />
a pseudo-randomized study [52], in which the patients received different care depending on the<br />
admission team, Fuhrmann et al. compared 2 different indications for a cystogram: They were<br />
either examined for pelvic fracture, gross or microscopic hematuria (n = 134 patients) or the<br />
examination was limited to patients with gross hematuria only (> 200 erythrocytes per field of<br />
view). All urological injuries in the two groups were correctly identified. Thus, further acute<br />
diagnostic study of the kidneys can be dispensed with in patients who only have microscopic<br />
hematuria without additional injury signs. There are similar results for pediatric trauma and<br />
multiple injuries [53-56].<br />
An important exception is the fact that vertical deceleration trauma in particular contains an<br />
increased risk for kidney injuries [57], which show up as normal in the primary clinical<br />
examination. Biomechanical studies support this argument so that further diagnostic study is<br />
recommended in strong deceleration trauma even without other criteria being present.<br />
Emergency room – Genitourinary tract 214
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
Further imaging diagnostic tests should be carried out on the efferent urinary<br />
tract if one or more of the following criteria apply: hematuria, bleeding from<br />
the urethral meatus or vagina, dysuria, and local hematoma.<br />
Explanation:<br />
GoR B<br />
Numerous studies have shown that bladder ruptures are associated with a pelvic fracture in 80-<br />
90% of cases [24, 25, 58, 59]. This correlation varies slightly depending on what severity grade<br />
the injuries have [11]. Hochberg and Stone [60] found a direct correlation between the number of<br />
fractured pubic rami (1, 2 or 3, 4) and the frequency of bladder ruptures (4%, 12%, 40%). Aihara<br />
et al. [61] also found that the symphysis or the sacroiliac joint had separated in 75% of bladder<br />
ruptures after blunt trauma. Nevertheless, a bladder rupture cannot be deduced from the presence<br />
of a complex pelvic fracture because only 20% (positive predictive value) of patients with<br />
symphysis and sacroiliac joint separation had a bladder rupture.<br />
The close correlation between pelvic fracture and urethral injury is also well documented.<br />
However, the severity grade of injuries again plays a major role [25, 62, 63]. Koraitim et al,<br />
Morgan et al. and Aihara et al. showed consistently that fractures to the pubic rami increase the<br />
risk of a urethral injury, but that this risk rises hugely particularly in more complex pelvic<br />
fractures (type C) [61, 64, 65]. Aihara et al. emphasize that fractures of the lower pubic rami in<br />
particular indicate a urethral injury [61]. Palmer et al. noticed in a series of 200 patients with<br />
pelvic fracture that 26 out of the 27 patients with urologic lesions had a fracture in the anterior<br />
and posterior pelvic ring [66]. This association is less marked in women due to the shorter l<strong>eng</strong>th<br />
and less connective tissue fusing in the female urethra [67]. Urethra injuries in women are<br />
usually accompanied by bleeding vaginal injuries [68-70].<br />
The classic combination of pelvic fracture and gross hematuria allows the conclusion of a<br />
bladder and/or urethral injury to be made with great certainty [71]. Rehm et al. found that of 719<br />
patients with blunt pelvic/abdominal injury all 21 cases with bladder injury were indicated by the<br />
presence of hematuria, which showed up in 17 cases also as gross hematuria [72]. Morey et al.<br />
[71] also reported that all their 85 patients with pelvic fracture had gross hematuria with<br />
simultaneous bladder rupture. In Palmer et al. this rate was in 10 out of 11 patients [66], in Hsieh<br />
et al. in 48 out of 51 [73]. A gap in the symphysis and separation in the sacroiliac joint doubled<br />
the risk for a bladder injury in the study by Aihara et al [61]. But even without a pelvic fracture<br />
being detectable, patients with gross hematuria or blood discharge from the urethral meatus must<br />
be assumed to have an injury to the efferent urinary tract [74].<br />
The difference between hematuria and blood at the urethral meatus can be helpful in<br />
differentiating between bladder and urethral injuries. Thus, Morey et al. describe how all 53<br />
patients with bladder rupture had a hematuria but that the simultaneous presence of blood at the<br />
urethral meatus correctly indicated in all 6 cases a concomitant urethral injury [71].<br />
Emergency room – Genitourinary tract 215
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Studies available internationally show clearly that the absence of hematuria and the simultaneous<br />
exclusion of a pelvic fracture definitely exclude a relevant injury to the bladder or urethra. This<br />
assessment is somewhat more difficult if there is positive evidence of a pelvic fracture. Hochberg<br />
and Stone found that a urologic injury is very unlikely here as well provided the pelvic fracture<br />
does not affect the pubic rami [60].<br />
Imaging diagnostic test of kidneys and ureters<br />
Key recommendations:<br />
Computed tomography with contrast agent should be performed in the case of<br />
suspected kidney injury.<br />
Explanation:<br />
GoR B<br />
The importance of computed tomography (CT) in the primary assessment of blunt abdominal<br />
trauma is not the subject of this text as the diagnostic test focuses on all intraabdominal trauma.<br />
Thus, only the degree of accuracy with which injuries to the kidney and efferent urinary tract can<br />
be detected in the CT will be discussed below. In the literature review, the CT diagnostic test<br />
appears to be the most reliable, comfortable method in assessing blunt abdominal trauma [9, 41,<br />
47, 75-82].<br />
Intravenous pyelography is inferior to CT with respect to diagnostic accuracy [44, 76] yet<br />
represents an important option if CT cannot be performed. This may be the case if the admitting<br />
hospital does not have the necessary equipment available or, more usually, if the patient is<br />
hemodynamically unstable and requires immediate emergency surgery [83]. In such cases, i.v.<br />
pyelography makes it possible to carry out the urologic diagnostic study directly during surgery<br />
[9, 41, 44]. The images are available approximately 10 minutes after administration of the<br />
contrast agent (2 ml/kg). For 284 patients with blunt kidney trauma, Nicolaisen et al. report<br />
perfect sensitivity of i.v. pyelography for identifying blunt injuries and state that in 87% of cases<br />
it was also possible to classify the injury severity grade correctly [29]. Although in 5 cases of 60<br />
patients with normal excretory urography Halsell et al. found smaller renal lesions in the<br />
computed tomography [84], these lesions were clinically less important and could be<br />
conservatively treated.<br />
Various studies report a sensitivity of over 90% in detecting renal injuries by ultrasonography<br />
[85, 86] but the sensitivity is obviously less if the injury has not resulted in free fluid in the<br />
abdomen [85]. This can occur in about 10-20% of cases [87]. Overall, however, ultrasonography<br />
is not sufficiently reliable. On average, intraabdominal lesions will be present in 10-20% of cases<br />
despite negative ultrasonography [87, 88]. Ultrasonography is therefore only suitable as an<br />
additional diagnostic test. However, a randomized study showed that primary ultrasonography<br />
could reduce the necessity of a CT diagnostic test [89] as negative ultrasonography was assessed<br />
as adequately reliable in individual patients without evidence of abdominal injuries.<br />
Angiographic techniques have much more of a therapeutic role than a diagnostic one as<br />
angiography does not really provide any additional diagnostic information compared to CT [77,<br />
Emergency room – Genitourinary tract 216
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
90]. In cases where an injury to the renal artery or its lateral branches can be assumed or active<br />
bleeding is detected by computed tomography, it is expedient to use angiography as preparation<br />
for an embolization [91-95]. In vascular injuries to the renal pedicle (e.g., intimal tear), this<br />
enables the patency of the renal artery to be restored using an endovascular stent. Moreover, in<br />
relatively severe renal injuries with massive bleeding, selective embolization of the bleeding<br />
vessel should be carried out [9, 41, 42] provided the patient has stable circulation. The number of<br />
primary operated patients can be minimized through this radiologic intervention option, which<br />
leads to a reduction in the nephrectomy rate. The success rate of radiologic intervention is about<br />
70-80% [42]. Angiography can also be necessary if CT equipment is not locally available and<br />
the i.v. pyelography does not show the kidney.<br />
In addition to the methods cited, magnetic resonance imaging has been tested by Leppaniemi et<br />
al. [96-98] and it can image some details better than CT [96, 99]. Due to the increased time<br />
involved, however, it is seldom advisable to use this procedure in multiply injured patients<br />
during the acute phase. Magnetic resonance imaging could be beneficial in rare cases if CT is<br />
unavailable or cannot be used because of an allergy to the contrast agent or the CT finding is<br />
unclear.<br />
Detecting a ureter lesion is much more difficult [100-102]. Medina et al. described a sensitivity<br />
of 20% although a very wide range of diagnostic modalities (CT, intravenous pyelography [IVP],<br />
and retrograde pyelogram) was used [15]. In 81 patients with non-iatrogenic blunt ureter injury,<br />
Dobrowolski et al. [103] found i.v. and retrograde pyelography helpful. Ghali et al. [102]<br />
considered only pyelography to be diagnostically reliable even when compared to intraoperative<br />
inspection.<br />
Emergency room – Genitourinary tract 217
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Imaging diagnostic tests of the lower urinary tract<br />
Key recommendation:<br />
If prioritizing permits, retrograde urethrography and a cystogram should be<br />
performed in patients with clinical reference points for a urethral lesion.<br />
If prioritizing permits, a retrograde cystogram should be performed in<br />
patients with clinical reference points for a bladder injury.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
If there is a suspected urethral and/or bladder lesion, retrograde urethrography and a cystogram<br />
should be performed [30]. Retrograde urethrography consists of the transurethral administration<br />
of approximately 400 ml of contrast agent. Provided the urethra is uninjured, urethrography<br />
enables the bladder to be adequately filled with contrast agent. Thereafter, a radiograph is taken,<br />
ideally on 2 planes but often limited for practical reasons to the anteroposterior plane in multiply<br />
injured patients [72]. However, both planes should be represented so that retrovesicular<br />
extravasates are not missed [23]. The cystogram consists of an image after drainage in addition<br />
to the voided image and the filling image as otherwise there will be approximately 10% falsenegative<br />
results [104]. In cases where no retrograde bladder filling can be achieved, the bladder<br />
must be filled via a suprapubic catheter as combined injuries to the bladder and urethra make up<br />
10-20% of all bladder or urethral injuries [61].<br />
In multiply injured patients, due to concomitant injuries, it is not possible in about 20% of cases<br />
to carry out the cystogram within the initial emergency room phase [73]. This may be<br />
unavoidable in individual cases but the diagnostic test must be carried out as soon as possible<br />
thereafter so that no injuries are missed. On the other hand, Hsieh et al. [73] saw no serious<br />
disadvantages in the cases where the diagnosis of a bladder rupture had been delayed until later.<br />
Ultrasound does not play a big role in assessing bladder or urethral injuries but is very helpful in<br />
localizing the bladder for inserting the suprapubic bladder catheter. I.v. pyelography is also<br />
unreliable in assessing uncertain bladder injuries as the bladder resting pressure is too low and<br />
dilutes the contrast agent too much. Several clinical studies have shown that i.v. pyelography<br />
does not detect 64%-84% of bladder injuries [105-108].<br />
Although computed tomography cannot make definite statements on urethral injuries, it is still<br />
very valuable in diagnosing bladder ruptures [109]. However, without separate filling of the<br />
bladder with contrast agent, the CT diagnostic test can only supply indirect evidence. Although<br />
the absence of pelvic fluid collections makes bladder ruptures less likely [110], it can never<br />
definitely exclude a relevant injury. Only the CT cystogram is suitable for this, and it can also be<br />
performed as an alternative to the normal cystogram. In a series of 316 patients, Deck et al.<br />
found evidence of a sensitivity and specificity of 95% and 100%, respectively, for the CT<br />
cystogram in identifying bladder ruptures [111, 112]. Even if these values were somewhat worse<br />
for intraperitoneal ruptures (78% and 99%), the authors still consider that the CT cystogram<br />
Emergency room – Genitourinary tract 218
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
ranks at least equally with the conventional cystogram. Other groups have reported similar<br />
results [113, 114]. For this reason, the CT cystogram can offer time and organizational<br />
advantages particularly in multiply injured patients as the CT diagnostic test is often indicated<br />
here because of other injuries. However, the prerequisite for a definite diagnosis is the sufficient<br />
administration of contrast agent (> 350 ml) to be able to produce and detect an extravasate at all<br />
in the presence of a rupture through sufficient fill pressure [104, 109, 115].<br />
Emergency room – Genitourinary tract 219
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1 Ahmed S, Neel KF. Urethral injury in girls with<br />
fractured pelvis following blunt abdominal trauma. Br<br />
J Urol 1996: 78(3):450-453.<br />
2 Aihara R, Blansfield JS, Millham FH, LaMorte WW,<br />
Hirsch EF. Fracture locations influence the likelihood<br />
of rectal and lower urinary tract injuries in patients<br />
sustaining pelvic fractures. J Trauma 2002:<br />
52(2):205-208.<br />
3 Allen GS, Moore FA, Cox CS, Jr., Wilson JT, Cohn<br />
JM, Duke JH. Hollow visceral injury and blunt<br />
trauma. J Trauma 1998: 45(1):69-75.<br />
4 Altman AL, Haas C, Dinchman KH, Spirnak JP.<br />
Selective nonoperative management of blunt grade 5<br />
renal injury. J Urol 2000: 164(1):27-30.<br />
5 Ambiavagar R, Nambiar R. Traumatic closed avulsion<br />
of the upper ureter. Injury 1979: 11(1):71-76.<br />
6 Anselmo G, Fandella A, Faggiano L, Merlo F,<br />
Maccatrozzo L. Fractures of the penis: therapeutic<br />
approach and long-term results. Br J Urol 1991:<br />
67(5):509-511.<br />
7 Armenakas NA. Current methods of diagnosis and<br />
management of ureteral injuries. World J Urol 1999:<br />
17(2):78-83.<br />
8 Asci R, Sarikaya S, Buyukalpelli R, Saylik A, Yilmaz<br />
AF, Yildiz S. Voiding and sexual dysfunctions after<br />
pelvic fracture urethral injuries treated with either<br />
initial cystostomy and delayed urethroplasty or<br />
immediate primary urethral realignment. Scand J Urol<br />
Nephrol 1999: 33(4):228-233.<br />
9 Batislam E, Ates Y, Germiyanoglu C, Karabulut A,<br />
Gulerkaya B, Erol D. Role of Tile classification in<br />
predicting urethral injuries in pediatric pelvic<br />
fractures. J Trauma 1997: 42(2):285-287 [LoE 5].<br />
10 Baverstock R, Simons R, McLoughlin M. Severe<br />
blunt renal trauma: a 7-year retrospective review from<br />
a provincial trauma centre. Can J Urol 2001:<br />
8(5):1372-1376.<br />
11 Beaujeux R, Saussine C, al-Fakir A, Boudjema K,<br />
Roy C, Jacqmin D et al. Superselective endo-vascular<br />
treatment of renal vascular lesions. J Urol 1995:<br />
153(1):14-17 [LoE 4].<br />
12 Beck D, Marley R, Salvator A, Muakkassa F.<br />
Prospective study of the clinical predictors of a<br />
positive abdominal computed tomography in blunt<br />
trauma patients. J Trauma 2004: 57(2):296-300.<br />
13 Becker CD, Mentha G, Schmidlin F, Terrier F. Blunt<br />
abdominal trauma in adults: role of CT in the<br />
diagnosis and management of visceral injuries. Part 2:<br />
Gastrointestinal tract and retroperitoneal organs. Eur<br />
Radiol 1998: 8(5):772-780 [LoE 5].<br />
14 Black PC, Miller EA, Porter JR, Wessells H. Urethral<br />
and bladder neck injury associated with pelvic<br />
fracture in 25 female patients. J Urol 2006:<br />
175(6):2140-2144 [LoE 5].<br />
15 Bozeman C, Carver B, Zabari G, Caldito G, Venable<br />
D. Selective operative management of major blunt<br />
renal trauma. J Trauma 2004: 57(2):305-309 [LoE 4].<br />
16 Brandes S, Borrelli J, Jr. Pelvic fracture and<br />
associated urologic injuries. World J Surg 2001:<br />
25(12):1578-1587 [LoE 2].<br />
17 Brandes S, Coburn M, Armenakas N, McAninch J.<br />
Diagnosis and management of ureteric injury: an<br />
evidence-based analysis. BJU Int 2004: 94(3):277-289<br />
[LoE 2b].<br />
18 Brandes SB, McAninch JW. Reconstructive surgery<br />
for trauma of the upper urinary tract. Urol Clin North<br />
Am 1999: 26(1):183-99, [LoE 4].<br />
19 Brandes SB, McAninch JW. Urban free falls and<br />
patterns of renal injury: a 20-year experience with 396<br />
cases. J Trauma 1999: 47(4):643-649 [LoE 4].<br />
20 Bretan PN, Jr., McAninch JW, Federle MP, Jeffrey<br />
RB, Jr. Computerized tomographic staging of renal<br />
trauma: 85 consecutive cases. J Urol 1986:<br />
136(3):561-565 [LoE 4].<br />
21 Brosman SA, Paul JG. Trauma of the bladder. Surg<br />
Gynecol Obstet 1976: 143(4):605-608 [LoE 2b].<br />
22 Buchberger W, Penz T, Wicke K, Eberle J. [Diagnosis<br />
and staging of blunt kidney trauma. A comparison of<br />
urinalysis, i.v. urography, sonography and computed<br />
tomography]. Rofo 1993: 158(6):507-512 [LoE 2b].<br />
23 Buckley JC, McAninch JW. Selective management of<br />
isolated and nonisolated grade IV renal injuries. J<br />
Urol 2006: 176(6 Pt 1):2498-2502 [LoE 4].<br />
24 Carroll PR, McAninch JW. Major bladder trauma: the<br />
accuracy of cystography. J Urol 1983: 130(5):887-<br />
888 [LoE 5].<br />
25 Carroll PR, McAninch JW. Major bladder trauma:<br />
mechanisms of injury and a unified method of<br />
diagnosis and repair. J Urol 1984: 132(2):254-257<br />
[LoE 4].<br />
26 Carter CT, Schafer N. Incidence of urethral disruption<br />
in females with traumatic pelvic fractures. Am J<br />
Emerg Med 1993: 11(3):218-220 [LoE 2].<br />
27 Cass AS, Cass BP. Immediate surgical management<br />
of severe renal injuries in multiple-injured patients.<br />
Urology 1983: 21(2):140-145 [LoE 2].<br />
28 Cass AS, Luxenberg M. Features of 164 bladder<br />
ruptures. J Urol 1987: 138(4):743-745 [LoE 4].<br />
29 Cass AS, Vieira J. Comparison of IVP and CT<br />
findings in patients with suspected severe renal injury.<br />
Urology 1987: 29(5):484-487 [LoE 4].<br />
30 Chandhoke PS, McAninch JW. Detection and<br />
significance of microscopic hematuria in patients with<br />
blunt renal trauma. J Urol 1988: 140(1):16-18 [LoE<br />
5].<br />
31 Chapple C, Barbagli G, Jordan G, Mundy AR,<br />
Rodrigues-Netto N, Pansadoro V et al. Consensus<br />
statement on urethral trauma. BJU Int 2004:<br />
93(9):1195-1202 [LoE 4].<br />
32 Chatziioannou A, Brountzos E, Primetis E, Malagari<br />
K, Sofocleous C, Mourikis D et al. Effects of<br />
superselective embolization for renal vascular injuries<br />
on renal parenchyma and function. Eur J Vasc<br />
Endovasc Surg 2004: 28(2):201-206 [LoE 2b].<br />
Emergency room – Genitourinary tract 220
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
33 Ch<strong>eng</strong> DL, Lazan D, Stone N. Conservative treatment<br />
of type III renal trauma. J Trauma 1994: 36(4):491-<br />
494 [LoE 2b].<br />
34 Corr P, Hacking G. Embolization in traumatic<br />
intrarenal vascular injuries. Clin Radiol 1991:<br />
43(4):262-264 [LoE 2b].<br />
35 Corriere JN, Jr., Sandler CM. Management of the<br />
ruptured bladder: seven years of experience with 111<br />
cases. J Trauma 1986: 26(9):830-833 [LoE 2b].<br />
36 Corriere JN, Jr., Sandler CM. Management of<br />
extraperitoneal bladder rupture. Urol Clin North Am<br />
1989: 16(2):275-277 [LoE 2b].<br />
37 Cotton BA, Beckert BW, Smith MK, Burd RS. The<br />
utility of clinical and laboratory data for predicting<br />
intraabdominal injury among children. J Trauma<br />
2004: 56(5):1068-1074 [LoE 4].<br />
38 Culty T, Boccon-Gibod L. Anastomotic urethroplasty<br />
for posttraumatic urethral stricture: previous urethral<br />
manipulation has a negative impact on the <strong>final</strong><br />
outcome. J Urol 2007: 177(4):1374-1377 [LoE 4].<br />
39 Daum GS, Krolikowski FJ, Reuter KL, Colby JM,<br />
Silva WM. Dipstick evaluation of hematuria in<br />
abdominal trauma. Am J Clin Pathol 1988: 89(4):538-<br />
542 [LoE 5].<br />
40 Deck AJ, Shaves S, Talner L, Porter JR.<br />
Computerized tomography cystography for the<br />
diagnosis of traumatic bladder rupture. J Urol 2000:<br />
164(1):43-46 [LoE 4].<br />
41 Deck AJ, Shaves S, Talner L, Porter JR. Current<br />
experience with computed tomographic cystography<br />
and blunt trauma. World J Surg 2001: 25(12):1592-<br />
1596 [LoE 3a].<br />
42 Demetriades D, Karaiskakis M, Toutouzas K, Alo K,<br />
Velmahos G, Chan L. Pelvic fractures: epidemiology<br />
and predictors of associated abdominal injuries and<br />
outcomes. J Am Coll Surg 2002: 195(1):1-10 [LoE 3].<br />
43 Dinkel HP, Danuser H, Triller J. Blunt renal trauma:<br />
minimally invasive management with microcatheter<br />
embolization experience in nine patients. Radiology<br />
2002: 223(3):723-730 [LoE 4].<br />
44 Djakovic N, Plas E, Martinez-Pineiro L, Lynch TH,<br />
Mor Y, Santucci RA et al. Guidelines on urological<br />
trauma. http://uroweb.org/files/uploaded<br />
files/guidelines/urotrauma.pdf: Ezropean Association<br />
of Urology , 1-84. 2009 [Evidenzbasierte Leitlinie]<br />
45 Dobrowolski Z, Kusionowicz J, Drewniak T, Habrat<br />
W, Lipczynski W, Jakubik P et al. Renal and ureteric<br />
trauma: diagnosis and management in Poland. BJU Int<br />
2002: 89(7):748-751 [LoE 4].<br />
46 Dokucu AI, Ozdemir E, Ozturk H, Otcu S, Onen A,<br />
Cigdem K et al. Urogenital injuries in childhood: a<br />
strong association of bladder trauma to bowel injuries.<br />
Int Urol Nephrol 2000: 32(1):3-8 [LoE 4].<br />
47 Eastham JA, Wilson TG, Larsen DW, Ahlering TE.<br />
Angiographic embolization of renal stab wounds. J<br />
Urol 1992: 148(2 Pt 1):268-270 [LoE 3a].<br />
48 El-Sherbiny MT, Aboul-Ghar ME, Hafez AT,<br />
Hammad AA, Bazeed MA. Late renal functional and<br />
morphological evaluation after non-operative<br />
treatment of high-grade renal injuries in children. BJU<br />
Int 2004: 93(7):1053-1056 [LoE 4].<br />
49 Elliott DS, Barrett DM. Long-term followup and<br />
evaluation of primary realignment of posterior<br />
urethral disruptions. J Urol 1997: 157(3):814-816<br />
[LoE 4].<br />
50 Elliott SP, McAninch JW. Ureteral injuries from<br />
external violence: the 25-year experience at San<br />
Francisco General Hospital. J Urol 2003: 170(4 Pt<br />
1):1213-1216 [LoE 4].<br />
51 Fallon B, Wendt JC, Hawtrey CE. Urological injury<br />
and assessment in patients with fractured pelvis. J<br />
Urol 1984: 131(4):712-714 [LoE 4].<br />
52 Fanney DR, Casillas J, Murphy BJ. CT in the<br />
diagnosis of renal trauma. Radiographics 1990:<br />
10(1):29-40 [LoE 2b].<br />
53 Festini G, Gregorutti S, Reina G, Bellis GB. Isolated<br />
intraperitoneal bladder rupture in patients with alcohol<br />
intoxication and minor abdominal trauma. Ann Emerg<br />
Med 1991: 20(12):1371-1372 [LoE 4].<br />
54 Fisher RG, Ben-Menachem Y, Whigham C. Stab<br />
wounds of the renal artery branches: angiographic<br />
diagnosis and treatment by embolization. AJR Am J<br />
Roentgenol 1989: 152(6):1231-1235.<br />
55 Flancbaum L, Morgan AS, Fleisher M, Cox EF. Blunt<br />
bladder trauma: manifestation of severe injury.<br />
Urology 1988: 31(3):220-222.<br />
56 Follis HW, Koch MO, McDougal WS. Immediate<br />
management of prostatomembranous urethral<br />
disruptions. J Urol 1992: 147(5):1259-1262 [LoE 4].<br />
57 Fortune JB, Brahme J, Mulligan M, Wachtel TL.<br />
Emergency intravenous pyelography in the trauma<br />
patient. A reexamination of the indications. Arch Surg<br />
1985: 120(9):1056-1059 [LoE 4].<br />
58 Frohmüller H, Theiß M. Blutungen bei Verletzungen<br />
des Harntrakts. Langenbecks Arch Chir 1993:<br />
110(Suppl):352-357 [LoE 4].<br />
59 Fuhrman GM, Simmons GT, Davidson BS, Buerk<br />
CA. The single indication for cystography in blunt<br />
trauma. Am Surg 1993: 59(6):335-337 [LoE 4].<br />
60 Ghali AM, El Malik EM, Ibrahim AI, Ismail G,<br />
Rashid M. Ureteric injuries: diagnosis, management,<br />
and outcome. J Trauma 1999: 46(1):150-158 [LoE 4].<br />
61 Gheiler EL, Frontera JR. Immediate primary<br />
realignment of prostatomembranous urethral<br />
disruptions using endourologic techniques. Urology<br />
1997: 49(4):596-599 [LoE 2b].<br />
62 Glass RE, Flynn JT, King JB, Blandy JP. Urethral<br />
injury and fractured pelvis. Br J Urol 1978:<br />
50(7):578-582 [LoE 4].<br />
63 Goldin AR, Funston MR. Percutaneous embolization<br />
for post-traumatic renal haemorrhage. S Afr Med J<br />
1978: 53(26):1061-1063 [LoE 4].<br />
64 Goldner AP, Mayron R, Ruiz E. Are urine dipsticks<br />
reliable indicators of hematuria in blunt trauma<br />
patients? Ann Emerg Med 1985: 14(6):580-582 [LoE<br />
2b].<br />
65 Guldner G, Babbitt J, Boulton M, O'Callaghan T,<br />
Feleke R, Hargrove J. Deferral of the rectal<br />
examination in blunt trauma patients: a clinical<br />
decision rule. Acad Emerg Med 2004: 11(6):635-641<br />
[LoE 2b].<br />
Emergency room – Genitourinary tract 221
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
66 Hagiwara A, Murata A, Matsuda T, Matsuda H,<br />
Shimazaki S. The usefulness of transcatheter arterial<br />
embolization for patients with blunt polytrauma<br />
showing transient response to fluid resuscitation. J<br />
Trauma 2004: 57(2):271-276 [LoE 4].<br />
67 Halsell RD, Vines FS, Shatney CH, Slepin MJ,<br />
Northup HM, Avara WT, III et al. The reliability of<br />
excretory urography as a screening examination for<br />
blunt renal trauma. Ann Emerg Med 1987:<br />
16(11):1236-1239 [LoE 4].<br />
68 Hammer CC, Santucci RA. Effect of an institutional<br />
policy of nonoperative treatment of grades I to IV<br />
renal injuries. J Urol 2003: 169(5):1751-1753 [LoE<br />
4].<br />
69 Herschorn S, Thijssen A, Radomski SB. The value of<br />
immediate or early catheterization of the traumatized<br />
posterior urethra. J Urol 1992: 148(5):1428-1431<br />
[LoE 4].<br />
70 Heyns CF, van VP. Increasing role of angiography<br />
and segmental artery embolization in the management<br />
of renal stab wounds. J Urol 1992: 147(5):1231-1234<br />
[LoE 4].<br />
71 Hochberg E, Stone NN. Bladder rupture associated<br />
with pelvic fracture due to blunt trauma. Urology<br />
1993: 41(6):531-533 [LoE 4].<br />
72 Holevar MEJLFNKSRSJPYC. Practice management<br />
guidelines for the management of genitourinary<br />
trauma. http://www.east.org/tpg.html: Eastern<br />
Association for the Surgery of Trauma (EAST) , 1-<br />
101. 2004 [Evidenzbasierte Leitlinie]<br />
73 Holmes JF, Sokolove PE, Brant WE, Palchak MJ,<br />
Vance CW, Owings JT et al. Identification of children<br />
with intra-abdominal injuries after blunt trauma. Ann<br />
Emerg Med 2002: 39(5):500-509 [LoE 4].<br />
74 Horstman WG, McClennan BL, Heiken JP.<br />
Comparison of computed tomography and<br />
conventional cystography for detection of traumatic<br />
bladder rupture. Urol Radiol 1991: 12(4):188-193<br />
[LoE 4].<br />
75 Hsieh CH, Chen RJ, Fang JF, Lin BC, Hsu YP, Kao<br />
JL et al. Diagnosis and management of bladder injury<br />
by trauma surgeons. Am J Surg 2002: 184(2):143-147<br />
[LoE 3].<br />
76 Husmann DA, Gilling PJ, Perry MO, Morris JS,<br />
Boone TB. Major renal lacerations with a devitalized<br />
fragment following blunt abdominal trauma: a<br />
comparison between nonoperative (expectant) versus<br />
surgical management. J Urol 1993: 150(6):1774-1777<br />
[LoE 3].<br />
77 Husmann DA, Morris JS. Attempted nonoperative<br />
management of blunt renal lacerations extending<br />
through the corticomedullary junction: the short-term<br />
and long-term sequelae. J Urol 1990: 143(4):682-684<br />
[LoE 4].<br />
78 Husmann DA, Wilson WT, Boone TB, Allen TD.<br />
Prostatomembranous urethral disruptions:<br />
management by suprapubic cystostomy and delayed<br />
urethroplasty. J Urol 1990: 144(1):76-78 [LoE 4].<br />
79 Ichigi Y, Takaki N, Nakamura K, Sato S, Kato A,<br />
Matsuo Y et al. Significance of hematoma size for<br />
evaluating the grade of blunt renal trauma. Int J Urol<br />
1999: 6(10):502-508 [LoE 4].<br />
80 Ingram MD, Watson SG, Skippage PL, Patel U.<br />
Urethral injuries after pelvic trauma: evaluation with<br />
urethrography. Radiographics 2008: 28(6):1631-1643<br />
[LoE 5].<br />
81 Iverson AJ, Morey AF. Radiographic evaluation of<br />
suspected bladder rupture following blunt trauma:<br />
critical review. World J Surg 2001: 25(12):1588-1591<br />
[LoE 5].<br />
82 Keller MSCCEGJJSKHGMCWTR. Functional<br />
outcome of nonoperatively managed renal injuries in<br />
children. J Trauma 2004: 57:108-110 [LoE 5].<br />
83 Kennedy TJ, McConnell JD, Thal ER. Urine dipstick<br />
vs. microscopic urinalysis in the evaluation of<br />
abdominal trauma. J Trauma 1988: 28(5):615-617<br />
[LoE 4].<br />
84 Kinnunen J, Kivioja A, Poussa K, Laasonen EM.<br />
Emergency CT in blunt abdominal trauma of multiple<br />
injury patients. Acta Radiol 1994: 35(4):319-322 [LoE<br />
4].<br />
85 Klein S, Johs S, Fujitani R, State D. Hematuria<br />
following blunt abdominal trauma. The utility of<br />
intravenous pyelography. Arch Surg 1988:<br />
123(9):1173-1177 [LoE 5].<br />
86 Knudson MM, McAninch JW, Gomez R, Lee P,<br />
Stubbs HA. Hematuria as a predictor of abdominal<br />
injury after blunt trauma. Am J Surg 1992:<br />
164(5):482-485 [LoE 5].<br />
87 Koraitim MM. Pelvic fracture urethral injuries:<br />
evaluation of various methods of management. J Urol<br />
1996: 156(4):1288-1291 [LoE 4].<br />
88 Koraitim MM. Pelvic fracture urethral injuries: the<br />
unresolved controversy. J Urol 1999: 161(5):1433-<br />
1441 [LoE 2a].<br />
89 Koraitim MM, Marzouk ME, Atta MA, Orabi SS.<br />
Risk factors and mechanism of urethral injury in<br />
pelvic fractures. Br J Urol 1996: 77(6):876-880 [LoE<br />
1b].<br />
90 Kotkin L, Koch MO. Impotence and incontinence<br />
after immediate realignment of posterior urethral<br />
trauma: result of injury or management? J Urol 1996:<br />
155(5):1600-1603 [LoE 4].<br />
91 Ku JH, Jeon YS, Kim ME, Lee NK, Park YH. Is there<br />
a role for magnetic resonance imaging in renal<br />
trauma? Int J Urol 2001: 8(6):261-267 [LoE 4].<br />
92 Ku JH, Jeon YS, Kim ME, Lee NK, Park YH.<br />
Comparison of long-term results according to the<br />
primary mode of management and type of injury for<br />
posterior urethral injuries. Urol Int 2002: 69(3):227-<br />
232 [LoE 4].<br />
93 Leppaniemi A, Lamminen A, Tervahartiala P,<br />
Haapiainen R, Lehtonen T. Comparison of high-field<br />
magnetic resonance imaging with computed<br />
tomography in the evaluation of blunt renal trauma. J<br />
Trauma 1995: 38(3):420-427 [LoE 4].<br />
94 Leppaniemi A, Lamminen A, Tervahartiala P, Salo J,<br />
Haapiainen R, Lehtonen T. MRI and CT in blunt renal<br />
trauma: an update. Semin Ultrasound CT MR 1997:<br />
18(2):129-135 [LoE 4].<br />
95 Leppaniemi AK, Kivisaari AO, Haapiainen RK,<br />
Lehtonen TA. Role of magnetic resonance imaging in<br />
blunt renal parenchymal trauma. Br J Urol 1991:<br />
68(4):355-360 [LoE 4].<br />
Emergency room – Genitourinary tract 222
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
96 Levitt MA, Criss E, Kobernick M. Should the<br />
emergency IVP be used more selectively in blunt<br />
renal trauma? Ann Emerg Med 1985: 14(10):959-965<br />
[LoE 3].<br />
97 Levy JB, Baskin LS, Ewalt DH, Zderic SA, Bellah R,<br />
Snyder HM, III et al. Nonoperative management of<br />
blunt pediatric major renal trauma. Urology 1993:<br />
42(4):418-424 [LoE 4].<br />
98 Lis LE, Cohen AJ. CT cystography in the evaluation<br />
of bladder trauma. J Comput Assist Tomogr 1990:<br />
14(3):386-389 [LoE 4].<br />
99 Livingston DH, Lavery RF, Passannante MR,<br />
Skurnick JH, Fabian TC, Fry DE et al. Admission or<br />
observation is not necessary after a negative<br />
abdominal computed tomographic scan in patients<br />
with suspected blunt abdominal trauma: results of a<br />
prospective, multi-institutional trial. J Trauma 1998:<br />
44(2):273-280 [LoE 3].<br />
100 Lupetin AR, Mainwaring BL, Daffner RH. CT<br />
diagnosis of renal artery injury caused by blunt<br />
abdominal trauma. AJR Am J Roentgenol 1989:<br />
153(5):1065-1068 [LoE 4].<br />
101 Lynch D, Martinez-Pineiro L, las E, erafetinides E,<br />
urkeri L, ohenfellner M. Guidelines on urological<br />
trauma. http://uroweb.org/files/uploaded<br />
files/guidelines/urotrauma.pdf: Ezropean Association<br />
of Urology , 1-70. 2003 [Evidenzbasierte Leitlinie]<br />
102 Lynch TH, Martinez-Pineiro L, Plas E, Serafetinides<br />
E, Turkeri L, Santucci RA et al. EAU guidelines on<br />
urological trauma. Eur Urol 2005: 47(1):1-15<br />
[Evidenzbasierte Leitlinie]<br />
103 MacMahon R, Hosking D, Ramsey EW. Management<br />
of blunt injury to the lower urinary tract. Can J Surg<br />
1983: 26(5):415-418 [LoE 4].<br />
104 Mariani AJ, Luangphinith S, Loo S, Scottolini A,<br />
Hodges CV. Dipstick chemical urinalysis: an accurate<br />
cost-effective screening test. J Urol 1984: 132(1):64-<br />
66 [LoE 5].<br />
105 Matthews LA, Smith EM, Spirnak JP. Nonoperative<br />
treatment of major blunt renal lacerations with urinary<br />
extravasation. J Urol 1997: 157(6):2056-2058 [LoE<br />
4].<br />
106 Mayher BE, Guyton JL, Gingrich JR. Impact of<br />
urethral injury management on the treatment and<br />
outcome of concurrent pelvic fractures. Urology 2001:<br />
57(3):439-442 [LoE 4].<br />
107 Mayor B, Gudinchet F, Wicky S, Reinberg O,<br />
Schnyder P. Imaging evaluation of blunt renal trauma<br />
in children: diagnostic accuracy of intravenous<br />
pyelography and ultrasonography. Pediatr Radiol<br />
1995: 25(3):214-218 [LoE 4].<br />
108 McAndrew JD, Corriere JN, Jr. Radiographic<br />
evaluation of renal trauma: evaluation of 1103<br />
consecutive patients. Br J Urol 1994: 73(4):352-354<br />
[LoE 4].<br />
109 Medina D, Lavery R, Ross SE, Livingston DH.<br />
Ureteral trauma: preoperative studies neither predict<br />
injury nor prevent missed injuries. J Am Coll Surg<br />
1998: 186(6):641-644 [LoE 5].<br />
110 Mee SL, McAninch JW, Robinson AL, Auerbach PS,<br />
Carroll PR. Radiographic assessment of renal trauma:<br />
a 10-year prospective study of patient selection. J<br />
Urol 1989: 141(5):1095-1098 [LoE 1].<br />
111 Middlebrook PF, Schillinger JF. Hematuria and<br />
intravenous pyelography in pediatric blunt renal<br />
trauma. Can J Surg 1993: 36(1):59-62 [LoE 2].<br />
112 Miller DC, Forauer A, Faerber GJ. Successful<br />
angioembolization of renal artery pseudoaneurysms<br />
after blunt abdominal trauma. Urology 2002:<br />
59(3):444 [LoE 2].<br />
113 Miller KS, McAninch JW. Radiographic assessment<br />
of renal trauma: our 15-year experience. J Urol 1995:<br />
154(2 Pt 1):352-355 [LoE 2].<br />
114 Mohr AM, Pham AM, Lavery RF, Sifri Z, Bargman<br />
V, Livingston DH. Management of trauma to the male<br />
external genitalia: the usefulness of American<br />
Association for the Surgery of Trauma organ injury<br />
scales. J Urol 2003: 170(6 Pt 1):2311-2315 [LoE 4].<br />
115 Monstrey SJ, vander WC, Debruyne FM, Goris RJ.<br />
Urological trauma and severe associated injuries. Br J<br />
Urol 1987: 60(5):393-398 [LoE 4].<br />
116 Moore EE, Shackford SR, Pachter HL, McAninch<br />
JW, Browner BD, Champion HR et al. Organ injury<br />
scaling: spleen, liver, and kidney. J Trauma 1989:<br />
29(12):1664-1666.<br />
117 Morehouse DD, Mackinnon KJ. Posterior urethral<br />
injury: etiology, diagnosis, initial management. Urol<br />
Clin North Am 1977: 4(1):69-73.<br />
118 Morey AF, Hernandez J, McAninch JW.<br />
Reconstructive surgery for trauma of the lower<br />
urinary tract. Urol Clin North Am 1999: 26(1):49-60,<br />
viii.<br />
119 Morey AF, Iverson AJ, Swan A, Harmon WJ, Spore<br />
SS, Bhayani S et al. Bladder rupture after blunt<br />
trauma: guidelines for diagnostic imaging. J Trauma<br />
2001: 51(4):683-686.<br />
120 Morey AF, McAninch JW, Tiller BK, Duckett CP,<br />
Carroll PR. Single shot intraoperative excretory<br />
urography for the immediate evaluation of renal<br />
trauma. J Urol 1999: 161(4):1088-1092.<br />
121 Morgan DE, Nallamala LK, Kenney PJ, Mayo MS,<br />
Rue LW, III. CT cystography: radiographic and<br />
clinical predictors of bladder rupture. AJR Am J<br />
Roentgenol 2000: 174(1):89-95.<br />
122 Moudouni SM, Hadj SM, Manunta A, Patard JJ,<br />
Guiraud PH, Guille F et al. Management of major<br />
blunt renal lacerations: is a nonoperative approach<br />
indicated? Eur Urol 2001: 40(4):409-414.<br />
123 Moudouni SM, Patard JJ, Manunta A, Guiraud P,<br />
Guille F, Lobel B. A conservative approach to major<br />
blunt renal lacerations with urinary extravasation and<br />
devitalized renal segments. BJU Int 2001: 87(4):290-<br />
294.<br />
124 Mouraviev VB, Coburn M, Santucci RA. The<br />
treatment of posterior urethral disruption associated<br />
with pelvic fractures: comparative experience of early<br />
realignment versus delayed urethroplasty. J Urol<br />
2005: 173(3):873-876.<br />
125 Nagel R, Leistenschneider W. [Urologic injuries in<br />
patients with multiple injuries]. Chirurg 1978:<br />
49(12):731-736.<br />
Emergency room – Genitourinary tract 223
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
126 Nane I, Esen T, Tellaloglu S, Selhanoglu M, Akinci<br />
M. Penile fracture: emergency surgery for<br />
preservation of penile functions. Andrologia 1991:<br />
23(4):309-311.<br />
127 Netto Junior NR, Ikari O, Zuppo VP. Traumatic<br />
rupture of female urethra. Urology 1983: 22(6):601-<br />
603.<br />
128 Nicolaisen GS, McAninch JW, Marshall GA, Bluth<br />
RF, Jr., Carroll PR. Renal trauma: re-evaluation of the<br />
indications for radiographic assessment. J Urol 1985:<br />
133(2):183-187.<br />
129 Palmer JK, Benson GS, Corriere JN, Jr. Diagnosis and<br />
initial management of urological injuries associated<br />
with 200 consecutive pelvic fractures. J Urol 1983:<br />
130(4):712-714.<br />
130 Pao DM, Ellis JH, Cohan RH, Korobkin M. Utility of<br />
routine trauma CT in the detection of bladder rupture.<br />
Acad Radiol 2000: 7(5):317-324.<br />
131 P<strong>eng</strong> MY, Parisky YR, Cornwell EE, III, Radin R,<br />
Bragin S. CT cystography versus conventional<br />
cystography in evaluation of bladder injury. AJR Am J<br />
Roentgenol 1999: 173(5):1269-1272.<br />
132 Perez-Brayfield MR, Gatti JM, Smith EA, Broecker<br />
B, Massad C, Scherz H et al. Blunt traumatic<br />
hematuria in children. Is a simplified algorithm<br />
justified? J Urol 2002: 167(6):2543-2546.<br />
133 Peterson NE, Schulze KA. Selective diagnostic<br />
uroradiography for trauma. J Urol 1987: 137(3):449-<br />
451.<br />
134 Pfitzenmaier J, Buse S, Haferkamp A, Pahernik S,<br />
Djakovic N, Hohenfellner M. [Kidney trauma].<br />
Urologe A 2008: 47(6):759-767.<br />
135 Pfitzenmaier J, Buse S, Haferkamp A, Pahernik S,<br />
Hohenfellner M. Nierentrauma. Der Unfalllchirurg<br />
2009: 112:317-326.<br />
136 Podesta ML, Medel R, Castera R, Ruarte A.<br />
Immediate management of posterior urethral<br />
disruptions due to pelvic fracture: therapeutic<br />
alternatives. J Urol 1997: 157(4):1444-1448.<br />
137 Poletti PA, Kinkel K, Vermeulen B, Irmay F, Unger<br />
PF, Terrier F. Blunt abdominal trauma: should US be<br />
used to detect both free fluid and organ injuries?<br />
Radiology 2003: 227(1):95-103.<br />
138 Porter JR, Takayama TK, Defalco AJ. Traumatic<br />
posterior urethral injury and early realignment using<br />
magnetic urethral catheters. J Urol 1997: 158(2):425-<br />
430.<br />
139 Rehm CG, Mure AJ, O'Malley KF, Ross SE. Blunt<br />
traumatic bladder rupture: the role of retrograde<br />
cystogram. Ann Emerg Med 1991: 20(8):845-847.<br />
140 Rhea JT, Garza DH, Novelline RA. Controversies in<br />
emergency radiology. CT versus ultrasound in the<br />
evaluation of blunt abdominal trauma. Emerg Radiol<br />
2004: 10(6):289-295.<br />
141 Richman SD, Green WM, Kroll R, Casarella WJ.<br />
Superselective transcatheter embolization of traumatic<br />
renal hemorrhage. AJR Am J Roentgenol 1977:<br />
128(5):843-846.<br />
142 Robert M, Drianno N, Muir G, Delbos O, Guiter J.<br />
Management of major blunt renal lacerations: surgical<br />
or nonoperative approach? Eur Urol 1996: 30(3):335-<br />
339.<br />
143 Rose JS, Levitt MA, Porter J, Hutson A, Greenholtz J,<br />
Nobay F et al. Does the presence of ultrasound really<br />
affect computed tomographic scan use? A prospective<br />
randomized trial of ultrasound in trauma. J Trauma<br />
2001: 51(3):545-550.<br />
144 Routt ML, Simonian PT, Defalco AJ, Miller J, Clarke<br />
T. Internal fixation in pelvic fractures and primary<br />
repairs of associated genitourinary disruptions: a team<br />
approach. J Trauma 1996: 40(5):784-790.<br />
145 Russell RS, Gomelsky A, McMahon DR, Andrews D,<br />
Nasrallah PF. Management of grade IV renal injury in<br />
children. J Urol 2001: 166(3):1049-1050.<br />
146 Sandler CM, Goldman SM, Kawashima A. Lower<br />
urinary tract trauma. World J Urol 1998: 16(1):69-75.<br />
147 Santucci RA, McAninch JM. Grade IV renal injuries:<br />
evaluation, treatment, and outcome. World J Surg<br />
2001: 25(12):1565-1572.<br />
148 Santucci RA, McAninch JW, Safir M, Mario LA,<br />
Service S, Segal MR. Validation of the American<br />
Association for the Surgery of Trauma organ injury<br />
severity scale for the kidney. J Trauma 2001:<br />
50(2):195-200.<br />
149 Santucci RA, Wessells H, Bartsch G, Descotes J,<br />
Heyns CF, McAninch JW et al. Evaluation and<br />
management of renal injuries: consensus statement of<br />
the renal trauma subcommittee. BJU Int 2004:<br />
93(7):937-954.<br />
150 Schmidlin F. [Renal trauma. Treatment strategies and<br />
indications for surgical exploration]. Urologe A 2005:<br />
44(8):863-869.<br />
151 Shekarriz B, Stoller ML. The use of fibrin sealant in<br />
urology. J Urol 2002: 167(3):1218-1225.<br />
152 Singh PB, Karmakar D, Gupta RC, Dwivedi US,<br />
Tripathi VN. Result of suprapubic cystostomy only as<br />
primary management of posterior urethral rupture<br />
following pelvic fracture. Int Surg 1988: 73(1):59-62.<br />
153 Smith EM, Elder JS, Spirnak JP. Major blunt renal<br />
trauma in the pediatric population: is a nonoperative<br />
approach indicated? J Urol 1993: 149(3):546-548.<br />
154 Stein JP, Kaji DM, Eastham J, Freeman JA, Esrig D,<br />
Hardy BE. Blunt renal trauma in the pediatric<br />
population: indications for radiographic evaluation.<br />
Urology 1994: 44(3):406-410.<br />
155 St<strong>eng</strong>el D, Bauwens K, Porzsolt F, Rademacher G,<br />
Mutze S, Ekkernkamp A. [Emergency ultrasound for<br />
blunt abdominal trauma--meta-analysis update 2003].<br />
Zentralbl Chir 2003: 128(12):1027-1037.<br />
156 St<strong>eng</strong>el D, Bauwens K, Sehouli J, Porzsolt F,<br />
Rademacher G, Mutze S et al. Systematic review and<br />
meta-analysis of emergency ultrasonography for blunt<br />
abdominal trauma. Br J Surg 2001: 88(7):901-912.<br />
157 Taylor GA, Eichelberger MR, O'Donnell R, Bowman<br />
L. Indications for computed tomography in children<br />
with blunt abdominal trauma. Ann Surg 1991:<br />
213(3):212-218.<br />
158 Thall EH, Stone NN, Ch<strong>eng</strong> DL, Cohen EL, Fine EM,<br />
Leventhal I et al. Conservative management of<br />
penetrating and blunt Type III renal injuries. Br J Urol<br />
1996: 77(4):512-517.<br />
Emergency room – Genitourinary tract 224
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
159 Thambi Dorai CR, Boucaut HA, Dewan PA. Urethral<br />
injuries in girls with pelvic trauma. Eur Urol 1993:<br />
24(3):371-374.<br />
160 Thomae KR, Kilambi NK, Poole GV. Method of<br />
urinary diversion in nonurethral traumatic bladder<br />
injuries: retrospective analysis of 70 cases. Am Surg<br />
1998: 64(1):77-80.<br />
161 Thomason RB, Julian JS, Mostellar HC, Pennell TC,<br />
Meredith JW. Microscopic hematuria after blunt<br />
trauma. Is pyelography necessary? Am Surg 1989:<br />
55(3):145-150.<br />
162 Toutouzas KG, Karaiskakis M, Kaminski A,<br />
Velmahos GC. Nonoperative management of blunt<br />
renal trauma: a prospective study. Am Surg 2002:<br />
68(12):1097-1103.<br />
163 Uflacker R, Paolini RM, Lima S. Management of<br />
traumatic hematuria by selective renal artery<br />
embolization. J Urol 1984: 132(4):662-667.<br />
164 Vaccaro JP, Brody JM. CT cystography in the<br />
evaluation of major bladder trauma. Radiographics<br />
2000: 20(5):1373-1381.<br />
165 Venn SN, Greenwell TJ, Mundy AR. Pelvic fracture<br />
injuries of the female urethra. BJU Int 1999:<br />
83(6):626-630.<br />
166 Wah TM, Spencer JA. The role of CT in the<br />
management of adult urinary tract trauma. Clin Radiol<br />
2001: 56(4):268-277.<br />
167 Werkman HA, Jansen C, Klein JP, Ten Duis HJ.<br />
Urinary tract injuries in multiply-injured patients: a<br />
rational guideline for the initial assessment. Injury<br />
1991: 22(6):471-474.<br />
168 Wessells H, McAninch JW, Meyer A, Bruce J.<br />
Criteria for nonoperative treatment of significant<br />
penetrating renal lacerations. J Urol 1997: 157(1):24-<br />
27.<br />
169 Wolk DJ, Sandler CM, Corriere JN, Jr.<br />
Extraperitoneal bladder rupture without pelvic<br />
fracture. J Urol 1985: 134(6):1199-1201.<br />
170 Yoshii H, Sato M, Yamamoto S, Motegi M, Okusawa<br />
S, Kitano M et al. Usefulness and limitations of<br />
ultrasonography in the initial evaluation of blunt<br />
abdominal trauma. J Trauma 1998: 45(1):45-50.<br />
171 Zink RA, Muller-Mattheis V, Oberneder R. [Results<br />
of the West German multicenter study "Urological<br />
traumatology"]. Urologe A 1990: 29(5):243-250.<br />
172 Zwergel T, op den WR, Zwergel U, Schwaiger R,<br />
Muhr G, Ziegler M. [Concept of interdisciplinary<br />
procedures within the scope of traumatology--the<br />
status of urology]. Unfallchirurgie 1983: 9(5):244-<br />
248.<br />
Emergency room – Genitourinary tract 225
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.9 Spine<br />
A suspected spinal injury exists in principle in patients who are transferred to hospital with<br />
suspected multiple injuries. In our own hospital population between the years 2000-2002, 34% of<br />
the multiply injured patients (245 out of 720) had a spinal injury. Other studies have found a rate<br />
of 20% [29]. Conversely, about 1/3 of all spinal injuries are associated with concomitant injuries<br />
[34, 91]. Overall, the figure for Germany is approximately 10,000 serious spinal injuries per<br />
year, of which 1/5 involve the cervical spine and 4/5 the thoracic/lumbar spine [31].<br />
Approximately 10% of multiply injured patients will have a cervical spine injury [33]. At 1-27<br />
injuries/million children/year in Western Europe/North America, pediatric spinal injury is<br />
relatively rare [9].<br />
The presence of a spinal injury as part of multiple injuries has considerable consequences for the<br />
diagnostic study and therapeutic course of action. Typical concomitant injuries, e.g., thoracic or<br />
abdominal, must first be excluded. If surgical stabilization is necessary, a comprehensive preoperative<br />
CT diagnostic work-up is required of the injured region. Intensive care positioning<br />
options depend on the stability of a detected spinal injury. For this reason, it is desirable to assess<br />
the stability of a spinal injury if the general condition of the patient permits this (circulation,<br />
temperature, coagulation, intracranial pressure, etc.) and before the trauma patient is transferred<br />
from the emergency room or from the operating room to the intensive care unit.<br />
Medical history<br />
Key recommendation:<br />
The medical history has high importance and should be taken. GoR B<br />
Explanation:<br />
In the case of multiply injured patients, the medical history is usually taken from a third party.<br />
The mechanism of injury is an important piece of information here and should be passed on from<br />
the prehospital to the hospital care. Multiple injuries as such [4, 39, 49], high energy road traffic<br />
accidents [4, 16, 34, 101, 115, 149], road traffic accidents involving persons not restrained by<br />
belt or airbag [81, 101], pedestrians who have been run over [16], falls from a great height [14,<br />
39, 49, 128, 132], alcohol or drug influence [138], and advanced age [16, 100, 134] represent<br />
predispositions for a spinal injury. In the unconscious patient, the medical history should also<br />
include active movement of the extremities and information about pain before loss of<br />
consciousness or intubation.<br />
Traumatic brain injury and facial injuries are considered risk factors for the presence of a<br />
cervical spine injury. According to the multivariate analysis by Blackmore et al. [16], patients<br />
with a head fracture or continued unconsciousness have a markedly higher risk of having a<br />
cervical spine injury (odds ratio 8.5) whereas with milder injuries such as facial/jaw fracture or<br />
temporary unconsciousness, for example, this is less common (OR 2.6). Similarly, Hills and<br />
Deane [73] found that the risk of a cervical injury in patients with TBI is about 4 times higher<br />
than in patients without TBI. With a GCS below 8, the risk is actually 7 times higher. Other<br />
Emergency room – Spine 226
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
studies on the importance of traumatic brain injury [73, 83], loss of consciousness [46, 77, 79,<br />
131, 149], and craniofacial fractures [63, 73, 103, 122] confirm the association with spinal<br />
injuries. Only one study with a large number of patients described a tendentially reduced risk of<br />
cervical injuries in patients with facial or head injuries [165] but where the GCS was significant<br />
as a predictor. It is debatable whether clavicular fractures can also be considered as a predictor<br />
[165].<br />
Clinical examination<br />
Key recommendation:<br />
The clinical examination for spinal injuries has a high importance in the<br />
emergency room and should be carried out.<br />
Explanation:<br />
GoR B<br />
Due to its simplicity and speed, the clinical examination of the spine is a valuable diagnostic aid<br />
in the emergency room [49]. It comprises the inspection and palpation of the spine where<br />
contusions and hematomas are seen and displacement or malposition of the spinal process and<br />
indentations in the segments concerned can be felt. Information about pain in the head and torso<br />
can indicate a spinal injury. Tenderness, distraction or movement and involuntary malpositions<br />
are additional features of spinal injury [25, 128]. Provided the patient is conscious, motor<br />
functions and sensitivity should be tested. If there are existing deficits, the neurologic<br />
examination should document a precise, standardized finding, if possible according to the ASIA-<br />
IMSOP (American Spinal Injury Association - International Medical Society of Paraplegia)<br />
classification sheet [32, 33].<br />
Although there are well-validated clinical decision rules for monotrauma [11, 74, 150, 151] that<br />
enable a spinal injury to be definitely excluded, in turn saving on unnecessary diagnostic<br />
radiology, these decision rules cannot be transferred to polytrauma because prehospital<br />
interventions (particularly intubation) and concomitant injuries (particularly to the head)<br />
generally make it impossible to obtain a reliable medical history and carry out an examination<br />
[36, 159]. Thus, Cooper et al. [39] found that pain from a spinal fracture could only be found in<br />
63% of severely injured patients compared to 91% of the minor injured, patients with a TBI not<br />
being included. Meldon and Moettus reported quite similar figures (58% versus 93%) [105] so<br />
that a clinical examination was only considered reliable if there was a GCS of 15. Mirvis et al.<br />
and Barba et al. observed that about 10-20% of all apparently severely injured patients were<br />
actually less severely injured and thus adequately evaluable to be able to exclude a spinal injury<br />
clinically [12, 108]. This shows that the clinical examination of multiply injured patients is<br />
heavily dependent on the overall injury severity. The radiologic work-up of the spine can<br />
perhaps only be dispensed with in those cases where a patient is admitted with suspected<br />
multiple injuries but the injury severity then turns out to be less (ISS < 16). This is, however,<br />
outside the focus of this guideline. The clinical diagnostic study is not sufficiently reliable in<br />
polytrauma for clearing with adequate certainty a suspected spinal injury.<br />
Emergency room – Spine 227
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
On the other hand, if specific signs of a spinal injury are present, the clinical examination can<br />
affirm a suspected diagnosis [16, 59, 149]. Despite low sensitivity but due to its high positive<br />
predictive value (> 66%), the following signs permit the suspected diagnosis of spinal injury in<br />
polytrauma [80]: palpable step formation in the median-sagittal plane, pain on palpation,<br />
peripheral neurologic deficits or blood effusion around the spine. The papers by Holmes et al.<br />
[79], Gonzalez et al. [59], and Ross et al. 1992 [131] support the valency of the clinical finding.<br />
For the clinical examination, Gonzalez et al. and Holmes et al. report overall a sensitivity<br />
exceeding 90% in the cervical spine and up to 100% in the thoracic/lumbar spine but patients<br />
with a medical history of risk factors (painful or concomitant injuries affecting level of<br />
consciousness) were separately distinguished as a clinical risk group. These studies are thus not<br />
transferable to polytrauma.<br />
In unconscious trauma patients, slack muscle tone, particularly also the anal sphincter, lack of<br />
pain resistance, solely abdominal breathing, and priapism indicate a transverse lesion. Thus, the<br />
overall data status is somewhat better than the medical history for rating the clinical examination<br />
even if some of the studies have been conducted on monotrauma or mixed patient populations. In<br />
essence, a spinal injury can be predicted by the presence of clinical symptoms. Their absence,<br />
however, does not definitely exclude a spinal injury.<br />
Imaging diagnostic tests<br />
Key recommendation:<br />
After circulatory stabilization and before transfer to the intensive care unit, a<br />
spinal injury should be cleared by imaging diagnostic tests.<br />
Explanation:<br />
GoR B<br />
In principle, the diagnostic study of the spine should be concluded as early as possible because<br />
otherwise the continuing immobilization makes medical and nursing procedures more difficult<br />
(e.g., positioning, central venous access, intubation) and immobilization itself can lead to side<br />
effects (e.g., pressure sores, infection) [110, 161].<br />
The diagnostic work-up of the multiply injured patient with unstable circulation presents a<br />
chall<strong>eng</strong>e. Prioritization is applied here, giving priority to treatment and also surgery of lifethreatening<br />
injuries (e.g., epidural hematoma, pneumothorax). If this goal is achieved and there<br />
are no other contraindications (e.g., hypothermia), the spine is cleared by imaging technology as<br />
described above before transfer to the intensive care unit. If this is not advisable because of the<br />
situation, e.g., there is no current consequence, then the spine is usually cleared by imaging<br />
technology the next day, after stabilization of the overall condition [160].<br />
In individual cases, other injuries can make it necessary to dispense with the primary imaging<br />
diagnostic study of the spine [160]. If such be the case, the usual safety precautions must be<br />
applied until further notice: cervical collar, positioning and turning en bloc, re-positioning using<br />
a rollboard, vacuum mattress, etc. [56, 136]. “Excluded by imaging” means no dislocation or<br />
unstable spinal fracture in evaluable X-ray images or in a CT scan of the spine. The<br />
Emergency room – Spine 228
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
immobilization of the spine can only be terminated when the imaging diagnostic study has been<br />
completed or the patient has recovered sufficiently that a spinal injury can be excluded by the<br />
clinical finding. However, a few authors deliberately dispense with the primary diagnostic<br />
radiology in patients with minor injuries if it is foreseeable that the patient can be clinically<br />
evaluated again within 24 hours so that diagnostic radiology can definitely be circumvented [25].<br />
However, this is rarely the case in polytrauma so that this course of action is not recommended<br />
here.<br />
Key recommendation:<br />
Depending on the facilities of the admitting hospital, the spine should be<br />
cleared if circulation is stable during the emergency room diagnosis:<br />
preferably by multi-slice helical CT from head to pelvis or alternatively by<br />
conventional diagnostic radiology of the entire spine (a.p. and lateral,<br />
odontoid view).<br />
Explanation:<br />
GoR B<br />
Plain diagnostic radiology with focused CT work-up is clinically common in many cases [50,<br />
109]. The radiologic cervical work-up has the highest priority over the rest of the spine. This<br />
work-up is possible by means of CT and conventional diagnostic radiology (a.p., lateral, and<br />
odontoid view). A lateral-only view of the cervical spine has proved to be inadequate to enable<br />
bony injuries to be adequately excluded [37, 143, 152, 162, 169]. The following requirements<br />
must be met: all 7 cervical vertebrae should be viewed in the lateral plane [55, 111]. An a.p.<br />
projection should be taken of the C2-T1 spinous process; the C1 and C2 lateral masses should be<br />
easy to evaluate in the odontoid view [48]. The 45 ° oblique views for the C7/T1 alignment,<br />
swimmer’s and similar projections are of subordinate priority as they provide less informative<br />
value, waste time, and have a higher radiation dose [52, 102, 125]. If necessary, oblique views<br />
should take priority over swimmer’s views [84]. On the other hand, other authors have found that<br />
patients with inadequate visualization of the C7-T1 junction in the primary imaging were then<br />
better cleared using oblique views than using computed tomography [88] because the CT<br />
diagnostic study could be avoided in over 10% of all cases.<br />
Functional views of the cervical spine of unconscious patients should be held under image<br />
converters by the physician to exclude ligamentous injuries if there is justified suspicion [3, 45,<br />
97, 142]. Their sensitivity is 92%, their specificity 99% in patients with maintained<br />
consciousness [25]. However, as morbid findings are overall only seldom revealed in the<br />
functional views, the routine and also selective use of functional views in the primary diagnostic<br />
study is of questionable effectiveness [6, 62, 97, 121]. Computed tomography or particularly<br />
magnetic resonance imaging provides an alternative (see below).<br />
Missed musculo-skeletal injuries comprise approximately 12% in polytrauma [51]. The cervical<br />
spine is the first priority [5, 30, 133, 155]. The causes are radiology examinations that are<br />
inappropriate or not carried out, or a required diagnostic test not followed consistently [55, 104,<br />
106, 133], which is why CT should be used for clearance in unconscious patients with lack of<br />
Emergency room – Spine 229
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
visualization in the C0-C3 and C6/7 regions [25, 157]. Twenty per cent of spinal injuries are<br />
missed because the diagnostic study is incomplete [19, 42]. This is confirmed by data on 39<br />
multiply injured patients, 9 of whom had a cervical spine injury which could be diagnosed using<br />
conventional radiography in only 6 of these patients. In contrast, supplementary examinations<br />
(1x functional views and 2x CT) were necessary in the remaining 3 patients [141].<br />
The diagnosis of polytrauma contains per se a considerable risk that important injuries will be<br />
missed in the primary survey [129]. Fifty percent of missed injuries in polytrauma affect the<br />
whole spine. The result is an extended l<strong>eng</strong>th of hospital stay and additional follow-up operations<br />
[133]. It is therefore recommended in polytrauma to clear the whole spine as a matter of routine<br />
[44, 116]. Particularly in the case of blunt, high energy traumas and falls from a great height,<br />
injuries with second fractures at other levels are seen with a frequency of 10%. For this reason,<br />
thoracic and lumbar spine must also be X-rayed in 2 planes [32, 166].<br />
Computed tomography<br />
Key recommendation:<br />
Pathologic, suspect and non-evaluable regions in conventional radiography<br />
should be further cleared with CT.<br />
Explanation:<br />
GoR B<br />
Due to greater diagnostic accuracy in detecting spinal injuries, preference should be given to the<br />
CT diagnostic test, if available [7]. Another practical advantage of the CT diagnostic test is the<br />
markedly faster clearing of the spine compared to conventional diagnostic radiology [68, 71, 72]<br />
because non-evaluable views virtually no longer occur. The CT diagnostic test is usually<br />
performed with administration of i.v. contrast agent. The CT diagnostic test is also considered to<br />
be advantageous in children even though the radiation dose at approximately 400 mrem<br />
(millirem) is higher than in conventional diagnostic radiology (150-300 mrem), as shown by a<br />
pseudo-randomized study [2]. Despite the above-mentioned problems, it is recommended that<br />
the options for clinical findings are exhausted fully in children [65]. Essentially, the procedure<br />
for children in the emergency room is no different from that for adults.<br />
Detected spinal injuries should not be operated on without CT [75] as fracture evaluation and<br />
classification is often changed decisively through CT compared to the plain radiograph [68, 70].<br />
The preceding CT visualization and analysis is necessary particularly for rotationally unstable<br />
fractures [144]. The helical CT examination from head to pelvis without conventional diagnostic<br />
radiology is particularly suitable for clearing the spine in polytrauma because it saves time, has<br />
greater reliability compared to conventional diagnostic radiology, is associated with less<br />
discomfort, and costs less [112]. If the spine is visualized normally in the CT, additional<br />
conventional radiology is superfluous [26, 28, 35, 123, 135] as the negative predictive value<br />
reaches almost 100%. With today’s permanent availability, the CT diagnostic study appears at<br />
present to be the tool of choice for detecting spinal injuries in polytrauma in the emergency room<br />
phase [86].<br />
Emergency room – Spine 230
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Cervical spine (C)<br />
Harris et al. (2000) [66] describe the conventional diagnostic radiology in cervical spine injuries<br />
as not satisfactory so that CT or, if applicable, magnetic resonance imaging (MRI) is<br />
recommended particularly in polytrauma. CT is markedly more accurate than conventional<br />
diagnostic radiology for cervical spine injuries: The cervical spine injury was detected in 38 out<br />
of 70 patients using the conventional X-ray image and 67 out of the same 70 patients using CT<br />
[139]. Similar results are provided by a current meta-analysis [78] and the reviews by Crim et al.<br />
(2001) [41] and Link et al. (1994) [99]: using conventional lateral radiographs, 60-80% of<br />
cervical spine injuries were identified, and 97-100% with CT [119] (Table 2). Further studies<br />
show that the layer thickness in computed tomography affects the diagnostic accuracy [70],<br />
which must also be taken into account when assessing older studies with CT equipment which is<br />
obsolete by today’s standards.<br />
Based on the figures in the literature, Blackmore et al. also come to the conclusion that the<br />
primary CT diagnostic study has better clinical and economic results compared to conventional<br />
radiography in patients with average and high risk of a spinal injury [17].<br />
Thoracic/lumbar spine (T/L)<br />
Table 3 gives a summary of important studies on the CT diagnostic test in the emergency room<br />
for thoracic/lumbar spine injuries as part of polytrauma. This also shows a clearly greater<br />
sensitivity of the CT diagnostic test compared to the conventional diagnostic test. It must be<br />
noted that not all additional findings such as transverse process avulsions were clinically relevant<br />
in the CT but could easily refer to other relevant injuries (abdominal injuries). In addition, there<br />
are advantages with regard to time and planning of surgery. According to Hauser et al. (2003)<br />
[68], the time for sufficient clearing of the spine was 3 hours for conventional diagnostic<br />
radiology, and one hour for CT. Moreover, the rate of false fracture classifications in CT was<br />
1.4% and in radiography 12.6%.<br />
Concomitant injuries in head/thorax/abdomen<br />
To clear the spine and concomitant injuries in polytrauma, a standard CT from head to pelvis is<br />
recommended initially in polytrauma, which takes approximately 20 minutes [96]. Computed<br />
tomography is indicated on the day of admission particularly for cervical spine injuries combined<br />
with TBI [141]. For thoracic spine fractures, the emergency CT examination of the thorax is<br />
indicated because of the high risk of complex thoracic-pulmonary injuries [58]. The constellation<br />
of lumbar spine injuries and abdominal trauma in the form of bleeding into the abdominal wall<br />
after a belt injury also supports the clearing of the spinal injury by CT in order to enable a<br />
simultaneous evaluation of the abdomen [13]. Miller et al. (2000) [107] and Patten et al. (2000)<br />
[117] also refer to the importance of transverse process fractures in the lumbar spine as important<br />
indications of a concomitant abdominal injury, which is why CT is recommended. Moreover,<br />
clearing the thoracic-lumbar spine by CT is also recommended for acetabular and pelvic<br />
fractures [8, 70]. In conventional diagnostic radiology, significant spinal fractures are missed in<br />
11% of cases of transverse process fractures. These are only picked up by CT, which is why it is<br />
stated that CT is necessary for clearing these fractures [92].<br />
Emergency room – Spine 231
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Magnetic resonance imaging (MRI)<br />
Magnetic resonance imaging examinations play a quantitatively subordinate role overall in<br />
polytrauma during the emergency room phase [148]. For logistic reasons (access, metal objects,<br />
time, availability), an MRI examination in the acute phase is usually not expedient for<br />
polytrauma. The main indication for MRI is in clearing unclear neurologic deficits. In particular,<br />
lesions on the spinal cord, the invertebral disc, and ligaments can be visualized [41, 57, 89].<br />
However, in view of the rarity of this injury, Patton et al. [118] considered a search for<br />
ligamentous injuries using MRI to be superfluous. There are no studies on the direct comparison<br />
between conventional functional views and MRI imaging so that both options appear to be<br />
worthy of recommendation. With a sensitivity of only 12% and a specificity of 97%, MRI is<br />
little suited to the detection of fractures [90].<br />
MRI examinations are indicated for neurologic symptoms during the further course and have<br />
partially replaced the functional views for defined research questions such as in the case of the<br />
hangman fracture, for example [87]. In general, there is no need to worry about false-negative<br />
results but specificity is low [25]. If a neurologic deficit without morphologic correlation is<br />
present in the CT, the corresponding spinal segment must be examined by MRI as a matter of<br />
urgency. Additional indications arise occasionally in the early post-operative or post-traumatic<br />
course to be able to evaluate, e.g., intraspinal epidural hematomas, prevertebral bleeding or<br />
invertebral disc injuries [43, 147, 163].<br />
Emergency procedures such as reduction and cortisone treatment<br />
Key recommendations:<br />
In the exceptional case of a closed emergency reduction of the spine, this<br />
should only be carried out after sufficient CT diagnostic study of the injury.<br />
Administration of methyl prednisolone (“NASCIS scheme”) is no longer<br />
standard practice but can be introduced within 8 hours after the accident if<br />
there is neurologic deficit and evidence of injury.<br />
Explanation:<br />
GoR B<br />
GoR 0<br />
A precise analysis of the spinal injury must be made before each reduction, i.e. preceded by a<br />
careful analysis of the imaging (CT). Despite the poor quality of evidence, the recommendation<br />
has been upgraded because of the risk of complication. Generally, reduction is directly carried<br />
out preoperatively in the operating room or open during surgery, followed by surgical<br />
stabilization of the reduced injury. Care must be taken in closed reduction without surgical<br />
stabilization or invertebral disc removal as it can herniate dorsally during reduction and have a<br />
detrimental effect on the neurology [60].<br />
A Cochrane Review [21] found on the basis of 3 randomized studies [22, 114, 120] that,<br />
compared to a placebo, methyl prednisolone improves the neurologic outcome one year after the<br />
Emergency room – Spine 232
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
accident if it is given within 8 hours after the accident. The recommended dose (“NASCIS<br />
scheme”) is methyl prednisolone 30 mg/kg body weight i.v. over 15 minutes in the first 8 hours<br />
after the accident, thereafter 5.4 mg/kg BW each hour for 23 hours. In the NASCIS-3 study,<br />
administration of methyl prednisolone over 48 hours proved at best to have a trend towards<br />
improvement [23] and was recommended only for patients who could be started on the treatment<br />
after 3 or more hours.<br />
If there is evidence of neurologic symptoms or they can be assumed, with corresponding CT<br />
morphologic evidence of narrowing of the spinal canal, a NASCIS (National Acute Spinal Cord<br />
Injury Study) scheme can be started early [10]. The rehabilitation time can thus be shortened.<br />
However, other analyses show no effect from cortisone treatment [145, 146] or do not<br />
recommend cortisone treatment because the positive effect was not seen [82]. In addition, the<br />
validity of the NASCIS-2 study has been questioned [38]. The more recent results on<br />
administering corticosteroids for TBI [40] also cast a shadow on the efficacy of steroids for<br />
spinal cord trauma.<br />
Although, overall, the high-dose steroid administration to surgical/traumatologic patients can be<br />
seen as safe and to some extent even as advantageous [130, 137, 154], the possible side effects<br />
are an important argument against administration of steroids according to the NASCIS protocol<br />
[94, 153]. Known complications of steroid treatment in patients with spinal cord injury are:<br />
infections [53, 54], pancreatitis [69], myopathies [124], psychologic problems [158], and severe<br />
lactic acidosis when combined with the high dose of methyl prednisolone with i.v. adrenaline<br />
supply [67].<br />
Emergency room – Spine 233
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Acheson Mb, Livingston Rr, Richardson Ml et al.<br />
(1987) High-resolution CT scanning in the evaluation<br />
of cervical spine fractures: comparison with plain film<br />
examinations. AJR Am J Roentgenol 148:1179-1185<br />
2. Adelgais Km, Grossman Dc, Langer Sg et al. (2004)<br />
Use of helical computed tomography for imaging the<br />
pediatric cervical spine. Acad Emerg Med 11:228-236<br />
[LoE 2b]<br />
3. Ajani Ae, Cooper Dj, Scheinkestel Cd et al. (1998)<br />
Optimal assessment of cervical spine trauma in<br />
critically ill patients: a prospective evaluation.<br />
Anaesth Intensive Care 26:487-491 [LoE 4]<br />
4. Albrecht Rm, Malik S, Kingsley Dd et al. (2003)<br />
Severity of cervical spine ligamentous injury<br />
correlates with mechanism of injury, not with severity<br />
of blunt head trauma. Am Surg 69:261-265 [LoE 4]<br />
5. Alker Gj, Oh Ys, Leslie Ev et al. (1975) Postmortem<br />
radiology of head neck injuries in fatal traffic<br />
accidents. Radiology 114:611-617 [LoE 4]<br />
6. Anglen J, Metzler M, Bunn P et al. (2002) Flexion<br />
and extension views are not cost-effective in a<br />
cervical spine clearance protocol for obtunded trauma<br />
patients. J Trauma 52:54-59 [LoE 4]<br />
7. Antevil Jl, Sise Mj, Sack Di et al. (2006) Spiral<br />
computed tomography for the initial evaluation of<br />
spine trauma: A new standard of care? J Trauma<br />
61:382-387<br />
8. Archdeacon Mt, Anderson R, Harris Am et al. (2006)<br />
Concomitant fractures of the acetabulum and spine: a<br />
retrospective review of over 300 patients. J Trauma<br />
60:609-612<br />
9. Augutis M, Levi R (2003) Pediatric spinal cord injury<br />
in Sweden: incidence, etiology and outcome. Spinal<br />
Cord 41:328-336<br />
10. Bagnall Am, Jones L, Richardson G et al. (2003)<br />
Effectiveness and cost-effectiveness of acute hospitalbased<br />
spinal cord injuries services: systematic review.<br />
Health Technol Assess 7: 1-92 [LoE 1a]<br />
11. Bandiera G, Stiell Ig, Wells Ga et al. (2003) The<br />
Canadian C-spine rule performs better than<br />
unstructured physician judgment. Ann Emerg Med<br />
42:395-402 [LoE 1b]<br />
12. Barba Ca, Taggert J, Morgan As et al. (2001) A new<br />
cervical spine clearance protocol using computed<br />
tomography. J Trauma 51:652-657 [LoE 4]<br />
13. Beaunoyer M, St-Vil D, Lallier M et al. (2001)<br />
Abdominal injuries associated with thoraco-lumbar<br />
fractures after motor vehicle collision. J Pediatr Surg<br />
36:760-762 [LoE 4]<br />
14. Bensch Fv, Kiuru Mj, Koivikko Mp et al. (2004)<br />
Spine fractures in falling accidents: analysis of<br />
multidetector CT findings. Eur Radiol 14:618-624<br />
[LoE 4]<br />
15. Berne Jd, Velmahos Gc, El-Tawil Q et al. (1999)<br />
Value of complete cervical helical computed<br />
tomographic scanning in identifying cervical spine<br />
injury in the unevaluable blunt trauma patient with<br />
multiple injuries: a prospective study. J Trauma<br />
47:896-903<br />
16. Blackmore Cc, Emerson Ss, Mann Fa et al. (1999)<br />
Cervical spine imaging in patients with trauma:<br />
determination of fracture risk to optimize use.<br />
Radiology 211:759-765 [LoE 4]<br />
17. Blackmore Cc, Ramsey Sd, Mann Fa et al. (1999)<br />
Cervical spine screening with CT in trauma patients: a<br />
cost-effectiveness analysis. Radiology 212:117-125<br />
[LoE 5]<br />
18. Blacksin Mf, Lee Hj (1995) Frequency and<br />
significance of fractures of the upper cervical spine<br />
detected by CT in patients with severe neck trauma.<br />
AJR Am J Roentgenol 165:1201-1204<br />
19. Blauth M, Knop C, Bastian L et al. (1998) Komplexe<br />
Verletzungen der Wirbelsäule. Orthopäde 27:17-31<br />
[LoE 5]<br />
20. Borock Ec, Gabram Sg, Jacobs Lm et al. (1991) A<br />
prospective analysis of a two-year experience using<br />
computed tomography as an adjunct for cervical spine<br />
clearance. J Trauma 31:1001-1006<br />
21. Bracken Mb (2002) Steroids for acute spinal cord<br />
injury. Cochrane Database Syst Rev:CD001046 [LoE<br />
1a]<br />
22. Bracken Mb, Shepard Mj, Collins Wf et al. (1990) A<br />
randomized, controlled trial of methylprednisolone or<br />
naloxone in the treatment of acute spinal-cord injury.<br />
Results of the Second National Acute Spinal Cord<br />
Injury Study. N Engl J Med 322:1405-1411 [LoE 1b]<br />
23. Bracken Mb, Shepard Mj, Holford Tr et al. (1997)<br />
Administration of methylprednisolone for 24 or 48<br />
hours or tirilazad mesylate for 48 hours in the<br />
treatment of acute spinal cord injury. Results of the<br />
Third National Acute Spinal Cord Injury Randomized<br />
Controlled Trial. JAMA 277:1597-1604 [LoE 1b]<br />
24. Brandt Mm, Wahl Wl, Yeom K et al. (2004)<br />
Computed tomographic scanning reduces cost and<br />
time of complete spine evaluation. J Trauma 56:1022-<br />
1028<br />
25. British Trauma Society (2003) Guidelines for the<br />
initial management and assessment of spinal injury.<br />
Injury 34:405-425 [Evidenzbasierte Leitlinie]<br />
26. Brohi K, Healy M, Fotheringham T et al. (2005)<br />
Helical computed tomographic scanning for the<br />
evaluation of the cervical spine in the unconscious,<br />
intubated trauma patient. J Trauma 58:897-901 [LoE<br />
4]<br />
27. Brooks Ra, Willett Km (2001) Evaluation of the<br />
Oxford protocol for total spinal clearance in the<br />
unconscious trauma patient. J Trauma 50:862-867<br />
28. Brown Cvr, Antevil Jl, Sise Mj et al. (2005) Spiral<br />
computed tomography for the diagnosis of cervical,<br />
thoracic, and lumbar spine fractures: its time has<br />
come. J Trauma 58:890-896 [LoE 4]<br />
29. Buchinger W (1999) [Vertebromedullary injuries in<br />
polytrauma]. Anasthesiol Intensivmed Notfallmed<br />
Schmerzther 34 Suppl 1:S28-31<br />
30. Bucholz Rw, Burkhead Wz, Graham W et al. (1979)<br />
Occult cervical spine injuries in fatal traffic accidents.<br />
J Trauma 19:768-771 [LoE 4]<br />
Emergency room – Spine 234
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
31. Buhren V (2003) [Injuries to the thoracic and lumbar<br />
spine]. Unfallchirurg 106:55-68; quiz 68-59<br />
32. Bühren V (2003) Frakturen und Instabilitäten der<br />
Brust- und Lendenwirbelsäule. Unfallchirurg 106:55-<br />
69 [LoE 5]<br />
33. Bühren V (2002) Frakturen und Instabilitäten der<br />
Halswirbelsäule. Unfallchirurg 105:1049-1066<br />
34. Burney Re, Maio Rf, Maynard F et al. (1993)<br />
Incidence, characteristics, and outcome of spinal cord<br />
injury at trauma centers in North America. Arch Surg<br />
128:596-599 [LoE 4]<br />
35. Calendine Cl, Fajman Wa, Hanna Sl et al. (2002) Is<br />
there need for thoracic spine radiographs following a<br />
negative chest CT in trauma patients? Emerg Radiol<br />
9:254-256 [LoE 4]<br />
36. Chang Ch, Holmes Jf, Mower Wr et al. (2005)<br />
Distracting injuries in patients with vertebral injuries.<br />
J Emerg Med 28:147-152 [LoE 4]<br />
37. Cohn Sm, Lyle Wg, Linden Ch et al. (1991) Exclusion<br />
of cervical spine injury: a prospective study. J Trauma<br />
31:570-574 [LoE 4]<br />
38. Coleman Wp, Benzel D, Cahill Dw et al. (2000) A<br />
critical appraisal of the reporting of the National<br />
Acute Spinal Cord Injury Studies (II and III) of<br />
methylprednisolone in acute spinal cord injury. J<br />
Spinal Disord 13:185-199 [LoE 5]<br />
39. Cooper C, Dunham Cm, Rodriguez A (1995) Falls<br />
and major injuries are risk factors for thoracolumbar<br />
fractures: cognitive impairment and multiple injuries<br />
impede the detection of back pain and tenderness. J<br />
Trauma 38:692-696 [LoE 4]<br />
40. Crash Trial Collaborators (2004) Effect of intravenous<br />
corticosteroids on death within 14 days in 10.008<br />
adults with clinically significant head injury (MRC<br />
CRASH trial): randomised placebo-controlled trial.<br />
Lancet 364:1321-1328 [LoE 1b]<br />
1. Crim Jr, Moore K, Brodke D (2001) Clearance of the<br />
cervical spine in multitrauma patients: the role of<br />
advanced imaging. Semin Ultrasound CT MR 22:283-<br />
305 [LoE 5]<br />
42. Cusmano F, Ferrozzi F, Uccelli M et al. (1999)<br />
Fratture dei primi due metameri cervicali. Cause di<br />
errore diagnostico. Radiol Med (Torino) 98:230-235<br />
[LoE 4]<br />
43. D'alise Md, Benzel Ec, Hart Bl (1999) Magnetic<br />
resonance imaging evaluation of the cervical spine in<br />
the comatose or obtunded trauma patient. J Neurosurg<br />
91:54-59 [LoE 4]<br />
44. Dai Ly, Yao Wf, Cui Ym et al. (2004) Thoracolumbar<br />
fractures in patients with multiple injuries: diagnosis<br />
and treatment-a review of 147 cases. J Trauma<br />
56:348-355 [LoE 4]<br />
45. Davis Jw, Parks Sn, Detlefs Cl et al. (1995) Clearing<br />
the cervical spine in obtunded patients: the use of<br />
dynamic fluoroscopy. J Trauma 39:435-438 [LoE 4]<br />
46. Demetriades D, Charalambides K, Chahwan S et al.<br />
(2000) Nonskeletal cervical spine injuries:<br />
epidemiology and diagnostic pitfalls. J Trauma<br />
48:724-727 [LoE 4]<br />
47. Diaz Jj, Jr., Gillman C, Morris Ja, Jr. et al. (2003) Are<br />
five-view plain films of the cervical spine unreliable?<br />
A prospective evaluation in blunt trauma patients with<br />
altered mental status. J Trauma 55:658-664<br />
48. Digiacomo Jc, Frankel Hl, Rotondo Mf (2002)<br />
Clearing the cervical spine in victims of blunt trauma.<br />
Mil Med 167:398-401 [LoE 4]<br />
49. Durham Rm, Luchtefeld Wb, Wibbenmeyer L et al.<br />
(1995) Evaluation of the thoracic and lumbar spine<br />
after blunt trauma. Am J Surg 170:681-685 [LoE 4]<br />
50. Eastern Association for Trauma (East) Practice<br />
Management Guidelines Work Group (2000) Practice<br />
management guidelines for identifying cervical spine<br />
injuries following trauma.[at<br />
http://www.east.org/tpg.html] [Evidenzbasierte<br />
Leitlinie]<br />
51. Enderson Bl, Reath Db, Meadors J et al. (1990) The<br />
tertiary trauma survey: a prospective study of missed<br />
injury. J Trauma 30:666-670 [LoE 4]<br />
52. Freemyer B, Knopp R, Piche J et al. (1989)<br />
Comparison of five-view and three-view cervical<br />
spine series in the evaluation of patients with cervical<br />
trauma. Ann Emerg Med 18:818-821 [LoE 2b]<br />
53. Galandiuk S, Raque G, Appel S et al. (1993) The twoedged<br />
sword of large-dose steroids for spinal cord<br />
trauma. Ann Surg 218:419-427 [LoE 2b]<br />
54. Gerndt Sj, Rodriguez Jl, Pawlik Jw et al. (1997)<br />
Consequences of high-dose steroid therapy for acute<br />
spinal cord injury. J Trauma 42:279-284 [LoE 2b]<br />
55. Gerrelts Bd, Petersen Eu, Mabry J et al. (1991)<br />
Delayed diagnosis of cervical spine injuries. J Trauma<br />
31:1622-1626 [LoE 4]<br />
56. Gertzbein Sd (1994) Neurologic deterioration in<br />
patients with thoracic and lumbar fractures after<br />
admission to the hospital. Spine 19:1723-1725 [LoE<br />
4]<br />
57. Ghanta Mk, Smith Lm, Polin Rs et al. (2002) An<br />
analysis of Eastern Association for the Surgery of<br />
Trauma practice guidelines for cervical spine<br />
evaluation in a series of patients with multiple<br />
imaging techniques. Am Surg 68:563-568<br />
[Evidenzbasierte Leitlinie]<br />
58. Glaesener Jj, Hasse W, Exner G et al. (1992)<br />
Thorakopulmonale Komplikationen bei frischen<br />
Frakturen der Brustwirbelsäule mit neurologischem<br />
Schaden. Unfallchirurgie 18:274-279 [LoE 4]<br />
59. Gonzalez Rp, Fried Po, Bukhalo M et al. (1999) Role<br />
of clinical examination in screening for blunt cervical<br />
spine injury. J Am Coll Surg 189:152-157 [LoE 4]<br />
60. Grant Ga, Mirza Sk, Chapman Jr et al. (1999) Risk of<br />
early closed reduction in cervical spine subluxation<br />
injuries. J Neurosurg Spine 90:13-18 [LoE 4]<br />
61. Griffen Mm, Frykberg Er, Kerwin Aj et al. (2003)<br />
Radiographic clearance of blunt cervical spine injury:<br />
plain radiograph or computed tomography scan? J<br />
Trauma 55:222-227<br />
62. Griffiths Hj, Wagner J, Anglen J et al. (2002) The use<br />
of forced flexion/extension views in the obtunded<br />
trauma patient. Skeletal Radiol 31:587-591 [LoE 4]<br />
63. Hackl W, Fink C, Hausberger K et al. (2001) The<br />
incidence of combined facial and cervical spine<br />
injuries. J Trauma 50:41-45 [LoE 4]<br />
Emergency room – Spine 235
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
64. Hadley Mn, Walters Bc, Grabb Pa et al. (2002)<br />
Guidelines for the management of acute cervical spine<br />
and spinal cord injuries. Clin Neurosurg 49:407-498<br />
[Evidenzbasierte Leitlinie]<br />
65. Hanson Ja, Blackmore Cc, Mann Fa et al. (2000)<br />
Cervical spine injury: a clinical decision rule to<br />
identify high-risk patients for helical CT screening.<br />
AJR Am J Roentgenol 174:713-717 [LoE 1b]<br />
66. Harris Mb, Kronlage Sc, Carboni Pa et al. (2000)<br />
Evaluation of the cervical spine in the polytrauma<br />
patient. Spine 25:2884-2892<br />
67. Hasse W, Weidtmann A, Voeltz P (2000)<br />
Laktatazidose: ein Komplikation beim<br />
querschnittgelähmten <strong>Polytrauma</strong>. Unfallchirurg<br />
103:495-498 [LoE 4]<br />
68. Hauser Cj, Visvikis G, Hinrichs C et al. (2003)<br />
Prospective validation of computed tomographic<br />
screening of the thoracolumbar spine in trauma. J<br />
Trauma 55:228-235 [LoE 3b]<br />
69. Heary Rf, Vaccaro Ar, Mesa Jj et al. (1997) Steroids<br />
and gunshot wounds to the spine. Neurosurgery<br />
41:576-584 [LoE 2b]<br />
70. Herzog C, Ahle H, Mack Mg et al. (2004) Traumatic<br />
injuries of the pelvis and thoracic and lumbar spine:<br />
does thin-slice multidetector-row CT increase<br />
diagnostic accuracy? Eur Radiol 14:1751-1760 [LoE<br />
2b]<br />
71. Heuchemer T, Waidelich H, Haberle Hj et al. (1992)<br />
Diagnostik des Wirbelsäulentraumas: Indikation zur<br />
CT und Myelo-CT am Unfalltag. Röfo Fortschr<br />
Röntgenstr 156:156-159 [LoE 4]<br />
72. Heyer Cm, Rduch Gj, Wick M et al. (2005)<br />
[Evaluation of multiple trauma victims with 16-row<br />
multidetector CT (MDCT): a time analysis]. Rofo<br />
177:1677-1682 [LoE 4]<br />
73. Hills Mw, Deane Sa (1993) Head injury and facial<br />
injury: is there an increased risk of cervical spine<br />
injury? J Trauma 34:549-554 [LoE 4]<br />
74. Hoffman Jr, Mower Wr, Wolfson Ab et al. (2000)<br />
Validity of a set of clinical criteria to rule out injury to<br />
the cervical spine in patients with blunt trauma. N<br />
Engl J Med 343:94-99 [LoE 1b]<br />
75. Hofmann D (1992) <strong>Polytrauma</strong>management:<br />
Möglichkeiten und Grenzen eines<br />
Allgemeinkrankenhauses. Unfallchirurgie 18:105-110<br />
[LoE 4]<br />
76. Holley J, Jorden R (1989) Airway management in<br />
patients with unstable cervical spine fractures. Ann<br />
Emerg Med 18:1237-1239 [LoE 4]<br />
77. Holly Lt, Kelly Df, Counelis Gj et al. (2002) Cervical<br />
spine trauma associated with moderate and severe<br />
head injury: incidence, risk factors, and injury<br />
characteristics. J Neurosurg Spine 96:285-291 [LoE 4]<br />
78. Holmes Jf, Akkinepalli R (2005) Computed<br />
tomography versus plain radiography to screen for<br />
cervical spine injury: a meta-analysis. J Trauma<br />
58:902-905 [LoE 1a]<br />
79. Holmes Jf, Panacek Ea, Miller Pq et al. (2003)<br />
Prospective evaluation of criteria for obtaining<br />
thoracolumbar radiographs in trauma patients. J<br />
Emerg Med 24:1-7 [LoE 4]<br />
80. Hsu Jm, Joseph T, Ellis Am (2003) Thoracolumbar<br />
fracture in blunt trauma patients: guidelines for<br />
diagnosis and imaging. Injury 34:426-433<br />
[Evidenzbasierte Leitlinie]<br />
81. Huelke Df, Mackay Gm, Morris A (1995) Vertebral<br />
column injuries and lap-shoulder belts. J Trauma<br />
38:547-556 [LoE 4]<br />
82. Hurlbert Rj (2000) Methylprednisolone for acute<br />
spinal cord injury: an inappropriate standard of care. J<br />
Neurosurg Spine 93:1-7<br />
83. Iida H, Tachibana S, Kitahara T et al. (1999)<br />
Association of head trauma with cervical spine injury,<br />
spinal cord injury, or both. J Trauma 46:450-452 [LoE<br />
4]<br />
84. Ireland Aj, Britton I, Forrester Aw (1998) Do supine<br />
oblique views provide better imaging of the<br />
cervicothoracic junction than swimmer's views? J<br />
Accid Emerg Med 15:151-154 [LoE 4]<br />
85. Jelly Lme, Evans Dr, Easty Mj et al. (2000)<br />
Radiography versus spiral CT in the evaluation of<br />
cervicothoracic junction injuries in polytrauma<br />
patients who have undergone intubation.<br />
Radiographics 20 Spec No:S251-S262<br />
86. Josten C, Katscher S (2003) Radiologische Diagnostik<br />
bei Wirbelsäulenverletzungen. Aktuelle Traumatol<br />
33:157-164 [LoE 5]<br />
87. Junge A, El-Sheik M, Celik I et al. (2002)<br />
Pathomorphologische Diagnostik und Behandlung der<br />
Hangman-Fraktur. Unfallchirurg 105:775-782 [LoE 4]<br />
88. Kaneriya Pp, Schweitzer Me, Spettell C et al. (1998)<br />
The cost-effectiveness of oblique radiography in the<br />
exclusion of C7-T1 injury in trauma patients. AJR Am<br />
J Roentgenol 171:959-962 [LoE 4]<br />
89. Katzberg Rw, Benedetti Pf, Drake Cm et al. (1999)<br />
Acute cervical spine injuries: prospective MR imaging<br />
assessment at a level 1 trauma center. Radiology<br />
213:203-212 [LoE 4]<br />
90. Klein Gr, Vaccaro Ar, Albert Tj et al. (1999) Efficacy<br />
of magnetic resonance imaging in the evaluation of<br />
posterior cervical spine fractures. Spine 24:771-774<br />
[LoE 2b]<br />
91. Knop C, Blauth M, Bühren V et al. (1999) Operative<br />
Behandlung von Verletzungen des thorakolumbalen<br />
übergangs. Teil 1: Epidemiologie. Unfallchirurg<br />
102:924-935<br />
92. Krueger Ma, Green Da, Hoyt D et al. (1996)<br />
Overlooked spine injuries associated with lumbar<br />
transverse process fractures. Clin Orthop Relat<br />
Res:191-195<br />
93. Lawrason Jn, Novelline Ra, Rhea Jt et al. (2001) Can<br />
CT eliminate the initial portable lateral cervical spine<br />
radiograph in the multiple trauma patient? A review of<br />
200 cases. Emerg Radiol 8:272-275<br />
94. Lee Hc, Cho Dy, Lee Wy et al. (2007) Pitfalls in<br />
treatment of acute cervical spinal cord injury using<br />
high-dose methylprednisolone: a retrospect audit of<br />
111 patients. Surg Neurol 68 Suppl 1:<strong>S3</strong>7-41;<br />
discussion S41-32<br />
95. Lee Hj, Sharma V, Shah K et al. (2001) The role of<br />
spiral CT vs plain films in acute cervical spine<br />
trauma: a comparative study. Emerg Radiol 8:311-314<br />
Emergency room – Spine 236
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
96. Leidner B, Adiels M, Aspelin P et al. (1998)<br />
Standardized CT examination of the multitraumatized<br />
patient. Eur Radiol 8:1630-1638<br />
97. Lewis Lm, Docherty M, Ruoff Be et al. (1991)<br />
Flexion-extension views in the evaluation of cervicalspine<br />
injuries. Ann Emerg Med 20:117-121 [LoE 4]<br />
98. Link Tm, Schuierer G, Hufendiek A et al. (1995)<br />
Substantial head trauma: value of routine CT<br />
examination of the cervicocranium. Radiology<br />
196:741-745<br />
99. Link Tm, Schuierer G, Hufendiek A et al. (1994)<br />
HWS-Frakturen. Diagnostik bei polytraumatisierten<br />
Patienten. Radiologe 34:721-727 [LoE 5]<br />
100. Lomoschitz Fm, Blackmore Cc, Mirza Sk et al. (2002)<br />
Cervical spine injuries in patients 65 years old and<br />
older: epidemiologic analysis regarding the effects of<br />
age and injury mechanism on distribution, type, and<br />
stability of injuries. AJR Am J Roentgenol 178:573-<br />
577 [LoE 4]<br />
101. Lund Pj, Ruth Jt, Dzioba R et al. (1997) Traumatic<br />
thoracolumbar facet instability: characteristic imaging<br />
findings. Skeletal Radiol 26:360-365 [LoE 4]<br />
102. Macdonald Rl, Schwartz Ml, Mirich D et al. (1990)<br />
Diagnosis of cervical spine injury in motor vehicle<br />
crash victims: how many X-rays are enough? J<br />
Trauma 30:392-397 [LoE 4]<br />
103. Martin Rc, 2nd, Spain Da, Richardson Jd (2002) Do<br />
facial fractures protect the brain or are they a marker<br />
for severe head injury? Am Surg 68:477-481 [LoE 4]<br />
104. Mclain Rf, Benson Dr (1998) Missed cervical<br />
dissociation--recognizing and avoiding potential<br />
disaster. J Emerg Med 16:179-183 [LoE 4]<br />
105. Meldon Sw, Moettus Ln (1995) Thoracolumbar spine<br />
fractures: clinical presentation and the effect of altered<br />
sensorium and major injury. J Trauma 39:1110-1114<br />
[LoE 4]<br />
106. Metak G, Scherer Ma, Dannöhl C (1994) Übersehene<br />
Verletzungen des Stütz- und Bewegungsapparats beim<br />
<strong>Polytrauma</strong> - eine retrospektive Studie. Zentralbl Chir<br />
119:88-94 [LoE 4]<br />
107. Miller Cd, Blyth P, Civil Id (2000) Lumbar transverse<br />
process fractures--a sentinel marker of abdominal<br />
organ injuries. Injury 31:773-776<br />
108. Mirvis Se, Diaconis Jn, Chirico Pa et al. (1989)<br />
Protocol-driven radiologic evaluation of suspected<br />
cervical spine injury: efficacy study. Radiology<br />
170:831-834 [LoE 4]<br />
109. Morris Cg, Mccoy É (2004) Clearing the cervical<br />
spine in unconscious polytrauma victims, balancing<br />
risks and effective screening. Anaesthesia 59:464-482<br />
[LoE 5]<br />
110. Morris Cg, Mccoy Ep, Lavery Gg (2004) Spinal<br />
immobilisation for unconscious patients with multiple<br />
injuries. BMJ 329:495-499 [LoE 5]<br />
111. Mower Wr, Hoffman Jr, Pollack Cv, Jr. et al. (2001)<br />
Use of plain radiography to screen for cervical spine<br />
injuries. Ann Emerg Med 38:1-7 [LoE 4]<br />
112. Novelline Ra, Rhea Jt, Rao Pm et al. (1999) Helical<br />
CT in emergency radiology. Radiology 213:321-339<br />
[LoE 5]<br />
113. Nuñez Db, Jr., Zuluaga A, Fuentes-Bernardo Da et al.<br />
(1996) Cervical spine trauma: how much more do we<br />
learn by routinely using helical CT? Radiographics<br />
16:1307-1321<br />
114. Otani K, Abe H, Kadoya S et al. (1994) Beneficial<br />
effect of methylprednisolone sodium succinate in the<br />
treatment of acute spinal cord injury [In Japanese].<br />
Spine and Spinal Cord 7:633-647 [LoE 1b]<br />
115. Otte D, Sandor L, Zwipp H (1990) Bedeutung und<br />
Mechanismen von Brust- und<br />
Lendenwirbelsäulenverletzungen bei<br />
Verkehrsunfällen. Unfallchirurg 93:418-425 [LoE 4]<br />
116. Pal Jm, Mulder Ds, Brown Ra et al. (1988) Assessing<br />
multiple trauma: is the cervical spine enough? J<br />
Trauma 28:1282-1284 [LoE 4]<br />
117. Patten Rm, Gunberg Sr, Brandenburger Dk (2000)<br />
Frequency and importance of transverse process<br />
fractures in the lumbar vertebrae at helical abdominal<br />
CT in patients with trauma. Radiology 215:831-834<br />
118. Patton Jh, Kralovich Ka, Cuschieri J et al. (2000)<br />
Clearing the cervical spine in victims of blunt assault<br />
to the head and neck: what is necessary? Am Surg<br />
66:326-331 [LoE 4]<br />
119. Platzer P, Jaindl M, Thalhammer G et al. (2006)<br />
Clearing the cervical spine in critically injured<br />
patients: a comprehensive C-spine protocol to avoid<br />
unnecessary delays in diagnosis. Eur Spine J 15:1801-<br />
1810<br />
120. Pointillart V, Petitjean Me, Wiart L et al. (2000)<br />
Pharmacological therapy of spinal cord injury during<br />
the acute phase. Spinal Cord 38:71-76 [LoE 1b]<br />
121. Pollack Cv, Jr., Hendey Gw, Martin Dr et al. (2001)<br />
Use of flexion-extension radiographs of the cervical<br />
spine in blunt trauma. Ann Emerg Med 38:8-11 [LoE<br />
4]<br />
122. Prasad Vssv, Schwartz A, Bhutani R et al. (1999)<br />
Characteristics of injuries to the cervical spine and<br />
spinal cord in polytrauma patient population:<br />
experience from a regional trauma unit. Spinal Cord<br />
37:560-568 [LoE 4]<br />
123. Ptak T, Kihiczak D, Lawrason Jn et al. (2001)<br />
Screening for cervical spine trauma with helical CT:<br />
experience with 676 cases. Emerg Radiol 8:315-319<br />
[LoE 4]<br />
124. Qian T, Guo X, Levi Ad et al. (2004) High-dose<br />
methylprednisolone may cause myopathy in acute<br />
spinal cord injury patients. Spinal Cord [LoE 2b]<br />
125. Ralston Me, Ecklund K, Emans Jb et al. (2003) Role<br />
of oblique radiographs in blunt pediatric cervical<br />
spine injury. Pediatr Emerg Care 19:68-72 [LoE 4]<br />
126. Rhea Jt, Sheridan Rl, Mullins Me et al. (2001) Can<br />
chest and abdominal trauma CT eliminate the need for<br />
plain films of the spine? Experience with 329 multiple<br />
trauma patients. Emerg Radiol 8:99-104<br />
127. Rhee Kj, Green W, Holcroft Jw et al. (1990) Oral<br />
intubation in the multiply injured patient: the risk of<br />
exacerbating spinal cord damage. Ann Emerg Med<br />
19:511-514 [LoE 4]<br />
128. Roberge Rj, Wears Rc, Kelly M et al. (1988) Selective<br />
application of cervical spine radiography in alert<br />
victims of blunt trauma: a prospective study. J Trauma<br />
28:784-788 [LoE 4]<br />
Emergency room – Spine 237
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
129. Rogers Lf, Hendrix Rw (1990) Evaluating the<br />
multiply injured patient radiographically. Orthop Clin<br />
North Am 21:437-447 [LoE 4]<br />
130. Rokkanen P, Alho A, Avikainen V et al. (1974) The<br />
efficacy of corticosteroids in severe trauma. Surg<br />
Gynecol Obstet 138:69-73 [LoE 1b]<br />
131. Ross Se, O'malley Kf, Delong Wg et al. (1992)<br />
Clinical predictors of unstable cervical spinal injury in<br />
multiply injured patients. Injury 23:317-319 [LoE 4]<br />
132. Ruchholtz S, Nast-Kolb D, Waydhas C et al. (1996)<br />
Das Verletzungsmuster beim <strong>Polytrauma</strong>: Stellenwert<br />
der Information über den Unfallhergang zum<br />
Zeitpunkt der klinischen Akutversorgung.<br />
Unfallchirurg 99:633-641 [LoE 4]<br />
133. Ryan M, Klein S, Bongard F (1993) Missed injuries<br />
associated with spinal cord trauma. Am Surg 59:371-<br />
374 [LoE 4]<br />
134. Ryan Md, Henderson Jj (1992) The epidemiology of<br />
fractures and fracture-dislocations of the cervical<br />
spine. Injury 23:38-40 [LoE 4]<br />
135. Rybicki Fj, Knoll B, Mckenney K et al. (2000)<br />
Imaging of the cervical spine trauma: are the<br />
anterioposterior and odontoid radiographs needed<br />
when CT of the entire cervical spine is routine?<br />
Emerg Radiol 7:352-355 [LoE 4]<br />
136. Santora Ta, Kaplan Lj, Trooskin Sz (2001) Evaluation<br />
of the cervical spine. In: Sing RF, Reilly PM, Messick<br />
WJ (eds) Initial mangament of injuries: an evidence<br />
based approach. BMJ Books, London, p 20-30 [LoE<br />
5]<br />
137. Sauerland S, Nagelschmidt M, Mallmann P et al.<br />
(2000) Risks and benefits of preoperative high dose<br />
methylprednisolone in surgical patients: a systematic<br />
review. Drug Saf 23:449-461 [LoE 1a]<br />
138. Schandler Sl, Cohen Mj, Vulpe M et al. (1995)<br />
Incidence and characteristics of spinal cord injured<br />
patients with a family history of alcoholism. J Stud<br />
Alcohol 56:522-527 [LoE 3]<br />
139. Schenarts Pj, Diaz J, Kaiser C et al. (2001)<br />
Prospective comparison of admission computed<br />
tomographic scan and plain films of the upper cervical<br />
spine in trauma patients with altered mental status. J<br />
Trauma 51:663-669 [LoE 3b]<br />
140. Schleehauf K, Ross Se, Civil Id et al. (1989)<br />
Computed tomography in the initial evaluation of the<br />
cervical spine. Ann Emerg Med 18:815-817<br />
141. Schnarkowski P, Friedrich Jm, Arand M et al. (1991)<br />
Halswirbelsäulenverletzungen bei Schädel-Hirn-<br />
Trauma: Röntgendiagnostik am Unfalltag. Röfo<br />
Fortschr Röntgenstr 154:605-609<br />
142. Sees Dw, Rodriguez Cruz Lr, Flaherty Sf et al. (1998)<br />
The use of bedside fluoroscopy to evaluate the<br />
cervical spine in obtunded trauma patients. J Trauma<br />
45:768-771<br />
143. Shaffer Ma, Doris Pe (1981) Limitation of the cross<br />
table lateral view in detecting cervical spine injuries: a<br />
retrospective analysis. Ann Emerg Med 10:508-513<br />
[LoE 4]<br />
144. Shanmuganathan K, Mirvis Se, Levine Am (1994)<br />
Rotational injury of cervical facets: CT analysis of<br />
fracture patterns with implications for management<br />
and neurologic outcome. AJR Am J Roentgenol<br />
163:1165-1169 [LoE 4]<br />
145. Short D (2001) Is the role of steroids in acute spinal<br />
cord injury now resolved? Curr Opin Neurol 14:759-<br />
763 [LoE 5]<br />
146. Short Dj, El Masry Ws, Jones Pw (2000) High dose<br />
methylprednisolone in the management of acute spinal<br />
cord injury - a systematic review from a clinical<br />
perspective. Spinal Cord 38:273-286 [LoE 1a]<br />
147. Stabler A, Eck J, Penning R et al. (2001) Cervical<br />
spine: postmortem assessment of accident injuries-comparison<br />
of radiographic, MR imaging, anatomic,<br />
and pathologic findings. Radiology 221:340-346 [LoE<br />
4]<br />
148. Staedele Hg, Gross T, Jacob Al et al. (2003)<br />
Bildgebende Diagnostik bei der primären Abklärung<br />
polytraumatisierter Patienten. Aktuelle Traumatol<br />
33:148-156 [LoE 5]<br />
149. Stanislas Mj, Latham Jm, Porter Km et al. (1998) A<br />
high risk group for thoracolumbar fractures. Injury<br />
29:15-18 [LoE 4]<br />
150. Stiell Ig, Clement Cm, Mcknight Rd et al. (2003) The<br />
Canadian C-spine rule versus the NEXUS low-risk<br />
criteria in patients with trauma. N Engl J Med<br />
349:2510-2518 [LoE 1b]<br />
151. Stiell Ig, Wells Ga, Vandemheen Kl et al. (2001) The<br />
Canadian C-spine rule for radiography in alert and<br />
stable trauma patients. JAMA 286:1841-1848 [LoE<br />
1b]<br />
152. Streitwieser Dr, Knopp R, Wales Lr et al. (1983)<br />
Accuracy of standard radiographic views in detecting<br />
cervical spine fractures. Ann Emerg Med 12:538-542<br />
[LoE 3b]<br />
153. Suberviola B, Gonzalez-Castro A, Llorca J et al.<br />
(2008) Early complications of high-dose<br />
methylprednisolone in acute spinal cord injury<br />
patients. Injury 39:748-752<br />
154. Svennevig Jl, Bugge-Asperheim B, Vaage J et al.<br />
(1984) Corticosteroids in the treatment of blunt injury<br />
of the chest. Injury 16:80-84 [LoE 1b]<br />
155. Sweeney Jf, Rosemurgy As, Gill S et al. (1992) Is the<br />
cervical spine clear? Undetected cervical fractures<br />
diagnosed only at autopsy. Ann Emerg Med 21:1288-<br />
1290 [LoE 4]<br />
156. Tan E, Schweitzer Me, Vaccaro L et al. (1999) Is<br />
computed tomography of nonvisualized C7-T1 costeffective?<br />
J Spinal Disord 12:472-476<br />
157. Tehranzadeh J, Bonk Rt, Ansari A et al. (1994)<br />
Efficacy of limited CT for nonvisualized lower<br />
cervical spine in patients with blunt trauma. Skeletal<br />
Radiol 23:349-352 [LoE 4]<br />
158. Travlos A, Hirsch G (1993) Steroid psychosis: a cause<br />
of confusion on the acute spinal cord injury unit. Arch<br />
Phys Med Rehabil 74:312-315 [LoE 4]<br />
159. Ullrich A, Hendey Gw, Geiderman J et al. (2001)<br />
Distracting painful injuries associated with cervical<br />
spinal injuries in blunt trauma. Acad Emerg Med<br />
8:25-29 [LoE 4]<br />
160. Van Beek Ej, Been Hd, Ponsen Kk et al. (2000) Upper<br />
thoracic spinal fractures in trauma patients - a<br />
diagnostic pitfall. Injury 31:219-223 [LoE 4]<br />
Emergency room – Spine 238
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
161. Vickery D (2001) The use of the spinal board after the<br />
pre-hospital phase of trauma management. Emerg<br />
Med J 18:51-54 [LoE 4]<br />
162. West Oc, Anbari Mm, Pilgram Tk et al. (1997) Acute<br />
cervical spine trauma: diagnostic performance of<br />
single-view versus three-view radiographic screening.<br />
Radiology 204:819-823 [LoE 4]<br />
163. White P, Seymour R, Powell N (1999) MRI<br />
assessment of the pre-vertebral soft tissues in acute<br />
cervical spine trauma. Br J Radiol 72:818-823 [LoE 4]<br />
164. Widder S, Doig C, Burrowes P et al. (2004)<br />
Prospective evaluation of computed tomographic<br />
scanning for the spinal clearance of obtunded trauma<br />
patients: preliminary results. J Trauma 56:1179-1184<br />
165. Williams J, Jehle D, Cottington E et al. (1992) Head,<br />
facial, and clavicular trauma as a predictor of cervicalspine<br />
injury. Ann Emerg Med 21:719-722 [LoE 4]<br />
166. Winslow Je, 3rd, Hensberry R, Bozeman Wp et al.<br />
(2006) Risk of thoracolumbar fractures doubled in<br />
victims of motor vehicle collisions with cervical spine<br />
fractures. J Trauma 61:686-687 [LoE 5]<br />
167. Wintermark M, Mouhsine E, Theumann N et al.<br />
(2003) Thoracolumbar spine fractures in patients who<br />
have sustained severe trauma: depiction with multidetector<br />
row CT. Radiology 227:681-689<br />
168. Woodring Jh, Lee C (1993) Limitations of cervical<br />
radiography in the evaluation of acute cervical trauma.<br />
J Trauma 34:32-39<br />
169. Zabel Dd, Tinkoff G, Wittenborn W et al. (1997)<br />
Adequacy and efficacy of lateral cervical spine<br />
radiography in alert, high-risk blunt trauma patient. J<br />
Trauma 43:952-958 [LoE 4]<br />
Emergency room – Spine 239
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.10 Extremities<br />
The importance of evaluation and examination<br />
Even if there are no scientific studies on the importance and the necessary scope of the physical<br />
examination in the emergency room examination, it is still an indispensable requirement in<br />
identifying symptoms and in making (suspected) diagnoses. The systematic examination of the<br />
extremities of the undressed patient “in craniocaudal sequence” serves primarily to detect<br />
relevant, partially threatening injuries which can lead to a radiologic diagnostic study, immediate<br />
specific treatment and, in many cases, also a logistic decision taken while still in the emergency<br />
room [2, 14]. Its intended use is to estimate the overall injury severity.<br />
The examination in the region of the extremities consists of the detailed inspection and manual<br />
examination of the extremities for any type of external injury signs such as swelling, hematoma<br />
or wounds. Any closed or open soft tissue damage present is also classified. Definite fracture<br />
signs should be noted down. The systematic examination of the extremities allows fractures,<br />
dislocations, and dislocation fractures to be clinically detected or at least delimited. The stability<br />
test should be carried out on the large and small joints.<br />
The purport of the primary survey is also to distinguish a disorder in circulation, motor functions,<br />
and sensitivity. The possibility of compartment syndrome should be excluded. The neurologic<br />
finding for all extremities can only be collected from alert patients; otherwise, the reflex status<br />
must be checked as a minimum. It is essential for the treatment of extremity injuries to<br />
distinguish again between neurologic disorders in the central nervous system and those from<br />
peripheral causes.<br />
Missed injuries are also found retrospectively in the extremities region, particularly in<br />
unconscious and multiply injured patients. These injuries often require surgical management [3].<br />
The incidence of missed injuries is independent from any interruption in emergency room<br />
diagnosis due to emergency surgery.<br />
The examination of the extremities is sometimes neglected in an unstable patient and injuries are<br />
missed [4, 5]. Another source of error is the examiner-dependent evaluation of radiographs,<br />
which can be subject to a false interpretation [6, 7, 8].<br />
In this context, process optimization and monitored training [9], and the introduction of<br />
guidelines lead to an improvement in patient care [10]. However, missed injuries to the<br />
extremities are rarely life-threatening and, after the multiply injured have been stabilized, can<br />
often be diagnosed in the secondary survey and surgically managed [32].<br />
Emergency room – Extremities 240
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Diagnostic equipment<br />
Key recommendations:<br />
If there are confirmed or unconfirmed fracture signs, extremity findings<br />
should be assessed depending on the patient’s condition using a suitable<br />
radiologic procedure (plain radiograph in 2 planes or CT).<br />
The radiologic diagnostic study should be performed at the earliest possible<br />
opportunity.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
The l<strong>eng</strong>th of stay in the emergency room affects the treatment results and the morbidity/case<br />
fatality rate of a severely injured patient [10]. There is no absolute value to adhere to such as the<br />
“golden hour”, for example [11].<br />
In certain regions, the scope of diagnostic radiology can be limited by the confirmed clinical<br />
examination. For example, without weight-bearing pain, effusion or hematoma, a fracture has<br />
been excluded in knee injuries (as monotrauma) [12].<br />
A lateral radiograph is sufficient for specific screening of a knee fracture. It is 100% sensitive<br />
[13].<br />
If a bony extremity injury is clinically suspected in stable patients, a radiograph should be taken<br />
in at least 2 planes. Deliberately dispensing with the radiologic visualization is only justifiable if<br />
the emergency room diagnostic tests are interrupted due to emergency surgery [14].<br />
Studies on l<strong>eng</strong>th of stay in the emergency room and on treatment results specifically on<br />
extremity injuries are not known. There are also no studies on the issue of whether a deliberate<br />
postponement of diagnostic radiology on extremity injuries to shorten the emergency room phase<br />
affects the treatment results of the injured.<br />
There are several scientific studies with a poor outcome on the delayed management of injuries<br />
to the extremities. However, they are not considered in conjunction with a postponement in the<br />
emergency room diagnostic tests.<br />
Emergency room – Extremities 241
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Diagnostic study/Treatment<br />
Should obvious malpositions in the extremities be reduced?<br />
Key recommendations:<br />
Malpositions and dislocations in the extremities should be reduced and<br />
stabilized.<br />
GoR B<br />
The reduction outcome should not be altered through other interventions. GoR B<br />
Explanation:<br />
An injured extremity that has been correctly immobilized by the emergency services should be<br />
left alone in the emergency room until definitive care. Any alteration in immobilization in the<br />
actual injury area can potentially lead to a worsening in soft tissue damage and pain reactions,<br />
particularly in bony unstable conditions [15]. A reliable interface with the emergency services<br />
avoids unnecessary repositioning. To date, there have been no scientific studies on whether<br />
repositioning measures in the emergency room affect the extremity injury.<br />
With the prehospital care of the injured by an emergency services system, it can be assumed that<br />
extremity injuries are immobilized in the neutral position. If this immobilization is correctly<br />
performed, repositioning measures of the whole patient have virtually no effect on the individual<br />
injury to the extremities. If immobilization is correctly performed, removing/altering the<br />
immobilization of an extremity is unnecessary until in the operating room.<br />
Lack of pulse after a prehospital fracture reduction has not been described in the literature up till<br />
now.<br />
Open fractures<br />
Key recommendations:<br />
If sufficiently reliable information has been provided by the emergency<br />
services, a sterile emergency dressing should be left in place until entry to the<br />
operating room.<br />
Explanation:<br />
GoR B<br />
In the emergency room, open fractures should be managed according to the basic principles of<br />
aseptic wound management. In principle, open fractures are a surgical emergency, requiring<br />
immediate surgery. The decisive factors for a possible infection lie outside the emergency room:<br />
for infectiologic reasons, do not repeatedly open. This is because resistant hospital germs are<br />
more dangerous than the germs collected at the accident scene. A direct correlation between<br />
frequency of infection and exposure could not be proven by Merritt [35, 36].<br />
Emergency room – Extremities 242
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Pulseless extremity<br />
Key recommendations:<br />
If there is no peripheral pulse (Doppler/palpation) in an extremity, further<br />
diagnostic tests should be carried out.<br />
Depending on the finding and condition of the patient, conventional arterial<br />
digital subtraction angiography (DSA), duplex ultrasonography or angio-CT<br />
(CTA) should be performed.<br />
Intraoperative angiography should be given priority in vascular injuries to the<br />
extremities that were not diagnosed in the emergency room in order to shorten<br />
the period of ischemia.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
GoR B<br />
Compared to the sensitivity of the other diagnostic equipment, the duplex ultrasonography<br />
examination is at least equivalent to invasive arteriography [19]. Good results from<br />
ultrasonography are to a large extent dependent on the examiner [20. 21].<br />
The period of ischemia is crucial for the prognosis of the extremity as well as the whole body. A<br />
quick diagnosis with localization of potential injuries is essential to then enable rapid surgical<br />
management.<br />
The diagnosis of a vascular lesion cannot be made solely on the basis of the clinical examination.<br />
Vascular injuries require a rapid, definite emergency room diagnostic study. Depending on the<br />
examiner, the duplex ultrasound examination best fulfills the above requirements. If there is<br />
already a clear clinical indication for surgery, preference should be given to intraoperative<br />
angiography over the emergency room diagnostic tests. Here, as in the above-mentioned studies<br />
on ultrasonography, the hospital structure plays a considerable role so that a generally valid<br />
recommendation can only be made with reservations.<br />
More recent papers show that preference should be given to CT angiography over conventional<br />
arterial digital subtraction angiography (DSA) in appropriately stable patients. The procedure of<br />
computed tomography angiography (CTA) takes up markedly less time and is also cheaper [31].<br />
It is less invasive than DSA and the rapid development in technology now permits visualization<br />
of all arteries in a short time. However, its value is limited by the large quantity of iodinated<br />
contrast agent and the high radiation exposure. Calcified plaques also compromise the detailed<br />
visualization of medium and small arteries (33, 34). The extent of ischemia in peripheral<br />
extremities depends on the localization and l<strong>eng</strong>th of the vascular obstruction as well as on the<br />
possible presence of developed collaterals. In a healthy vascular system, even a short l<strong>eng</strong>th of<br />
obstruction or an isolated break in an extremity artery can lead to necrosis of the dependent<br />
musculature.<br />
Emergency room – Extremities 243
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The tolerated ischemia period is shorter the healthier the vascular system.<br />
In polytrauma, there is the added difficulty that the injury to the extremity triggers arterial<br />
vascular spasms, which themselves entail a marked decrease in blood flow to the extremity [22].<br />
If there is insufficient blood flow to the peripheral muscle tissue after 3 hours, the risk of<br />
compartment syndrome following revascularization must be taken in to account. Very<br />
pronounced direct soft tissue trauma can worsen the prognosis of revascularization.<br />
Compartment syndrome<br />
Key recommendation:<br />
If there is suspected compartment syndrome, the invasive compartment<br />
pressure measurement can be used in the emergency room.<br />
Explanation:<br />
GoR 0<br />
Compartment syndrome is a time-dependent noxious agent and can develop dynamically. It<br />
arises from an increase in intrafascial pressure in the compartments. It can affect all regions of<br />
the extremities, primarily the ankle. Burns and positioning damage as well as injuries are also<br />
part of the etiology. In the clinical examination, there are many compartment signs which are<br />
nevertheless not all evidentiary: pain, intensified through passive exertion of the muscle part<br />
involved, swelling of the muscle part involved, sensitivity disorders in the muscle dermatome.<br />
In a suspected diagnosis, based on the above-mentioned clinical signs, the intrafascial pressure is<br />
measured objectively without delay, if applicable as the baseline value in the emergency room. It<br />
is advantageous to carry out continuous pressure measurements. A diastolic blood pressure in<br />
mmHg minus the compartment measurement value in mmHg less than 30 mmHg is given as the<br />
pathologic value [23, 24].<br />
Particularly in polytrauma, the onset of compartment syndrome must be taken into account in<br />
massive infusion and massive transfusion. The possibility of clinically assessing a threatening or<br />
manifest compartment syndrome is often inadequate in anesthetized patients so that only the<br />
blood measurement of the intrafascial pressure permits an indicatory statement. It must be noted<br />
here that the accuracy of the compartment pressure measurement depends on the examiner and<br />
can be false-positive/negative.<br />
Amputation injuries<br />
In the multiply injured, the meaningfulness of attempting to salvage the extremity needs to be<br />
discussed for soft tissue damage grade 3 of closed and grade 4 of open fractures. Particularly in<br />
the multiply injured patient, it must be taken into account that a protracted salvage attempt with<br />
long surgery times can endanger the patient’s vital functions.<br />
Emergency room – Extremities 244
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The decision to attempt to salvage an injured extremity is advisable only after the primary survey<br />
according to ATLS ® and ETC has been completed. Only then can the complete injury pattern be<br />
evaluated with regard to a stable patient for extended surgical management.<br />
On the other hand, from experience, the indication for attempting to salvage an extremity should<br />
only be made by a competent surgeon after a detailed inspection of the injured soft tissue. This<br />
can only be done in the operating room.<br />
Thus, emergency completion of a subtotal amputation on an unstable patient in the emergency<br />
room remains an unresolved issue. These are case-by-case decisions, which depend more on the<br />
remainder of the injury pattern and less on the extremity finding. There are many case histories<br />
to be found on this topic in the literature, such as successful reconstructions or replantation of<br />
extremities. It is not possible to conclude recommendations. It appears unrealistic to conduct a<br />
study.<br />
In the case of open extremity injuries, a decision should be taken in the emergency room on the<br />
operability in relation to the expected operating time to salvage the extremity in the multiply<br />
injured patient.<br />
An emergency completion of an amputation in the emergency room remains subject to the<br />
unstable patient and requires an individual decision from the trauma surgery team leader.<br />
CT diagnostic test<br />
The use of computed tomography (CT) in emergency room diagnostic tests primarily concerns<br />
torso injuries including pelvic fractures. Ultimately, the CT diagnostic test in emergency room<br />
management is being increasingly preferred over conventional diagnostic radiology of the<br />
extremities because of structural measures and ongoing software development.<br />
Whether this allows conventional diagnostic radiology to be dispensed with can only be decided<br />
on a case-by-case basis at present. A generally valid recommendation is not possible. In a<br />
retrospective study, Wurmb et al showed that, in a comparative patient collective of a first group<br />
of 82 patients who received a complete CT work-up of their injuries and a second group of 79<br />
patients who first received conventional conservative diagnostic radiology and then a focused<br />
CT scan, there was a time saving of 23 minutes versus 70 minutes in the second group [27].<br />
However, Ruchholtz et al. in their study highlight missed injuries in the CT as well and also cite<br />
the increased radiation exposure [28].<br />
A CT diagnostic test can be performed after conventional diagnostic radiology in the emergency<br />
room on a stable patient with a suspected talus or scaphoid fracture in order to plan surgery and<br />
so as not to miss fractures in this region [29, 30].<br />
Emergency room – Extremities 245
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Sackett, D.L., et al., Evidence-based medicine: How<br />
to practice and teach EBM. 1997, London: Churchill<br />
Livingstone.<br />
2. Tscherne H, Regel G. Care of the polytraumatised<br />
patient. J Bone Joint Surg Br. 1996.78(5):840-5 [LoE<br />
3a]<br />
3. Enderson BL, Reath DB, Meadors J, Dallas W,<br />
DeBoo JM, Maull KI. The tertiary trauma survey: a<br />
prospective study of missed injury. J Trauma. 1990<br />
30(6):666-9 [LoE 3b]<br />
4. McLaren CA, Robertson C, Little K. Missed<br />
orthopaedic injuries in the resuscitation room. J R<br />
Coll Surg Edinb. 1983 28(6):399-401<br />
5. Born CT, Ross SE, Iannacone WM, Schwab CW,<br />
DeLong WG. Delayed identification of skeletal injury<br />
in multisystem trauma: the 'missed' fracture. J<br />
Trauma. 1989 29(12):1643-6 [LoE 3b]<br />
6. Laasonen EM, Kivioja A. Delayed diagnosis of<br />
extremity injuries in patients with multiple injuries. J<br />
Trauma. 1991 31(2):257-60 [LoE 3b]<br />
7. Metak G, Scherer MA, Dannöhl C. Missed injuries<br />
of the musculoskeletal system in multiple trauma--a<br />
retrospective study Zentralbl Chir. 1994 119(2):88-94<br />
[LoE 3b]<br />
8. Kremli MK Missed musculoskeletal injuries in a<br />
University Hospital in Riyadh: types of missed<br />
injuries and responsible factors.Injury. 1996<br />
27(7):503-6 [LoE 3b]<br />
9. Hoyt DB, Shackford SR, Fridland PH, Mackersie RC,<br />
Hansbrough JF, Wachtel TL, Fortune JB Video<br />
recording trauma resuscitations: an effective teaching<br />
technique. J Trauma. 1988 28(4):435-40 [LoE 3b]<br />
10. Ruchholtz S, Zintl B, Nast-Kolb D, Waydhas C,<br />
Schwender D, Pfeifer KJ, Schweiberer L. Quality<br />
management in early clinical polytrauma<br />
management. II. Optimizing therapy by treatment<br />
guidelines Unfallchirurg. 1997 100(11):859-66<br />
[Evidenzbasierte Leitlinie]<br />
11. Lerner EB, Moscati RM The golden hour: scientific<br />
fact or medical "urban legend"? Acad Emerg Med<br />
2001; 8(7): 758-60 [LoE 3a]<br />
12. Bauer SJ, Hollander JE, Fuchs SH, Thode HC A<br />
clinical decision rule in the evaluation of acute knee<br />
injuries. The Journal of Emerg. Med. 1995 13/5:611-<br />
615 [LoE 1b]<br />
13. Verma A, Su A, Golin AM, O`Marrah B, Amorosa JK<br />
(2001) The Lateral View. Acad Radiol 8:392-397<br />
[LoE 3b]<br />
14. American College of Surgeons Advanced Trauma<br />
Life Support (Chicago) 1997<br />
15. Beck A, Gebhard F, Kinzl L, Strecker W. Principles<br />
and techniques of primary trauma surgery<br />
management at the site Unfallchirurg. 2001<br />
104(11):1082-96 [LoE 3a]<br />
16. Willett KM, Dorrell H, Kelly P ABC of major trauma.<br />
Management of limb injuries BMJ. 1990<br />
28;301(6745):229-33 [LoE 3b]<br />
17. Schlickewei W, Kuner EH, Mullaji AB, Gotze B<br />
Upper and lower limb fractures with concomitant<br />
arterial injury. J Bone Joint Surg Br 1992 74(2): 181-8<br />
[LoE 3b]<br />
18. Vollmar J Bone fracture and vascular lesion (author's<br />
transl) Langenbecks Arch Chir. 1975 339:473-7 [LoE<br />
5]<br />
19. Ruppert, V., M. Sadeghi-Azandaryani, et al..Vascular<br />
injuries in extremities. Chirurg 2004 75(12): 1229-38<br />
[LoE 3a]<br />
20. Panetta TF, Hunt JP, Buechter KJ, Pottmeyer A, Batti<br />
JS (1992) Duplex Ultrasonography versus<br />
arteriography in the diagnosis of arterial injury: an<br />
experimental study. J Trauma 33:627-636 [LoE 1b]<br />
21. Kuzniec S, Kauffmann P, Molnár LJ, Aun R, Puech-<br />
Leão P Diagnosis of limbs and neck arterial trauma<br />
using duplex ultrasonography. Cardiovascular Surgery<br />
1998 6/4:358-366 [LoE 3b]<br />
22. Glass GE, Pearse MF, Nanchahal J. Improving lower<br />
limb salvage following fractures with vascular injury:<br />
a systematic review and new management algorithm. J<br />
Plast Reconstr Aesthet Surg. 2009 62(5):571-9 [LoE<br />
3a]<br />
23. Elliott KGB, Johnstone AJ Diagnosting acute<br />
compartment syndrome. J Bone Joint Surg 2003 85-<br />
B:625-32 [LoE 3b]<br />
24. Kosir R, Moore FA, Selby JH, Cocanour CS, Kozar<br />
RA, Gonzalez EA, Todd SR Acute lower extremity<br />
compartment syndrome (ALECS) screening protocol<br />
in critically ill trauma patients. J Trauma. 2007<br />
63(2):268-75 [LoE 3b]<br />
25. Aufmkolk M, Dominguez E, Letsch R, Neudeck F,<br />
Niebel W. Results of peripheral arterial vascular<br />
injury in polytraumatized patients Unfallchirurg 1996.<br />
99(8):555-60 [LoE 4]<br />
26. Leidner B, Adiels M, Aspelin P, Gullstrand P, Wallen<br />
S Standardized CT examination of the<br />
multitraumatized patient. Eur Radiol 1998; 8(9):<br />
1630-8 [LoE 3b]<br />
27. Wurmb, T. E., P. Fruhwald, et al.Whole-body<br />
multislice computed tomography as the first line<br />
diagnostic tool in patients with multiple injuries: the<br />
focus on time. J Trauma 2009 66(3): 658-65 [LoE 3b]<br />
28. Ruchholtz S, Waydhas C, Schroeder T, Piepenbrink<br />
K, Kuhl H, Nast-Kolb D The value of computed<br />
tomography in the early treatment of seriously injured<br />
patients. Chirurg 2002; 73(10): 1005-12 [LoE 3b]<br />
29. Blum, A., B. Sauer, et al. The diagnosis of recent<br />
scaphoid fractures: review of the literature. J Radiol<br />
2007 88(5 Pt 2): 741-59 [LoE 3a]<br />
30. Boack, D. H., S. Manegold, et al.Treatment strategy<br />
for talus fractures. Unfallchirurg 2004 107(6): 499-<br />
514 [LoE 3a]<br />
31. Seamon MJ, Smoger D, et al. A prospective validation<br />
of a current practice: the detection of extremity<br />
vascular injury with CT angiography. J Trauma. 2009<br />
67(2):238-43 [LoE 2b]<br />
32. Pehle B, Kuehne CA, et. al. The significance of<br />
delayed diagnosis of lesions in multiply traumatised<br />
patients. A study of 1,187 shock room patients.<br />
Unfallchirurg. 2006 109(11):964-74<br />
Emergency room – Extremities 246
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
33. Jakobs TE, Wintersperger BJ, Becker CR: MDCTimaging<br />
of peripheral arterial disease. Semin<br />
Ultrasound CT MR 2004 25(2):145-155<br />
34. Ota H, Takase K, Igrashi K, Chiba Y, Haga K, Saito<br />
H et al: MDCT compared with digital subtraction<br />
angiography for assessment of lower extremity arterial<br />
occlusive disease: importaance of reviewing crosssectional<br />
images. AJR Am J Roentgenol 2004 182<br />
(1):201-209<br />
35. Merritt K: Factors increasing the Risk of infection in<br />
patients with open fractures. J Trauma 1988 28:823-<br />
827<br />
36. Rojczyk M: Keimbesiedlung und Keimverhalten bei<br />
offenen Frakturen. Unfallheilkunde 1981 84: 458-462<br />
37. Barnes CJ, Pietrobon R, Higgins LD: Does the pulse<br />
examination in patients with traumatic knee<br />
dislocation predict a surgical aterial injury? A metaanalysis.<br />
J Trauma 2002 53: 1109-1114<br />
Emergency room – Extremities 247
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.11 Hand<br />
There are no studies above a Level of Evidence 4 on the diagnostic tests and surgical treatment<br />
for hand injuries, particularly in polytrauma. The available literature describes only injury<br />
frequencies and combinations. Recommendations on diagnosis and treatment methods exist only<br />
in the form of expert opinions. The following evidence-based recommendations must therefore<br />
be based on studies in which monotrauma in the hand have been studied.<br />
Hand injuries, especially fractures, can occur in up to 25% of cases of multiply injured patients<br />
[1, 12, 15, 18]. The most common injury here involves fractures of the hand skeleton including<br />
the distal radius; the latter occurs in 2-16% of all multiply injured patients [1, 4, 10, 13, 19].<br />
Tendon and nerve injuries are less common at 2-11% and 1.5%, respectively [15]. Amputations<br />
to the hand occur in only 0.2-3% of polytrauma cases [3, 11]. Severe combination hand injuries<br />
are also seldom found in polytrauma [17].<br />
Primary diagnosis<br />
Key recommendation:<br />
The clinical evaluation of the hands should be carried out during the basic<br />
diagnostic work-up as it is crucial for establishing the indication for carrying<br />
out further examinations requiring the use of equipment.<br />
Explanation:<br />
GoR B<br />
The probability of the occurrence of a hand injury does not depend on the severity of the<br />
polytrauma. In addition, it cannot be assumed that the probability for missing a hand injury<br />
increases with the injury severity [15]. However, primary missed and untreated hand injuries can<br />
later lead to considerable function impairments [8]. During the emergency diagnostic study,<br />
closed tendon injuries (tractus intermedius, distal extensor tendon, avulsion of deep flexor<br />
tendon), carpal fractures, and dislocations are frequently missed [6, 9, 16]. The clinical basic<br />
diagnostic work-up should comprise the examination for skin damage, swelling, hematoma,<br />
abnormal position and mobility, and monitoring perfusion (radial and ulnar arteries, capillary<br />
refill in finger pads) [17].<br />
Emergency room – Hand 248
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
If there is clinical suspicion of a hand injury, basic radiologic work-up should<br />
consist of a radiographic examination of the hand and wrist on 2 standard<br />
planes for each.<br />
Explanation:<br />
GoR B<br />
Radiographs of the hand and wrist should be taken on 2 planes in unconscious patients with<br />
clinical evidence of a hand injury (see above). Special attention should be paid to the possible<br />
presence of carpal fractures and dislocations. If there is clinical evidence of phalangeal fractures<br />
and if radiographs of the full hand cannot definitely exclude these or define them in a clear<br />
morphologic way, particularly in the case of a series fracture of several digits, it is advisable to<br />
radiograph the injured digit in isolation on 2 planes at the earliest possible opportunity [16, 17].<br />
Key recommendation:<br />
If there is clinical suspicion of an arterial vascular injury, Doppler or duplex<br />
ultrasonography should be performed.<br />
Explanation:<br />
GoR B<br />
If there is clinical suspicion of an arterial vascular injury, a rapid, accurate diagnosis can be<br />
made by Doppler or duplex examination [5, 7, 14]. In the remaining unclear cases with urgent<br />
clinical suspicion of an arterial injury, angiography is only indicated if the general condition of<br />
the patient forbids surgical exploration [7] or the localization of the lesion is uncertain [2]. The<br />
Allen test permits definite confirmation of the patency of the arterial radio-ulnar link and the two<br />
forearm arteries [5].<br />
Emergency room – Hand 249
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Aldrian, S., T. Nau, et al. (2005) [Hand injury in<br />
polytrauma] Wien Med Wochenschr 155(9-10): 227-<br />
32 [LoE 4]<br />
2. Bongard FS, White GH, Klein SR. (1989)<br />
Management strategy of complex extremity injuries.<br />
Am J Surg. Aug;158(2):151-5 [LoE 4]<br />
3. Brenner P, Reichert B, Berger A. (1995)<br />
Replantation bei Mehrfachverletzungen ? Handchir<br />
Mikrochir Plast Chir. Jan;27(1):12-6 [LoE 4]<br />
4. Dittel KK, Weller S. (1981) Zur Problematik des<br />
polytraumatisierten Patienten. Akt Traumatol 11: 35-<br />
42 [LoE 4]<br />
5. Gelberman RH, Menon J, Fronek A. (1980) The<br />
peripheral pulse following arterial injury. J Trauma.<br />
Nov;20(11):948-51 [LoE 4]<br />
6. Herzberg G, Comtet JJ, Linscheid RL, Amadio PC,<br />
Cooney WP, Stalder J. (1993) Perilunate dislocations<br />
and fracture-dislocations: a multicenter study. J Hand<br />
Surg [Am]. Sep;18(5):768-79 [LoE 2b]<br />
7. Koman LA, Ruch DS, Smith BP, Smith TL (1999)<br />
Vascular disorders. In Green DP, Hotchkiss RN,<br />
Pederson WC (Hrsg.): Operative Hand Surgery.<br />
Churchill Livingstone, New York, Edinburgh,<br />
London, Melbourne, Tokyo [LoE 2a]<br />
8. Mark G. (1989) Das Schicksal des polytraumatisierten<br />
Patienten mit einer "Bagatellverletzung" an der Hand.<br />
Handchir Mikrochir Plast Chir. Jan;21(1):51-4 [LoE<br />
5]<br />
9. Moore MN (1988) Orthopedic pitfalls in emergency<br />
medicine. South Med J; 81(3): 371-8 [LoE 5]<br />
10. Nast-Kolb D, Keßler S, Duswald KH, Betz A,<br />
Schweiberer L (1986) Extremtitätenverletzungen<br />
polytraumatisierter Patienten: stuf<strong>eng</strong>erechte<br />
Behandlung. Unfallchirurg 89 (1986), 149-154 [LoE<br />
4]<br />
11. Partington MT, Lineaweaver WC, O'Hara M,<br />
Kitzmiller J, Valauri FA, Oliva A, Buncke GM,<br />
Alpert BS, Siko PP, Buncke HJ (1993) Unrecognized<br />
injuries in patients referred for emergency<br />
microsurgery. J Trauma 34 238-241 [LoE 4]<br />
12. Regel G, Seekamp A, Takacs J, Bauch S, Sturm JA,<br />
Tscherne H. (1993) Rehabilitation und Reintregration<br />
polytraumatisierter Patienten. Unfallchirurg 96 341-<br />
349 [LoE 4]<br />
13. Reynolds BM, Balsano NA, Reynolds FX. Fall from<br />
heights: A surgical experience of 200 consecutive<br />
cases. Ann Surg 174 (1971), 304-308 [LoE 4]<br />
14. Rothkopf DM, Chu B, Gonzalez F, Borah G,<br />
Ashmead D 4th, Dunn R. (1993) Radial and ulnar<br />
artery repairs: assessing patency rates with color<br />
Doppler ultrasonographic imaging. J Hand Surg.<br />
18(4):626-8 [LoE 4]<br />
15. Schaller P, Geldmacher J (1994) Die Handverletzung<br />
beim <strong>Polytrauma</strong>. Eine retrospektive Studie an 728<br />
Fällen. Handchir Mikrochir Plast Chir 26 307-312<br />
[LoE 4]<br />
16. Skroudies B, Wening VJ, Jungbluth KH (1989)<br />
Perilunäre Luxationen und Luxationsfrakturen beim<br />
<strong>Polytrauma</strong>tisierten – Diagnostik und Therapie.<br />
Unfallchirurgie 15 236-242 [LoE 4]<br />
17. Spier W. (1971) Die Handverletzung bei<br />
Mehrfachverletzten. Med Welt 22, 169-172 [LoE 5]<br />
18. Vossoughi, F., B. Krantz, et al. (2007). Hand injuries<br />
as an indicator of other associated severe injuries. Am<br />
Surg 73(7): 706-8 [LoE 4]<br />
19. Welkerling H, Wening JV, Langendorff HU, Jungbluth<br />
KH. (1991) Computergestützte Datenanalyse von<br />
Verletzten des knöchernen Bewegungsapparates beim<br />
polytraumatisierten Patienten. Zbl Chir 116 1263-<br />
1272 [LoE 4]<br />
Emergency room – Hand 250
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.12 Foot<br />
Diagnostic study of foot injuries<br />
In the unconscious multiply injured patient, foot injuries can be excluded by repeated clinical<br />
examinations. Foot injuries are initially missed with an above average frequency in multiply<br />
injured patients. The reasons for this are more eye-catching and life-threatening injuries,<br />
deficient radiography technique in the emergency situation, extremely variable clinical<br />
standards, lack of experience on the part of the examiner with to some extent low case numbers<br />
of different foot injuries, and breakdown in communication in the treatment of the multiply<br />
injured by several teams [4–6, 9, 11, 16]. In the unconscious patient, repeated clinical<br />
examinations are thus necessary in the case of partially subtle injury signs in order not to miss<br />
foot injuries with potentially serious late complications [6, 17]. In a retrospective analysis, Metak<br />
et al. [9] found that 50% of all missed injuries to the lower extremities related to the foot and<br />
recommended a thorough clinical examination every 24 hours. If foot injuries are clinically<br />
suspected, radiography follow-up in the standardized settings (see below) is initially indicated<br />
and, if this does not provide adequate clarification, then stress views and a foot CT.<br />
Standard projections on the foot (review in [16, 17]):<br />
� Pilon, ankle joint ankle joint ┴<br />
� Talus ankle joint ┴, foot dorsoplantar (beam tilted 30 ° in craniocaudal<br />
direction)<br />
� Calcaneus calcaneus lateral, axial, foot dorsoplantar (beam tilted 30 ° in<br />
craniocaudal direction)<br />
� Chopart/Lisfranc foot true lateral, foot dorsoplantar (beams for Chopart tilted 30 °,<br />
for Lisfranc tilted 20 ° in caudocranial direction), 45 ° oblique view<br />
midfoot<br />
� Midfoot/toes mid/forefoot a. p., 45 ° oblique views, true lateral<br />
The occurrence of tension blisters on the foot must also be taken as an indicator for ischemic<br />
damage to the skin [10]. Besides clinical criteria, Doppler ultrasonography is recommended for<br />
the initial assessment of the vascular status of the foot [2, 12]. Controversy surrounds routine<br />
angiography where there is no Doppler signal [13] but it is indicated if the goal is for more<br />
complex reconstructions [7]. An important indicator for skin nutrition is the ankle brachial<br />
index. If the Doppler flow detects at least 50% of the brachial artery value, the wound healing<br />
rate is 90% [14]. The same was confirmed for transcutaneously measured oxygen tension<br />
exceeding 30 mmHg [15]. Poorer healing rates after surgical interventions can be expected in<br />
elderly persons (peripheral arterial obstructive disease [pAOD]), in diabetics, and in smokers [1,<br />
3, 8].<br />
Emergency room – Foot 251
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Abidi, NA et al. (1998) Wound-healing risk<br />
factors after open reduction and internal fixation<br />
of calcaneal fractures. Foot Ankle Int, 19: 856-<br />
61 [LoE 4]<br />
2. Attinger C (1995) The use of skin grafts in the<br />
foot. J Am Podiatr Med Assoc 85: 49-56 [LoE 4]<br />
3. Folk JW, Starr AJ, Early JS (1999) Early wound<br />
complications of operative treatment of<br />
calcaneus fractures: analysis of 190 fractures. J<br />
Orthop Trauma 13: 369-372 [LoE 4]<br />
4. Haapamaki V, Kiuru M, Koskinen S (2004)<br />
Lisfranc fracture-dislocation in patients with<br />
multiple trauma: diagnosis with multidetector<br />
computed tomography. Foot Ankle Int 25: 614-<br />
619 [LoE 4]<br />
5. Kremli MK (1996) Missed musculoskeletal<br />
injuries in a University Hospital in Riyadh: types<br />
of missed injuries and responsible factors. Injury<br />
27: 503-506 [LoE 4]<br />
6. Kotter A, Wieberneit J, Braun W, Ruter A<br />
(1997) Die Chopart-Luxation. Eine häufig<br />
unterschätzte Verletzung und ihre Folgen. Eine<br />
klinische Studie. Unfallchirurg 100: 737-741<br />
[LoE 4]<br />
7. Levin LS, Nunley JA (1993) The management<br />
of soft tissue problems associated with calcaneal<br />
fractures. Clin Orthop 290: 151-160 [LoE 4]<br />
8. McCormack RG, Leith JM (1998) Ankle<br />
fractures in diabetics. Complications of surgical<br />
management. J Bone Joint Surg Br 80: 689-692<br />
[LoE 4]<br />
9. Metak G, Scherer MA, Dannohl C (1994)<br />
Übersehene Verletzungen des Stütz- und<br />
Bewegungsapparates beim <strong>Polytrauma</strong> – eine<br />
retrospective Studie. Zentralbl Chir 119: 88-94<br />
[LoE 4]<br />
10. Peterson WC, Sanders WE (1996) Principles of<br />
fractures and dislocations. In: Rockwood CA,<br />
Green DP, Bucholz RW eds) Fractures in<br />
adults. J B Lippincott, Philadelphia, 365-368<br />
[LoE 5]<br />
11. Rammelt S, Biewener A, Grass R, Zwipp H<br />
(2005) Verletzungen des Fußes beim<br />
polytraumatisierten Patienten. Unfallchirurg<br />
108: 858-865 [LoE 5]<br />
12. Sanders LJ (1987) Amputations in the diabetic<br />
foot. Clin Podiatr Med Surg 4: 481-501 [LoE 4]<br />
13. Shah DM, Corson JD, Karmody AM, Fortune<br />
JB, Leather RP (1988) Optimal management of<br />
tibial arterial trauma. J Trauma 28: 228-234<br />
[LoE 4]<br />
14. Wagner FW (1979) Transcutaneous Doppler<br />
ultrasound in the prediction of healing and the<br />
selection of surgical level for dysvascular lesions<br />
of the toes and forefoot. Clin Orthop: 110-114<br />
[LoE 3]<br />
15. Wyss CR, Harrington RM, Burgess EM, Matsen<br />
FA, 3rd (1988) Transcutaneous oxygen tension<br />
as a predictor of success after an amputation. J<br />
Bone Joint Surg Am 70: 203-207 [LoE 3]<br />
16. Zwipp H (1994) Chirurgie des Fußes. Springer-<br />
Verlag, Wien - New York [LoE 5]<br />
17. Zwipp H, Rammelt S (2002) Frakturen und<br />
Luxationen. In: Wirth CJ, Zichner, L. (Hrsg.):<br />
Orthopädie und Orthopädische Chirurgie. Vol. 8.<br />
Georg Thieme Verlag, Stuttgart, New York,<br />
531-618 [LoE 5]<br />
Emergency room – Foot 252
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.13 Mandible and midface<br />
The frequency of injuries to the mandible and midface in multiply injured patients is about 18%<br />
[2, 19].<br />
The most common concomitant injuries in craniofacial fractures are cerebral hematomas at over<br />
40% followed by pulmonary contusions at over 30% [1].<br />
Examination<br />
Key recommendation:<br />
Functional and esthetic injuries should be excluded in the clinical examination<br />
of the head-neck region in multiply injured patients.<br />
Explanation:<br />
GoR B<br />
Calling on qualified specialists (maxillofacial specialists/otorhinolaryngologists, depending on<br />
availability or in-house arrangement) is considered advisable for all patients with evidence of<br />
mandible and maxillofacial injuries, even if this naturally depends on the qualifications of the<br />
physicians involved and the physical and organizational conditions [12, 15, 22].<br />
The examination should comprise a thorough inspection and palpation [3, 7]. It serves inter alia<br />
to confirm external and internal injuries (e.g., bruising, hematomas, abrasions, soft tissue<br />
injuries, bleeding, tooth injuries, eye injuries, cerebrospinal fluid leak, intracranial leak, and<br />
mandible and maxillofacial fractures).<br />
Diagnostic study<br />
Key recommendation:<br />
If there is clinical evidence of mandible and maxillofacial injuries, further<br />
diagnostic interventions should be carried out to provide a complete<br />
evaluation of the situation.<br />
Explanation:<br />
GoR B<br />
Conventional radiography and/or computed tomography are used for the diagnostic tests [13]. In<br />
order to visualize corresponding regions, a panoramic slice view (orthopantomogram), paranasal<br />
sinuses view, specific dental X-rays, and a Clementschitsch p.a. view of the skull or a lateral<br />
view of the skull are taken. Using computed tomography, progressive intracranial pressure signs,<br />
asymmetries, fractures, and larger maxillofacial defects as well as the degree of dislocation can<br />
be visualized [9, 11, 23, 24]. Axial, sagittal, and coronal slices can be calculated [9, 18] (EL 3,<br />
EL 4). Preoperative planning can be carried out in more detail using computed tomography [4,<br />
9]. This entails a reduction in operating time and higher quality [9, 21].<br />
Emergency room – Mandible and midface 253
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
For small deformities, preference can be given to radiographic visualization on 2 planes with<br />
lower radiation exposure [17]. Pages et al. point out that, especially in children who are more<br />
sensitive than adults to the effects of ionizing rays by a factor of 3, particular attention should be<br />
paid because of the danger to eyes [14].<br />
The methods of the imaging diagnostic test (radiography or CT) are usually determined by the<br />
type of concomitant injuries and the local availability of equipment.<br />
In the case of orbita involvement, some authors recommend visually evoked potentials (VEP) or<br />
electroretinograms (ERG) to evaluate the optic nerves [5, 6, 8]. Particularly in the cases where<br />
the clinical function diagnosis of the optic path is not possible or uncertain (as a result of<br />
unconsciousness, morphine doses, massive swelling), this can serve to objectify the optic path<br />
function and thus enable an early intervention.<br />
Emergency room – Mandible and midface 254
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Literature<br />
1. Alvi A, Doherty T, Lewen G (2003) Facial fractures<br />
and concomitant injuries in trauma patients.<br />
Laryngoscope 113:102-106<br />
2. Cannell H, Silvester Kc, O'regan Mb (1993) Early<br />
management of multiply injured patients with<br />
maxillofacial injuries transferred to hospital by<br />
helicopter. Br J Oral Maxillofac Surg 31:207-212<br />
3. Cantore Gp, Delfini R, Gambacorta D et al. (1979)<br />
Cranio-orbito-facial injuries: technical suggestions. J<br />
Trauma 19:370-375 [LoE 4]<br />
4. Carls Fr, Schuknecht B, Sailer Hf (1994) Value of<br />
three-dimensional computed tomography in<br />
craniomaxillofacial surgery. J Craniofac Surg 5:282-<br />
288 [LoE 3]<br />
5. Coutin-Churchman P, Padron De Freytez A (2003)<br />
Vector analysis of visual evoked potentials in<br />
migraineurs with visual aura. Clin Neurophysiol<br />
114:2132-2137 [LoE 4]<br />
6. Dempf R, Hausamen Je (2000) [Fractures of the facial<br />
skull]. Unfallchirurg 103:301-313 [LoE 5]<br />
7. Ellis E, 3rd, Scott K (2000) Assessment of patients<br />
with facial fractures. Emerg Med Clin North Am<br />
18:411-448, vi [LoE 4]<br />
8. Gellrich Nc, Gellrich Mm, Zerfowski M et al. (1997)<br />
[Clinical and experimental study of traumatic optic<br />
nerve damage]. Ophthalmologe 94:807-814 [LoE 5]<br />
9. Holmgren Ep, Dierks Ej, Homer Ld et al. (2004)<br />
Facial computed tomography use in trauma patients<br />
who require a head computed tomogram. J Oral<br />
Maxillofac Surg 62:913-918 [LoE 3]<br />
10. Larcan A, Bollaert Pe, Audibert G et al. (1990)<br />
[<strong>Polytrauma</strong>tized patient. First aid care, transport and<br />
resuscitation]. Chirurgie 116:615-621; discussion 622<br />
11. Lewandowski Rj, Rhodes Ca, Mccarroll K et al.<br />
(2004) Role of routine nonenhanced head computed<br />
tomography scan in excluding orbital, maxillary, or<br />
zygomatic fractures secondary to blunt head trauma.<br />
Emerg Radiol 10:173-175 [LoE 3]<br />
12. Mathiasen Ra, Eby Jb, Jarrahy R et al. (2001) A<br />
dedicated craniofacial trauma team improves<br />
efficiency and reduces cost. J Surg Res 97:138-143<br />
[LoE 2]<br />
13. Merville Lc, Diner Pa, Blomgren I (1989)<br />
Craniofacial trauma. World J Surg 13:419-439 [LoE<br />
5]<br />
14. Pages J, Buls N, Osteaux M (2003) CT doses in<br />
children: a multicentre study. Br J Radiol 76:803-811<br />
[LoE 2]<br />
15. Perry M (2008) Advanced Trauma Life Support<br />
(ATLS ® ) and facial trauma: can one size fit all? Part<br />
1: dilemmas in the management of the multiply<br />
injured patient with coexisting facial injuries. Int J<br />
Oral Maxillofac Surg 37:209-214 [LoE 3]<br />
16. Perry M, Morris C (2008) Advanced trauma life<br />
support (ATLS ® ) and facial trauma: can one size fit<br />
all? Part 2: ATLS ® , maxillofacial injuries and airway<br />
management dilemmas. Int J Oral Maxillofac Surg<br />
37:309-320<br />
17. Ploder O, Klug C, Backfrieder W et al. (2002) 2D-<br />
and 3D-based measurements of orbital floor fractures<br />
from CT scans. J Craniomaxillofac Surg 30:153-159<br />
[LoE 4]<br />
18. Pozzi Mucelli Rs, Stacul F, Smathers Rl et al. (1986)<br />
[3-dimensional craniofacial computerized<br />
tomography]. Radiol Med 72:399-404<br />
19. Regel G, Tscherne H (1997) [Fractures of the facial<br />
bones--second most frequent concomitant injury in<br />
polytrauma]. Unfallchirurg 100:329<br />
20. Sackett Dl, Richardson Ws, Rosenberg W et al.<br />
(1997) Evidence-based medicine: How to practice and<br />
teach EBM. Churchill Livingstone, London<br />
21. Santler G, Karcher H, Ruda C (1998) Indications and<br />
limitations of three-dimensional models in craniomaxillofacial<br />
surgery. J Craniomaxillofac Surg 26:11-<br />
16 [LoE 3]<br />
22. Schierle Hp, Hausamen Je (1997) [Modern principles<br />
in treatment of complex injuries of the facial bones].<br />
Unfallchirurg 100:330-337 [LoE 5]<br />
23. Thai Kn, Hummel Rp, 3rd, Kitzmiller Wj et al. (1997)<br />
The role of computed tomographic scanning in the<br />
management of facial trauma. J Trauma 43:214-217;<br />
discussion 217-218 [LoE 4]<br />
24. Treil J, Faure J, Braga J et al. (2002) [Threedimensional<br />
imaging and cephalometry of craniofacial<br />
asymmetry]. Orthod Fr 73:179-197 [LoE 4]<br />
Emergency room – Mandible and midface 255
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.14 Neck<br />
Key recommendations:<br />
Securing the airway must take priority when treating injuries to the neck. GoR A<br />
In the case of tracheal tears, avulsions or open tracheal injuries, surgical<br />
exploration with insertion of a tracheostoma or direct reconstruction should<br />
be carried out.<br />
In the case of all neck injuries, intubation or, if not possible, insertion of a<br />
tracheostoma should be given early consideration.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
Depending on the injury pattern, intubation must be given early consideration. This can be done<br />
transorally, transnasally, transvulnar or via tracheostomy. Even in the case of complete rupture<br />
of the trachea, distal sections can be intubated with defect bridging via endoscopic intubation. If<br />
oral or transnasal intubation is not possible, a tracheotomy must be considered [2].<br />
A tracheostomy is always an elective operation; in the acute emergency, access should be made<br />
via a coniotomy as an emergency tracheotomy [13]. In the case of tracheal tears, avulsions or<br />
open tracheal injuries, surgical exploration with insertion of a tracheostoma or direct<br />
reconstruction is recommended. In the case of injuries of short l<strong>eng</strong>th not involving all layers,<br />
conservative treatment can be attempted [6]. The same applies to trauma in the region of the<br />
larynx [2, 3, 14].<br />
Emergency room – Neck 256
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Diagnostic study<br />
Key recommendations:<br />
To confirm the type and severity of the injury, computed tomography of the<br />
neck soft tissues should be performed on hemodynamically stable patients.<br />
In the case of clinically or CT suspected neck injury, an endoscopic<br />
examination should be carried out on the traumatized region.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
In order not to generate any additional trauma through diagnostic or therapeutic measures, a<br />
search should first be made for injuries to the cervical spine or these should be minimized as<br />
much as possible through immobilization techniques [10, 12, 14]. Although the resulting injury<br />
sequelae from tracheal tears or avulsions can be visualized by means of imaging diagnostic tests<br />
(CT/MRI/conventional radiography), part of the actual lesion is often difficult to see. Skin<br />
emphysema after tracheal injury is given as an example, whereby the actual lesion can often not<br />
be identified in the imaging or cannot be visualized in conservative imaging if there is a<br />
pronounced hematoma on the neck without detectable source of bleeding. In addition,<br />
endoscopic examinations are recommended in the diagnostic evaluation of cervical injuries [1].<br />
If there are suspected vascular injuries, an alternative diagnostic procedure is duplex<br />
ultrasonography, which is a non-invasive examination procedure and equivalent to angiography<br />
[7, 8]; both thus represent the gold standard for injuries to the neck vessels. This applies<br />
especially to the neck zones I and III according to Roon and Christensen [12]. Surgical<br />
exploration is additionally recommended for zone II. Although this is hotly debated in the<br />
literature, it is not in dispute that 100% of defects can be identified and if necessary treated in<br />
this way [7, 12].<br />
Emergency room – Neck 257
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Treatment<br />
Key recommendations:<br />
Open neck trauma with acute bleeding should be compressed initially and<br />
then managed by surgical exploration thereafter.<br />
In the case of closed neck trauma, an assessment of the vascular status should<br />
be carried out.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
The angiography or alternatively duplex ultrasonography represent the gold standard for injuries<br />
to the neck vessels, especially in zones I and III according to Roon and Christensen [12].<br />
Surgical exploration is additionally recommended for zone II.<br />
The first-line choice for function and trauma diagnostic tests is Doppler ultrasonography, being<br />
the least invasive, rapid, and not cost-intensive examination method. This is at least equal in<br />
diagnostic evidence to angiography and computed tomography, and even superior due to its<br />
lesser invasiveness and lower costs and higher speed [7, 8, 12].<br />
Emergency room – Neck 258
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Demetriades D, Velmahos GG, Asensio JA. Cervical<br />
pharyngoesophageal and laryngotracheal injuries.<br />
World J Surg. 2001 Aug;25(8):1044-8 [LoE 2b]<br />
2. Dienemann H, Hoffmann H (2001). Tracheobronchial<br />
injuries and fistulas. Chirurg 72(10):1131-6 [LoE 3a]<br />
3 Donald, Paul J. Trachealchirurgie: Kopf – und Hals<br />
Chirurgie (H.H. Naumann et al) 1998 Georg Thieme<br />
Verlag (S. 243 - 57)<br />
4. Erhart J, Mousavi M, Vecsei V. Penetrating injuries of<br />
the neck, injury pattern and diagnostic algorithm.<br />
Chirurg. 2000 Sep;71(9):1138-43<br />
5. Etl S, Hafer G, Mundinger A. Cervical vascular<br />
penetrating trauma. Unfallchirurg. 2000<br />
Jan;103(1):64-7. German<br />
6. Gabor S, Renner H, Pinter H, Sankin O, Maier A,<br />
Tomaselli F, Smolle Juttner FM (2001). Indications<br />
for surgery in tracheobronchial ruptures. Eur J<br />
Cardiothorac Surg 20(2):399-404 [LoE 4]<br />
7. Ginzburg E, Montalvo B, LeBlang S, Nunez D,<br />
Martin L. The use of duplex ultrasonography in<br />
penetrating neck trauma. Arch Surg. 1996<br />
Jul;131(7):691-3 [LoE 1a]<br />
8. LeBlang SD, Nunez DB Jr. Noninvasive imaging of<br />
cervical vascular injuries. AJR Am J Roentgenol.<br />
2000 May;174(5):1269-78 [LoE 4]<br />
9. Munera F, Soto JA, Palacio D, Velez SM, Medina E.<br />
Diagnosis of arterial injuries caused by penetrating<br />
trauma to the neck: comparison of helical CT<br />
angiography and conventional angiography.<br />
Radiology. 2000 Aug;216(2):356-62<br />
10. Oestreicher E, Koch O, Brucher B. Impalement injury<br />
of the neck. HNO 2003 Oct;51(10):829-32 [LoE 4]<br />
11. Pitcock, J. Traumatologie der Halsweichteile:Kopf –<br />
und Hals Chirurgie (H.H. Naumann et al) 1998 Georg<br />
Thieme Verlag (S. 459 - 75)<br />
12. Roon AJ, Christensen N. Evaluation and treatment of<br />
penetrating cervical injuries. J Trauma. 1979<br />
Jun;19(6):391-7 [LoE 2a]<br />
13. Walz MK. Tracheostomy: indications, methods,<br />
risks.Chirurg. 2001 Oct;72(10):1101-10 [LoE 2a]<br />
14. Welkoborsky, H. – J. Verletzungen der Halsregion<br />
und der Halswirbelsäule: Praxis der HNO –<br />
Heilkunde, Kopf- und Halschirurgie (J. Strutz, W.<br />
Mann) 2001 Georg Thieme Verlag (S. 843-6) [LoE 4]<br />
Emergency room – Neck 259
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.15 Resuscitation<br />
Criteria for cardiac arrest<br />
Key recommendations:<br />
In the case of definitive cardiac arrest, uncertainties in detecting a pulse or<br />
other clinical signs that make cardiac arrest likely, resuscitation must be<br />
started immediately.<br />
Explanation:<br />
GoR A<br />
A cardiac cause accounts for around 70-90% of patients affected by cardiac arrest. A posttraumatic<br />
cause accounts for only 3.1% of cases [1] and these patients have a markedly worse<br />
prognosis. Based on retrospective analyses of patient collectives, mainly from the 1980s to<br />
1990s, an average survival rate of about 2% and, in the absence of serious neurologic deficits,<br />
only 0.8% is given in the “ERC Guidelines for Resuscitation 2005”, with slightly better survival<br />
for penetrating injuries than for blunt trauma [2]. Somewhat better prognoses have been<br />
published in more recent studies [3-5]. In an analysis of the <strong>DGU</strong> Trauma Registry of 10,359<br />
patients from the period 1993-2004, 17.2% of the multiply injured patients were successfully<br />
resuscitated after traumatic cardiac arrest, 9.7% of whom with a moderate to good neurologic<br />
outcome (Glasgow Outcome Scale [GOS] ≥ 4, Table 12). Seventy-seven (10%) of the<br />
resuscitated patients received an emergency thoracotomy with a survival rate of 13% [6]. In<br />
some studies, survival after traumatic and non-traumatic cardiac arrest was even comparable [7].<br />
Table 12: Glasgow Outcome Scale (GOS) [8]:<br />
Classification of course after traumatic brain injury with intracranial lesions and neuronal<br />
damage (point scale 1-5):<br />
1. Died as a result of acute brain damage<br />
2. Apallic, permanent vegetative condition<br />
3. Severely disabled (mentally and/or physically), requiring permanent care, no earning<br />
capacity<br />
4. Moderately disabled, mostly independent but marked neurologic and/or psychiatric<br />
disorders, considerable restriction in earning capacity<br />
5. Not/mildly disabled, normal life despite possible minor deficits, only slight or no<br />
restriction in earning capacity<br />
The criteria for detecting cardiac arrest in trauma patients do not differ from the criteria in nontraumatic<br />
cardiac arrest. The diagnosis to resuscitate the trauma patient must be made according<br />
to the guidelines of the European Resuscitation Council and, when indicated, must be started or<br />
continued [37]. The main criterion in the diagnosis of cardiac arrest in a traumatized patient in<br />
the emergency room is also apnea in combination with absence of pulse with/without electrical<br />
activity of the heart. In earlier resuscitation guidelines, the conscious state, breathing, and<br />
circulation were checked first [8, 9]. However, studies have meanwhile shown that both<br />
Emergency room - Resuscitation 260
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
checking for the absence of spontaneous breathing [10, 11] and particularly checking for absence<br />
of pulse [11, 12] is beset with a high error rate even by trained personnel. Low specificity in<br />
particular could lead to a delay in resuscitation.<br />
Medical personnel in the emergency room should search for a maximum of 10 seconds for the<br />
presence or absence of a central pulse. In case of doubt or if there are other clinical signs that<br />
make cardiac arrest likely, resuscitation should be started immediately [13].<br />
An allegedly normal ECG does not exclude cardiac arrest in terms of an electromechanical<br />
decoupling (pulseless electrical activity) any more than a pathologic or even possibly artificially<br />
altered ECG provides evidence of blood circulation [13]. Nevertheless, an immediate ECG<br />
recording is an essential component in monitoring in the emergency room and is always included<br />
in the evaluation of the cardiovascular situation.<br />
If there is suspicion or evidence of cardiac arrest, the ECG and its changes also determine the use<br />
and timing of defibrillation treatment [13]. Pulse oxymetry and particularly also capnography are<br />
essential components in monitoring a multiply injured patient. Both procedures are able to<br />
indicate cardiac arrest (absent pulse wave in pulse oxymetry, rapidly falling etCO2 in<br />
capnography). However, the limitations of pulse oxymetry in shock, centralization, and<br />
hypothermia should be noted.<br />
Emergency room - Resuscitation 261
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Are there special features to note when resuscitating trauma patients?<br />
Key recommendation:<br />
During resuscitation, trauma-specific reversible causes of cardiac arrest (e.g.,<br />
airway obstruction, esophageal intubation, hypovolemia, tension<br />
pneumothorax or pericardial tamponade) should be diagnosed and treated.<br />
An intraarterial catheter should be inserted for invasive continuous blood<br />
pressure measurement.<br />
Explanation:<br />
GoR A<br />
GoR B<br />
In principle, establishing the indication for resuscitation even in the trauma patient must be done<br />
according to the guidelines of the ERC [2, 13]. More recent analyses on trauma-associated<br />
cardiac arrest show much better survival [3-6]. This is chiefly due to more advanced emergency<br />
systems and more consistent application of resuscitation guidelines (see Figure 4) as well as to<br />
adherence to emergency room algorithms. The survival rates correlate above all with the<br />
prehospital rescue time and the period of cardiopulmonary resuscitation [2, 14–17].<br />
The main causes of cardiac arrest after a trauma are severe traumatic brain injury and massive<br />
bleeding [2, 18, 19]. The success of cardiopulmonary resuscitation is only ensured if the cause of<br />
cardiac arrest can be treated. To ascertain the trauma-specific reversible causes of cardiac arrest,<br />
the tube placement should be monitored by auscultation and capnometry/capnography,<br />
ultrasonography of the abdomen, pleural space, cardiac ventricles, and pericardium (standardized<br />
procedure if possible, e.g., FAST), and the hemoglobin value in the BGA measured during<br />
ongoing cardiopulmonary resuscitation.<br />
Current studies in the Federal Republic of Germany have detected a frequency of esophageal<br />
intubations in up to 7% of cases, and so immediate monitoring of the correct placement of the<br />
tracheal tube by auscultation and capnometry/capnography is indispensable immediately after<br />
intubation both by the emergency physician and after the patient has arrived in the emergency<br />
room [20].<br />
With emergency ultrasonography (e.g., FAST) [21, 22] and with recording the hemoglobin value<br />
in the (arterial or venous) blood gas analysis, etiologic abdominal or thoracic massive bleeding<br />
should be recorded during resuscitation and appropriate aggressive volume replacement and<br />
specific surgical treatment carried out. With pronounced hypovolemia, the use of hyperosmolar<br />
solutions and dispensing with PEEP ventilation can be expedient to improve preload and cardiac<br />
fill rapidly. If hypovolemia is the cause of cardiac arrest, the success rate of cardiopulmonary<br />
resuscitation can be increased with these measures [19, 23].<br />
Retrospective analyses showed that the insertion of chest drains could be valued as a positive<br />
predictor for survival after post-traumatic cardiac arrest, which could be explained by the<br />
removal or prevention of a tension pneumothorax [6, 24–26].<br />
Emergency room - Resuscitation 262
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
According to expert opinion of the guideline project group, the early insertion of an intraarterial<br />
catheter into the femoral artery for invasive continuous blood pressure measurement can<br />
objectify the diagnosis of cardiac arrest and the efficiency of resuscitation efforts in the<br />
emergency room. In so doing, there must be no interruption or delay in cardiopulmonary<br />
resuscitation due to the insertion of the intraarterial catheter.<br />
Emergency room - Resuscitation 263
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Figure 4: CPR algorithm according to the ERC Guidelines [36]<br />
Shock indicated<br />
Ventricular fibrillation/<br />
pulseless ventricular tachycardia<br />
1 shock<br />
Immediately resume:<br />
CPR for 2 min<br />
Minimize interruptions<br />
Advance Life Support for Adults (ALS):<br />
© by European Resuscitation Council (ERC) 2010<br />
During CPR<br />
• ensure highly qualified CPR: rate, depth, decompression<br />
• plan actions prior to CPR interruption<br />
• give oxygen<br />
• airway management; consider capnography<br />
• cardiac massage without interruption if airway secured<br />
• vascular access: intravenous, intraossary<br />
• inject adrenalin every 3-5 min<br />
• treat reversible causes<br />
Unresponsive?<br />
Respiratory arrest or only gasping breaths<br />
Cardiopulmonary resuscitation<br />
(CPR) 30 : 2<br />
Attach defibrillator/ECG monitor<br />
Minimize interruptions<br />
Assess<br />
ECG rhythm<br />
Circulation<br />
re-starts<br />
spontaneously<br />
Immediate treatment<br />
• use ABCDE algorithm<br />
• give oxygen + ventilation<br />
• 12-lead ECG<br />
• treat trigger factors<br />
• temperature control/<br />
therapeutic hypothermia<br />
Immediately resume:<br />
CPR for 2 min<br />
Minimize interruptions<br />
Emergency room - Resuscitation 264<br />
X<br />
Notify resuscitation team/<br />
emergency services<br />
Shock not indicated<br />
(PEA/asystole)<br />
Reversible causes<br />
• Hypoxia<br />
• Hypovolemia<br />
• Hypo-/hyperkalemia/metabolic<br />
• Hypothermia<br />
• Pericardial tamponade<br />
• Intoxication<br />
• Thrombosis (AMI, LAE)<br />
• Tension pneumothorax
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Failure and discontinuation criteria<br />
Key recommendation:<br />
If resuscitation is unsuccessful after eliminating possible trauma-specific<br />
causes of cardiac arrest, cardiopulmonary resuscitation must be stopped.<br />
If there are definite signs of death or injuries that are not compatible with life,<br />
cardiopulmonary resuscitation must not be started.<br />
Explanation:<br />
GoR A<br />
GoR A<br />
Most multiply injured patients die in the early phase from the consequences of severe traumatic<br />
brain injuries and massive bleeding [2, 18, 19]. Injuries not compatible with life may be present<br />
(e.g., injuries to the great vessels). The success of cardiopulmonary resuscitation firstly depends<br />
on the time since cardiac arrest occurred and secondly on the possibility of eliminating traumaspecific<br />
causes of cardiac arrest during resuscitation. Despite implementation of the aforementioned<br />
therapeutic measures (e.g., insertion of a chest drain) to eliminate trauma-specific<br />
causes of cardiac arrest, cardiopulmonary resuscitation can be unsuccessful. If no causes can be<br />
established during cardiopulmonary resuscitation or if the elimination of possible traumaspecific<br />
causes does not lead to a return of spontaneous circulation [ROSC]), resuscitation must<br />
be discontinued. The recognized definite signs of death signal an irreversible cell death of organs<br />
essential for life and are therefore indicators for failure of cardiopulmonary resuscitation. If there<br />
are definite signs of death or injuries that are not compatible with life, cardiopulmonary<br />
resuscitation must not be started. The decision to continue or discontinue cardiopulmonary<br />
resuscitation is the responsibility of the treating physicians and must be made in consensus. A<br />
time limit for unsuccessful resuscitation cannot be given.<br />
Emergency room - Resuscitation 265
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
What importance does the emergency thoracotomy have in post-traumatic cardiac arrest<br />
in the emergency room?<br />
Key recommendation:<br />
Emergency thoracotomy should be performed in the case of penetrating<br />
injuries, particularly if the onset of cardiac arrest is recent and vital signs are<br />
initially present.<br />
Explanation:<br />
GoR B<br />
Performing an emergency thoracotomy is described as being relatively straightforward [27, 28]<br />
but requires, according to the ATLS ® criteria of the American College of Surgeons [29], a<br />
trained, experienced surgeon and, according to the <strong>DGU</strong> guidelines [30], the availability of a<br />
thoracotomy set in the emergency room.<br />
Based on a meta-analysis of 42 studies with a total of 7,035 documented “emergency department<br />
thoracotomies”, the American College of Surgeons has published a guideline on the indication<br />
for and performance of an emergency room thoracotomy under cardiopulmonary resuscitation<br />
[31]. The resulting statements are based chiefly on the finding that, with an overall survival rate<br />
of 7.8%, only 1.6% of patients survived after blunt trauma but 11.2% after penetrating trauma.<br />
An emergency room resuscitative thoracotomy can improve the prognosis particularly in the case<br />
of penetrating trauma and appears to be particularly expedient if vital signs are initially present<br />
[31-33]. Appropriate logistic equipment is mandatory [34]. In blunt trauma, on the other hand, an<br />
emergency thoracotomy should be carried out more reluctantly. If an emergency thoracotomy is<br />
performed and there is simultaneously intraabdominal massive bleeding, a laparotomy to arrest<br />
the bleeding should be performed parallel to the thoracotomy. Appropriate logistic equipment is<br />
mandatory [35].<br />
Emergency room - Resuscitation 266
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Pell JP, Sirel JM, Marsden AK, et al. Presentation,<br />
management, and outcome of out of hospital<br />
cardiopulmonary arrest: comparison by underlying<br />
aetiology. Heart 2003;89:839-42<br />
2. Soar J, Deakin CD, Nolan JP, et al. European<br />
Resuscitation Council Guidelines for Resusitation<br />
2005. Section 7. Cardiac arrest in special<br />
circumstaandes. Resusitation 2005 ;67S1:S135-S170<br />
[Evidenzbasierte Leitlinie]<br />
3. Hess EP, Campell RL, et al. Epidemiology, trends,<br />
and outcome of out6-of hospital cardiac arrest of noncardiac<br />
origin. Resusitation 2007;72:200-206 [LoE<br />
2c]<br />
4. Pickens K, Copass JMK, et al. Trauma patients<br />
receiving CPR: predictors of survival. J Trauma<br />
2005;58:951-958 [LoE 2c]<br />
5. Willis CD, Cameron PA, Bernard SA, Fitzgerald M.<br />
Cardiopulmonary resuscitation after traumatic cardiac<br />
arrest is not always futile. Injury 2006;37:448-454<br />
[LoE 2c]<br />
6. Huber-Wagner S, Lefering R, Qvick M, et al.<br />
Outcome in 757 severely injured patients with<br />
traumatic cardiorespiratory arrest. Resuscitation<br />
2007;75:276-285 [LoE 2c]<br />
7. David, JS, Gueugniaud PY, Riou B, et al. Does the<br />
prognosis of cardiac arrest differ in trauma patients?<br />
Crit Care Med 2007;35:2251-2255<br />
8. Handley AJ, Becker LB, Allen M, et al. Single rescuer<br />
adult basic life support. An advisory statement from<br />
the Basic Life Support Working Group of the<br />
International Liaison Committee on Resuscitation<br />
(ILCOR). Resuscitation 1997;34:101-108 [LoE 1c]<br />
9. Basic Life Support Working Group of the European<br />
Resuscitation Council European Resuscitation<br />
Council guidelines for adult single rescuer basic life<br />
support. Resuscitation 1998;37:67-80<br />
[Evidenzbasierte Leitlinie]<br />
10. Ruppert M, Reith MW, Widmann JH, et al. Checking<br />
for breathing: Evaluation of the diagnostic capability<br />
of emergency medical services personnel, physicians,<br />
medical students, and medical laypersons. Ann Emerg<br />
Med 1999;34:720-729 [LoE 1b]<br />
11. Cummins RO, Hazinsk MF. Cardiopulmonary<br />
resuscitation techniques and instruction: When does<br />
evidence justify revision? Ann Emerg Med<br />
1999;34:780-784 [LoE 1b]<br />
12. Eberle B, Dick WF, Schneider T, et al. Checking the<br />
carotid pulse check: diagnostic accuracy of first<br />
responers in patients with and without a pulse.<br />
Resuscitation 1996;33:107-116 [LoE 1b]<br />
13. International Liaison Committee on Resuscitation.<br />
2005 International consensus on cardiopulmonary<br />
resuscitation and emergency cardiovascular care<br />
science with treatment recommendations.<br />
Resuscitation 2005;67:181–341 [LoE 1c]<br />
14. Fulton RL, Voigt WJ, Hilakos AS. Confusion<br />
surrounding the treatment of traumatic cardiac arrest.<br />
J Am Coll Surg 1995;181:209-214 [LoE 2c]<br />
15. Gervin AS, Fischer RP. The importance of prompt<br />
transport of salvage of patients with penetrating heart<br />
wounds. J Trauma 1982;22:443-448 [LoE 2c]<br />
16. Durham III LA, Richardson RJ, Wall Jr MJ, Pepe PE,<br />
Mattox KL. Emergency center thoracotomy: impact of<br />
prehospital resuscitation. J Trauma 1992;32:775-779<br />
[LoE 2c]<br />
17. Powell DW, Moore EE, Cothren CC, et al. Is<br />
emergency department resuscitative thoracotomy<br />
futile care for the critically injured patient requiring<br />
prehospital cardiopulmonary resuscitation? J Am Coll<br />
Surg 2004;199:211-215 [LoE 2c]<br />
18. Søreide K, Krüger AJ, Vårdal AL, et al. Epidemiology<br />
and Contemporary Patterns of Trauma Deaths:<br />
Changing Place, Similar Pace, Older Face. World J<br />
Surg. 2007;31:2092-2103<br />
19. Bansal V, Fortlage D, Lee JG, et al. Hemorrhage is<br />
More Prevalent than Brain Injury in Early Trauma<br />
Deaths: The Golden Six Hours. Eur J Trauma Emerg<br />
Surg 2009;35:26–30<br />
20. Timmermann A, Russo SG, Eich C, et al. The out-ofhospital<br />
esophageal and endobronchial intubations<br />
performed by emergency physicians. Anesth Analg<br />
2007;104:619-623<br />
21. Geeraedts LM Jr, Kaasjager HA, van Vugt AB, Frölke<br />
JP. Exsanguination in trauma: A review of diagnostics<br />
and treatment options. Injury 2009 40:11-20 [LoE 1b]<br />
22. Ollerton JE, Sugrue M, Balogh Z, et al. Prospective<br />
study to evaluate the influence of FAST on trauma<br />
patient management. J Trauma 2006;60:785-791 [LoE<br />
1b]<br />
23. Herff H, Paal P, von Goedecke A, et. al. Ventilation<br />
strategies in the obstructed airway in a bench model<br />
simulating a nonintubated respiratory arrest patient.<br />
Anesth Analg 2009 ;108:1585-1588<br />
24. Deakin CD, Davies G, Wilson A. Simple<br />
thoracostomy avoids chest drain insertion in<br />
prehospital trauma. J Trauma 1995;39:373-374 [LoE<br />
2a]<br />
25. Mistry N, Bleetman A, Roberts KJ. Chest<br />
decompression during the resuscitation of patients in<br />
prehospital traumatic cardiac arrest. Emerg Med J<br />
2009;26:738-740 [LoE 2a]<br />
26. Bushby N, Fitzgerald M, Cameron P et al. Prehospital<br />
intubation and chest decompression is associated with<br />
unexpected survival in major thoracic blunt trauma.<br />
Emerg Med Australas 2005;17:443-449 [LoE 2a]<br />
27. Wise D, Davies G, Coats T, et al. Emergency<br />
thoracotomy: ‘‘how to do it’’. Emerg Med J<br />
2005;22:22-24<br />
28. Voiglio EJ, Coats TJ, Baudoin YP, Davies GD,<br />
Wilson AW. Resuscitative transverse thoracotomy.<br />
Ann Chir 2003;128:728-733<br />
29. American College of Surgeons – Committee on<br />
Trauma (2008) ATLS ® : Advanced Trauma Life<br />
Support for Doctors, 8th ed. American College of<br />
Surgeons, Chicago [LoE 5]<br />
30. Arbeitsgruppe Unfallchirurgische Leitlinien der<br />
Deutschen Gesellschaft für Unfallchirurgie (<strong>DGU</strong>) in<br />
Emergency room - Resuscitation 267
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Zusammenarbeit mit der Arbeitsgemeinschaft<br />
<strong>Polytrauma</strong> der Deutschen Gesellschaft für<br />
Unfallchirurgie e.V. (2002) <strong>Polytrauma</strong>:<br />
http://www.uniduesseldorf.de/WWW/AWMF/awmffrs.htm<br />
[LoE 5]<br />
31. Working Group, Ad Hoc Subcommittee on Outcomes,<br />
American College of Surgeons-Committee on<br />
Trauma. Practice management guidelines for<br />
emergency department thoracotomy. J Am Coll Surg<br />
2001;193:303-309 [Evidenzbasierte Leitlinie]<br />
32. Karmy-Jones R, Nathens A, Jurkovich GJ, et al.<br />
Urgent and emergent thoracotomy for penetrating<br />
chest trauma. J Trauma 2004;56:664-668; discussion<br />
668-9 [LoE 2c]<br />
33. Powell DW, Moore EE, Cothren CC, et al. Is<br />
emergency department resuscitative thoracotomy<br />
futile care for the critically injured patient requiring<br />
prehospital cardiopulmonary resuscitation? J Am Coll<br />
Surg 2004;199:211-215 [LoE 2c]<br />
34. Seamon MJ, Fisher CA, Gaughan JP, et al.<br />
Emergency department thoracotomy: survival of the<br />
least expected. World J Surg 2008;32: 604-612<br />
35. Fialka C, Sebok C, Kernetzhofer P, et al. Open-chest<br />
cardiopulmonary resuscitation after cardiac arrest in<br />
cases of blunt chest or abdominal trauma: a<br />
consecutive series of 38 cases. J Trauma 2004;57:809-<br />
814<br />
36. Deakin CD, Nolan JP et al. Erweiterte Reanimationsmaßnahmen<br />
für Erwachsene („advanced life<br />
support“). Notfall&Rettungsmedizin 2010; 13(7):<br />
p. 559-620<br />
37. Nolan JP, Deakin CD, Soar J et al. (2005) European<br />
Resuscitation Council Guidelines for Resuscitation<br />
2005. Section 4. Adult advanced life support.<br />
Resuscitation 67(1): <strong>S3</strong>9-S86<br />
Emergency room - Resuscitation 268
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.16 Coagulation system<br />
The term “polytrauma” refers to a very heterogeneous patient group. Perioperative coagulation<br />
therapy, particularly in this patient population, was carried out for decades according to gut<br />
instinct. The attempt to find a broader basis for medical management led to expert<br />
recommendations, which were based on physiologic concepts as well as pharmacologic and<br />
pharmacodynamic considerations. Increasingly, there are experimental and clinical studies on<br />
individual research questions. Even if the pathophysiologic correlations between the therapy<br />
choices described and the impaired coagulation can be presented conclusively and coherently,<br />
confirmation through randomized controlled trials is still awaited for virtually all<br />
recommendations. As with the 4th edition of the “Cross-Sectional Guideline on Therapy using<br />
Blood Components and Plasma Derivatives” by the German Medical Association (BÄK), the<br />
following recommendations are largely based on case observations and not randomized studies.<br />
Thus, the majority of conclusions can only be awarded a grade of recommendation [GoR] 0. For<br />
this reason, and also because of the partly considerable costs of the replacements described, it<br />
must be emphasized that the listed threshold values should in no way be seen as a cue for simply<br />
improving laboratory measurements. Rather, the indication for replacement using the cited drugs<br />
is only given in the event of massive, life-threatening bleeding [70].<br />
Trauma-induced coagulopathy<br />
Key recommendations:<br />
Trauma-induced coagulopathy is an autonomous clinical picture with clear<br />
influences on survival. For this reason, coagulation diagnostic tests and<br />
therapy must be started immediately in the emergency room.<br />
Thrombelastography and thrombelastometry can be carried out to guide the<br />
coagulation diagnostic test and coagulation replacement.<br />
Explanation:<br />
GoR A<br />
GoR 0<br />
The early trauma-induced mortality is usually a consequence of traumatic brain injury (40-50%<br />
of deaths) or of massive bleeding (20-40%). Bleeding is greatly increased by additional<br />
coagulopathy [102]. A coagulation disorder in multiply injured patients (trauma-induced<br />
coagulopathy [TIC]) has been known for over 20 years [61]. This coagulopathy was originally<br />
seen as a secondary occurrence, i.e. caused by loss/dilution and intensified by acidosis and<br />
hypothermia (“lethal triad”, “bloody vicious circle”) [55]. However, evidence of the existence of<br />
an autonomous, multifactorial, primary disease, which is intensified by the secondary factors<br />
(consumption, loss, dilutional coagulopathy), has been found in the present literature [9, 95],<br />
even in the Federal Republic of Germany [76]. TIC significantly influences the survival of<br />
multiply injured patients [72, 74]. It is independently correlated with a 4 to 8 times increased allcause<br />
case fatality rate [72] and 8 times increased case fatality rate within 24 hours [76]. Patients<br />
who are coagulopathic on admission to the emergency room remain longer in the intensive care<br />
Emergency room – Coagulation system 269
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
unit and in hospital, have a higher risk of renal insufficiency and multi-organ failure, have to be<br />
ventilated for longer, and exhibit a trend towards increased lung failure [8, 76]. An<br />
internationally valid, uniform term for this clinical picture is still lacking; suggestions are “acute<br />
traumatic coagulopathy” [10], “coagulopathy of trauma” [47], and “acute coagulopathy of<br />
trauma shock” [46]. The hypoperfusion and hyperfibrinolysis induced by the tissue injury and<br />
the shock are the triggers of TIC [9, 46]. The extent of hyperfibrinolysis appears to be correlated<br />
to the injury severity [67]. In a retrospective analysis, Schöchl et al. [102] found evidence of<br />
hyperfibrinolysis with an ISS > 25 in almost 15% of cases. TIC is already present on arrival in<br />
the emergency room in about 30% of the multiply injured and leads to an increased case fatality<br />
rate [10, 72, 74, 76, 95]. As there is no intravasal coagulation and thrombosis in the early phase<br />
of a trauma, this clinical picture does not involve disseminated intravasal coagulopathy (DIC)<br />
[34, 47].<br />
The definition of massive bleeding consists of a blood loss of ≥ 100% of blood volume within 24<br />
hours, of ≥ 50% within 3 hours, and 150 ml/min or 1.5 ml/kg BW/min over 20 minutes [114].<br />
Diagnostic test: While the clinical picture of TIC is characterized by non-surgical, diffuse<br />
bleeding from mucous membrane, serous membrane, and wound areas, occurrence of bleeding<br />
from puncture sites of intravasal catheters and bleeding from indwelling bladder catheters or<br />
abdominal tubes, there is a gross lack of suitable laboratory parameters [70]. The prothrombin<br />
time/Quick test/INR and the partial thromboplastin time are poor determinants of a reduced level<br />
of coagulation factors and weak predictors for bleeding tendency in critically ill patients [15, 66].<br />
In addition, these parameters only measure the time to the start of clot formation. A conclusion<br />
on the clotting str<strong>eng</strong>th and quality, its fibrinolytic activity or platelet function is not possible [7].<br />
A prompt diagnostic test on the patient is also not possible.<br />
The “classic” laboratory parameters are measured at 37 °C, buffered, with excess of calcium in<br />
serum and plasma. Thus, acidosis, hypothermia, hypocalcemia, and anemia are not included [36,<br />
71] although these factors can have a considerable effect [71]. However, due to the<br />
epidemiologically increasing number of elderly patients, anticoagulation must be assumed in the<br />
case of trauma in this clientele. An INR > 1.5 in the over-50s is thus correlated with a<br />
significantly increased case fatality rate; this applies particularly to traumatic brain injuries<br />
[134]. Data from trauma registries showed that a prolonged prothrombin time in traumatized<br />
patients is a predictor for mortality [10, 72, 94]. Hess et al. [48] were able to confirm that<br />
pathologic “classic” laboratory parameters occurred with increasing frequency with increasing<br />
injury severity. These pathologic values, particularly the Quick test/INR, were associated with an<br />
increased case fatality rate.<br />
Thrombelastography: (Rotational) thrombelastography (TEG) and (rotational)<br />
thrombelastometry (RoTEM) are being increasingly studied for the monitoring of multiply<br />
injured patients. In contrast to the standard coagulation test, this allows not only the time until<br />
onset of coagulation but also the speed of clot formation and the maximum clotting firmness to<br />
be recorded. This test procedure can be carried out without delay in the emergency room. Thus,<br />
treatment decisions can be made sooner [92, 95]. Several TEG/RoTEM-based algorithms for<br />
trauma management have already been published (e.g., [36, 59, 64]).<br />
Emergency room – Coagulation system 270
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
In the pig model for massive bleeding, Martini et al. [80] found a better correlation of<br />
thrombelastographic parameters compared to the Quick test, to PTT (partial thromboplastin<br />
time) or to INR. In a prospective observation study, Rugeri et al. [95] showed in 88 patients that<br />
different RoTEM parameters with a sensitivity and specificity between 74 and 100% are suitable<br />
for visualizing in vivo the changes in coagulation. The results from Levrat et al. [67] on 87<br />
trauma patients lay in the same range for sensitivity and specificity. The trauma-induced<br />
hyperfibrinolysis in particular could be effectively confirmed. In 44 soldiers with penetrating<br />
injuries, Plotkin et al. [92] noted the TEG as a more precise indicator than the Quick test, PTT or<br />
INR for the need for blood products. Schöchl et al. [101] measured mortality-predicting<br />
hyperfibrinolysis using ROTEM in 33 critically injured patients: The time of fibrinolysis within<br />
30 minutes after the start of coagulation, after 30-60 minutes, and after more than 60 minutes<br />
correlated with the mortality rate (100%, 91%, 73%), late fibrinolysis allowing the best<br />
prognosis (p = 0.0031). The results were available within 10-20 minutes and showed an<br />
increasing number of hyperfibrinolyses with increasing injury severity.<br />
The use of thrombelastography and thrombelastometry in traumatized patients is very promising<br />
for guiding the coagulation diagnostic tests and replacement, particularly in the case of<br />
hyperfibrinolyses [11], but requires further prospective evaluation [70, 111].<br />
Emergency room – Coagulation system 271
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Damage control resuscitation<br />
Key recommendations:<br />
In patients who are actively bleeding, the goal can be set at permissive<br />
hypotension (mean arterial pressure ~ 65 mmHg, systolic arterial pressure<br />
~ 90 mmHg) until surgical hemostasis. This strategy is contraindicated in<br />
injuries of the central nervous system.<br />
Suitable measures should be taken and treatment given to avoid the patient<br />
cooling down.<br />
GoR 0<br />
GoR B<br />
Acidemia should be avoided and treated by suitable shock treatment. GoR B<br />
Hypocalcemia < 0.9 mmol/l should be avoided and can be treated. GoR 0<br />
Explanation:<br />
Similar to damage control surgery, where definitive anatomic management is temporarily<br />
deferred in favor of stabilizing the vital physiologic signs, the concept of damage control<br />
resuscitation was developed to prevent trauma-induced coagulopathy [2]. Permissive<br />
hypotension, the prevention of acidemia, hypocalcemia and hypothermia, and the administration<br />
of coagulation-promoting products are part of this procedure [111]. The prerequisite for<br />
determining these parameters is consistent, invasive hemodynamic monitoring and the possibility<br />
for prompt, repetitive blood gas analyses.<br />
Permissive hypotension: The term describes 2 approaches: firstly, to tolerate a lower than normal<br />
blood pressure and even to aim towards that in order to support thrombus formation and,<br />
secondly, to infuse only a small amount of fluid in order to prevent iatrogenic dilution while still<br />
ensuring adequate perfusion of the end organs. The correlation between “normal” blood pressure<br />
and bleeding tendency in trauma was already known by the end of the First World War [12]. The<br />
idea evolved in the military environment of tolerating low blood pressure values with a radial<br />
pulse that could still be felt as long as no surgical hemostasis is warranted [2].<br />
The basis for the clinical application is a study by Bickell et al. [3] from 1994 of penetrating<br />
injuries in which patients with prehospital replacement therapy had an increased case fatality<br />
rate. The accompanying editorial [57] and a large number of readers’ letters mentioned the<br />
deficiencies in study design, conduct, and interpretation. Using the data from the German trauma<br />
registry, Maegele et al. [76] were able to show that an increasing frequency in coagulopathy<br />
occurred with increasing prehospital fluid therapy. In a randomized controlled trial with<br />
paramedics, Turner et al. [127] found no evidence in trauma patients of either advantage or<br />
disadvantage in prehospital fluid therapy (odds ratio [OR] for death from volume administration:<br />
1.07 with 95% CI: 0.73-1.54; with exclusion of ambiguous patient data: OR 1.04; 95% CI: 0.70–<br />
1.53). Dutton et al. [28] noted no change in the duration of active bleeding in each of 55<br />
Emergency room – Coagulation system 272
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
traumatized patients (51% penetrating injury), whose volume replacement was titrated to a<br />
systolic blood pressure of > 100 mmHg or 70 mmHg. However, the authors showed that a<br />
sudden reduction in fluid requirement with increasing blood pressure is a sign of arrested<br />
bleeding [26]. A Cochrane Review from 2003 [65] also found no evidence for or against early,<br />
greater volume therapy for uncontrolled bleeding.<br />
Due to pathophysiologic considerations, a target blood pressure of 65 mmHg as mean pressure or<br />
90 mmHg as systolic value is recommended in current review papers for patients with massive<br />
bleeding despite a lack of evidence-based proofs. As adequate perfusion pressure is necessary if<br />
there is damage to the central nervous system, this recommendation does not apply to patients<br />
with a traumatic brain injury [53, 74, 106, 123].<br />
Warming up: Hypothermia ≤ 34 °C has a major effect on platelet function and the activity of<br />
coagulation factors [71]. For the cooling down of the patient to be kept to a minimum, the initial<br />
fluid therapy must be provided exclusively by warmed infusions [2, 124] and, from the<br />
emergency room onwards, any volume therapy must be administered only via infusion warming<br />
devices with an infusion temperature of 40–42 °C [97, 124]. Both passive (e.g., foil space<br />
blankets, blankets, removal of wet clothing) and active measures (e.g., replacing<br />
infusions brought in with warmed infusions, constant use of heating pads, radiant heaters, hot air<br />
fans) are helpful. Both during the diagnostic study and later in the operating room, the room<br />
temperature should be as high as possible - in the thermoneutral zone if possible, i.e. 28–29 °C<br />
[97, 106, 126].<br />
In the pig model, hypothermia reduces thrombin formation in the initial phase and impairs<br />
fibrinogen formation [79]. The hypothermia-induced platelet dysfunction can be partially<br />
corrected in vitro with an infusion of desmopressin (DDAVP) in the typical dose of 0.3 µg/kg<br />
[135]. In a thrombelastography study, Rundgren et al. [96] found evidence of an increasing effect<br />
of coagulation with decreasing temperature in a temperature range of 25 to 40 °C. There are no<br />
randomized controlled trials on trauma patients.<br />
Acidosis balance: Acidosis ≤ 7.2 has a marked negative effect on coagulation [11, 71]. As the<br />
main cause of acidemia is hypoperfusion, acidosis will persist until adequate tissue perfusion is<br />
restored. Interventions that can intensify acidosis such as hypoventilation or NaCl infusion, for<br />
example, should be avoided [2]. The base excess (BE) also impairs coagulation [71] and can be<br />
used as prognostic evidence of complications and death [106]. Using data from M<strong>eng</strong> et al. [84],<br />
Zander et al. [137] showed that with a BE of - 15 the activity of various coagulation factors is<br />
halved. Critical values for the BE start in a range from - 6 to - 10 [106, 136].<br />
In the pig model, Martini et al. [81] could not achieve any improvement in coagulopathy through<br />
buffering. As a single measure, buffering to pH values of ≥ 7.2 thus apparently leads to no<br />
improvement in coagulopathy [7] and is only meaningful from a hemostaseologic viewpoint in<br />
combination with the administration of coagulation products. Even a massive transfusion of<br />
stored PRBC can strongly increase acidosis [107]. The BE of fresh PRBC is - 20 mmol/l but<br />
after 6 weeks - 50 mmol/l [71]. Acidosis reduces thrombin formation in the propagation phase<br />
and accelerates fibrinogenolysis [79]. In the pig model, Martini et al. [82] proved that sodium<br />
bicarbonate balances pH and BE but cannot normalize either the fibrinogen level or the impaired<br />
Emergency room – Coagulation system 273
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
thrombin formation. Tris(hydroxymethyl)aminomethane (TRIS, THAM) also did not impair the<br />
reduction in fibrinogen but stabilized the kinetics of thrombin generation in pigs. At present, it<br />
cannot be concluded which of the two substances is better suited for buffering for<br />
hemostaseologic reasons.<br />
Calcium replacement: The reduction in ionized calcium (Ca ++ ) after transfusions depends on the<br />
citrate used as anticoagulant in the banked blood and is particularly marked in fresh frozen<br />
plasma (FFP). The reduction is more marked the quicker the banked blood is transfused,<br />
particularly at a transfusion speed > 50 ml/min [11]. The calcium monoproducts available in<br />
Germany for intravenous use contain very variable amounts of calcium ions [69]. This must be<br />
taken into account during replacement. A marked impairment of coagulation must be assumed<br />
below an ionized Ca ++ concentration of 0.9 mmol/l [11].<br />
Emergency room – Coagulation system 274
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Replacement of coagulation-promoting products<br />
Key recommendations:<br />
A specific massive transfusion protocol should be introduced and continued. GoR B<br />
In an actively bleeding patient, the indication for transfusion can be made at<br />
hemoglobin levels below 10 g/dl or 6.2 mmol/l, and the hematocrit value<br />
maintained at 30%.<br />
If coagulation therapy in massive transfusions is carried out by administering<br />
FFP, the FFP:PRBC target ratio should be in the range of 1:2 and 1:1.<br />
Replacement of fibrinogen should be carried out if levels are at < 1.5 g/l<br />
(150 mg/dl).<br />
Explanation:<br />
GoR 0<br />
GoR B<br />
GoR B<br />
Packed red blood cells (PRBC): An increasing number of publications in the fields of trauma and<br />
intensive care point out the negative effect of PRBC administration on survival (see, for<br />
example, review in [2] or [125]). Malone et al. [77] noted in 15,534 trauma patients that a blood<br />
transfusion was a strong, independent predictor for mortality (OR 2.83; 95% CI: 1.82–4.40;<br />
p < 0.001). PRBC supplies aged > 14 days result in a significant worsening in survival both for<br />
mildly injured [131] as well as severely injured [130] trauma patients [110].<br />
However, the involvement of red blood corpuscles in coagulation is confirmed (see, for example,<br />
review in [43] or [71]). In a TIC, a restrictive transfusion trigger can be unfavorable [83] as<br />
significant impairments to coagulation develop clearly before oxygenation has an effect [43].<br />
While there are no randomized controlled data on hemostaseologically optimum hemoglobin and<br />
hematocrit values in polytrauma, target hemoglobin concentrations until arrest of bleeding<br />
should be in the range of 10 g/dl (6.2 mmol/l, hematocrit 30%) according to the German Medical<br />
Association, due to the favorable effects of higher hematocrit values on primary hemostasis in<br />
the case of massive, non-arrested hemorrhage [11]. The German Medical Association bases this<br />
recommendation on the review paper by Hardy et al. [42], which states that in bleeding patients<br />
experimental data indicate that hematocrit values of up to 35% are necessary to maintain<br />
hemostasis.<br />
Frozen fresh plasma (FFP): In a systematic review of randomized controlled trials, Stanworth et<br />
al. [116] found no evidence of efficacy of FFP transfusion either in the group of massive<br />
transfusions or in a wide variety of other indications but frequently found problems in study<br />
design. Chowdhury et al. [15] studied the efficacy of FFP administration in a cohort study of 22<br />
intensive patients. The often recommended volume of 10-15 ml/kg/BW did not lead to an<br />
adequate increase in factor concentration. This was only achieved with 30 ml/kg/BW, for which<br />
Emergency room – Coagulation system 275
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
the patients required a median volume of 2.5 l FFP. A randomized double-blind trial of 90<br />
patients with severe, closed traumatic brain injury (GCS ≤ 8) was carried out by Etemadrezaie et<br />
al. [29]. One group received a slow transfusion 10–15 ml/kg BW FFP while the control group<br />
received the same amount of common salt. In the FFP group, a new intracerebral hematoma<br />
developed more frequently (p = 0.012), and the patients had a significantly elevated mortality<br />
rate (63% versus 35%, p = 0.006). Hedim et al. [44] achieved a plasma dilution of 21% for 2.9<br />
hours with an infusion of only 10 ml/kg BW FFP.<br />
The transfusion of FFP also contains a series of risks: Dara et al. [20] noted a more frequent<br />
occurrence of acute lung injuries (ALI; 18% versus 4%, p = 0.021) after FFP transfusion in<br />
patients in the medical intensive care unit. Sperry et al. [109] found prospectively in 415 patients<br />
approximately double the TRALI (transfusion-associated acute lung insufficiency) risk with a<br />
ratio of FFP:PRBC > 1:1.5 (47.1% versus 24.0%, p = 0.001). Sarani et al. [99] showed after FFP<br />
transfusion in non-traumatized patients in the surgical intensive care unit a relative risk for the<br />
occurrence of an infection of 2.99, severe, ventilator-associated pneumonia of 5.42, severe<br />
bacteriemia of 3.35, and sepsis of 3.2 (each p < 001). There was a cumulative risk of infection of<br />
~ 4% per FFP. Chaiwat et al. [14] identified the transfusion of FFP in trauma as an independent<br />
predictor for ARDS in 14,070 trauma patients: relative risk after transfusion of 1-5 FFP of 1.66<br />
(95% CI: 0.88–3.15) and at > 5 FFP of 2.55 (95% CI: 1.17–5.55).<br />
The German Medical Association regards the prevention and treatment of microvascular<br />
bleeding as an indication for FFP but described the treatment of coagulopathy with FFP alone as<br />
of little efficacy (increased rate, volume loading) [11]. It recommends rapid transfusion of<br />
initially 20 ml/kg BW but emphasizes that higher volumes may be necessary. There are no<br />
controlled studies to determine effective plasma doses [11].<br />
FFP ratio to PRBC: The military field provided the first evidence that the replacement of lost<br />
blood volume by “full blood” can provide a survival advantage in critically injured patients with<br />
massive transfusions (> 10 PRBC/24 h) [93]. However, full blood is not available in the Federal<br />
Republic of Germany.<br />
Hirshberg et al. [51] showed the necessity of early FFP replacement on a computer model and<br />
they recommended an FFP:PRBC of 1:1.5 or the transfusion of 2 FFP with the first PRBC. Ho et<br />
al. [52] calculated on a mathematical model that a bleeding-induced heavy loss of coagulation<br />
factors can only be remedied with a transfusion of 1-1.5 FFP per PRBC; if the FFP<br />
administration starts before the factor concentration has dropped below 50%, then a 1:1 ratio is<br />
sufficient. Borgmann et al. [6] showed the advantage of a 1:1 replacement of FFP and PRBC in<br />
military personnel. A retrospective study was carried out on the survival of 246 soldiers who had<br />
received replacement in a ratio of 1:8, 1:2.5 or 1:1.4. The hemorrhage-induced case fatality rates<br />
were 92.5%, 78%, and 37% (p < 0001). In the regression analysis, the FFP:PRBC ratio was<br />
linked independently with survival and discharge from hospital (OR 8.6; 95% CI: 2.1–35.2).<br />
Dente et al. [21] prospectively compared 73 civil patients after introducing a massive transfusion<br />
protocol containing PRBC, FPP, and platelets in the ratio 1:1:1 with 84 patients before<br />
introducing the protocol. The results showed a drastic reduction in early coagulopathy (p<br />
= 0.023), 24-hour case fatality rate (17% versus 36%, p = 0.008), and 30-day case fatality rate<br />
for blunt trauma (34% versus 55%, p = 0.04). In 135 patients, Duchesne et al. [24] proved a<br />
Emergency room – Coagulation system 276
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
significant survival advantage with an FFP-PRBC ratio of 1:1 compared to 1:4 (26% versus<br />
87.5%, p = 0.0001). Gonzalez et al. [39] compared the results of their massive transfusion<br />
protocol on 97 patients for the emergency room (PRBC:FFP > 2:1) with those of the ICU<br />
protocol (PRBC:FFP = 1:1). A TIC present on arrival in the emergency room could not be<br />
remedied until in the ICU, and the TIC at ICU admission correlated with the mortality rate (p<br />
= 0.02). A significantly reduced 30-day mortality was noted by Gunter et al. [41] for patients<br />
who received FFP and PRBC in a ratio ≥ 2:3 (41% versus 62%, p = 0.008). In a multicenter<br />
study of 466 patients, Holcomb et al. [54] showed that an FFP-PRBC ratio ≥ 1:2 compared to<br />
< 1:2 permitted better 30-day survival (40.4% versus 59.9%, p < 001). The combination of a<br />
high FFP-PRBC and a high platelet-PRBC ratio increased the 6-hour, 24-hour, and 30-day<br />
survival (p < 005). Kashuk et al. [60] showed the advantage of a 1:2 FFP-PRBC ratio (survivors:<br />
median 1:2, non-survivors: median 1:4, p < 0001) in 133 civil patients who received a massive<br />
transfusion within 6 hours. The authors nevertheless found a U-shaped curve: patients who<br />
received FFP and PRBC in the ratio 1:2 to 1:3 had the highest survival rate whereas the predicted<br />
mortality probability increased again with a ratio of 1:1. The authors thus recommended a ratio<br />
of 1:2 to 1:3. In 713 patients in the German trauma registry who required ≥ 10 PRBC until ICU<br />
admission, Maegele et al. [75] detected a survival advantage in relation to the PRBC-FFP ratio of<br />
> 1:1, 1:1 or < 1:1 (6 hours: 24.6% versus 9.6% versus 3.5%, p < 00001; 24 hours: 32.6% versus<br />
16.7% versus 11.3%, p < 00001; 30 days: 45.5% versus 35.1% versus 24.3%, p < 0001). The<br />
ratio < 1:1 led to a longer ventilation dependency and a longer stay in ICU (p < 00005). In 415<br />
patients with an FFP-PRBC ratio of > 1:1.5, Sperry et al. [109] found prospectively a significant<br />
24-hour survival advantage (3.9% versus 12.8%, p = 0.012) with increased TRALI risk (47.1%<br />
versus 24.0%, p = 0.001). Scalea et al. [100] prospectively studied 250 patients. No survival<br />
advantage with a PRBC-FFP ratio of 1:1 was registered either in the total population or in the 81<br />
massively transfused patients. With a total mortality within 24 hours of only 4% (6% with<br />
massive transfusions), the authors concluded that other (less severely injured) patients had been<br />
studied than in the majority of other studies. In 383 trauma patients (exclusion: severe TBI),<br />
Teixeira et al. [121] showed a linear increase in survival with increasing FFP-PRBC ratio up to a<br />
ratio of 1:3. After the admission GCS, the FFP-PRBC ratio was the second most important<br />
predictor for survival. Snyder et al. [105] retrospectively carried out an outcome study on 134<br />
patients who required transfusion ≥ 10 PRBC/24 h. They noted a significantly reduced 24-hour<br />
mortality of 40% when FFP and PRBC were administered in a ratio ≥ 1:2 (median 1:1.3)<br />
compared to 58% at < 1:2 (median 1:3.7) (relative risk [RR] 0.37, 95% CI: 0.22–0.64). However,<br />
the significance could no longer be confirmed if the exact time of FFP transfusion within the first<br />
24 hours was taken into account (RR 0.84, 95% CI: 0.47–1.50). The authors justified this with a<br />
potential “survival bias”: the patients did not die because they received less FFP but received less<br />
FFP because they died. In a randomized multicenter study, by means of a high FFP-PRBC ratio,<br />
Zink et al. [138] significantly improved survival in massive transfusions within 6 hours (37.3%<br />
at < 1:4 versus 15.2% at 1:4 to 1:1 versus 2.0% at ≥ 1:1; p < 0001) and lowered the total number<br />
of required PRBC (18 PRBC in the first 24 hours at < 1:1 versus 13 PRBC at > 1:1, p < 0001).<br />
The majority of studies available indicate that patients who (will) require massive transfusions or<br />
have a life-threatening shock gain from a high FFP-PRBC ratio [111].<br />
Emergency room – Coagulation system 277
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Massive transfusion protocol: The term “massive transfusion” mostly implies the transfusion of<br />
≥ 10 PRBC per 24 hours [111]; but as the highest mortality of multiply injured patients occurs<br />
within the first 6 hours, some authors also recommend ≥ 10 PRBC per 6 hours [60]. In Cotton et<br />
al. [19], the introduction of a massive transfusion protocol with an FFP-PRBC ratio of 1:1.5 led<br />
to a 74% fall in mortality probability (p = 0.001) and to a higher 30-day survival rate (56.8%<br />
versus 37.6%, p < 0001) [18] with shorter stay (12 days versus 16 days, p = 0.049) and fewer<br />
ventilation days (5.7 days versus 8.2 days, p = 0.017). The authors attributed the improved<br />
survival to the earlier and faster infusion of the increased FFP-PRBC ratio. After introducing a<br />
massive transfusion protocol, Dente et al. [21] found evidence of an improved 24-hour survival<br />
(previously 36% versus 14%, p = 0.008) and 30-day survival (previously 55% versus 34%, p<br />
= 0.04) and a lower early mortality due to the coagulopathy (previously 21/31 versus 4/13, p<br />
= 0.023).<br />
The Trauma Associated Severe Hemorrhage (TASH) Score of the German <strong>DGU</strong> Trauma<br />
Registry [136] can be used in the civil arena for predicting a massive transfusion. It comprises<br />
the factors systolic blood pressure, hemoglobin (Hb), BE, heart rate, free intraabdominal fluid,<br />
pelvic and femoral fracture, and male sex (0-28 points). An increasing TASH score could be<br />
attributed with good accuracy and discrimination to an increasing probability for a massive<br />
transfusion (area under the curve [AUC] 0.89). Nunez et al. [88] developed a prediction system<br />
for massive transfusions [assessment of blood consumption (ABC)] with the parameters<br />
penetrating injury, positive finding from focused trauma sonography (FAST), systolic blood<br />
pressure on arrival ≤ 90 mmHg and heart rate ≥ 120/min. For a value ≥ 2, they could attribute a<br />
sensitivity of 75% and a specificity of 86% to this score.<br />
Platelet concentrates (PC): In the case of acute loss, platelets are initially increasingly released<br />
from bone marrow and spleen, which is why there is quite a delay before the platelet count falls<br />
after bleeding starts. After transfusion, the transferred vital platelets are distributed in the blood<br />
and the spleen so that the recovery rate in the peripheral blood is only about 60-70% and even<br />
lower with DIC [11].<br />
In their retrospective multicenter study of civil trauma patients, Holcomb et al. [54] showed an<br />
improved 30-day survival with a PC-PRBC ratio of ≥ 1:2 (40.1% versus 59.9%, p < 001). The<br />
PC:PRBC ratio was an independent predictor for mortality. Perkins et al. [90] studied the effect<br />
on 694 soldiers who received massive transfusions of apharesis platelet concentrate (aPC) in<br />
relation to PRBC in 3 groups (aPC:PRBC 1:16, 1:18 to < 1:8 and > 1:8). The transfusion of aPC<br />
and PRBC in a ratio > 1:8 was characterized by a significantly higher 24-hour (64% versus 87%<br />
versus 95%, p < 0001) and 30-day survival (43% versus 60% versus 75%, p < 0001). In the<br />
multivariate analysis, the aPC-PRBC ratio was independently linked with the 24-hour and 30day<br />
survival. In a PRBC-FFP platelet ratio of 1:1:1, Dente et al. [21] noted a drastic reduction in<br />
early coagulopathy (p = 0.023), 24-hour case fatality rate (17% versus 36%, p = 0.008) and 30day<br />
case fatality rate in blunt trauma (34% versus 55%, p = 0.04). The randomized multicenter<br />
study by Zink et al. [138] with massive transfusion within 6 hours yielded significantly better<br />
values for the high ratio (6-hour survival: 22.8% versus 19% versus 3.2%, p < 0002; hospital<br />
survival: 43.7% versus 46.8% versus 27.4%, p < 003) for the 3 groups with a PC-PRBC ratio of<br />
< 1:4, 1:4 to 1:1 and ≥ 1:1.<br />
Emergency room – Coagulation system 278
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
If the patient is in acute danger due to a massive blood loss or due to the location (intracerebral<br />
bleeding), the German Medical Association recommends platelet replacement if the value falls<br />
below 100,000/µl [11]. If there are resulting platelet dysfunctions and tendency to bleed, a<br />
concomitant therapy with antifibrinolytics or desmopressin can be indicated [11].<br />
Fibrinogen: As the substrate of coagulation, factor I (= fibrinogen) is essential not only for the<br />
formation of the fibrin network but is also a ligand for the GPIIb-IIIa receptor at the platelet<br />
surface and thus responsible for platelet aggregation. During dilution or severe bleeding,<br />
fibrinogen appears to be the most vulnerable of all coagulation factors and is the first to reach its<br />
critical concentration [11, 50]. As early as 1995, Hiippala [50] had confirmed in patients who<br />
received a colloid transfusion that the measurement of derived fibrinogen (measured using the<br />
Quick test) as well as fibrinogen measured using the method according to Clauss produces<br />
significantly higher values than correspond to the actual fibrinogen levels. According to the<br />
German Medical Association, the administration of 3 g fibrinogen in a volume of 3 liters of<br />
plasma elevates the measured fibrinogen concentration by approximately 1 g/l; initial doses of<br />
(2–) 4 (–6) g are thus necessary in adults [11].<br />
Singbartl et al. [104] illustrated in a mathematical model that the maximum permissible blood<br />
loss until the critical fibrinogen value has been reached is dependent on the baseline value.<br />
However, this is generally not known in the initial management during emergency admission.<br />
Fries et al. [35] showed in an in vitro study that dilution occurs through infusion of crystalloid or<br />
colloid solutions, inter alia also through 6% HES 130/0.4. Giving fibrinogen in a concentration<br />
which when converted was roughly equivalent to 3 g/70 kg BW was sufficient to achieve an<br />
improvement in the RoTEM parameters. The cause of this effect is regarded as an effect of the<br />
interaction between thrombin, factor XIII, and fibrinogen; this particularly applies for a dilution<br />
through HES [86]. Madjdpour et al. [73] proved in the pig that, with varying molecular weight<br />
(900, 500, 130) and the same degree of replacement (0.42), HES impairs coagulation in a similar<br />
way. In thrombocytopenia induced in the pig model, Velik-Salchner et al. [128] normalized the<br />
impaired coagulation parameters in the TEG by administering fibrinogen. Mittermayr et al. [85]<br />
proved in 61 randomized patients with major spinal interventions that colloids reduce the speed<br />
and quality of clot formation through impaired fibrin polymerization. Stinger et al. [119] showed<br />
a highly significant correlation between the amount of fibrinogen administered and survival in<br />
252 patients who had been injured during the fighting in the Iraq war. Injured patients who<br />
received less than 1 g of fibrinogen per 5 PRBC showed a case fatality rate of 52% compared to<br />
24% if more than 1 g/5 PRBC was given. In establishing a concentration of < 2 g/l as indication<br />
for fibrinogen replacement (average 2 g, range 1-5 g), F<strong>eng</strong>er-Eriksen et al. [31] found evidence<br />
in 35 severely bleeding patients of a significant reduction in the required PRBC (p < 00001), FFP<br />
(p < 00001) and PC (p < 0001) and blood loss (p < 005). In 30 massively bleeding patients with<br />
hypofibrinogenemia of varying genesis, Weinkove et al. [132] raised the level of 0.65 to 2.01 g/l<br />
by giving 4 g of fibrinogen (median, range 2-14 g) (measurement according to Clauss). Farriols<br />
Danes et al. [30] showed that patients with acute, bleeding-induced hypofibrinogenemia<br />
(compared to chronic deficiency) reacted to fibrinogen replacement with a more marked increase<br />
and a significantly better 7-day survival rate (p = 0.014).<br />
Emergency room – Coagulation system 279
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The widely used optical coagulation monitoring devices measure false elevated fibrinogen values<br />
when plasma is displaced by colloids [49]. Determining the derived fibrinogen is not sufficient<br />
for deciding whether there is an indication for replacement in massive bleeding [11]. The<br />
German Medical Association recommends that in massive bleeding the fibrinogen concentration<br />
is measured using the Clauss method and that target values are set at ≥1.5 g/l (150 mg/dl) and<br />
with prior colloid exposure ≥2 g/l (200 mg/dl) [11]. If hyperfibrinolysis is suspected, an<br />
antifibrinolytic drug should be given beforehand (e.g., 2 g tranexamic acid) [11].<br />
Prothrombin concentrates (PPSB): The mixtures of vitamin K-dependent factors prothrombin =<br />
FII, proconvertin = FVII, Stuart factor = FX, and antihemophilic factor B = FIX, and protein C,<br />
protein S, and protein Z contain neither fibrinogen nor FV or FVIII [98] and are only<br />
standardized with regard to the factor IX content [11]. Activated coagulation factors and<br />
activated protein C or plasmin are virtually no longer contained in the PPSB products available<br />
now so that undesirable effects such as thromboembolic events, disseminated intravasal<br />
coagulation and/or hyperfibrinolytic bleeding are very unlikely even when larger quantities are<br />
administered [11]. The thromboembolisms described in the past were thought to be caused by a<br />
marked surplus in prothrombin in some PPSB concentrates no longer commercially available<br />
[40]. For this reason, it is no longer essential to replace antithrombin [11]. PPSB administration<br />
for DIC is only indicated if manifest bleeding exists which is partly caused by a lack of<br />
prothrombin complex factors and the cause of DIC is treated [11].<br />
The rationale for the use of PPSB compared to FFP is the absence of risk of transfusion-induced<br />
(lung) injuries and viral safety. The main indication for PPSB is the elimination of the effect of<br />
vitamin K antagonists. This indication is proven by many studies and, in the case of<br />
marcumarized patients, the German Medical Association [11] recommends the preoperative<br />
administration of PPSB as a prophylaxis for bleeding. In the case of trauma-induced,<br />
consumption, loss or dilutional coagulopathy, the deficiency in the prothrombin complex can be<br />
so pronounced that, despite transfusion of FFP, replacement with PPSB is also necessary [11,<br />
98]. Fries et al. [33] carried out dilutional coagulopathy with 6% HES 130/0.4 in the pig model.<br />
Fibrinogen and PPSB replacement after a standardized liver laceration led to a significantly<br />
lower blood loss (240 ml, range 50-830 versus 1,800 ml, range 1,500-2,500, p < 00001) and the<br />
survival of all animals whereas 80% of the control group died (p < 00001). Also in the pig,<br />
Dickneite et al. [22] showed a significant shortening in the time to hemostasis (median 35 versus<br />
82.5 min; p < 00001) and a trend towards reduced blood loss (mean value 275 versus 589 ml)<br />
through the sole administration of PPSB after arterial bleeding (spleen incision) with dilutional<br />
coagulopathy. After venous bleeding (bone fracture), there were significant reductions both in<br />
the time to hemostasis (median 27 versus 97 min; p < 00011) and in the blood loss (mean value<br />
71 versus 589 ml, p < 00017). The same working group [23] studied the efficacy of PPSB<br />
compared to FFP administration (15 and 40 ml/kg BW) in pigs with HES-induced dilutional<br />
coagulopathy. In this instance as well, PPSB reduced the time to hemostasis (venous bone<br />
trauma p = 0.001; arterial spleen trauma p = 0.028) and blood loss (venous bone trauma p<br />
= 0.001; arterial spleen trauma p = 0.015).<br />
In the case of severe bleeding, the German Medical Association recommends initial bolus doses<br />
of 20-25 IU/kg BW; marked individual fluctuations in efficacy must be taken into account [11].<br />
Emergency room – Coagulation system 280
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Antifibrinolytic drugs: Hyperfibrinolysis now appears to be more frequently assumed than before<br />
in multiply injured patients (~ 15% in [102]) and the extent correlates with the injury severity<br />
[67]. Hyperfibrinolysis is most common in patients with chest trauma, blunt abdominal trauma,<br />
pelvic trauma, and traumatic brain injury [58]. A prompt diagnosis of hyperfibrinolysis and also<br />
of the effectiveness of antifibrinolytic treatment is only possible by means of<br />
thrombelastography [67, 101]. The administration of the antifibrinolytic drug must be part of an<br />
overall therapeutic plan for the treatment of coagulopathies because hyperfibrinolysis can often<br />
involve heavy consumption of fibrinogen or even complete defibrination of the patient [58]. This<br />
fibrinogen deficiency must then be appropriately balanced after the manifestation of<br />
hyperfibrinolysis [58], i.e. the antifibrinolytic drug should be administered before the fibrinogen<br />
if hyperfibrinolysis is suspected [11]. Tranexamic acid is a synthetic lysine analogue, which<br />
inhibits the conversion of plasminogen into plasmin by blocking the plasminogen from binding<br />
to the fibrin molecule. The onset of effect of tranexamic acid is delayed compared to aprotinin as<br />
free plasmin continues to be active [102]. With a lack of evidence for multiply injured patients, it<br />
is recommended that initially 2–4 g (10–30 mg/kg BW [36, 58] is administered or a bolus dose<br />
of 10–15 mg/kg BW followed by 1–5 mg/kg BW/h [106].<br />
Due to a lack of evidence-based data, a Cochrane Review from 2004 [17] could neither confirm<br />
nor refute the administration of antifibrinolytics in trauma patients. Another Cochrane Review<br />
from 2007 on the question of reducing perioperative blood transfusions through antifibrinolytic<br />
drugs [45] established for tranexamic acid a relative risk for PRBC administration of 0.61 (95%<br />
CI: 0.54-0.70) and a trend towards fewer re-operations. Tranexamic acid reduced the necessity of<br />
a blood transfusion relatively by 43% (RR 0.57; 95% CI: 0.49–0.66). A cumulative occurrence<br />
of serious side effects was not noted. A study published in The Lancet in 2010 (CRASH<br />
[Clinical Randomization of Antifibrinolytics in Significant Hemorrhage]-2 Study) [16] supports<br />
this conclusion: 1 g of tranexamic acid in 10 minutes + 1 g over 8 hours led to a significant<br />
reduction in all-cause mortality and in bleeding-induced mortality without an increased rate in<br />
thromboembolisms.<br />
Desmopressin (DDAVP): Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic<br />
vasopressin analogue. Desmopressin (e.g., Minirin®) effectuates nonspecific platelet activation<br />
(increased expression of the platelet GpIb receptor [89]), releases the von Willebrand factor and<br />
FVIII from the endothelium of the hepatic sinusoids, and thus improves primary hemostasis [32].<br />
The main indication lies in perioperative treatment of von Willebrand syndrome. DDAVP also<br />
shows good efficacy in patients after heparin administration and with restricted platelet function<br />
due to taking aspirin (acetyl salicylic acid) or ADP receptor antagonists/thienopyridine<br />
derivatives with uremia and with liver disease or thrombocytopenia [32]. The maximum effect<br />
after i.v. administration occurs only after about 90 minutes [68]. With repeated administration,<br />
the tissue plasminogen activator (tPA) can be released, thereby possibly leading to<br />
hyperfibrinolysis. Thus, with repeated administration, some authors recommend simultaneous<br />
administration of tranexamic acid [68]. In cardio-surgical patients, a not significantly increased<br />
rate in heart attacks was confirmed after DDAVP (OR 2.07; 95% CI: 0.74–5.85; p = 0.19) [68].<br />
Ying et al. [135] corrected in vitro the hypothermia-induced dysfunctions in hemostasis at least<br />
partially through DDAVP. Whereas the Cochrane Review of 18 studies with 1,295 patients by<br />
Carless et al. [13] could not confirm any efficacy for the prophylactic administration of<br />
Emergency room – Coagulation system 281
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
desmopressin, Zotz et al. [139] searched the same available data for the subgroup of patients who<br />
had either > 1 l blood loss or a history of taking aspirin. For the therapeutic use of DDAVP, there<br />
was thus a significantly reduced blood loss (weighted mean difference [WMD] = - 386 ml; 95%<br />
CI: - 542- - 231 ml per patient; p = 0.0001) and a likewise significantly reduced, transfused<br />
blood volume (WMD = - 340 ml, 95% CI = - 547- - 134 ml per patient; p = 0.0001). There are<br />
currently no controlled studies of trauma patients.<br />
From a pathophysiologic viewpoint, a treatment attempt with DDAVP can be considered in a<br />
dose of 0.3 µg/kg BW over 30 minutes in diffusely bleeding patients with suspected<br />
thrombocytopathy.<br />
Factor XIII: In the presence of calcium ions, FXIII effectuates the covalent crosslinking of the<br />
fibrin. A three-dimensional fibrin network is thus formed which effectuates definitive wound<br />
healing [11]. Factor XIII is not recorded by the Quick and aPTT (activated partial thromboplastin<br />
time) coagulation screening tests as these tests only measure the time fibrin formation starts but<br />
not fibrin crosslinking [11].<br />
An acquired deficiency is not rare and can arise with a TIC as a result of increased rate<br />
(increased blood loss, hyperfibrinolysis, DIC) and consumption (in major surgery). In patients<br />
with existing coagulation activation, e.g., through having a tumor, a severe FXIII deficiency and<br />
subsequent massive bleeding can result from a trauma or intraoperatively [62]. A lower FXIII<br />
level has been shown as a risk factor for bleeding in intracranial [37] and cardio-surgical [4, 38]<br />
interventions as well. In elective patients with unexpected intraoperative bleeding, Wettstein et<br />
al. [133] established a significantly higher blood loss (1,350 ml versus 450 ml; p < 0001) and a<br />
markedly more rapid consumption of fibrinogen and FXIII (p < 0001) compared with a nonbleeding<br />
collective. Korte et al. [63] found evidence in a prospective, randomized, double-blind<br />
pilot study of 22 patients who were to receive surgery for colon cancer and had activated<br />
coagulation (elevated preoperative fibrin monomers) of a significantly smaller reduction in clot<br />
firmness) and a trend towards less blood loss with a single dose of 30 IU/kg FXIII. There are no<br />
randomized studies on trauma patients.<br />
If testing for FXIII cannot be done promptly, blind administration of FXIII should be considered,<br />
especially in severe, acute bleeding [11]. Initially, 15-20 IU/kg BW is recommended as a<br />
possible dose until hemostasis. As the concentrate is produced from human plasma, a residual<br />
risk of infection cannot be excluded.<br />
Recombinant activated factor VII (rFVIIa): The approval of rFVIIa is restricted to bleeding in<br />
antibody hemophilia (antibodies to factors VIII or IX), Glanzmann thrombasthenia (inherited<br />
dysfunction of the platelet GPIIb-IIIa receptor), and inherited FVII deficiency. In a<br />
supraphysiologic dose, rFVIIa binds to the activated platelets and there effectuates a “thrombin<br />
burst”, which leads to the formation of an extremely stable fibrin clot [34]. On activated<br />
platelets, rFVIIa can also enable tissue factor-independent thrombin generation.<br />
Off-label use has been described in a large number of case histories. Adverse side effects in the<br />
form of thromboembolic events in the arterial and venous vascular system and in perioperatively<br />
or traumatically damaged vessels have been reported particularly in off-label use [11]. Perkins et<br />
Emergency room – Coagulation system 282
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
al. [91] showed in soldiers from the Iraq war that early administration of rFVIIa could lower<br />
PRBC consumption by 20%. Of 365 massive transfused patients, 117 received rFVIIa. Likewise,<br />
in patients in the military who received massive transfusions, Spinella et al. [113] noted a<br />
reduced 24-hour (14% versus 35%, p = 0.01) and 30-day mortality rate (31% versus 51%,<br />
p = 0.03) in early (median 2 hours after admission and 2.5 hours after trauma) administration of<br />
rFVIIa. However, the logistic options for preparation of, for example, blood components under<br />
war conditions cannot be compared with those of a European hospital. In the study in 2005 by<br />
Boffard et al. [5], the efficacy of 400 µg/kg BW rFVIIa (after the 8th PRBC initially 200<br />
µg/kg BW, then 100 µg/kg BW each after 1 and 3 hours) as adjunctive therapy was tested<br />
compared to placebo in 143 blunt and 134 penetrating trauma injuries. In blunt trauma, there was<br />
a significant reduction in the number of transfused PRBCs (calculated reduction by 2.6 PRBC, p<br />
= 0.02) and in the necessity for a transfusion of ≥ 20 PRBC (14% versus 33%; p = 0.03). In<br />
penetrating injuries, there was a trend in this direction for both parameters. Neither a lowering in<br />
the mortality rate nor an accumulation of thromboembolic side effects was observed. In 2009,<br />
Stein et al. [117] posed the question of costs. With the same rate of mortality and side effects, the<br />
authors could establish no significant difference in the costs (mean value US$63,403<br />
conventionally versus US$66,086 in rFVIIa) in 179 patients with traumatic brain injury. For the<br />
110 patients who were placed in the intensive care unit, there was even a significant cost<br />
reduction through rFVIIa (mean value US$108,900 conventionally versus US$77,907 in rFVIIa).<br />
However, really low doses were used in this study (5.9–115 µg/kg BW; mean value<br />
41.9 ± 35.5 µg/kg BW, median 25.1 µg/kg BW). Several meta-analyses of RCTs have studied<br />
the efficacy of off-label use: Stanworth et al. [115] found 13 placebo-controlled, double-blind<br />
RCTs on the use of rFVIIa in patients who were not hemophiliac. In prophylactic use (n = 724,<br />
379 received rFVIIa), there was a trend towards reduced transfusion frequency (pooled RR 0.85;<br />
95% CI: 0.72-1.01), which contradicts a trend towards increased thromboembolisms (pooled RR<br />
1.25; 95% CI: 0.76–2.07). In therapeutic use (n = 1,214; 687 received rFVIIa), there was a trend<br />
towards reduced mortality (pooled RR 0.82; 95% CI: 0.64-1.04) and again a trend towards<br />
increased thromboembolisms (RR 1.50; 95% CI: 0.86–2.62). In 2008, Hsia et al. [56] published<br />
the results of 22 RCTs on bleeding of different genesis in 3,184 non-hemophiliac patients (only<br />
the study by Boffard et al. [5] contains 301 trauma patients). The result was a reduced need for<br />
transfusion (OR 0.54; 95% CI: 0.34–0.86), a trend towards reduced case fatality rate (OR 0.88;<br />
95% CI: 0.71–1.09) and no change in venous but a trend towards cumulative arterial<br />
thromboembolisms (OR 1.50; 95% CI: 0.93–2.41). In 2008, Duchesne et al. [25] examined 19<br />
studies of trauma patients: Based on Boffard et al. [5], the authors gave a Level 1<br />
recommendation for the use of rFVIIa in blunt trauma. A Level 2 recommendation was given for<br />
trauma-associated hemorrhaging with 400 µg/kg BW (lower dose could also be effective) if<br />
other treatment options failed. Early use was assessed as Level 3. In 2009, Nishijima et al. [87]<br />
only found the above-mentioned study by Boffard [5] on the question of rFVIIa use in the<br />
emergency room. A large international phase III study on the use of rFVIIa in trauma patients<br />
was recently discontinued as the planned lowering in mortality could not be achieved [111].<br />
The effectiveness of rFVIIa and of the coagulation sequences thus indicated is linked to a series<br />
of “framework conditions”, which should be attained before administration: fibrinogen value<br />
≥ 1 g/dl, Hb ≥ 7 g/dl, platelet count ≥ 50,000 (preferably ≥ 100,000)/µl), ionized calcium<br />
≥ 0.9 mmol/l, core temperature ≥ 34 °C, pH value ≥ 7.2, and the exclusion of hyperfibrinolysis<br />
Emergency room – Coagulation system 283
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
or a heparin effect [11, 34, 106, 120]. A widely-used “standard dose” for off-label use is<br />
90 µg/kg BW [27, 56, 129]. However, the necessary dose remains ambiguous [106]; a very high<br />
total dose of 400 µg/kg BW is used in the only class 1 study by Boffard et al. [5]. Due to the very<br />
short half-life, a repeat dose can be considered after 2 hours [108] even if the need for a repeat<br />
dose is more likely to indicate a lack of effectiveness according to the review by Dutton et al.<br />
[27].<br />
The German Medical Association refers in its guidelines to the review article by Mannucci et al.<br />
[78]. Its conclusion states that rFVIIa is no wonder substance but possesses efficacy in patients<br />
with trauma and excessive bleeding who do not respond to other treatment options. Its use, but<br />
only after conventional treatments have not been successful, is also propagated in current<br />
reviews [25, 27, 56]. The current summary of product characteristics from NovoNordisc (May<br />
2009) recommends that rFVIIa is not used off-label due to the risk of arterial thrombotic events<br />
in the range of ≥ 1/100 to < 1/10.<br />
Antithrombin: There are no prospective randomized studies on multiply injured patients.<br />
However, with persistent massive bleeding, administration of antithrombin (formerly ATIII) will<br />
only intensify it and cannot therefore be recommended [74, 106]. In their meta-analysis of<br />
randomized controlled trials of critically ill intensive care patients (AT: n = 1,447, control: n<br />
= 1,482), Afshari et al. [1] recorded a significant increase in the risk of bleeding through the<br />
administration of antithrombin (RR 1.52, 95% CI: 1.30–1.78, I2 = 0.3%). Even if this could not<br />
confirm any lowering in the case fatality rate, the German Medical Association recommends an<br />
off-label use of ATIII only in confirmed DIC with confirmed ATIII deficiency [11].<br />
Emergency room – Coagulation system 284
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Summary table<br />
The above-described drug treatment options can be summarized as follows (modified according<br />
to [70, 118]):<br />
Table 13: Drug options for coagulation therapy<br />
1. Stabilization of framework<br />
conditions (prophylaxis and therapy)<br />
Core temperature ≥ 34 °C<br />
pH value ≥ 7.2<br />
ionized Ca ++ concentration ≥ 0.9 mmol/l<br />
2. Replacement of oxygen carriers PRBC administration (functional goal: Hb 6 [–8] g/dl<br />
but hemostaseologic goal in massive bleeding:<br />
Hct ≥ 30% and Hb ~10 g/dl [6.2 mmol/l])<br />
3. Inhibiting potential<br />
(hyper)fibrinolysis<br />
(always BEFORE administering<br />
fibrinogen!)<br />
4. Replacement of coagulation factors<br />
(in the case of sustained tendency for<br />
severe bleeding)<br />
and (if suspected thrombocytopathy)<br />
nonspecific platelet activation +<br />
release of the “von Willebrand factor”<br />
and FVIII from the endothelium<br />
5. Replacement of platelets for<br />
primary hemostasis<br />
6. If necessary, thrombin burst with<br />
platelet and coagulation activation<br />
(please note requirements!!)<br />
if active bleeding no antithrombin<br />
Tranexamic acid initially 2 g (15–30 mg/kg BW) or<br />
1 g as saturation over 10 minutes + 1 g over 8 h<br />
FFP ≥ 20 (more likely 30) ml/kg BW<br />
If coagulation therapy in massive transfusions is<br />
carried out by administering FFP, the FFP:PRBC ratio<br />
should be in the target range of 1:2 and 1:1.<br />
and fibrinogen (2–) 4 (–8) g (30–60 mg/kg BW;<br />
goal: ≥ 150 mg/dl and ≥ 1.5 g/l)<br />
and if necessary PPSB initially 1,000–2,500 IU<br />
(25 IU/kg BW)<br />
if necessary 1–2x FXIII 1,250 IU (15–20 IU/kg BW)<br />
if necessary DDAVP = desmopressin 0.3 µg/kg BW<br />
over 30 minutes (“1 ampoule per 10 kg BW”)<br />
platelet concentrates (goal for transfusion-dependent<br />
bleeding: 100,000/µl)<br />
in the individual case & if all other treatment options<br />
are unsuccessful<br />
if necessary initially 90 µg/kg BW rFVIIa<br />
Emergency room – Coagulation system 285
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Afshari A, Wetterslev J, Brok J et al. (2007)<br />
Antithrombin III in critically ill patients: systematic<br />
review with meta-analysis and trial sequential<br />
analysis. BMJ 335: 1248-1251 [LoE 1a]<br />
2. Beekley AC (2008) Damage control resuscitation: a<br />
sensible approach to the exsanguinating surgical<br />
patient. Crit Care Med 36: S267-S274<br />
3. Bickell WH, Wall MJ, Jr., Pepe PE et al. (1994)<br />
Immediate versus delayed fluid resuscitation for<br />
hypotensive patients with penetrating torso injuries. N<br />
Engl J Med 331: 1105-1109<br />
4. Blome M, Isgro F, Kiessling AH et al. (2005)<br />
Relationship between factor XIII activity, fibrinogen,<br />
haemostasis screening tests and postoperative<br />
bleeding in cardiopulmonary bypass surgery. Thromb<br />
Haemost 93: 1101-1107<br />
5. Boffard KD, Riou B, Warren B et al. (2005)<br />
Recombinant factor VIIa as adjunctive therapy for<br />
bleeding control in severely injured trauma patients:<br />
two parallel randomized, placebo-controlled, doubleblind<br />
clinical trials. J Trauma 59: 8-15 [LoE 1b]<br />
6. Borgman MA, Spinella PC, Perkins JG et al. (2007) The<br />
ratio of blood products transfused affects mortality in<br />
patients receiving massive transfusions at a combat<br />
support hospital. J Trauma 63: 805-813 [LoE 2c]<br />
7. Brohi K, Cohen MJ, Davenport RA (2007) Acute<br />
coagulopathy of trauma: mechanism, identification<br />
and effect. Curr Opin Crit Care 13: 680-685<br />
8. Brohi K, Cohen MJ, Ganter MT et al. (2007) Acute<br />
traumatic coagulopathy: initiated by hypoperfusion:<br />
modulated through the protein C pathway? Ann Surg<br />
245: 812-818<br />
9. Brohi K, Cohen MJ, Ganter MT et al. (2008) Acute<br />
coagulopathy of trauma: hypoperfusion induces<br />
systemic anticoagulation and hyperfibrinolysis. J<br />
Trauma 64: 1211-1217 [LoE 2b]<br />
10. Brohi K, Singh J, Heron M et al. (2003) Acute<br />
traumatic coagulopathy. J Trauma 54: 1127-1130<br />
[LoE 3b]<br />
11. Bundesärztekammer (BÄK). Querschnitts-Leitlinien<br />
(BÄK) zur Therapie mit Blutkomponenten und<br />
Plasmaderivaten 2009 - 4.Auflage. Erreichbar unter:<br />
http://www.bundesaerztekammer.de/downloads/LeitQ<br />
uerBlutkomponenten4Aufl.pdf<br />
12. Cannon W, Frawer J, Cowell E (1918) The preventive<br />
treatment of wound shock. JAMA 70: 618-621<br />
13. Carless PA, Henry DA, Moxey AJ et al. (2004)<br />
Desmopressin for minimising perioperative allogeneic<br />
blood transfusion. Cochrane Database Syst Rev<br />
CD001884<br />
14. Chaiwat O, Lang JD, Vavilala MS et al. (2009) Early<br />
packed red blood cell transfusion and acute<br />
respiratory distress syndrome after trauma.<br />
Anesthesiology 110: 351-360 [LoE 2b]<br />
15. Chowdhury P, Saayman AG, Paulus U et al. (2004)<br />
Efficacy of standard dose and 30 ml/kg fresh frozen<br />
plasma in correcting laboratory parameters of<br />
haemostasis in critically ill patients. Br J Haematol<br />
125: 69-73 [LoE 4]<br />
16. CRASH-2 trial collaborators, Shakur H, Roberts I,<br />
Bautista R, et al. Effects of tranexamic acid on death,<br />
vascular occlusive events, and blood transfusion in<br />
trauma patients with significant haemorrhage<br />
(CRASH-2): a randomised, placebo-controlled trial.<br />
Lancet 2010; 376:23-32.<br />
17. Coats T, Roberts I, Shakur H (2004) Antifibrinolytic<br />
drugs for acute traumatic injury. Cochrane Database<br />
Syst Rev CD004896 [LoE 1a]<br />
18. Cotton BA, Au BK, Nunez TC et al. (2009) Predefined<br />
massive transfusion protocols are associated with a<br />
reduction in organ failure and postinjury<br />
complications. J Trauma 66: 41-48 [LoE 3b]<br />
19. Cotton BA, Gunter OL, Isbell J et al. (2008) Damage<br />
control hematology: the impact of a trauma<br />
exsanguination protocol on survival and blood product<br />
utilization. J Trauma 64: 1177-1182<br />
20. Dara SI, Rana R, Afessa B et al. (2005) Fresh frozen<br />
plasma transfusion in critically ill medical patients<br />
with coagulopathy. Crit Care Med 33: 2667-2671<br />
[LoE 2b]<br />
21. Dente CJ, Shaz BH, Nicholas JM et al. (2009)<br />
Improvements in early mortality and coagulopathy are<br />
sustained better in patients with blunt trauma after<br />
institution of a massive transfusion protocol in a<br />
civilian level I trauma center. J Trauma 66: 1616-1624<br />
[LoE 2c]<br />
22. Dickneite G, Doerr B, Kaspereit F (2008)<br />
Characterization of the coagulation deficit in porcine<br />
dilutional coagulopathy and substitution with a<br />
prothrombin complex concentrate. Anesth Analg 106:<br />
1070-1077 [LoE 5]<br />
23. Dickneite G, Pragst I (2009) Prothrombin complex<br />
concentrate vs fresh frozen plasma for reversal of<br />
dilutional coagulopathy in a porcine trauma model. Br<br />
J Anaesth 102: 345-354 [LoE 5]<br />
24. Duchesne JC, Hunt JP, Wahl G et al. (2008) Review of<br />
current blood transfusions strategies in a mature level<br />
I trauma center: were we wrong for the last 60 years?<br />
J Trauma 65: 272-276 [LoE 3b]<br />
25. Duchesne JC, Mathew KA, Marr AB et al. (2008)<br />
Current evidence based guidelines for factor VIIa use<br />
in trauma: the good, the bad, and the ugly. Am Surg<br />
74: 1159-1165 [Evidenzbasierte Leitlinie]<br />
26. Dutton RP (2002) Hypotensive resuscitation during<br />
active hemorrhage: impact on in-hospital mortality -<br />
Leserbrief. J Trauma 52: 1196-1197<br />
27. Dutton RP, Conti BM (2009) The role of recombinantactivated<br />
factor VII in bleeding trauma patients. Curr<br />
Opin Anaesthesiol 22: 299-304<br />
28. Dutton RP, Mackenzie CF, Scalea TM (2002)<br />
Hypotensive resuscitation during active hemorrhage:<br />
impact on in-hospital mortality. J Trauma 52: 1141-<br />
1146 [LoE 2b]<br />
29. Etemadrezaie H, Baharvahdat H, Shariati Z et al.<br />
(2007) The effect of fresh frozen plasma in severe<br />
closed head injury. Clin Neurol Neurosurg 109: 166-<br />
171 [LoE 1b]<br />
Emergency room – Coagulation system 286
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
30. Farriols Danés A, Gallur Cuenca L, Rodríguez Bueno<br />
S et al. (2008) Efficacy and tolerability of human<br />
fibrinogen concentrate administration to patients with<br />
acquired fibrinogen deficiency and active or in highrisk<br />
severe bleeding. Vox Sang 94: 221-226 [LoE 3b]<br />
31. F<strong>eng</strong>er-Eriksen C, Lindberg-Larsen M, Christensen<br />
AQ et al. (2008) Fibrinogen concentrate substitution<br />
therapy in patients with massive haemorrhage and low<br />
plasma fibrinogen concentrations. Br J Anaesth 101:<br />
769-773 [LoE 3b]<br />
32. Franchini M (2007) The use of desmopressin as a<br />
hemostatic agent: a concise review. Am J Hematol 82:<br />
731-735<br />
33. Fries D, Haas T, Klingler A et al. (2006) Efficacy of<br />
fibrinogen and prothrombin complex concentrate used<br />
to reverse dilutional coagulopathy--a porcine model.<br />
Br J Anaesth 97: 460-467 [LoE 5]<br />
34. Fries D, Haas T, Salchner V et al. (2005)<br />
Gerinnungsmanagement beim <strong>Polytrauma</strong>.<br />
Anaesthesist 54: 137-144<br />
35. Fries D, Innerhofer P, Reif C et al. (2006) The effect of<br />
fibrinogen substitution on reversal of dilutional<br />
coagulopathy: an in vitro model. Anesth Analg 102:<br />
347-351 [LoE 5]<br />
36. Fries D, Innerhofer P, Schobersberger W (2009) Time<br />
for changing coagulation management in traumarelated<br />
massive bleeding. Curr Opin Anaesthesiol 22:<br />
267-274<br />
37. Gerlach R, Tolle F, Raabe A et al. (2002) Increased<br />
risk for postoperative hemorrhage after intracranial<br />
surgery in patients with decreased factor XIII activity:<br />
implications of a prospective study. Stroke 33: 1618-<br />
1623<br />
38. Godje O, Gallmeier U, Schelian M et al. (2006)<br />
Coagulation factor XIII reduces postoperative<br />
bleeding after coronary surgery with extracorporeal<br />
circulation. Thorac Cardiovasc Surg 54: 26-33<br />
39. Gonzalez EA, Moore FA, Holcomb JB et al. (2007)<br />
Fresh frozen plasma should be given earlier to patients<br />
requiring massive transfusion. J Trauma 62: 112-119<br />
[LoE 2c]<br />
40. Grundman C, Plesker R, Kusch M et al. (2005)<br />
Prothrombin overload causes thromboembolic<br />
complications in prothrombin complex concentrates:<br />
in vitro and in vivo evidence. Thromb Haemost 94:<br />
1338-1339<br />
41. Gunter OL, Jr., Au BK, Isbell JM et al. (2008)<br />
Optimizing outcomes in Damage Control<br />
resuscitation: identifying blood product ratios<br />
associated with improved survival. J Trauma 65: 527-<br />
534 [LoE 3b]<br />
42. Hardy JF (2004) Current status of transfusion triggers<br />
for red blood cell concentrates. Transfus Apher Sci<br />
31: 55-66<br />
43. Hardy JF, De MP, Samama M (2004) Massive<br />
transfusion and coagulopathy: pathophysiology and<br />
implications for clinical management. Can J Anaesth<br />
51: 293-310<br />
44. Hedin A, Hahn RG (2005) Volume expansion and<br />
plasma protein clearance during intravenous infusion<br />
of 5 % albumin and autologous plasma. Clin Sci<br />
(Lond) 108: 217-224 [LoE 4]<br />
45. Henry DA, Carless PA, Moxey AJ et al. (2007) Antifibrinolytic<br />
use for minimising perioperative<br />
allogeneic blood transfusion. Cochrane Database Syst<br />
Rev CD001886 [LoE 1a]<br />
46. Hess JR, Brohi K, Dutton RP et al. (2008) The<br />
coagulopathy of trauma: a review of mechanisms. J<br />
Trauma 65: 748-754<br />
47. Hess JR, Lawson JH (2006) The coagulopathy of<br />
trauma versus disseminated intravascular coagulation.<br />
J Trauma 60: S12-S19<br />
48. Hess JR, Lindell AL, Stansbury LG et al. (2009) The<br />
prevalence of abnormal results of conventional<br />
coagulation tests on admission to a trauma center.<br />
Transfusion 49: 34-39 [LoE 2b]<br />
49. Hiippala ST (1995) Dextran and hydroxyethyl starch<br />
interfere with fibrinogen assays. Blood Coagul<br />
Fibrinolysis 6: 743-746<br />
50. Hiippala ST, Myllyla GJ, Vahtera EM (1995)<br />
Hemostatic factors and replacement of major blood<br />
loss with plasma-poor red cell concentrates. Anesth<br />
Analg 81: 360-365<br />
51. Hirshberg A, Dugas M, Banez EI et al. (2003)<br />
Minimizing dilutional coagulopathy in exsanguinating<br />
hemorrhage: a computer simulation. J Trauma 54:<br />
454-463 [LoE 5]<br />
52. Ho AM, Dion PW, Ch<strong>eng</strong> CA et al. (2005) A<br />
mathematical model for fresh frozen plasma<br />
transfusion strategies during major trauma<br />
resuscitation with ongoing hemorrhage. Can J Surg<br />
48: 470-478 [LoE 5]<br />
53. Holcomb JB (2007) Damage control resuscitation. J<br />
Trauma 62: <strong>S3</strong>6-<strong>S3</strong>7<br />
54. Holcomb JB, Wade CE, Michalek JE et al. (2008)<br />
Increased plasma and platelet to red blood cell ratios<br />
improves outcome in 466 massively transfused<br />
civilian trauma patients. Ann Surg 248: 447-458 [LoE<br />
2b]<br />
55. Hoyt DB, Bulger EM, Knudson MM et al. (1994)<br />
Death in the operating room: an analysis of a multicenter<br />
experience. J Trauma 37: 426-432<br />
56. Hsia CC, Chin-Yee IH, McAlister VC (2008) Use of<br />
recombinant activated factor VII in patients without<br />
hemophilia: a meta-analysis of randomized control<br />
trials. Ann Surg 248: 61-68 [LoE 1a]<br />
57. Jacobs LM (1994) Timing of fluid resuscitation in<br />
trauma. N Engl J Med 331: 1153-1154<br />
58. Jambor C, Görlinger K (2007) Einsatz von<br />
Antifibrinolytika bei Massivtransfusionen. Anästh<br />
Intensivmed 48: S167-S173<br />
59. Jambor C, Heindl B, Spannagl M et al. (2009)<br />
Hämostaseologisches Management beim <strong>Polytrauma</strong> -<br />
Stellenwert der patientennahen diagnostischen<br />
Methoden. Anästhesiol Intensivmed Notfallmed<br />
Schmerzther 44: 200-210<br />
60. Kashuk JL, Moore EE, Johnson JL et al. (2008)<br />
Postinjury life threatening coagulopathy: is 1:1 fresh<br />
frozen plasma:packed red blood cells the answer? J<br />
Trauma 65: 261-270 [LoE 2c]<br />
Emergency room – Coagulation system 287
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
61. Kashuk JL, Moore EE, Millikan JS et al. (1982) Major<br />
abdominal vascular trauma--a unified approach. J<br />
Trauma 22: 672-679<br />
62. Korte W (2006) Fibrinmonomer und Faktor XIII.<br />
Neues Konzept bei ungeklärter intraoperativer<br />
Blutungsneigung. Hamostaseologie 26: <strong>S3</strong>0-<strong>S3</strong>5<br />
63. Korte WC, Szadkowski C, Gahler A et al. (2009)<br />
Factor XIII substitution in surgical cancer patients at<br />
high risk for intraoperative bleeding. Anesthesiology<br />
110: 239-245 [LoE 2b]<br />
64. Kozek-Langenecker S (2007) Monitoring hemostasis<br />
in emergency medicine. Yearb Intensive Care Emerg<br />
Med 848-859<br />
65. Kwan I, Bunn F, Roberts I (2003) Timing and volume<br />
of fluid administration for patients with bleeding.<br />
Cochrane Database Syst Rev CD002245 [LoE 1a]<br />
66. Lauzier F, Cook D, Griffith L et al. (2007) Fresh<br />
frozen plasma transfusion in critically ill patients. Crit<br />
Care Med 35: 1655-1659<br />
67. Levrat A, Gros A, Rugeri L et al. (2008) Evaluation of<br />
rotation thrombelastography for the diagnosis of<br />
hyperfibrinolysis in trauma patients. Br J Anaesth<br />
100: 792-797 [LoE 3b]<br />
68. Levy JH (2008) Pharmacologic methods to reduce<br />
perioperative bleeding. Transfusion 48: 31S-38S<br />
69. Lier H, Kampe S, Schroeder S (2007)<br />
Rahmenbedingungen für eine intakte Hämostase.<br />
Anaesthesist 56: 239-251<br />
70. Lier H, Krep H, Schöchl H (2009)<br />
Gerinnungsmanagement bei der<br />
<strong>Polytrauma</strong>versorgung. Anaesthesist 58: 1010-1026<br />
71. Lier H, Krep H, Schroeder S et al. (2008)<br />
Preconditions of hemostasis in trauma: a review. The<br />
influence of acidosis, hypocalcemia, anemia, and<br />
hypothermia on functional hemostasis in trauma. J<br />
Trauma 65: 951-960<br />
72. MacLeod JB, Lynn M, McKenney MG et al. (2003)<br />
Early coagulopathy predicts mortality in trauma. J<br />
Trauma 55: 39-44 [LoE 2b]<br />
73. Madjdpour C, Dettori N, Frascarolo P et al. (2005)<br />
Molecular weight of hydroxyethyl starch: is there an<br />
effect on blood coagulation and pharmacokinetics? Br<br />
J Anaesth 94: 569-576 [LoE 5]<br />
74. Maegele M (2009) Frequency, risk stratification and<br />
therapeutic management of acute post-traumatic<br />
coagulopathy. Vox Sang 97: 39-49<br />
75. Maegele M, Lefering R, Paffrath T et al. (2008) Redblood-cell<br />
to plasma ratios transfused during massive<br />
transfusion are associated with mortality in severe<br />
multiple injury: a retrospective analysis from the<br />
Trauma Registry of the Deutsche Gesellschaft fur<br />
Unfallchirurgie. Vox Sang 95: 112-119 [LoE 2c]<br />
76. Maegele M, Lefering R, Yucel N et al. (2007) Early<br />
coagulopathy in multiple injury: an analysis from the<br />
German Trauma Registry on 8724 patients. Injury 38:<br />
298-304 [LoE 3b]<br />
77. Malone DL, Dunne J, Tracy JK et al. (2003) Blood<br />
transfusion, independent of shock severity, is<br />
associated with worse outcome in trauma. J Trauma<br />
54: 898-905 [LoE 2c]<br />
78. Mannucci PM, Levi M (2007) Prevention and<br />
treatment of major blood loss. N Engl J Med 356:<br />
2301-2311<br />
79. Martini WZ (2009) Coagulopathy by hypothermia and<br />
acidosis: mechanisms of thrombin generation and<br />
fibrinogen availability. J Trauma 67: 202-208 [LoE 5]<br />
80. Martini WZ, Cortez DS, Dubick MA et al. (2008)<br />
Thrombelastography is better than PT, aPTT, and<br />
activated clotting time in detecting clinically relevant<br />
clotting abnormalities after hypothermia, hemorrhagic<br />
shock and resuscitation in pigs. J Trauma 65: 535-543<br />
[LoE 5]<br />
81. Martini WZ, Dubick MA, Pusateri AE et al. (2006)<br />
Does bicarbonate correct coagulation function<br />
impaired by acidosis in swine? J Trauma 61: 99-106<br />
[LoE 5]<br />
82. Martini WZ, Dubick MA, Wade CE et al. (2007)<br />
Evaluation of tris-hydroxymethylaminomethane on<br />
reversing coagulation abnormalities caused by<br />
acidosis in pigs. Crit Care Med 35: 1568-1574 [LoE<br />
5]<br />
83. McDonald V, Ryland K (2008) Coagulopathy in<br />
trauma: optimising haematological status. Trauma 10:<br />
109-123<br />
84. M<strong>eng</strong> ZH, Wolberg AS, Monroe DMI et al. (2003)<br />
The effect of temperature and pH on the activity of<br />
factor VIIa: implications for the efficacy of high-dose<br />
factor VIIa in hypothermic and acidotic patients. J<br />
Trauma 55: 886-891<br />
85. Mittermayr M, Streif W, Haas T et al. (2007)<br />
Hemostatic changes after crystalloid or colloid fluid<br />
administration during major orthopedic surgery: the<br />
role of fibrinogen administration. Anesth Analg 105:<br />
905-17 [LoE 2b]<br />
86. Nielsen VG (2005) Colloids decrease clot propagation<br />
and str<strong>eng</strong>th: role of factor XIII-fibrin polymer and<br />
thrombin-fibrinogen interactions. Acta Anaesthesiol<br />
Scand 49: 1163-1171<br />
87. Nishijima DK, Zehtabchi S (2009) The Efficacy of<br />
Recombinant Activated Factor VII in Severe Trauma.<br />
Ann Emerg Med 54: 737-744<br />
88. Nunez TC, Voskresensky IV, Dossett LA et al. (2009)<br />
Early prediction of massive transfusion in trauma:<br />
simple as ABC (assessment of blood consumption)? J<br />
Trauma 66: 346-352 [LoE 2b]<br />
89. Pereira A, del Valle OM, Sanz C (2003) DDAVP<br />
enhances the ability of blood monocytes to form<br />
rosettes with activated platelets by increasing the<br />
expression of P-selectin sialylated ligands on the<br />
monocyte surface. Br J Haematol 120: 814-820<br />
90. Perkins JG, Andrew CP, Spinella PC et al. (2009) An<br />
evaluation of the impact of apheresis platelets used in<br />
the setting of massively transfused trauma patients. J<br />
Trauma 66: S77-S84 [LoE 3b]<br />
91. Perkins JG, Schreiber MA, Wade CE et al. (2007)<br />
Early versus late recombinant factor VIIa in combat<br />
trauma patients requiring massive transfusion. J<br />
Trauma 62: 1095-1099 [LoE 3b]<br />
92. Plotkin AJ, Wade CE, Jenkins DH et al. (2008) A<br />
reduction in clot formation rate and str<strong>eng</strong>th assessed<br />
by thrombelastography is indicative of transfusion<br />
Emergency room – Coagulation system 288
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
requirements in patients with penetrating injuries. J<br />
Trauma 64: S64-S68 [LoE 3b]<br />
93. Repine TB, Perkins JG, Kauvar DS et al. (2006) The<br />
use of fresh whole blood in massive transfusion. J<br />
Trauma 60: S59-S69<br />
94. Rixen D, Raum M, Bouillon B et al. (2001)<br />
Prognoseabschätzung des Schwerverletzten – Eine<br />
Analyse von 2069 Patienten des Traumaregisters der<br />
<strong>DGU</strong>. Unfallchirurg 104: 230-239<br />
95. Rugeri L, Levrat A, David JS et al. (2007) Diagnosis<br />
of early coagulation abnormalities in trauma patients<br />
by rotation thrombelastography. J Thromb Haemost 5:<br />
289-295 [LoE 3b]<br />
96. Rundgren M, Engstrom M (2008) A<br />
thromboelastometric evaluation of the effects of<br />
hypothermia on the coagulation system. Anesth Analg<br />
107: 1465-1468 [LoE 5]<br />
97. Sagraves SG, Toschlog EA, Rotondo MF (2006)<br />
Damage control surgery--the intensivist's role. J<br />
Intensive Care Med 21: 5-16<br />
98. Samama CM (2008) Prothrombin complex<br />
concentrates: a brief review. Eur J Anaesthesiol 25:<br />
784-789<br />
99. Sarani B, Dunkman WJ, Dean L et al. (2008)<br />
Transfusion of fresh frozen plasma in critically ill<br />
surgical patients is associated with an increased risk of<br />
infection. Crit Care Med 36: 1114-1118 [LoE 3b]<br />
100. Scalea TM, Bochicchio KM, Lumpkins K et al.<br />
(2008) Early aggressive use of fresh frozen plasma<br />
does not improve outcome in critically injured trauma<br />
patients. Ann Surg 248: 578-584 [LoE 2b]<br />
101. Schochl H, Frietsch T, Pavelka M et al. (2009)<br />
Hyperfibrinolysis after major trauma: differential<br />
diagnosis of lysis patterns and prognostic value of<br />
thrombelastometry. J Trauma 67: 125-131 [LoE 3b]<br />
102. Schöchl H (2006) Gerinnungsmanagement bei<br />
<strong>Polytrauma</strong>. Hamostaseologie 26: S52-S55<br />
103. Shaz BH, Dente CJ, Harris RS et al. (2009)<br />
Transfusion management of trauma patients. Anesth<br />
Analg 108: 1760-1768<br />
104. Singbartl K, Innerhofer P, Radvan J et al. (2003)<br />
Hemostasis and hemodilution: a quantitative<br />
mathematical guide for clinical practice. Anesth<br />
Analg 96: 929-35 [LoE 5]<br />
105. Snyder CW, Weinberg JA, McGwin G, Jr. et al.<br />
(2009) The relationship of blood product ratio to<br />
mortality: survival benefit or survival bias? J Trauma<br />
66: 358-362 [LoE 2c]<br />
106. Spahn DR, Cerny V, Coats TJ et al. (2007)<br />
Management of bleeding following major trauma: a<br />
European guideline. Crit Care 11: R17<br />
[Evidenzbasierte Leitlinie]<br />
107. Spahn DR, Rossaint R (2005) Coagulopathy and<br />
blood component transfusion in trauma. Br J Anaesth<br />
95: 130-139<br />
108. Spahn DR, Tucci MA, Makris M (2005) Is<br />
recombinant FVIIa the magic bullet in the treatment<br />
of major bleeding? Br J Anaesth 94: 553-555<br />
109. Sperry JL, Ochoa JB, Gunn SR et al. (2008) An<br />
FFP:PRBC transfusion ratio >/=1:1.5 is associated<br />
with a lower risk of mortality after massive<br />
transfusion. J Trauma 65: 986-993 [LoE 2b]<br />
110. Spinella PC (2008) Warm fresh whole blood<br />
transfusion for severe hemorrhage: U.S. military and<br />
potential civilian applications. Crit Care Med 36:<br />
<strong>S3</strong>40-<strong>S3</strong>45<br />
111. Spinella PC, Holcomb JB (2009) Resuscitation and<br />
transfusion principles for traumatic hemorrhagic<br />
shock. Blood Rev 23: 231-240<br />
112. Spinella PC, Perkins JG, Grathwohl KW et al. (2008)<br />
Effect of plasma and red blood cell transfusions on<br />
survival in patients with combat related traumatic<br />
injuries. J Trauma 64: S69-S77 [LoE 3b]<br />
113. Spinella PC, Perkins JG, McLaughlin DF et al. (2008)<br />
The effect of recombinant activated factor VII on<br />
mortality in combat-related casualties with severe<br />
trauma and massive transfusion. J Trauma 64: 286-<br />
293 [LoE 3b]<br />
114. Stainsby D, MacLennan S, Hamilton PJ (2000)<br />
Management of massive blood loss: a template<br />
guideline. Br J Anaesth 85: 487-491<br />
115. Stanworth SJ, Birchall J, Doree CJ et al. (2007)<br />
Recombinant factor VIIa for the prevention and<br />
treatment of bleeding in patients without haemophilia.<br />
Cochrane Database Syst Rev CD005011 [LoE 1a]<br />
116. Stanworth SJ, Brunskill SJ, Hyde CJ et al. (2004) Is<br />
fresh frozen plasma clinically effective? A systematic<br />
review of randomized controlled trials. Br J Anaesth<br />
126: 139-152 [LoE 1a]<br />
117. Stein DM, Dutton RP, Kramer ME et al. (2009)<br />
Reversal of coagulopathy in critically ill patients with<br />
traumatic brain injury: recombinant factor VIIa is<br />
more cost-effective than plasma. J Trauma 66: 63-72<br />
[LoE 3b]<br />
118. Steuernagel,C. Bleeding Card. Erreichbar unter:<br />
http://www.card.haemostase.info/<br />
119. Stinger HK, Spinella PC, Perkins JG et al. (2008) The<br />
ratio of fibrinogen to red cells transfused affects<br />
survival in casualties receiving massive transfusions at<br />
an army combat support hospital. J Trauma 64: S79-<br />
S85 [LoE 3b]<br />
120. Tanaka KA, Taketomi T, Szlam F et al. (2008)<br />
Improved clot formation by combined administration<br />
of activated factor VII (NovoSeven) and fibrinogen<br />
(Haemocomplettan P). Anesth Analg 106: 732-738<br />
[LoE 5]<br />
121. Teixeira PG, Inaba K, Shulman I et al. (2009) Impact<br />
of plasma transfusion in massively transfused trauma<br />
patients. J Trauma 66: 693-697 [LoE 2c]<br />
122. The CRASH-2 Trial Collaborators (2006) Improving<br />
the evidence base for trauma care: Progress in the<br />
international CRASH-2 trial. PLoS Clin Trials 1: e30<br />
123. Theusinger OM, Spahn DR, Ganter MT (2009)<br />
Transfusion in trauma: why and how should we<br />
change our current practice? Curr Opin Anaesthesiol<br />
22: 305-312<br />
124. Tieu BH, Holcomb JB, Schreiber MA (2007)<br />
Coagulopathy: its pathophysiology and treatment in<br />
the injured patient. World J Surg. 31: 1055-1064<br />
Emergency room – Coagulation system 289
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
125. Tinmouth A, Fergusson D, Yee IC et al. (2006)<br />
Clinical consequences of red cell storage in the<br />
critically ill. Transfusion 46: 2014-2027<br />
126. Tsuei BJ, Kearney PA (2004) Hypothermia in the<br />
trauma patient. Injury 35: 7-15<br />
127. Turner J, Nicholl J, Webber L et al. (2000) A<br />
randomised controlled trial of prehospital intravenous<br />
fluid replacement therapy in serious trauma. Health<br />
Technol Assess 4: 1-57 [LoE 2b]<br />
128. Velik-Salchner C, Haas T, Innerhofer P et al. (2007)<br />
The effect of fibrinogen concentrate on<br />
thrombocytopenia. J Thromb Haemost 5: 1019-1025<br />
[LoE 5]<br />
129. Weeterings C, de Groot PG, Adelmeijer J et al.<br />
(2008) The glycoprotein Ib-IX-V complex contributes<br />
to tissue factor-independent thrombin generation by<br />
recombinant factor VIIa on the activated platelet<br />
surface. Blood 112: 3227-3233<br />
130. Weinberg JA, McGwin G, Jr., Griffin RL et al.<br />
(2008) Age of transfused blood: an independent<br />
predictor of mortality despite universal<br />
leukoreduction. J Trauma 65: 279-282<br />
131. Weinberg JA, McGwin G, Jr., Marques MB et al.<br />
(2008) Transfusions in the less severely injured: does<br />
age of transfused blood affect outcomes? J Trauma<br />
65: 794-798<br />
132. Weinkove R, Rangarajan S (2008) Fibrinogen<br />
concentrate for acquired hypofibrinogenaemic states.<br />
Transfus Med 18: 151-157 [LoE 2b]<br />
133. Wettstein P, Haeberli A, Stutz M et al. (2004)<br />
Decreased factor XIII availability for thrombin and<br />
early loss of clot firmness in patients with unexplained<br />
intraoperative bleeding. Anesth Analg 99: 1564-1569<br />
[LoE 3b]<br />
134. Williams TM, Sadjadi J, Harken AH et al. (2008) The<br />
necessity to assess anticoagulation status in elderly<br />
injured patients. J Trauma 65: 772-776<br />
135. Ying CL, Tsang SF, Ng KF (2008) The potential use<br />
of desmopressin to correct hypothermia-induced<br />
impairment of primary haemostasis-An in vitro study<br />
using PFA-100((R)). Resuscitation 76: 129-133 [LoE<br />
5]<br />
136. Yucel N, Lefering R, Maegele M et al. (2006)<br />
Trauma Associated Severe Hemorrhage (TASH)-<br />
Score: probability of mass transfusion as surrogate for<br />
life threatening hemorrhage after multiple trauma. J<br />
Trauma 60: 1228-1236 [LoE 2b]<br />
137. Zander R. Base Excess und Gerinnung. Erreichbar<br />
unter: http://www.physioklin.de/content/view/77/<br />
138. Zink KA, Sambasivan CN, Holcomb JB et al. (2009)<br />
A high ratio of plasma and platelets to packed red<br />
blood cells in the first 6 hours of massive transfusion<br />
improves outcomes in a large multicenter study. Am J<br />
Surg 197: 565-570 [LoE 2b]<br />
139. Zotz RB, Araba F, Bux I (2009) Desmopressin<br />
(DDAVP) for minimising perioperative allogenic<br />
blood transfusion: a stratified metaanalysis.<br />
Hamostaseologie 29: A53 [LoE 1a]<br />
Emergency room – Coagulation system 290
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
2.17 Interventional control of bleeding<br />
Key recommendations:<br />
If possible, embolization should be carried out on patients whose<br />
hemodynamics can be stabilized.<br />
A stent/a stent graft must be used if an intimal dissection, vessel tear, AV<br />
fistula, pseudoaneurysm or a traumatic aortic rupture is present.<br />
If a patient with unstable circulation has a ruptured iliac artery or distal<br />
abdominal aortic hernia, a balloon occlusion can be temporarily carried out<br />
for up to 60 minutes.<br />
If there is renewed bleeding after successful embolization, further treatment<br />
should also be interventional.<br />
Explanation:<br />
Indication for interventional treatment and decision algorithm<br />
GoR B<br />
GoR A<br />
GoR 0<br />
GoR B<br />
The basic requirement for carrying out interventional radiology to monitor bleeding should be<br />
the multi-slice CT scan (MSCT) with contrast agent. Generally, the source of bleeding can be<br />
identified using this examination. Embolization should only be considered if there is evidence of<br />
an active contrast agent extravasation in the MSCT as only then is there adequate prospect of a<br />
successful visualization of the source of bleeding and subsequent treatment. In particular,<br />
interventional treatment may be considered in the following injury patterns:<br />
� pelvic fractures with evidence of contrast agent extravasation in the MSCT<br />
� spinal fractures with clear contrast agent extravasation<br />
� injuries to the great vessels<br />
� parallel or supplementary to surgical control of bleeding<br />
Emergency room – Interventional control of bleeding 291
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Technical and personnel requirements<br />
Carrying out interventional treatment to control bleeding is only advisable if the following<br />
requirements are met:<br />
� A conditional stabilization of the patient must be possible under massive transfusion and<br />
intensive medical treatment.<br />
� The personnel requirements must be met in the form of physicians on site who are<br />
experienced in angiography.<br />
� Supplies of the required embolization materials and stents must be available.<br />
Before carrying out a radiologic intervention, which generally lasts between 30 and 60 minutes<br />
including transport to the angiography unit, it is essential to clarify whether the patient can be<br />
stabilized with transfusions up to the time of the intervention and for the period of the<br />
intervention, whether the bleeding is located in an area that is typically accessible for<br />
embolization, and whether other sources of bleeding (e.g., extensive craniofacial injuries with<br />
massive diffuse bleeding), which are responsible for the blood loss, have been excluded.<br />
Materials and techniques for interventional control of bleeding<br />
In interventional radiology, the following materials are available for interventional control of<br />
bleeding:<br />
� non-covered and covered stents<br />
� metal coils<br />
� detachable balloons<br />
� solid particles<br />
− polyvinyl alcohol (Contour ® )<br />
− gelatin foam (gel type)<br />
− microspheres (Embospheres ® )<br />
� liquid embolization materials<br />
− ethanol<br />
− tissue adhesives (Bucrylat ® )<br />
− occlusion gel (Ethiblock ® )<br />
Emergency room – Interventional control of bleeding 292
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The coils are available in different diameters, shapes, and l<strong>eng</strong>ths. They are particularly suitable<br />
for the precise embolization of severely bleeding vessels of larger diameter. The positioning of<br />
the coils can be very precise and dislocations are very rare.<br />
Contour particles are also available in different sizes between 100 and 500 µm and are<br />
particularly suitable for the treatment of diffuse bleeding from fracture zones. Which of the<br />
above-mentioned materials are to be used depends on the bleeding and the experience of the<br />
interventional radiologist and requires an individual decision adapted to the situation.<br />
The goal of every embolization must be to carry out treatment without damaging the tissue if<br />
possible. In so doing, attention should be given to maintaining residual perfusion in the<br />
downstream organs and keeping damage to downstream tissue to the minimum.<br />
The main indication for implanting a non-covered stent in trauma management is the presence of<br />
an intimal dissection. There is an indication to implant a stent coated with polytetrafluroethylene<br />
(PTFE), dacron or polyester in vessel tears, AV fistulas, pseudoaneurysms or traumatic aortic<br />
ruptures in order to cover the vessel leak.<br />
Temporary balloon occlusion is available as a last resort. This can take the form of an occlusion<br />
of the infrarenal abdominal aorta for 30-60 minutes either under DSA or CT monitoring or a<br />
more selective occlusion in the internal iliac artery. However, if there is severe bleeding from the<br />
proximal internal iliac artery, preference should be given to coils for primary embolization. The<br />
goal of temporary balloon occlusion is to permit restoration of central circulation in patients with<br />
maximum circulation instability and thus to extend the timeframe until surgical or interventional<br />
care.<br />
Planning interventional control of bleeding<br />
A full-body MSCT scan is routinely performed before carrying out a radiologic intervention for<br />
controlling bleeding. There is a proven standardized examination protocol for this. Besides the<br />
plain examination of head and spine, the MSCT examination consists of a contrast-enhanced<br />
examination of thorax, abdomen, and pelvis. The primary contrast-enhanced examination after<br />
intravenous administration of 120 ml contrast agent at an injection rate of 2 ml/sec has been<br />
proven for the examination of thorax, abdomen, and pelvis. The examination should be carried<br />
out 85 seconds after contrast agent administration has started. This process ensures that, firstly,<br />
there is good, homogeneous contrasting of the parenchymatous organs but, secondly, sufficiently<br />
good contrasting of the great vessels is still ensured. In children and in a body weight less than<br />
60 kg, the quantity of contrast agent and the flow rate should be adjusted appropriately (e.g.,<br />
child weighing 30 kg: 60 ml contrast agent, flow rate 1 ml/s, child weighing 15 kg: 30 ml<br />
contrast agent, flow rate 0.5 ml/s). The start delay for the scan should remain at 80-85 seconds.<br />
The MSCT is able to visualize minimal density gradients reliably. Thus, the MSCT allows<br />
differentiation between already coagulated blood (density values between 40 and 70 HU) and<br />
active bleeding (density values between 25 and 370 HU, mean value 132 HU) [7].<br />
Emergency room – Interventional control of bleeding 293
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Discussion<br />
Embolization of the pelvis<br />
Overall, the embolization of pelvic fractures is only seldom indicated as most patients with<br />
pelvic fractures are hemodynamically stable. According to a study by Agolini et al. [8], only 15<br />
patients (1.9%) required embolization out of 806 patients with pelvic fractures. Other authors<br />
give the rate of necessary embolizations at 3% [9].<br />
The management of patients with significant bleeding from pelvic fractures is very chall<strong>eng</strong>ing.<br />
In addition to arterial bleeding, venous bleeding also represents a big problem. Arterial bleeding<br />
can be stopped by arterial embolization. The resulting hematoma then acts as a tamponade and<br />
also contributes towards arresting the venous bleeding. It is surgical hemostasis in arterial<br />
bleeding that frequently fails [10, 11] as the tamponade effect of the hematoma is removed<br />
during access to the iliac arteries, and massive, uncontrollable venous bleeding can occur. Even<br />
if definite evidence is still lacking, there are clear signs from clinical experience that arterial<br />
embolization can help even in diffuse venous bleeding as the arterial forward flow is cut off.<br />
According to our experience, the evidence here of active contrast agent extravasation in the<br />
MSCT greatly assists the decision-making process. If the personnel and logistic requirements are<br />
in place, embolization should be considered if there is evidence of active, relevant contrast agent<br />
extravasation in the presence of a critical circulation situation. If the examination technique is<br />
appropriate, the quantity of contrast agent sufficient, and the start delay 80-85 seconds after<br />
contrast agent administration has started, the lack of evidence of contrast agent extravasation in<br />
the MSCT is generally a reliable indication that arterial embolization could not promise success.<br />
The studies by Agolini et al. [8] also showed that early embolization leads to a more favorable<br />
result with regard to mortality. Thus, in this study with an admittedly relatively small patient<br />
collective which was embolized, there was an advantage for mortality in the group that was<br />
embolized within 3 hours (mortality 14%) compared to the group embolized later (mortality<br />
75%).<br />
Embolization of the spleen<br />
Arterial embolizations in splenic injuries are carried out only in isolated cases, usually as an<br />
alternative to surgical interventions to preserve the spleen [12]. Selective embolization without<br />
subsequent surgery is successful in 87-95% of cases [3, 13]. Proximal embolizations of the lienal<br />
artery should be avoided due to the risk of massive abdominal wall or pancreatic infarction. In<br />
addition, proximal embolization of the lienal artery is often not suited to achieving permanent<br />
hemostasis due to a reduction in pressure in the intrasplenic vessels.<br />
Embolization of the liver<br />
Embolization of the hepatic artery can be successfully used in the management of post-traumatic<br />
bleeding [14, 15, 16], involving overall relatively small series. Patients with sustained bleeding<br />
after primary surgical hemostasis to the liver in particular should undergo angiography and, if<br />
necessary, be embolized to avoid another operation [17].<br />
Emergency room – Interventional control of bleeding 294
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
If there is renewed bleeding after successful embolization, further treatment should also be<br />
carried out by angiography. In addition to the improved surgical results, arterial embolization has<br />
contributed particularly to improving the outcome after traumatic hepatic injuries [18].<br />
Embolization of the kidneys<br />
Many kidney injuries can be treated conservatively. Avulsions to the vascular pedicle must be<br />
surgically managed within the first few hours in order to preserve renal function. Angiography is<br />
indicated if, during the MSCT, contrast agent extravasation could be visualized in the kidney or<br />
around the kidney. Hemorrhagic-induced extravasation of contrast agent must not be confused<br />
with a dense contrast agent collection, e.g., in a urinoma. The success of renal embolization<br />
depends on this being carried out rapidly and as selectively as possible. A proximal occlusion of<br />
the renal artery is only indicated when a nephrectomy is indicated due to the organ being<br />
damaged but this must only be done later when the patient is more stable. In any case, the search<br />
for pole vessels is important for the angiographic work-up of the traumatic kidney injury as these<br />
might also require embolization. Studies have shown that kidney embolization is successful as<br />
primary treatment in 82-100% of cases.<br />
Endovascular treatment of traumatic aortic rupture<br />
Numerous studies have been carried out during recent years on the value of endovascular<br />
treatment of traumatic aortic rupture [19–26]. Practically all come to the conclusion that in an<br />
acute situation preference should be given to endovascular treatment as opposed to the opensurgical<br />
procedure. Thus, Ott et al. [24] found evidence that the mortality and paraplegia rates in<br />
endovascular treatment are markedly better at 0% than the results of open-surgical treatment<br />
with a mortality of 17% and a paraplegia rate of 16%.<br />
Emergency room – Interventional control of bleeding 295
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Gruen G, Leit M, Gruen R, Peitzman A. The acute<br />
management of hemodynamically unstable multiple<br />
trauma patients with pelvic ring fractures. J Trauma<br />
1994; 36:706-711; discussion 711-703.<br />
2. Nix J, Costanza M, Daley B, Powell M, Enderson B.<br />
Outcome of the current management of splenic<br />
injuries. J Trauma 2001; 50:835-842.<br />
3. Hagiwara A, Yukioka T, Ohta S, Nitatori T, Matsuda<br />
H, Shimazaki S. Nonsurgical management of patients<br />
with blunt splenic injury: efficacy of transcatheter<br />
arterial embolization. AJR Am J Roentgenol 1996;<br />
167:159-166.<br />
4. Saidi A, Bocqueraz F, Descotes J, et al. Blunt kidney<br />
trauma: a ten-year experience. Prog Urol 2004;<br />
14:1125-1131.<br />
5. Gourlay D, Hoffer E, Routt M, Bulger E. Pelvic<br />
angiography for recurrent traumatic pelvic arterial<br />
hemorrhage. J Trauma 2005; 59:1168-1173;<br />
discussion 1173-1164.<br />
6. Siritongtaworn P. Management of life threatening<br />
hemorrhage from facial fracture. J Med Assoc Thai<br />
2005; 88:382-385.<br />
7. Shanmuganathan K, Mirvis S, Sover E. Value of<br />
contrast-enhanced CT in detecting active hemorrhage<br />
in patients with blunt abdominal or pelvic trauma.<br />
AJR Am J Roentgenol 1993; 161:65-69.<br />
8. Agolini S, Shah K, Jaffe J, Newcomb J, Rhodes M,<br />
Reed J. Arterial embolization is a rapid and effective<br />
technique for controlling pelvic fracture hemorrhage.<br />
J Trauma 1997; 43:395-399.<br />
9. Mucha P, Welch T. Hemorrhage in major pelvic<br />
fractures. Surg Clin North Am 1988; 68:757-773.<br />
10. Ben-Menachem Y, Coldwell D, Young J, Burgess A.<br />
Hemorrhage associated with pelvic fractures: causes,<br />
diagnosis, and emergent management. AJR Am J<br />
Roentgenol 1991; 157:1005-1014.<br />
11. Panetta T, Sclafani S, Goldstein A, Phillips T, Shaftan<br />
G. Percutaneous transcatheter embolization for<br />
massive bleeding from pelvic fractures. J Trauma<br />
1985; 25:1021-1029.<br />
12. Chuang V, Reuter S. Selective arterial embolization<br />
for the control of traumatic splenic bleeding. Invest<br />
Radiol 1975; 10:18-24.<br />
13. Sclafani S, Weisberg A, Scalea T, Phillips T, Duncan<br />
A. Blunt splenic injuries: nonsurgical treatment with<br />
CT, arteriography, and transcatheter arterial<br />
embolization of the splenic artery. Radiology 1991;<br />
181:189-196.<br />
14. Yao D, Jeffrey R, Mirvis S, et al. Using contrastenhanced<br />
helical CT to visualize arterial extravasation<br />
after blunt abdominal trauma: incidence and organ<br />
distribution. AJR Am J Roentgenol 2002; 178:17-20.<br />
15. Kos X, Fanchamps J, Trotteur G, Dondelinger R.<br />
Radiologic Damage Control: evaluation of a<br />
combined CT and angiography suite with a pivoting<br />
table. Cardiovasc Intervent Radiol 1999; 22:124-129.<br />
16. Inoguchi H, Mii S, Sakata H, Orita H, Yamashita S.<br />
Intrahepatic pseudoaneurysm after surgical hemostasis<br />
for a delayed hemorrhage due to blunt liver injury:<br />
report of a case. Surg Today 2001; 31:367-370.<br />
17. De Toma G, Mingoli A, Modini C, Cavallaro A, Stipa<br />
S. The value of angiography and selective hepatic<br />
artery embolization for continuous bleeding after<br />
surgery in liver trauma: case reports. J Trauma 1994;<br />
37:508-511.<br />
18. Richardson D, Franklin G, Lukan J, et al. Evolution in<br />
the management of hepatic trauma: a 25-year<br />
perspective. Ann Surg 2000; 232:324-330.<br />
19. Duncan I, Wright N, Fingleson L, Coetzee J.<br />
Immediate endovascular stent-graft repair of an acute<br />
traumatic rupture of the thoracic aorta: case report and<br />
subject review. S Afr J Surg 2004; 42:47-50.<br />
20. Lawlor D, Ott M, Forbes T, Kribs S, Harris K, De<br />
RG. Endovascular management of traumatic thoracic<br />
aortic injuries. Can J Surg 2005; 48:293-297.<br />
21. Verdant A. Endovascular management of traumatic<br />
aortic injuries. Can J Surg 2006; 49:217; author reply<br />
217-218.<br />
22. Orend K, Pamler R, Kapfer X, Liewald F, Gorich J,<br />
Sunder-Plassmann L. Endovascular repair of<br />
traumatic descending aortic transection. J Endovasc<br />
Ther 2002; 9:573-578.<br />
23. Amabile P, Collart F, Gariboldi V, Rollet G, Bartoli J,<br />
Piquet P. Surgical versus endovascular treatment of<br />
traumatic thoracic aortic rupture. J Vasc Surg 2004;<br />
40:873-879.<br />
24. Ott M, Stewart T, Lawlor D, Gray D, Forbes T.<br />
Management of blunt thoracic aortic injuries:<br />
endovascular stents versus open repair. J Trauma<br />
2004; 56:565-570.<br />
25. Lin P, Bush R, Zhou W, Peden E, Lumsden A.<br />
Endovascular treatment of traumatic thoracic aortic<br />
injury--should this be the new standard of treatment? J<br />
Vasc Surg 2006; 43 Suppl A:22A-29A.<br />
26. Dunham M, Zygun D, Petrasek P, Kortbeek J, Karmy-<br />
Jones R, Moore R. Endovascular stent grafts for acute<br />
blunt aortic injury. J Trauma 2004; 56:1173-1178.<br />
Emergency room – Interventional control of bleeding 296
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3 Emergency surgery phase<br />
3.1 Introduction<br />
How would you decide?<br />
A 35-year-old cyclist has an accident. The patient is intubated and ventilated at the accident<br />
scene by the emergency physician. Volume replacement to support circulation is introduced. The<br />
patient is brought to you for primary management. After exclusion of relevant intraabdominal or<br />
intrathoracic bleeding and after a thorough diagnostic study, the following injury pattern<br />
manifests itself: traumatic brain injury II °, chest trauma with multiple rib fracture and<br />
pronounced left pulmonary contusion, I ° left open femoral shaft fracture, right distal lower leg<br />
fracture. The laboratory tests initially carried out show a hemoglobin value of 9.3 g/dl, INR of<br />
77%, and a base excess of - 4.5 mmol/l.<br />
You consider what care options exist in the first surgical phase for this patient and weigh up their<br />
advantages and disadvantages. The longer you think about it, the more questions arise: What is<br />
the first-line choice of surgery strategy for the femoral shaft fracture? Which care strategy is best<br />
for the distal lower leg fracture? Does the fibula have to be managed at the same time? Is<br />
primary definitive osteosynthesis sensible or is temporary osteosynthesis better? What role does<br />
the traumatic brain injury or the chest trauma play in the decision-making? You remember the<br />
management of similar cases in your department, the dogmatically repeated ideas of your<br />
“teacher” or other colleagues, the economic “restraints” of your hospital administration, and the<br />
perennial lack of time to deal properly for once with the almost limitless complex literature on<br />
polytrauma management. In the end, you opt once more to carry out the care based on your own<br />
experiences.<br />
How would other providers in Germany decide?<br />
By way of example, we will focus on the question of femoral shaft management. According to<br />
the available data in the trauma registry of the German Trauma Society, more than 65% of all<br />
multiple injuries involve injuries to the extremities and/or the pelvis (AIS > 2). It is, therefore, all<br />
the more astonishing that contradictory surgical management strategies for femoral shaft<br />
fractures in polytrauma are practiced and published [1]. According to analyses of the trauma<br />
registry, the primary management of femoral shaft fractures in multiply injured patients in<br />
Germany is, almost dogmatically, always with an external fixator in some hospitals, always with<br />
a medullary nail in other hospitals, and <strong>final</strong>ly in many hospitals, in every conceivable<br />
combination, sometimes with fixators and sometimes with nails [1].<br />
The aim of this “emergency surgery phase” guideline section<br />
Such depictions of “reality” refer to an alternative, often even contradictory range of decisions<br />
from different hospitals. They support the need for an overview of the evidence levels and grades<br />
of recommendation of differing management strategies. Thus, the aim of this section of the<br />
guideline is to gain an overview of the evidence levels of different management strategies in the<br />
emergency surgery phase after multiple injury, and from this either to derive clinical treatment<br />
Emergency surgery phase - Introduction 297
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
algorithms (if there is sufficient evidence) or to document the need for scientific verification of<br />
the evidence (grade of recommendation).<br />
Special notes:<br />
In this guideline section, the assessment of core questions is often hampered by the lack of<br />
“hard”, scientifically based data or by only results on mono-injuries being available. In this<br />
regard, the corresponding locations are explicitly referred to and attempts are made, despite the<br />
partly contradictory information from the literature, to provide the clearest possible<br />
recommendations for clinical routine in individual key recommendations.<br />
Moreover, in terms of fracture discussions, the initial assumption, if not explicitly mentioned<br />
elsewhere, is a closed fracture without vascular involvement and with no compartment<br />
syndrome. The open fracture, vascular involvement, and compartment syndrome are regarded as<br />
an indication for emergency surgery and require, if necessary, a different management strategy.<br />
In addition, in many surgically demanding fractures (e.g., distal complex femur or humerus<br />
condyle fracture), particularly in polytrauma, it should be taken into account that primary<br />
definitive care can only be considered if: a) careful planning has been carried out (if appropriate,<br />
on the basis of 3D CT); b) the expected duration of surgery is not too long; c) an experienced<br />
surgeon is present; d) a suitable implant is in stock in the hospital. For this reason, in many<br />
German trauma centers, such surgically demanding fractures in the multiply injured patient<br />
ought first to receive primary temporary stabilization before subsequently undergoing secondary<br />
definitive reconstruction.<br />
Finally, it is assumed hereafter that the patient has otherwise stable circulation with additional<br />
injuries of the extremities. The management strategy for a patient with multiple injuries and<br />
cardiopulmonary, metabolic, or coagulatory “instability” may be very different from this,<br />
depending on different priorities. Please refer to the relevant literature [1–7] for a risk assessment<br />
of the multiply injured patient as a decision aid in the management strategy. Damage control is a<br />
strategy for management of severely injured patients with the goal of minimizing secondary<br />
damage and maximizing the outcome for the patient. In the area of fracture treatment, for<br />
example, this would mean not carrying out primary definitive osteosynthesis but instead<br />
stabilizing the fracture temporarily with an external fixator. The smaller intervention and the<br />
shorter surgery time are intended to make it possible to limit the additional trauma burden to the<br />
maximum possible extent in terms of secondary damage. In precisely this respect, it must<br />
therefore be emphasized that individual biologic requirements (e.g., age), overall injury severity,<br />
but also additional severe injuries (e.g., severe traumatic brain injury), required surgery time,<br />
compensated dysfunctions in vital parameters (borderline patients), and the physiologic status of<br />
the patient (metabolism, coagulation, temperature, etc.) should also be included in the decisionmaking.<br />
Emergency surgery phase - Introduction 298
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Rixen D, Grass G, Sauerland S, Lefering R, Raum<br />
MR, Yücel N, Bouillon B, Neugebauer EAM, and the<br />
„<strong>Polytrauma</strong> Study Group“ of the German Trauma<br />
Society (2005) Evaluation of criteria for temporary<br />
external fixation in risk-adapted Damage Control<br />
orthopaedic surgery of femur shaft fractures in<br />
multiple trauma patients: “evidence based medicine”<br />
versus “reality” in the trauma registry of the German<br />
Trauma Society. J Trauma 59:1375-1395<br />
2. Giannoudis PV (2003) Surgical priorities in Damage<br />
Control in polytrauma. J Bone Joint Surg (Br) 85:<br />
478-483<br />
3. Pape H, Stalp M, Dahlweid M, Regel G, Tscherne H,<br />
Arbeitsgemeinschaft „<strong>Polytrauma</strong>“ der Deutschen<br />
Gesellschaft für Unfallchirurgie (1999) Welche<br />
primäre Operationsdauer ist hinsichtlich eines<br />
„Borderline-Zustandes“ polytraumatisierter Patienten<br />
vertretbar? Unfallchirurg 102: 861-869<br />
4. Pape HC, van Griensven M, Sott AH, Giannoudis P,<br />
Morley J, Roise O, Ellingsen E, Hildebrand F, Wiese<br />
B, Krettek C, EPOFF study group (2003) Impact of<br />
intramedullary instrumentation versus Damage<br />
Control for femoral fractures on immunoinflammatory<br />
parameters: prospective randomized analysis by the<br />
EPOFF study group. J Trauma 55: 7-13<br />
5. Scalea TM, Boswell SA, Scott JD, Mitchell KA,<br />
Kramer ME, Pollak AN (2000) External fixation as a<br />
bridge to intramedullary nailing for patients with<br />
multiple injuries and with femur fractures: Damage<br />
Control orthopedics. J Trauma 48: 613-623<br />
6. Bouillon B, Rixen D, Maegele M, Steinhausen E,<br />
Tjardes T, Paffrath T (2009) Damage control<br />
orthopedics – was ist der aktuelle Stand?<br />
Unfallchirurg 112:860–869<br />
7. Pape HC, Rixen D, Morley J, Husebye EE, Mueller<br />
M, Dumont C, Gruner A,Oestern HJ, Bayeff-Filoff M,<br />
Garving C, Pardini D, van Griensven M, Krettek C,<br />
Giannoudis P and the EPOFF study group (2007)<br />
Impact of the method of initial stabilization for<br />
femoral shaft fractures in patients with multiple<br />
injuries at risk for complications (borderline patients).<br />
Ann Surg 246:491-501<br />
Emergency surgery phase - Introduction 299
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.2 Thorax<br />
Surgical approach route<br />
Key recommendation:<br />
Depending on the injury location, an anterolateral thoracotomy, a<br />
posterolateral thoracotomy or a sternotomy can be selected. If the injury<br />
location is unclear, the clamshell approach may be selected.<br />
Explanation:<br />
GoR 0<br />
The standard approach is the anterolateral or posterolateral thoracotomy on the injury side at the<br />
level of the 4th-6th intercostal space. If a bilateral chest injury is suspected, a bilateral<br />
anterolateral thoracotomy or a clamshell thoracotomy can be performed. If the injury can be<br />
located precisely, the appropriate approaches are used, e.g., posterolateral approach for<br />
interventions to the thoracic aorta or a higher intercostal approach for injuries to the subclavian<br />
vessels or to the intrathoracic trachea [8, 17, 51, 52].<br />
The anterolateral thoracotomy appears to provide insufficient exposure of the injured organs in<br />
up to 20% of cases [25]. If required, this approach can thus be enlarged in the posterior direction<br />
or into a flap approach [51].<br />
The median sternotomy is preferred for injuries to the heart, the ascending aorta, and the aortic<br />
arch as well as injuries to the great vessels [25, 50, 51].<br />
In trauma surgery practice, the thoracoscopy is unsuitable in life-threatening emergencies. The<br />
video-based thoracoscopy can be used for the diagnostic work-up of diaphragm injuries or in the<br />
search for sources of bleeding but also for performing smaller interventions such as draining a<br />
hemothorax, etc. [17, 33, 51].<br />
Emergency surgery phase - Thorax 300
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Penetrating chest injuries<br />
Key recommendation:<br />
If there are perforating chest injuries, embedded foreign bodies should only be<br />
removed during surgery under controlled conditions after opening up the<br />
chest.<br />
Explanation:<br />
GoR B<br />
If it can be assumed that the chest has been perforated, foreign bodies penetrating the chest must<br />
not be removed due to a possible tamponade effect. Removal is always performed during surgery<br />
via an exploratory thoracotomy. The airtight closure or bandaging of puncture openings is also<br />
contraindicated because it prevents the pleural space from being decompressed. In complicated<br />
injuries, the goal should be a two-step closure of the chest wall after thorough lavage and<br />
generous wound debridement to avoid septic complications [51].<br />
Indication for thoracotomy<br />
Key recommendations:<br />
A penetrating chest injury, which is the cause of hemodynamic instability in<br />
the patient, must undergo an immediate exploratory thoracotomy.<br />
A thoracotomy can be performed if there is an initial blood loss of > 1,500 ml<br />
from the chest drain or if there is persistent blood loss of > 250 ml/h over more<br />
than 4 hours.<br />
Explanation:<br />
GoR A<br />
GoR 0<br />
The indication for immediate thoracotomy in penetrating injuries arises if the following are<br />
already present on admission to the emergency room: severe hemodynamic shock states, signs of<br />
pericardial tamponade, diffuse bleeding, absence of peripheral pulses, and cardiac arrest [2–4,<br />
17, 25, 32, 51]. Hemodynamically stable patients can be monitored after insertion of a chest<br />
drain or can undergo further diagnostic tests such as helical CT.<br />
Studies during the Vietnam War showed a reduction in mortality and the complication rate in<br />
predominantly penetrating injuries with a thoracotomy performed after a blood loss of initially<br />
> 1,500 ml or exceeding 500 ml in the first hour after drain insertion [32].<br />
In a multicenter study, there was evidence also of the dependence of mortality on thoracic blood<br />
loss irrespective of the mechanism of injury (blunt versus penetrating). Mortality rose here by a<br />
factor of 3.2 in the group with a blood loss of more than 1,500 ml in the first 24 hours compared<br />
with a blood loss from the chest drain of 500 ml/24 h. The mean time for performing the<br />
Emergency surgery phase - Thorax 301
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
thoracotomy was 2.4 ± 5.4 hours after admission [24]. Other authors agree with the strategy of<br />
performing a thoracotomy for blunt or penetrating injuries after an initial blood loss of 1,500 ml<br />
or with continuous bleeding of 250 ml/h over 4 hours [12, 24, 29, 32, 50]. If the drainage volume<br />
per time unit is used as an indication criterion for thoracotomy, this requires the drains to be<br />
correctly positioned and have reliable patency [51].<br />
In the case of a combination thoracic injury with high blood loss and marked metabolic<br />
derangement, a temporary chest closure consistent with damage control surgery can be carried<br />
out after acute management with controlling of bleeding. After stabilization of the patient in<br />
intensive care, the definitive surgical management and chest closure is carried out later [12, 19,<br />
22, 50].<br />
Lung injuries<br />
Key recommendation:<br />
If an indication for surgery exists for lung injuries (persistent bleeding and/or<br />
air leak), the intervention should be parenchymal-sparing.<br />
Explanation:<br />
GoR B<br />
Lung parenchymal injuries in a penetrating or blunt chest trauma with persistent bleeding and/or<br />
air leak require surgical management [16, 17, 51]. One of the main indicators for an exploratory<br />
thoracotomy is marked or persistent bleeding (1,500 ml initially or 500 ml/h) [24]. If necessary,<br />
appropriate surgical management of possible lung parenchymal injuries is then indicated for<br />
hemostasis. Compared to parenchymal-sparing surgical procedures such as oversewing,<br />
tractotomy, atypical resection or segment resection, the lobectomy and pneumonectomy carry a<br />
higher complication and mortality rate [12, 19, 22, 30, 50]. At the same time, blunt injuries<br />
appear to be associated with a worse prognosis with regard to number of days in situ,<br />
complications, and mortality [30].<br />
Emergency surgery phase - Thorax 302
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Great vessel injuries<br />
Key recommendations:<br />
In the case of aortic ruptures, preference should be given over open<br />
revascularization procedures to implantation of an endostent graft if<br />
technically and anatomically possible.<br />
A systolic blood pressure of 90-120 mmHg should be set until reconstruction<br />
of the aorta or if under conservative management.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
The treatment for an aortic rupture traditionally consists of aortic reconstruction by direct suture<br />
with clamping of the aorta and using different bypass procedures to perfuse the lower body half<br />
and spinal cord during the clamping phase (left heart bypass, Gott shunt, heart-lung machine) [1,<br />
11, 18, 28, 31, 35, 42, 50].<br />
Current studies identify acute stenting for aortic ruptures as a minimally invasive, time-saving<br />
treatment option with minimal access damage [1, 36]. Complications such as cerebral or spinal<br />
hypoperfusion with corresponding late complications such as paraplegia occur less often. In the<br />
long term, anticoagulation as required in most bypass procedures can be dispensed with [6, 9, 14,<br />
37, 47]. Also in a current meta-analysis which compares open aortic reconstruction with<br />
endovascular stenting, evidence was found of a significantly lower mortality rate and a<br />
significantly lower rate of post-operative neurologic deficits (paraplegia, strokes) with the same<br />
technical success rate for endovascular stenting [37]. However, there are to date no data on longterm<br />
survival after endovascular aortic reconstruction [21, 41]. Overall, according to the<br />
literature currently available, the implantation of an endostent graft appears to be preferable to<br />
the conventional procedure [15].<br />
Complications such as paraplegia and acute kidney failure due to the open procedure are the<br />
result of operative-induced ischemia. The complication rate correlates with the aortic clamping<br />
time [23, 45].<br />
If perfusion is maintained during bypass procedure surgery instead of clamping the aorta, the<br />
complication rate is reduced (paraplegia, kidney failure) [10, 11, 16, 35].<br />
The hemodynamic status of the patient at the time of admission determines the timing for<br />
management of the aortic rupture. Patients in a hemodynamically unstable condition or in<br />
extremis must undergo surgery immediately [10]. In patients with concomitant traumatic brain<br />
injury, severe abdominal or skeletal injuries which require immediate surgery and in elderly<br />
patients with extensive cardiac and pulmonary comorbidities, the aortic injury can be managed<br />
with delayed urgency after treatment of additional life-threatening injuries and/or after<br />
stabilization [28, 50, 51]. In a series of 395 patients, Camp et al. showed that in<br />
hemodynamically stable patients the mortality was not significantly increased in non-urgent (> 4<br />
Emergency surgery phase - Thorax 303
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
hours) or delayed surgery (> 24 hours) compared to emergency surgery (< 4 hours) [10]. Other<br />
authors agree with this opinion [10, 15, 16, 45]. Delays of up to 2 months are tolerated in some<br />
cases [39].<br />
If surgery is not carried out as an emergency, strict pharmacologic control of blood pressure<br />
(systolic blood pressure between 90 and 120 mmHg and heart rate < 100/min) is required with<br />
beta blockers and vasodilators [15, 16].<br />
Cardiac injuries<br />
Life-threatening cardiac injuries occur primarily due to penetrating trauma. Injuries to several<br />
chambers are particularly associated with high mortality [2, 3, 17, 51]. An intrathoracic injury to<br />
the inferior vena cava often causes a life-threatening pericardial tamponade. The surgical<br />
management of the vein is carried out after pericardial decompression via the right atrium by<br />
means of a direct suture or with a patch closure using extracorporeal circulation [49–52].<br />
The approach is via a median sternotomy or, in the case of absolute urgency, by a left<br />
anterolateral thoracotomy. After decompression of the cardiac tamponade, which is present in<br />
more than 50% of cases, via a longitudinal incision of the pericardium, bleeding must be quickly<br />
controlled by staple or suture. After removal of the clamp from the bleeding atrial wall, this can<br />
be closed with a direct suture [34]. Ventricle lesions are closed by means of a pericardial patch<br />
or Teflon felt augmentation. Finally, the pericardial incision is adjusted by loosening to avoid a<br />
retamponade [2, 3, 17, 51]. Injuries that do not require an immediate thoracotomy are isolated<br />
septal defects, valve injuries or ventricle aneurysms [34].<br />
Proximal lesions of the coronary vessels must be reconstructed or in an emergency managed<br />
with a coronary artery bypass using a heart-lung machine. Distal lesions of the coronaries can be<br />
ligated [17, 51].<br />
The patient’s cardiac rhythm and cardiorespiratory function on arrival in the emergency room are<br />
important factors in prognosis [2, 3]. At all times, attempts must therefore be made to maintain<br />
cardiac pump function and treat cardiac arrhythmias as this lowers mortality [2, 3].<br />
Emergency surgery phase - Thorax 304
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Injuries of the tracheobronchial system<br />
Key recommendations:<br />
If there is clinical suspicion of an injury to the tracheobronchial system, a<br />
bronchoscopy should be carried out to confirm the diagnosis.<br />
Traumatic injuries to the tracheobronchial system should be surgically<br />
managed early following the diagnosis.<br />
In the case of localized injuries to the tracheobronchial system, conservative<br />
treatment can be attempted.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
GoR 0<br />
Injuries to the tracheobronchial system are rare and there is often a delay in making the diagnosis<br />
[5, 7, 26, 40, 44]. Occasionally, tracheobronchial injuries also occur as a complication in<br />
orotracheal intubation [43]. Penetrating injuries predominantly affect the cervical trachea<br />
whereas blunt injuries usually give rise to intrathoracic injuries. The right main bronchus in the<br />
immediate vicinity of the carina is affected more often [7, 26, 40]. If there are persistent<br />
pneumothoraces despite a functioning chest drain and despite the presence of soft tissue<br />
emphysema or atelectases, a tracheobronchoscopy should be performed to confirm the suspected<br />
diagnosis of a tracheobronchial injury [5, 7, 26, 27, 40]. Fiberoptic intubation with placement of<br />
the cuff distal to the defect can be directly connected to secure the airway. In a retrospective<br />
study, Kummer et al. established that a large number of patients require a definitive airway<br />
(tracheostomy) [27]. The emphasis here was on penetrating injuries. Surgical management of the<br />
tracheobronchial system should be carried out as soon as possible after making the diagnosis as<br />
delayed management is associated with an increased complication rate [7, 13, 26, 34, 40].<br />
Surgical management of airway injuries is associated with a markedly lower mortality compared<br />
to conservative treatment [7, 26, 40]. Conservative treatment should be considered after<br />
bronchoscopic inspection only in patients with small bronchial tissue defects (defect smaller than<br />
1/3 of the bronchial circumference) and well adapted bronchial margins [7, 13, 26, 34, 40]. In a<br />
retrospective study, Schneider and colleagues found no difference between the conservative and<br />
the surgical method in iatrogenic tracheal injuries without ventilation disorders and superficial or<br />
covered tracheal tears [43].<br />
Cervical injuries are managed by a collar incision. A right-sided posterolateral thoracotomy<br />
should be performed in the 4th-5th ICS as an approach to intrathoracic tracheal injuries [5, 7, 26,<br />
34, 40]. In simple transverse tears, tension-free end-to-end anastomosis of the bronchus is<br />
performed after its immobilization and, if necessary, resection of the cartilaginous bridge. If a<br />
direct suture is not possible, longitudinal tears with a defective formation of the membrane wall<br />
are closed with a patch to avoid bronchial stenoses developing [7, 26, 34, 40]. Managing the<br />
tracheobronchial injuries with a stent appears to have no role to play according to current<br />
literature.<br />
Emergency surgery phase - Thorax 305
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Injuries to the bony thorax (excluding spine)<br />
Key recommendation:<br />
The majority of injuries to the bony thorax including flail chest should be<br />
conservatively treated.<br />
Explanation:<br />
GoR B<br />
The vast majority of multiple rib fractures with an unstable thorax can be non-surgically treated<br />
by internal pneumatic splinting, CPAP (continuous positive airway pressure) ventilation,<br />
sensible bronchial toilet, and adequate pain therapy [38, 48]. Surgical treatment should be<br />
considered in patients with persistent respiratory insufficiency due to chest instability despite<br />
existing ventilation, in patients with extensive chest wall defects, and flail chest with threatening<br />
intrathoracic injury [38, 46, 48]. Voggenreiter et al. showed that primary surgical stabilization of<br />
multiple rib fractures with flail chest and respiratory insufficiency without pulmonary contusion<br />
has better results with a shorter ventilation period or a lower complication rate than conservative<br />
treatment. However, patients with a marked pulmonary contusion do not gain from surgical<br />
stabilization of the bony thorax [50].<br />
In a prospective randomized study of surgically managed multiple rib fractures in patients with<br />
flail chest and respiratory insufficiency, Tanaka et al. found evidence of a shorter ventilation<br />
time, a shorter stay in the intensive care unit, and a lower complication rate in the group<br />
surgically stabilized with Judet clamps compared to the control group who received internal<br />
pneumatic splints [46].<br />
Emergency surgery phase - Thorax 306
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Amabile P, Collart F, Gariboldi V et al. (2004)<br />
Surgical versus endovascular treatment of traumatic<br />
thoracic aortic rupture. J Vasc Surg 40:873-879 [LoE<br />
4]<br />
2. Asensio Ja, Berne Jd, Demetriades D et al. (1998) One<br />
hundred five penetrating cardiac injuries: a 2-year<br />
prospective evaluation. J Trauma 44:1073-1082 [LoE<br />
2b]<br />
3. Asensio Ja, Murray J, Demetriades D et al. (1998)<br />
Penetrating cardiac injuries: a prospective study of<br />
variables predicting outcomes. J Am Coll Surg<br />
186:24-34 [LoE 2b]<br />
4. Athanasiou T, Krasopoulos G, Nambiar P et al. (2004)<br />
Emergency thoracotomy in the pre-hospital setting: a<br />
procedure requiring clarification. Eur J Cardiothorac<br />
Surg 26:377-386 [LoE 2b]<br />
5. Ayed Ak, Al-Shawaf E (2004) Diagnosis and<br />
treatment of traumatic intrathoracic major bronchial<br />
disruption. Injury 35:494-499 [LoE 2b]<br />
6. Baguley Cj, Sibal Ak, Alison Pm (2005) Repair of<br />
injuries to the thoracic aorta and great vessels:<br />
Auckland, New Zealand 1995-2004. ANZ J Surg<br />
75:383-387 [LoE 2b]<br />
7. Balci Ae, Eren N, Eren S et al. (2002) Surgical<br />
treatment of post-traumatic tracheobronchial injuries:<br />
14-year experience. Eur J Cardiothorac Surg 22:984-<br />
989 [LoE 4]<br />
8. Branney Sw, Moore Ee, Feldhaus Km et al. (1998)<br />
Critical analysis of two decades of experience with<br />
postinjury emergency department thoracotomy in a<br />
regional trauma center. J Trauma 45:87-94; discussion<br />
94-85 [LoE 4]<br />
9. Buz S, Zipfel B, Mulahasanovic S et al. (2008)<br />
Conventional surgical repair and endovascular<br />
treatment of acute traumatic aortic rupture. Eur J<br />
Cardiothorac Surg 33:143-149 [LoE 4]<br />
10. Camp Pc, Shackford Sr (1997) Outcome after blunt<br />
traumatic thoracic aortic laceration: identification of a<br />
high-risk cohort. Western Trauma Association<br />
Multicenter Study Group. J Trauma 43:413-422 [LoE<br />
3b]<br />
11. Cardarelli Mg, Mclaughlin Js, Downing Sw et al.<br />
(2002) Management of traumatic aortic rupture: a 30year<br />
experience. Ann Surg 236:465-469; discussion<br />
469-470 [LoE 2b]<br />
12. Cothren C, Moore Ee, Biffl Wl et al. (2002) Lungsparing<br />
techniques are associated with improved<br />
outcome compared with anatomic resection for severe<br />
lung injuries. J Trauma 53:483-487 [LoE 4]<br />
13. Dienemann H, Hoffmann H (2001) [Tracheobronchial<br />
injuries and fistulas]. Chirurg 72:1131-1136 [LoE 4]<br />
14. Dunham Mb, Zygun D, Petrasek P et al. (2004)<br />
Endovascular stent grafts for acute blunt aortic injury.<br />
J Trauma 56:1173-1178 [LoE 4]<br />
15. Fabian Tc, Davis Ka, Gavant Ml et al. (1998)<br />
Prospective study of blunt aortic injury: helical CT is<br />
diagnostic and antihypertensive therapy reduces<br />
rupture. Ann Surg 227:666-676; discussion 676-667<br />
[LoE 2b]<br />
16. Fabian Tc, Richardson Jd, Croce Ma et al. (1997)<br />
Prospective study of blunt aortic injury: Multicenter<br />
Trial of the American Association for the Surgery of<br />
Trauma. J Trauma 42:374-380; discussion 380-373<br />
[LoE 4]<br />
17. Feliciano Dv, Rozycki Gs (1999) Advances in the<br />
diagnosis and treatment of thoracic trauma. Surg Clin<br />
North Am 79:1417-1429 [LoE 4]<br />
18. Fujikawa T, Yukioka T, Ishimaru S et al. (2001)<br />
Endovascular stent grafting for the treatment of blunt<br />
thoracic aortic injury. J Trauma 50:223-229 [LoE 4]<br />
19. Gasparri M, Karmy-Jones R, Kralovich Ka et al.<br />
(2001) Pulmonary tractotomy versus lung resection:<br />
viable options in penetrating lung injury. J Trauma<br />
51:1092-1095; discussion 1096-1097 [LoE 4]<br />
20. Go Mr, Barbato Je, Dillavou Ed et al. (2007) Thoracic<br />
endovascular aortic repair for traumatic aortic<br />
transection. J Vasc Surg 46:928-933<br />
21. Hoornweg Ll, Dinkelman Mk, Goslings Jc et al.<br />
(2006) Endovascular management of traumatic<br />
ruptures of the thoracic aorta: a retrospective<br />
multicenter analysis of 28 cases in The Netherlands. J<br />
Vasc Surg 43:1096-1102; discussion 1102 [LoE 4]<br />
22. Huh J, Wall Mj, Jr., Estrera Al et al. (2003) Surgical<br />
management of traumatic pulmonary injury. Am J<br />
Surg 186:620-624 [LoE 4]<br />
23. Jahromi As, Kazemi K, Safar Ha et al. (2001)<br />
Traumatic rupture of the thoracic aorta: cohort study<br />
and systematic review. J Vasc Surg 34:1029-1034<br />
[LoE 3b]<br />
24. Karmy-Jones R, Jurkovich Gj, Nathens Ab et al.<br />
(2001) Timing of urgent thoracotomy for hemorrhage<br />
after trauma: a multicenter study. Arch Surg 136:513-<br />
518 [LoE 3b]<br />
25. Karmy-Jones R, Nathens A, Jurkovich Gj et al. (2004)<br />
Urgent and emergent thoracotomy for penetrating<br />
chest trauma. J Trauma 56:664-668; discussion 668-<br />
669 [LoE 4]<br />
26. Kiser Ac, O'brien Sm, Detterbeck Fc (2001) Blunt<br />
tracheobronchial injuries: treatment and outcomes.<br />
Ann Thorac Surg 71:2059-2065 [LoE 4]<br />
27. Kummer C, Netto Fs, Rizoli S et al. (2007) A review<br />
of traumatic airway injuries: potential implications for<br />
airway assessment and management. Injury 38:27-33<br />
[LoE 2b]<br />
28. Maggisano R, Nathens A, Alexandrova Na et al.<br />
(1995) Traumatic rupture of the thoracic aorta: should<br />
one always operate immediately? Ann Vasc Surg<br />
9:44-52 [LoE 3b]<br />
29. Mansour Ma, Moore Ee, Moore Fa et al. (1992)<br />
Exigent postinjury thoracotomy analysis of blunt<br />
versus penetrating trauma. Surg Gynecol Obstet<br />
175:97-101 [LoE 3b]<br />
30. Martin Mj, Mcdonald Jm, Mullenix Ps et al. (2006)<br />
Operative management and outcomes of traumatic<br />
lung resection. J Am Coll Surg 203:336-344 [LoE 2b]<br />
31. Marty-Ane Ch, Berthet Jp, Branchereau P et al.<br />
(2003) Endovascular repair for acute traumatic rupture<br />
Emergency surgery phase - Thorax 307
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
of the thoracic aorta. Ann Thorac Surg 75:1803-1807<br />
[LoE 4]<br />
32. Mcnamara Jj, Messersmith Jk, Dunn Ra et al. (1970)<br />
Thoracic injuries in combat casualties in Vietnam.<br />
Ann Thorac Surg 10:389-401 [LoE 3b]<br />
33. Mcswain Ne, Jr. (1992) Blunt and penetrating chest<br />
injuries. World J Surg 16:924-929 [LoE 4]<br />
34. Meredith Jw, Hoth Jj (2007) Thoracic trauma: when<br />
and how to intervene. Surg Clin North Am 87:95-118,<br />
vii [LoE 2a]<br />
35. Miller Pr, Kortesis Bg, Mclaughlin Ca, 3rd et al.<br />
(2003) Complex blunt aortic injury or repair:<br />
beneficial effects of cardiopulmonary bypass use. Ann<br />
Surg 237:877-883; discussion 883-874 [LoE 2b]<br />
36. Ott Mc, Stewart Tc, Lawlor Dk et al. (2004)<br />
Management of blunt thoracic aortic injuries:<br />
endovascular stents versus open repair. J Trauma<br />
56:565-570 [LoE 4]<br />
37. Peterson Bg, Matsumura Js, Morasch Md et al. (2005)<br />
Percutaneous endovascular repair of blunt thoracic<br />
aortic transection. J Trauma 59:1062-1065 [LoE 1]<br />
38. Pettiford Bl, Luketich Jd, Landreneau Rj (2007) The<br />
management of flail chest. Thorac Surg Clin 17:25-33<br />
[LoE 4]<br />
39. Reed Ab, Thompson Jk, Crafton Cj et al. (2006)<br />
Timing of endovascular repair of blunt traumatic<br />
thoracic aortic transections. J Vasc Surg 43:684-688<br />
[LoE 4]<br />
40. Rossbach Mm, Johnson Sb, Gomez Ma et al. (1998)<br />
Management of major tracheobronchial injuries: a 28year<br />
experience. Ann Thorac Surg 65:182-186 [LoE<br />
4]<br />
41. Rousseau H, Dambrin C, Marcheix B et al. (2005)<br />
Acute traumatic aortic rupture: a comparison of<br />
surgical and stent-graft repair. J Thorac Cardiovasc<br />
Surg 129:1050-1055 [LoE 3b]<br />
42. Rousseau H, Soula P, Perreault P et al. (1999)<br />
Delayed treatment of traumatic rupture of the thoracic<br />
aorta with endoluminal covered stent. Circulation<br />
99:498-504 [LoE 4]<br />
43. Schneider T, Storz K, Dienemann H et al. (2007)<br />
Management of iatrogenic tracheobronchial injuries: a<br />
retrospective analysis of 29 cases. Ann Thorac Surg<br />
83:1960-1964 [LoE 2b]<br />
44. Schneider T, Volz K, Dienemann H et al. (2009)<br />
Incidence and treatment modalities of<br />
tracheobronchial injuries in Germany. Interact<br />
Cardiovasc Thorac Surg 8:571-576 [LoE 2b]<br />
45. Symbas Pn, Sherman Aj, Silver Jm et al. (2002)<br />
Traumatic rupture of the aorta: immediate or delayed<br />
repair? Ann Surg 235:796-802 [LoE 2b]<br />
46. Tanaka H, Yukioka T, Yamaguti Y et al. (2002)<br />
Surgical stabilization of internal pneumatic<br />
stabilization? A prospective randomized study of<br />
management of severe flail chest patients. J Trauma<br />
52:727-732; discussion 732 [LoE 4]<br />
47. Tang Gl, Tehrani Hy, Usman A et al. (2008) Reduced<br />
mortality, paraplegia, and stroke with stent graft repair<br />
of blunt aortic transections: a modern meta-analysis. J<br />
Vasc Surg 47:671-675 [LoE 2a]<br />
48. Vodicka J, Spidlen V, Safranek J et al. (2007) [Severe<br />
injury to the chest wall--experience with surgical<br />
therapy]. Zentralbl Chir 132:542-546 [LoE 4]<br />
49. Voggenreiter G, Neudeck F, Aufmkolk M et al.<br />
(1998) Operative chest wall stabilization in flail chest-<br />
-outcomes of patients with or without pulmonary<br />
contusion. J Am Coll Surg 187:130-138 [LoE 4]<br />
50. Wall Mj, Jr., Hirshberg A, Lemaire Sa et al. (2001)<br />
Thoracic aortic and thoracic vascular injuries. Surg<br />
Clin North Am 81:1375-1393 [LoE 4]<br />
51. Wall Mj, Jr., Soltero E (1997) Damage control for<br />
thoracic injuries. Surg Clin North Am 77:863-878<br />
[LoE 4]<br />
52. Xenos Es, Freeman M, Stevens S et al. (2003)<br />
Covered stents for injuries of subclavian and axillary<br />
arteries. J Vasc Surg 38:451-454[LoE 4]<br />
Emergency surgery phase - Thorax 308
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.3 Diaphragm<br />
Key recommendation:<br />
When detected during the primary diagnostic study and/or intraoperative<br />
diagnosis, a traumatic diaphragmatic rupture should be quickly closed.<br />
Explanation:<br />
GoR B<br />
A diaphragmatic rupture in up to 1.6% of cases due to blunt injuries is mainly caused by a lateral<br />
collision in road traffic accidents and predominantly affects the left diaphragm side [1–7].<br />
There are no valid data available on the ideal time for surgery in the multiply injured patient.<br />
Only a pragmatic recommendation can be made that the rupture should be quickly closed if there<br />
is intrathoracic displacement of abdominal organs. This also applies to the intraoperative<br />
identification of a diaphragmatic rupture in the case of a cavity opening due to other injuries.<br />
There is currently no clear evidence that a deferred closure increases the case fatality rate. With<br />
an all-cause mortality of 17%, the random effects meta-regression of 22 studies (n = 980) from<br />
1976-1992 [7] showed no correlation between the frequency of deferred management and the<br />
case fatality rate (beta -0.013, 95% CI: - 0.67– - 0.240). In a current analysis of 4,153 patients on<br />
the National Trauma Database, pleural empyema was also not associated with the timing of the<br />
surgical intervention [8].<br />
In the acute situation in patients with unstable circulation and if there are no thoracic lesions,<br />
surgical access is ideally via a transabdominal approach [9]. A thoraco-abdominal approach is<br />
used in confirmed combination injuries or if the suture is technically difficult to carry out. If<br />
management is delayed for 7-10 days, a thoracotomy is recommended due to intrathoracic<br />
adhesions [7, 10].<br />
The diaphragm defect can usually be closed using a direct suture; defect grafting is only rarely<br />
necessary [1, 6, 10]. On the basis of the available data, no conclusions can be drawn on the<br />
success rates of specific suturing techniques (continuous versus single knot) or suturing materials<br />
(monofilament versus braided, absorbable versus non-absorbable). There are numerous reports in<br />
the literature on endoscopic techniques for closing post-traumatic diaphragmatic hernias [11,<br />
12]; at present, however, no importance can be ascribed to these in the emergency surgery phase.<br />
Emergency surgery phase - Diaphragm 309
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Athanassiadi K, Kalavrouziotis G, Athanassiou M et<br />
al. Blunt diaphragmatic rupture. Eur J Cardiothorac<br />
Surg 1999;15(4):469-474 [LoE 4].<br />
2. Bergeron E, Clas D, Ratte S et al. Impact of deferred<br />
treatment of blunt diaphragmatic rupture: a 15-year<br />
experience in six trauma centers in Quebec. J Trauma<br />
2002;52(4):633-640 [LoE 4].<br />
3. Brasel KJ, Borgstrom DC, Meyer P, Weigelt JA.<br />
Predictors of outcome in blunt diaphragm rupture. J<br />
Trauma 1996;41(3):484-487 [LoE 4].<br />
4. Chughtai T, Ali S, Sharkey P, Lins M, Rizoli S.<br />
Update on managing diaphragmatic rupture in blunt<br />
trauma: a review of 208 consecutive cases. Can J Surg<br />
2009;52(3):177-181 [LoE 4].<br />
5. Kearney PA, Rouhana SW, Burney RE. Blunt rupture<br />
of the diaphragm: mechanism, diagnosis, and<br />
treatment. Ann Emerg Med 1989;18(12):1326-1330<br />
[LoE 4].<br />
6. Mihos P, Potaris K, Gakidis J et al. Traumatic rupture<br />
of the diaphragm: experience with 65 patients. Injury<br />
2003;34(3):169-172 [LoE 4].<br />
7. Shah R, Sabanathan S, Mearns AJ, Choudhury AK.<br />
Traumatic rupture of diaphragm. Ann Thorac Surg<br />
1995;60(5):1444-1449 [LoE 5].<br />
8. Barmparas G, Dubose J, Teixeira PG et al. Risk<br />
factors for empyema after diaphragmatic injury:<br />
results of a National Trauma Databank analysis. J<br />
Trauma 2009;66(6):1672-1676 [LoE 2b].<br />
9. Waldschmidt ML, Laws HL. Injuries of the<br />
diaphragm. J Trauma 1980;20(7):587-592 [LoE 4].<br />
10. Matsevych OY. Blunt diaphragmatic rupture: four<br />
year's experience. Hernia 2008;12(1):73-78 [LoE 5].<br />
11. Lomanto D, Poon PL, So JB et al.<br />
Thoracolaparoscopic repair of traumatic<br />
diaphragmatic rupture. Surg Endosc 2001;15(3):323.<br />
12. Ouazzani A, Guerin E, Capelluto E et al. A<br />
laparoscopic approach to left diaphragmatic rupture<br />
after blunt trauma. Acta Chir Belg 2009;109(2):228-<br />
231.<br />
13. Waldschmidt ML, Laws HL. Injuries of the<br />
diaphragm. J Trauma 1980;20(7):587-592<br />
Emergency surgery phase - Diaphragm 310
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.4 Abdomen<br />
Surgical approach path<br />
Key recommendation:<br />
In the trauma situation, preference should be given to the midline laparotomy<br />
over other approach paths.<br />
Explanation:<br />
GoR B<br />
The midline laparotomy represents an anatomically justified universal surgical approach path to<br />
the traumatized abdomen. It can be performed quickly causing little bleeding and permits a good<br />
overview of all 4 quadrants [9, 10].<br />
There is only one quasi-randomized study, which is over 25 years old (treatment group allocation<br />
according to even or odd admission number), in which the midline laparotomy was compared<br />
with a transverse upper abdominal laparotomy in patients with abdominal trauma [11]. The<br />
wound infection rates in patients with negative and positive laparotomy were 2% and 11%<br />
irrespective of the selected approach path. The mean period under anesthesia was 25 minutes<br />
shorter after positive midline laparotomy than after the transverse upper abdominal laparotomy<br />
(Table 14). This difference was statistically significant according to the published data (p<br />
= 0.02). However, there were no standard deviations reported nor was a further breakdown of<br />
surgery times undertaken. The study cannot serve as proof in favor of a specific type of incision<br />
but supports the possibility of surgical preferences (“Adequacy of organ exposure is still a matter<br />
of personal preference”).<br />
Indirect evidence comes from randomized studies of elective abdominal interventions. A<br />
Cochrane Review suggests an advantage of the transverse incision with regard to the<br />
postoperative requirement for morphine equivalents, lung function, and the rate of incisional<br />
hernias [12]. A difference in the rate of pulmonary complications or in wound infections could<br />
not be detected. The multicenter randomized POVATI (Postsurgical Pain Outcome of Vertical<br />
and Transverse Abdominal Incision) Study published in 2009 showed an equivalence in the<br />
primary endpoint of postoperative analgesia requirement and lack of differences in secondary<br />
endpoints such as pulmonary complications, mortality, and incisional hernias after 1 year [13].<br />
The authors also stress here the possibility of a situation-dependent approach to the abdomen<br />
(“The decision about the incision should be driven by surgeon preference with respect to the<br />
patient’s disease and anatomy”).<br />
Emergency surgery phase - Abdomen 311
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 14: Midline laparotomy versus transverse upper abdominal laparotomy in abdominal<br />
trauma<br />
Study LoE Patients Results<br />
Stone et al. 1983<br />
[11]<br />
2b 339 patients with<br />
blunt or penetrating<br />
abdominal trauma<br />
Midline laparotomy (n =<br />
177)<br />
Mean period under<br />
anesthesia: positive<br />
laparotomy (n = 66)<br />
215 min, negative<br />
laparotomy (n = 111)<br />
126 min<br />
Transverse upper<br />
abdominal laparotomy (n<br />
= 162)<br />
Mean period under<br />
anesthesia: positive<br />
laparotomy (n = 61)<br />
240 min, negative<br />
laparotomy (n = 101) 132<br />
min<br />
Indications for a diagnostic laparoscopy are dealt with in the subsection “Emergency room:<br />
diagnostic study of the abdomen”. The recommendations updated in 2007 of the Society of<br />
American Gastrointestinal and Endoscopic Surgeons (SAGES) also apply [14]. Reference is<br />
made to the evidence-based guideline of the European Association for Endoscopic Surgery<br />
(EAES) for therapeutic laparoscopy in abdominal trauma [15]. Numerous authors report on<br />
laparoscopic and hand-assisted laparoscopic abdominal surgery interventions performed on blunt<br />
and penetrating abdominal trauma (e.g., hemostasis, oversewing, and resection of hollow organs)<br />
[16–20]. There are no clinical studies in which laparoscopy was compared with a laparotomy or<br />
used in the particular case of polytrauma. The consensus of the EAES should be followed,<br />
namely that the currently available data prohibits a clear recommendation in favor of therapeutic<br />
laparoscopic interventions for abdominal trauma (“Nevertheless, the scarceness of clinical data<br />
prohibits a clear recommendation in favor of therapeutic laparoscopy for trauma”).<br />
Damage control: General principles<br />
Key recommendation:<br />
In patients with unstable circulation and complex intraabdominal damage,<br />
priority should be given to the damage control principle (hemostasis,<br />
packing/wrapping, temporary abdominal wall closure) over attempted<br />
definitive treatment.<br />
Explanation:<br />
GoR B<br />
The term “damage control” (DC) was coined by the US navy and originally referred to the<br />
capacity of a ship to absorb damage yet maintain mission integrity [21]. The basis and indication<br />
for DC or an abbreviated/truncated laparotomy is the AHC triad consisting of acidosis (pH<br />
< 7.2), hypothermia (< 34 °C), and coagulopathy (International Normalized Ratio [INR] > 1.6 or<br />
transfusion requirement during surgery > 4 l) [22]. There is currently no standardized or uniform<br />
DC algorithm. Major accepted elements are 1) rapid hemostasis in injuries to the<br />
parenchymatous upper abdominal organs and avoiding peritoneal contamination through the<br />
Emergency surgery phase - Abdomen 312
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
simple repair of hollow organ injuries, if necessary also discontinuance of resection, 2)<br />
temporary closure of the abdomen, 3) intensive medical stabilization of body temperature,<br />
hemodynamics, and coagulation, 4) planned re-surgery to repair and reconstruct organ injuries,<br />
and 5) definitive abdominal wall closure [22–25].<br />
An important element in bleeding from the liver is the perihepatic packing. The liver should be<br />
completely mobilized from its suspensory ligaments and the packing inserted around the<br />
posterior paracaval surface and subhepatic between liver and hepatic flexure in order to achieve<br />
compression against the diaphragm without hindering the venous outflow from the hepatic veins<br />
[26–30].<br />
Despite the existence of an AHC triad, a survival advantage for patients after DC compared to<br />
one-step, definitive surgical treatment (definitive laparotomy, DL) was confirmed in 3 small<br />
retrospective cohort studies [31–33]. On the other hand, another retrospective cohort study<br />
showed a survival advantage in the DL group [34] (Table 15). The pooled relative risk (random<br />
effects) is 0.79 (95% CI: 0.48–1.33) in favor of DC. If only the maximum injured in the study by<br />
Rotondo are considered [32], the pooled relative risk is 0.60 (95% CI: 0.30–1.19). There was no<br />
multivariate adjustment in any of these studies for differences in injury severity or other<br />
confounders; the results are thus subject to bias.<br />
In a current Cochrane Review, the authors could not identify any randomized studies despite a<br />
comprehensive search strategy in 9 databases (including congress abstracts and “gray” literature)<br />
and a hand search [35].<br />
Individual reports suggest survival rates of 90% after DC even in a prognostically unfavorable<br />
baseline situation [36]. In the majority of larger case series, on the other hand, the case fatality<br />
rate of the injured who required a DC laparotomy is 25-50% [37–39].<br />
Emergency surgery phase - Abdomen 313
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 15: Damage Control versus definitive management<br />
Study LoE Patients Result<br />
Stone et al.<br />
1983 [31]<br />
Rotondo et al.<br />
1993 [32]<br />
MacKenzie et<br />
al. 2007 [33]<br />
Nicholas et al.<br />
2003 [34]<br />
2b 31 patients with<br />
penetrating or blunt<br />
abdominal injuries<br />
and intra-operative<br />
development of a<br />
coagulopathy<br />
2b 46 patients with<br />
penetrating<br />
abdominal injuries<br />
2b 37 patients with<br />
penetrating or blunt<br />
hepatic injuries,<br />
grade 4/5<br />
2b 250 patients with<br />
penetrating<br />
abdominal injuries<br />
Definitive management<br />
(n = 14)<br />
Overall survival rate:<br />
1/14 (7%)<br />
Damage control<br />
(n = 17) a<br />
Overall survival rate:<br />
11/17 (65%)<br />
RR 0.11 (95% confidence interval: 0.02–0.75)<br />
Definitive management<br />
(n = 22)<br />
Overall survival rate:<br />
12/22 (55%)<br />
Damage Control (n = 24) b<br />
Overall survival rate:<br />
14/24 (58%)<br />
RR 0.94 (95% confidence interval: 0.56–1.56)<br />
Survival rate for max.<br />
injury: 1/9 (11%) c<br />
Survival rate for max.<br />
injury: 10/13 (77%) c<br />
RR 0.14 (95% confidence interval: 0.02–0.94)<br />
Definitive management<br />
(n = 30)<br />
Overall survival rate:<br />
19/30 (63%)<br />
Damage control<br />
(n = 7)¶<br />
Overall survival rate:<br />
7 /7 (100%)<br />
RR 0.63 (95% confidence interval: 0.48–0.83)<br />
Definitive management<br />
(n = 205)<br />
Overall survival rate:<br />
184/205 (90%)<br />
Damage control<br />
(n = 45)<br />
Overall survival rate:<br />
33/45 (73%)<br />
RR 1.22 (95% confidence interval: 1.02–1.47, p =<br />
0.0032)<br />
a: Immediate arrest, packing, abdominal closure under tension, mean time until second look: 27 h<br />
b: four-quadrant packing, hemostasis, ligature or simple (clamp) suture for hollow organ injuries,<br />
temporary abdominal wall closure, mean time until second look: 32h<br />
c: Injury to great vessels + ≥ 2 visceral injuries; packing + angioembolization<br />
The Pringle maneuver with clamping of the portal vein and common hepatic artery is possibly<br />
one of the oldest DC techniques for the temporary hemostasis of severe hepatic injuries [40].<br />
Although an ischemia time of 45-60 minutes through the hepatic parenchyma is tolerated in<br />
patients with no preoperative shock event without serious postoperative function deficit, the full<br />
utilization of this ischemia period would seem to increase noticeably the risk of postoperative<br />
liver failure in the multiply injured patient [41]. In a Chinese case series, 5 out of 7 patients who<br />
had undergone a Pringle maneuver died because of a retrohepatic caval tear [42].<br />
Emergency surgery phase - Abdomen 314
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Damage control: Temporary abdominal wall closure<br />
Key recommendations:<br />
After DC laparotomy, the abdomen should be closed only temporarily and not<br />
using a fascial suture.<br />
The temporary abdominal wall closure in DC laparotomy should be<br />
performed using synthetic material which enables a stepwise convergence of<br />
the fascial edges.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
Primary fascial closure after DC laparotomy increases the risk of abdominal compartment<br />
syndrome (ACS). After primary fascial suture, a 6-fold increased risk for ACS was reported<br />
compared to only skin closure and insertion of a 3-liter irrigation bag for cystoscopies (Bogotá<br />
bag) [43]. Against the reduced risk for ACS by using a temporary closure, there is fluid loss and<br />
disturbed temperature regulation due to the large exchange surface and the difficulty of<br />
reconstructing the abdominal wall. Bogotá bag equivalents or commercial products with zip or<br />
hook-and-loop closure (Wittmann patch or Artificial Burr) have established themselves as<br />
temporary materials [44]. In addition, there is widespread use of vacuum sealing. The results of<br />
case series were summarized in a current systematic review paper [45]. According to this, the<br />
Wittmann patch is associated with the highest success rate for an abdominal wall closure. A<br />
retrospective cohort study comes to similar results [46]. In a small randomized study, no<br />
difference between a temporary closure using a vacuum dressing and polyglactin-910 mesh<br />
could be detected [47].<br />
Emergency surgery phase - Abdomen 315
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 16: Methods for abdominal wall closure<br />
Study LoE Patients Method Result<br />
van<br />
Hensbroek<br />
et al. 2009<br />
[45]<br />
Weinberg<br />
et al. 2008<br />
[46]<br />
Bee et al.<br />
2008 [47]<br />
4 Systematic<br />
review of case<br />
series<br />
2b 59 patients<br />
with blunt or<br />
penetrating<br />
abdominal<br />
trauma<br />
1b 59 patients<br />
with blunt or<br />
penetrating<br />
abdominal<br />
trauma<br />
a: using foil, abdominal sheets and Redon drains<br />
Wittmann patch<br />
KCI-VACTM<br />
Vacuum dressing a<br />
Skin closure<br />
Zip closure<br />
Silo (Bogotá bag)<br />
Net or sheet<br />
“Pre-Wittmann<br />
patch” (n = 23)<br />
“Wittmann patch”<br />
(n = 36)<br />
Polyglactin-910<br />
mesh<br />
(n = 20)<br />
Vacuum dressing<br />
(n = 26) a<br />
KCI-VACTM<br />
(n = 5)<br />
Survival rate:<br />
146/180 (81%)<br />
Survival rate:<br />
19/251 (78%)<br />
Survival rate:<br />
846/1,186<br />
(71%)<br />
Survival rate:<br />
62/101 (61%)<br />
Survival rate:<br />
89/135 (66%)<br />
Survival rate:<br />
61/109 (56%)<br />
Survival rate:<br />
844/1,176<br />
(72%)<br />
Case fatality<br />
rate:<br />
5/20 (25%)<br />
Abscess:<br />
9/15 (60%)<br />
Case fatality<br />
rate:<br />
8/31 (26%)<br />
Abscess: 12/23<br />
(52%)<br />
Abdominal wall<br />
closure:<br />
127/146 (88%)<br />
Abdominal wall closure<br />
118/195 (60%)<br />
Abdominal wall closure<br />
444/846 (53%)<br />
Abdominal wall closure<br />
27/62 (43%)<br />
Abdominal wall closure<br />
32/89 (36%)<br />
Abdominal wall closure<br />
21/61 (34%)<br />
Abdominal wall closure<br />
214/844 (25%)<br />
Fascial closure:<br />
7/23 (30%)<br />
Fascial closure:<br />
28/36 (78%)<br />
Fascial closure:<br />
4/15 (27%)<br />
Fascial closure:<br />
7/23 (30%)<br />
Emergency surgery phase - Abdomen 316
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Damage control: Second look after packing<br />
Key recommendation:<br />
After packing intraabdominal bleeding, a second look should be undertaken<br />
and the tamponade replaced between 24 and 48 hours after the first<br />
intervention.<br />
Explanation:<br />
GoR B<br />
After packing and intensive medical stabilization as part of the damage control sequence, a relaparotomy<br />
is necessary to replace the abdominal sheets and also for definitive injury<br />
management, if applicable. A balance must be maintained here between the risk of fresh<br />
bleeding and the possible complications (infections, fistula, restricted pulmonary function,<br />
abdominal compartment syndrome) from the foreign material.<br />
The available data from retrospective cohort studies show that unpacking after 24-36 hours is<br />
associated with an increased risk of bleeding (pooled relative risk, fixed effects: 3.51, 95%<br />
confidence interval: 1.39–8.90) [48, 49]. There is no clear evidence that leaving the abdominal<br />
sheets for a period of 48 hours increases the risk of septic complications (pooled relative risk,<br />
fixed effects: 1.01; 95% CI: 0.59–1.70) [48–51]. In the study by Abikhaled, however, leaving the<br />
tamponades > 72 hours was associated with an almost 7-fold increase in the relative risk for<br />
intraabdominal abscesses (6.77; 95% CI: 0.84–54.25) [50]. From a pragmatic viewpoint,<br />
therefore, the re-laparotomy should be planned for not sooner than 24 hours and not later than 48<br />
hours after the first intervention.<br />
Emergency surgery phase - Abdomen 317
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 17: Second look after packing<br />
Study LoE Patients Result<br />
Nicol et al.<br />
2007 [48]<br />
Cué et al.<br />
1990 [51]<br />
Caruso et al.<br />
1999 [49]<br />
Sharp et al.<br />
1992 [52]<br />
Abikhaled et<br />
al. 1997 [50]<br />
2b 93 patients with<br />
penetrating or<br />
blunt hepatic<br />
trauma<br />
2b 21 patients with<br />
penetrating or<br />
blunt hepatic<br />
trauma<br />
2b 93 patients with<br />
penetrating or<br />
blunt hepatic<br />
trauma<br />
2b 22 patients with<br />
penetrating or<br />
blunt hepatic<br />
trauma<br />
2b 35 patients with<br />
penetrating or<br />
blunt abdominal<br />
trauma<br />
Definitive abdominal wall closure<br />
Key recommendation:<br />
Second look<br />
24h:<br />
(n = 25):<br />
Subsequent<br />
bleeding:<br />
8/25 (32%)<br />
Packing in situ 24<br />
h (n = 8):<br />
Complications:<br />
5/8 (63%)<br />
Packing in situ 24<br />
h (n = 7):<br />
Abscess:<br />
2/7 (29%)<br />
Second look<br />
48h:<br />
(n = 44):<br />
Subsequent<br />
bleeding 5/44<br />
(11%)<br />
Packing in situ 48<br />
h (n = 44):<br />
Complications:<br />
6/44 (14%)<br />
Packing in situ 48<br />
h (n = 6):<br />
Abscess:<br />
2/6 (33%)<br />
Second look < 36 h (n = 39):<br />
Subsequent bleeding: 8/39<br />
(21%)<br />
Complications:<br />
13/39 (33%)<br />
Case fatality rate: 7/39 (18%)<br />
6 patients with septic<br />
complications:<br />
Packing in situ 2.2 ± 0.4 (2–<br />
3) days<br />
Packing in ≤ 72 h (n = 22):<br />
Abscess 1/22 (5%)<br />
Sepsis 11/22 (50%)<br />
Case fatality rate 1/22 (5%)<br />
Second look 72 h<br />
(n = 3):<br />
Subsequent<br />
bleeding:<br />
0/3<br />
Packing in situ 72<br />
h (n = 20):<br />
Complications:<br />
3/20 (15%)<br />
Packing in situ 72<br />
h (n = 8):<br />
Abscess:<br />
3/8 (38%)<br />
Second look 36-72 h<br />
(n = 24):<br />
Subsequent bleeding: 1/24<br />
(4%)<br />
Complications:<br />
7/29 (29%)<br />
Case fatality rate: 7/24 (29%)<br />
6 patients without septic<br />
complications:<br />
Packing in situ 2.0 ± 1.0 (1–<br />
7) days<br />
Packing in situ > 72 h<br />
(n = 13):<br />
Abscess 4/13 (31%)<br />
Sepsis 10/13 (77%)<br />
Case fatality rate 6/13 (46%)<br />
Definitive fascial closure should be continuous using slow absorbable or nonabsorbable<br />
suture material.<br />
Explanation:<br />
GoR B<br />
The technique of fascial closure after a laparotomy is well-known to be controversial and is often<br />
determined by the surgeon’s preference. The best available evidence on decision-making is<br />
obtained from randomized studies of elective abdominal interventions. It appears pragmatic and<br />
expedient to transfer any clear trends in favor of a specific method to the trauma scenario.<br />
Emergency surgery phase - Abdomen 318
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
There are 2 meta-analyses of randomized studies for which the data pool only partially overlaps.<br />
Both show a significant reduction in risk for incisional hernias through non-absorbable suture<br />
material and continuous sutures [53, 54]. The results of the multicenter INSECT (Interrupted or<br />
Continuous Slowly Absorbable Sutures – Evaluation of Abdominal Closure Techniques) trial<br />
published in 2009 show a similar though not significantly statistical trend [55].<br />
The updated common Peto odds ratio from all available randomized studies on the comparison<br />
of continuous slowly absorbable and rapidly absorbable single knot sutures is 0.79 for incisional<br />
hernias (95% CI: 0.61–1.01) and for wound infections 1.49 (95% CI: 1.15–1.94).<br />
Angioembolization<br />
Key recommendations:<br />
If, in the case of a patient with hepatic injury who can be hemodynamically<br />
stabilized, there is evidence of arterial bleeding in a contrast agent CT,<br />
selective angioembolization or a laparotomy should be performed.<br />
In the case of splenic injuries grade 1-3 which require intervention, selective<br />
angioembolization can be performed instead of surgical hemostasis.<br />
In the case of retroperitoneal bleeding which requires intervention, selective<br />
angioembolization can be performed instead of or in addition to surgical<br />
hemostasis.<br />
Explanation:<br />
GoR B<br />
GoR 0<br />
GoR 0<br />
Interventional radiology has an established value in polytrauma management and is used both in<br />
primary non-surgical treatment of organ injuries and as a neo-adjuvant and adjuvant intervention<br />
[56, 57]. If there is evidence of active bleeding from the contrast agent enhanced CT scan which<br />
cannot or must not be addressed operatively and if there is a good response to fluid and blood<br />
replacement in the emergency room, angioembolization can contribute towards sustained<br />
stabilization of the circulation [58, 59].<br />
There are no randomized studies. The currently best available evidence is on blunt and<br />
penetrating hepatic injuries and suggests a reduction in case fatality rate through additional<br />
angioembolization during DC management compared to operative treatment only (common RR<br />
[fixed effects] 0.47, 95% CI: 0.28–0.78) [60–65]. The bias due to lack of multivariate adjustment<br />
must be taken into consideration. Currently, there is no answer to the question as to whether<br />
angioembolization in hepatic injuries should be performed before or after the DC laparotomy.<br />
Two studies support early neoadjuvant angioembolization based on the lower complication rates<br />
[63, 65]. In 2 other studies, on the other hand, mortality was lowered if angioembolization was<br />
performed after a DC laparotomy [64, 66].<br />
Emergency surgery phase - Abdomen 319
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Decision-making must be on an individual case basis on the availability and presence of an<br />
experienced interventional radiologist, the success of circulation-stabilizing measures in the<br />
emergency room, the intraoperative finding, and the postoperative hemodynamics.<br />
The same applies to angioembolization in the case of bleeding from the spleen, where more upto-date<br />
data now seems to call for caution [67–70]. Compared to nonoperative treatment,<br />
angioembolization did not lead to a reduction in either the treatment failure rate (common RR<br />
[random effects] 1.13; 95% CI: 0.86-1.48) or mortality (common RR [fixed effects] 1.19; 95%<br />
CI: 0.66–1.15).<br />
Emergency surgery phase - Abdomen 320
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 18: Angioembolization<br />
Study LoE Patients Result<br />
Asensio et<br />
al.<br />
2007 [61]<br />
Johnson et<br />
al.<br />
2002 [62]<br />
Asensio et<br />
al.<br />
2003 [60]<br />
Wahl et al.<br />
2002 [65]<br />
2b 75 patients with<br />
penetrating or blunt<br />
hepatic trauma grade 4/5<br />
Angioembolization directly after DC laparotomy (n = 17) DC laparotomy without angioembolization (n = 58)<br />
Case fatality rate 2/17 (12%) Case fatality rate 21/58 (36%)<br />
2b 19 patients with<br />
penetrating or blunt<br />
Angioembolization directly after DC laparotomy (n = 8) DC laparotomy without angioembolization (n = 11)<br />
hepatic trauma grade 1–5 Case fatality rate 1/8 (13%) Case fatality rate 4/11 (36%)<br />
2b 103 patients with<br />
penetrating or blunt<br />
hepatic trauma grade 4/5<br />
2b 126 patients with blunt<br />
hepatic trauma grade 1–6<br />
Angioembolization directly after DC laparotomy (n = 23) DC laparotomy without angioembolization (n = 80)<br />
Case fatality rate 7/23 (30%)<br />
(grade 4: 4/14 [28%], grade 5: 3/9 [33%])<br />
RR 0.51 (95% confidence interval 0.27-0.98)<br />
Case fatality rate 52/80 (65%)<br />
(grade 4: 15/37 [39%], grade 5: 37/43 [86%])<br />
OR (multivariate adjusted for RTS, direct surgical access to hepatic veins and packing):<br />
0.20 (95% confidence interval 0.05-0.72)<br />
Early AE<br />
before/instead of<br />
DC laparotomy<br />
(n = 6)<br />
Case fatality rate<br />
0/6 (0%),<br />
complications<br />
3/6 (50%)<br />
Late AE after DC<br />
laparotomy (n = 6)<br />
Case fatality rate 3/6<br />
(50%), complications<br />
6/6 (100%)<br />
DC laparotomy (n = 20) Nonoperative treatment (n = 94)<br />
Case fatality rate 7/20 (35%),<br />
complications 9/20 (45%)<br />
Case fatality rate 2/94 (2%),<br />
complications 2/94 (2%)<br />
(continued)<br />
Emergency surgery phase - Abdomen 321
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 18: Angioembolization - (continued)<br />
Study LoE Patients Result<br />
Mohr et al.<br />
2003 [63]<br />
Monnin et<br />
al.<br />
2008 [64]<br />
2b 26 patients with<br />
penetrating or blunt<br />
Early AE before/instead of DC laparotomy (n = 11) Late AE after DC laparotomy (n = 15)<br />
hepatic trauma grade 3–5 Case fatality rate 2/11 (18%), complications 5/11 (45%) Case fatality rate 5/15 (33%), complications 6/15 (40%)<br />
2b<br />
Table 19: Angiography<br />
14 patients with blunt<br />
hepatic trauma grade 3–5<br />
Study LoE Patients Result<br />
Velmahos<br />
et al. 2000<br />
[66]<br />
2b 137 patients with blunt or<br />
penetrating abdominal<br />
trauma<br />
(36 hepatic injuries)<br />
Early AE before/instead of DC laparotomy (n = 10) Late AE after DC laparotomy (n = 4)<br />
Case fatality rate 1/10 (10%) Case fatality rate 0/4 (0%)<br />
Emergency room<br />
angiography<br />
(n = 49)<br />
Case fatality rate:<br />
14/49 (29%)<br />
Emergency room ICU<br />
angiography<br />
(n = 15)<br />
Case fatality rate:<br />
3/15 (20%)<br />
Operating room<br />
angiography<br />
(n = 32)<br />
Case fatality rate:<br />
7/32 (22%)<br />
Operating room ICU<br />
angiography (n = 21)<br />
Case fatality rate:<br />
2/21 (10%)<br />
Emergency surgery phase - Abdomen 322
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 20: Interventions after blunt splenic injuries<br />
Study LoE Patients Result<br />
Cooney et<br />
al.<br />
2005 [69]<br />
Harbrecht<br />
et al.<br />
2007 [67]<br />
Smith et<br />
al.<br />
2006 [68]<br />
Duchesne<br />
et al.<br />
2008 [70]<br />
Wei et al.<br />
2008 [71]<br />
2b 194 patients with blunt<br />
splenic injuries grade<br />
1–5<br />
2b 349 patients with blunt<br />
splenic injuries grade<br />
1–5<br />
2b 221 patients with blunt<br />
splenic injuries grade<br />
1–5<br />
2b 154 patients with blunt<br />
splenic injuries grade<br />
1–5<br />
2b 87 patients with blunt<br />
splenic injuries grade<br />
1–5<br />
Angioembolization<br />
(n = 9)<br />
Success rate: 6/9 (67%)<br />
Case fatality rate: 0/9 (0%)<br />
Angioembolization<br />
(n = 46)<br />
Case fatality rate: 2/46 (4%)<br />
Success rates:<br />
grade 2: 16/17 (94%), grade 3: 76%,<br />
a, b<br />
grade 4: 88%<br />
Angioembolization<br />
(n = 41)<br />
Success rate:<br />
30/41 (73%)<br />
Nonoperative treatment<br />
(n = 137)<br />
Success rate: 126/137 (92%)<br />
Case fatality rate: 9/137 (7%)<br />
Nonoperative treatment<br />
(n = 303)<br />
Case fatality rate: 12/303 (4%)<br />
Success rates:<br />
grade 2: 225/236 (95%), grade 3: 86%,<br />
grade 4: 63% a<br />
Nonoperative treatment<br />
(n = 303)<br />
Success rate:<br />
114/124 (92%)<br />
Splenectomy<br />
(n = 48)<br />
Success rate: 48/48 (100%)<br />
Case fatality rate: 9/48 (19%)<br />
Splenectomy<br />
(n = 221)<br />
Case fatality rate 42/221 (19%)<br />
Splenectomy<br />
(n = 56)<br />
Success rate:<br />
56/56 (100%)<br />
Before carrying out angioembolization (n = 78) After carrying out angioembolization (n = 76)<br />
Case fatality rate: 14/78 (18%)<br />
Sepsis: 4/78 (5%)<br />
ARDS: 4/78 (5%)<br />
Angioembolization<br />
(n = 55)<br />
Case fatality rate: 4/55 (7%)<br />
abdominal complications: 2/55 (5%)<br />
Case fatality rate: 11/76 (14%)<br />
Sepsis: 9/76 (9%)<br />
ARDS: 17/76 (22%)<br />
Splenectomy<br />
(n = 37)<br />
Case fatality rate: 2/37 (5%)<br />
abdominal complications: 13/37 (35%)<br />
a: No. of patients unclear b: No effect of angioembolization on success rates after multivariate adjustment for age, AIS and abdominal concomitant injuries<br />
Emergency surgery phase - Abdomen 323
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Spleen-salvaging operations<br />
Key recommendations:<br />
The goal can be spleen-salvaging surgery in the case of splenic injuries of<br />
severity grade 1-3 according to AAST/Moore that require surgery.<br />
Preference should be given to splenectomy over a salvage attempt in patients<br />
with splenic injuries of severity grade 4-5 according to AAST/Moore that<br />
require surgery.<br />
Explanation:<br />
GoR 0<br />
GoR B<br />
The risk of an “overwhelming postsplenectomy syndrome (OPSI)” after a splenectomy is estimated<br />
at 2.5% [72]. In patients with stable circulation, splenic injuries only rarely represent an indication<br />
for laparotomy. Thus, only when surgery becomes necessary (e.g., in the case of unstable<br />
circulation or high transfusion requirement) does the question arise for the surgeon as to the<br />
possibility and the certainty of salvaging an organ. Complete mobilization of the spleen after<br />
separating the lienorenal and phrenicolienal ligaments is definitive for operative success [73].<br />
Unsurprisingly, due to different patient populations and injury severity scores, it is difficult to<br />
conduct a direct comparison between the results after splenectomy and salvage procedures. With<br />
stable splenorrhaphy frequency between 1988 and 1993, an analysis of the North Carolina Trauma<br />
Registry showed a trend in favor of primary nonoperative management and a rejection of the<br />
splenectomy. The comparison between the methods yielded, not surprisingly, a lower mortality<br />
after splenorrhaphy compared to splenectomy (RR 0.36, 95% CI: 0.18-0.73) at higher mean ISS in<br />
the splenectomy group (25 ± 12 versus 19 ± 11, p < 0001) [74]. In this cohort there were also 10<br />
patients with a mean ISS of 33 ± 15 where the salvage attempt failed. After the splenectomy, 2<br />
patients died. In another study with comparable injury severity, considerably fewer infections<br />
occurred after splenorrhaphy (RR 0.30, 95% CI: 0.13–0.70) [75]. A non-significant trend to overall<br />
higher complication rates after splenorrhaphy (RR 1.81; 95% CI: 0.36-9.02) despite lower injury<br />
severity was observed in another study [76].<br />
In a series of 326 patients from the early 1980s, the rates of spleen-salvaging operations for Moore<br />
I/II, III and IV/V injuries were 88.5%, 61.5%, and 7.7% [77]. A similar trend in relation to the ISS<br />
was also demonstrated in a more recent study with inclusion of 2,258 adult patients [78]. The failure<br />
quota (subsequent bleeding, secondary splenectomy) after a spleen salvage attempt was 7 out of 240<br />
(2.9%; 95% CI: 1.2–5.9%). A splenectomy was necessary in 66.4% of all patients with an ISS ≥ 15.<br />
In a multivariate analysis of 546 patients from a 17-year period, Carlin derived injuries of grade 4<br />
and 5 as independent predictive variables for a splenectomy [79]. However, whether this depicts the<br />
actual necessity of removing a spleen or merely the surgeon’s strong feelings cannot be<br />
conclusively evaluated. In the special case of 25 multiply injured patients with a mean ISS of 32.0<br />
(95% CI: 28.2-35.8), Aidonopoulos and colleagues observed subsequent bleeding requiring a<br />
Emergency surgery phase - Abdomen 324
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
splenectomy in 2 patients with injury grade 3 after suturing with a ‘figure of eight’ (0-0 chromic cat<br />
gut) [80].<br />
Emergency surgery phase - Abdomen 325
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 21: Interventions after blunt or penetrating splenic injuries<br />
Study LoE Patients Result<br />
Clancy et al.<br />
1997 [81]<br />
Gauer et al.<br />
2008 [82]<br />
Kaseje et al.<br />
2008 [83]<br />
a: Subsequent bleeding:<br />
b: Pancreas leaks and fistulas<br />
2b 1,255 patients with blunt<br />
or penetrating splenic<br />
injuries grade<br />
1–5<br />
2b 91 patients with blunt<br />
splenic injuries<br />
requiring surgery<br />
2b 91 patients with blunt<br />
and penetrating splenic<br />
injuries requiring<br />
surgery<br />
Splenorrhaphy<br />
(n = 150)<br />
Shock: 26/150 (17%)<br />
mean ISS: 19 ± 11<br />
Splenectomy after splenorrhaphy<br />
(n = 10)<br />
Shock: 2/10 (20%)<br />
mean ISS: 33 ± 15<br />
Splenectomy<br />
(n = 596)<br />
Shock: 149/596 (25%)<br />
mean ISS: 25 ± 12<br />
Case fatality rate: 8/150 (5%) Case fatality rate: 2/10 (20%) Case fatality rate: 88/596 (15%)<br />
Splenorrhaphy<br />
(n = 34)<br />
Splenectomy<br />
(n = 57)<br />
Mean ISS: 31 Mean ISS: 33<br />
Infections (total): 5/34 (15%)<br />
Pneumonias: 3/34 (9%)<br />
Splenorrhaphy<br />
(n = 16)<br />
Infections (total): 28/57 (49%)<br />
Pneumonias: 19/57 (33%)<br />
Splenectomy<br />
(n = 58)<br />
Mean ISS: 21 Mean ISS: 28<br />
Complications: 2/16 (13%) a Complications: 4/58 (7%) b<br />
Emergency surgery phase - Abdomen 326
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Hollow organ injuries<br />
Key recommendation:<br />
In the case of penetrating colon injuries, if technically possible, preference<br />
must be given over a two-step procedure with temporary stoma to oversewing<br />
only or to primary anastomosis in order to reduce the risk of intraabdominal<br />
infections.<br />
Explanation:<br />
GoR A<br />
Due to the contamination of the sterile abdominal cavity with mixed anaerobic flora, penetrating<br />
colon injuries represent a potentially life-threatening clinical picture. Thus, patients with<br />
abdominal gunshot wounds who must undergo immediate surgical treatment have a 100-fold<br />
higher relative risk of dying compared to patients with injuries that can be treated non-surgically<br />
or during secondary surgery [84].<br />
Since 1979, 6 randomized trials (RCTs) have been published in which the results after primary<br />
operative management to maintain continuity were compared with those after temporary<br />
insertion of an ileostomy [85–90]. These studies were summarized in a Cochrane Review<br />
updated in 2009 [91]. The observed trends were also reproduced in the multicenter study of the<br />
American Association for the Surgery of Trauma (AAST) [92].<br />
Based on the best available evidence, there is a non-significant trend in mortality in favor of<br />
primary anastomosis (RR 0.67; 95% CI: 0.31-1.45) with a marked reduction in complication<br />
rates (RR 0.73; 95% CI: 0.52-1.02). The risk of intraabdominal infections could possibly be<br />
reduced by 23% through primary anastomosis (RR 0.77; 95% CI: 0.55-1.06) even though clear<br />
scientific proof from an appropriately designed randomized study is unavailable. Current data<br />
from the US Iraq operations support the trends in favor of primary anastomosis [93]. It is unclear<br />
whether the available data can be transferred to blunt injuries. In this situation, however, biologic<br />
and clinical considerations argue more in favor of maintaining continuity.<br />
Stapling instruments represent a major valuable addition to the equipment for elective<br />
gastrointestinal interventions. Deep colorectal anastomoses were first made possible through the<br />
availability of circular staplers; laparoscopic intestinal surgery also gained from the option of<br />
stapled anastomoses.<br />
In a meta-analysis of 9 randomized studies (1,233 patients), however, there was no evidence of<br />
advantage from staplers compared to a hand suture in the endpoints mortality, anastomosis<br />
failure, wound infection, re-operation, and l<strong>eng</strong>th of stay in hospital [94]. On the other hand,<br />
there was a significantly increased risk of strictures after stapled anastomosis (Peto OR 3.59;<br />
95% CI: 2.02–6.35). The multicenter studies of the Western Trauma Association and AAST<br />
have produced evidence of a possible disadvantage from stapled colon anastomoses in the<br />
trauma situation [95, 96]. The weighted relative risk for all complications after hand suture<br />
compared to stapled anastomosis from both studies is 0.72 (95% CI: 0.45-1.15). For anastomosis<br />
Emergency surgery phase - Abdomen 327
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
failures and intraabdominal abscesses, the common RR can be estimated at 0.90 (95% CI: 0.36-<br />
2.28) and 0.74 (95% CI: 0.42-1.28).<br />
Two multicenter studies yielded similar, again non-significant trends for small intestine<br />
anastomoses [95, 97]. The hand suture is possibly associated with a reduction in all<br />
complications (RR 0.75; 95% CI: 0.31-1.82). Anastomosis failures and intraabdominal abscesses<br />
were also observed less frequently after hand suturing (RR 0.43; 95% CI: 0.08–2.42 and RR<br />
0.54; 95% CI: 0.18–1.64).<br />
The results of a randomized trial conducted under elective conditions suggest that a single-layer,<br />
continuous hand suture can be carried out without risk. In this study [98], no difference could be<br />
detected in the failure rates between a single-layer (2/65) and a two-layer/Lembert suture (1/67).<br />
The observed frequency of abscesses was also identical between the two treatment arms (2/65<br />
and 2/67). Nineteen and 12 trauma patients were also included in the study.<br />
Emergency surgery phase - Abdomen 328
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 22: Primary anastomosis versus ileostomy after penetrating colon injury<br />
Study LoE Patients Result<br />
Nelson et al.<br />
2009 [91]<br />
Demetriades<br />
et al. 2001<br />
[92]<br />
Vertrees et<br />
al. 2009 [93]<br />
1a Meta-analysis of 6<br />
RCTs (n = 707)<br />
2b 297 patients with<br />
penetrating colon<br />
injuries<br />
2b 65 wounded (Enduring<br />
Freedom/ Iraqi<br />
Freedom) with<br />
penetrating colon<br />
injuries<br />
Primary anastomosis<br />
(n = 361)<br />
Ileostomy<br />
(n = 344)<br />
Case fatality rate: 7/361 (2%) Case fatality rate: 6/344 (2%)<br />
All complications: 135/361 (37%) All complications: 173/346 (50%)<br />
Infections: 120/361 (33%) Infections: 144/346 (42%)<br />
Primary anastomosis<br />
(n = 197)<br />
Ileostomy<br />
(n = 100)<br />
Case fatality rate: 8/197 (4%) Case fatality rate: 10/100 (10%)<br />
All complications: 44/197 (22%) All complications: 27/100 (27%)<br />
Infections: 33/197 (17%) Infections: 21/100 (21%)<br />
Primary anastomosis<br />
(n = 38)<br />
Ileostomy<br />
(n = 27)<br />
Case fatality rate: 1/38 (2%) Case fatality rate: 0/27 (0%)<br />
all colon-associated complications: 11/38 (29%) all colon-associated complications: 10/27 (37%)<br />
Infections: 5/38 (13%) Infections: 9/27 (33%)<br />
Emergency surgery phase - Abdomen 329
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 23: Hand suture versus stapler after penetrating colon injury<br />
Study LoE Patients Result<br />
Brundage et<br />
al. 2001<br />
[95]<br />
Demetriades<br />
et al. 2002<br />
[96]<br />
2b 29 patients with blunt and<br />
penetrating colon injuries<br />
2b 207 patients with<br />
penetrating colon injuries<br />
Hand suture<br />
(n = 12)<br />
Emergency surgery phase - Abdomen 330<br />
Stapler<br />
(n = 17)<br />
All complications: 2/12 (16%) All complications: 6/17 (35%)<br />
Anastomosis failure: 0/12 (0%) Anastomosis failure: 3/17 (18%)<br />
Abscess: 2/12 (17%) Abscess: 5/17 (29%)<br />
Hand suture:<br />
(n = 128)<br />
Stapler:<br />
(n = 79)<br />
All complications: 26/128 (20%) All complications: 21/79 (27%)<br />
Anastomosis failure: 10/128 (8%) Anastomosis failure: 5/79 (6%)<br />
Abscess: 20/128 (16%) Abscess: 16/79 (20%)
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 24: Hand suture versus stapler after penetrating colon injury<br />
Study LoE Patients Result<br />
Brundage<br />
et al. 1999<br />
[95]<br />
Kirkpatrick<br />
AW et al.<br />
2003 [97]<br />
2b 117 patients with blunt<br />
and penetrating small<br />
intestine injuries<br />
2b 232 patients with blunt<br />
and penetrating small<br />
intestine injuries<br />
Hand suture<br />
(n = 44)<br />
Emergency surgery phase - Abdomen 331<br />
Stapler<br />
(n = 70)<br />
All complications: 2/44 (5%) All complications: 8/70 (11%)<br />
Anastomosis failure: 0/44 (0%) Anastomosis failure: 3/70 (4%)<br />
Abscess: 0/44 (0%) Abscess: 6/70 (9%)<br />
Hand suture<br />
(n = 25)<br />
Stapler<br />
(n = 55)<br />
All complications: 4/25 (16%) All complications: 7/55 (13%)<br />
Anastomosis failure: 1/25 (4%) Anastomosis failure: 3/55 (6%)<br />
Abscess: 3/25 (12%) Abscess: 6/55 (11%)
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Cothren CC, Moore EE, Hoyt DB. The U.S. trauma<br />
surgeon's current scope of practice: can we deliver<br />
acute care surgery? J Trauma 2008;64(4):955-965.<br />
2. Hoyt DB, Kim HD, Barrios C. Acute care surgery: a<br />
new training and practice model in the United States.<br />
World J Surg 2008;32(8):1630-1635.<br />
3. Hess JR, Holcomb JB, Hoyt DB. Damage control<br />
resuscitation: the need for specific blood products to<br />
treat the coagulopathy of trauma. Transfusion<br />
2006;46(5):685-686.<br />
4. Hodgetts TJ, Mahoney PF, Kirkman E. Damage<br />
control resuscitation. J R Army Med Corps<br />
2007;153(4):299-300.<br />
5. Holcomb JB, Jenkins D, Rhee P et al. Damage control<br />
resuscitation: directly addressing the early<br />
coagulopathy of trauma. J Trauma 2007;62(2):307-<br />
310.<br />
6. Jansen JO, Thomas R, Loudon MA, Brooks A.<br />
Damage control resuscitation for patients with major<br />
trauma. BMJ 2009;338b1778.<br />
7. Tieu BH, Holcomb JB, Schreiber MA. Coagulopathy:<br />
its pathophysiology and treatment in the injured<br />
patient. World J Surg 2007;31(5):1055-1064.<br />
8. Edwards PS, Lipp A, Holmes A. Preoperative skin<br />
antiseptics for preventing surgical wound infections<br />
after clean surgery. Cochrane Database Syst Rev<br />
2004(3):CD003949.<br />
9. Clarke JM. Case for midline incisions. Lancet<br />
1989;1(8638):622 [LoE 5].<br />
10. Guillou PJ, Hall TJ, Donaldson DR, Broughton AC,<br />
Brennan TG. Vertical abdominal incisions--a choice?<br />
Br J Surg 1980;67(6):395-399 [LoE 5].<br />
11. Stone HH, Hoefling SJ, Strom PR, Dunlop WE,<br />
Fabian TC. Abdominal incisions: transverse vs<br />
vertical placement and continuous vs interrupted<br />
closure. South Med J 1983;76(9):1106-1108 [LoE 2b].<br />
12. Brown SR, Goodfellow PB. Transverse verses midline<br />
incisions for abdominal surgery. Cochrane Database<br />
Syst Rev 2005(4):CD005199 [LoE 1a].<br />
13. Seiler CM, Deckert A, Diener MK et al. Midline<br />
versus transverse incision in major abdominal surgery:<br />
a randomized, double-blind equivalence trial<br />
(POVATI: ISRCTN60734227). Ann Surg<br />
2009;249(6):913-920 [LoE 1b].<br />
14. Hori Y. Diagnostic laparoscopy guidelines : This<br />
guideline was prepared by the SAGES Guidelines<br />
Committee and reviewed and approved by the Board<br />
of Governors of the Society of American<br />
Gastrointestinal and Endoscopic Surgeons (SAGES),<br />
November 2007. Surg Endosc 2008;22(5):1353-1383<br />
[Evidenzbasierte Leitlinie]<br />
15. Sauerland S, Agresta F, Bergamaschi R et al.<br />
Laparoscopy for abdominal emergencies: evidencebased<br />
guidelines of the European Association for<br />
Endoscopic Surgery. Surg Endosc 2006;20(1):14-29<br />
[Evidenzbasierte Leitlinie]<br />
16. Chol YB, Lim KS. Therapeutic laparoscopy for<br />
abdominal trauma. Surg Endosc 2003;17(3):421-427<br />
[LoE 4].<br />
17. Kaban GK, Novitsky YW, Perugini RA et al. Use of<br />
laparoscopy in evaluation and treatment of penetrating<br />
and blunt abdominal injuries. Surg Innov<br />
2008;15(1):26-31 [LoE 4].<br />
18. Mallat AF, Mancini ML, Daley BJ, Enderson BL. The<br />
role of laparoscopy in trauma: a ten-year review of<br />
diagnosis and therapeutics. Am Surg<br />
2008;74(12):1166-1170 [LoE 4].<br />
19. Smith RS, Fry WR, Morabito DJ, Koehler RH, Organ<br />
CH, Jr. Therapeutic laparoscopy in trauma. Am J Surg<br />
1995;170(6):632-636 [LoE 4].<br />
20. Zantut LF, Ivatury RR, Smith RS et al. Diagnostic and<br />
therapeutic laparoscopy for penetrating abdominal<br />
trauma: a multicenter experience. J Trauma<br />
1997;42(5):825-829 [LoE 4].<br />
21. Committee on Technology for Future Naval Forces.<br />
Technology for the United States Navy and Marine<br />
Corps, 2000-2035. Becoming a 21st-Century Force.<br />
1997.<br />
22. Rotondo MF, Zonies DH. The Damage Control<br />
sequence and underlying logic. Surg Clin North Am<br />
1997;77(4):761-777.<br />
23. Germanos S, Gourgiotis S, Villias C et al. Damage<br />
control surgery in the abdomen: an approach for the<br />
management of severe injured patients. Int J Surg<br />
2008;6(3):246-252.<br />
24. Lee JC, Peitzman AB. Damage-control laparotomy.<br />
Curr Opin Crit Care 2006;12(4):346-350.<br />
25. Loveland JA, Boffard KD. Damage control in the<br />
abdomen and beyond. Br J Surg 2004;91(9):1095-<br />
1101.<br />
26. Kremer B, Henne-Bruns D. [Value of various<br />
techniques in liver rupture]. Chirurg 1993;64(11):852-<br />
859 [LoE 4].<br />
27. Feliciano DV, Mattox KL, Burch JM, Bitondo CG,<br />
Jordan GL, Jr. Packing for control of hepatic<br />
hemorrhage. J Trauma 1986;26(8):738-743 [LoE 4].<br />
28. Feliciano DV, Mattox KL, Jordan GL, Jr. Intraabdominal<br />
packing for control of hepatic hemorrhage:<br />
a reappraisal. J Trauma 1981;21(4):285-290 [LoE 4].<br />
29. Baracco-Gandolfo V, Vidarte O, Baracco-Miller V,<br />
del Castillo M. Prolonged closed liver packing in<br />
severe hepatic trauma: experience with 36 patients. J<br />
Trauma 1986;26(8):754-756 [LoE 4].<br />
30. Reed RL, Merrell RC, Meyers WC, Fischer RP.<br />
Continuing evolution in the approach to severe liver<br />
trauma. Ann Surg 1992;216(5):524-538 [LoE 4].<br />
31. Stone HH, Strom PR, Mullins RJ. Management of the<br />
major coagulopathy with onset during laparotomy.<br />
Ann Surg 1983;197(5):532-535 [LoE 2b].<br />
32. Rotondo MF, Schwab CW, McGonigal MD et al.<br />
'Damage control': an approach for improved survival<br />
in exsanguinating penetrating abdominal injury. J<br />
Trauma 1993;35(3):375-382 [LoE 2b].<br />
33. MacKenzie S, Kortbeek JB, Mulloy R, Hameed SM.<br />
Recent experiences with a multidisciplinary approach<br />
to complex hepatic trauma. Injury 2004;35(9):869-877<br />
[LoE 2b].<br />
Emergency surgery phase - Abdomen 332
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
34. Nicholas JM, Rix EP, Easley KA et al. Changing<br />
patterns in the management of penetrating abdominal<br />
trauma: the more things change, the more they stay<br />
the same. J Trauma 2003;55(6):1095-1108 [LoE 2b].<br />
35. Cirocchi R, Abraha I, Montedori A, Farinella E,<br />
Bonacini I, Tagliabue L, Sciannameo F. Damage<br />
control surgery for abdominal trauma. Cochrane<br />
Database of Systematic Reviews 2010, Issue 1. Art.<br />
No.: CD007438. DOI: 10.1002/14651858.<br />
CD007438.pub2<br />
36. Johnson JW, Gracias VH, Schwab CW et al.<br />
Evolution in Damage Control for exsanguinating<br />
penetrating abdominal injury. J Trauma<br />
2001;51(2):261-269 [LoE 4].<br />
37. Shapiro MB, Jenkins DH, Schwab CW, Rotondo MF.<br />
Damage control: collective review. J Trauma<br />
2000;49(5):969-978 [LoE 4].<br />
38. Arvieux C, Cardin N, Chiche L et al. La laparotomie<br />
écourtée dans les traumatismes abdominaux<br />
hémorragiques. Étude multicentrique rétrospective sur<br />
109 cas. Ann Chir 2003;128(3):150-158 [LoE 4].<br />
39. Asensio JA, Petrone P, Roldan G et al. Has evolution<br />
in awareness of guidelines for institution of Damage<br />
Control improved outcome in the management of the<br />
posttraumatic open abdomen? Arch Surg<br />
2004;139(2):209-214 [LoE 4].<br />
40. Pringle JH. V. Notes on the Arrest of Hepatic<br />
Hemorrhage Due to Trauma. Ann Surg<br />
1908;48(4):541-549 [LoE 5].<br />
41. Kremer B, Henne-Bruns D. [Value of various<br />
techniques in liver rupture]. Chirurg 1993;64(11):852-<br />
859 [LoE 5].<br />
42. Gao JM, Du DY, Zhao XJ et al. Liver trauma:<br />
experience in 348 cases. World J Surg<br />
2003;27(6):703-708 [LoE 4].<br />
43. Offner PJ, de Souza AL, Moore EE et al. Avoidance<br />
of abdominal compartment syndrome in damagecontrol<br />
laparotomy after trauma. Arch Surg<br />
2001;136(6):676-681 [LoE 2b].<br />
44. Aprahamian C, Wittmann DH, Bergstein JM,<br />
Quebbeman EJ. Temporary abdominal closure (TAC)<br />
for planned relaparotomy (etappenlavage) in trauma. J<br />
Trauma 1990;30(6):719-723.<br />
45. Boele vH, Wind J, Dijkgraaf MG, Busch OR, Carel<br />
GJ. Temporary closure of the open abdomen: a<br />
systematic review on delayed primary fascial closure<br />
in patients with an open abdomen. World J Surg<br />
2009;33(2):199-207 [LoE 4].<br />
46. Weinberg JA, George RL, Griffin RL et al. Closing<br />
the open abdomen: improved success with Wittmann<br />
Patch staged abdominal closure. J Trauma<br />
2008;65(2):345-348 [LoE 2b].<br />
47. Bee TK, Croce MA, Magnotti LJ et al. Temporary<br />
abdominal closure techniques: a prospective<br />
randomized trial comparing polyglactin 910 mesh and<br />
vacuum-assisted closure. J Trauma 2008;65(2):337-<br />
342 [LoE 1b].<br />
48. Nicol AJ, Hommes M, Primrose R, Navsaria PH,<br />
Krige JE. Packing for control of hemorrhage in major<br />
liver trauma. World J Surg 2007;31(3):569-574 [LoE<br />
2b].<br />
49. Caruso DM, Battistella FD, Owings JT, Lee SL,<br />
Samaco RC. Perihepatic packing of major liver<br />
injuries: complications and mortality. Arch Surg<br />
1999;134(9):958-962 [LoE 2b].<br />
50. Abikhaled JA, Granchi TS, Wall MJ, Hirshberg A,<br />
Mattox KL. Prolonged abdominal packing for trauma<br />
is associated with increased morbidity and mortality.<br />
Am Surg 1997;63(12):1109-1112 [LoE 2b].<br />
51. Cue JI, Cryer HG, Miller FB, Richardson JD, Polk<br />
HC, Jr. Packing and planned reexploration for hepatic<br />
and retroperitoneal hemorrhage: critical refinements<br />
of a useful technique. J Trauma 1990;30(8):1007-<br />
1011 [LoE 2b].<br />
52. Sharp KW, Locicero RJ. Abdominal packing for<br />
surgically uncontrollable hemorrhage. Ann Surg<br />
1992;215(5):467-474.<br />
53. Hodgson NC, Malthaner RA, Ostbye T. The search<br />
for an ideal method of abdominal fascial closure: a<br />
meta-analysis. Ann Surg 2000;231(3):436-442 [LoE<br />
1a].<br />
54. van 't RM, Steyerberg EW, Nellensteyn J, Bonjer HJ,<br />
Jeekel J. Meta-analysis of techniques for closure of<br />
midline abdominal incisions. Br J Surg<br />
2002;89(11):1350-1356 [LoE 1a].<br />
55. Seiler CM, Bruckner T, Diener MK et al. Interrupted<br />
or continuous slowly absorbable sutures for closure of<br />
primary elective midline abdominal incisions: a<br />
multicenter randomized trial (INSECT:<br />
ISRCTN24023541). Ann Surg 2009;249(4):576-582<br />
[LoE 1b].<br />
56. Dondelinger RF, Trotteur G, Ghaye B, Szapiro D.<br />
Traumatic injuries: radiological hemostatic<br />
intervention at admission. Eur Radiol 2002;12(5):979-<br />
993.<br />
57. Lin BC, Wong YC, Lim KE et al. Management of<br />
ongoing arterial haemorrhage after Damage Control<br />
laparotomy: Optimal timing and efficacy of<br />
transarterial embolisation. Injury 2009.<br />
58. Hagiwara A, Murata A, Matsuda T, Matsuda H,<br />
Shimazaki S. The usefulness of transcatheter arterial<br />
embolization for patients with blunt polytrauma<br />
showing transient response to fluid resuscitation. J<br />
Trauma 2004;57(2):271-276 [LoE 4].<br />
59. Raikhlin A, Baerlocher MO, Asch MR, Myers A.<br />
Imaging and transcatheter arterial embolization for<br />
traumatic splenic injuries: review of the literature. Can<br />
J Surg 2008;51(6):464-472 [LoE 4].<br />
60. Asensio JA, Roldan G, Petrone P et al. Operative<br />
management and outcomes in 103 AAST-OIS grades<br />
IV and V complex hepatic injuries: trauma surgeons<br />
still need to operate, but angioembolization helps. J<br />
Trauma 2003;54(4):647-653 [LoE 2b].<br />
61. Asensio JA, Petrone P, Garcia-Nunez L, Kimbrell B,<br />
Kuncir E. Multidisciplinary approach for the<br />
management of complex hepatic injuries AAST-OIS<br />
grades IV-V: a prospective study. Scand J Surg<br />
2007;96(3):214-220 [LoE 2b].<br />
62. Johnson JW, Gracias VH, Gupta R et al. Hepatic<br />
angiography in patients undergoing Damage Control<br />
laparotomy. J Trauma 2002;52(6):1102-1106 [LoE<br />
2b].<br />
Emergency surgery phase - Abdomen 333
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
63. Mohr AM, Lavery RF, Barone A et al. Angiographic<br />
embolization for liver injuries: low mortality, high<br />
morbidity. J Trauma 2003;55(6):1077-1081 [LoE 2b].<br />
64. Monnin V, S<strong>eng</strong>el C, Thony F et al. Place of arterial<br />
embolization in severe blunt hepatic trauma: a<br />
multidisciplinary approach. Cardiovasc Intervent<br />
Radiol 2008;31(5):875-882 [LoE 2b].<br />
65. Wahl WL, Ahrns KS, Brandt MM, Franklin GA,<br />
Taheri PA. The need for early angiographic<br />
embolization in blunt liver injuries. J Trauma<br />
2002;52(6):1097-1101 [LoE 2b].<br />
66. Velmahos GC, Chahwan S, Falabella A, Hanks SE,<br />
Demetriades D. Angiographic embolization for<br />
intraperitoneal and retroperitoneal injuries. World J<br />
Surg 2000;24(5):539-545 [LoE 2b].<br />
67. Harbrecht BG, Ko SH, Watson GA et al. Angiography<br />
for blunt splenic trauma does not improve the success<br />
rate of nonoperative management. J Trauma<br />
2007;63(1):44-49 [LoE 2b].<br />
68. Smith HE, Biffl WL, Majercik SD et al. Splenic artery<br />
embolization: Have we gone too far? J Trauma<br />
2006;61(3):541-544 [LoE 2b].<br />
69. Cooney R, Ku J, Cherry R et al. Limitations of splenic<br />
angioembolization in treating blunt splenic injury. J<br />
Trauma 2005;59(4):926-932 [LoE 2b].<br />
70. Duchesne JC, Simmons JD, Schmieg RE, Jr.,<br />
McSwain NE, Jr., Bellows CF. Proximal splenic<br />
angioembolization does not improve outcomes in<br />
treating blunt splenic injuries compared with<br />
splenectomy: a cohort analysis. J Trauma<br />
2008;65(6):1346-1351 [LoE 2b].<br />
71. Wei B, Hemmila MR, Arbabi S, Taheri PA, Wahl<br />
WL. Angioembolization reduces operative<br />
intervention for blunt splenic injury. J Trauma<br />
2008;64(6):1472-1477.<br />
72. Velanovich V. Blunt splenic injury in adults: a<br />
decision analysis comparing options for treatment.<br />
Eur J Surg 1995;161(7):463-470.<br />
73. Peitzman AB, Ford HR, Harbrecht BG, Potoka DA,<br />
Townsend RN. Injury to the spleen. Curr Probl Surg<br />
2001;38(12):932-1008 [LoE 5].<br />
74. Clancy TV, Ramshaw DG, Maxwell JG et al.<br />
Management outcomes in splenic injury: a statewide<br />
trauma center review. Ann Surg 1997;226(1):17-24<br />
[LoE 2b].<br />
75. Gauer JM, Gerber-Paulet S, Seiler C, Schweizer WP.<br />
Twenty years of splenic preservation in trauma: lower<br />
early infection rate than in splenectomy. World J Surg<br />
2008;32(12):2730-2735 [LoE 2b].<br />
76. Kaseje N, Agarwal S, Burch M et al. Short-term<br />
outcomes of splenectomy avoidance in trauma<br />
patients. Am J Surg 2008;196(2):213-217 [LoE 2b].<br />
77. Feliciano DV, Bitondo CG, Mattox KL et al. A fouryear<br />
experience with splenectomy versus<br />
splenorrhaphy. Ann Surg 1985;201(5):568-575 [LoE<br />
4].<br />
78. Hunt JP, Lentz CW, Cairns BA et al. Management<br />
and outcome of splenic injury: the results of a fiveyear<br />
statewide population-based study. Am Surg<br />
1996;62(11):911-917 [LoE 2b].<br />
79. Carlin AM, Tyburski JG, Wilson RF, Steffes C.<br />
Factors affecting the outcome of patients with splenic<br />
trauma. Am Surg 2002;68(3):232-239 [LoE 2b].<br />
80. Aidonopoulos AP, Papavramidis ST, Goutzamanis<br />
GD et al. Splenorrhaphy for splenic damage in<br />
patients with multiple injuries. Eur J Surg<br />
1995;161(4):247-251 [LoE 4].<br />
81. Clancy TV, Ramshaw DG, Maxwell JG et al.<br />
Management outcomes in splenic injury: a statewide<br />
trauma center review. Ann Surg 1997;226(1):17-24.<br />
82. Gauer JM, Gerber-Paulet S, Seiler C, Schweizer WP.<br />
Twenty years of splenic preservation in trauma: lower<br />
early infection rate than in splenectomy. World J Surg<br />
2008;32(12):2730-2735.<br />
83. Kaseje N, Agarwal S, Burch M et al. Short-term<br />
outcomes of splenectomy avoidance in trauma<br />
patients. Am J Surg 2008;196(2):213-217.<br />
84. Velmahos GC, Demetriades D, Toutouzas KG et al.<br />
Selective nonoperative management in 1,856 patients<br />
with abdominal gunshot wounds: should routine<br />
laparotomy still be the standard of care? Ann Surg<br />
2001;234(3):395-402 [LoE 2b].<br />
85. Chappuis CW, Frey DJ, Dietzen CD et al.<br />
Management of penetrating colon injuries. A<br />
prospective randomized trial. Ann Surg<br />
1991;213(5):492-497 [LoE 1b].<br />
86. Falcone RE, Wanamaker SR, Santanello SA, Carey<br />
LC. Colorectal trauma: primary repair or anastomosis<br />
with intracolonic bypass vs. ostomy. Dis Colon<br />
Rectum 1992;35(10):957-963 [LoE 1b].<br />
87. Gonzalez RP, Falimirski ME, Holevar MR. Further<br />
evaluation of colostomy in penetrating colon injury.<br />
Am Surg 2000;66(4):342-346 [LoE 1b].<br />
88. Kamwendo NY, Modiba MC, Matlala NS, Becker PJ.<br />
Randomized clinical trial to determine if delay from<br />
time of penetrating colonic injury precludes primary<br />
repair. Br J Surg 2002;89(8):993-998 [LoE 1b].<br />
89. Sasaki LS, Allaben RD, Golwala R, Mittal VK.<br />
Primary repair of colon injuries: a prospective<br />
randomized study. J Trauma 1995;39(5):895-901<br />
[LoE 1b].<br />
90. Stone HH, Fabian TC. Management of perforating<br />
colon trauma: randomization between primary closure<br />
and exteriorization. Ann Surg 1979;190(4):430-436<br />
[LoE 1b].<br />
91. Nelson R, Singer M. Primary repair for penetrating<br />
colon injuries. Cochrane Database Syst Rev<br />
2002(3):CD002247 [LoE 1a].<br />
92. Demetriades D, Murray JA, Chan L et al. Penetrating<br />
colon injuries requiring resection: diversion or<br />
primary anastomosis? An AAST prospective<br />
multicenter study. J Trauma 2001;50(5):765-775 [LoE<br />
2b].<br />
93. Vertrees A, Wakefield M, Pickett C et al. Outcomes<br />
of primary repair and primary anastomosis in warrelated<br />
colon injuries. J Trauma 2009;66(5):1286-<br />
1291 [LoE 2b].<br />
94. Lustosa SA, Matos D, Atallah AN, Castro AA.<br />
Stapled versus handsewn methods for colorectal<br />
anastomosis surgery. Cochrane Database Syst Rev<br />
2001(3):CD003144 [LoE 1a].<br />
Emergency surgery phase - Abdomen 334
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
95. Brundage SI, Jurkovich GJ, Hoyt DB et al. Stapled<br />
versus sutured gastrointestinal anastomoses in the<br />
trauma patient: a multicenter trial. J Trauma<br />
2001;51(6):1054-1061 [LoE 2b].<br />
96. Demetriades D, Murray JA, Chan LS et al. Handsewn<br />
versus stapled anastomosis in penetrating colon<br />
injuries requiring resection: a multicenter study. J<br />
Trauma 2002;52(1):117-121 [LoE 2b].<br />
97. Kirkpatrick AW, Baxter KA, Simons RK et al. Intraabdominal<br />
complications after surgical repair of small<br />
bowel injuries: an international review. J Trauma<br />
2003;55(3):399-406 [LoE 2b].<br />
98. Burch JM, Franciose RJ, Moore EE, Biffl WL, Offner<br />
PJ. Single-layer continuous versus two-layer<br />
interrupted intestinal anastomosis: a prospective<br />
randomized trial. Ann Surg 2000;231(6):832-837<br />
[LoE 1b]<br />
Emergency surgery phase - Abdomen 335
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.5 Traumatic brain injury<br />
Surgical management<br />
Emergency surgical management<br />
Key recommendation:<br />
Compressive intracranial injuries must be surgically managed as an<br />
emergency.<br />
Explanation:<br />
GoR A<br />
The goal of the treatment after a TBI is to limit the extent of secondary brain damage and to<br />
provide the brain cells whose function is impaired but not destroyed with the best conditions for<br />
functional regeneration. Injury sequelae requiring surgery must be treated in a timely manner.<br />
The indication for surgical decompression of traumatic intracranial compression has never been<br />
tested in prospective randomized controlled trials. There are several retrospective analyses [3-9,<br />
13] from which the benefit of surgical decompression can be derived. Due to the decades of<br />
consensual experience, the need for a surgical procedure can be regarded as a basic<br />
incontrovertible assumption of good clinical practice.<br />
Compressive intracranial injuries represent an absolute urgent indication for surgery. This<br />
applies both to traumatic intracranial bleeding (epidural hematoma, subdural hematoma,<br />
intracerebral hematoma/contusion) and to compressive impression fractures. The definition of<br />
compression refers to the shift of cerebral structures, particularly the 3rd ventricle normally<br />
located at the midline. In addition to the finding in the computed tomography (layer thickness,<br />
volume, and location of hematoma, extent of midline shift), the clinical finding is key to<br />
establishing the indication and the speed with which surgical management should be carried out.<br />
If there are signs of a transtentorial herniation, every minute can make a difference to the clinical<br />
outcome. It is not considered meaningful to indicate the volumes at which an intervention should<br />
be performed as the individual situation of the patient (age, possible pre-existing brain atrophy<br />
inter alia) must be taken into account in establishing the indication.<br />
Operations with deferred urgency<br />
Open or closed impression fractures without shift of midline structures, penetrating injuries or<br />
basal fractures with liquorrhea constitute operations with deferred urgency. Their surgical<br />
conduct requires neurosurgical competence. The timing of the surgical intervention depends on<br />
many factors and must be decided on an individual basis.<br />
Decompressive craniectomy<br />
An effective option for lowering elevated intracranial pressure is surgical decompression by<br />
craniectomy and, if necessary, expansive duraplasty. The necessity mainly arises from the<br />
Emergency surgery phase – Traumatic brain injury 336
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
development of marked (secondary) brain edema and thus frequently has several days’ latency.<br />
According to a prospective randomized controlled trial, the method shows good treatment<br />
success despite an increased complication rate [23]. Further prospective studies [10, 18] are<br />
ongoing so that no <strong>final</strong> recommendation can yet be made [26].<br />
Nonoperative treatment of intracranial bleeding<br />
In noncompressive bleeding and stable neurologic finding, a nonoperative procedure can be<br />
justified in individual cases [5, 7]. However, these patients must undergo close clinical and<br />
computed tomography follow-up observation. In the event of clinical deterioration or increase in<br />
compression, it must be possible to carry out immediate surgical decompression.<br />
Measuring intracranial pressure<br />
Key recommendation:<br />
Intracranial pressure can be measured in unconscious brain-damaged<br />
patients.<br />
Explanation:<br />
GoR 0<br />
Internationally in recent decades, the measurement of intracranial pressure has found its way into<br />
the acute management of unconscious brain-damaged patients and has meanwhile been adopted<br />
in several international guidelines [2, 21, 30]. For pathophysiologic reasons, this seems sensible<br />
as clinical monitoring of many cerebral functions is only possible to a limited extent. As a<br />
monitoring instrument in sedated patients, it can indicate imminent midbrain incarceration due to<br />
progressive brain swelling or compressive intracranial hematomas and thus permits early<br />
counter-measures to be taken. Even if there is currently no prospective randomized controlled<br />
trial that compares the clinical outcome with carrying out ICP monitoring [15], several cohort<br />
studies in recent years as well as clinical practice indicate its value in neurosurgical intensive<br />
medicine [1, 17, 20, 22]. The introduction of guidelines which, inter alia, stipulate this type of<br />
ICP monitoring has also led to an increase in favorable courses in TBI patients [24, 11].<br />
Intracranial measurement is used for monitoring and treatment control of unconscious patients<br />
while taking into account the clinical course and morphologic image findings after TBI.<br />
However, it is not required in every unconscious patient.<br />
The prerequisite for adequate brain perfusion is adequate cerebral perfusion pressure (CPP),<br />
which can be calculated simply from the difference between the mean arterial blood pressure and<br />
the mean ICP. The literature contains divergent opinions on whether lowering the ICP or<br />
maintaining the CPP should be the focus of the treatment in the case of elevated ICP. The<br />
currently available evidence argues in favor that,<br />
� on the one hand, the CPP should not fall below 50 mmHg if possible [30].<br />
� on the other hand, the CPP should not be raised to above 70 mmHg by aggressive treatment<br />
[30].<br />
Emergency surgery phase – Traumatic brain injury 337
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Invasive ICP measurement is necessary for continuous determination of the CPP. Provided the<br />
ventricles are not completely compressed, ICP monitoring via a ventricle drain offers the<br />
possibility of lowering elevated ICP through draining cerebrospinal fluid.<br />
Determining the individual optimum CPP requires simultaneous knowledge of brain blood<br />
supply, oxygen supply and demand and/or brain metabolism. Regional measurements (using<br />
brain tissue probes, transcranial Doppler examinations or perfusion-weighted imaging) for<br />
estimating this value are currently the subject of scientific studies [19, 27].<br />
Emergency surgery phase – Traumatic brain injury 338
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Balestreri M, Czosnyka M, Hutchinson P, et al:<br />
Impact of intracranial pressure and cerebral perfusion<br />
pressure on severe disability and mortality after head<br />
injury. Neurocrit.Care 4:8-13, 2006<br />
2. Bullock R, Chesnut RM, Clifton G, et al: Guidelines<br />
for the management of severe head injury. Brain<br />
Trauma Foundation. Eur.J.Emerg.Med. 3:109-127,<br />
1996 [Evidenzbasierte Leitlinie]<br />
3. Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R,<br />
Newell D, Servadei F, Walters BC, Wilberger JE.<br />
Introduction. Neurosurgery. Guidelines for the<br />
Surgical Management of Traumatic Brain Injury.<br />
58(3) Supplement:S2-1-S2-3, March 2006<br />
[Evidenzbasierte Leitlinie].<br />
4. Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R,<br />
Newell D, Servadei F, Walters BC, Wilberger JE.<br />
Methodology. Guidelines for the Surgical<br />
Management of Traumatic Brain Injury. Neurosurgery<br />
58 Supplement: March 2006 [Evidenzbasierte<br />
Leitlinie]<br />
5. Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R,<br />
Newell D, Servadei F, Walters BC, Wilberger JE.<br />
Surgical Management of Acute Epidural Hematomas.<br />
Guidelines for the Surgical Management of Traumatic<br />
Brain Injury. Neurosurgery 58 Supplement, March<br />
2006 [Evidenzbasierte Leitlinie]<br />
6. Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R,<br />
Newell D, Servadei F, Walters BC, Wilberger JE.<br />
Surgical Management of Acute Subdural Hematomas.<br />
Guidelines for the Surgical Management of Traumatic<br />
Brain Injury. Neurosurgery 58 Supplement, March<br />
2006 [Evidenzbasierte Leitlinie]<br />
7. Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R,<br />
Newell D, Servadei F, Walters BC, Wilberger JE.<br />
Surgical Management of Traumatic Parenchymal<br />
Lesions. Guidelines for the Surgical Management of<br />
Traumatic Brain Injury. Neurosurgery 58,<br />
Supplement, March 2006 [Evidenzbasierte Leitlinie]<br />
8. Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R,<br />
Newell D, Servadei F, Walters BC, Wilberger JE.<br />
Surgical Management of Posterior Fossa Mass<br />
Lesions. Guidelines for the Surgical Management of<br />
Traumatic Brain Injury. Neurosurgery 58 Supplement,<br />
March 2006 [Evidenzbasierte Leitlinie]<br />
9. Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R,<br />
Newell D, Servadei F, Walters BC, Wilberger JE.<br />
Surgical Management of Depressed Cranial Fractures.<br />
Guidelines for the Surgical Management of Traumatic<br />
Brain Injury. Neurosurgery 58 Supplement, March<br />
2006 [Evidenzbasierte Leitlinie]<br />
10. Cooper DJ, Rosenfeld JV, Murray L, Wolfe R,<br />
Ponsford J, Davies A, D'Urso P, Pellegrino V,<br />
Malham G, Kossmann T. Early decompressive<br />
craniectomy for patients with severe traumatic brain<br />
injury and refractory intracranial hypertension‐a pilot<br />
randomized trial. J Crit Care. 2008:387-93.<br />
11. Fakhry SM, Trask AL, Waller MA, et al.: IRTC<br />
Neurotrauma Task Force.: Management of braininjured<br />
patients by an evidence-based medicine<br />
protocol improves outcomes and decreases hospital<br />
charges. J Trauma. 56(3): 492-93, 2004<br />
12. Fernandez R, Firsching R, Lobato R, Mathiesen T,<br />
Pickard J, Servadei F, Tomei G, Brock M, Cohadon F,<br />
Rosenorn J: Guidelines for treatment of head injury in<br />
adults. Zentrbl Neuroch, 72-74, 1997 [Evidenzbasierte<br />
Leitlinie]<br />
13. Firsching R, Heimann M, Frowein RA. Early<br />
dyna<strong>mc</strong>is of extradural and subdural hematomas.<br />
Neurol Res 19: 257–60, 1997.<br />
14. Firsching R, Messing-Jünger M, Rickels E, Gräber S<br />
und Schwerdtfeger K. Leitlinie Schädelhirntrauma im<br />
Erwachsenenalter der Deutschen Gesellschaft für<br />
Neurochirurgie. AWMF online 2007.<br />
http://www.uni-duesseldorf.de/AWMF/ll/008-<br />
001.htm [LoE 3a].<br />
15. Forsyth RJ,Wolny S, Rodrigues B. Routine<br />
intracranial pressure monitoring in acute coma.<br />
Cochrane Database of Systematic Reviews 2010,<br />
Issue 2.<br />
16. Gabriel EJ, Ghajar J, Jagoda A, Pons PT, Scalea T,<br />
Walters BC; Brain Trauma Foundation. Guidelines for<br />
prehospital management of traumatic brain injury. J<br />
Neurotrauma. 19:111-74, 2002 [Evidenzbasierte<br />
Leitlinie]<br />
17. Hiler M, Czosnyka M, Hutchinson P, et al: Predictive<br />
value of initial computerized tomography scan,<br />
intracranial pressure, and state of autoregulation in<br />
patients with traumatic brain injury. J.Neurosurg.<br />
104:731-737, 2006<br />
18. Hutchinson PJ, Corteen E, Czosnyka M, Mendelow<br />
AD, Menon DK, Mitchell P, Murray G, Pickard JD,<br />
Rickels E, Sahuquillo J, Servadei F, Teasdale GM,<br />
Timofeev I, Unterberg A, Kirkpatrick PJ.<br />
Decompressive craniectomy in traumatic brain injury:<br />
the randomized multicenter RESCUEicp study<br />
(www.RESCUEicp.com). Acta Neurochir Suppl.<br />
2006;96:17-20.<br />
19. Jaeger M, Schuhmann MU, Soehle M, et al:<br />
Continuous assessment of cerebrovascular<br />
autoregulation after traumatic brain injury using brain<br />
tissue oxygen pressure reactivity. Crit Care Med.<br />
34:1783-1788, 2006<br />
20. Lane PL, Skoretz TG, Doig G, et al: Intracranial<br />
pressure monitoring and outcomes after traumatic<br />
brain injury. Can.J.Surg. 43:442-448, 2000.<br />
21. Maas, A. et al.: EBIC-Guidelines for mangement of<br />
severe head injury in adults. Acta Neurchir. (Wien)<br />
139, 286-294, 1997 [Evidenzbasierte Leitlinie]<br />
22. Mauritz W, Janciak I, Wilbacher I, et al: Severe<br />
Traumatic Brain Injury in Austria IV: Intensive care<br />
management. Wien.Klin.Wochenschr. 119:46-55,<br />
2007.<br />
23. Qiu W, Guo C, Shen H, Chen K, Wen L, Huang H,<br />
Ding M, Sun L, Jiang Q, Wang W. Effects of<br />
unilateral decompressive craniectomy on patients with<br />
Emergency surgery phase – Traumatic brain injury 339
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
unilateral acute post‐traumatic brain swelling after<br />
severe traumatic brain injury. Crit Care.<br />
2009;13(6):R185. Epub 2009 Nov 23.<br />
24. Palmer S, Bader MK, Qureshi A, et al: The impact on<br />
outcomes in a community hospital setting of using the<br />
AANS traumatic brain injury guidelines. Americans<br />
Associations for Neurologic Surgeons. J.Trauma<br />
50:657-664, 2001 [Evidenzbasierte Leitlinie]<br />
25. Rotondo MF, Schwab CW, McGonigal MD, et al.:<br />
“Damage control”: an approach for improved survival<br />
in exsanguinating penetrating abdominal injury. J<br />
Trauma 1993, 35:375–382.<br />
26. Sahuquillo J, Arikan F. Decompressive craniectomy<br />
for the treatment of refractory high intracranial<br />
pressure in traumatic brain injury. The Cochrane<br />
Database of Systematic Reviews 2006, Issue 1.<br />
27. Steiner LA, Czosnyka M, Piechnik SK, et al:<br />
Continuous monitoring of cerebrovascular pressure<br />
reactivity allows determination of optimal cerebral<br />
perfusion pressure in patients with traumatic brain<br />
injury. Crit Care Med. 30:733-738, 2002.<br />
28. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care.<br />
Management and Prognosis of Severe Traumatic<br />
Brain Injury. 2000<br />
http://www2.braintrauma.org/guidelines/downloads/bt<br />
f_guidelines_management.pdf [Evidenzbasierte<br />
Leitlinie]<br />
29. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care.<br />
Management and Prognosis of Severe Traumatic<br />
Brain Injury. Update 2003<br />
http://www2.braintrauma.org/guidelines/downloads/bt<br />
f_guidelines_cpp_u1.pdf.<br />
30. The Brain Trauma Foundation. The American<br />
Association of Neurological Surgeons. The Joint<br />
Section on Neurotrauma and Critical Care. Guidelines<br />
for the Management of Severe Traumatic Brain<br />
Injury. 3 rd Edition.<br />
http://braintrauma.org/guidelines/downloads/JON_24<br />
_Supp1.pdf [Evidenzbasierte Leitlinie]<br />
Emergency surgery phase – Traumatic brain injury 340
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.6 Genitourinary tract<br />
Key recommendations:<br />
Critical renal injuries (grade 5 according to the AAST classification) should<br />
be surgically explored.<br />
In the case of renal injuries < grade 5, a primary conservative procedure<br />
should be introduced in stable circulation conditions.<br />
If other injuries necessitate a laparotomy, renal injuries of average severity<br />
grade 3 or 4 can be surgically explored.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
GoR 0<br />
The indication to operate on renal injuries is now regarded with more restraint than a few years ago. In most<br />
cases, the decision to perform a laparotomy is already dictated by the intraabdominal concomitant injuries.<br />
However, life-threatening renal bleeding also represents an absolute indication for surgery [116]. The injury<br />
severity score according to AAST (American Association for the Surgery of Trauma) [117] has established<br />
itself as the basis of decision-making as this classification is closely correlated to the need for surgery and<br />
the possibility of salvaging the kidney [118]. Grade 5 renal injuries represent an indication for surgery<br />
because of the blood loss and/or threatening loss of renal function. In contrast, it is usually the case that<br />
grade 2 to grade 4 injuries can definitely be managed conservatively unless the patient has unstable<br />
circulation due to their renal injury; then the kidney should be surgically freed [119–133]. In the meantime,<br />
there are even individual reports by authors who have successfully treated grade 5 injuries conservatively<br />
[134, 135]. Provided pelvic or abdominal injuries require a laparotomy anyway, non-trivial renal injuries (><br />
grade 2) can be surgically explored as this increases therapeutic certainty and may even make second<br />
interventions superfluous.<br />
In particular, controversy has long surrounded the procedure for severe renal injuries with urine discharge<br />
and devitalized fragments. However, individual smaller studies have shown that even here non-surgical<br />
management is possible [136–138] even if the complication and revision rate here turns out to be markedly<br />
higher [139].<br />
Pathologic pyelogram findings with additional evidence of a pulsating or expanding retroperitoneal<br />
hematoma should be surgically explored in cases where only i.v. pyelography can be carried out because of<br />
prioritizing. The evidence of hematuria and ideally also the ultrasound finding should be used here in the<br />
evaluation. Ichigi et al. showed that the size of the perirenal hematoma is closely linked to the severity of the<br />
renal injury [140] so that this criterion can also be used in the decision between a surgical or conservative<br />
procedure [4, 6, 9].<br />
Emergency surgery phase – Genitourinary tract 341
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Table 25: Grading classification of renal trauma according to the American Association for the Surgery of<br />
Trauma (AAST) [117]<br />
Grade Properties<br />
1 Renal contusion, perirenal or subcapsular hematoma, no other lesion in the imaging<br />
2 Grade I lesion and laceration of the parenchyma up to 1 cm, collecting system not involved<br />
3 Laceration > 1 cm without urine extravasation<br />
4 Penetrating parenchymal lesion involving collecting system and/or hilar vessels<br />
5 Shattered kidney and/or renal vascular pedicle avulsion, bleeding/sequestration<br />
Key recommendation:<br />
Selective angiographic embolization of a renal artery injury can be attempted<br />
as a therapeutic option in the patient with stable circulation.<br />
Explanation:<br />
GoR 0<br />
Up till now, the importance of angiographic embolization has been documented in a few case series and case<br />
reports [95, 141, 142] but which also partly include non-traumatic bleeding of the renal arteries [143–145]).<br />
These studies also refer partly not only to the primary phase of polytrauma management but also describe<br />
the treatment of pseudoaneurysms or arteriovenous fistulas in the secondary phase [94, 146, 147]. According<br />
to these case series, bleeding is successfully arrested in about 82% [94] to 94% [95] of patients. In more<br />
recent review papers as well, the angiographic embolization of renal injuries in patients with stable<br />
circulation is increasingly accepted as the first intervention step albeit with reference to the monotrauma<br />
situation [9, 41, 47]. Usually, it involved branches of the renal artery which required embolization. It is<br />
undisputed that the selection of patients, the technical equipment, and the individual medical experience<br />
have a decisive influence on the success rate. Primarily because of the considerable amount of time required<br />
for embolization, selective angiographic embolization can only be successfully incorporated into the overall<br />
management in individual cases of multiply injured patients.<br />
Emergency surgery phase – Genitourinary tract 342
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendations:<br />
Depending on the type and severity of injury and concomitant injuries, a renal<br />
injury can be surgically managed by oversewing or, if necessary, by partial<br />
renal resection and other procedures to salvage the organ.<br />
GoR 0<br />
Primary nephrectomy should be reserved for grade 5 injuries. GoR B<br />
Explanation:<br />
In the multiply injured patient with renal injury, the surgical approach is usually determined by the overall<br />
injury pattern and then normally consists of a midline laparotomy. In order to control renal bleeding, the<br />
renal pedicle is generally prepared before opening Gerota’s fascia. Individual zig-zag sutures and continuous<br />
sutures are then used to arrest the bleeding [116]. Fibrin adhesives can be advantageous here [148]. The<br />
surgical procedure for the multiply injured patient is largely identical to that for the monotrauma patient and<br />
there is no need to go into detail here.<br />
The effort expended in reconstruction attempts should be based on the overall situation of the patient.<br />
Primary nephrectomy should be reserved for grade 5 injuries [9]. No long-term reconstruction attempts<br />
should be undertaken unless both kidneys are at risk. For reasons of time and the fewer complication<br />
possibilities, the indication for nephrectomy in the multiply injured patient should be made sooner than for<br />
the monotrauma patient [9, 41].<br />
Ureter injuries<br />
As ureter injuries are difficult to diagnose, if a laparotomy is being performed for another reason, it should<br />
be used for examining the ureters if such an injury is suspected [7]. Although macroscopic evaluation is also<br />
unreliable [102], it presents a huge advantage in that it allows a ureter injury to be treated early. Untreated<br />
ureter injuries lead to urine fistulas, urinomas, and infections so that the goal here should also be surgical<br />
management at the earliest opportunity [101]. The lesions are most frequently located in the proximal ureter<br />
[149]. A wide range of surgical procedures can be used [7].<br />
Emergency surgery phase – Genitourinary tract 343
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Bladder injuries<br />
Key recommendations:<br />
Intraperitoneal bladder ruptures should be surgically explored. GoR B<br />
Extraperitoneal bladder ruptures without involvement of the neck of the<br />
bladder can be conservatively treated through suprapubic urinary diversion.<br />
Explanation:<br />
GoR 0<br />
In most cases, the management of frequently numerous concomitant injuries should be given priority over a<br />
bladder injury. Numerically, extraperitoneal bladder ruptures are roughly twice common as intraperitoneal<br />
bladder ruptures [11, 60]. Combined extraperitoneal and intraperitoneal ruptures are markedly less<br />
frequently observed. Even taken on their own, intraperitoneal bladder ruptures represent a surgical<br />
indication since large tears are often found which can then lead to peritonitis and urinomas [150, 151]. The<br />
bladder should be closed and any urinomas drained.<br />
The majority of extraperitoneal bladder injuries can be treated conservatively by means of a catheter drain,<br />
even if large retroperitoneal or scrotal extravasates are present [150]. Based on a series of 30 extraperitoneal<br />
ruptures, Cass and Luxemberg report on a 93% success rate with this non-surgical method [152]. In another<br />
series of 41 patients, almost all extraperitoneal bladder ruptures healed successfully within 3 weeks [153].<br />
However, if the bladder neck is injured [11], bony fragments lie in the bladder or the bladder is clamped<br />
between bony pelvic fragments, a primary surgical procedure is necessary [1]. In the sequence of operations,<br />
osteosynthesis of the pelvis comes first followed by urological management [38]. Routt et al. also emphasize<br />
that good cooperation between the trauma surgeon and the urologist is essential here [38].<br />
Emergency surgery phase – Genitourinary tract 344
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Urethral injuries<br />
Key recommendation:<br />
Complete ruptures of the urethra should be treated in the emergency surgery<br />
phase by suprapubic urinary diversion.<br />
GoR B<br />
Urinary diversion can be supplemented by urethral re-alignment. GoR 0<br />
Provided a pelvic fracture or another intraabdominal injury necessitates<br />
surgery anyway, urethral ruptures should be managed in the same session.<br />
Explanation:<br />
GoR B<br />
It should be particularly mentioned in the management of urethral injuries that the method described here<br />
refers explicitly only to the emergency surgery phase as other principles also apply in the further<br />
management.<br />
To date, there has been insufficient evidence as to whether primary, delayed or secondary re-anastomosing<br />
should be preferred in complete ruptures of the posterior urethra. In addition, primary and delayed urethral<br />
re-alignment is proposed [8]. The main problems in the post-traumatic course are urethral strictures,<br />
incontinence, and impotence so the treatment goal is to avoid them.<br />
In a literature review summarizing several case series and comparative studies [20, 154–163] on the<br />
treatment of the urethral rupture, Koraitim [31, 164] describes the following rates of stricture, incontinence,<br />
and impotence: suprapubic diversion on its own 97%, 4% and 19%; primary re-alignment 53%, 5% and<br />
36%; primary suture 49%, 21% and 56%. Accordingly, in the case of a complete urethral rupture in the<br />
male, he recommends suprapubic diversion on its own or re-alignment if there is a large gap between the<br />
ends of the urethra. However, as this literature review spans back more than 50 years, more recent studies on<br />
urethral re-alignment with better results are perhaps not sufficiently taken into account. Nevertheless, even<br />
current studies find both treatment options of equal value [165]. Accordingly, the EAST Guideline also<br />
comes to the conclusion that both primary re-alignment and also suprapubic diversion with secondary<br />
surgery are equally worthy of recommendation [10].<br />
In the cases where surgery is necessary anyway due to other adjacent lesions, it appears expedient to manage<br />
the urethral rupture at the same time to avoid two-step management [166]. Particularly if the abdominal<br />
cavity is contaminated by large intestine injuries, primary suture of the urethra over a splinting catheter<br />
appears advisable to avoid complicating infections. Even if a conservative procedure actually appears to be<br />
possible, urethral injuries should be managed by primary surgery if the definitive osteosynthesis of the bony<br />
pelvis cannot otherwise be carried out [167].<br />
Ruptures of the anterior urethra in the male are somewhat rarer than those of the posterior urethra. Primary<br />
surgical reconstruction may be necessary in open injuries. In the majority of cases, however, preference<br />
should also be given here to suprapubic urinary diversion followed by later reconstruction as reconstruction<br />
of the anterior urethra and the external male genitals, which are often injured as well, is usually difficult and<br />
Emergency surgery phase – Genitourinary tract 345
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
time-consuming. However, in the case of a penile fracture with injury to the corpus spongiosum, it is<br />
recommended that the urethral injury also undergoes primary surgery [8, 168, 169]. The severity of the<br />
urological injury [170] and the overall severity of all injuries are crucial in deciding between primary<br />
surgery and conservative treatment.<br />
Urethral injuries occur markedly less frequently in women than in men. However, when they occur, they are<br />
mostly very pronounced and associated with bladder injuries. For this reason, primary treatment should<br />
consist only of suprapubic urinary diversion if the patient has unstable circulation and/or other injuries<br />
require more urgent surgical management [67]. On the other hand, in women with less severe polytrauma,<br />
ruptures in the proximal urethra can undergo primary reconstruction via retropubic approach [69, 70, 171].<br />
These recommendations apply similarly to children as well, whereby again a distinction should be made<br />
between the sexes. In a series of 35 boys with posterior urethra tears, Podestá et al. (1997) compared<br />
suprapubic diversion (with later urethroplasty), suprapubic diversion with urethral catheter alignment, and<br />
primary anastomosis [172]. As the continence rate after primary anastomosis only reached 50%, and in the<br />
group with catheter alignment all 10 patients still required urethroplasty later, the authors recommend<br />
suprapubic urinary diversion on its own followed by secondary urethroplasty. In a study on urethral injuries<br />
in girls with pelvic fracture and other concomitant injuries, the same authors found deferred management to<br />
be advantageous as good results could be observed despite vesical and vaginal concomitant injuries.<br />
Emergency surgery phase – Genitourinary tract 346
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Figure 5: Algorithm on the diagnostic and therapeutic procedure for suspected renal injuries<br />
Grade 5<br />
Gross or microscopic<br />
Grade 3-<br />
hematuria?<br />
Computer<br />
tomography<br />
yes<br />
no<br />
yes<br />
(or other procedures)<br />
Severity grade<br />
of renal trauma<br />
according to<br />
AAST?<br />
Laparotomy necessary for<br />
another reason?<br />
5<br />
8<br />
9<br />
4<br />
Suspected<br />
blunt renal trauma<br />
Circulatory shock due to<br />
abdominal bleeding?<br />
no<br />
Primary<br />
conservative<br />
treatment<br />
Surgical exploration<br />
of renal injury<br />
Emergency surgery phase – Genitourinary tract 347<br />
1<br />
6<br />
2<br />
10<br />
no<br />
yes<br />
Emergency laparotomy<br />
Pulsating<br />
retroperitoneal<br />
hematoma?<br />
yes<br />
3<br />
7
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1 Cass AS, Cass BP. Immediate surgical management<br />
of severe renal injuries in multiple-injured patients.<br />
Urology 1983: 21(2):140-145 [LoE 4].<br />
2 Zink RA, Muller-Mattheis V, Oberneder R. [Results<br />
of the West German multicenter study "Urological<br />
traumatology"]. Urologe A 1990: 29(5):243-250.<br />
3 Monstrey SJ, vander WC, Debruyne FM, Goris RJ.<br />
Urological trauma and severe associated injuries. Br J<br />
Urol 1987: 60(5):393-398.<br />
4 Lynch D, Martinez-Pineiro L, las E, erafetinides E,<br />
urkeri L, ohenfellner M. Guidelines on urological<br />
trauma. http://uroweb.org/files/uploaded<br />
files/guidelines/urotrauma.pdf: Ezropean Association<br />
of Urology , 1-70. 2003 [Evidenzbasierte Leitlinie]<br />
5 Lynch TH, Martinez-Pineiro L, Plas E, Serafetinides<br />
E, Turkeri L, Santucci RA et al. EAU guidelines on<br />
urological trauma. Eur Urol 2005: 47(1):1-15<br />
[Evidenzbasierte Leitlinie]<br />
6 Djakovic N, Plas E, Martinez-Pineiro L, Lynch TH,<br />
Mor Y, Santucci RA et al. Guidelines on urological<br />
trauma. http://uroweb.org/files/uploaded<br />
files/guidelines/urotrauma.pdf: Ezropean Associa-tion<br />
of Urology , 1-84. 2009 [Evidenzbasierte Leitlinie]<br />
7 Brandes S, Coburn M, Armenakas N, McAninch J.<br />
Diagnosis and management of ureteric injury: an<br />
evidence-based analysis. BJU Int 2004: 94(3):277-289<br />
[LoE 5].<br />
8 Chapple C, Barbagli G, Jordan G, Mundy AR,<br />
Rodrigues-Netto N, Pansadoro V et al. Consensus<br />
statement on urethral trauma. BJU Int 2004:<br />
93(9):1195-1202 [LoE 5].<br />
9 Santucci RA, Wessells H, Bartsch G, Descotes J,<br />
Heyns CF, McAninch JW et al. Evaluation and<br />
management of renal injuries: consensus statement of<br />
the renal trauma subcommittee. BJU Int 2004:<br />
93(7):937-954 [LoE 5].<br />
10 Holevar MEJLFNKSRSJPYC. Practice management<br />
guidelines for the management of genitourinary<br />
trauma. http://www.east.org/tpg.html: Eastern<br />
Association for the Surgery of Trauma (EAST) , 1-<br />
101. 2004 [Evidenzbasierte Leitlinie]<br />
11 Corriere JN, Jr., Sandler CM. Management of the<br />
ruptured bladder: seven years of experience with 111<br />
cases. J Trauma 1986: 26(9):830-833 [LoE 2].<br />
12 Glass RE, Flynn JT, King JB, Blandy JP. Urethral<br />
injury and fractured pelvis. Br J Urol 1978: 50(7):578-<br />
582.<br />
13 Morehouse DD, Mackinnon KJ. Posterior urethral<br />
injury: etiology, diagnosis, initial management. Urol<br />
Clin North Am 1977: 4(1):69-73.<br />
14 Nagel R, Leistenschneider W. [Urologic injuries in<br />
patients with multiple injuries]. Chirurg 1978:<br />
49(12):731-736.<br />
15 Medina D, Lavery R, Ross SE, Livingston DH.<br />
Ureteral trauma: preoperative studies neither predict<br />
injury nor prevent missed injuries. J Am Coll Surg<br />
1998: 186(6):641-644.<br />
Emergency surgery phase – Genitourinary tract<br />
16 Livingston DH, Lavery RF, Passannante MR,<br />
Skurnick JH, Fabian TC, Fry DE et al. Admission or<br />
observation is not necessary after a negative<br />
abdominal computed tomographic scan in patients<br />
with suspected blunt abdominal trauma: results of a<br />
prospective, multi-institutional trial. J Trauma 1998:<br />
44(2):273-280.<br />
17 Cotton BA, Beckert BW, Smith MK, Burd RS. The<br />
utility of clinical and laboratory data for predicting<br />
intraabdominal injury among children. J Trauma<br />
2004: 56(5):1068-1074.<br />
18 Allen GS, Moore FA, Cox CS, Jr., Wilson JT, Cohn<br />
JM, Duke JH. Hollow visceral injury and blunt<br />
trauma. J Trauma 1998: 45(1):69-75.<br />
9 Guldner G, Babbitt J, Boulton M, O'Callaghan T,<br />
Feleke R, Hargrove J. Deferral of the rectal<br />
examination in blunt trauma patients: a clinical<br />
decision rule. Acad Emerg Med 2004: 11(6):635-641.<br />
20 Porter JR, Takayama TK, Defalco AJ. Traumatic<br />
posterior urethral injury and early realignment using<br />
magnetic urethral catheters. J Urol 1997: 158(2):425-<br />
430 [LoE 4].<br />
21 Taylor GA, Eichelberger MR, O'Donnell R, Bowman<br />
L. Indications for computed tomography in children<br />
with blunt abdominal trauma. Ann Surg 1991:<br />
213(3):212-218.<br />
22 Holmes JF, Sokolove PE, Brant WE, Palchak MJ,<br />
Vance CW, Owings JT et al. Identification of children<br />
with intra-abdominal injuries after blunt trauma. Ann<br />
Emerg Med 2002: 39(5):500-509.<br />
23 Brosman SA, Paul JG. Trauma of the bladder. Surg<br />
Gynecol Obstet 1976: 143(4):605-608.<br />
24 Iverson AJ, Morey AF. Radiographic evaluation of<br />
suspected bladder rupture following blunt trauma:<br />
critical review. World J Surg 2001: 25(12):1588-1591.<br />
25 Demetriades D, Karaiskakis M, Toutouzas K, Alo K,<br />
Velmahos G, Chan L. Pelvic fractures: epidemiology<br />
and predictors of associated abdominal injuries and<br />
outcomes. J Am Coll Surg 2002: 195(1):1-10.<br />
26 Dokucu AI, Ozdemir E, Ozturk H, Otcu S, Onen A,<br />
Cigdem K et al. Urogenital injuries in childhood: a<br />
strong association of bladder trauma to bowel injuries.<br />
Int Urol Nephrol 2000: 32(1):3-8.<br />
27 Beck D, Marley R, Salvator A, Muakkassa F.<br />
Prospective study of the clinical predictors of a<br />
positive abdominal computed tomography in blunt<br />
trauma patients. J Trauma 2004: 57(2):296-300.<br />
28 Carter CT, Schafer N. Incidence of urethral disruption<br />
in females with traumatic pelvic fractures. Am J<br />
Emerg Med 1993: 11(3):218-220.<br />
29 Nicolaisen GS, McAninch JW, Marshall GA, Bluth<br />
RF, Jr., Carroll PR. Renal trauma: re-evaluation of the<br />
indications for radiographic assessment. J Urol 1985:<br />
133(2):183-187.<br />
30 Ingram MD, Watson SG, Skippage PL, Patel U.<br />
Urethral injuries after pelvic trauma: evaluation with<br />
urethrography. Radiographics 2008: 28(6):1631-1643.<br />
348
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
31 Koraitim MM. Pelvic fracture urethral injuries:<br />
evaluation of various methods of management. J Urol<br />
1996: 156(4):1288-1291 [LoE 2b].<br />
32 Chandhoke PS, McAninch JW. Detection and<br />
significance of microscopic hematuria in patients with<br />
blunt renal trauma. J Urol 1988: 140(1):16-18.<br />
33 Daum GS, Krolikowski FJ, Reuter KL, Colby JM,<br />
Silva WM. Dipstick evaluation of hematuria in<br />
abdominal trauma. Am J Clin Pathol 1988: 89(4):538-<br />
542.<br />
34 Goldner AP, Mayron R, Ruiz E. Are urine dipsticks<br />
reliable indicators of hematuria in blunt trauma<br />
patients? Ann Emerg Med 1985: 14(6):580-582.<br />
35 Kennedy TJ, McConnell JD, Thal ER. Urine dipstick<br />
vs. microscopic urinalysis in the evaluation of<br />
abdominal trauma. J Trauma 1988: 28(5):615-617.<br />
36 Mariani AJ, Luangphinith S, Loo S, Scottolini A,<br />
Hodges CV. Dipstick chemical urinalysis: an accurate<br />
cost-effective screening test. J Urol 1984: 132(1):64-<br />
66.<br />
37 Frohmüller H, Theiß M. Blutungen bei Verletzungen<br />
des Harntrakts. Langenbecks Arch Chir 1993:<br />
110(Suppl):352-357.<br />
38 Routt ML, Simonian PT, Defalco AJ, Miller J, Clarke<br />
T. Internal fixation in pelvic fractures and primary<br />
repairs of associated genitourinary disruptions: a team<br />
approach. J Trauma 1996: 40(5):784-790 [LoE 4].<br />
39 Zwergel T, op den WR, Zwergel U, Schwaiger R,<br />
Muhr G, Ziegler M. [Concept of interdisciplinary<br />
procedures within the scope of traumatology--the<br />
status of urology]. Unfallchirurgie 1983: 9(5):244-<br />
248.<br />
40 Peterson NE, Schulze KA. Selective diagnostic<br />
uroradiography for trauma. J Urol 1987: 137(3):449-<br />
451.<br />
41 Schmidlin F. [Renal trauma. Treatment strategies and<br />
indications for surgical exploration]. Urologe A 2005:<br />
44(8):863-869 [LoE 3].<br />
42 Pfitzenmaier J, Buse S, Haferkamp A, Pahernik S,<br />
Djakovic N, Hohenfellner M. [Kidney trauma].<br />
Urologe A 2008: 47(6):759-767.<br />
43 Fortune JB, Brahme J, Mulligan M, Wachtel TL.<br />
Emergency intravenous pyelography in the trauma<br />
patient. A reexamination of the indications. Arch Surg<br />
1985: 120(9):1056-1059.<br />
44 Klein S, Johs S, Fujitani R, State D. Hematuria<br />
following blunt abdominal trauma. The utility of<br />
intravenous pyelography. Arch Surg 1988:<br />
123(9):1173-1177.<br />
45 Levitt MA, Criss E, Kobernick M. Should the<br />
emergency IVP be used more selectively in blunt<br />
renal trauma? Ann Emerg Med 1985: 14(10):959-965.<br />
46 Thomason RB, Julian JS, Mostellar HC, Pennell TC,<br />
Meredith JW. Microscopic hematuria after blunt<br />
trauma. Is pyelography necessary? Am Surg 1989:<br />
55(3):145-150.<br />
47 Pfitzenmaier J, Buse S, Haferkamp A, Pahernik S,<br />
Hohenfellner M. Nierentrauma. Der Unfalllchirurg<br />
2009: 112:317-326 [LoE 3].<br />
48 Miller KS, McAninch JW. Radiographic assessment<br />
of renal trauma: our 15-year experience. J Urol 1995:<br />
154(2 Pt 1):352-355.<br />
49 McAndrew JD, Corriere JN, Jr. Radiographic<br />
evaluation of renal trauma: evaluation of 1103<br />
consecutive patients. Br J Urol 1994: 73(4):352-354.<br />
50 Fallon B, Wendt JC, Hawtrey CE. Urological injury<br />
and assessment in patients with fractured pelvis. J<br />
Urol 1984: 131(4):712-714.<br />
51 Mee SL, McAninch JW, Robinson AL, Auerbach PS,<br />
Carroll PR. Radiographic assessment of renal trauma:<br />
a 10-year prospective study of patient selection. J Urol<br />
1989: 141(5):1095-1098.<br />
52 Fuhrman GM, Simmons GT, Davidson BS, Buerk<br />
CA. The single indication for cystography in blunt<br />
trauma. Am Surg 1993: 59(6):335-337.<br />
53 Mayor B, Gudinchet F, Wicky S, Reinberg O,<br />
Schnyder P. Imaging evaluation of blunt renal trauma<br />
in children: diagnostic accuracy of intravenous<br />
pyelography and ultrasonography. Pediatr Radiol<br />
1995: 25(3):214-218.<br />
54 Middlebrook PF, Schillinger JF. Hematuria and<br />
intravenous pyelography in pediatric blunt renal<br />
trauma. Can J Surg 1993: 36(1):59-62.<br />
55 Perez-Brayfield MR, Gatti JM, Smith EA, Broecker<br />
B, Massad C, Scherz H et al. Blunt traumatic<br />
hematuria in children. Is a simplified algorithm<br />
justified? J Urol 2002: 167(6):2543-2546.<br />
56 Stein JP, Kaji DM, Eastham J, Freeman JA, Esrig D,<br />
Hardy BE. Blunt renal trauma in the pediatric<br />
population: indications for radiographic evaluation.<br />
Urology 1994: 44(3):406-410.<br />
57 Brandes SB, McAninch JW. Urban free falls and<br />
patterns of renal injury: a 20-year experience with 396<br />
cases. J Trauma 1999: 47(4):643-649.<br />
58 Carroll PR, McAninch JW. Major bladder trauma:<br />
mechanisms of injury and a unified method of<br />
diagnosis and repair. J Urol 1984: 132(2):254-257.<br />
59 Flancbaum L, Morgan AS, Fleisher M, Cox EF. Blunt<br />
bladder trauma: manifestation of severe injury.<br />
Urology 1988: 31(3):220-222.<br />
60 Hochberg E, Stone NN. Bladder rupture associated<br />
with pelvic fracture due to blunt trauma. Urology<br />
1993: 41(6):531-533 [LoE 2].<br />
61 Aihara R, Blansfield JS, Millham FH, LaMorte WW,<br />
Hirsch EF. Fracture locations influence the likelihood<br />
of rectal and lower urinary tract injuries in patients<br />
sustaining pelvic fractures. J Trauma 2002: 52(2):205-<br />
208.<br />
62 Batislam E, Ates Y, Germiyanoglu C, Karabulut A,<br />
Gulerkaya B, Erol D. Role of Tile classification in<br />
predicting urethral injuries in pediatric pelvic<br />
fractures. J Trauma 1997: 42(2):285-287.<br />
63 Knudson MM, McAninch JW, Gomez R, Lee P,<br />
Stubbs HA. Hematuria as a predictor of abdominal<br />
injury after blunt trauma. Am J Surg 1992:<br />
164(5):482-485.<br />
64 Koraitim MM, Marzouk ME, Atta MA, Orabi SS.<br />
Risk factors and mechanism of urethral injury in<br />
pelvic fractures. Br J Urol 1996: 77(6):876-880.<br />
Emergency surgery phase – Genitourinary tract 349
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
65 Morgan DE, Nallamala LK, Kenney PJ, Mayo MS,<br />
Rue LW, III. CT cystography: radiographic and<br />
clinical predictors of bladder rupture. AJR Am J<br />
Roentgenol 2000: 174(1):89-95.<br />
66 Palmer JK, Benson GS, Corriere JN, Jr. Diagnosis and<br />
initial management of urological injuries associated<br />
with 200 consecutive pelvic fractures. J Urol 1983:<br />
130(4):712-714.<br />
67 Venn SN, Greenwell TJ, Mundy AR. Pelvic fracture<br />
injuries of the female urethra. BJU Int 1999:<br />
83(6):626-630 [LoE 4].<br />
68 Ahmed S, Neel KF. Urethral injury in girls with<br />
fractured pelvis following blunt abdominal trauma. Br<br />
J Urol 1996: 78(3):450-453.<br />
69 Thambi Dorai CR, Boucaut HA, Dewan PA. Urethral<br />
injuries in girls with pelvic trauma. Eur Urol 1993:<br />
24(3):371-374 [LoE 4].<br />
70 Black PC, Miller EA, Porter JR, Wessells H. Urethral<br />
and bladder neck injury associated with pelvic<br />
fracture in 25 female patients. J Urol 2006:<br />
175(6):2140-2144 [LoE 4].<br />
71 Morey AF, Iverson AJ, Swan A, Harmon WJ, Spore<br />
SS, Bhayani S et al. Bladder rupture after blunt<br />
trauma: guidelines for diagnostic imaging. J Trauma<br />
2001: 51(4):683-686 [Evidenzbasierte Leitlinie]<br />
72 Rehm CG, Mure AJ, O'Malley KF, Ross SE. Blunt<br />
traumatic bladder rupture: the role of retrograde<br />
cystogram. Ann Emerg Med 1991: 20(8):845-847.<br />
73 Hsieh CH, Chen RJ, Fang JF, Lin BC, Hsu YP, Kao<br />
JL et al. Diagnosis and management of bladder injury<br />
by trauma surgeons. Am J Surg 2002: 184(2):143-<br />
147.<br />
74 Wolk DJ, Sandler CM, Corriere JN, Jr.<br />
Extraperitoneal bladder rupture without pelvic<br />
fracture. J Urol 1985: 134(6):1199-1201.<br />
75 Buchberger W, Penz T, Wicke K, Eberle J. [Diagnosis<br />
and staging of blunt kidney trauma. A comparison of<br />
urinalysis, i.v. urography, sonography and computed<br />
tomography]. Rofo 1993: 158(6):507-512.<br />
76 Cass AS, Vieira J. Comparison of IVP and CT<br />
findings in patients with suspected severe renal injury.<br />
Urology 1987: 29(5):484-487.<br />
77 Bretan PN, Jr., McAninch JW, Federle MP, Jeffrey<br />
RB, Jr. Computerized tomographic staging of renal<br />
trauma: 85 consecutive cases. J Urol 1986:<br />
136(3):561-565.<br />
78 Fanney DR, Casillas J, Murphy BJ. CT in the<br />
diagnosis of renal trauma. Radiographics 1990:<br />
10(1):29-40.<br />
79 Kinnunen J, Kivioja A, Poussa K, Laasonen EM.<br />
Emergency CT in blunt abdominal trauma of multiple<br />
injury patients. Acta Radiol 1994: 35(4):319-322.<br />
80 Becker CD, Mentha G, Schmidlin F, Terrier F. Blunt<br />
abdominal trauma in adults: role of CT in the<br />
diagnosis and management of visceral injuries. Part 2:<br />
Gastrointestinal tract and retroperitoneal organs. Eur<br />
Radiol 1998: 8(5):772-780.<br />
81 Rhea JT, Garza DH, Novelline RA. Controversies in<br />
emergency radiology. CT versus ultrasound in the<br />
evaluation of blunt abdominal trauma. Emerg Radiol<br />
2004: 10(6):289-295.<br />
82 Wah TM, Spencer JA. The role of CT in the<br />
management of adult urinary tract trauma. Clin Radiol<br />
2001: 56(4):268-277.<br />
83 Morey AF, McAninch JW, Tiller BK, Duckett CP,<br />
Carroll PR. Single shot intraoperative excretory<br />
urography for the immediate evaluation of renal<br />
trauma. J Urol 1999: 161(4):1088-1092.<br />
84 Halsell RD, Vines FS, Shatney CH, Slepin MJ,<br />
Northup HM, Avara WT, III et al. The reliability of<br />
excretory urography as a screening examination for<br />
blunt renal trauma. Ann Emerg Med 1987:<br />
16(11):1236-1239.<br />
85 Poletti PA, Kinkel K, Vermeulen B, Irmay F, Unger<br />
PF, Terrier F. Blunt abdominal trauma: should US be<br />
used to detect both free fluid and organ injuries?<br />
Radiology 2003: 227(1):95-103.<br />
86 Yoshii H, Sato M, Yamamoto S, Motegi M, Okusawa<br />
S, Kitano M et al. Usefulness and limitations of<br />
ultrasonography in the initial evaluation of blunt<br />
abdominal trauma. J Trauma 1998: 45(1):45-50.<br />
87 St<strong>eng</strong>el D, Bauwens K, Porzsolt F, Rademacher G,<br />
Mutze S, Ekkernkamp A. [Emergency ultrasound for<br />
blunt abdominal trauma--meta-analysis update 2003].<br />
Zentralbl Chir 2003: 128(12):1027-1037.<br />
88 St<strong>eng</strong>el D, Bauwens K, Sehouli J, Porzsolt F,<br />
Rademacher G, Mutze S et al. Systematic review and<br />
meta-analysis of emergency ultrasonography for blunt<br />
abdominal trauma. Br J Surg 2001: 88(7):901-912.<br />
89 Rose JS, Levitt MA, Porter J, Hutson A, Greenholtz J,<br />
Nobay F et al. Does the presence of ultrasound really<br />
affect computed tomographic scan use? A prospective<br />
randomized trial of ultrasound in trauma. J Trauma<br />
2001: 51(3):545-550.<br />
90 Lupetin AR, Mainwaring BL, Daffner RH. CT<br />
diagnosis of renal artery injury caused by blunt<br />
abdominal trauma. AJR Am J Roentgenol 1989:<br />
153(5):1065-1068.<br />
91 Corr P, Hacking G. Embolization in traumatic<br />
intrarenal vascular injuries. Clin Radiol 1991:<br />
43(4):262-264.<br />
92 Eastham JA, Wilson TG, Larsen DW, Ahlering TE.<br />
Angiographic embolization of renal stab wounds. J<br />
Urol 1992: 148(2 Pt 1):268-270.<br />
93 Hagiwara A, Murata A, Matsuda T, Matsuda H,<br />
Shimazaki S. The usefulness of transcatheter arterial<br />
embolization for patients with blunt polytrauma<br />
showing transient response to fluid resuscitation. J<br />
Trauma 2004: 57(2):271-276.<br />
94 Heyns CF, van VP. Increasing role of angiography<br />
and segmental artery embolization in the management<br />
of renal stab wounds. J Urol 1992: 147(5):1231-1234<br />
[LoE 4].<br />
95 Uflacker R, Paolini RM, Lima S. Management of<br />
traumatic hematuria by selective renal artery<br />
embolization. J Urol 1984: 132(4):662-667 [LoE 4].<br />
96 Leppaniemi A, Lamminen A, Tervahartiala P,<br />
Haapiainen R, Lehtonen T. Comparison of high-field<br />
magnetic resonance imaging with computed<br />
tomography in the evaluation of blunt renal trauma. J<br />
Trauma 1995: 38(3):420-427 [LoE 4].<br />
Emergency surgery phase – Genitourinary tract 350
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
97 Leppaniemi A, Lamminen A, Tervahartiala P, Salo J,<br />
Haapiainen R, Lehtonen T. MRI and CT in blunt renal<br />
trauma: an update. Semin Ultrasound CT MR 1997:<br />
18(2):129-135.<br />
98 Leppaniemi AK, Kivisaari AO, Haapiainen RK,<br />
Lehtonen TA. Role of magnetic resonance imaging in<br />
blunt renal parenchymal trauma. Br J Urol 1991:<br />
68(4):355-360.<br />
99 Ku JH, Jeon YS, Kim ME, Lee NK, Park YH. Is there<br />
a role for magnetic resonance imaging in renal<br />
trauma? Int J Urol 2001: 8(6):261-267.<br />
100 Ambiavagar R, Nambiar R. Traumatic closed avulsion<br />
of the upper ureter. Injury 1979: 11(1):71-76.<br />
101 Armenakas NA. Current methods of diagnosis and<br />
management of ureteral injuries. World J Urol 1999:<br />
17(2):78-83 [LoE 4].<br />
102 Ghali AM, El Malik EM, Ibrahim AI, Ismail G,<br />
Rashid M. Ureteric injuries: diagnosis, management,<br />
and outcome. J Trauma 1999: 46(1):150-158 [LoE 4].<br />
103 Dobrowolski Z, Kusionowicz J, Drewniak T, Habrat<br />
W, Lipczynski W, Jakubik P et al. Renal and ureteric<br />
trauma: diagnosis and management in Poland. BJU Int<br />
2002: 89(7):748-751.<br />
104 Sandler CM, Goldman SM, Kawashima A. Lower<br />
urinary tract trauma. World J Urol 1998: 16(1):69-75.<br />
105 Carroll PR, McAninch JW. Major bladder trauma: the<br />
accuracy of cystography. J Urol 1983: 130(5):887-<br />
888.<br />
106 Festini G, Gregorutti S, Reina G, Bellis GB. Isolated<br />
intraperitoneal bladder rupture in patients with alcohol<br />
intoxication and minor abdominal trauma. Ann Emerg<br />
Med 1991: 20(12):1371-1372.<br />
107 MacMahon R, Hosking D, Ramsey EW. Management<br />
of blunt injury to the lower urinary tract. Can J Surg<br />
1983: 26(5):415-418.<br />
108 Werkman HA, Jansen C, Klein JP, Ten Duis HJ.<br />
Urinary tract injuries in multiply-injured patients: a<br />
rational guideline for the initial assessment. Injury<br />
1991: 22(6):471-474 [Evidenzbasierte Leitlinie]<br />
109 Vaccaro JP, Brody JM. CT cystography in the<br />
evaluation of major bladder trauma. Radiographics<br />
2000: 20(5):1373-1381.<br />
110 Pao DM, Ellis JH, Cohan RH, Korobkin M. Utility of<br />
routine trauma CT in the detection of bladder rupture.<br />
Acad Radiol 2000: 7(5):317-324.<br />
111 Deck AJ, Shaves S, Talner L, Porter JR.<br />
Computerized tomography cystography for the<br />
diagnosis of traumatic bladder rupture. J Urol 2000:<br />
164(1):43-46.<br />
112 Deck AJ, Shaves S, Talner L, Porter JR. Current<br />
experience with computed tomographic cystography<br />
and blunt trauma. World J Surg 2001: 25(12):1592-<br />
1596.<br />
113 P<strong>eng</strong> MY, Parisky YR, Cornwell EE, III, Radin R,<br />
Bragin S. CT cystography versus conventional<br />
cystography in evaluation of bladder injury. AJR Am<br />
J Roentgenol 1999: 173(5):1269-1272.<br />
114 Horstman WG, McClennan BL, Heiken JP.<br />
Comparison of computed tomography and<br />
conventional cystography for detection of traumatic<br />
bladder rupture. Urol Radiol 1991: 12(4):188-193.<br />
115 Lis LE, Cohen AJ. CT cystography in the evaluation<br />
of bladder trauma. J Comput Assist Tomogr 1990:<br />
14(3):386-389.<br />
116 Brandes SB, McAninch JW. Reconstructive surgery<br />
for trauma of the upper urinary tract. Urol Clin North<br />
Am 1999: 26(1):183-99, [LoE 5].<br />
117 Moore EE, Shackford SR, Pachter HL, McAninch<br />
JW, Browner BD, Champion HR et al. Organ injury<br />
scaling: spleen, liver, and kidney. J Trauma 1989:<br />
29(12):1664-1666.<br />
118 Santucci RA, McAninch JW, Safir M, Mario LA,<br />
Service S, Segal MR. Validation of the American<br />
Association for the Surgery of Trauma organ injury<br />
severity scale for the kidney. J Trauma 2001:<br />
50(2):195-200 [LoE 4].<br />
119 Wessells H, McAninch JW, Meyer A, Bruce J.<br />
Criteria for nonoperative treatment of significant<br />
penetrating renal lacerations. J Urol 1997: 157(1):24-<br />
27 [LoE 2].<br />
120 Buckley JC, McAninch JW. Selective management of<br />
isolated and nonisolated grade IV renal injuries. J<br />
Urol 2006: 176(6 Pt 1):2498-2502 [LoE 4].<br />
121 Baverstock R, Simons R, McLoughlin M. Severe<br />
blunt renal trauma: a 7-year retrospective review from<br />
a provincial trauma centre. Can J Urol 2001:<br />
8(5):1372-1376 [LoE 4].<br />
122 Ch<strong>eng</strong> DL, Lazan D, Stone N. Conservative treatment<br />
of type III renal trauma. J Trauma 1994: 36(4):491-<br />
494 [LoE 4].<br />
123 Smith EM, Elder JS, Spirnak JP. Major blunt renal<br />
trauma in the pediatric population: is a nonoperative<br />
approach indicated? J Urol 1993: 149(3):546-548<br />
[LoE 4].<br />
124 El-Sherbiny MT, Aboul-Ghar ME, Hafez AT,<br />
Hammad AA, Bazeed MA. Late renal functional and<br />
morphological evaluation after non-operative<br />
treatment of high-grade renal injuries in children. BJU<br />
Int 2004: 93(7):1053-1056 [LoE 4].<br />
125 Hammer CC, Santucci RA. Effect of an institutional<br />
policy of nonoperative treatment of grades I to IV<br />
renal injuries. J Urol 2003: 169(5):1751-1753 [LoE<br />
4].<br />
126 Keller M. Functional outcome of nonoperatively<br />
managed renal injuries in children. J Trauma 2004:<br />
57:108-110 [LoE 4].<br />
127 Levy JB, Baskin LS, Ewalt DH, Zderic SA, Bellah R,<br />
Snyder HM, III et al. Nonoperative management of<br />
blunt pediatric major renal trauma. Urology 1993:<br />
42(4):418-424 [LoE 4].<br />
128 Moudouni SM, Hadj SM, Manunta A, Patard JJ,<br />
Guiraud PH, Guille F et al. Management of major<br />
blunt renal lacerations: is a nonoperative approach<br />
indicated? Eur Urol 2001: 40(4):409-414 [LoE 4].<br />
129 Robert M, Drianno N, Muir G, Delbos O, Guiter J.<br />
Management of major blunt renal lacerations: surgical<br />
or nonoperative approach? Eur Urol 1996: 30(3):335-<br />
339 [LoE 4].<br />
130 Russell RS, Gomelsky A, McMahon DR, Andrews D,<br />
Nasrallah PF. Management of grade IV renal injury in<br />
children. J Urol 2001: 166(3):1049-1050 [LoE 4].<br />
Emergency surgery phase – Genitourinary tract 351
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
131 Santucci RA, McAninch JM. Grade IV renal injuries:<br />
evaluation, treatment, and outcome. World J Surg<br />
2001: 25(12):1565-1572 [LoE 4].<br />
132 Thall EH, Stone NN, Ch<strong>eng</strong> DL, Cohen EL, Fine EM,<br />
Leventhal I et al. Conservative management of<br />
penetrating and blunt Type III renal injuries. Br J Urol<br />
1996: 77(4):512-517 [LoE 4].<br />
133 Toutouzas KG, Karaiskakis M, Kaminski A,<br />
Velmahos GC. Nonoperative management of blunt<br />
renal trauma: a prospective study. Am Surg 2002:<br />
68(12):1097-1103 [LoE 4].<br />
134 Bozeman C, Carver B, Zabari G, Caldito G, Venable<br />
D. Selective operative management of major blunt<br />
renal trauma. J Trauma 2004: 57(2):305-309 [LoE 2].<br />
135 Altman AL, Haas C, Dinchman KH, Spirnak JP.<br />
Selective nonoperative management of blunt grade 5<br />
renal injury. J Urol 2000: 164(1):27-30 [LoE 4].<br />
136 Husmann DA, Gilling PJ, Perry MO, Morris JS,<br />
Boone TB. Major renal lacerations with a devitalized<br />
fragment following blunt abdominal trauma: a<br />
comparison between nonoperative (expectant) versus<br />
surgical management. J Urol 1993: 150(6):1774-1777<br />
[LoE 2b].<br />
137 Matthews LA, Smith EM, Spirnak JP. Nonoperative<br />
treatment of major blunt renal lacerations with urinary<br />
extravasation. J Urol 1997: 157(6):2056-2058 [LoE<br />
4].<br />
138 Moudouni SM, Patard JJ, Manunta A, Guiraud P,<br />
Guille F, Lobel B. A conservative approach to major<br />
blunt renal lacerations with urinary extravasation and<br />
devitalized renal segments. BJU Int 2001: 87(4):290-<br />
294 [LoE 4].<br />
139 Husmann DA, Morris JS. Attempted nonoperative<br />
management of blunt renal lacerations extending<br />
through the corticomedullary junction: the short-term<br />
and long-term sequelae. J Urol 1990: 143(4):682-684<br />
[LoE 4].<br />
140 Ichigi Y, Takaki N, Nakamura K, Sato S, Kato A,<br />
Matsuo Y et al. Significance of hematoma size for<br />
evaluating the grade of blunt renal trauma. Int J Urol<br />
1999: 6(10):502-508 [LoE 2].<br />
141 Goldin AR, Funston MR. Percutaneous embolization<br />
for post-traumatic renal haemorrhage. S Afr Med J<br />
1978: 53(26):1061-1063 [LoE 4].<br />
142 Richman SD, Green WM, Kroll R, Casarella WJ.<br />
Superselective transcatheter embolization of traumatic<br />
renal hemorrhage. AJR Am J Roentgenol 1977:<br />
128(5):843-846 [LoE 4].<br />
143 Beaujeux R, Saussine C, al-Fakir A, Boudjema K,<br />
Roy C, Jacqmin D et al. Superselective endo-vascular<br />
treatment of renal vascular lesions. J Urol 1995:<br />
153(1):14-17 [LoE 4].<br />
144 Chatziioannou A, Brountzos E, Primetis E, Malagari<br />
K, Sofocleous C, Mourikis D et al. Effects of<br />
superselective embolization for renal vascular injuries<br />
on renal parenchyma and function. Eur J Vasc<br />
Endovasc Surg 2004: 28(2):201-206 [LoE 4].<br />
145 Fisher RG, Ben-Menachem Y, Whigham C. Stab<br />
wounds of the renal artery branches: angiographic<br />
diagnosis and treatment by embolization. AJR Am J<br />
Roentgenol 1989: 152(6):1231-1235 [LoE 4].<br />
146 Dinkel HP, Danuser H, Triller J. Blunt renal trauma:<br />
minimally invasive management with microcatheter<br />
embolization experience in nine patients. Radiology<br />
2002: 223(3):723-730 [LoE 4].<br />
147 Miller DC, Forauer A, Faerber GJ. Successful<br />
angioembolization of renal artery pseudoaneurysms<br />
after blunt abdominal trauma. Urology 2002:<br />
59(3):444 [LoE 4].<br />
148 Shekarriz B, Stoller ML. The use of fibrin sealant in<br />
urology. J Urol 2002: 167(3):1218-1225 [LoE 4].<br />
149 Elliott SP, McAninch JW. Ureteral injuries from<br />
external violence: the 25-year experience at San<br />
Francisco General Hospital. J Urol 2003: 170(4 Pt<br />
1):1213-1216 [LoE 4].<br />
150 Morey AF, Hernandez J, McAninch JW.<br />
Reconstructive surgery for trauma of the lower<br />
urinary tract. Urol Clin North Am 1999: 26(1):49-60,<br />
viii [LoE 5].<br />
151 Thomae KR, Kilambi NK, Poole GV. Method of<br />
urinary diversion in nonurethral traumatic bladder<br />
injuries: retrospective analysis of 70 cases. Am Surg<br />
1998: 64(1):77-80 [LoE 4].<br />
152 Cass AS, Luxenberg M. Features of 164 bladder<br />
ruptures. J Urol 1987: 138(4):743-745 [LoE 4].<br />
153 Corriere JN, Jr., Sandler CM. Management of<br />
extraperitoneal bladder rupture. Urol Clin North Am<br />
1989: 16(2):275-277 [LoE 4].<br />
154 Asci R, Sarikaya S, Buyukalpelli R, Saylik A, Yilmaz<br />
AF, Yildiz S. Voiding and sexual dysfunctions after<br />
pelvic fracture urethral injuries treated with either<br />
initial cystostomy and delayed urethroplasty or<br />
immediate primary urethral realignment. Scand J Urol<br />
Nephrol 1999: 33(4):228-233 [LoE 2b].<br />
155 Elliott DS, Barrett DM. Long-term followup and<br />
evaluation of primary realignment of posterior<br />
urethral disruptions. J Urol 1997: 157(3):814-816<br />
[LoE 2b].<br />
156 Follis HW, Koch MO, McDougal WS. Immediate<br />
management of prostatomembranous urethral<br />
disruptions. J Urol 1992: 147(5):1259-1262 [LoE 2b].<br />
157 Herschorn S, Thijssen A, Radomski SB. The value of<br />
immediate or early catheterization of the traumatized<br />
posterior urethra. J Urol 1992: 148(5):1428-1431<br />
[LoE 2b].<br />
158 Husmann DA, Wilson WT, Boone TB, Allen TD.<br />
Prostatomembranous urethral disruptions:<br />
management by suprapubic cystostomy and delayed<br />
urethroplasty. J Urol 1990: 144(1):76-78 [LoE 2b].<br />
159 Kotkin L, Koch MO. Impotence and incontinence<br />
after immediate realignment of posterior urethral<br />
trauma: result of injury or management? J Urol 1996:<br />
155(5):1600-1603 [LoE 2b].<br />
160 Gheiler EL, Frontera JR. Immediate primary<br />
realignment of prostatomembranous urethral<br />
disruptions using endourologic techniques. Urology<br />
1997: 49(4):596-599 [LoE 4].<br />
161 Singh PB, Karmakar D, Gupta RC, Dwivedi US,<br />
Tripathi VN. Result of suprapubic cystostomy only as<br />
primary management of posterior urethral rupture<br />
following pelvic fracture. Int Surg 1988: 73(1):59-62<br />
[LoE 4].<br />
Emergency surgery phase – Genitourinary tract 352
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
162 Mouraviev VB, Coburn M, Santucci RA. The<br />
treatment of posterior urethral disruption associated<br />
with pelvic fractures: comparative experience of early<br />
realignment versus delayed urethroplasty. J Urol<br />
2005: 173(3):873-876 [LoE 4].<br />
163 Culty T, Boccon-Gibod L. Anastomotic urethroplasty<br />
for posttraumatic urethral stricture: previous urethral<br />
manipulation has a negative impact on the <strong>final</strong><br />
outcome. J Urol 2007: 177(4):1374-1377 [LoE 4].<br />
164 Koraitim MM. Pelvic fracture urethral injuries: the<br />
unresolved controversy. J Urol 1999: 161(5):1433-<br />
1441 [LoE 2b].<br />
165 Ku JH, Jeon YS, Kim ME, Lee NK, Park YH.<br />
Comparison of long-term results according to the<br />
primary mode of management and type of injury for<br />
posterior urethral injuries. Urol Int 2002: 69(3):227-<br />
232 [LoE 2b].<br />
166 Brandes S, Borrelli J, Jr. Pelvic fracture and<br />
associated urologic injuries. World J Surg 2001:<br />
25(12):1578-1587 [LoE 5].<br />
167 Mayher BE, Guyton JL, Gingrich JR. Impact of<br />
urethral injury management on the treatment and<br />
outcome of concurrent pelvic fractures. Urology 2001:<br />
57(3):439-442 [LoE 4].<br />
168 Anselmo G, Fandella A, Faggiano L, Merlo F,<br />
Maccatrozzo L. Fractures of the penis: therapeutic<br />
approach and long-term results. Br J Urol 1991:<br />
67(5):509-511 [LoE 4].<br />
169 Nane I, Esen T, Tellaloglu S, Selhanoglu M, Akinci<br />
M. Penile fracture: emergency surgery for<br />
preservation of penile functions. Andrologia 1991:<br />
23(4):309-311 [LoE 4].<br />
170 Mohr AM, Pham AM, Lavery RF, Sifri Z, Bargman<br />
V, Livingston DH. Management of trauma to the male<br />
external genitalia: the usefulness of American<br />
Association for the Surgery of Trauma organ injury<br />
scales. J Urol 2003: 170(6 Pt 1):2311-2315 [LoE 4].<br />
171 Netto Junior NR, Ikari O, Zuppo VP. Traumatic<br />
rupture of female urethra. Urology 1983: 22(6):601-<br />
603 [LoE 4].<br />
172 Podesta ML, Medel R, Castera R, Ruarte A.<br />
Immediate management of posterior urethral<br />
disruptions due to pelvic fracture: therapeutic<br />
alternatives. J Urol 1997: 157(4):1444-1448 [LoE 2b]<br />
Emergency surgery phase – Genitourinary tract 353
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.7 Spine<br />
Indication for surgery<br />
Key recommendation:<br />
Unstable spinal injuries with confirmed or assumed neurologic deficits, with<br />
malpositions in which neurologic deficits can probably be prevented or<br />
improved by reduction, decompression, and stabilization, should be operated<br />
on as early as possible (“day 1 surgery”).<br />
Explanation:<br />
GoR B<br />
After life-threatening injuries to the body cavities and the head, and the long bones, spinal<br />
injuries occupy third place, or second place if there is a spinal cord injury, in management<br />
priority [1].<br />
Surgical indications are atlanto-occipital dislocation, translatory atlanto-axial dislocation,<br />
unstable Jefferson fracture, unstable Dens fracture (particularly type II), Hangman fracture (rib<br />
fracture C2 and invertebral disc injury C2/C3), C3 to C7 fractures (A3, B and C types) also in<br />
terms of dislocation, and T1 to L5 fractures (A3, B and C types) also in terms of dislocation.<br />
According to prevailing opinion, an absolute primary surgical indication exists even if there is an<br />
open spinal injury [2, 3].<br />
In addition, the indication for primary management of a spinal injury in polytrauma is assisted by<br />
the classification according to Blauth et al. (1998) into a) complex spinal injuries with an injury<br />
to essential neural pathways and organs such as the spinal cord, lung, great vessels and<br />
abdominal organs, b) unstable spinal injuries (type A3, B and C - in this case, functional<br />
treatment can lead to severe malpositions and neurologic damage), and c) stable spinal injuries.<br />
If a complex spinal injury or an unstable spinal injury is involved, the goal should be surgical<br />
stabilization at the earliest possible opportunity - in other words, on the day of the accident if<br />
none of the contraindications mentioned below are present [4].<br />
According to Blauth et al. (1998), a complex spinal injury is a multi-level spinal injury or one<br />
accompanied by intrathoracic or intraabdominal injury or polytrauma. The fact that polytrauma<br />
makes a spinal injury a “complex” injury is substantiated inter alia by studies by Hebert and<br />
Burnham [5] which established that the l<strong>eng</strong>th of stay in hospital was extended and the number<br />
of surgical interventions increased in these patients and that the combination of spinal<br />
injury/polytrauma is associated with an increased morbidity and mortality and an increased<br />
degree of disability. Nevertheless, according to a survey in North America by Tator et al. (1999),<br />
1/3 of spinal injuries with neurologic injuries were still conservatively treated and of those<br />
operated on only 60% received surgery before the 5th day and 40% after [6].<br />
The goal of primary surgical management in unstable spinal injuries with confirmed or assumed<br />
neurologic deficits or with malpositions is firstly early spinal decompression and the avoidance<br />
Emergency surgery phase – Spine 354
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
of neurologic secondary damage and secondly to achieve positioning stability for the intensive<br />
treatment [1].<br />
The indication for surgery to avoid neurologic damage is relatively clear in unstable fractures<br />
without spinal cord lesion. If there are spinal injuries which are unstable and which could be<br />
displaced by necessary positioning measures such as in chest trauma, the indication for primary<br />
spinal stabilization should be made [4, 7-9]. However, controversy surrounds the issue of<br />
whether early or later fracture management is advantageous in fractures where spinal cord injury<br />
has already occurred. As far as neurologic symptoms are concerned, animal experiments show<br />
advantages in spinal stabilization being carried out as early as possible [10, 11]. However, in the<br />
field of clinical research, several large systematic reviews (some with meta-analysis) could<br />
detect no clear correlation between the timing of surgery and the neurologic outcome [12-15].<br />
Only the most recent meta-analysis by La Rosa et al. [12] revealed that early surgical<br />
decompression has advantages compared to late decompression or conservative treatment. In the<br />
early group (17 studies), an improvement in neurology could be found in 42% of patients with<br />
complete deficit, and in 90% with incomplete deficit. In the late group, the improvement quotas<br />
were 8% and 59%, in the conservative group 25% and 59%. However, as the results from the<br />
studies differ greatly, La Rosa et al. also describe early surgery only as a “practical option”.<br />
The only randomized controlled trial on this was conducted on 62 patients with cervical spinal<br />
injury only [16]. Although the authors found no difference between early (< 72 hours) versus late<br />
stabilization (> 5 days) in the neurologic outcome, they still recommended early stabilization.<br />
Levi et al. also found indifferent results concerning the early (< 24 hours) and late (> 24 hours)<br />
stabilization in the cervical spine injury but ultimately also recommend early surgery [17]. After<br />
Wagner and Chehrazi also found no correlation between the timing of surgery and neurologic<br />
outcome in cervical spine injuries, they concluded [18] that primary medullary damage<br />
determines the prognosis. McKinley et al. draw a similar conclusion [19]. In contrast,<br />
Papadopoulos et al. observed improved neurologic outcomes after early surgery [20]. Mirz et al.<br />
also described in 1999 [21] that early stabilization (< 72 hours) of a cervical spine injury is more<br />
favorable for the neurologic outcome than later stabilization (> 72 hours). However, all these are<br />
data from studies that did not study exclusively multiply injured patients.<br />
In addition to these studies focusing primarily on the neurologic outcome, there is a series of<br />
studies which have concentrated mainly on the non-neurologic effects of early stabilization. A<br />
study by Croce et al. found evidence in 2001 [7] that, in contrast to late stabilization (> 3 days<br />
after trauma), early stabilization (< 3 days after trauma) of the spinal injury offers advantages,<br />
especially in polytrauma (mean ISS 24) with thoracic spine injury, as the intensive care period,<br />
pneumonia rate, costs, and ventilation time can be reduced. The studies by Johnson et al. [8] also<br />
argue in favor of primary stabilization of unstable spinal fractures as this can lower the ARDS<br />
rate especially in multiply injured patients. Dai et al. also observed a reduction in pulmonary<br />
complications after early management [22]. According to results by Aebi et al. [23], the<br />
immediate surgical management of a cervical spine injury is more important for neurologic<br />
outcome than improved surgical techniques. In a study published in 2005, Kerwin et al. [24]<br />
Emergency surgery phase – Spine 355
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
found that primary stabilization of the spine in critically injured patients (ISS > 25) shortened the<br />
l<strong>eng</strong>th of hospital stay from 29 to 20 days.<br />
The above-mentioned indications presume that a diagnostic study which adequately balances the<br />
injury could be performed in the emergency room phase. The patient should have stable<br />
cardiopulmonary parameters, and surgical bleeding sources should be excluded. Additional vital<br />
parameters such as intracranial pressure, core body temperature, and coagulatory function should<br />
lie within the normal range. If there is a substantiated risk that the condition of the casualty will<br />
worsen in a significantly (life-) threatening way by primary reduction, decompression, and<br />
stabilization of the spine, then spine stabilization is relatively contraindicated.<br />
If the patient has stable intracranial pressure, pulmonary, cardiac, and circulatory function, this<br />
multiply injured patient benefits especially from early management of the spinal injury:<br />
positioning stability is achieved, thereby avoiding second hits through subsequent surgery and<br />
also reducing the antigenic load through the instability of a fracture in proximity to the trunk. On<br />
the other hand, critical conditions with hypothermia, massive transfusion, coagulation<br />
derangement, lung failure, and high catecholamine dependency constitute relative<br />
contraindications for immediate spine stabilization.<br />
In this context, McLain and Benson (1999) [25] ascertained that immediate (< 24 hours after<br />
trauma) stabilization had the same outcomes as early stabilization (24-72 hours after trauma) of<br />
an unstable spinal fracture if the patients had multiple injuries, neurologic symptoms, and a<br />
concomitant thoracic-abdominal injury. Nevertheless, the authors recommend that stabilization is<br />
carried out as early as possible. Schlegel et al. [26] and Chipman et al. [27] also ascertained that<br />
surgical stabilization of unstable spinal fractures within 72 hours especially in polytrauma was<br />
associated with lower morbidity (fewer lung complications, fewer urinary tract infections,<br />
shorter hospitalization and intensive care stay). If there is an abdominal injury, which leads to<br />
laparotomy in up to 38% of patients with a spinal fracture [28], it must be weighed up after<br />
surgical management of the abdomen whether the unstable spinal fracture must or can be<br />
stabilized during the same session.<br />
In contrast, in the case of a hemothorax, the condition of bleeding in the ribcage alone supports<br />
early stabilization of a thoracic spine injury [29]. The results from the study by Petitjean et al.<br />
[30] also argue in favor of early stabilization of the thoracic spine fracture inter alia secondary to<br />
simultaneous chest trauma with pulmonary contusion. If there is a primary transverse lesion or<br />
irreducible dislocation, surgery can be postponed until organ functions are stabilized during<br />
intensive care treatment.<br />
In conclusion, therefore, there is an advantage in early surgery for the multiply injured patient<br />
particularly against the background of the publications in recent years between 2006 and 2008<br />
[31–45] Although the neurologic outcomes appear relatively unaffected by the timing of surgery,<br />
early fracture stabilization helps to minimize general complications and the l<strong>eng</strong>th of hospital<br />
stay. As general complications, particularly lung-related, are common in the multiply injured<br />
patient, the result is the above recommendation for surgery at the earliest possible opportunity.<br />
Key recommendations:<br />
Emergency surgery phase – Spine 356
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Unstable thoracolumbar spine injuries without neurologic deficit should be<br />
surgically managed.<br />
Surgery should be performed on the day of the accident or alternatively later<br />
during the course.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
Apart from the B and C injuries, this applies particularly to A2 and A3 fractures of the<br />
thoracolumbar spine which are not displaced by positioning measures during intensive care.<br />
There is no reason here for urgently stabilizing such an injury on the day of the accident.<br />
However, according to results from Jacobs et al. [46], it generally applies that the successes of<br />
surgical treatment on unstable thoracic and lumbar spine fractures are better than those of<br />
conservative treatment in respect of reduction, neurology, mobilization, rehabilitation period,<br />
and incidence of complications [47].<br />
Key recommendation:<br />
Stable spinal injuries without neurologic deficit should be treated<br />
conservatively.<br />
Explanation:<br />
GoR B<br />
The fracture type A1, if applicable also A2, which does not benefit from surgical stabilization, is<br />
regarded as stable [48, 49], particularly if the adjacent vertebral discs remain intact. Surgical<br />
stabilization is not indicated in polytrauma [50].<br />
Emergency surgery phase – Spine 357
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Surgery technique<br />
Key recommendation:<br />
For injuries to the cervical spine, primary surgical methods that can be used<br />
are: 1) halo fixator, 2) ventral stabilization procedure.<br />
Explanation:<br />
GoR 0<br />
The halo fixator is indicated if there are contraindications to definitive internal osteosynthesis,<br />
which is actually necessary, and a soft cervical collar is insufficient for temporary stabilization<br />
[51, 52, 53, 54].<br />
Ventral spondylodesis is indicated particularly in C3-C7 dislocation fractures. Generally, the<br />
first-line choice is corpectomy - removal of the invertebral disc, replacement with iliac crest<br />
bone graft, if necessary, a cage, and stabilization using a plate, if necessary, a fixed-angle one<br />
[55]. In polytrauma, preference should be given to the ventral management of unstable cervical<br />
spine fractures over the dorsal stabilizing procedure particularly on the day of the accident [56].<br />
According to Brodke et al. [57], there are no significant differences in the knitting, in the success<br />
of reduction, in neurology, and in the long-term symptoms for ventral versus dorsal cervical<br />
spine procedures but the latter requires much more effort and time, which is why it should not be<br />
recommended in polytrauma. If there is an unstable Dens fracture, ventral screwing is generally<br />
indicated; if there is an unstable Jefferson fracture, dorsal screwing or occipitocervical fusion can<br />
be indicated. However, the latter procedure does not represent a good indication for Day 1<br />
Surgery and should be performed as an electively planned procedure.<br />
Key recommendation:<br />
For injuries to the thoracolumbar spine, the dorsal internal fixator should be<br />
used as the primary surgical method.<br />
Explanation:<br />
GoR B<br />
Only the dorsal internal fixator can be recommended for the primary management of fractures to<br />
the thoracolumbar spine [59-61]. This procedure can achieve good reduction, decompression,<br />
and stabilization, sufficient for all positioning measures in intensive care. According to<br />
Kossmann et al., this measure is understood as damage control for the spine in polytrauma [62].<br />
Ventral fusions are recommended only electively and then in the secondary surgery phase if they<br />
are necessary. Moreover, according to Been and Bouma, dorsal stabilization on its own can be<br />
sufficient in burst fractures of the thoracic/lumbar spine [63]. The logistic and technical effort<br />
plus surgery time must be taken into account for the various surgical methods on the spine.<br />
Laminectomy increases instability [23, 65–68] and at best can serve as access for dorsal<br />
decompression to push forward posterior edge fragments. There is dispute over whether<br />
Emergency surgery phase – Spine 358
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
removing bone fragments from the spinal canal (spinal clearance) is really clinically<br />
advantageous [69-71]. Insofar as there is an indication for laminectomy, it should be made very<br />
narrowly and only considered if there is neurologic deficit and compression caused by bone and<br />
invertebral disc fragments which cannot be removed ventrally.<br />
Emergency surgery phase – Spine 359
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Kohler A, Friedl HP, Kach K, Stocker R, Trentz O.<br />
Versorgungskonzept beim <strong>Polytrauma</strong>tisierten mit<br />
Halswirbelsäulenverletzung. Helv Chir Acta. 1994<br />
Apr;60(4):547-50 [LoE 5].<br />
2. Richter-Turtur M. Wirbelsaulenverletzungen bei<br />
polytraumatisierten Patienten. Langenbecks Arch Chir<br />
Suppl Kongressbd. 1992;109:311-5 [LoE 5].<br />
3. Deutsche Gesellschaft für Unfallchirurgie.<br />
Verletzungen der Halswirbelsäule. In: Stürmer KM,<br />
Deutsche Gesellschaft für Unfallchirurgie, editors.<br />
Leitlinien Unfallchirurgie (2 Auflage). Stuttgart:<br />
Thieme; 1999. p. 34-54 [LoE 5].<br />
4. Blauth M, Knop C, Bastian L, Krettek C, Lange U.<br />
Komplexe Verletzungen der Wirbelsäule. Orthopäde.<br />
1998 Jan;27(1):17-31 [LoE 5].<br />
5. Hebert JS, Burnham RS. The effect of polytrauma in<br />
persons with traumatic spine injury. A prospective<br />
database of spine fractures. Spine. 2000 Jan;25(1):55-<br />
60.<br />
6. Tator CH, Fehlings MG, Thorpe K, Taylor W.<br />
Current use and timing of spinal surgery for<br />
management of acute spinal surgery for management<br />
of acute spinal cord injury in North America: results<br />
of a retrospective multicenter study. J Neurosurg<br />
Spine. 1999 Jul;91(1):12-8 [LoE 5].<br />
7. Croce MA, Bee TK, Pritchard E, Miller PR, Fabian<br />
TC. Does optimal timing for spine fracture fixation<br />
exist? Ann Surg. 2001 Jun;233(6):851-8 [LoE 5].<br />
8. Johnson KD, Cadambi A, Seibert GB. Incidence of<br />
adult respiratory distress syndrome in patients with<br />
multiple musculoskeletal injuries: effect of early<br />
operative stabilization of fractures. J Trauma. 1985<br />
May;25(5):375-84 [LoE 5].<br />
9. Wolter D, Eggers C, Hoser H, Krumbiegel A.<br />
Wirbelsäulen- und Beckenfrakturen im Rahmen der<br />
Mehrfachverletzung. Chirurg. 1987 Oct;58(10):648-<br />
55 [LoE 5].<br />
10. Delamarter RB, Sherman JE, Carr JB. Cauda equina<br />
syndrome: neurologic recovery following immediate,<br />
early, or late decompression. Spine. 1991<br />
Sep;16(9):1022-9 [LoE 5].<br />
11. Dolan EJ, Tator CH, Endrenyi L. The value of<br />
decompression for acute experimental spinal cord<br />
compression injury. J Neurosurg. 1980<br />
Dec;53(6):749-55 [LoE 5].<br />
12. La Rosa G, Conti A, Cardali S, Cacciola F, Tomasello<br />
F. Does early decompression improve neurological<br />
outcome of spinal cord injured patients? Appraisal of<br />
the literature using a meta-analytical approach. Spinal<br />
Cord. 2004 Sep;42(9):503-12 [LoE 2a].<br />
13. Fehlings MG, Tator CH. An evidence-based review of<br />
decompressive surgery in acute spinal cord injury:<br />
rationale, indications, and timing based on<br />
experimental and clinical studies. J Neurosurg Spine.<br />
1999 Jul;91(1):1-11 [LoE 2a].<br />
14. Fehlings MG, Sekhon LH, Tator C. The role and<br />
timing of decompression in acute spinal cord injury:<br />
what do we know? What should we do? Spine. 2001<br />
Dec 15;26(24 Suppl):S101-10 [LoE 2a].<br />
15. Silber JS, Vaccaro AR. Summary statement: the role<br />
and timing of decompression in acute spinal cord<br />
injury: evidence-based guidelines [comment]. Spine.<br />
2001 Dec 15;26(24 Suppl):S110 [Evidenzbasierte<br />
Leitlinie]<br />
16. Vaccaro AR, Daugherty RJ, Sheehan TP, Dante SJ,<br />
Cotler JM, Balderston RA, et al. Neurologic outcome<br />
of early versus late surgery for cervical spinal cord<br />
injury. Spine. 1997 Nov 15;22(22):2609-13 [LoE 1b].<br />
17. Levi L, Wolf A, Rigamonti D, Ragheb J, Mirvis S,<br />
Robinson WL. Anterior decompression in cervical<br />
spine trauma: does the timing of surgery affect the<br />
outcome? Neurosurgery. 1991 Aug;29(2):216-22<br />
[LoE 2b].<br />
18. Wagner FC, Jr., Chehrazi B. Early decompression and<br />
neurological outcome in acute cervical spinal cord<br />
injuries. J Neurosurg. 1982 May;56(5):699-705 [LoE<br />
2b].<br />
19. McKinley W, Meade MA, Kirshblum S, Barnard B.<br />
Outcomes of early surgical management versus late or<br />
no surgical intervention after acute spinal cord injury.<br />
Arch Phys Med Rehabil. 2004 Nov;85(11):1818-25<br />
[LoE 2b].<br />
20. Papadopoulos SM, Selden NR, Quint DJ, Patel N,<br />
Gillespie B, Grube S. Immediate spinal cord<br />
decompression for cervical spinal cord injury:<br />
feasibility and outcome. J Trauma. 2002<br />
Feb;52(2):323-32 [LoE 2b].<br />
21. Mirza SK, Kr<strong>eng</strong>el WF, 3rd, Chapman JR, Anderson<br />
PA, Bailey JC, Grady MS, et al. Early versus delayed<br />
surgery for acute cervical spinal cord injury. Clin<br />
Orthop. 1999 Feb(359):104-14 [LoE 2b].<br />
22. Dai LY, Yao WF, Cui YM, Zhou Q. Thoracolumbar<br />
fractures in patients with multiple injuries: diagnosis<br />
and treatment-a review of 147 cases. J Trauma. 2004<br />
Feb;56(2):348-55 [LoE 2b].<br />
23. Aebi M, Mohler J, Zach GA, Morscher E. Indication,<br />
surgical technique, and results of 100 surgicallytreated<br />
fractures and fracture-dislocations of the<br />
cervical spine. Clin Orthop. 1986 Feb(203):244-57<br />
[LoE 4].<br />
24. Kerwin AJ, Frykberg ER, Schinco MA, Griffen MM,<br />
Murphy T, Tepas JJ. The effect of early spine fixation<br />
on non-neurologic outcome. J Trauma. 2005<br />
Jan;58(1):15-21 [LoE 2b].<br />
25. McLain RF, Benson DR. Urgent surgical stabilization<br />
of spinal fractures in polytrauma patients. Spine. 1999<br />
Aug 15;24(16):1646-54 [LoE 2b].<br />
26. Schlegel J, Bayley J, Yuan H, Fredricksen B. Timing<br />
of surgical decompression and fixation of acute spinal<br />
fractures. J Orthop Trauma. 1996;10(5):323-30 [LoE<br />
2b].<br />
27. Chipman JG, Deuser WE, Beilman GJ. Early surgery<br />
for thoracolumbar spine injuries decreases<br />
complications. J Trauma. 2004 Jan;56(1):52-7 [LoE<br />
2b].<br />
Emergency surgery phase – Spine 360
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
28. Beaunoyer M, St-Vil D, Lallier M, Blanchard H.<br />
Abdominal injuries associated with thoraco-lumbar<br />
fractures after motor vehicle collision. J Pediatr Surg.<br />
2001 May;36(5):760-2 [LoE 4].<br />
29. Dalvie SS, Burwell M, Noordeen MH. Haemothorax<br />
and thoracic spinal fracture. A case for early<br />
stabilization. Injury. 2000 May;31(4):269-70 [LoE 4].<br />
30. Petitjean ME, Mousselard H, Pointillart V, Lassie P,<br />
Senegas J, Dabadie P. Thoracic spinal trauma and<br />
associated injuries: should early spinal decompression<br />
be considered? J Trauma. 1995 Aug;39(2):368-72<br />
[LoE 4].<br />
31. C<strong>eng</strong>iz SL, Kalkan E, Bayir A, Ilik K, Basefer A.<br />
Timing of thoracolomber spine stabilization in trauma<br />
patients; impact on neurological outcome and clinical<br />
course. A real prospective (rct) randomized controlled<br />
study. Arch Orthop Trauma Surg. 2008<br />
Sep;128(9):959-66.<br />
32. Albert TJ, Kim DH. Timing of surgical stabilization<br />
after cervical and thoracic trauma. Invited submission<br />
from the Joint Section Meeting on Disorders of the<br />
Spine and Peripheral Nerves, March 2004. J<br />
Neurosurg Spine. 2005 Sep;3(3):182-90.<br />
33. Bagnall AM, Jones L, Duffy S, Riemsma RP. Spinal<br />
fixation surgery for acute traumatic spinal cord injury.<br />
Cochrane Database Syst Rev. 2008(1):CD004725.<br />
34. Ball JR, Sekhon LH. Timing of decompression and<br />
fixation after spinal cord injury--when is surgery<br />
optimal? Crit Care Resusc. 2006 Mar;8(1):56-63.<br />
35. Fehlings MG, Perrin RG. The role and timing of early<br />
decompression for cervical spinal cord injury: update<br />
with a review of recent clinical evidence. Injury. 2005<br />
Jul;36 Suppl 2:B13-26.<br />
36. Fehlings MG, Perrin RG. The timing of surgical<br />
intervention in the treatment of spinal cord injury: a<br />
systematic review of recent clinical evidence. Spine.<br />
2006 May 15;31(11 Suppl):S28-35; discussion S6.<br />
37. Frangen TM, Ruppert S, Muhr G, Schinkel C.<br />
[Respiratory failure in thoracic spine injuries. Does<br />
the timing of dorsal stabilization have any effect on<br />
the clinical course in multiply injured patients?].<br />
Orthopade. 2007 Apr;36(4):365-71.<br />
38. Kerwin AJ, Griffen MM, Tepas JJ, 3rd, Schinco MA,<br />
Devin T, Frykberg ER. Best practice determination of<br />
timing of spinal fracture fixation as defined by<br />
analysis of the National Trauma Data Bank. J Trauma.<br />
2008 Oct;65(4):824-30; discussion 30-1.<br />
39. Kishan S, Vives MJ, Reiter MF. Timing of surgery<br />
following spinal cord injury. J Spinal Cord Med.<br />
2005;28(1):11-9.<br />
40. McHenry TP, Mirza SK, Wang J, Wade CE, O'Keefe<br />
GE, Dailey AT, et al. Risk factors for respiratory<br />
failure following operative stabilization of thoracic<br />
and lumbar spine fractures. J Bone Joint Surg Am.<br />
2006 May;88(5):997-1005.<br />
41. Rutges JP, Oner FC, Leenen LP. Timing of thoracic<br />
and lumbar fracture fixation in spinal injuries: a<br />
systematic review of neurological and clinical<br />
outcome. Eur Spine J. 2007 May;16(5):579-87.<br />
42. Schinkel C, Anastasiadis AP. The timing of spinal<br />
stabilization in polytrauma and in patients with spinal<br />
cord injury. Curr Opin Crit Care. 2008 Dec;14(6):685-<br />
9.<br />
43. Schinkel C, Frangen TM, Kmetic A, Andress HJ,<br />
Muhr G. [Spinal fractures in multiply injured patients:<br />
an analysis of the German Trauma Society's Trauma<br />
Register]. Unfallchirurg. 2007 Nov;110(11):946-52.<br />
44. Schinkel C, Frangen TM, Kmetic A, Andress HJ,<br />
Muhr G. Timing of thoracic spine stabilization in<br />
trauma patients: impact on clinical course and<br />
outcome. J Trauma. 2006 Jul;61(1):156-60; discussion<br />
60.<br />
45. Schinkel C, Greiner-Perth R, Schwienhorst-<br />
Pawlowsky G, Frangen TM, Muhr G, Bohm H. [Does<br />
timing of thoracic spine stabilization influence<br />
perioperative lung function after trauma?]. Orthopade.<br />
2006 Mar;35(3):331-6.<br />
46. Jacobs RR, Asher MA, Snider RK. Thoracolumbar<br />
spinal injuries. A comparative study of recumbent and<br />
operative treatment in 100 patients. Spine. 1980 Sep-<br />
Oct;5(5):463-77 [LoE 2b].<br />
47. Wood KB, Bohn D, Mehbod A. Anterior versus<br />
posterior treatment of stable thoracolumbar burst<br />
fractures without neurologic deficit: a prospective,<br />
randomized study. J Spinal Disord Tech. 2005 Feb;18<br />
Suppl:S15-23 [LoE 2b].<br />
48. Wood K, Buttermann G, Mehbod A, Garvey T,<br />
Jhanjee R, Sechriest V, et al. Operative compared<br />
with nonoperative treatment of a thoracolumbar burst<br />
fracture without neurological deficit. A prospective,<br />
randomized study. J Bone Joint Surg Am. 2003<br />
May;85-A(5):773-81 [LoE 1b].<br />
49. Resch H, Rabl M, Klampfer H, Ritter E, Povacz P.<br />
Operative vs. konservative Behandlung von Frakturen<br />
des thorakolumbalen Übergangs. Unfallchirurg. 2000<br />
Apr;103(4):281-8 [LoE 2b].<br />
50. Knight RQ, Stornelli DP, Chan DP, Devanny JR,<br />
Jackson KV. Comparison of operative versus<br />
nonoperative treatment of lumbar burst fractures. Clin<br />
Orthop. 1993 Aug(293):112-21 [LoE 2b].<br />
51. von Gumppenberg S, Vieweg J, Claudi B, Harms J.<br />
Die primäre Versorgung der frischen Verletzungen<br />
von Brust- und Lendenwirbelsäule. Aktuelle<br />
Traumatol. 1991 Dec;21(6):265-73 [LoE 4].<br />
52. Heary RF, Hunt CD, Krieger AJ, Antonio C,<br />
Livingston DH. Acute stabilization of the cervical<br />
spine by halo/vest application facilitates evaluation<br />
and treatment of multiple trauma patients. J Trauma.<br />
1992 Sep;33(3):445-51 [LoE 4].<br />
53. Hertz H, Scharf W. Stabilisierung der Halswirbelsäule<br />
mit dem Halo-Fixateur-externe für Flugtransporte.<br />
Wien Med Wochenschr. 1982 Jan 15;132(1):11-3<br />
[LoE 4].<br />
54. Kleinfeld F. Zur Behandlung von Frakturen der<br />
Halswirbelsäule mit dem Halo-Fixateur externe.<br />
Unfallheilkunde. 1981 Apr;84(4):161-7 [LoE 4].<br />
55. Daentzer D, Böker DK. Operative Stabilisierung<br />
traumatischer Instabilitaten der unteren<br />
Halswirbelsäule. Erfahrungen mit einem nicht<br />
winkelstabilen ventralen Platten-Schrauben-System<br />
bei 95 Patienten. Unfallchirurg. 2004 Mar;107(3):175-<br />
80 [LoE 4].<br />
Emergency surgery phase – Spine 361
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
56. Koivikko MP, Myllynen P, Karjalainen M, Vornanen<br />
M, Santavirta S. Conservative and operative treatment<br />
in cervical burst fractures. Arch Orthop Trauma Surg.<br />
2000;120(7-8):448-51 [LoE 4].<br />
57. Brodke DS, Anderson PA, Newell DW, Grady MS,<br />
Chapman JR. Comparison of anterior and posterior<br />
approaches in cervical spinal cord injuries. J Spinal<br />
Disord Tech. 2003 Jun;16(3):229-35 [LoE 1b].<br />
58. Marshall LF, Knowlton S, Garfin SR, Klauber MR,<br />
Eisenberg HM, Kopaniky D, et al. Deterioration<br />
following spinal cord injury. A multicenter study. J<br />
Neurosurg. 1987 Mar;66(3):400-4.<br />
59. Schweighofer F, Hofer HP, Wildburger R,<br />
Stockenhuber N, Bratschitsch G. Unstable fractures of<br />
the upper thoracic spine. Langenbecks Arch Chir.<br />
1997;382(1):25-8 [LoE 4].<br />
60. Pizanis A, Mutschler W. Dorsale Stabilisierung von<br />
Frakturen der Brust- und Lendenwirbelsäule durch<br />
den Fixateur interne: Technik und Ergebnisse.<br />
Zentralbl Chir. 1998;123(8):936-43 [LoE 4].<br />
61. Knop C, Blauth M, Bühren V, Arand M, Egbers HJ,<br />
Hax PM, et al. Operative Behandlung von<br />
Verletzungen des thorakolumbalen Übergangs - Teil<br />
3: Nachuntersuchung. Ergebnisse einer prospektiven<br />
multizentrischen Studie der Arbeitsgemeinschaft<br />
"Wirbelsäule" der Deutschen Gesellschaft für<br />
Unfallchirurgie. Unfallchirurg. 2001 Jul;104(7):583-<br />
600 [LoE 4].<br />
62. Kossmann T, Trease L, Freedman I, Malham G.<br />
Damage control surgery for spine trauma. Injury.<br />
2004 Jul;35(7):661-70 [LoE 5].<br />
63. Been HD, Bouma GJ. Comparison of two types of<br />
surgery for thoraco-lumbar burst fractures: combined<br />
anterior and posterior stabilisation vs. posterior<br />
instrumentation only. Acta Neurochir (Wien).<br />
1999;141(4):349-57 [LoE 2b].<br />
64. Aebi M. Brust- und Lebenwirbelsäulen-Therapie. In:<br />
Witt AN, Rettig H, Schlegel KF, editors. Orthopädie<br />
in Praxis und Klinik, Spezielle Orthopädie<br />
(Wirbelsäule-Thorax-Becken). Stuttgart: Thieme;<br />
1994. p. 3.133-8.<br />
65. Lu WW, Luk KD, Ruan DK, Fei ZQ, Leong JC.<br />
Stability of the whole lumbar spine after multilevel<br />
fenestration and discectomy. Spine. 1999 Jul<br />
1;24(13):1277-82 [LoE 5].<br />
66. Degreif J, Wenda K, Runkel M, Ritter G. Die<br />
Rotationsstabilität der thorakolumbalen Wirbelsäule<br />
nach interlaminarem Schallfenster,<br />
Hemilaminektomie und Laminektomie. Eine<br />
vergleichende experimentelle Studie. Unfallchirurg.<br />
1994 May;97(5):250-5 [LoE 5].<br />
67. Zander T, Rohlmann A, Klockner C, Bergmann G.<br />
Influence of graded facetectomy and laminectomy on<br />
spinal biomechanics. Eur Spine J. 2003<br />
Aug;12(4):427-34 [LoE 5].<br />
68. Tencer AF, Allen BL, Jr., Ferguson RL. A<br />
biomechanical study of thoracolumbar spinal fractures<br />
with bone in the canal. Part I. The effect of<br />
laminectomy. Spine. 1985 Jul-Aug;10(6):580-5 [LoE<br />
5].<br />
69. Boerger TO, Limb D, Dickson RA. Does 'canal<br />
clearance' affect neurological outcome after<br />
thoracolumbar burst fractures? J Bone Joint Surg Br.<br />
2000 Jul;82(5):629-35 [LoE 2a].<br />
70. Limb D, Shaw DL, Dickson RA. Neurological injury<br />
in thoracolumbar burst fractures. J Bone Joint Surg<br />
Br. 1995 Sep;77(5):774-7 [LoE 4].<br />
71. Wessberg P, Wang Y, Irstam L, Nordwall A. The<br />
effect of surgery and remodelling on spinal canal<br />
measurements after thoracolumbar burst fractures. Eur<br />
Spine J. 2001 Feb;10(1):55-63 [LoE 4].<br />
Emergency surgery phase – Spine 362
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.8 Upper extremity<br />
Key recommendation:<br />
Surgical management of fractures to the long bones in the upper extremities<br />
should be carried out early.<br />
Explanation:<br />
GoR B<br />
There are no prospective comparative studies on the determination of the optimum timing for the<br />
surgical management of fractures of the long bones in the upper extremity in multiply injured<br />
patients. The data is based on studies which either focus on primary shaft fractures of the lower<br />
extremity in polytrauma or analyze multiply injured patients in the total collective with single<br />
fractures of the long bones of the upper extremity.<br />
Shaft fractures of the upper extremity must be surgically managed early, if possible directly after<br />
cardio-respiratory stabilization [1].<br />
If concerns exist over primary internal fixation, the alternative option is provided by the external<br />
fixator or, in exceptional cases, even primary plaster cast and later change in procedure [2].<br />
After initial stabilization by external fixator, plaster cast or re-applied dressing, even fractures<br />
close to the joint can be managed well by secondary surgery if planned, if the acute problems of<br />
other injuries make this necessary [3].<br />
Open fractures are best operated on within the first 6 hours, if necessary with temporary<br />
stabilizing measures.<br />
In the hierarchy of urgency, however, there is also a correlation with the location of other<br />
fractures. In multiply injured patients, therefore, the priority of fractures in the upper extremity<br />
follows management of tibia, femur, pelvis, and spine but precedes complex joint<br />
reconstructions, definitive treatment of maxillofacial injuries, and soft tissue reconstructions [4].<br />
There are no comparative studies that deal specifically with the most suitable procedure in<br />
fractures of the upper extremity in multiply injured patients. The multiply injured patient is<br />
always included in heterogeneous groups as an important indication for the surgical procedure.<br />
Thus, the conclusion by analogy is generally drawn from the totality of the patients with<br />
fractures of the long bones of the upper extremity.<br />
However, there are no large studies here either that reflect a high level of evidence. The AO<br />
multicenter study on the humerus shaft fracture also no longer represents all current procedures<br />
[5].<br />
In the management of fractures of the upper extremity in multiply injured patients, the focus lies<br />
on the rapid but safe stabilization of the fracture to the upper extremity. Within this context,<br />
controversy surrounds the ranking between medullary nailing and plate osteosynthesis as the<br />
Emergency surgery phase – Upper extremity 363
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
competence of the surgeon in one or the other procedure appears to be more important than the<br />
procedure itself [3, 6–12].<br />
In metaphyseal fractures to the humerus, radius, and ulna, specific intramedullary procedures are<br />
now also used; studies with informative value on their use in multiply injured patients are not<br />
available.<br />
Key recommendations:<br />
The decision to amputate or to salvage the extremity in the critical injury to<br />
the upper extremity should be made on an individual basis. The local and<br />
general condition of the patient plays a crucial role here.<br />
In rare cases and in extremely severe injuries, an amputation can be<br />
recommended.<br />
Explanation:<br />
GoR B<br />
GoR 0<br />
In subtotal amputation injuries, fracture stabilization and reconstruction of nerves, vessels, and<br />
soft tissues should be carried out immediately after the resuscitation phase and management of<br />
vital sign injuries, if necessary also while shortening the extremity.<br />
In the case of total amputation injuries, the availability and condition of the lost extremity are<br />
key to deciding whether it makes sense to replant or definitively amputate to create a vital stump.<br />
Even extremely contaminated, severe open fractures do not represent per se an indication for<br />
primary amputation in multiply injured patients. Stabilization and debridement are important in<br />
this instance [15]. The literature contains mainly case histories on this subject [16].<br />
The Mangled Extremity Severity Score (MESS) developed for the lower extremities [17] cannot<br />
be simply transferred to the upper extremity.<br />
Emergency surgery phase – Upper extremity 364
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
Provided the severity of the overall injury permits, the surgical management<br />
of vascular injuries should be carried out at the earliest possible opportunity,<br />
i.e. directly after treating the injuries threatening the vital functions.<br />
Explanation:<br />
GoR B<br />
Due to the rapid onset and poor prognosis associated with ischemic sequelae, vascular<br />
reconstruction must be carried out rapidly in polytrauma as well [18–20].<br />
Absent pulses in the pendant parts of the extremity affected can give information about an<br />
additional vascular injury or even a vascular injury without a fracture; Doppler and duplex<br />
supplement the diagnostic study [18, 19].<br />
Schlickewei et al. recommend the generous use of preoperative angiography in injuries to the<br />
upper extremity and the urgent surgical restoration of perfusion to the extremities to reduce the<br />
period of ischemia [20]. In the case of those injuries that required secondary amputation in<br />
conjunction with the vascular injury, the period of ischemia exceeded 6 hours in 51.8% of cases,<br />
there was severe soft tissue damage in 81.4%, and a grade III open fracture in 85.2%. However,<br />
reconstructive interventions are put to one side if vital functions are at risk. Due to low case<br />
numbers, there are only isolated case series on this [18–20].<br />
Key recommendation:<br />
Depending on the type of nerve damage, injuries with nerve involvement<br />
should be managed together with stabilization.<br />
Explanation:<br />
GoR B<br />
The majority of multiply injured patients are ventilated and intubated on admission to hospital<br />
but the sensitivity and motor functions of the fractured upper extremity often cannot be clearly<br />
examined at the accident scene. The rate of primary non-discovered concomitant nerve damage<br />
is unclear. Provided it is not simply a question of decompression as part of the fracture<br />
management, the correct reconstruction of peripheral nerve lesions in the long bone region of the<br />
upper extremity is time-consuming and complex and should be planned and carried out in a<br />
stable environment. Thus, this should only be integrated into the primary management of<br />
multiply injured patients in exceptional cases. This does not only apply to the injury to isolated<br />
peripheral nerves but also to brachial plexus injuries [21–25].<br />
Due to low case numbers, there are only isolated case series which are not exclusively limited to<br />
polytrauma.<br />
Compartment syndromes associated with fractures of long bones in the upper extremity are rare.<br />
Due to deleterious sequelae occurring within a few hours, however, they require rapid<br />
Emergency surgery phase – Upper extremity 365
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
decompression during fracture stabilization. This applies equally to multiply injured and to nonmultiply<br />
injured patients and should take place within the first few hours after trauma and<br />
compartment syndrome development. Wippermann et al. [26] showed for the upper arm and<br />
Schmidt et al. [27] showed for the forearm that the prognosis depends on the totality of the<br />
injuries and is most favorable in the case of isolated compartment syndrome without fracture.<br />
Nevertheless, the conclusion of rapid action is based less on specific studies on compartment<br />
syndrome in the upper extremity in polytrauma but rather much more on the experiences with the<br />
lower extremity (Evidence Level 5). Open fractures and those with vascular injuries should thus<br />
undergo rapid surgical revision after restoration of cardiopulmonary stability. In closed fractures,<br />
those with impairment of the epiphyseal gaps represent an urgent surgical indication after<br />
stabilization of the vital functions. For logical reasons, shaft fractures in the long bone in<br />
multiply injured children are fixed outside the epiphyseal gaps by means of elastic<br />
intramedullary splinting[28]; alternatively, the external fixator can be used. Bennek [29]<br />
envisages its use particularly in open and long-segment fractures. As with Schranz [30], the case<br />
numbers are very small in this respect. Nevertheless, the procedure should be adapted to the age<br />
of the child as well as to his concomitant injuries [31, 32]. Due to low case numbers, there are<br />
only isolated case series which are not exclusively limited to polytrauma.<br />
Emergency surgery phase – Upper extremity 366
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Rommens, P.M., et al., [Indications, dangers and<br />
results of surgical treatment of humeral shaft<br />
fractures]. Unfallchirurg, 1989. 92(12): p. 565-70<br />
[LoE 3b].<br />
2. Weise, K., S. Weller, and U. Ochs, [Change in<br />
treatment procedure after primary external fixator<br />
osteosynthesis in polytrauma patients]. Aktuelle<br />
Traumatol, 1993. 23(4): p. 149-68.<br />
3. Bleeker, W.A., M.W. Nijsten, and H.J. ten Duis,<br />
Treatment of humeral shaft fractures related to<br />
associated injuries. A retrospective study of 237<br />
patients. Acta Orthop Scand, 1991. 62(2): p. 148-53.<br />
4. Tscherne, H., et al., Internal fixation of multiple<br />
fractures in patients with polytrauma. Clin Orthop<br />
Relat Res, 1998(347): p. 62-78 [LoE 2a].<br />
5. Nast-Kolb, D., W.T. Knoefel, and L. Schweiberer,<br />
[The treatment of humeral shaft fractures. Results of a<br />
prospective AO multicenter study]. Unfallchirurg,<br />
1991. 94(9): p. 447-54.<br />
6. Bell, M.J., et al., The results of plating humeral shaft<br />
fractures in patients with multiple injuries. The<br />
Sunnybrook experience. J Bone Joint Surg Br, 1985.<br />
67(2): p. 293-6.<br />
7. Blum, J., et al., [Retrograde nailing of humerus shaft<br />
fractures with the unreamed humerus nail. An<br />
international multicenter study]. Unfallchirurg, 1998.<br />
101(5): p. 342-52.<br />
8. Bonnaire, F. and M. Seif El Nasr, Indikation und<br />
Technik der Plattenosteosynthese am Oberarmschaft.<br />
Aktuelle Traumatol, 1997. 27: p. 86-90.<br />
9. Brumback, R.J., et al., Intramedullary stabilization of<br />
humeral shaft fractures in patients with multiple<br />
trauma. J Bone Joint Surg Am, 1986. 68(7): p. 960-70.<br />
10. Rommens, P.M., J. Blum, and M. Runkel, Retrograde<br />
nailing of humeral shaft fractures. Clin Orthop Relat<br />
Res, 1998(350): p. 26-39.<br />
11. Rommens, P.M., J. Verbruggen, and P.L. Broos,<br />
Retrograde locked nailing of humeral shaft fractures.<br />
A review of 39 patients. J Bone Joint Surg Br, 1995.<br />
77(1): p. 84-9.<br />
12. Vander Griend, R., J. Tomasin, and E.F. Ward, Open<br />
reduction and internal fixation of humeral shaft<br />
fractures. Results using AO plating techniques. J Bone<br />
Joint Surg Am, 1986. 68(3): p. 430-3.<br />
13. Knopp, W., K. Neumann, and G. Muhr, [Management<br />
of complicated fractures of the forearm. External<br />
fixation and early changes in procedures].<br />
Unfallchirurg, 1988. 91(12): p. 539-44.<br />
14. Hinsenkamp, M., F. Burny, and Y. Adrianne, External<br />
fixation of the fracture of the humerus. A review of<br />
164 cases. Orthopaedics, 1984. 7: p. 1309-14.<br />
15. Levin, L.S., et al., Management of severe<br />
musculoskeletal injuries of the upper extremity. J<br />
Orthop Trauma, 1990. 4(4): p. 432-40.<br />
16. Kaleli, T. and R.A. Ozerdemoglu, Traumatic forearm<br />
amputation with avulsions of the ulnar and median<br />
nerves from the brachial plexus. Arch Orthop Trauma<br />
Surg, 1998. 118(1-2): p. 119-20.<br />
17. Johansen, K., et al., Objective criteria accurately<br />
predict amputation following lower extremity trauma.<br />
J Trauma, 1990. 30(5): p. 568-72; discussion 572-3.<br />
18. Karas, E.H., E. Strauss, and S. Sohail, Surgical<br />
stabilization of humeral shaft fractures due to gunshot<br />
wounds. Orthop Clin North Am, 1995. 26(1): p. 65-73<br />
[LoE 4].<br />
19. Richter, A., et al., [Peripheral vascular injuries in<br />
polytrauma]. Unfallchirurg, 1995. 98(9): p. 464-7<br />
[LoE 4].<br />
20. Schlickewei, W., et al., Upper and lower limb<br />
fractures with concomitant arterial injury. J Bone Joint<br />
Surg Br, 1992. 74(2): p. 181-8 [LoE 4].<br />
21. Dabezies, E.J., et al., Plate fixation of the humeral<br />
shaft for acute fractures, with and without radial nerve<br />
injuries. J Orthop Trauma, 1992. 6(1): p. 10-3.<br />
22. Kwasny, O. and R. Maier, [The significance of nerve<br />
damage in upper arm fractures]. Unfallchirurg, 1991.<br />
94(9): p. 461-7.<br />
23. Nast-Kolb, D., S. Ruchholtz, and L. Schweiberer, Die<br />
Bedeutung der Radialisparese für die Wahl des<br />
Behandlungsverfahrens der Humerusschaftfraktur.<br />
Aktuelle Traumatol, 1997. 27: p. 100-4.<br />
24. Pollock, F.H., et al., Treatment of radial neuropathy<br />
associated with fractures of the humerus. J Bone Joint<br />
Surg Am, 1981. 63(2): p. 239-43.<br />
25. Sonneveld, G.J., et al., Treatment of fractures of the<br />
shaft of the humerus accompanied by paralysis of the<br />
radial nerve. Injury, 1987. 18(6): p. 404-6.<br />
26. Wippermann, B., U. Schmidt, and M. Nerlich,<br />
[Results of treatment of compartment syndrome of the<br />
upper arm]. Unfallchirurg, 1991. 94(5): p. 231-5 [LoE<br />
4].<br />
27. Schmidt, U., A. Tempka, and M. Nerlich,<br />
[Compartment syndrome of the forearm].<br />
Unfallchirurg, 1991. 94(5): p. 236-9 [LoE 4].<br />
28. Verstreken, L., [Orthopedic treatment of the child<br />
with multiple injuries and its current progress]. Acta<br />
Chir Belg, 1990. 90(4): p. 177-84 [LoE 4].<br />
29. Bennek, J., The use of upper limb external fixation in<br />
paediatric trauma. Injury, 2000. 31 Suppl 1: p. 21-6<br />
[LoE 4].<br />
30. Schranz, P.J., C. Gultekin, and C.L. Colton, External<br />
fixation of fractures in children. Injury, 1992. 23(2): p.<br />
80-2 [LoE 4].<br />
31. Machan, F.G. and H. Vinz, [Humeral shaft fracture in<br />
childhood]. Unfallchirurgie, 1993. 19(3): p. 166-74<br />
[LoE 4].<br />
32. Von Laer, L., Frakturen und Luxationen im<br />
Wachstumsalter. 1996, Stuttgart, New York: Thieme<br />
[LoE 4]<br />
Emergency surgery phase – Upper extremity 367
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.9 Hand<br />
Fractures and dislocations of the distal forearm, the carpals, metacarpals, and phalanges<br />
Key recommendations:<br />
Closed fractures and dislocations should be conservatively treated in the<br />
emergency surgery phase.<br />
GoR B<br />
Dislocations must be reduced and stabilized in the emergency surgery phase. GoR A<br />
Explanation:<br />
In polytrauma, 75% of hand injuries are closed fractures [2, 91]. In principle, closed fractures<br />
and dislocations can be reduced according to clinical criteria without too much effort and<br />
immobilized by simple means (plaster, splints). However, in unstable, extremely dislocated<br />
fractures of the distal radius, metacarpals, and phalanges, primary stabilization via an external<br />
fixator and Kirschner wires is indicated after closed reduction.<br />
In the secondary phase (5th-12th day), the following injuries should be definitively operated on:<br />
unstable fractures and those remaining in intolerable malpositions, ligament injuries temporarily<br />
managed during the emergency surgery phase, and fractures.<br />
Dislocations of the finger joints represent important injuries in the prognosis of hand function. In<br />
principle, reduction must be carried out immediately [23, 69]. If closed reduction is not possible,<br />
then open reduction must be carried out in the emergency surgery phase. After primary<br />
successful reduction, a stable closed finger joint dislocation without articular fracture can be<br />
treated conservatively [4, 23, 45, 64, 66, 99, 105, 126, 134].<br />
Key recommendation:<br />
In the case of open fractures and dislocations, primary debridement and<br />
stabilization by wires or external fixator should be carried out.<br />
Explanation:<br />
GoR B<br />
Open fractures and dislocations should be managed in the emergency surgery phase. Here, the<br />
main procedure corresponds to the usual procedure for open bony injuries (dressing kept on until<br />
in surgery, wound cleaning, debridement, irrigation, fracture stabilization, soft tissue<br />
reconstruction). Fracture stabilization using the external fixator or Kirschner wires should be<br />
given preference over time-consuming primary definitive osteosynthesis (plates, screws) [5, 16,<br />
17, 38, 81, 101]. Wound irrigation and careful debridement make a crucial contribution to<br />
infection prevention [49, 112]. Carrying out a second look after 2-3 days depends on the primary<br />
Emergency surgery phase – Hand 368
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
local injury pattern and the clinical situation [49]. See the section on “Drug Treatment” for<br />
administration of antibiotics.<br />
Key recommendation:<br />
In the case of perilunar dislocation/perilunar dislocation fractures, reduction,<br />
if necessary open, must be undertaken in the emergency surgery phase.<br />
Explanation:<br />
GoR A<br />
The long-term outcomes after perilunar dislocations/dislocations of the lunate bone depend on<br />
early diagnosis and correct treatment. Reduction of the dislocated carpals is undertaken early in<br />
the emergency surgery phase either closed or, if this is not possible, open. After primary closed<br />
or open reduction, stabilization must be undertaken using Kirschner wires and/or an external<br />
fixator [40, 53, 83, 95].<br />
Definitive open reduction, internal fixation using drill wires and/or reconstruction of the torn<br />
ligaments should be undertaken in the secondary phase. Fractures as part of perilunar dislocation<br />
injuries should be managed osteosynthetically with screws or drill wires [39, 53, 56]. Whereas<br />
the injury morphology (course of fracture and dislocation line, extent of dislocation) is not<br />
important for the clinical and radiologic long-term outcome, the time until diagnosis and the<br />
accuracy and immobilization of the reduction represent relevant prognosis factors [40, 53].<br />
Amputation injuries<br />
Key recommendations:<br />
Establishing the indication for replantation must be based on the overall<br />
injury severity according to the “life before limb” principle.<br />
In establishing the indication, the local finding and patient-related factors<br />
should be taken into account.<br />
Explanation:<br />
GoR A<br />
GoR B<br />
Replantations in the hand region are possible and advisable in the multiply injured provided the<br />
severity score is 1-2 (polytrauma score [PTS]) [15, 111]. However, the indication for<br />
replantation should be kept very narrow for all those with life-threatening injuries as the surgery<br />
time is considerably extended and morbidity increased [13, 82].<br />
Negative predictors are Crush or avulsion injuries, severe contamination, warm ischemia over<br />
12 hours or cold ischemia over 24 hours, arteriosclerosis, and smoking [3, 8, 13, 24, 32, 37, 48,<br />
82, 92, 120, 121]. In the case of replantations at the level of the wrist and proximal thereto, the<br />
serum potassium concentration measured 30 minutes after reperfusion in the amputated part can<br />
be used as a prognosis indicator (critical value 6.5 mmol/l) [129].<br />
Emergency surgery phase – Hand 369
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
As with isolated hand injuries, the goal should be replantation particularly in<br />
the case of loss of thumb or several fingers, amputation at the level of<br />
metacarpals/carpals/wrist, and all amputation injuries in children.<br />
Explanation:<br />
GoR B<br />
Replantations for amputations of the thumb, several fingers, metacarpals, and wrist are priority<br />
indications [13, 32, 46, 48, 82, 92, 130, 135]. Revascularizations have a somewhat more<br />
favorable prognosis as tissue bridges still in place often improve the venous outflow [90, 100].<br />
Provided the general condition allows it, the indication for replantation should also be made in<br />
children since good functional results can be expected [28, 48, 90, 116, 136]. Positive predictors<br />
here are smooth-edged separations and a body weight exceeding 11 kg [7]. Children’s fingers<br />
tolerate markedly longer ischemic periods than those of adults [22].<br />
Key recommendation:<br />
Individual fingers should not be replanted if amputations are proximal of the<br />
superficial tendon insertion (middle phalanx base).<br />
Explanation:<br />
GoR B<br />
The amputation level of a finger is crucial in establishing the indication for replantation. In<br />
amputations of an individual finger proximal of the superficial tendon insertion, no replantation<br />
is indicated because of the poor functional result expected as a consequence of the severe<br />
mobility restriction [24, 120, 135]. In contrast, replantations are expedient in amputations that<br />
are distally further away provided the dorsal veins can be reconstructed. Good results can be<br />
achieved on the distal phalanx even without venous reconstruction [21, 37, 47, 48, 60, 68, 113].<br />
Emergency surgery phase – Hand 370
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Complex hand injury<br />
Key recommendation:<br />
Carrying out time-consuming salvage attempts on the hand is an individual<br />
decision. It must take into account the overall injury severity and the severity<br />
of the hand injury.<br />
Explanation:<br />
GoR A<br />
If there are complex hand injuries with involvement of bones, tendons, nerves, and skin, the<br />
additional strains on the patient caused by the reconstruction must be weighed up against the<br />
outlook for success and the functional gain that can be expected. Time-consuming salvage<br />
attempts in the hand region are indicated only in PTS severity grades 1 and 2 [111]. Establishing<br />
the indication for or against salvaging the hand must always take into account the individual<br />
circumstances of each patient. MESS (Mangled Extremity Severity Score), which was originally<br />
developed for the lower extremity, can serve as an additional decision aid. In prospective and<br />
retrospective studies, a positive predictor value of 100% for an amputation was also obtained for<br />
the upper extremity with a MESS value of at least 7 points [31, 52, 96].<br />
Key recommendation:<br />
Debridement and bony stabilization should be carried out in the emergency<br />
surgery phase.<br />
Explanation:<br />
GoR B<br />
Debridement and stabilization of the hand skeleton have priority in an open injury whereas<br />
nerve, tendon, and skin reconstruction can be carried out at a later time [17, 34, 81, 102, 114].<br />
Time-consuming definitive reconstructions of soft tissue structures should be carried out in the<br />
secondary phase. The advantages and disadvantages (time required, operative traumatization,<br />
mobilization) of drill wire osteosyntheses should be weighed up against those of stable<br />
osteosyntheses by plates and screws [19, 20, 34].<br />
Emergency surgery phase – Hand 371
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Skin/soft tissue injury including thermal/chemical damage<br />
Key recommendation:<br />
The initial treatment of circumferential skin-soft tissue damage should<br />
comprise thorough debridement followed by keeping moist the wound<br />
surfaces that cannot be closed in primary management.<br />
Explanation:<br />
GoR B<br />
During the emergency surgery phase, debridement of devitalized and contaminated tissue parts<br />
should be carried out [20, 101]. Keeping the wound surfaces and deeper structures moist by<br />
means of suitable dressing techniques is more important than attempting a soft tissue graft during<br />
the initial management [17].<br />
If the wounds are clean and free of infection, the definitive defect covering should be carried out<br />
during the secondary phase (5th-12th day). In so doing, the procedure selected should always be<br />
the least technically demanding one with a good outlook for success, i.e. free flaps are always the<br />
last treatment option [43, 72].<br />
Key recommendations:<br />
Thermally/chemically damaged, fully devitalized skin areas should initially be<br />
debrided.<br />
In the case of deep-reaching and circumferential thermal/chemical damage, an<br />
escharotomy should be carried out similar to the procedure for compartment<br />
syndrome.<br />
For the conservative wound treatment of superficial burns (1-2a degree),<br />
preference should be given to sulfadiazine silver ointments or synthetic<br />
dressing materials and for the temporary treatment of deep burns (2b-3<br />
degree) preference should be given to hydrocolloid dressings or vacuum<br />
sealing.<br />
Explanation:<br />
GoR B<br />
GoR B<br />
GoR B<br />
Burns require initial debridement by removing all definitely devitalized areas to prevent<br />
circulatory disorders and infections. If full skin loss is subsequently present, a primary meshed<br />
graft covering should be given preference over secondary skin grafting. The primary grafting<br />
shortens the treatment period and reduces the frequency of secondary reconstructive operations<br />
[14, 67]. In the case of deep burns, the indication for escharotomy must be monitored within the<br />
Emergency surgery phase – Hand 372
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
first 36 hours by regularly monitoring local perfusion [1] (see section on Compartment<br />
Syndrome for indication and technique).<br />
Silver sulfadiazine cream is suitable for treating superficial areas not requiring debridement; it<br />
should be re-applied each time after daily wound cleaning. Alternatively, synthetic dressings can<br />
be used. In the case of deeper burns, preference should be given to hydrocolloid dressings or<br />
vacuum seals as these lead to shorter healing courses and a reduction in pain [6, 93, 94, 98, 117].<br />
In a controlled trial, faster healing of partial burns could be achieved through the use of<br />
collagenase with local antibiotics than through conventional treatment with sulfadiazine [50]. If<br />
secondary demarcated necroses occur under this treatment, they must also be removed. If healing<br />
is uncertain after 3 weeks, a skin graft, possibly after debridement again, should be carried out to<br />
avoid hypertrophic scarring and contractures [14, 67].<br />
Tendon injuries (flexor tendons, extensor tendons)<br />
Key recommendation:<br />
Time-consuming tendon sutures should not be carried out as a primary<br />
procedure.<br />
Explanation:<br />
GoR B<br />
Whether a severed flexor tendon should be managed by primary or delayed primary suture is<br />
surrounded by controversy [61, 62, 65, 106–110]. However, time-consuming tendon sutures can<br />
be carried out in multiply injured patients in the secondary phase (5th-7th day) without<br />
disadvantages being expected [20, 101, 102, 104, 107, 109, 131]. On the other hand, secondary<br />
flexor tendon reconstructions are disadvantageous (after weeks) [125].<br />
The same recommendations apply in principle to the timetable for reconstruction of extensor<br />
tendon injuries as for flexor tendon injuries. However, the extent of damage to the soft tissue<br />
sheath and open joint injuries can necessitate primary definitive management [30, 124].<br />
The choice of flexor tendon suture technique to be used depends on the preference of the surgeon<br />
as individual experience and execution are more important than the choice of suturing technique<br />
[109].<br />
In the case of both flexor tendons being severed, reconstruction of both tendons is favored [61,<br />
62, 71, 102, 106–110]. However, various authors prefer the sole reconstruction of the deep<br />
tendon in zone 2 because of better functional results [25, 57, 65]. In addition, there was evidence<br />
in a prospective randomized study that preference should be given to resection of the superficial<br />
flexor tendon and reconstruction only of the deep flexor tendon within zone 2 (Tang’s<br />
subdivision 2C), particularly in delayed primary management [115]. For this reason, only the<br />
deep tendon is to be reconstructed within zone 2 particularly in delayed primary flexor tendon<br />
suture.<br />
Routine administration of antibiotics is also not indicated in delayed primary flexor tendon<br />
suture. In a retrospective cohort study, Stone and Davidson [104] showed that not giving<br />
Emergency surgery phase – Hand 373
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
antibiotics in primary or delayed primary flexor tendon reconstruction does not increase the risk<br />
of infections occurring [104]. The administration of antibiotics to the multiply injured patient<br />
depends much more on the presence of other injuries or the occurrence of infectious<br />
complications.<br />
Nerve injuries of the hand<br />
Key recommendation:<br />
In assumed closed nerve injuries, time-consuming diagnostic procedures or<br />
surgical release can be dispensed with in the primary phase.<br />
Explanation:<br />
GoR 0<br />
Closed nerve damage to the hand is the result of the effect of pressure or extension forces. A<br />
continuity disruption to the nerves is not to be expected. For this reason, primary surgical<br />
revision is not indicated here. The only exceptions are nerve lesions due to fractures or<br />
dislocations, where the nerve can be located and decompressed during surgical management of<br />
the skeletal injury. Thus, there is also no necessity to carry out time-consuming diagnostic<br />
measures to reveal assumed lesions while the patient is still unconscious [20]. The development<br />
of clinical symptoms and neurophysiologic parameters should be awaited.<br />
Key recommendation:<br />
Surgical reconstruction of open nerve injuries should be carried out as a<br />
delayed primary suture.<br />
Explanation:<br />
GoR B<br />
Open nerve injuries require time-consuming microsurgical reconstruction. The best possible<br />
outcome must be achieved by initial nerve restoration [27]. For this reason, these interventions<br />
should be undertaken as delayed primary surgery in the secondary phase on 5th-7th day [18, 101,<br />
131]. Later secondary reconstruction leads to poorer outcomes [9, 58, 59, 70, 122]. It is helpful<br />
to identify the nerve stumps and mark as atraumatic during emergency surgery [20].<br />
Emergency surgery phase – Hand 374
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Compartment syndrome<br />
Key recommendation:<br />
If there is clinical suspicion of compartment syndrome in the hand, a pressure<br />
measurement device can be used to take a measurement.<br />
Explanation:<br />
GoR 0<br />
If there is compartment syndrome, it is crucial to establish an early diagnosis because irreversible<br />
damage is done to musculature and nerves after 8 hours at the latest [133]. The diagnosis is made<br />
in the primary phase according to clinical criteria [54, 55]. Normal pallor and temperature in the<br />
fingers and the presence of distal pulses [10, 33, 51, 54, 77, 133] do not exclude compartment<br />
syndrome. The cardinal symptom of pain and pain-provoking muscle extension and sensitivity<br />
tests cannot be used in the multiply injured patient who is generally unconscious or analgesic<br />
sedated. Provided compartment syndrome has not already been clinically diagnosed, the<br />
definitive diagnosis can be established using a pressure measurement device [79, 89].<br />
Compartment pressures exceeding 30 mmHg or, in the case of hypotension, exceeding the<br />
difference pdiastolic - 30 mmHg are classed as critical values and indication for a fasciotomy in the<br />
unconscious patient [51, 73, 77, 133].<br />
Key recommendation:<br />
If manifest compartment syndrome is present in the hand, fasciotomy must be<br />
performed immediately.<br />
Explanation:<br />
GoR A<br />
If the diagnosis of compartment syndrome has been established, an immediate fasciotomy is<br />
indicated. An early adequate dermatofasciotomy prevents ischemic contractures and represents<br />
an emergency intervention [33, 51, 54, 77, 133].<br />
If compartment syndrome has been detected clinically or by using a device, all 10 compartments<br />
in the hand should be decompressed via 4 incisions whereas in the forearm a palmar fasciotomy<br />
is generally sufficient. In the forearm, the palmar fasciotomy is started as a parathenar carpal<br />
tunnel incision and continued up to the elbow by dividing the bicipital aponeurosis, whereby a<br />
median arch-shaped and a palmar-ulnar incision line are both equally effective [42, 133]. If this<br />
does not lead to a sufficient lowering in pressure in the dorsal compartment, additional<br />
decompression via a straight median incision line is required in the dorsal forearm [42, 89]. The<br />
10 compartments in the hand must be decompressed via several incisions. The dorsal and palmar<br />
interosseous compartments can be accessed by dorsal incisions over metacarpals 2 and 4. The<br />
incision line for the thenar and hypothenar compartments is on the radial side of metacarpal 1<br />
and the ulnar side of metacarpal 5, respectively [89].<br />
Emergency surgery phase – Hand 375
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The indication for fasciotomy on the fingers is made according to clinical criteria. As a pressure<br />
measurement device is not expedient for the fingers, the degree of swelling is used for<br />
establishing the indication for fasciotomy. The incision is made unilaterally, radial for the thumb<br />
and little finger and ulnar for the other fingers. Preference should be given to a mid-lateral<br />
incision line from the fingertip to the interdigital crease. While protecting the neurovascular<br />
bundle, the Cleland ligaments should be divided on both sides in the palmar flexor tendon canal<br />
[89].<br />
Emergency surgery phase – Hand 376
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Achauer BM, [The burned hand]. Operative Hand<br />
Surgery, 1999: p. 2045-2060 [LoE 2a]<br />
2. Aldrian, S., T. Nau, et al., [Hand injury in<br />
polytrauma]. Wien Med Wochenschr, 2005.<br />
155(9-10): p. 227-32 [LoE 4]<br />
3. Arakaki A, Tsai TM, [Thumb replantation:<br />
survival factors and re-exploration in 122 cases].<br />
J Hand Surg, 1993 18(2): p. 152-6 [LoE 2b]<br />
4. Arora, R., M. Lutz, et al., [Dorsolateral<br />
dislocation of the proximal interphalangeal joint:<br />
closed reduction and early active motion or static<br />
splinting; a retrospective study]. Arch Orthop<br />
Trauma Surg, 2004. 124(7): p. 486-8 [LoE 2b]<br />
5. Ashmead D 4th, Rothkopf DM, Walton RL,<br />
Jupiter JB, [Treatment of hand injuries by<br />
external fixation]. J Hand Surg [Am], 1992.<br />
17(5): p. 956-64 [LoE 4]<br />
6. Bache J., [Clinical evaluation of the use of Op-<br />
Site gloves for the treatment of partial thickness<br />
burns of the hand]. Burns Incl Therm Inj, 1988.<br />
14(5): p. 413-6 [LoE 4]<br />
7. Baker GL, Kleinert JM, [Digit replantation in<br />
infants and young children: determinants of<br />
survival]. Plast Reconstr Surg, 1994. 94(1): p.<br />
139-45 [LoE 4]<br />
8. Betancourt FM, Mah ET, McCabe SJ, [Timing of<br />
critical thrombosis after replantation surgery of<br />
the digits]. J Reconstr Microsurg, 1998. 14(5): p.<br />
313-6 [LoE 4]<br />
9. Birch R, Raji AR., [Repair of median and ulnar<br />
nerves. Primary suture is best]. J Bone Joint Surg<br />
Br, 1991. 73(1): p. 154-7 [LoE 2b]<br />
10. Blount WP, [Volkmann's ischemic contracture].<br />
Surg Gynecol Obstet, 1950. 90: p. 244-246 [LoE<br />
5]<br />
11. Bolton H., [Primary tendon repair]. Hand, 1970.<br />
2(1): p. 56-7 [LoE 4]<br />
12. Bongard FS, White GH, Klein SR, [Management<br />
strategy of complex extremity injuries]. Am J<br />
Surg, 1989. 158(2): p. 151-5 [LoE 4]<br />
13. Boulas HJ, [Amputations of the fingers and hand:<br />
indications for replantation]. J Am Acad Orthop<br />
Surg, 1998. 6(2): p. 100-5 [LoE 5]<br />
14. Brcic A., [Primary tangential excision for hand<br />
burns]. Hand Clin, 1990. 6(2): p. 211-9 [LoE 5]<br />
15. Brenner P, Reichert B, Berger A., [Replantation<br />
bei Mehrfachverletzungen]. Handchir Mikrochir<br />
Plast Chir, 1995. 27(1): p. 12-6 [LoE 4]<br />
16. Brown PW, [War wounds of the hand revisited].<br />
J Hand Surg [Am], 1995. 20(3 Pt 2): p. 61-7<br />
[LoE 5]<br />
17. Brown PW, [Open injuries of the hand].<br />
Operative Hand Surgery, 1999: p. 1607-1630<br />
[LoE 2a]<br />
18. Brushart TM, [Nerve repair and grafting].<br />
Operative Hand Surgery, 1999: p. 1381-1403<br />
[LoE 2a]<br />
19. Büchler U., [Traumatic soft-tissue defects of the<br />
extremities. Implications and treatment<br />
guidelines.]. Arch Orthop Trauma Surg, 1990.<br />
109(6): p. 321-9 [Evidenzbasierte Leitlinie]<br />
20. Büchler U, Hastings H, [Combined injuries].<br />
Operative Hand Surgery, 1999: p. 1631-50 [LoE<br />
2a]<br />
21. Chen CT, Wei FC, Chen HC, Chuang CC, Chen<br />
HT, Hsu WM., [Distal phalanx replantation].<br />
Microsurgery, 1994. 15(1): p. 77-82 [LoE 4]<br />
22. Ch<strong>eng</strong> GL, Pan DD, Yang ZX, Fang GR, Gong<br />
XS, [Digital replantation in children]. Ann Plast<br />
Surg, 1985. 15(4): p. 325-31 [LoE 4]<br />
23. Chinchalkar SJ, Gan BS. [Management of<br />
proximal interphalangeal joint fractures and<br />
dislocations]. J Hand Ther, 2003. 16(2): p. 117-<br />
28 [LoE 5]<br />
24. Chiu HY, Shieh SJ, Hsu HY., [Multivariate<br />
analysis of factors influencing the functional<br />
recovery after finger replantation or<br />
revascularization]. Microsurgery, 1995. 16(10):<br />
p. 713-7 [LoE 2b]<br />
25. Coenen L, Boeckx W, Gruwez JA, [The<br />
treatment of flexor tendon lesions of the fingers].<br />
Acta Chir Belg, 1981. 80(4): p. 195-204 [LoE 4]<br />
26. Dellinger EP, Caplan ES, Weaver LD, Wertz MJ,<br />
Droppert BM, Hoyt N, Brumback R, Burgess A,<br />
Poka A, Benirschke SK, et al, [Duration of<br />
preventive antibiotic administration for open<br />
extremity fractures]. Arch Surg, 1988. 123(3): p.<br />
333-9 [LoE 1b]<br />
27. De Medinaceli L, Seaber AV, [Experimental<br />
nerve reconnection: importance of initial repair].<br />
Microsurgery, 1989. 10(1): p. 56-70 [LoE 2b]<br />
28. Demiri E, Bakhach J, Tsakoniatis N, Martin D,<br />
Baudet J, [Bone growth after replantation in<br />
children]. J Reconstr Microsurg, 1995. 11(2): p.<br />
113-23 [LoE 4]<br />
29. Dittel KK, Weller S, [Zur Problematik des<br />
polytraumatisierten Patienten]. Akt Traumatol,<br />
1981. 11: p. 35-42 [LoE 4]<br />
30. Doyle JR, [Extensor tendons – acute injuries].<br />
Operative Hand Surgery, 1999: p. 1950-1987<br />
[LoE 2a]<br />
31. Durham RM, Mistry BM, Mazuski JE, Shapiro<br />
M, Jacobs D, [Outcome and utility of scoring<br />
systems in the management of the mangled<br />
extremity]. Am J Surg, 1996. 172(5): p. 569-74<br />
[LoE 2b]<br />
32. Earley MJ, Watson JS, [Twenty four thumb<br />
replantations]. J Hand Surg [Br], 1984. 9(1): p.<br />
98-102 [LoE 4]<br />
33. Eichler GR, Lipscomb PR, [The changing<br />
treatment of Volkmann's ischemic contractures<br />
from 1955 to 1965 at the Mayo Clinic]. Clin<br />
Orthop, 1967. 50: p. 215-23 [LoE 4]<br />
34. Elton RC, Bouzard WC, [Gunshot and fragment<br />
wounds of the metacarpus]. South Med J, 1975.<br />
68(7): p. 833-43 [LoE 4]<br />
Emergency surgery phase – Hand 377
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
35. Elton RC, Bouzard WC, [Management of<br />
gunshot and fragment wounds of the<br />
metacarpus]. J Bone Joint Surg , 1973. 55A: p.<br />
887 [LoE 4]<br />
36. Fetrow KO, [Diagnosis and management of the<br />
severed flexor tendon of the hand]. Surg Clin<br />
North Am, 1974. 54(4): p. 923-38 [LoE 5]<br />
37. Foucher G, Norris RW, [Distal and very distal<br />
digital replantations]. Br J Plast Surg, 1992.<br />
45(3): p. 199-203 [LoE 4]<br />
38. Freeland AE, [External fixation for skeletal<br />
stabilization of severe open fractures of the<br />
hand]. Clin Orthopm 1987. 214: p. 93-100 [LoE<br />
4]<br />
39. Garcia-Elias M, [Carpal instabilities and<br />
dislocations]. Operative Hand Surgery, 1999: p.<br />
865-928 [LoE 2a]<br />
40. Garcia-Elias M, Irisarri C, Henriquez A, Abanco<br />
J, Fores J, Lluch A, Gilabert A, [Perilunar<br />
dislocation of the carpus. A diagnosis still often<br />
missed]. Ann Chir Main, 1986. 5(4): p. 281-7<br />
[LoE 2b]<br />
41. Gelberman RH, Menon J, Fronek A, [The<br />
peripheral pulse following arterial injury]. J<br />
Trauma, 1980. 20(11): p. 948-51 [LoE 4]<br />
42. Gelberman RH, Zakaib GS, Mubarak SJ,<br />
Hargens AR, Akeson WH, [Decompression of<br />
forearm compartment syndromes]. Clin Orthop,<br />
1978. 134: p. 225-9 [LoE 4]<br />
43. Germann G, Sherman R, Levin LS, [Decisionmaking<br />
in reconstructive surgery: upper<br />
extremity]. 2000 [LoE 2a]<br />
44. Gillespie WJ, Walenkamp G, [Antibiotic<br />
prophylaxis for surgery for proximal femoral and<br />
other closed long bone fractures]. Cochrane<br />
Database Syst Rev, 2001. 1: CD000244 [LoE 1a]<br />
45. Glickel SZ, Barron OA, Eaton RG, [Dislocations<br />
and ligament injuries in the digits]. Operative<br />
Hand Surgery, 1999: p. 772-808 [LoE 2a]<br />
46. Goldner RD, Nunley JA, [Replantation proximal<br />
to the wrist]. Hand Clin, 1992. 8(3): p. 413-25<br />
[LoE 4]<br />
47. Goldner RD, Stevanovic MV, Nunley JA,<br />
Urbaniak JR, [Digital replantation at the level of<br />
the distal interphalangeal joint and the distal<br />
phalanx]. J Hand Surg [Am], 1989. 14(2 Pt 1): p.<br />
214-20 [LoE 4]<br />
48. Goldner RD, Urbaniak JR, Replantation].<br />
Operative Hand Surgery, 1999: p. 1139-1157<br />
[LoE 2a]<br />
49. Gonzalez MH, Jablon M, Weinzweig N, [Open<br />
fractures of the hand]. J South Orthop Assoc,<br />
1999. 8(3): p. 193-202 [LoE 4]<br />
50. Hansbrough JF, Achauer B, Dawson J, Himel H,<br />
Luterman A, Slater H, Levenson S, Salzberg CA,<br />
Hansbrough WB, Doré C, [Wound healing in<br />
partial-thickness burn wounds treated with<br />
collagenase ointment versus silver sulfadiazine<br />
cream]. J Burn Care Rehabil, 1995. 16(3 Pt 1): p.<br />
241-7 [LoE 1b]<br />
51. Hargens AR, Akeson WH, Mubarak SJ, Owen<br />
CA, Gershuni DH, Garfin SR, Lieber RL, Danzig<br />
LA, Botte MJ, Gelberman RH, [Tissue fluid<br />
pressures: from basic research tools to clinical<br />
applications]. J Orthop Res, 1989. 7(6): p. 902-9<br />
[LoE 4]<br />
52. Helfet DL, Howey T, Sanders R, Johansen K,<br />
[Limb salvage versus amputation. Preliminary<br />
results of the Mangled Extremity Severity Score].<br />
Clin Orthop, 1990. 256: p. 80-6 [LoE 2b]<br />
53. Herzberg G, Comtet JJ, Linscheid RL, Amadio<br />
PC, Cooney WP, Stalder J, [Perilunate<br />
dislocations and fracture-dislocations: a<br />
multicenter study]. J Hand Surg [Am], 1993.<br />
18(5): p. 768-79 [LoE 2b]<br />
54. Holden CE, [Compartmental syndromes<br />
following trauma]. Clin Orthop, 1975. 113: p. 95-<br />
102 [LoE 4]<br />
55. Holden CE, [The pathology and prevention of<br />
Volkmann's ischaemic contracture]. J Bone Joint<br />
Surg Br, 1979. 61-B(3): p. 296-300 [LoE 4]<br />
56. Inoue G, Tanaka Y, Nakamura R, [Treatment of<br />
trans-scaphoid perilunate dislocations by internal<br />
fixation with the Herbert screw]. J Hand Surg<br />
[Br], 1990. 15(4): p. 449-54 [LoE 4]<br />
57. Jensen EG, Weilby A, [Primary tendon suture in<br />
the thumb and fingers]. Hand. 1974. 6(3): p. 297-<br />
303 [LoE 4]<br />
58. Kallio PK, Vastamäki M, [An analysis of the<br />
results of late reconstruction of 132 median<br />
nerves]. J Hand Surg [Br], 1993. 18(1): p. 97-105<br />
[LoE 2b]<br />
59. Kallio PK, Vastamäki M, Solonen KA, [The<br />
results of secondary microsurgical repair of radial<br />
nerve in 33 patients]. J Hand Surg [Br], 1993.<br />
18(3): p. 320-2 [LoE 2b]<br />
60. Keller HP, Lanz U, Greulich M, [Replantation of<br />
parts of the distal phalanx without venous<br />
anastomosis]. Handchir Mikrochir Plast Chir.<br />
1984 Mar;16(1): p. 28-30 [LoE 4]<br />
61. Kleinert HE, Kutz JE, Atasoy E, Stormo A,<br />
[Primary repair of flexor tendons]. Orthop Clin<br />
North Am, 1973. 4(4): p. 865-76 [LoE 4]<br />
62. Kleinert HE, Schepel S, Gill T, [Flexor tendon<br />
injuries]. Surg Clin North Am, 1981. 61(2): p.<br />
267-86 [LoE 5]<br />
63. Koman LA, Ruch DS, Smith BP, Smith TL,<br />
[Vascular disorders]. Operative Hand Surgery,<br />
1999: p. 2254-2302 [LoE 2a]<br />
64. Liss FE, Green SM, [Capsular injuries of the<br />
proximal interphalangeal joint]. Hand Clin, 1992.<br />
8(4): p. 755-68 [LoE 4]<br />
65. Lister GD, Kleinert HE, Kutz JE, Atasoy E,<br />
[Primary flexor tendon repair followed by<br />
immediate controlled mobilization]. J Hand Surg<br />
[Am], 1977. 2(6): p. 441-51 [LoE 2b]<br />
66. Lutz M, Reinhart C, Kathrein A, Kralinger F,<br />
Angermann P, Gabl M, Pechlaner S, [Dorsale<br />
Luxation der PIP-Gelenke der Finger. Ergebnisse<br />
nach statischer und nach funktioneller<br />
Emergency surgery phase – Hand 378
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Behandlung]. Handchir Mikrochir Plast Chir,<br />
2001. 33(3): p. 207-10 [LoE 2b]<br />
67. Mahler D, Benmeir P, Ben Yakar Y, Greber B,<br />
Sagi A, Hauben D, Rosenberg L, Sarov B,<br />
[Treatment of the burned hand: early surgical<br />
treatment (1975-85) vs. conservative treatment<br />
(1964-74). A comparative study]. Burns Incl<br />
Therm Inj, 1987. 13(1): p. 45-8 [LoE 2b]<br />
68. Malizos KN, Beris AE, Kabani CT, Korobilias<br />
AB, Mavrodontidis AN, Soucacos PN, [Distal<br />
phalanx microsurgical replantation].<br />
Microsurgery, 1994. 15(7): p. 464-8 [LoE 4]<br />
69. Mark G, [Das Schicksal des polytraumatisierten<br />
Patienten mit einer "Bagatellverletzung" an der<br />
Hand]. Handchir Mikrochir Plast Chir, 1989 .<br />
21(1): p. 51-4 [LoE 5]<br />
70. Marsh D, Barton N, [Does the use of the<br />
operating microscope improve the results of<br />
peripheral nerve suture?]. J Bone Joint Surg Br,<br />
1987. 69(4): p. 625-30 [LoE 2b]<br />
71. Mass<strong>eng</strong>ill JB, [Primary and delayed repairs of<br />
flexor tendons in "no man's land": 18 consecutive<br />
cases]. J Med Soc N J, 1978. 75: p. 307-310 [LoE<br />
4]<br />
72. Mass<strong>eng</strong>ill JB, [Treatment of skin loss in the<br />
hand]. Orthop Rev, 1987. 16(6): p. 386-93 [LoE<br />
5]<br />
73. McQueen MM, Court-Brown CM, [Compartment<br />
monitoring in tibial fractures. The pressure<br />
threshold for decompression]. J Bone Joint Surg<br />
Br, 1996. 78(1): p. 99-104 [LoE 2b]<br />
74. Minami A, Kaneda K, [Repair and/or<br />
reconstruction of scapholunate interosseous<br />
ligament in lunate and perilunate dislocations]. J<br />
Hand Surg [Am], 1993. 18(6): p. 1099-1106<br />
[LoE 2b]<br />
75. Minami A, Ogino T, Ohshio I, Minami M,<br />
[Correlation between clinical results and carpal<br />
instabilities in patients after reduction of lunate<br />
and perilunar dislocations]. J Hand Surg [Br],<br />
1986. 11(2): p. 213-20 [LoE 4]<br />
76. Moore MN, [Orthopedic pitfalls in emergency<br />
medicine]. South Med J, 1988. 81(3): p. 371-8<br />
[LoE 5]<br />
77. Mubarak SJ, Hargens AR, [Acute compartment<br />
syndromes]. Surg Clin North Am, 1983. 63(3): p.<br />
539-65 [LoE 5]<br />
78. Nast-Kolb D, Keßler S, Duswald KH, Betz A,<br />
Schweiberer L, [Extremtitätenverletzungen<br />
polytraumatisierter Patienten: stuf<strong>eng</strong>erechte<br />
Behandlung]. Unfallchirurg, 1986. 89: p. 149-154<br />
[LoE 4]<br />
79. Ortiz JA Jr, Berger RA, [Compartment syndrome<br />
of the hand and wrist]. Hand Clin, 1998. 14(3): p.<br />
405-18 [LoE 2a]<br />
80. Partington MT, Lineaweaver WC, O'Hara M,<br />
Kitzmiller J, Valauri FA, Oliva A, Buncke GM,<br />
Alpert BS, Siko PP, Buncke HJ, [Unrecognized<br />
injuries in patients referred for emergency<br />
microsurgery]. J Trauma, 1993. 34: p. 238-241<br />
[LoE 4]<br />
81. Peimer CA, Smith RJ, Leffert RD, [Distractionfixation<br />
in the primary treatment of metacarpal<br />
bone loss]. J Hand Surg [Am], 1981. 6(2): p. 111-<br />
24 [LoE 4]<br />
82. Raskin KB, Weiland AJ, [Current concepts of<br />
replantation]. Ann Acad Med Singapore, 1995.<br />
24(4 Suppl): p. 131-4 [LoE 5]<br />
83. Rawlings ID, [The management of dislocations<br />
of the carpal lunate]. Injury, 1981. 12(4): p. 319-<br />
30 [LoE 2b]<br />
84. Regel G, Seekamp A, Takacs J, Bauch S, Sturm<br />
JA, Tscherne H, [Rehabilitation und<br />
Reintregration polytraumatisierter Patienten].<br />
Unfallchirurg, 1993. 96: p. 341-349 [LoE 4]<br />
85. Renaud B, Langlais F, Colmar M, Thomazeau H,<br />
[Digital reimplantations and revascularizations.<br />
Preservation factors (based on 183 fingers)]. Ann<br />
Chir Main Memb Super, 1991. 10(5): p. 385-98<br />
[LoE 4]<br />
86. Renner A, Cserkuti F, Hankiss J, [Spätergebnisse<br />
nach Nerventransplantation an der oberen<br />
Extremität]. Handchir Mikrochir Plast Chir,<br />
2004. 36: p. 13-18 [LoE 2b]<br />
87. Reynolds BM, Balsano NA, Reynolds FX, [Fall<br />
from heights: A surgical experience of 200<br />
consecutive cases]. Ann Surg, 1971. 174: p. 304-<br />
308 [LoE 4]<br />
88. Rothkopf DM, Chu B, Gonzalez F, Borah G,<br />
Ashmead D 4th, Dunn R, [Radial and ulnar artery<br />
repairs: assessing patency rates with color<br />
Doppler ultrasonographic imaging]. J Hand Surg<br />
[Am], 1993. 18(4): p. 626-8 [LoE 4]<br />
89. Rowland SA, [Fasciotomy: The treatment of<br />
compartment syndrome]. Operative Hand<br />
Surgery, 1999: p. 689-710 [LoE 2a]<br />
90. Saies AD, Urbaniak JR, Nunley JA, Taras JS,<br />
Goldner RD, Fitch RD, [Results after replantation<br />
and revascularization in the upper extremity in<br />
children]. J Bone Joint Surg Am, 1994. 76(12): p.<br />
1766-76 [LoE 2b]<br />
91. Schaller P, Geldmacher J, [Die Handverletzung<br />
beim <strong>Polytrauma</strong>. Eine retrospektive Studie an<br />
728 Fällen]. Handchir Mikrochir Plast Chir,<br />
1994. 26: p. 307-312 [LoE 4]<br />
92. Schlenker JD, Kleinert HE, Tsai TM, [Methods<br />
and results of replantation following traumatic<br />
amputation of the thumb in sixty-four patients]. J<br />
Hand Surg [Am], 1980. 5(1): p. 63-70 [LoE 2b]<br />
93. Schrank C, Mayr M, Overesch M, Molnar J,<br />
Henkel V Donnersmarck G, Mühlbauer W,<br />
Ninkovic M. [Results of vacuum therapy (v. a.C.)<br />
of superficial and deep dermal burns]. Zentralbl<br />
Chir, 2004. 129(Suppl 1): p. 59-61 [LoE 4]<br />
94. Schwarze H, Küntscher M, Uhlig C, Hierlemann<br />
H, Prantl L, Ottomann C, Hartmann B,<br />
[Suprathel, a new skin substitute, in the<br />
management of partial-thickness burn wounds:<br />
results of a clinical study]. Ann Plast Surg, 2008.<br />
60(2): p. 181-5 [LoE 1b]<br />
95. Skroudies B, Wening VJ, Jungbluth KH,<br />
[Perilunäre Luxationen und Luxationsfrakturen<br />
Emergency surgery phase – Hand 379
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
beim <strong>Polytrauma</strong>tisierten – Diagnostik und<br />
Therapie]. Unfallchirurgie, 1989. 15: p. 236-242<br />
[LoE 4]<br />
96. Slauterbeck JR, Britton C, Moneim MS,<br />
Clev<strong>eng</strong>er FW, [[Mangled extremity severity<br />
score: an accurate guide to treatment of the<br />
severely injured upper extremity]. J Orthop<br />
Trauma, 1994. 8(4): p. 282-5 [LoE 2b]<br />
97. Sloan JP, Dove AF, Maheson M, Cope AN,<br />
Welsh KR, [Antibiotics in open fractures of the<br />
distal phalanx?]. J Hand Surg [Br], 1987. 12(1):<br />
p. 123-4 [LoE 1b]<br />
98. Smith DJ, McHugh TP, Phillips LG, Robson MC,<br />
Heggers JP, [Biosynthetic compound dressings-management<br />
of hand burns]. Burns Incl Therm<br />
Inj, 1988. 14(5): p. 405-8 [LoE 2b]<br />
99. Soelberg M, Gebuhr P, Klareskov B,<br />
[Interphalangeal dislocations of the fingers<br />
treated by an elastic double-finger bandage]. J<br />
Hand Surg [Br], 1990. 15(1): p. 66-7 [LoE 4]<br />
100. Soucacos PN, Beris AE, Touliatos AS,<br />
Korobilias AB, Gelalis J, Sakas G, [omplete<br />
versus incomplete nonviable amputations of the<br />
thumb. Comparison of the survival rate and<br />
functional results]. Acta Orthop Scand Suppl,<br />
1995. 264: p. 16-8 [LoE 2b]<br />
101. Spier W, [Die Handverletzung bei<br />
Mehrfachverletzten]. Med Welt, 1971. 22: p.<br />
169-172 [LoE 4]<br />
102. Steinberg DR, [Acute flexor tendon injuries].<br />
Orthop Clin North Am, 1992. 23(1): p. 125-40<br />
[LoE 4]<br />
103. Stern PJ, [Fractures of the metacarpals and<br />
phalanges]. Operative Hand Surgery, 1999: p.<br />
711-71 [LoE 2a]<br />
104. Stone JF, Davidson JS, [The role of antibiotics<br />
and timing of repair in flexor tendon injuries of<br />
the hand]. Ann Plast Surg, 1998. 40(1): p. 7-13<br />
[LoE 2b]<br />
105. Straub G, Orthner E, [Die konservative<br />
Behandlung stabiler Mittelgelenkluxationen mit<br />
der Stack'schen Schiene]. Handchir Mikrochir<br />
Plast Chir, 1996. 28(5): p. 246-8 [LoE 4]<br />
106. Strickland, JW., [Delayed treatment of flexor<br />
tendon injuries including grafting]. Hand Clin,<br />
2005. 21(2): p. 219-43 [LoE 2a]<br />
107. Strickland JW., [Flexor tendon injuries. Part 2.<br />
Flexor tendon repair]. Orthop Rev, 1986. 15(11):<br />
p. 701-21 [LoE 4]<br />
108. Strickland JW., [Flexor tendon repair]. Hand<br />
Clin, 1985. 1(1): p. 55-68 [LoE 4]<br />
109. Strickland JW., [Flexor tendon surgery. Part 1:<br />
Primary flexor tendon repair]. J Hand Surg [Br],<br />
1989. 14(3): p. 261-72 [LoE 4]<br />
110. Strickland JW., [Management of acute flexor<br />
tendon injuries]. Orthop Clin North Am, 1983.<br />
14(4): p. 827-49 [LoE 4]<br />
111. Südkamp N, Haas N, Flory PJ, Tscherne H,<br />
Berger A, [Kriterien der Amputation,<br />
Rekonstruktion und Replantation von<br />
Extremitäten bei Mehrfachverletzten]. Chirurg,<br />
1989. 60(11): p. 774-81 [LoE 5]<br />
112. Suprock MD, Hood JM, Lubahn JD, [Role of<br />
antibiotics in open fractures of the finger]. J Hand<br />
Surg [Am], 1990. 15(5): p. 761-4 [LoE 1b]<br />
113. Suzuki K, Matsuda M, [Digital replantations<br />
distal to the distal interphalangeal joint]. J<br />
Reconstr Microsurg, 1987. 3(4): p. 291-5 [LoE 4]<br />
114. Swanson TV, Szabo RM, Anderson DD, [Open<br />
hand fractures: prognosis and classification]. J<br />
Hand Surg [Am], 1991. 16(1): p. 101-7 [LoE 2b]<br />
115. Tang JB, [Flexor tendon repair in zone 2C]. J<br />
Hand Surg [Br], 1994. 19(1): p. 72-5 [LoE 1b]<br />
116. Taras JS, Nunley JA, Urbaniak JR, Goldner RD,<br />
Fitch RD, [Replantation in children].<br />
Microsurgery, 1991. 12(3): p. 216-20 [LoE 4]<br />
117. Terrill PJ, Kedwards SM, Lawrence JC, [The use<br />
of GORE-TEX bags for hand burns]. Burns,<br />
1991. 17(2): p. 161-5 [LoE 1b]<br />
118. Tobin GR, [Closure of contaminated wounds.<br />
Biologic and technical considerations]. Surg Clin<br />
North Am. 1984. 64(4): p. 639-52 [LoE 5]<br />
119. Tscherne H, Regel G, Sturm JA, Friedl HP,<br />
[Schweregrad und Prioritäten bei<br />
Mehrfachverletzungen]. Chirurg, 1987. 58: p.<br />
631-640<br />
120. Urbaniak JR, Roth JH, Nunley JA, Goldner RD,<br />
Koman LA, [The results of replantation after<br />
amputation of a single finger]. J Bone Joint Surg<br />
Am, 1985. 67(4): p. 611-9 [LoE 2b]<br />
121. Van Adrichem LN, Hovius SE, van Strik R, van<br />
der Meulen JC, [The acute effect of cigarette<br />
smoking on the microcirculation of a replanted<br />
digit]. J Hand Surg [Am], 1992. 17(2): p. 230-4<br />
[LoE 2b]<br />
122. Vastamäki M, Kallio PK, Solonen KA, [The<br />
results of secondary microsurgical repair of ulnar<br />
nerve injury]. J Hand Surg [Br], 1993. 18(3): p.<br />
323-6 [LoE 2b]<br />
123. Verdan CE, [Practical considerations for primary<br />
and secondary repair in flexor tendon injuries].<br />
Surg Clin North Am, 1964. 44: p. 951-970 [LoE<br />
4]<br />
124. Verdan CE, [Primary and secondary repair of<br />
flexor and extensor tendon injuries]. Hand<br />
Surgery, 1975: p. 144-166 [LoE 2a]<br />
125. Verdan CE, [Primary repair of flexor tendons]. J<br />
Bone Joint Surg, 1960. 42-A: p. 647-57 [LoE 4]<br />
126. Vicar AJ, [Proximal interphalangeal joint<br />
dislocations without fractures]. Hand Clin, 1988.<br />
4(1): p. 5-13 [LoE 5]<br />
127. Vloemans AF, Soesman AM, Suijker M, Kreis<br />
RW, Middelkoop E, [A randomised clinical trial<br />
comparing a hydrocolloid-derived dressing and<br />
glycerol preserved allograft skin in the<br />
management of partial thickness burns]. Burns,<br />
2003. 29(7): p. 702-10 [LoE 1b]<br />
128. Vossoughi, F., B. Krantz, et al, [Hand injuries as<br />
an indicator of other associated severe injuries].<br />
Am Surg, 2007. 73(7): p. 706-8 [LoE 4]<br />
Emergency surgery phase – Hand 380
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
129. Waikakul S, Vanadurongwan V, Unnanuntana A,<br />
[Prognostic factors for major limb reimplantation<br />
at both immediate and long-term<br />
follow-up]. J Bone Joint Surg Br, 1998. 80(6): p.<br />
1024-30 [LoE 2b]<br />
130. Ward WA, Tsai TM, Breidenbach W, [Per<br />
Primam thumb replantation for all patients with<br />
traumatic amputations]. Clin Orthop, 1991. 266:<br />
p. 90-5 [LoE 2b]<br />
131. Wehner W, [Mittelhand- und Fingerfrakturen bei<br />
Mehrfachschwerverletzten]. Hefte Unfallheilkd,<br />
1980. 141: p. 59-64 [LoE 5]<br />
132. Welkerling H, Wening JV, Langendorff HU,<br />
Jungbluth KH, [Computergestützte Datenanalyse<br />
von Verletzten des knöchernen<br />
Bewegungsapparates beim polytraumatisierten<br />
Patienten]. Zbl Chir, 1991. 116: p. 1263-1272<br />
[LoE 4]<br />
133. Whitesides TE, Heckman MM, [Acute<br />
Compartment Syndrome: Update on Diagnosis<br />
and Treatment]. J Am Acad Orthop Surg, 1996.<br />
4(4): p. 209-218 [LoE 5]<br />
134. Wolff G, Dittmann M, Frede KD, [Klinische<br />
Versorgung des <strong>Polytrauma</strong>tisierten:<br />
Indikationsprioritäten und Therapieplan].<br />
Chirurg, 1978. 49: p. 737-744 [LoE 4]<br />
135. Zhong-Wei C, Meyer VE, Kleinert HE, Beasley<br />
RW, [Present indications and contraindications<br />
for replantation as reflected by long-term<br />
functional results]. Orthop Clin North Am, 1981.<br />
12: p. 849-70 [LoE 5]<br />
136. Zuker RM, Stevenson JH, [Proximal upper limb<br />
replantation in children]. J Trauma, 1988. 28(4):<br />
p. 544-7 [LoE 4]<br />
Emergency surgery phase – Hand 381
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.10 Lower extremity<br />
Key recommendations:<br />
In polytrauma among adults, isolated and multiple shaft fractures of long<br />
bones in the lower extremity can be managed both with primary definitive as<br />
well as primary temporary and secondary definitive osteosynthesis.<br />
As an exception, isolated closed shaft fractures of the tibia can also receive<br />
primary temporary stabilization with a plaster cast.<br />
Explanation:<br />
GoR 0<br />
GoR 0<br />
There are 2 contradictory treatment strategies for isolated shaft fractures of the long bones in the<br />
lower extremities: a) primary definitive osteosynthesis and b) the two-step osteosynthesis with<br />
secondary definitive management. Out of 65 controlled studies published on the femoral shaft<br />
fracture in polytrauma (from 1964 through 2008; with n = 18 to n = 1582 documented patients),<br />
there were 10 studies with prospective or randomized study design. However, the majority of<br />
papers were based on retrospective-clinical data. In addition to the main endpoint of case fatality<br />
rate, there were numerous subsidiary endpoints: complication rates (from pseudarthrosis rate to<br />
incidence of sepsis and organ failure), number of days in situ in the intensive care unit,<br />
ventilation parameters, cardiopulmonary changes, and l<strong>eng</strong>th of stay in hospital. Only a few<br />
authors substantiated their treatment regimens with prospectively collected laboratory chemical<br />
findings. No paper focused on the later quality of life of the patient in the decision criteria. A late<br />
management of long bones was preferred in 20 papers whereas 37 publications regarded early<br />
management as better. Eight authors were undecided. In addition, many authors emphasized that<br />
there are certain patient groups (patients with chest and/or brain injuries) in which a method is<br />
specifically indicated or contraindicated. Specific controlled studies on the isolated lower leg<br />
fracture management strategy in polytrauma were not identified. In summary, it must be stated<br />
that the results of the literature analysis on isolated upper and lower leg shaft fractures are<br />
contradictory and do not permit any generally valid conclusion.<br />
To date, there have been few scientific studies on the management strategy for multiple femur<br />
and lower leg shaft fractures in multiply injured patients. Although the alleged incidence of<br />
multiple femur and lower leg shaft fractures of 2-7% is suggestive of its clinical importance,<br />
there are few references to this in the literature. There was only 1 study with a prospective design<br />
(8 patients) out of 72 papers listed in the databases (MEDLINE, The Cochrane Library, and<br />
Knowledge Finder, as at 1/2004) on the research question of the surgical strategy for bilateral<br />
fracture of the lower extremity. The majority of papers were based on retrospective-clinical data<br />
(n = 42, 4–222 patients) and also case reports (n = 29). In addition to the main endpoint of case<br />
fatality rate, there were numerous subsidiary endpoints such as complication rates, number of<br />
days in situ, and concomitant injuries. The vast majority of authors see the advantages of early<br />
stabilization of fractures but the procedure and timing still remain under dispute. The high<br />
proportion of pulmonary complications in the group of multiple medullary nailing (8.2% versus<br />
Emergency surgery phase – Lower extremity 382
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
62.5%) was noticeable in the only prospective study to date [206]. As a consequence of the<br />
results of this paper, the author recommends a multi-step management strategy. In their<br />
retrospectively collected data, other authors were unable to document any increased pulmonary<br />
risk such as that of (fat) lung embolism following multiple medullary nailings. On the other<br />
hand, others revealed a shortened convalescence and lower complication rate in surgically<br />
stabilized (pediatric) patients and advocate primary definitive stabilization. In summary, surgical<br />
stabilization is increasingly favored in the literature but the type and timing of surgical<br />
stabilization still remains a matter of controversy; a generally-valid conclusion cannot be made.<br />
Within the context of polytrauma management, both isolated and multiple fractures of long<br />
bones of the lower extremity involve a clinically relevant research question which often has to be<br />
decided in everyday practice. Thus, there is an urgent necessity for additional prospective studies<br />
with appropriate study design to clarify the treatment strategy.<br />
Please refer to the introductory section of the emergency surgery phase for the risk assessment<br />
(damage control) of a multiply injured patient as a decision aid in the fracture management<br />
strategy.<br />
Key recommendations:<br />
Proximal femoral fractures in polytrauma can be stabilized by primary<br />
osteosynthesis.<br />
GoR 0<br />
In justified cases, a temporary joint-bridging external fixator can be indicated. GoR 0<br />
Explanation:<br />
There are no controlled studies on the treatment of the proximal femoral fracture specifically in<br />
multiply injured patients. Studies cited below contain both patients with isolated femoral fracture<br />
and multiply injured patients with proximal femoral fracture [37, 103, 104]. Proximal femoral<br />
fractures are subdivided according to their location into intracapsular, extracapsular<br />
(trochanteric), and subtrochanteric fractures.<br />
Femoral head fractures (Pipkin fractures) are rare and often associated with hip dislocations<br />
and/or acetabular fractures. Surgical management ranges from removal of small osteochondral<br />
fragments to refixation and reconstruction of the femoral head. Although femoral neck fractures<br />
are common in elderly people after relatively trivial trauma, in young people they are mostly<br />
caused by a high energy trauma which is often associated with additional multiple injuries. The<br />
favored head salvage procedure is (cannulated) screw osteosynthesis [12, 93, 131, 133–135].<br />
Prosthetic management is listed as equivalent [86, 133-135, 140, 152, 188]. In the meta-analyses<br />
conducted by Bhandari et al. [13] and Parker et al. [132, 136, 137], the osteosynthetic<br />
management of the isolated femoral neck fracture led to a considerably higher revision rate but<br />
the infection rate, blood loss, operating time, and trend in mortality [13] were higher in the group<br />
with joint replacement. To date, no advantage has been found for the bipolar prosthesis<br />
compared to total hip replacement [34, 39, 132, 136, 137].<br />
Emergency surgery phase – Lower extremity 383
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
The extracapsular fracture can be managed with extramedullary, fixed plate sliding hip screw<br />
(dynamic hip screw, Medoff sliding plate, etc.) or intramedullary procedure (proximal femur<br />
nail, gamma nail, etc.) [9, 29, 30, 38, 52, 65, 72, 73, 89, 99, 100, 102, 122, 130, 132–137, 139,<br />
144, 194]. In general, surgical management of the proximal femoral fracture is regarded as the<br />
standard treatment [9, 24, 43, 54, 64, 101, 132, 136–138, 199].<br />
There is no evidence in randomized studies on the timing of fracture management, and<br />
observational studies lead to differing conclusions [23, 45, 71, 138, 191]. Early surgical<br />
management (within 24-36 hours) after physiologic stabilization is recommended for most<br />
patients. The unnecessary delay in operating can increase the complication rate (decubitus rate,<br />
pneumonia). Emergency indications for surgery are: open fracture; fracture with vascular injury;<br />
fracture with compartment syndrome. If surgery has to be significantly delayed (> 48 hours), a<br />
joint-bridging external fixator can be temporarily (or, if applicable, permanently) attached.<br />
Complication possibilities: bleeding, infection, wound healing disorder, avascular necrosis in the<br />
femoral head, pseudarthrosis, rotational malposition, mobility restriction, prosthesis dislocation,<br />
thrombosis, embolism [128].<br />
Please refer to the introductory section of the emergency surgery phase for the risk assessment<br />
(damage control) of a multiply injured patient as a decision aid in the fracture management<br />
strategy.<br />
Key recommendations:<br />
For definitive management of a femoral shaft fracture in multiply injured<br />
patients, the first-line choice of surgical procedure should be locking<br />
medullary nailing.<br />
Explanation:<br />
GoR B<br />
Surgical stabilization of the femoral shaft fracture is regarded as the standard treatment (see Key<br />
Recommendation 1). Emergency indications for surgery are: open fracture; fracture with<br />
vascular injury; fracture with compartment syndrome. In a hemodynamically stable situation (see<br />
“Emergency room management”), the focus is on early definitive osteosynthesis with the<br />
intramedullary nail being preferred by most authors as the gold standard [27, 33, 96, 198]. The<br />
central argument of the proponents of the medullary nail is the early weight-bearing capacity.<br />
Nevertheless, in a retrospective study on 255 multiply injured patients with femoral fracture,<br />
Neudeck et al. [119] showed that, taking account of injury severity, injury pattern, and clinical<br />
course, only 29% of these patients could benefit from the advantage of early weight-bearing<br />
capacity after primary medullary nailing. Thus, the choice of primary surgical procedure (nailing<br />
versus plate osteosynthesis) in the multiply injured patient is also treated as a matter for debate<br />
by a few authors [6, 18, 20, 83, 90, 126, 159, 168, 174]. Bone et al. [18] showed that the<br />
incidence of pulmonary complications does not depend on the type of stabilization (nail/plate) of<br />
the femoral fracture but is solely caused by the lung injury. In a retrospective study on 217<br />
patients with drilled femur nailing and 206 patients with plate osteosynthesis, Bosse et al. [20]<br />
Emergency surgery phase – Lower extremity 384
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
likewise found no differences in the incidence of lung failure (ARDS) in multiply injured<br />
patients with and without chest trauma. In a retrospective study for primary plate osteosynthesis,<br />
Auf´m Kolk et al. [6] also found evidence of no increase in case fatality rate and morbidity in<br />
patients with and without chest trauma (AIS thorax ≥ 3). In support of this, several animal<br />
models, including one by Wozasek et al. [200], found evidence of no significant pulmonaryhemodynamic<br />
effect between medullary nailing and plate osteosynthesis. There is no dispute<br />
surrounding the issue of fat embolization due to elevated intramedullary pressure as a result of<br />
medullary nailing, and there is evidence of this, particularly by echocardiography, in many<br />
clinical and animal experimental studies [145]. Ultimately, the question of clinical relevance still<br />
remains unclarified and thus also the question whether preference should be given to (non)drilled<br />
medullary nailing. Accordingly, several prospective randomized studies comparing drilled and<br />
nondrilled medullary nailing found evidence of no differences in the ARDS rate, pulmonary<br />
complications, and the survival rate [5, 35].<br />
Open grade 3 femoral fractures with vascular involvement are regarded as contraindications of<br />
primary medullary nailing in hemodynamically stable patients [51, 119, 182]. In these cases,<br />
alternative procedures such as the external fixator are used as a type of stabilization [166].<br />
Femoral shaft fractures are characterized by good callus formation and a low complication rate<br />
[26]. Ten to twenty percent of femoral shaft fractures are associated with ligamentous injuries in<br />
the knee joint. Complication possibilities are: bleeding, infection, wound healing disorder,<br />
avascular necrosis in the femoral head, pseudarthrosis, rotational malposition, mobility<br />
restriction, thrombosis, embolism.<br />
Please refer to the introductory section of the emergency surgery phase for the risk assessment<br />
(damage control) of a multiply injured patient as a decision aid in the fracture management<br />
strategy.<br />
Emergency surgery phase – Lower extremity 385
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
Unstable distal femoral fractures in polytrauma can be stabilized by primary<br />
surgery.<br />
Explanation:<br />
GoR 0<br />
There are no controlled studies on the treatment of the distal femoral fracture specifically in<br />
polytrauma. Studies cited below contain both patients with isolated femoral fracture and multiply<br />
injured patients with distal femoral fracture. Surgical management of the distal femoral fracture<br />
is regarded as the standard treatment. Emergency indications for surgery are: open fracture;<br />
fracture with vascular injury; fracture with compartment syndrome. In a hemodynamically stable<br />
situation, the focus is on early definitive osteosynthesis. Depending on the fracture type, both<br />
intra-articular fractures and fractures without intra-articular involvement of the distal femur can<br />
be managed by open or closed reduction and osteosynthesis by means of a plate (Less Invasive<br />
Stabilization System [LISS], angled plate, etc.) or retrograde nailing [67, 79, 88, 125, 169, 179,<br />
207]. A joint-bridging external fixator can be temporarily attached in a hemodynamically<br />
unstable situation or as part of a damage control strategy.<br />
Complication possibilities: bleeding, infection, wound healing disorder, pseudarthrosis,<br />
rotational malposition, mobility restriction, thrombosis, embolism, early arthrosis.<br />
Please refer to the introductory section of the emergency surgery phase for the risk assessment<br />
(damage control) of a multiply injured patient as a decision aid in the fracture management<br />
strategy.<br />
Key recommendations:<br />
Knee dislocations must be reduced at the earliest possible opportunity. GoR A<br />
Knee dislocations must be stabilized at the earliest possible opportunity. GoR B<br />
Explanation:<br />
There are no controlled studies on the treatment of knee dislocation specifically in polytrauma.<br />
Studies cited below contain both patients with isolated knee dislocation and multiply injured<br />
patients with knee dislocation. The highest management priority is given to any vascular injury<br />
(popliteal artery), which must be treated. The study by Green and Allen [56] with 245 patients<br />
with knee dislocation showed a vascular injury in 32% of cases. In 86% of patients who received<br />
vascular reconstruction beyond the 8-hour period, an amputation had to be performed; 2/3 of the<br />
remaining patients retained an ischemic contracture. Compartment release is recommended if the<br />
ischemia period exceeds the 6-hour limit and if there is a threat of compartment syndrome.<br />
Emergency surgery phase – Lower extremity 386
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
In the hemodynamically stable and unstable multiply injured patient, the knee dislocation should<br />
be reduced at the earliest possible opportunity. If closed reduction is not successful, the<br />
dislocated joint is open reduced [77]. In planned conservative treatment and in planned early<br />
cruciate ligament reconstruction, the stabilization of the reduction result can be carried out by<br />
means of external fixator and transfixation with Steinmann nail or with brace/plaster. According<br />
to expert opinion, the external fixator reveals advantages over other methods [91].<br />
Ligamentous injuries after knee dislocation can be treated by surgery or conservatively. The<br />
meta-analysis by Dedmond and Almekinders [40] studied the results from 12 retrospective and 3<br />
prospective studies on 132 surgically treated and 74 conservatively treated knee dislocations<br />
with respect to the clinical outcome. The surgically managed patients showed significantly better<br />
results in range of motion (123 ° versus 108 °), in the Lysholm score (85.2 versus 66.5), and a<br />
reduced flexion contracture (0.5 ° versus 3.5 °). Randomization of the treatment groups did not<br />
take place and the indication for surgical or conservative procedure is not substantiated. Two<br />
more retrospective studies also showed superiority in surgical compared to non-surgical<br />
treatment [113, 158].<br />
Direct suture or cruciate ligament replacement is available for the surgical management of<br />
cruciate ligaments after knee dislocation. Regarding stability and range of motion, the<br />
retrospective study by Mariani et al. [105] with a small number of cases of knee dislocations<br />
showed superiority in anterior and posterior cruciate ligament reconstruction with patellar tendon<br />
or semitendinosus tendon compared to direct suture [105].<br />
Key recommendation:<br />
Unstable proximal tibial fractures and tibial head fractures can undergo<br />
primary stabilization.<br />
Explanation:<br />
GoR 0<br />
There are no controlled studies on the treatment of proximal tibial fracture specifically in<br />
polytrauma. Studies cited below contain both patients with isolated proximal tibial fracture and<br />
multiply injured patients with proximal tibial fracture.<br />
Primary management can be carried out by splint immobilization. Non-dislocated fractures are<br />
conservatively treated by decompression and functional treatment. If necessary, surgical fixation<br />
can be performed to prevent secondary dislocation. Surgical management of the dislocated<br />
proximal tibial fracture is regarded as the standard treatment [75, 114]. Rival procedures are<br />
plate systems (conventional, fixed-angle Less Invasive Stabilization System – LISS, etc.), tibia<br />
nails, screws, and fixator systems [10, 84, 121, 153], which are used depending on the<br />
complexity and joint surface involvement of the fracture. Requirements of osteosynthesis are the<br />
option for joint surface reconstruction and permanent fracture stabilization along with<br />
mobilization treatment while minimizing the perioperative soft tissue damage. In the case of<br />
minor dislocation, arthroscopically assisted, radiologically controlled reduction and percutaneous<br />
screw fixing can be carried out [58]. Emergency indications for surgery are: open fracture;<br />
Emergency surgery phase – Lower extremity 387
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
fracture with vascular injury; fracture with compartment syndrome. If necessary, an external<br />
fixator can be attached until the soft tissue conditions permit definitive management. In the<br />
hemodynamically stable situation, the focus is on early definitive elective osteosynthesis after<br />
initial subsidence in swelling (e.g., after 3-5 days). Tibial plateau fractures are associated with<br />
meniscus injuries in up to 50% of cases and with ligamentous injuries in up to 25% of cases [11].<br />
Complication possibilities [205]: bleeding, infection, wound healing disorder, pseudarthrosis,<br />
rotational malalignment, mobility restriction, thrombosis, embolism, early arthrosis.<br />
Please refer to the introductory section of the emergency surgery phase for the risk assessment<br />
(damage control) of a multiply injured patient as a decision aid in the fracture management<br />
strategy.<br />
Key recommendation:<br />
Tibial shaft fractures should undergo surgical stabilization. GoR B<br />
Explanation:<br />
There are no controlled studies on the best management procedure specifically for a tibial shaft<br />
fracture occurring in polytrauma. The core requirement is adapted management in relation to the<br />
overall condition. Due to the marginal soft tissue situation in the distal half of the tibia, the<br />
treatment strategy is often not dictated by the fracture per se but by the existing soft tissue<br />
situation.<br />
Stable fractures with minimum dislocation can be conservatively treated with plaster<br />
immobilization [164]. Surgical management of the unstable tibial shaft fracture is regarded as the<br />
standard treatment, usually by intramedullary nailing [159, 197, 201]. Emergency indications for<br />
surgery are: open fracture; fracture with vascular injury; fracture with compartment syndrome. In<br />
a hemodynamically stable situation, the focus is on early definitive osteosynthesis. If surgery has<br />
to be significantly delayed (> 48 hours) or there is an extensive open injury with severe<br />
contamination, an external fixator can be temporarily (or if necessary permanently) attached<br />
[80].<br />
In a meta-analysis by Bhandari et al. [15], the treatment of open tibial shaft fractures was<br />
studied. The results showed that, compared to the external fixator, non-drilled medullary nails<br />
reduced the risk of re-operation, pseudarthrosis, and superficial infection. A smaller re-operation<br />
risk was revealed with drilled nails in comparison with non-drilled nails. In a prospective<br />
randomized study, evidence was also found in closed fractures of a lower rate of secondary<br />
operations and pseudarthroses after a drilled medullary nail compared to a non-drilled medullary<br />
nail [94]. Tibial shaft fractures are associated with ligamentous injuries in up to 22% of cases.<br />
Complication possibilities: bleeding, infection, wound healing disorder, soft tissue necrosis with<br />
the necessity of a skin graft (dermatoplasty), pseudarthrosis, rotational malalignment, mobility<br />
restriction, thrombosis, embolism. Please refer to the introductory section of the emergency<br />
Emergency surgery phase – Lower extremity 388
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
surgery phase for the risk assessment (damage control) of a multiply injured patient as a decision<br />
aid in the fracture management strategy.<br />
Key recommendation:<br />
Distal lower leg fractures including articular distal tibial fractures should<br />
undergo surgical stabilization.<br />
Explanation:<br />
GoR B<br />
There are no controlled studies on the isolated treatment of the distal tibial fracture specifically<br />
in polytrauma. Studies cited below contain both patients with isolated distal tibial fracture and<br />
multiply injured patients with distal tibial fracture.<br />
Surgical management of the distal tibial fracture is regarded as the standard treatment. Due to the<br />
marginal soft tissue situation in the distal tibia (and in the pilon), the treatment strategy is often<br />
not dictated by the fracture per se but by the existing soft tissue situation. Emergency indications<br />
for surgery are: open fracture; fracture with vascular injury; fracture with compartment<br />
syndrome. In a hemodynamically stable situation, the focus is on early definitive osteosynthesis.<br />
Distal tibial fractures without pilon involvement can be managed by medullary nail<br />
osteosynthesis. In addition to medullary nailing, fixed-angle plate osteosynthesis should be<br />
mentioned as a procedure option, particularly as an inserted plate. In the case of a distal fibular<br />
fracture as well, additional plate osteosynthesis of the fibula is recommended (in order to build a<br />
frame and to prevent distal axial deviation) [19, 41, 63, 97, 151, 155, 176, 186, 195]. In the case<br />
of pilon involvement, open reduction and osteosynthesis are regarded as the standard treatment<br />
[26, 69, 184, 202]. If the operation has to be significantly delayed (> 48 hours) (e.g., if there is<br />
severe swelling or open contamination), a joint-bridging external fixator can also be attached<br />
temporarily (or if necessary permanently), if necessary with percutaneous fixation of the joint<br />
surface (screws, K wires). Complication possibilities are: bleeding, infection, wound healing<br />
disorder, soft tissue necrosis with the necessity of a skin graft (dermatoplasty), pseudarthrosis,<br />
rotational malalignment, mobility restriction, thrombosis, embolism, early arthrosis. Please refer<br />
to the introductory section of the emergency surgery phase for the risk assessment (damage<br />
control) of a multiply injured patient as a decision aid in the fracture management strategy.<br />
Emergency surgery phase – Lower extremity 389
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
Ankle fractures should undergo primary stabilization. GoR B<br />
Explanation:<br />
There are no controlled studies on the isolated treatment of ankle fractures specifically in<br />
polytrauma. Studies cited below contain both patients with isolated ankle fracture and multiply<br />
injured patients with ankle fracture.<br />
Surgical management in general and the type of osteosynthetic management of the fibula fracture<br />
depend not least on the rest of the injury pattern in the multiply injured patient. Thus, some<br />
authors prefer external fixation at an injury severity of ISS > 25 or 29 points and/or with a chest<br />
trauma of AIS > 3 [4, 118, 164]. In addition, the type of fracture determines the choice of<br />
osteosynthesis material.<br />
Proximal fibula: In Maisonneuve injuries, the distal fibula should be surgically fixed to the tibia<br />
in the upper ankle [47]. Here, 2 syndesmotic screws should be attached as, being tricortical, these<br />
screws have 5-fold greater tear and rotational str<strong>eng</strong>th than the sole suture of the syndesmosis<br />
[55, 203].<br />
Fibula shaft: High fibula fractures in terms of a pronation-eversion injury according to Lauge-<br />
Hansen type III or IV should be surgically managed (plate osteosynthesis). The complex<br />
dislocation mechanism may have additionally led to other bony (medial malleolus fractures) and<br />
ligamentous injuries (syndesmoses, medial/lateral capsular ligament apparatus) [157].<br />
Distal fibula: “Stable” and “unstable” fractures must be differentiated between in isolated lateral<br />
malleolus fractures. “Stable” fractures are those at the level of the syndesmosis (Weber B1) and<br />
supination-eversion fractures type SE II according to Lauge-Hansen [25, 44, 156, 204]. A stable<br />
lateral malleolus fracture exists if there is no fibula shortening, no fracture dislocation > 2 mm,<br />
no axis deflection, and an intact posterior syndesmosis [44, 156]. Stable lateral malleolus<br />
fractures can be conservatively immobilized, e.g., in a plaster cast or orthotic device<br />
manufactured from synthetic material. Types of fracture that deviate from this must be surgically<br />
managed.<br />
The type of osteosynthesis also depends on the concomitant soft tissue injury (contusion,<br />
swelling, compartment syndrome) [146]. In the case of relatively severe soft tissue damage or<br />
more complex types of fracture (e.g., dislocation fractures), the first goal must be external<br />
fixation irrespective of the extent of the remaining injuries in order to prevent imminent<br />
neurovascular damage [22]. In the case of stable lateral malleolus fractures and lateral malleolus<br />
fractures that have been made stable by osteosynthesis, a follow-up treatment strategy that<br />
provides early functionality and early weight-bearing capacity shows a significant improvement<br />
in the ankle’s range of motion and requires a shorter rehabilitation phase [148].<br />
Emergency surgery phase – Lower extremity 390
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Please refer to the introductory section of the emergency surgery phase for the risk assessment<br />
(damage control) of a multiply injured patient as a decision aid in the fracture management<br />
strategy.<br />
Key recommendation:<br />
Perioperative antibiotic prophylaxis must be carried out in the surgical<br />
management of both close and open fractures of the lower extremity.<br />
Explanation:<br />
GoR A<br />
In open fractures, there is preoperative bacterial contamination in 48-60% of all wounds and in<br />
100% of all severe wounds [98].<br />
Antibiotic administration in closed fractures:<br />
In the surgical management of closed fractures, the administration of antimicrobial prophylaxis<br />
(normally a single shot of a long-acting first-generation cephalosporin) is generally<br />
recommended when implanting foreign material [3, 78]. There is EL 1 data on the management<br />
of femoral neck fractures which confirm a significant reduction in postoperative wound<br />
infections through perioperative antibiotic treatment [21, 31, 32, 78]. The Cochrane Review of<br />
2003, which analyzes data from 8,307 patients from 22 studies, reveals a significant reduction in<br />
postoperative wound infections as well as also in infections of the genitourinary and respiratory<br />
tracts by preoperative single shot antibiosis during the surgical management of fractures to the<br />
long bones. Both in the Cochrane Review by Gillespie et al. [53] and in the meta-analysis by<br />
Slobogean et al. [173], no evidence could be found of further advantages from multi-dose<br />
compared to single shot antibiosis.<br />
Antibiotic administration in open fractures:<br />
The presence of open fractures provides sufficient evidence that antimicrobial prophylaxis<br />
should be carried out. According to the guideline of EAST (Eastern Association for the Surgery<br />
of Trauma), in addition to careful wound debridement - if possible within 6 hours of the trauma -<br />
it is recommended that coverage of gram-positive organisms is also started as early as possible.<br />
For fractures of grade 3 according to Gustilo, additional treatment for gram-negative triggers and<br />
also high-dose penicillin should be administered for farm-related injuries as a prophylaxis<br />
against clostridial infections. The treatment should be continued up to 24 hours after primary<br />
defect covering. With grade 3 fractures, the antibiotic treatment should be continued up to 72<br />
hours after the trauma and not more than 24 hours after soft tissue has been covered [98]. As<br />
with a series of other studies [68], Dellinger et al. [42] could not show any significant difference<br />
in infection rate in 248 patients in relation to the period of antibiotic prophylaxis (1 versus 5<br />
days).<br />
Although some authors recommend the administration of antibiotic-impregnated beads for local<br />
infection prophylaxis in addition to i.v. antibiosis, there is no supporting literature of EL 1 on<br />
this either [68, 70, 124, 170].<br />
Emergency surgery phase – Lower extremity 391
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Key recommendation:<br />
Provided the severity of the overall injury permits, the surgical management<br />
of vascular injuries in the lower extremity should be carried out at the earliest<br />
possible opportunity, i.e. directly after treating the injuries threatening the<br />
vital functions.<br />
Explanation:<br />
GoR B<br />
There are only few confirmed data on the incidence of arterial and venous vascular injuries of<br />
the lower extremity in multiply injured patients. There is wide variation worldwide among the<br />
individual collectives in degree of severity, the mechanism of generation, the location of the<br />
vascular injury (and of the other injuries), and the quality of the preoperative diagnostic study<br />
and management [147, 177, 181, 185, 190]. The morphologic damage to the vessels in relation to<br />
the mechanism of generation is accurately described in its importance for the type of<br />
management [192].<br />
The management recommendations listed here are based predominantly on the experiences and<br />
recommendations of experts who have published their results and conclusions from individual<br />
collectives. Only one publication is based on a controlled randomized trial [193]. However, the<br />
published recommendations from different subdivisions of trauma surgery and vascular surgery<br />
permit only qualified conclusions on the treatment of severe injuries in the lower extremity with<br />
vascular involvement in multiply injured patients. Ultimately, therefore, it is an individual<br />
decision for the individual patient.<br />
Provided the severity of the overall injury permits, the surgical management of arterial and<br />
venous injuries in the lower extremity should also be carried out in multiply injured patients at<br />
the earliest possible opportunity, i.e. directly after treating the injuries threatening the vital<br />
functions. There is no consensus in the literature on whether a fracture must be stabilized first<br />
followed by vascular reconstruction or whether the reverse sequence is advantageous. Discussion<br />
also surrounds interim solutions (primary shunt insertion to preserve blood supply, fracture<br />
stabilization and later definitive vascular reconstruction or in terms of damage control through to<br />
physiologic recompensation of the patient after severe trauma) [81, 108, 117, 120, 123, 127, 143,<br />
180]. In complex trauma with a high prediction probability of vascular injury, primary vascular<br />
revision should be carried out with, if necessary, immediate vascular reconstruction [193]. The<br />
resources, principles of surgery, and operative techniques available correspond to those for nontrauma-induced<br />
management of arterial and venous reconstructions and partly exceed the<br />
indication range.<br />
Arterial injuries of the iliac and femoral vessels should be reconstructed and are usually<br />
technically easily accessible. An isolated crural artery injury can be ligated if the openness of the<br />
other distal main arteries is confirmed. If at least 2 vessels are affected, there is almost always a<br />
critical vascular disorder which requires primary revascularization. The combination with venous<br />
injuries increases the amputation rate, which is why the indication for venous reconstruction<br />
should be made broadly in combination injuries [50, 177, 181]. Arterial injuries of the lower<br />
Emergency surgery phase – Lower extremity 392
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
extremity should be managed (in descending order) by means of direct suture, insertion of a<br />
continuity-preserving anastomosis, patch angioplasty (autologous, synthetic material) or bypass<br />
reconstruction (autologous, synthetic material, composite) [46, 190]. Venous injuries of the<br />
lower extremity should be managed (in descending order) by means of patch graft, autologous<br />
vein interposition graft, PTFE (polytetrafluorethylene) interposition graft or primary ligature [1,<br />
111, 129, 141, 142, 154, 183].<br />
The indication for fasciotomy should be made early; if necessary it should be carried out even<br />
before vascular reconstruction [49, 177].<br />
Endovascular treatment of arterial injuries represents another option for managing arterial<br />
injuries of the lower extremity even in the multiply injured patient. Established procedures<br />
applied proximal to the extremity (coiling, covered stents) can also be used peripherally in<br />
individual cases. The goal can even be temporary revascularizations until definitive surgical<br />
management [106, 116, 149, 167].<br />
Key recommendation:<br />
In the case of compartment syndrome in the lower extremity, immediate<br />
compartment decompression and fixation of a concomitant fracture must be<br />
carried out.<br />
Explanation:<br />
GoR A<br />
Compartment syndromes in relation to fractures of long bones in the lower extremity and<br />
particularly in the tibia are not rare. Due to the deleterious sequelae within a few hours, however,<br />
they require rapid decompression (fasciotomy) during fracture stabilization. Van den Brand et al.<br />
[187] even support prophylactic versus therapeutic fasciotomy. Establishing an early diagnosis is<br />
essential if there is compartment syndrome because irreversible damage to musculature and<br />
nerves results after 8 hours at the latest [196]. The diagnosis is made in the primary phase<br />
according to clinical criteria [74]. Normal pallor and skin temperature and the presence of distal<br />
pulses [66, 74, 115, 196] do not exclude a compartment syndrome. The cardinal symptom of<br />
pain and pain-provoking muscle extension and sensitivity tests are not usable in the multiply<br />
injured patient who is generally unconscious or analgesic sedated. For this reason, according to<br />
Rowland et al. [162], the definitive diagnosis must be established using a pressure measurement<br />
device. Compartment pressures exceeding 30 mmHg or, in the case of hypotension, exceeding<br />
the difference pdiastolic - 30 mmHg are classed as critical values and indication for fasciotomy [66,<br />
92, 110, 115, 196]. If the diagnosis of compartment syndrome has been established, immediate<br />
fasciotomy (emergency intervention) is indicated [66, 74, 115, 196]. All 4 compartments in the<br />
lower leg should be opened. The prognosis depends on the totality of the injuries and is most<br />
favorable in the case of isolated compartment without fracture. If there is a concomitant fracture,<br />
stable osteosynthesis should be carried out in addition to the fasciotomy. The preferred stable<br />
osteosynthesis is intramedullary nailing [48, 189] as, compared to other procedures, it causes the<br />
least irritation to the soft tissue and avoids the necessity of pin transfixation of the tissue. In a<br />
meta-analysis by Bhandari et al. [14], the drilled medullary nail was compared to the non-drilled<br />
Emergency surgery phase – Lower extremity 393
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
medullary nail with regard to the relative risk of compartment syndrome. Although not<br />
significant (relative risk 0.45; 95% CI: 0.13-1.56), the authors concluded that the drilling of the<br />
medullary nail appears to lower the risk of compartment syndrome. Nevertheless, the conclusion<br />
of rapid action is based less on specific studies on compartment syndrome in polytrauma but<br />
rather much more on experience.<br />
Key recommendation:<br />
The decision to amputate or to salvage the extremity in the critical injury to<br />
the lower extremity should be made on an individual basis. The local and<br />
general condition of the patient plays a crucial role here.<br />
Explanation:<br />
GoR B<br />
The critical injury to the lower extremity can represent a complex problem in the treatment of<br />
polytrauma. The critical decision between amputation and salvaging the extremity can be<br />
necessary here. The literature shows that loss of neurologic function is correlated with delayed<br />
amputation and increased morbidity as well as mortality [2]. Early amputation should be<br />
considered if there is a loss of function and sensitivity in the foot/extremity. Conversely, if there<br />
is function and sensitivity in the foot/extremity, the goal should be to salvage [2]. Thus, the focus<br />
should be on amputation for all patients, for example, with a type III-C fracture and a completely<br />
severed sciatic or tibial nerve. In the case of significant nerve severance, no studies have shown<br />
an advantage in salvaging the extremity compared to early amputation [17, 109, 163].<br />
Vascular integrity increases the probability of salvaging the extremity [161]. The vascular<br />
disorder should be remedied as quickly as possible. An ischemic period of > 6 hours was<br />
correlated with irreversible nerve damage and loss of function [95, 178]. For logical reasons,<br />
necrotic extremities (or parts thereof) should be amputated. A delay in amputation leads to a<br />
significant increase in sepsis, immobility, number of surgical interventions required, mortality,<br />
and costs [17, 109, 163].<br />
Many reports have been published about objective criteria for the decision to amputate or<br />
salvage the extremity [36, 57, 76, 85]. However, to date, no study could define guaranteed<br />
prediction instruments for this decision. Scoring systems (e.g., Predictive Salvage Index,<br />
Mangled Extremity Severity Score [MESS], Limb Salvage Score, NISSSA [Nerve Injury,<br />
Ischemia, Soft Tissue injury, Skeletal injury, Shock and Age of Patient] Scoring Index) can be<br />
used to supplement the clinical assessment. Thus, it is absolutely essential that an individual<br />
decision is taken for each patient and for each injury. The decision to amputate or to salvage the<br />
extremity should never be taken solely on the basis of a protocol or algorithm [16].<br />
In summary, the primary and secondary amputation rate in injuries of the lower extremity<br />
(without them being predictable, e.g.,, through scoring systems) thus depends on the number and<br />
location level of the simultaneously injured arterial and venous vessels, the injured nerves, the<br />
overall severity of the injuries, and the extent of the concomitant soft tissue damage [7, 49, 50,<br />
82, 87, 107, 112, 123, 150, 171, 172, 175, 177, 181, 190].<br />
Emergency surgery phase – Lower extremity 394
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Aitken RJ, Matley PJ, Immelman EJ Lower limb vein<br />
trauma: a long-term clinical and physiological<br />
assessment. Br J Surg 1989; 76(6): 585-8<br />
2. Alexander J, Piotrowski J, Graham D, Franceschi D,<br />
King T. Outcome of complex vascular and<br />
orthopaedic injuries of the lower extremity. Am J<br />
Surg 1991;162:111-116 [LoE 3]<br />
3. American Society of Health-System Pharmacists<br />
ASHP. Therapeutic Guidelines on Antimicrobial<br />
Prophylaxis in Surgery. Am J Health Sys Pharm<br />
1999. 56:1839-1888 [Evidenzbasierte Leitlinie]<br />
4. Ankin NL. Surgical treatment of fractures of long<br />
bones in a patient with multiple injuries. Klin Khir<br />
(1998) 7:41-44<br />
5. Anwar IA, Battistella FD, Neiman R, Olson SA,<br />
Chapman MW, Moehring HD. Femur fractures and<br />
lung complications: a prospective randomized stuy of<br />
reaming. Clin Orthop Relat Res (2004); 422:71-76<br />
[LoE 1]<br />
6. Auf´m Kolk M, Neudeck F, Voggenreiter G,<br />
Schneider K, Obertacke U, Schmit-Neuerburg KP:<br />
Einfluß der primären Oberschenkelplattenosteosynthese<br />
auf den Verlauf polytraumatisierter<br />
Patienten mit und ohne Thoraxtrauma. Unfallchirurg<br />
1998; 101: 433-439 [LoE 3]<br />
7. Ballard JL, Bunt TJ, Malone JM Management of<br />
small artery vascular trauma. Am J Surg 1992;<br />
164(4):316-9<br />
8. Baumgaertner MR, Curtin SL, Lindskog DM, Keggi<br />
JM. The value of the tip-apex distance in predicting<br />
failure of fixation of peritrochanteric fractures of the<br />
hip. J Bone Joint Surg 1995;77A:1058-1064.<br />
9. Baumgaertner MR, Curtin SL, Lindskog DM.<br />
Intramedullary versus extramedullary fixation for the<br />
treatment of intertrochanteric hip fractures. Clin<br />
Orthop (1998) 348:87-94.<br />
10. Beck M, Gradl G, Gierer P, Rotter R, Witt M,<br />
Mittlmeier T. Versorgung der komplikationsbelasteten<br />
proximalen Tibia-Etagenfraktur mit dem<br />
winkelstabilen Less-invasive-stabilization-System.<br />
Unfallchirurg 2008; 111:493-498.<br />
11. Bennett WF, Browner B. Tibial plateau fractures: a<br />
study of associated soft tissue injuries. J Orthop<br />
Trauma 1994;8:183-188 [LoE 2b]<br />
12. Benterud JG, Husby T, Nordsletten L, Alho A.<br />
Fixation of displaced femoral neck fractures with a<br />
sliding screw plate and a cancellous screw or two<br />
Olmed screws. A prospective, randomized study of<br />
225 elderly patients with a 3-year follow-up. Ann<br />
Chir Gynaecol (1997) 86:338-342.<br />
13. Bhandari M, Devereaux PJ, Swiontkowski MF,<br />
Tornetta P, Obremskey W, Koval KJ, Nork S,<br />
Sprague S, Schemitsch EH, Guyatt GH. Internal<br />
fixation compared with arthroplasty for displaced<br />
fractures of the femoral neck. JBJS (2003) 85-<br />
A:1673-1681.<br />
14. Bhandari M, et al. Reamed versus nonreamed<br />
intramedullary nailing of lower extremity long bone<br />
fractures: a systematic overwiew and metaanalysis. J<br />
Orthop Trauma 2000; 14:2-9 [LoE 1]<br />
15. Bhandari M, Guyatt GH, Swiontkowski MF,<br />
Schemitsch EH. Treatment of open fractures of the<br />
shaft of the tibia. J Bone Joint Surg (Br) (2001)<br />
83:62-68 [LoE 1]<br />
16. Bonanni F, Rhodes M, Lucke J. The futility of<br />
predictive scoring of mangled lower extremities. J<br />
Trauma 1993;34:99-104 [LoE 5]<br />
17. Bondurant FL, Cotler HB, Buckle R, Miller-Crotchett<br />
P, Browner BD. Medical and economic impact of<br />
severely injured lower extremities. J Trauma<br />
1988;28:1270-1273 [LoE 3]<br />
18. Bone LB, Babikian G, Stegemann PM: Femoral canal<br />
reaming in the polytrauma patient with chest injury:<br />
A clinical perspective. Clin Orthop 1995; 318: 91-94<br />
[LoE 3]<br />
19. Boos N, Bugyi I. Results of locking intramedullary<br />
nailing in distal tibial shaft fractures. Unfallchirurg<br />
1989;92:453-458.<br />
20. Bosse MJ, Machenzie EJ, Riemer BL, Brumback RJ,<br />
McCarthy ML, Burgess AR: Adult respiratory<br />
distress syndrome, pneumonia and mortality<br />
following thoracic injury and femoral fracture treated<br />
either with intramedullary nailing with reaming or<br />
with a plate. A comparative study. J Bone Joint Surg<br />
Am, 1997; 79: 799-809 [LoE 2a]<br />
21. Boyd RJ, Burke JF, Colton T. A double blinded<br />
clinical trial of prophylactic antibiotics in hip<br />
fractures. J Bone Joint Surg 1973. 55:1251-1258.<br />
22. Bray TJ, Endicott M, Capra SE. Treatment of open<br />
ankle fractures: immediate internal fixation versus<br />
closed immobilization and delayed fixation. Clin<br />
Orthop 1989; 240:47-52 [LoE 3]<br />
23. Bredahl C, Nyholm B, Hindsholm KB, et al.<br />
Mortality after hip fracture: results of operation<br />
within 12 hours of admission. Injury (1992) 23:83-86.<br />
24. Brien WW, Wiss DA, Becker V, Lehman T.<br />
Subtrochanteric femur fractures: a comparison of the<br />
Zickel nail, 95 degrees blade plate, and interlocking<br />
nail. J Orthop Trauma 1991;2:458-464.<br />
25. Brink O, Staunstrup H, Sommer J. Stable lateral<br />
malleolar fractures treated with Aircast Ankle Brace<br />
and Don Joy R.O.M.-Walker Brace: A prospective<br />
randomized study. Foot Ankle Int (1996) 17: 679-684<br />
[LoE 1]<br />
26. Brumback RJ, McGarvey WC. Fractures of the tibial<br />
plafond: the pilon fracture. Evolving treatment<br />
concepts. Orthop Clin North Am 1995;26:273-285<br />
[LoE 5]<br />
27. Brumback RJ, ToalTR, Murphy-Zane MS, Novak<br />
VP, Belkoff SM. Immediate weight-bearing after<br />
treatment of a comminuted fracture of the femoral<br />
shaft with a statically locked intramedullary nail. J<br />
Bone Joint Surg 1999;81A:1538-1544 [LoE 2b]<br />
28. Brumback RJ, Uwagie-Ero S, Lakatos RP, Poka A,<br />
Bathon GH, Burgess AR. Intramedullary nailing of<br />
femoral shaft fractures. Part II. Fracture-healing with<br />
Emergency surgery phase – Lower extremity 395
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
static interlocking fixation. J Bone Joint Surg<br />
1988;70A:1453-1462 [LoE 2b]<br />
29. Buciuto R, Hammer R. RAB-plate versus sliding hip<br />
screw for unstable trochanteric hip fractures: stability<br />
of the fixation and modes of failure – radiographic<br />
analysis of 218 fractures. J Trauma (2001) 50:545-<br />
550.<br />
30. Buciuto R, Uhlin B, Hammerby S, Hammer R. RABplate<br />
vs Richards CHS plate for unstable trochanteric<br />
hip fractures. A randomized study of 233 patients<br />
with 1-year follow up. Acta Orthop Scand (1998)<br />
69:25-28.<br />
31. Buckley R, Huges G, Snodgrass T, Huchcroft SA.<br />
Perioperative cefazolin prophylaxis in hip fracture<br />
surgery. Can J Surg 1990. 33:122-127.<br />
32. Buckley SL, Smith GR, Sponseller PD, Thompson<br />
JD, Griffin PP. Open fractures of the tibia in children.<br />
J Bone Joint Surg 1990;72A:1462-1469.<br />
33. Butler MS, Brumback RJ, Ellison TS, Poka A,<br />
Bathon GH, Burgess AR. Interlocking intramedullary<br />
nailing for ipsilateral fractures of the femoral shaft<br />
and distal part of the femur. J Bone Joint Surg<br />
1991;73A:1492-1502.<br />
34. Calder SJ, Anderson GH, Jagger C, et al. Unipolar or<br />
bipolar prosthesis for displaced intracapsular hip<br />
fracture in octogenarians: a randomised prospective<br />
study. J Bone Joint Surg Br (1996) 78:391-394.<br />
35. Canadian Orthopaedic Trauma Society. Reamed<br />
versus unreamed intramedullary nailing of the femur:<br />
comparison of the rate of ARDS in multiple injured<br />
patients. J Orthop Trauma (2006); 20:384-387 [LoE<br />
1]<br />
36. Chih-Hung L, Fu-Chan W, Levin S, Jun-I S, Wen-Lin<br />
Y. The functional outcome of lower-extremity<br />
fractures with vascular injury. J Trauma 1997;43:480-<br />
485.<br />
37. Chilov MN, Cameron ID, March LM. Evidencebased<br />
guidelines for fixing broken hips: an update.<br />
MJA (2003) 179:489-493 [Evidenzbasierte Leitlinie]<br />
38. Chinoy MA, Parker MJ. Fixed nail plates versus<br />
sliding hip systems for the treatment of trochanteric<br />
femoral fractures: a meta analysis of 14 studies.<br />
Injury (1999) 30:157-163.<br />
39. Cornell CN, Levine D, O`Doherty J, Lyden J.<br />
Unipolar versus bipolar hemiarthroplasty for the<br />
treatment of femoral neck fractures in the elderly.<br />
Clin Orthop (1998) 348:67-71.<br />
40. Dedmond BT, Almekinders LC. Operative versus<br />
nonoperative treatment of knee dislocations – A<br />
Meta-Analysis. Am J Knee Surg 2001; 14: 33-38<br />
[LoE 2c]<br />
41. DeLee JC, Heckman JD, Lewis AG. Partial<br />
fibulectomy for ununited fractures of the tibia. J Bone<br />
Joint Surg Am 1981;63:1390-1395.<br />
42. Dellinger EP, Caplan ES, Weaver LD, Wertz MJ,<br />
Droppert BM, Hoyt N, Brumback R, Burgess A, Poka<br />
A, Benirschke SK. Duration of preventive antibiotic<br />
administation for open extremity fractures. Arch Surg<br />
1988. 123:333-339 [LoE 1]<br />
43. Desjardins AL, Roy A, Paiement G, Newman N,<br />
Pedlow F, Desloges D, Turcotte RE. Unstable<br />
intertrochanteric fracture of the femur: a prospective<br />
randomized study comparing anatomical reduction<br />
and medial displacement osteotomy. J Bone Joint<br />
Surg 1993;75B:445-447.<br />
44. Dietrich A, Lill H, Engel T, Schönfelder M, Josten C.<br />
Conservative functional treatment of ankle fractures.<br />
Arch Orthop Trauma Surg (2002) 122: 165–168 [LoE<br />
2b]<br />
45. Dolk T. Operation in hip fracture patients – analysis<br />
of the time factor. Injury (1990) 21:369-372 [LoE 3]<br />
46. Dorweiler B, Neufang A, Schmiedt W, Hessmann<br />
MH, Rudig L, Rommens PM, Oelert H Limb trauma<br />
with arterial injury: long term performance of venous<br />
interposition grafts. Thorac Cardiovasc Surg 2003;<br />
51(2):67-72<br />
47. Duchesneau S, Falat LM. The Maisonneuve fracture.<br />
J Foot Ankle Surg (1995) 34: 422-428 [LoE 5]<br />
48. Echtermeyer V. Kompartment Syndrom. Prinzipien<br />
der Therapie. Unfallchirurg 1991; 94:225-230.<br />
49. Fainzilber G, Roy-Shapira A, Wall MJ, Jr., Mattox<br />
KL Predictors of amputation for popliteal artery<br />
injuries. Am J Surg 1995;170(6): 568-70<br />
50. Faris IB, Raptis S, Fitridge R Arterial injury in the<br />
lower limb from blunt trauma. Aust N Z J Surg<br />
1997;67(1): 25-30<br />
51. Friedl HP, Trentz O: Marknagelung im Rahmen der<br />
Versorgung bei <strong>Polytrauma</strong>tisierten. Op J (1995) 11:<br />
308-312<br />
52. Fritz T, Hiersemann K, Krieglstein C, Friedl W.<br />
Prospective randomized comparison of gliding nail<br />
and gamma nail in the therapy of trochanteric<br />
fractures. Arch Orthop Trauma Surg (1999) 119:1-6.<br />
53. Gillespie WJ, Walenkamp G. Antibiotic prophylaxis<br />
for surgery for proximal femoral and other closed<br />
long bone fractures (Cochrane Review). In: The<br />
Cochrane Library, Issue 1, 2003. Oxford: Update<br />
Software [LoE 1]<br />
54. Goldhagen PR, O`Conner DR, Schwarze E. A<br />
prospective comparative study of the compression hip<br />
screw and the gamma nail. J Orthop Trauma<br />
1994;5:367-372.<br />
55. Grass R, Herzmann K, Biewener A, Zwipp H.<br />
Verletzungen der unteren tibiofibularen<br />
Syndesmose.Unfallchirurg (2000) 103:520–532 [LoE<br />
5]<br />
56. Green NE, Allen BL. Vascular injuries associated<br />
with dislocation of the knee. J Bone Joint Surg Am<br />
1977; 59: 236-9 [LoE 2c]<br />
57. Gregory R, Randolph G, Peclet M, Wagner JS,<br />
Gilbert DA, Wheeler JR, Snyder SO, Gayle RG,<br />
Schwab CW. The mangled extremity syndrome<br />
(MES): a severity grading system for multisystem<br />
injury of the extremity. J Trauma 1985;25:1147-1150<br />
[LoE 3]<br />
58. Guanche CA, Markman AW. Arthroscopic<br />
management of tibial plateau fractures. Arthroscopy<br />
1993;9:467-471 [LoE 3]<br />
59. Gustilo RB, Anderson JT. Prevention of infection in<br />
the treatment of one thousand and twenty-five open<br />
fractures of long bones:retrospective and prospective<br />
analyses. J Bone Joint Surg 1976;58A:453-458.<br />
Emergency surgery phase – Lower extremity 396
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
60. Gustilo RB, Gruninger RP, Davis T. Classification of<br />
type III (severe) open fractures relative to treatment<br />
and results. Orthopedics 1987;10:1781-1788.<br />
61. Gustilo RB, Mendoza RM, Williams DN. Problems<br />
in the management of type III (severe) open fractures:<br />
A new classification of type III open fractures. J<br />
Trauma 1984;24:742-746.<br />
62. Gustilo RB. Use of antimicrobials in the management<br />
of open fractures. Arch Surg 1979;114:805-808.<br />
63. Habernek H, Kwasny O, Schmid L, Ortner F.<br />
Complications of interlocking nailing for lower leg<br />
fractures: a 3-year follow up of 102 cases. J Trauma<br />
1992;33:863-869.<br />
64. Haentjens P, Casteleyn P, DeBoeck H, Handelberg F,<br />
Opdecam P. Treatment of unstable intertrochanteric<br />
and subtrochanteric fractures in the elderly patients. J<br />
Bone Joint Surg 1989;71A:1214-1225.<br />
65. Hardy DC, Descamps PY, Krallis P, et al. Use of an<br />
intramedullary hip-screw compared with a<br />
compression hip-screw with a plate for<br />
intertrochanteric femoral fractures. A prospective,<br />
randomized study of one hundred patients. J Bone<br />
Joint Surg Am (1998) 80:618-630.<br />
66. Hargens AR, Akeson WH, Mubarak SJ, Owen CA,<br />
Gershuni DH, Garfin SR, Lieber RL, Danzig LA,<br />
Botte MJ, Gelberman RH. Tissue fluid pressures:<br />
from basic research tools to clinical applications. J<br />
Orthop Res. 1989;7:902-9.<br />
67. Hartin NL, Harris I, Hazratwala K. Retrograde<br />
nailing versus fixed-angle blade plating for<br />
supracondylar femoral fractures: a randomized<br />
controlled trials. ANZ J Surg 2006;76:290-294.<br />
68. Hauser CJ, Adams CA, Eachempati SR, Council of<br />
the Surgical Infection Society. Surgical Infection<br />
Society guideline: prophylactic antibiotic use in open<br />
fractures: an evidence-based guideline. Surg Infect<br />
2006; 7:379-405 [Evidenzbasierte Leitlinie]<br />
69. Helfet DL, Koval K, Pappas J, Sanders RW,<br />
DiPasquale T. Intraarticular „pilon“ fracture of the<br />
tibia. Clin Orthop 1994;298:221-228.<br />
70. Henry SL, Ostermann PA, Seligson D. The<br />
prophylactic use of antibiotic impregnated beads in<br />
open fractures. J Trauma 1990;30:1231-1238 [LoE 3]<br />
71. Hoerer D, Volpin G, Stein H. Results of early versus<br />
delayed surgical fixation of hip fractures in the<br />
elderly: a comparative, retrospective study. Bull Hosp<br />
Jt Dis (1993) 53:29-33.<br />
72. Hoffman CW, Lynskey TG. Intertrochanteric<br />
fractures of the femur: a randomized prospective<br />
comparison of the Gamma nail and the Ambi hip<br />
screw. Aust NZ J Surg (1996) 66:151-155.<br />
73. Hoffmann R, Schmidtmaier G, Schulz R, et al.<br />
Classic nail versus DHS. A prospective randomised<br />
study of fixation of trochanteric femur fractures.<br />
Unfallchirurg (1999) 102:182-190.<br />
74. Holden CE. Compartmental syndromes following<br />
trauma. [LoE 5]<br />
75. Honkonen SE. Indications for surgical treatment of<br />
tibial condyle fractures. Clin Orthop 1994;302:199-<br />
205 [LoE 2b]<br />
76. Howe HR, Poole GV, Hansen KJ, Clark T, Plonk<br />
GW, Koman LA, Pennell TC. Salvage of lower<br />
extremity following combined orthopaedic and<br />
vascular trauma. A predictive salvage index. Am Surg<br />
1987;53:205-208 [LoE 3]<br />
77. Huang FS, Simonian PT, Chansky HA. Irreducible<br />
posterolateral Dislocation of the knee [LoE 5]<br />
78. Hunfeld KP, Wichelhaus TA, Schäfer V, Rittmeister<br />
M. Perioperative Antibiotikaprophylaxe bei<br />
aseptischen Eingriffen in der Orthopädie. Orthopäde<br />
1998. 32:1070-1077 [LoE 2]<br />
79. Iannacone WM, Bennett FS, DeLong WG, Born CT,<br />
Dalsey RM. Initial experience with the treatment of<br />
supracondylar femoral fractures using the<br />
supracondylar intramedullary nail: a preliminary<br />
report. J Orthop Trauma 1994;8:322-327.<br />
80. Inan M, Halici M, Ayan I, Tuncel M, Karaoglu S.<br />
Treatment of type IIIA open fractures of tibial shaft<br />
with Ilizarov external fixator versus unreamed tibial<br />
nailing. Arch Orthop Trauma Surg 2007; 127:617-<br />
623.<br />
81. Jaggers RC, Feliciano DV, Mattox KL, Graham JM,<br />
DeBakey ME Injury to popliteal vessels. Arch Surg<br />
1982; 117(5):657-61<br />
82. Jarde O, Abet D, Pietri J [Bone and vascular injuries<br />
of the popliteal fossa. Apropos of 21 cases]<br />
Phlebologie 1985; 38(2): 347-52<br />
83. Jekic IM, Jekic ML. The status of plate<br />
osteosynthesis in the treatment of femur shaft fracture<br />
in polytrauma patients. Helv Chir Acta (1994)<br />
60:611-613.<br />
84. Jiang R, Luo CF, Wang MC, Yang TY, Z<strong>eng</strong> BF. A<br />
comparative study of Less Invasive Stabilization<br />
System (LISS) fixation and two-incision double<br />
plating for the treatment of bicondylar tibial plateau<br />
fractures. Knee 2008; 15:139-143.<br />
85. Johansen K, Daines M, Howey T, Helfet D, Hansen<br />
ST. Objective criteria accurately predict amputation<br />
following lower extremity trauma. J Trauma<br />
1990;30:568-573 [LoE 3]<br />
86. Johansson T, Jacobsson SA, Ivarsson I, et al. Internal<br />
fixation versus total hip arthroplasty in the treatment<br />
of displaced femoral neck fractures: a prospective<br />
randomized study of 100 hips. Acta Orthop Scand<br />
(2000) 71:597-602.<br />
87. Katzman SS, Dickson K, Determining the prognosis<br />
for limb salvage in major vascular injuries with<br />
associated open tibial fractures. Orthop Rev 1992;<br />
21(2): 195-9<br />
88. Kayali C, Agus H, Turgut A. Successful results of<br />
minimally invasive surgery for comminuted<br />
supracondylar femoral fractures with LISS:<br />
comparative study of multiply injured and isolated<br />
femoral fractures. J Orthop Sci 2007;12:458-465.<br />
89. Koval KJ. Intramedullary nailing of proximal femur<br />
fractures. Am J Orthop (2007); 36(4Suppl):4-7.<br />
90. Kregor PJ, Song KM, Routt ML, Sangeorzan BJ,<br />
Liddell RM, Hansen ST. Plate fixation of femoral<br />
shaft fractures in multiply injured children. J Bone<br />
Joint Surg Am (1993) 75:1774-1780.<br />
Emergency surgery phase – Lower extremity 397
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
91. Krettek C, Schandelmaier P, Lobenhoffer P, Tscherne<br />
H. Komplextrauma des Kniegelenks. Unfallchirurg<br />
1996; 99: 616-627<br />
92. Köstler W, Strohm PC, Südkamp NP. Acute<br />
compartment syndrome of the limb. Injury 2004;<br />
35:1221-1227.<br />
93. Lagerby M, Asplund S, Ringqvist I. Cannulated<br />
screws for fixation of femoral neck fractures. No<br />
difference between Uppsala screws and Richards<br />
screws in a randomized prospective study of 268<br />
cases. Acta Orthop Scand (1998) 69:387-391.<br />
94. Larsen LB, Madsen JE, Hoiness PR, Ovre S. Should<br />
insertion of intramedullary nails for tibial fractures be<br />
with or without reaming? A prospective, randomized<br />
study with 3.8 years’ follow up. J Orthop Trauma<br />
2004; 18:144-149.<br />
95. Lazarides MK, Arvanitis DP, Kopadis GC,<br />
Tsoupanos SS, Dayantas JN. Popliteal artery and<br />
trifurcation injuries: is it possible to predict the<br />
outcome? Eur J Vasc Surg 1994;8:226-230.<br />
96. Lhowe DW, Hansen ST. Immediate nailing of open<br />
fractures of the femoral shaft. J Bone Joint Surg<br />
1988;70A:812-820.<br />
97. Lottes JO. Intramedullary nailing of the tibia. Instr<br />
Course Lect 1958;15:65-77.<br />
98. Luchette FA, Bone LB, Born CT, DeLong WG, Hoff<br />
WS, Mullins D, Palumbo F, Pasquale MD. EAST<br />
practice management Guidelines work group:<br />
Practice management guidelines for prophylactic<br />
antibiotic use in open fractures. www.east.org; 2000<br />
[Evidenzbasierte Leitlinie]<br />
99. Lunsjo K, Ceder L, Thorngren KG, et al.<br />
Extramedullary fixation of 569 unstable<br />
intertrochanteric fractures: a randomized multicenter<br />
trial of the Medoff sliding plate versus three other<br />
screw-plate systems. Acta Orthop Scand (2001)<br />
72:133-140.<br />
100. Lunsjo K, Ceder L, Tidermark J, et al.<br />
Extramedullary fixation of 107 subtrochanteric<br />
fractures: a randomized multicenter trial of the<br />
Medoff sliding plate versus 3 other screw-plate<br />
systems. Acta Orthop Scand (1999) 70:459-466.<br />
101. Lu-Yao GL, Keller RB, Littenberg B, Wennberg JE.<br />
Outcomes after displaced fractures of the femoral<br />
neck: a metaanalysis of one hundred and six<br />
published reports. J Bone Joint Surg 1994;76A:15-25.<br />
102. Madsen JE, Naess L, Aune AK, et al. Dynamic hip<br />
screw with trochanteric stabilizing plate in the<br />
treatment of unstable proximal femoral fractures: a<br />
comparative study with the Gamma nail and<br />
compression hip screw. J Orthop Trauma (1998)<br />
12:241-248.<br />
103. March LM, Cameron ID, Cumming RG, et al.<br />
Mortality and morbidity after hip fracture: can<br />
evidence based clinical pathways make a difference?<br />
J Rheumatol (2000) 27:2227-2231.<br />
104. March LM, Chamberlain AC, Cameron ID et al. How<br />
best to fix a broken hip. Fractured Neck of Femur<br />
Health Outcomes Project Team. Med J Aust (1999)<br />
170:489-494.<br />
105. Mariani PP, Santoriello P, Iannone S, Condello V,<br />
Adriani E. Comparison of surgical treatments for<br />
knee dislocation. Am J Knee Surg 1999; 12: 214-221<br />
106. Marin ML, Veith FJ, Cynamon J et al. Initial<br />
experience with transluminally placed endovascular<br />
grafts for the treatment of complex vascular lesions.<br />
Ann Surg 1995; 222(4):449-469<br />
107. Martin LC, McKenney MG, Sosa JL, Ginzburg E,<br />
Puente I, Sleeman D, Zeppa R Management of lower<br />
extremity arterial trauma. J Trauma 1994; 37(4):<br />
591-8<br />
108. McHenry TP, Holcomb JB, Aoki N, Lindsey RW<br />
Fractures with major vascular injuries from gunshot<br />
wounds: implications of surgical sequence. J Trauma<br />
2002 Oct; 53(4):717-21<br />
109. McNamara MG, Heckman JD, Corley FG. Severe<br />
open fractures of the lower extremity: a retrospective<br />
evaluation of the Mangled Extremity Severity Score<br />
(MESS). J Orthop Trauma 1994;8:81-87 [LoE 3]<br />
110. McQueen MM, Court-Brown CM. Compartment<br />
monitoring in tibial fractures. The pressure threshold<br />
for decompression. J Bone Joint Surg Br. 1996;<br />
78:99-104 [LoE 2b]<br />
111. Miranda Junior F, Francisco Junior J, Burihan E The<br />
management of venous trauma: early and late results.<br />
Int angiol 1991; 10(3): 146-51<br />
112. Moniz MP, Ombrellaro MP, Stevens SL, Freeman<br />
MB, Diamond DL, Goldman MH Concomitant<br />
orthopaedic and vascular injuries as predictors for<br />
limb loss in blunt lower extremity trauma. Am Surg<br />
1997; 63(1):24-8<br />
113. Montgomery TJ, Savoie FH, White JL, Roberts TS,<br />
Hughes JL. Orthopedic management of knee<br />
dislocations. Comparison of surgical reconstruction<br />
and immobilisation. Am J Knee Surg 1995; 8: 97-103<br />
114. Moore TM, Patzakis MJ, Harvey JP. Tibial plateau<br />
fractures: definition, demographics, treatment<br />
rationale, and long-term results of closed traction<br />
management or operative reduction. J Orthop Trauma<br />
1987;1:97-119.<br />
115. Mubarak SJ, Hargens AR. Acute compartment<br />
syndromes. Surg Clin North Am. 1983; 63:539-65<br />
[LoE 5]<br />
116. Naidoo NM, CorrPD, Robbs JV, Maharaj, Nair R<br />
Angiographic Embolisation in Arterial trauma. Eur J<br />
Vasc Endovasc Surgery 2000; 19:77-81<br />
117. Nanobashvili J, Kopadze T, Tvaladze M, Buachidze<br />
T, Nazvlishvili G War injuries of major extremity<br />
arteries. Word J Surg 2003 Feb; 27(2):134-9<br />
118. Nast-Kolb D. Marknagelung beim <strong>Polytrauma</strong>. Für<br />
und Wider der Frühversorgung. Unfallchirurg (1997)<br />
100: 80-84 [LoE 3]<br />
119. Neudeck F, Aufmkolk M, Voggenreiter G, Olivier<br />
LC, Majetschak M, Obertacke U: Wieviel<br />
schwermehrfachverletzte Patienten können den<br />
Vorteil der Frühbelastbarkeit nach<br />
Femurmarknagelung nutzen? Unfallchirurg<br />
(Germany), 1998, 101(10), p769-774 [LoE 3]<br />
120. Niedermeier HP, Gefäßverletzungen an den<br />
Extremitäten. Gefässchirurgie 2002 7: 229-232<br />
Emergency surgery phase – Lower extremity 398
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
121. Nork SE, Barei DP, Schildhauer TA, Agel J, Holt SK,<br />
Schrick JL, Sangeorzan BJ. Intramedullary nailing of<br />
proximal quarter tibial fractures. J Orthop Trauma<br />
2006; 20:523-528.<br />
122. Olsson O, Ceder L, Hauggaard A. Femoral shortening<br />
in intertrochanteric fractures. A comparison between<br />
the Medoff sliding plate and the compression hip<br />
screw. J Bone Joint Surg Br (2001) 83:572-578.<br />
123. Orcutt MB, Levine BA, Root HD, Sirinek KR The<br />
continuing chall<strong>eng</strong>e of popliteal vascular injuries.<br />
Am J Surg 1983; 146 (6): 758-61<br />
124. Ostermann PA, Henry SL, Seligson D. The role of<br />
local antibiotic therapy in the management of<br />
compound fractures. Clin Orthop 1998. 295:102-111.<br />
125. Ostermann PA, Neumann K, Ekkernkamp A, Muhr<br />
G. Long-term results of unicondylar fractures of the<br />
femur. J Orthop Trauma 1994;8:142-146 [LoE 2b]<br />
126. Paar O, Kasperk R, Schubert T. Plate osteosynthesis<br />
of the femur in patients with multiple and monotrauma.<br />
Aktuelle Traumatol (1990) 20:171-175.<br />
127. Padberg FT, Jr., Rubelowsky JJ, Hernandez-<br />
Maldonado JJ, Milazzo V, Swan KG, Lee BC,<br />
Hobson RW, 2nd Infrapopliteal arterial injury:<br />
prompt revascularisation affords optimal limb<br />
salvage. J Vasc Surg 1992; 16(6):877-85<br />
128. Pagnani MJ, Lyden JP. Post-operative femoral<br />
fracture after intramedullary fixation with a gamma<br />
nail: a case report and review of the literature. J<br />
Trauma 1994;37:133-137.<br />
129. Pappas PJ, Haser PB, Teehan EP, Noel AA, Silva<br />
MB, Jr., Jamil Z, Swan KG, Padberg FT,Jr., Hobson<br />
RW,2nd Outcome of complex venous reconstructions<br />
in patients with trauma. J Vasc Surg 1997;<br />
25(2):398-404<br />
130. Park SR, Kang JS, Kim HS, et al. Treatment of<br />
intertrochanteric fracture with Gamma AP locking<br />
nail or by a compression hip screw – a randomised<br />
prospective trial. Int Orthop (1998) 22:157-160.<br />
131. Parker MJ, Blundell C. Choice of implant for internal<br />
fixation of femoral neck fractures. Meta-analysis of<br />
25 randomised trials including 4925 patients. Acta<br />
Orthop Scand (1998) 69:138-143 [LoE 1a]<br />
132. Parker MJ, Gurusamy K. Internal fixation versus<br />
arthroplasty for intracapsular proximal femoral<br />
fractures in adults. Cochrane Database Syst Rev<br />
(2006) CD001708 [LoE 1]<br />
133. Parker MJ, Handoll HH, Bhonsle S, Gillespie WJ.<br />
Condylocephalic nails versus extramedullary<br />
implants for extracapsular hip fractures. Cochrane<br />
Database Syst Rev (2002) CD000338 [LoE 1]<br />
134. Parker MJ, Handoll HH, Chinoy MA. Extramedullary<br />
fixation implants for extracapsular hip fractures.<br />
Cochrane Database Syst Rev (2002) CD000339 [LoE<br />
1]<br />
135. Parker MJ, Handoll HH. Gamma and other<br />
cephalocondylic intramedullary nails versus<br />
extramedullary implants for extracapsular hip<br />
fractures. Cochrane Database Syst Rev (2002)<br />
CD000093 [LoE 2]<br />
136. Parker MJ, Handoll HH. Intramedullary nails for<br />
extracapsular hip fractures in adults. Cochrane<br />
Database Syst Rev (2006) CD004961 [LoE 1]<br />
137. Parker MJ, Handoll HH. Replacement arthroplasty<br />
versus internal fixation for extracapsular hip<br />
fractures. Cochrane Database Syst Rev (2006)<br />
CD000086 [LoE 1]<br />
138. Parker MJ, Myles JW, Anand JK, Drewett R. Costbenefit<br />
analysis of hip fracture treatment. J Bone Joint<br />
Surg 1992;74B: p. 261-264 [LoE 2b]<br />
139. Parker MJ, Pryor GA. Gamma versus DHS nailing<br />
for extracapsular femoral fractures. Meta-analysis of<br />
ten randomised trials. Int Orthop (1996) 20: p. 163-<br />
168 [LoE 2]<br />
140. Parker MJ, Pryor GA. Internal fixation or arthroplasty<br />
for displaced cervical hip fractures in the elderly: a<br />
randomised controlled trial of 208 patients. Acta<br />
Orthop Scand (2000) 71: p. 440-446 [LoE 1b]<br />
141. Parry NG, Feliciano DV, Burke RM, Cava RA,<br />
Nicholas JM, Dente CJ, Rozycki GS Management<br />
and short-term patency of lower extremity venous<br />
injuries with various repairs. Am J Surg 2003;<br />
186(6):631-5<br />
142. Pasch AR, Bishara RA, Schuler JJ, Lim LT, Meyer<br />
JP, Merlotti G, Barett JA, Flanigan DP Results of<br />
venous reconstruction after civilian vascular trauma.<br />
Arch Surg 1986;121(5): 607-11<br />
143. Peck JJ, Eastman AB, Bergan JJ, Sedwitz MM, Hoyt<br />
DB, McReynolds DG Popliteal vascular trauma. A<br />
community experience. Arch 1990; 125 (10): 1339-43<br />
144. Pelet S, Arlettaz Y, Chevalley F. Osteosynthesis of<br />
per- and subtrochanteric fractures by blade plate<br />
versus gamma nail. A randomized prospective study.<br />
Swiss Surg (2001) 7:126-133.<br />
145. Pell AC, Christie J, Keating JF, Sutherland GR: The<br />
detection of fat embolism by transoesophageal<br />
schocardiography during reamed intramedullary<br />
nailing. A study of 24 patients with femoral and tibial<br />
fractures. J Bone Joint Surg Br, 1993, 75: 921-925<br />
[LoE 5]<br />
146. Phillips WA, Schwartz HS, Keller CS, et al. A<br />
prospective randomized study of the management of<br />
severe ankle fractures. J Bone Joint Surg 1985;<br />
67A:67-78 [LoE 1b]<br />
147. Piatek S, Bürger T, Halloul Z, Westphal T,<br />
Holmenschlager F, Winckler S. Arterielle<br />
Gefäßverletzungen bei Frakturen und Luxationen.<br />
Zentralbl Chir 2001; 126:379-384.<br />
148. Port AM, McVie JL, Naylor G, Kreibbich DN.<br />
Comparison of two conservative methods of treating<br />
an isolated fracture of the lateral malleolus. JBJS<br />
1996; 78 (B) : 568-572 [LoE 3]<br />
149. Pretre R, Bruschweiler I, rossier J et al. Lower limb<br />
trauma with injury to the popliteal vessels. J Trauma<br />
1996; 40(4): 595-601<br />
150. Radonic V, Baric D, Petricevic A, Andric D, Radonic<br />
S Military injuries to the popliteal vessels in Croatia.<br />
J Cardiovasc Surg (Torino) 1994; 35(1): 27-32<br />
151. Rankin EA, Metz CW. Management of delayed union<br />
in early weight-bearing treatment of the fractured<br />
tibia. J Trauma 1970;10:751-759.<br />
Emergency surgery phase – Lower extremity 399
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
152. Ravikumar KJ, Marsh G. Internal fixation versus<br />
hemiarthroplasty versus total hip arthroplasty for<br />
displaced subcapital fractures of femur – 13 year<br />
results of a prospective randomised study. Injury<br />
(2000) 31:793-797.<br />
153. Ricci WM, Rudzki JR, Borrelli J Jr. Treatment of<br />
complex proximal tibia fractures with the less<br />
invasive skeletal stabilization system. J Orthop<br />
Trauma 2004; 18:521-527.<br />
154. Rich NM Principles and indications for primary<br />
venous repair. Surg 1982;91(5):492-6<br />
155. Richter D, Hahn MP, Laun RA, Ekkernkamp A,<br />
Muhr G, Ostermann PAW. Der Sprunggelenksnahe<br />
Unterschenkelbruch – ist die Osteosynthese mit<br />
ungebohrtem Marknagel ausreichend? Chirurg<br />
1998;69:563-570 [LoE 2b]<br />
156. Richter J, Langer Ch, Hahn JP, Josten C, Muhr G. Ist<br />
die funktionell konservative Behandlung stabiler<br />
Aussenknöchelfrakturen gerechtfertigt? Chirurg<br />
(1996) 67: 1255-1260 [LoE 2b]<br />
157. Richter J. Sprunggelenksfrakturen des Erwachsenen.<br />
Chirurg (2000) 71: 489-502 [LoE 5]<br />
158. Richter M, Bosch U, Wippermann B, Hofmann A,<br />
Krettek C. Comparison of surgical repair or<br />
reconstruction of the cruciate ligaments versus<br />
nonsurgical treatment in patients with traumatic knee<br />
dislocations. Am J Sports Med 2002; 30: 718-27<br />
159. Riemer BL, Butterfield SL, Burke CJ, Mathews D.<br />
Immediate plate fixation of highly comminuted<br />
femoral diaphyseal fractures in blunt polytrauma<br />
patients. Orthopedics (1992) 15:907-916 [LoE 2b]<br />
160. Riemer BL, Miranda MA, Butterfield SL, Burke CJ.<br />
Nonreamed nailing of closed and minor open tibial<br />
fractures in patients with blunt polytrauma. Clin<br />
Orthop 1995; 320:119-124 [LoE 3]<br />
161. Roessler M, Wisner D, Holcroft W. The mangled<br />
extremity. When to amputate? Arch Surg<br />
1991;26:1243-1249.<br />
162. Rowland SA. Fasciotomy: The treatment of<br />
compartment syndrome. In Green,DP,Hotchkiss,RN,<br />
Pederson WC (Hrsg.): Operative Hand Surgery<br />
Churchill Livingstone, New York, Edinburgh,<br />
London, Melbourne, Tokyo 1999, p. 689-710<br />
163. Russell W, Sailores D, Whittle T. Limb salvage<br />
versus traumatic amputation. Ann Surg<br />
1991;213:473-481 [LoE 3]<br />
164. Rüter A, Trentz O, Wagner M (Hrsg).<br />
Unfallchirurgie, 1. Auflage, Urban Schwarzenberg,<br />
München-Wien-Baltimore (1995).<br />
165. Sarmiento A, Gersten LM, Sobol PA, Shankwiler JA,<br />
Vangsness CT. Tibial shaft fractures treated with<br />
functional braces: experience with 780 fractures. J<br />
Bone Joint Surg 1989;71B:602-609 [LoE 3]<br />
166. Scalea TM, Boswell SA, Scott JD, Mitchell KA,<br />
Kramer ME, Pollak AN. External fixation as a bridge<br />
to intramedullary nailing for patients with multiple<br />
injuries and with femur fractures: Damage Control<br />
orthopedics. J Trauma 2000;48:613-623 [LoE 2b]<br />
167. Scheinert D, Schroder M, Steinkamp H et al.<br />
Percutane Therapie katheterinduzierter traumatischer<br />
Gefäßläsion mit Dacronummantelten Nitinolstents.<br />
Zentralbl Chir 2000; 125 (1): 27-33<br />
168. Schmidtmann U, Knopp W, Wolff C, Stürmer KM.<br />
Ergebnisse der elastischen Plattenosteosynthese<br />
einfacher Femurfrakturen beim <strong>Polytrauma</strong>.<br />
Unfallchirurg (1997) 100:949-956 [LoE 2b]<br />
169. Schütz M, Muller M, Regazzoni P, Höntzsch D,<br />
Krettek C, Van der Werken, Haas N. Use of the less<br />
invasive stabilization system (LISS) in patients with<br />
distal femoral (AO33) fractures: a prospective<br />
multicenter study. Arch Orthop Trauma Surg<br />
2005;125:102-108.<br />
170. Seligson D, Ostermann PA, Henry SL, Wolley T. The<br />
management of open fractures associated with arterial<br />
injury requiring vascular repair. J Trauma<br />
1994;37:938-940.<br />
171. Sfeir RE, Khoury GS, Haddad FF, Fakih RR,<br />
Khalifeh MJ Injury to the popliteal vessels: the<br />
Lebanese war experience. World J Surg 1992; 16(6):<br />
1156-9<br />
172. Shap PM, Wapnir I, Babu S, Stahl WM, Clauss RH<br />
Compartment syndrome in combined arterial and<br />
venous injuries of the lower extremity. A J Surg<br />
1989; 158(2): 136-40<br />
173. Slobogean GP, Kennedy SA, Davidson D, O’Brien<br />
PJ. Single- versus multiple-dose antibiotic<br />
prophylaxis in the surgical treatment of closed<br />
fractures: a meta-analysis. J Orthop Trauma 2008;<br />
22:264-269 [LoE 1]<br />
174. Smrke D, Princic J. Platten- und<br />
Schraubenosteosynthese bei Femurschaftfrakturen.<br />
Unfallchirurg (2000) 103:110-114 [LoE 3]<br />
175. Snyder WH, 3rd Popliteal and shank arterial injury.<br />
Surg Clin North Am 1988; 68(4): 787-807<br />
176. Sorensen KH. Treatment of delayed union and nonunion<br />
of the tibia by fibular resection. Acta Orthop<br />
Scand 1969;40:92-104.<br />
177. Sriussadaporn S Arterial injuries of the lower<br />
extremity from blunt trauma. J Med Assoc Thai<br />
1997; 80(2): 121-9<br />
178. Starr AJ, Hunt JL, Rienhart CM. Treatment of femur<br />
fractures with associated vascular injury. J Trauma<br />
1996;40:17-21 [LoE 3]<br />
179. Stocker R, Heinz T, Vecsei V. Results of surgical<br />
management of distal femur fractures with joint<br />
involvement. Unfallchirurg (1995) 98:392-397 [LoE<br />
2b]<br />
180. Subramanian A, Vercruysse G, Dente C,<br />
Wyrzykowski A, King E, Feliciano DV. A decade’s<br />
experience with temporary intravascular shunts at a<br />
civilian level I trauma center. J Trauma 2008; 65:316-<br />
324.<br />
181. Sultanov DD, Usmanov NU, Kurbanov UA, Baratov<br />
AK, Kurbanov NR Surgical management of<br />
traumatic injuries to the tibial arteries. Angiol Sosud<br />
Khir 2003; 9(2):111-7<br />
182. Südkamp N, Haas N, Flory PJ, Tschnerne H, Berger<br />
A: Kriterien der Amputation, Rekonstruktion und<br />
Replantation von Extremitäten bei<br />
Mehrfachverletzten. Chirurg (1989) 60: 774-781<br />
[LoE 5]<br />
Emergency surgery phase – Lower extremity 400
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
183. Timberlake GA, Kerstein MD, Venous injury: to<br />
repair or ligate, the dilemma revisted. Am Surg 1995;<br />
61(2) :139-45<br />
184. Tornetta P III, Weiner L, Bergmen M, Watnek N,<br />
Steuer J, Kelley M, Yang E. Pilon fractures: treatment<br />
with combined internal and external fixation. J<br />
Orthop Trauma 1993;7:489-496.<br />
185. Usmanov NU, Sultanov DD, Baratov AK, Kurbanov<br />
NR [Surgical strategy in traumatic lesions of the<br />
popliteal artery]. Vestn Khir Im II Grek 2003;<br />
162(3):64-8<br />
186. Vallier HA, Le TT, Bedi A. Radiographic and clinical<br />
comparisons of distal tibia shaft fractures (4 to 11 cm<br />
proximal to the plafond): plating versus<br />
intramedullary nailing. J Orthop Trauma 2008;<br />
22:307-311.<br />
187. Van den Brand JGH, Sosef NL, Verleisdonk EJMM,<br />
Van der Werken C. Acute compartment syndrome<br />
after lower leg fracture – long-term results of<br />
prophylactic and therapeutic fasciotomy. Eur J<br />
Trauma 2004; 30:93-97.<br />
188. Van Dortmont LM, Douw CM, van Breukelen AM, et<br />
al. Cannulated screws versus hemiarthroplasty for<br />
displaced intracapsular femoral neck fractures in<br />
demented patients. Ann Chir Gynaecol (2000)<br />
89:132-137.<br />
189. Van Essen GJ, McQueen MM. Compartment<br />
syndrome in the lower limb. Hosp Med 1998; 59:294-<br />
297.<br />
190. Velinovic MM, Davidovic BL, Lotina IS, Vranes<br />
RM, Djukic LP, Arsov JV, Ristic VM, Kocica JM,<br />
Petrovic LP Complications of operative treatment of<br />
injuries of peripheral arteries. Cardiovasc Surg<br />
2000; 8(4):256-64<br />
191. Villar RN, Allen SM, Barnes SJ. Hip fractures in<br />
healthy patients: operative delay versus prognosis.<br />
BMJ (1986) 293:1203-1204 [LoE 2b]<br />
192. Vollmar J Verletzungen der Arterien. In: Vollmar<br />
(Hrsg) Rekonstruktive Chirurgie der Arterien.<br />
Thieme, Stuttgart 1995, pp70-95<br />
193. Waikakul S, Sakkarnkosol S, Vanadurongwan V<br />
Vascular injuries in compound fractures of the leg<br />
with initially adequate circulation. J Bone Joint Surg<br />
Br 1998; 80(2): 254-8<br />
194. Watson JT, Moed BR, Cramer KE, Karges DE.<br />
Comparison of the compression hip screw with the<br />
Medoff sliding plate for intertrochanteric fractures.<br />
Clin Orthop (1998) 348:79-86.<br />
195. Weber TG, Harrington RM, Bradford Henley M,<br />
Tencer AF. The role of fibular fixation in combined<br />
fractures of the tibia and fibula: a biomechanical<br />
investigation. J Orthop Trauma 1997;11:206-211<br />
[LoE 3]<br />
196. Whitesides TE, Heckman MM. Acute Compartment<br />
Syndrome: Update on Diagnosis and Treatment. J<br />
Am Acad Orthop Surg. 1996; 4:209-218Acello AN,<br />
Wallace GF, Pachuda NM. Treatment of open<br />
fractures of the foot and ankle: a preliminary report. J<br />
Foot Ankle Surg 1995;34:329-346 [LoE 5]<br />
197. Whittle AP, Russell TA, Taylor JC, Lavelle DG.<br />
Treatment of open fractures of the tibial shaft with the<br />
use of interlocking nailing without reaming. J Bone<br />
Joint Surg 1992;74A:1162-1171 [LoE 2b]<br />
198. Winquist RA, Hansen ST, Clawson DK. Closed<br />
intramedullary nailing of femoral fractures: a report<br />
of five hundred and twenty cases. J Bone Joint Surg<br />
1984;66A:529-539.<br />
199. Wiss DA, Brien WW. Subtrochanteric fractures of the<br />
femur: results of treatment by interlocking nailing.<br />
Clin Orthop 1992;283:231-236<br />
200. Wozasek GE, Simon P, Redl H et al.: intramedullary<br />
pressure changes and fat intravasation during<br />
intramedullary nailing: An experimental study in<br />
sheep. J Trauma 1994; 36:202-207 [LoE 5]<br />
201. Wu CC, Shih CH. Complicated open fractures of the<br />
distal tibia treated by secondary interlocking nailing.<br />
J Trauma 1993;34:792-796 [LoE 2b]<br />
202. Wyrsch B, McFerran MA, McAndrew M, Limbird<br />
TJ, Harper MC, Johnson KD, Schwartz HS.<br />
Operative treatment of fractures of the tibial plafond.<br />
A randomized, prospective study. J Bone Joint Surg<br />
Am 1996. 78:1646-1657 [LoE 1b]<br />
203. Xenos JS, Hopkinson WJ, Mulligan ME,Olson EJ,<br />
Popovic DM. The tibiofibular syndesmosis.<br />
Evaluation of the ligamentous structures. Methods of<br />
fixation, and radiographic assessment. J Bone Joint<br />
Surg Am (1995) 77:847–856<br />
204. Yde J, Kristensen KD. Ankle fractures. Supinationeversion<br />
fractures stage II. Primary and late results of<br />
operative and non-operative treatment. Acta Orthop<br />
Scand (1981) 51: 695-702<br />
205. Young MJ, Barrack RL. Complications of internal<br />
fixation of tibial plateau fractures. Orthop Rev<br />
1994;23:149-154 [LoE 3]<br />
206. Zalavras C, Velmahos G, Tan Chan L, Patzakis MJ,<br />
Demetriades D: Multiple intramedullary nailing: A<br />
risk factor for respiratory compromise following<br />
femur fractures; Abstract (Paper No.: 249) of the<br />
Annual Meeting of AAOS February 2003 in New<br />
Orleans [LoE 2b]<br />
207. Zehntner MK, Marchesi DG, Burch H, Ganz R.<br />
Alignment of supracondylar /intracondylar fractures<br />
of the femur after internal fixation by AO /ASIF<br />
technique. J Orthop Trauma 1992;6:318-326 [LoE<br />
2b]<br />
Emergency surgery phase – Lower extremity 401
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.11 Foot<br />
The affected patients often have residual pains and restricted function in the foot after<br />
polytrauma management requiring a high level of staff and material resources. The reasons for<br />
foot injuries in polytrauma being missed or underestimated are more eye-catching and lifethreatening<br />
injuries, deficient radiography technique in the emergency situation, extremely<br />
variable clinical standards in the analgesic sedated patient, lack of experience on the part of the<br />
examiner in less common foot injuries, and breakdown in communication in the treatment of the<br />
multiply injured due to several teams working together [45, 60].<br />
The number of studies with relatively high evidence on the topic of management of foot injuries<br />
in the multiply injured patient is remarkably small. This is all the more remarkable as the<br />
presence of foot injuries has a significant negative influence on the prognosis of multiply injured<br />
patients [84]. For the reasons cited, repeated attempts have been made to compile experiencebased<br />
treatment guidelines for these patient groups [52, 60, 76, 77, 92, 93], which, in the absence<br />
of controlled studies, form the basis of the following draft. The aim of this guideline section is<br />
therefore to provide an aid based on the available study data for the timely and appropriate<br />
treatment of foot injuries which is adapted to the extent of injury in the multiply injured patient.<br />
Emergency indications<br />
The necessity of emergency management of open fractures, neurovascular injuries, compartment<br />
syndrome, and an extreme soft tissue hazard is no different from the emergency indication in the<br />
remaining skeletal sections [16, 76, 77]. Accordingly, reference is made to the appropriate<br />
guideline parts.<br />
Topographic features in the foot arise from the danger of avascular necrosis even in closed<br />
dislocation fractures of the talus [15, 25, 34, 77], to a lesser degree also of the navicular bone<br />
[70], and in Lisfranc dislocation fractures and calcaneus fractures, which hold an increased<br />
danger of compartment syndrome [46, 51, 54, 64, 94]. In addition, the closed reduction of<br />
dislocation fractures of the talus and of the Chopart and Lisfranc joint is only possible in<br />
exceptional cases. The cited injuries should be managed immediately following the initial<br />
stabilization of the multiply injured patient.<br />
Emergency surgery phase – Foot 402
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Compartment syndrome in the foot<br />
Key recommendations:<br />
If a manifest compartment syndrome is present in the foot, a fasciotomy must<br />
be performed immediately.<br />
If there is clinical suspicion of compartment syndrome in the foot, a pressure<br />
measurement device can be used to take a measurement.<br />
Explanation:<br />
GoR A<br />
GoR 0<br />
Calcaneus fractures, Lisfranc dislocation fractures, and in general severe crush injuries are<br />
particularly at risk from compartment syndrome [39, 46, 51, 54, 76]. Most authors recommend a<br />
fasciotomy from a threshold of 30 mmHg [47, 50, 51, 87]. In contrast to the lower leg, other<br />
authors recommend compartment splitting even from a threshold of 25 mmHg as blisters develop<br />
more rapidly on the foot and the tolerance of the small foot muscles and terminal branches of the<br />
nerves and vessels is less compared to comparable pressures in the lower leg [93, 94].<br />
In compartment syndrome of the lower leg, attention should be paid to a concomitant foot<br />
compartment syndrome as established by Manoli et al. [40] in a series of 8 cases. There were<br />
multiple injuries in 7 out of 8 cases. In experimental and clinical studies, both the dorsomedial<br />
and the medial fasciotomy (modified Henry approach) permit sufficient decompression of all<br />
foot compartments [40, 50]. In addition, 2 parallel dorsal incisions and a “three-incision<br />
decompression” with additional plantar fasciotomy are described which, however, offer no<br />
obvious advantage.<br />
Open injuries<br />
Soft tissue damage in the foot has a crucial effect on the functional outcome [26, 27, 86].<br />
Aggressive debridement of contaminated and hypoperfused tissue and early soft tissue covering<br />
are essential in the treatment of open fractures in the foot in order to prevent prolonged infection<br />
courses [12, 16, 27, 35, 74, 75, 96].<br />
Bones, joint cartilage, and tendons are at risk even if there is primary vitality if they are not<br />
sufficiently covered by tissue. Artificial skin products can guarantee a temporary closure if a<br />
secondary skin closure is expected after swelling has subsided and consolidation of the soft<br />
tissues or an additional second look is necessary due to severe contamination (farm-related<br />
injuries) [29]. Secondary split thickness skin grafts are suitable for superficial defects in nonweight-bearing<br />
regions. These require a clean (not sterile) wound surface without exposed bones,<br />
joint cartilage or tendons. In children, the requirements for the wound surface are<br />
disproportionately less [1]. The problems of marginal hyperkeratosis in the border region<br />
between transplant and local foot skin are still unresolved [13]. In degloving injuries, the upper<br />
layer (approx. 0.3 mm) of the hypoperfused and potentially avitalized abraded skin can be<br />
detached with the dermatome and be used for covering adjacent sections with vitalized wound<br />
Emergency surgery phase – Foot 403
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
substrate (split-thickness skin excision [89]). In addition, the extent of bleeding after raising the<br />
transplant permits a reliable conclusion to be made on its viability.<br />
Multi-layer defects require a local or free flap transfer [35, 44, 68]. The flap choice here depends<br />
on the size of defect and the blood supply pattern and takes into account the functional-anatomic<br />
foot zone divisions and the like with like principle [1, 28, 44]. Local pedicled flaps are suitable<br />
for covering smaller lateral, medial or plantar defects due to their limited action range [20]. Free<br />
flaps with microvascular anastomosis require an intact attachment point and attention must be<br />
paid to the type of shoe and cosmetic aspects in addition to technical feasibility [66].<br />
Preoperative angiography (if necessary also phlebography) should generally be carried out [35].<br />
More extensive defects on the flat dorsum of foot benefit from free fasciocutaneous flaps<br />
whereas deep, contaminated defect cavities need to be filled with muscle flaps covered with split<br />
thickness skin grafts (e.g., latissimus dorsi). The latter are less bulky than myocutaneous flaps<br />
[41]. The pedicle-rotated sural flap is a suitable salvage procedure in inadequate main vessels [6,<br />
12, 38].<br />
Even in successful extremity salvage, considerable functional deficits often remain after open<br />
pilon, talus, and calcaneus fractures [27, 68, 73]. This is partly explained by arthrogenous and<br />
tendogenic fibroses with corresponding mobility deficit after the necessary longer<br />
immobilization. In open grade 2 and grade 3 lower leg fractures, early defect covering with free<br />
flap transfer is a proven technique compared to delayed covering [11, 17, 19]. In this regard,<br />
reference is made to the section “Open and closed soft tissue damage to the extremities”.<br />
The experiences with the foot are fewer due to smaller patient numbers. In initial series, patients<br />
with larger, contaminated defects due to open foot trauma achieved good functional outcomes<br />
through early flap coverage within 24-120 hours with primary stable osteosynthesis [12, 48].<br />
However, this procedure is only possible in a patient in a stable general condition; in terms of an<br />
optimum functional outcome, all reconstructive options should then be exhausted for the<br />
multiply injured patient as well [56].<br />
As with open fractures in other extremity sections, a single shot antibiotic prophylaxis is also<br />
recommended for open fracture in the foot to supplement the surgical debridement; depending on<br />
the expected, predominantly gram-positive bacteria range, first or second generation<br />
cephalosporins or an antibiotic with comparable effect range in terms of the calculated antibiosis<br />
are used [10, 14, 24, 27, 52, 53].<br />
Emergency surgery phase – Foot 404
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Complex trauma of the foot<br />
Key recommendations:<br />
The decision to amputate the foot should be made on an individual basis. GoR B<br />
Replantation of the foot generally cannot be recommended in polytrauma. GoR 0<br />
Explanation:<br />
The definition of complex foot trauma is based both on the regional extent of the injury across<br />
the 5 anatomic-functional levels of the foot and on the extent of soft tissue damage [92].<br />
According to Tscherne und Oestern [81], 1 point is awarded for each injured foot region and for<br />
each grade of soft tissue damage; the definition of a complex foot trauma is when 5 or more<br />
points are awarded. The absolute score simultaneously permits a prognostic statement [92].<br />
If there is complex foot trauma, the criteria for amputation in relation to the overall injury<br />
severity in polytrauma are not defined precisely. Tscherne [81] recommends primary amputation<br />
with a PTS value (Hannover polytrauma key [65]) of 3-4, and an individual decision if the PTS<br />
is 2. Validated scores such as the Hannover fracture scale (HFS [83]), the MESS (Mangled<br />
Extremity Severity Score [32]) and the NISSSA Score (Nerve Injury, Ischemia, Soft Tissue<br />
Injury, Skeletal Injury, Shock and Age of Patient Score [43]), the Predictive Salvage Index (PSI)<br />
[30], and the Limb Salvage Index (LSI) [67] offer a certain amount of help in decision-making.<br />
In a prospective multicenter study on 601 patients with complex injuries of the lower extremity<br />
(Lower Extremity Assessment Project [LEAP]), a high specificity of all scores (HFS, MESS,<br />
NISSSA, PSI, LSI) was found but with low to moderate sensitivity [7]. This means that a low<br />
score can certainly reliably predict limb salvage but a high score is not predictive for an<br />
amputation. The authors therefore warn against an uncritical application of the scores in deciding<br />
in favor of amputation [7]. In addition, such scores cannot replace in particular individual<br />
consideration of the overall course in the polytrauma and the specific local injury pattern in the<br />
foot [94, 95].<br />
In addition to general criteria such as age, concomitant diseases, and concomitant injuries, the<br />
following points regarding the foot are important in the decision to amputate: the loss of large<br />
parts of the sole of the foot with its unique chambered profile cannot be replaced by equivalent<br />
tissue and is potentially more serious than defects on the dorsum of foot. Vascular injuries<br />
endanger the vitality of distal foot sections and make the restoration of foot function<br />
considerably more difficult [8, 23, 72, 94]. The loss of the protective sensitivity of the sole of the<br />
foot due to a traumatic tibial nerve lesion involves a greater potential for soft tissue-induced late<br />
complications even if sensitivity can be regained within 2 years in about half the cases of blunt<br />
injury of the tibial nerve [9].<br />
Severe comminutions of the bony foot skeleton and joint destruction which necessitate primary<br />
arthrodesis to support osteosynthesis potentially lead to a more rigid foot with non-physiologic<br />
pressure distribution on the sole of the foot, which is often compromised by the trauma anyway.<br />
The traumatic loss of the talus or its joint surfaces through the necessary tibiotalar,<br />
Emergency surgery phase – Foot 405
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
tibiotalocalcaneous or pantalar arthrodesis leads to a rigid foot with considerable functional<br />
impairment even if bones and wounds heal without problems [21, 68, 70]. In all cited cases, the<br />
indication for amputation should be verified early even if there are no life-threatening<br />
concomitant injuries [23, 52, 68]. In these cases, the Pirogoff amputation at least still permits the<br />
original sole of the foot to bear weight; it is also suitable in critical blood supply conditions [92].<br />
In the LEAP Study on 8 North American Level I trauma centers, the most important amputation<br />
criteria in severe high-energy injuries of the lower leg and foot were severe muscle injury (OR<br />
8.74), severe vein injury (OR 5.72), absence of plantar sensitivity (OR 5.26), open foot fracture<br />
(OR 3.12), and absence of foot pulses (OR 2.02). Patient-related factors that influenced the<br />
decision in favor of amputation were hemorrhagic shock and concomitant diseases whereas the<br />
general injury severity (ISS) had no significant influence in this series [78].<br />
In contrast to the vascular-surgical principles of waiting until hypoperfused extremity sections<br />
are demarcated, an early decision on the <strong>final</strong> amputation level is recommended in fresh trauma<br />
for an early definitive soft tissue closure [92, 93]. In principle, there should be no blood arrest<br />
during surgery in order to assess correctly the vitality of bones and musculature [52, 63].<br />
The experiences with replantation are disproportionately fewer in the foot than in the hand and<br />
are restricted to case reports and small case series [4, 5, 18, 88]. The outlook for successful<br />
replantation is markedly greater in children than in adults [3, 31]. Essentially, the attempt should<br />
only be undertaken if a plantigrade, stable foot with protective sensitivity of the sole of the foot<br />
can be regarded as a realistic endpoint of treatment without endangering the patient. Important<br />
criteria for successful replantation are an anoxia period of less than 6 hours and high patient<br />
compliance in the face of slow, difficult rehabilitation [18]. It is almost impossible to estimate<br />
these criteria in the multiply injured patient and replantation that lasts several hours within the<br />
critical ischemia period is generally not indicated due to the general condition of the patient [72].<br />
Emergency surgery phase – Foot 406
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Specific injuries<br />
Key recommendation:<br />
Dislocations and dislocated fractures of the tarsal bones and metatarsals<br />
should be reduced and stabilized as soon as possible.<br />
Explanation:<br />
GoR B<br />
Central dislocation fractures of the talus (aviator’s astragalus) are associated with a polytrauma<br />
with above-average frequency (according to the AO multicenter study in 52% of cases [34]). The<br />
relationship between the occurrence of avascular necrosis of the talus and initial dislocation<br />
extent has been confirmed in several large clinical series [15, 25, 34]. Closed reduction is only<br />
rarely possible in dislocated fractures of the talus, and repeated attempts damage the soft tissues<br />
which are compromised anyway. For this reason, the goal is immediate open reduction and<br />
(mostly minimally invasive) stabilization in dislocated fractures of the talus (if permitted by the<br />
general condition of the multiply injured patient) in order not to endanger further the vitality of<br />
the skin and the talus itself [15, 25, 62, 79]. The definitive management and osteosynthesis of<br />
minor dislocated talus fractures can be carried out later if the patient is in a stable general<br />
condition without there being an increased risk of avascular necrosis of the talus developing [36,<br />
85, 86].<br />
Calcaneus fractures with open wound, manifest compartment syndrome, and incarcerated soft<br />
tissues should be managed by emergency surgery. After the diagnostic study in the case of open<br />
injuries, initial debridement, if necessary artificial skin covering, temporary percutaneous<br />
Kirschner wire osteosynthesis or medial transfixation (each with a Schanz screw in the distal<br />
tibia, in the tuber calcanei and metatarsal I) are carried out to prevent soft tissue retraction [27,<br />
63, 95]. In extensive, bony defects, insertion of PMMA (polymethyl methacrylate) beads is<br />
recommended. A second look operation must generally be carried out within 48-72 hours. The<br />
indication for early flap coverage should be made broadly [12, 48].<br />
In closed grade 3 fractures with manifest compartment syndrome, the emergency<br />
dermatofasciotomy is performed in polytrauma via an extended dorsomedial approach with<br />
insertion of a triangular medial external fixator [63, 95]. The clinical relevance of the plantar<br />
calcaneal compartment, which has been presented in injection studies and in which an isolated<br />
increase in pressure can occur, is not <strong>final</strong>ly clarified but the occurrence of hammer toe<br />
malalignments after isolated calcaneal fractures indicates this problem [39, 54, 96].<br />
In the vast majority of fractures (closed soft tissue damage grade 1 and 2), osteosynthesis is<br />
recommended 6-10 days later after the swelling in the soft tissue has subsided [2, 58, 68, 71, 91,<br />
95]. Elevating the extremity by more than 10 cm above the level of the heart is not recommended<br />
so as to prevent ischemia [16]. A good indicator for surgery time is the onset of skin creasing due<br />
to the subsiding edematous swelling [68]. A surgery time beyond the 14th day is associated with<br />
an increased risk of complications if no reduction and transfixing has been carried out initially<br />
[58, 80]. Local contraindications for osteosynthesis exist if there are critical soft tissue<br />
Emergency surgery phase – Foot 407
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
conditions with high risk of infection such as tension blisters and skin necroses and advanced<br />
arterial or venous vascular disorders; general contraindications are lack of compliance and a<br />
manifest immune weakness [58, 92, 95]. Conservative treatment is indicated in these cases due<br />
to the risk of wound healing disorders and deep infections.<br />
Injuries at the level of the Chopart and Lisfranc joint are associated with multiple injuries with<br />
an above-average frequency (50-80%) [33, 64, 90]. They belong to the most commonly missed<br />
injuries of all, particularly in polytrauma [22, 33, 37, 57, 92].<br />
The closed reduction of Chopart and Lisfranc dislocated fractures is generally not possible so<br />
that there is an indication for emergency surgery in most cases [37, 49]. Lisfranc dislocated<br />
fractures are also associated with an increased risk of compartment syndrome in the foot [51,<br />
64]. If the general condition of the patient permits no definitive osteosynthesis, the goal is<br />
Kirschner wire transfixation and/or the insertion of a tibiometatarsal external fixator; definitive<br />
management should be carried out later [57, 61, 63, 93].<br />
After stabilization of the general condition of the multiply injured patient, fractures of the<br />
metatarsals and toes can be managed later by osteosynthesis according to the general treatment<br />
principles; the above-cited general principles apply to open injuries of the forefoot [59].<br />
Emergency surgery phase – Foot 408
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Attinger CE, Evans KK, Bulan E, Blume P, Cooper P<br />
(2006) Angiosomes of the foot and ankle and clinical<br />
implications for limb salvage: reconstruction, incisions,<br />
and revascularization. Plast Reconstr Surg 117: 261S-<br />
293S [LoE 5]<br />
2. Benirschke SK, Sangeorzan BJ (1993) Extensive<br />
intraarticular fractures of the foot. Surgical<br />
management of calcaneal fractures. Clin Orthop: 128-<br />
134 [LoE 4]<br />
3. Beris AE, Soucacos PN (1994) Major limb replantation<br />
in children. Microsurgery 15: 474-478 [LoE 5]<br />
4. Berger A, Hierner R, Becker MH, Rieck B, Lassner F<br />
(1997) Replantationsschirurgie. Unfallchirurg 100:<br />
694-704 [LoE 4]<br />
5. Betz AM, Stock W, Hierner R, Schweiberer L (1996)<br />
Cross-over replantation after bilateral traumatic lowerleg<br />
amputation: a case report with a six-year follow-up.<br />
J Reconstr Microsurg 12: 247-255 [LoE 4]<br />
6. Boack DH, Bogutsch G, Mittlmeier T, Haas NP (2005)<br />
Der modifizirte erweiterte distal gestielte saphenofasziokutane<br />
Suralislappen. Fuß Sprungg 3: 9-18 [LoE<br />
4]<br />
7. Bosse MJ, MacKenzie EJ, Kellam JF et al. (2001) A<br />
prospective evaluation of the clinical utility of the<br />
lower-extremity injury-severity scores. J Bone Joint<br />
Surg Am 83-A: 3-14 [LoE 2]<br />
8. Bosse MJ, MacKenzie EJ, Kellam JF et al. (2002) An<br />
analysis of outcomes of reconstruction or amputation<br />
after leg-threatening injuries. N Engl J Med 347: 1924-<br />
1931 [LoE 2]<br />
9. Bosse MJ, McCarthy ML, Jones AL et al. (2005) The<br />
insensate foot following severe lower extremity trauma:<br />
an indication for amputation? J Bone Joint Surg Am 87:<br />
2601-2608 [LoE 2]<br />
10. Braun R, enzler MA, Rittmann WW (1987) A doubleblind<br />
clinical trial of prophylactic cloxacillin in open<br />
fractures. J Orthop Trauma 1:12-17 [LoE 1]<br />
11. Bray TJ, Endicott M, Capra SE (1989) Treatment of<br />
open ankle fractures. Immediate internal fixation vs.<br />
closed immobilization and delayed fixation. Clin<br />
Orthop 240: 47-52 [LoE 3]<br />
12. Brenner P, Rammelt S, Gavlik JM, Zwipp H (2001)<br />
Early soft tissue coverage after complex foot trauma.<br />
World J Surg 25: 603-609 [LoE 4]<br />
13. Brenner P, Rammelt S (2002) Abdominal wall and foot<br />
reconstruction after extensive desmoid tumor resection.<br />
Langenbeck's Arch Surg 386: 592-597 [LoE 5]<br />
14. Brown PW (1973) The prevention of infection in open<br />
wounds. Clin Orthop 96: 42-50 [LoE 3]<br />
15. Canale ST, Kelly FB, Jr. (1978) Fractures of the neck<br />
of the talus. J Bone Joint Surg (Am) 60: 143-156 [LoE<br />
4]<br />
16. Chapman MW, Olson SA (1996) The treatment of open<br />
fractures. In: Rockwood CA, Green DP, Bucholz RW<br />
eds) Fractures in adults. J B Lippincott, Philadelphia,<br />
347 ff [LoE 5]<br />
17. Cierny G 3rd, Byrd HS, Jones RE (1983) Primary<br />
versus delayed soft tissue coverage for severe open<br />
tibial fractures. A comparison of results. Clin Orthop.<br />
1983 178: 54-63 [LoE 3]<br />
18. Daigeler A, Fansa H, Schneider W (2003) Orthotopic<br />
and heterotopic lower leg reimplantation. Evaluation of<br />
seven patients. J Bone Joint Surg Br 85: 554-558 [LoE<br />
4]<br />
19. Godina M (1986) Early microsurgical reconstruction of<br />
complex trauma of the extremities. Plast Reconstr Surg<br />
78: 285 [LoE 3]<br />
20. Gould J (1987) Reconstruction of soft tissue injuries of<br />
the foot and ankle with microsurgical techniques.<br />
Orthopedics 10: 151 [LoE 4]<br />
21. Grob D, Simpson LA, Weber BG, Bray T (1985)<br />
Operative treatment of displaced talus fractures. Clin<br />
Orthop 199: 88-96 [LoE 4]<br />
22. Haapamaki V, Kiuru M, Koskinen S (2004) Lisfranc<br />
fracture-dislocation in patients with multiple trauma:<br />
diagnosis with multidetector computed tomography.<br />
Foot Ankle Int 25: 614-619 [LoE 4]<br />
23. Hansen ST, Jr. (2001) Salvage or amputation after<br />
complex foot and ankle trauma. Orthop Clin North Am<br />
32: 181-186 [LoE 5]<br />
24. Hauser CJ, Adams CA, Eachempati SR (2006) Surgical<br />
Infection Societay Guidline. Prophylactic antibiotic use<br />
in open fractures: An evidence-based guideline. Surg<br />
Infect 7: 379-405 [Evidenzbasierte Leitlinie]<br />
25. Hawkins LG (1970) Fractures of the neck of the talus. J<br />
Bone Joint Surg [Am] 52: 991-1002 [LoE 4]<br />
26. Heckman JD, Champine M (1989) New techniques in<br />
the management of foot trauma. Clin Orthop 240: 105<br />
[LoE 5]<br />
27. Heier KA, Infante AF, Walling AK, Sanders RW<br />
(2003) Open fractures of the calcaneus: soft-tissue<br />
injury determines outcome.´J Bone Joint Surg Am 85-<br />
A: 2276-82 [LoE 3]<br />
28. Hidalgo DA, Shaw WW (1986) Anatomical basis of<br />
plantar flap design. Plast Reconstr Surg 78: 627-636<br />
[LoE 4]<br />
29. Horowitz JH, Nichter LS, Kenney JG, et al. (1985)<br />
Lawnmower injuries in children. Lower extremity<br />
reconstruction. J Trauma 25: 1138 [LoE 4]<br />
30. Howe HR, Jr., Poole GV, Jr., Hansen KJ et al. (1987)<br />
Salvage of lower extremities following combined<br />
orthopedic and vascular trauma. A predictive salvage<br />
index. Am Surg 53: 205-208 [LoE 2]<br />
31. Hsiao CW, Lin CH, Wei FC (1994) Midfoot<br />
replantation: case report. J Trauma 36: 280-281 [LoE 5]<br />
32. Johansen K, Daines M, Howey T, Helfet D, Hansen ST<br />
(1990) Objective criteria accurately predict amputation<br />
following lower extremity trauma. J Trauma 30: 568-<br />
573 [LoE 2]<br />
33. Kotter A, Wieberneit J, Braun W, Ruter A (1997) Die<br />
Chopart-Luxation. Eine häufig unterschätzte<br />
Verletzung und ihre Folgen. Eine klinische Studie.<br />
Unfallchirurg 100: 737-741 [LoE 4]<br />
34. Kuner EH, Lindenmaier HL (1983) Zur Behandlung<br />
der Talusfraktur. Kontrollstudie von 262<br />
Behandlungsfällen. Unfallchirurgie 9: 35-40 [LoE 4]<br />
Emergency surgery phase – Foot 409
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
35. Levin LS, Nunley JA (1993) The management of soft<br />
tissue problems associated with calcaneal fractures.<br />
Clin Orthop 290: 151-160 [LoE 4]<br />
36. Lindvall E, Haidukewych G, DiPasquale T, Herscovici<br />
D, Jr., Sanders R (2004) Open reduction and stable<br />
fixation of isolated, displaced talar neck and body<br />
fractures. J Bone Joint Surg Am 86-A:2229-2234<br />
37. Main BJ, Jowett RL (1975) Injuries of the midtarsal<br />
joint. J Bone Joint Surg [Br] 57: 89-97 [LoE 4]<br />
38. Mainard D, Wepierre G, Cronier B, Delagoutte JP<br />
(1995) [Double use of sural fascio-cutaneous flap with<br />
distal pedicle to cover loss of substance of ankle or<br />
heel]. Rev Chir Orthop Reparatrice Appar Mot 80: 73-<br />
77 [LoE 4]<br />
39. Manoli A, Weber TG (1990) Fasciotomy of the foot: an<br />
anatomical study with special reference to release of<br />
the calcaneal compartment. Foot Ankle 10: 267-275<br />
[LoE 4]<br />
40. Manoli A, Fakhouri AJ, Weber TG (1993) Concurrent<br />
compartment syndromes of the foot and leg. Foot<br />
Ankle 14: 339 [LoE 4]<br />
41. May JW, Jr., Rohrich RJ (1986) Foot reconstruction<br />
using free microvascular muscle flaps with skin grafts.<br />
Clin Plast Surg 13: 681-689 [LoE 4]<br />
42. McCormack RG, Leith JM (1998) Ankle fractures in<br />
diabetics. Complications of surgical management. J<br />
Bone Joint Surg Br 80: 689-692<br />
43. McNamara MG, Heckman JD, Corley FG (1994).<br />
Severe open fractures of the lower extremity: a<br />
retrospective evaluation of the Mangled Extremity<br />
Severity Score (MESS). J Orthop Trauma 8:81-87 [LoE<br />
3]<br />
44. Menke H, Baumeister S, Erdmann D, Sauerbier M,<br />
Germann G (2000) Therapeutische Optionen zur<br />
Behandlung von Fersendefekten. Chirurg 71: 311-318<br />
[LoE 4]<br />
45. Metak G, Scherer MA, Dannohl C (1994) Übersehene<br />
Verletzungen des Stütz- und Bewegungsapparates beim<br />
<strong>Polytrauma</strong> – eine retrospective Studie. Zentralbl Chir<br />
119: 88-94 [LoE 4]<br />
46. Mittlmeier T, Machler G, Lob G, Mutschler W, Bauer<br />
G, Vogl T (1991) Compartment syndrome of the foot<br />
after intraarticular calcaneal fracture. Clin Orthop 269:<br />
241-248 [LoE 4]<br />
47. Mubarak SJ, Owen CA (1975) Compartmental<br />
syndrome and its relation to the crush syndrome: a<br />
spectrum of disease - a review of 11 cases of prolnged<br />
limb compression. Clin Orthop 113: 81-89 [LoE 4]<br />
48. Musharrafieh R, Osmani O, Saghieh S, El-Hassan B,<br />
Atiyeh B (1999) Microvascular composite tissue<br />
transfer for the management of type IIIB and IIIC<br />
fractures of the distal leg and compound foot fractures.<br />
J Reconstr Microsurg 15: 501-507 [LoE 4]<br />
49. Myerson MS, Fisher RT, Burgess AR, Kenzora JE<br />
(1986) Fracture dislocations of the tarsometatarsal<br />
joints: end results correlated with pathology and<br />
treatment. Foot Ankle 6: 225-242 [LoE 4]<br />
50. Myerson MS (1988) Experimental decompression of<br />
fascial compartments of the foot: the basis for<br />
fasciotomy in acute compartment syndromes. Foot<br />
Ankle 8: 308-314 [LoE 5]<br />
51. Myerson MS (1991) Management of compartment<br />
syndromes of the foot. Clin Orthop 271: 239 [LoE 5]<br />
52. Myerson MS (1999) Soft tissue trauma: acute and<br />
chronic management. In: Mann RA, Coughlin MJ eds)<br />
Surgery of the foot and ankle. Vol. II. Mosby, St Louis,<br />
1330-1372 [LoE 5]<br />
53. Patzakis MJ, Harvey JPJ, Ivler D (1974) The role of<br />
antibiotics in the management of open fractures. J Bone<br />
Joint Surg Am 56: 532-541 [LoE 1]<br />
54. Pisan M, Klaue K (1994) Compartment syndrome of<br />
the foot. Eur J Foot Ankle Surg 1: 29-36 [LoE 4]<br />
55. Rainer C, Schwabegger AH, Bauer T, et al. (1999) Free<br />
flap reconstruction of the foot. Ann Plast Surg 42: 595-<br />
606<br />
56. Rammelt S, Grass R, Brenner P, Zwipp H (2001)<br />
Septische Talusnekrose nach drittgradig offener<br />
Talusfraktur im Rahmen eines komplexen Fußtraumas<br />
(floating talus). Trauma Berufskrankh 3 (Suppl. 2):<br />
230-235 [LoE 5]<br />
57. Rammelt S, Grass R, Schikore H, Zwipp H (2002)<br />
Verletzungen des Chopart-Gelenks. Unfallchirurg 105:<br />
371-385 [LoE 5]<br />
58. Rammelt S, Barthel S, Biewener A, Gavlik JM, Zwipp<br />
H (2003) Calcaneusfrakturen. Offene Reposition und<br />
interne Stabilisierung. Zbl Chir 128: 517-528 [LoE 4]<br />
59. Rammelt S, Heineck J, Zwipp H. (2004) Metatarsal<br />
fractures. Injury 35 (2 Suppl): 77-86<br />
60. Rammelt S, Biewener A, Grass R, Zwipp H (2005)<br />
Verletzungen des Fußes beim polytraumatisierten<br />
Patienten. Unfallchirurg 108: 858-865 [LoE 5]<br />
61. Rammelt S, Schneiders W, Schikore H, Holch M,<br />
Heineck J, Zwipp H (2008) Primary open reduction and<br />
fixation compared with delayed corrective arthrodesis<br />
in the treatment of tarsometatarsal (Lisfranc) fracturedislocation.<br />
J Bone Joint Surg (Br) 90: 1499-1506 [LoE<br />
4]<br />
62. Rammelt S, Zwipp H (2009) Talar neck and body<br />
fractures. Injury 40: 120-135<br />
63. Randt T, Zwipp H (1997) <strong>Polytrauma</strong>: Indikation und<br />
Technik der Osteosynthese am Fuß. OP-Journal 13:<br />
192-198 [LoE 5]<br />
64. Randt T, Dahlen C, Schikore H, Zwipp H (1998)<br />
Luxationsfrakturen im Mittelfußbereich - Verletzungen<br />
des Chopart- und Lisfranc-Gelenkes. Zentralbl Chir<br />
123: 1257-1266 [LoE 4]<br />
65. Regel G, Lobenhoffer P, Lehmann U, Tscherne H<br />
(1993) Ergebnisse in der Behandlung<br />
<strong>Polytrauma</strong>tisierter. Eine vergleichende Analyse von<br />
3406 Fällen zwischen 1972 und 1991. Unfallchirurg<br />
96: 350-362 [LoE 5]<br />
66. Reigstad A, Hetland KR (1994) Free flap coverage in<br />
the reconstruction of foot injury. Acta Orthop Scand<br />
65: 103-106 [LoE 4]<br />
67. Russell WL, Sailors DM, Whittle TB, Fisher DF, Jr.,<br />
Burns RP (1991) Limb salvage versus traumatic<br />
amputation. A decision based on a seven-part<br />
predictive index. Ann Surg 213: 473-481 [LoE 2]<br />
68. Sanders R, Pappas J, Mast J, Helfet D (1992) The<br />
salvage of open grade IIIB ankle and talus fractures. J<br />
Orthop Trauma 6: 201-208 [LoE 4]<br />
Emergency surgery phase – Foot 410
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
69. Sanders R, Fortin P, DiPasquale A, Walling A, Helfet<br />
D, Ross E (1993) The results of operative treatment of<br />
displaced intra-articular calcaneal fractures using a CT<br />
scan classification. In: Tscherne H, Schatzker J eds)<br />
Major fractures of the pilon, the talus and the<br />
calcaneus. Springer Verlag, Berlin, Heidelberg, New<br />
York, 175-189<br />
70. Sangeorzan BJ, Benirschke SK, Mosca VEA (1989)<br />
Displaced intraarticular fractures of the tarsal navicular.<br />
J Bone Joint Surg (Am) 71: 1504-1510 [LoE 5]<br />
71. Sangeorzan BJ, Benirschke SK, Carr JB (1995)<br />
Surgical management of fractures of the os calcis. Instr<br />
Course Lect 44: 359-370 [LoE 5]<br />
72. Seiler H, Braun C, op den Winkel R, Zwank L (1986)<br />
Makro- und Mikroreplantationen an Unterschenkel und<br />
Fuß. Langenbecks Arch Chir 369: 625-627 [LoE 4]<br />
73. Siebert CH, Hansen M, Wolter D (1998) Follow-up<br />
evaluation of open intra-articular fractures of the<br />
calcaneus. Arch Orthop Trauma Surg 117: 442-447<br />
[LoE 4]<br />
74. Simpson AH, Deakin M, Latham JM (2001) Chronic<br />
osteomyelitis. The effect of the extent of surgical<br />
resection on infection-free survival. J Bone Joint Surg<br />
Br 83: 403-407 [LoE 3]<br />
75. Sirkin M, Sanders R, DiPasquale T, Herscovici D, Jr.<br />
(1999) A staged protocol for soft tissue management in<br />
the treatment of complex pilon fractures. J Orthop<br />
Trauma 13: 78-84 [LoE 4]<br />
76. Stiegelmar R, McKee MD, Waddell JP, Schemitsch EH<br />
(2001) Outcome of foot injuries in multiply injured<br />
patients. Orthop Clin North Am 32: 193-204 [LoE 5]<br />
77. Swiontkowski MF (1996) The multiply-injured patient<br />
with musculoskeletal injuries. In: Rockwood CA,<br />
Green DP, Bucholz RW eds) Fractures in adults. J B<br />
Lippincott, Philadelphia, 130-157 [LoE 5]<br />
78. Swiontkowski et al. (2002) J Trauma [LoE 2]<br />
79. Szyszkowitz R, Reschauer R, Seggl W (1985) Eightyfive<br />
talus fractures treated by ORIF with five to eight<br />
years of follow-up study of 69 patients. Clin Orthop<br />
199: 97-107<br />
80. Tennent T, Calder P, Salisbury R et al. (2001) The<br />
operative management of displaced intra-articular<br />
fractures of the calcaneum: a two-centre study using a<br />
defined protocol. Injury 32: 491-496 [LoE 4]<br />
81. Tscherne H, Oestern HJ (1982) Die Klassifizierung des<br />
Weichteilschadens bei offenen und geschlossenen<br />
Frakturen. Unfallheilkunde 85: 111-115<br />
82. Tscherne H (1986) Management der Verletzungen am<br />
distalen Unterschenkel und Fuß. Langenbecks Arch<br />
Chir 369: 539-542<br />
83. Tscherne H, Regel G, Sturm JA, Friedl HP (1987)<br />
Schweregrad und Prioritäten bei<br />
Mehrfachverletzungen. Chirurg 58: 631-640 [LoE 3]<br />
84. Turchin DC, Schemitsch EH, McKee MD, Waddell JP<br />
(1999) Do foot injuries significantly affect the<br />
functional outcome of multiply injured patients? J<br />
Orthop Trauma 13: 1-4 [LoE 2a]<br />
85. Vallier HA, Nork SE, Benirschke SK, Sangeorzan BJ<br />
(2003) Surgical treatment of talar body fractures. J<br />
Bone Joint Surg Am 85-A:1716-1724<br />
86. Vallier HA, Nork SE, Barei DP, Benirschke SK,<br />
Sangeorzan BJ (2004) Talar neck fractures: results and<br />
outcomes. J Bone Joint Surg Am 86-A:1616-1624 [LoE<br />
4]<br />
87. Whitesides TEJ, Haney TC, Morimoto K (1975) Tissue<br />
pressure measurements as a determinant for the need of<br />
fasciotomy. Clin Orthop 113: 43-51 [LoE 3]<br />
88. Yuksel F (2000) Replantation of an avulsive<br />
amputation of a foot after recovering the foot from the<br />
sea. Plast Reconstr Surg. 105: 1435-1437 [LoE 5]<br />
89. Zeligowski AA, Ziv I (1987) How to harvest skin graft<br />
from the avulsed flap in degloving injuries. Ann Plast<br />
Surg 19: 89-90 [LoE 4]<br />
90. Zwipp H, Scola E, Schlein U, Riechers D (1991)<br />
Verrenkungen der Sprunggelenke und der Fußwurzel.<br />
Hefte Unfallheilkunde 220: 81-82 [LoE 5]<br />
91. Zwipp H, Tscherne H, Thermann H, Weber T (1993)<br />
Osteosynthesis of displaced intraarticular fractures of<br />
the calcaneus. Results in 123 cases. Clin Orthop. 290:<br />
76-86 [LoE 4]<br />
92. Zwipp H (1994) Chirurgie des Fußes. Springer-Verlag,<br />
Wien - New York [LoE 5]<br />
93. Zwipp H, Dahlen C, Randt T, Gavlik JM (1997)<br />
Komplextrauma des Fußes. Orthopäde 26: 1046-1056<br />
[LoE 5]<br />
94. Zwipp H, Rammelt S (2002) Frakturen und Luxationen.<br />
In: Wirth CJ, Zichner, L. (eds.): Orthopädie und<br />
Orthopädische Chirurgie. Vol. 8. Georg Thieme<br />
Verlag, Stuttgart, New York, 531-618 [LoE 5]<br />
95. Zwipp H, Rammelt S, Barthel S. Kalkaneusfraktur.<br />
Unfallchirurg 108: 737-748, 2005 [LoE 5]<br />
96. Zwipp H, Sabauri G, Amlang M (2008) Zur<br />
chirurgischen Behandlung des Pes equino varus als<br />
Folge eines Kompartment- und /oder<br />
Postischämiesyndromes der tiefen Flexorenloge des<br />
Unterschenkels. Unfallchirurg [LoE 4]<br />
Emergency surgery phase – Foot 411
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.12 Mandible and midface<br />
Securing the airways; bleeding<br />
Key recommendation:<br />
In mandible and maxillofacial injuries, primary securing of the airways and<br />
hemostasis in the oral and maxillofacial region must be carried out.<br />
Explanation:<br />
GoR A<br />
The immediate securing of the airways and management of intense bleeding are vital to life [44].<br />
There is often a danger of suffocation due to foreign bodies (e.g., dental prostheses, tooth and<br />
bone fragments, blood clots, mucus, vomit). This danger should be eliminated by manually<br />
cleaning the oral cavity and the throat and by suctioning the deeper airways [2]. If there is<br />
instability in the mandible as a result of comminutions or erosion of the middle piece, this can<br />
cause the tongue to fall back and displace the airways. The hazardous situation can be remedied<br />
by reduction and stabilization of the mandible with wire ligatures attached to available teeth [2].<br />
If the airways in the craniocervical region are disabled by intense bleeding, tongue swelling and<br />
displacement, then intubation, a tracheotomy or coniotomy (cricothyroidotomy) is necessary<br />
depending on the urgency and feasibility [3, 28].<br />
If larger vessels are affected (generally the origins of the external carotid artery), surgical<br />
hemostasis will be necessary. Open surgical hemostasis with vascular ligation and bipolar<br />
electrocoagulation or embolization with angiography is recommended [16, 18, 28]. The exact<br />
source of bleeding should be located for effective hemostasis [38]. Epistaxis is one of the<br />
commonest types of bleeding. Most bleeding can be arrested by primary compression using<br />
tamponades [26, 40]. In the case of persistent bleeding in the nasopharyngeal space, it is<br />
necessary to insert Bellocq packing or a balloon catheter [15]. In the case of bleeding from the<br />
maxillofacial region, particularly the maxillary artery, an attempt can be made to arrest the<br />
bleeding by compressing the maxilla dorsocranially against the base of the skull (e.g., spatula<br />
head bandage, dental impression tray with extraoral brace) [2]. In the case of sagittal maxillary<br />
fractures, compression can be necessary, e.g., by a transverse wire suture from the molars on one<br />
side to the molars on the contralateral side [2, 37]. Reduction and fixing of craniofacial fractures<br />
often represent the best causal treatment even for severe hemorrhages [15].<br />
Emergency surgery phase – Mandible and midface 412
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Soft tissue facial injuries<br />
Key recommendation:<br />
Soft tissue injuries should be managed during the emergency surgery phase. GoR B<br />
Explanation:<br />
Injuries to the facial soft tissues occur either isolated in the form of abrasion, gash, cuts, crush,<br />
and defect wounds or in severe trauma in combination with craniofacial fractures. Gash and<br />
crush wounds are the commonest facial soft tissue injuries [43]. Soft tissue injuries, particularly<br />
those with exposed cartilage and/or bone surfaces, for example, should be managed at the<br />
earliest opportunity. Ideally, this can take place in the emergency room [20]. Rapid management<br />
of soft tissue injuries also contributes towards achievement of improved esthetic and functional<br />
outcomes [5, 17, 27, 31, 41, 45].<br />
Appropriate hemostasis and cerebral decompression if there is intracranial pressure are the most<br />
important principles in the first hours after the trauma [24]. Craniofacial and soft tissue injuries<br />
are managed in the secondary phase [42]. In the case of combined soft tissue injuries with<br />
craniofacial fractures, definitive soft tissue management should be carried out after<br />
reconstruction of the bony structures if possible (“from inside to outside”) [22]. Functional<br />
structures such as eyelids, lips, the facial nerve, and the parotid gland should be reconstructed<br />
during primary wound management [39]. Gently cleansing the wound and removing foreign<br />
bodies should be carried out before reconstructive graft work so that good esthetic and functional<br />
results can be achieved later [21]. Bigger reconstructive measures or microvascular<br />
reconstructions are generally undertaken in two steps [32].<br />
Tooth injuries, alveolar process fractures<br />
Key recommendation:<br />
The goal should be immediate management, if necessary rapid management of<br />
the tooth-alveolar process trauma.<br />
Explanation:<br />
GoR B<br />
The treatment goal for tooth injuries and alveolar process fractures consists of restoring shape<br />
and function (esthetics, occlusion, articulation, phonation). This entails attempting to salvage<br />
both the tooth structure and the alveolar process.<br />
The treatment depends on the general salvage worth and vitality of the teeth [1].<br />
The prognosis for preserving a tooth long-term after avulsion depends on the l<strong>eng</strong>th of time and<br />
storage of the tooth (e.g., cell culture medium/Dentosafe, cold milk, physiologic saline solution,<br />
oral cavity) until successful replantation [9, 10]. The most favorable replantation results can be<br />
Emergency surgery phase – Mandible and midface 413
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
achieved within the first 30 minutes [46]. Avulsed teeth, which have been preserved dry for<br />
several hours, have the most unfavorable prognosis although successful replantations have also<br />
been reported in individual case reports. For this reason, a replantation attempt after a longer<br />
interval can also be justified in individual cases [13].<br />
Management of alveolar process fractures should also be undertaken at the earliest opportunity<br />
[6, 46].<br />
Acute treatment should be carried out within a few hours for extrusion, lateral dislocation or<br />
avulsion of a tooth, an alveolar process fracture or a root fracture [1, 6]. Careful handling of the<br />
periodontal ligament and swift fixation via splints or splint bandaging protect from infections<br />
and permanent tooth loss [9, 10, 48].<br />
Managing complicated crown fractures after 3 hours and uncomplicated crown fractures with<br />
exposed dentine after 48 hours worsen the prognosis of vital teeth [6].<br />
Mandible and midface<br />
Key recommendation:<br />
Depending on the overall injury severity, maxillofacial and mandible fractures<br />
can be managed in the emergency surgery phase or secondary phase.<br />
Explanation:<br />
GoR 0<br />
The treatment goal consists of restoring shape and function. Particular value is placed on<br />
restoring occlusion, articulation, joint function, esthetics, and motor and/or sensory nerve<br />
function. Treatment strategies, surgery techniques, and procedure are comparable with those for<br />
isolated fractures or combination fractures of the mandible and/or midface.<br />
Ideally, maxillofacial and mandible fractures receive one-step early primary management [7, 36].<br />
In maxillofacial fractures, early management with anatomic reduction and fixation led to a<br />
reduction in edema formation and better recontouring of the facial soft tissues [12, 23, 34].<br />
However, the timing was very imprecisely stated by the authors with “immediately” or “within<br />
the first few days”. Bos et al. [4] require surgical management of maxillofacial fractures with<br />
open reduction and fixation within 48-72 hours in order to achieve a good esthetic and functional<br />
outcome and to avoid secondary corrections. Better reduction of bone fragments and faster<br />
healing and thus also more favorable esthetic results were observed in children with<br />
maxillofacial fractures who were operated on within a week after trauma [19].<br />
With reference to a concomitant traumatic brain injury (TBI), the Glasgow Coma Scale (GCS)<br />
provides valuable information on the prognosis of the injured person. However, this does not<br />
mean that patients with a low GCS have to be automatically excluded from management of<br />
craniofacial fractures. Manson [23] reports that patients with head injuries can undergo surgery<br />
without increased complication rates provided that the intracranial pressure is kept below a value<br />
of 25 mmHg during the intervention. In a retrospective study on 49 patients with mandible<br />
and/or maxillofacial fractures with additional traumatic brain injury, Derdyn et al. [8] observed<br />
Emergency surgery phase – Mandible and midface 414
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
that patients with intracranial pressure below 15 mmHg after early surgical management (0-<br />
3 days after the accident) had comparable survival rates to comparison groups after medium-term<br />
(4-7 days) or later (> 7 days) surgical management. There were no significant differences in<br />
postoperative complications between the comparative patient collectives receiving early,<br />
medium-term, and late surgery. In contrast, craniofacially-injured patients with low GCS,<br />
intracranial bleeding, and shift in median brain structures after lateral and multisystem trauma<br />
had a significantly worse prognosis.<br />
Due to improvements in functional and esthetic outcomes through the use of mini- and<br />
microplates and by less invasive surgical techniques [14], early management within 24-72 hours<br />
is becoming increasingly controversial.<br />
If higher priority is given to the general condition or other injuries, then the definitive<br />
management of craniofacial injuries can be postponed by 7-10 days after the trauma event after<br />
management of soft tissue injuries and temporary stabilization (e.g., with splint bandaging, wire<br />
ligatures, splints) of fractures [7]. Ideally, soft tissue management and temporary stabilizations<br />
can take place in the emergency room [20].<br />
In a retrospective study with comparable groups on a total of 82 multiply injured patients with<br />
mandible and/or maxillofacial fractures, Weider et al. [47] showed that delayed management<br />
(≥ 48 hours) did not lead to any extension in treatment time in the intensive care unit and in<br />
hospitalization. The infection rate was negligible and the complication rate comparable with that<br />
of patients who had been operated on within 48 hours. Schettler [35] did not observe any<br />
disadvantages in definitive management of maxillofacial fractures within 14 days. Neither<br />
infections nor residual disorders in eye motility were observed to a greater extent compared to<br />
immediate treatment. On the other hand, after the initial severe edema subsided, the complicated<br />
rejoining of even the smallest bone fragments was much easier to carry out. He regards the most<br />
favorable timing for definitive management as between the 5th and 10th day after the trauma.<br />
Kühne et al. [20] retrospectively analyzed a total of 78 patients with mandible and/or<br />
maxillofacial fractures who received surgery in the emergency room. There was a comparatively<br />
identical postoperative complication rate among the patients who received early primary (within<br />
72 hours) or delayed (after 72 hours) surgery. The group of patients who received delayed<br />
surgery had a markedly higher overall injury severity than those who received early primary<br />
management.<br />
Exceptions for delayed management are non-arrestable bleeding from fractures which require<br />
immediate reduction and osteosynthesis, and intraorbital or intracranial damage to the optic<br />
nerve, which necessitates therapeutic action within a few hours [7]. Retrobulbar hematomas,<br />
elevated eye pressure or direct compression on the optic nerve secondary to vision deterioration<br />
can necessitate the immediate introduction of a megadose of cortisone treatment over 48 hours<br />
(30 mg Urbason/kg BW i. v. as bolus and 5.4 mg Urbason/kg BW hourly over the following 47<br />
hours) and/or immediate surgical decompression of the optic nerve [7, 11, 30, 46].<br />
In injuries covering several disciplines, the appropriate specialist disciplines must be involved in<br />
the treatment planning and treatment [25]. Depending on the injury severity, the sequence of<br />
measures to be taken should be established on an interdisciplinary basis [20, 25, 47].<br />
Emergency surgery phase – Mandible and midface 415
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Andreasen JO, Andreasen FM, Bakland LK, Flores<br />
MT: Traumatic dental injuries. Blackwell<br />
Munksgaard, Copenhagen, 2003 [LoE 4]<br />
2. Austermann KH: Frakturen des Gesichtsschädels. In:<br />
Schwenzer N und Ehrenfeld M.: Zahn-Mund-Kiefer-<br />
Heilkunde, Band 2: Spezielle Chirurgie. Georg<br />
Thieme Verlag, Stuttgart, New York, 275-366, 2002<br />
[LoE 5]<br />
3. Bootz F: Immediate management of rupture and soft<br />
tissue injuries the area of head and neck. HNO 41(11):<br />
542-52, 1993 [LoE 4]<br />
4. Bos RR, Jansma J, Vissink A: Fractures of the<br />
midface. Ned Tijdschr Tandheelkd. 104(11): 440-443,<br />
1997 [LoE 5]<br />
5. Bruce D: Craniofacial trauma in children. J<br />
Craniomaxillofac Trauma 1(1): 9-19, 1995 [LoE 4]<br />
6. Dale RA: Dentoalveolar trauma. Emerg Med Clin<br />
North Am 18(3): 411-48, 2000 [LoE 4]<br />
7. Dempf HP, Hausamen JE: Gesichtsschädelfrakturen.<br />
Unfallchirurg 103: 301-13, 2000 [LoE 5]<br />
8. Derydn C, Persing JA, Broaddus WC, Delashaw JB,<br />
Jane M, Levine PA, Torner J: Craniofacial trauma: an<br />
assessment of risk related to timing of surgery. Plast<br />
Reconstr Surg 86: 238-45, 1990 [LoE 2]<br />
9. Flores MT, Andersson L, Andreasen JO, Bakland LK,<br />
Malmgren B, Barnett F, Bourguignon C, DiAngelis A,<br />
Hicks L, Sigurdsson A, Trope M, Tsukiboshi M, von<br />
Arx T: Guidelines for the management of traumatic<br />
dental injuries. I. Fractures and luxations of<br />
permanent teeth. Dent Traumatol 23(2): 66-71, 2007a<br />
[Evidenzbasierte Leitlinie]<br />
10. Flores MT, Andersson L, Andreasen JO, Bakland LK,<br />
Malmgren B, Barnett F, Bourguignon C, DiAngelis A,<br />
Hicks L, Sigurdsson A, Trope M, Tsukiboshi M, von<br />
Arx T: Guidelines for the management of traumatic<br />
dental injuries. II. Avulsion of permanent teeth. Dent<br />
Traumatol 23(3): 130-36, 2007b [Evidenzbasierte<br />
Leitlinie]<br />
11. Gellrich NC, Gellrich MM, Zerfowski M, Eufinger H,<br />
Eysel UT: Clinial and experimental study on<br />
traumatic optic nerve demage. Der Ophthalmologe ,<br />
94(11): 807-14, 1997 [LoE 4]<br />
12. Gruss JS: Complex craniomaxillofacial trauma:<br />
evolving concepts in management: a trauma unit‘s<br />
experience – 1989 Fraser B. Gurd Lecture. J Trauma<br />
30: 377-83, 1990 [LoE 5]<br />
13. Gutwald R, Gellrich NC, Schmelzeisen R. Einfürung<br />
in die zahnärztliche Chirurgie. Urban&Fischer Verlag,<br />
München, Jena, 191-203, 2003 [LoE 4]<br />
14. Hartel J, Hoppe H (1991) Erfolgsrate in der<br />
Behandlung von Mittelgesichtsfrakturen. Dtsch Z<br />
Mund Kiefer Gesichts Chir 15: 111–115, 1991 [LoE<br />
4]<br />
15. Hausamen JE, Schmelzeisen R: Behandlung von<br />
Blutungen im Kiefer- und Gesichtsbereich.<br />
Langenbecks Arch Chir Suppl (Kongressbericht),<br />
333-337, 1993 [LoE 4]<br />
16. Heymans O, Nelissen X, Gilon Y, Damme HV,<br />
Flandroy P: Vascular complications after cranio-facial<br />
trauma. Rev Stomatol Chir Maxillofac 103(5): 281-7,<br />
2002 [LoE 4]<br />
17. Jones WD 3rd, Whitaker LA, Murtagh F:<br />
Applications of reconstructive craniofacial techniques<br />
to acute craniofacial trauma. J Trauma 17(5): 339-43,<br />
1977 [LoE 4]<br />
18. Kirichenko MN, Mosunov AI, Bronnikov NM,<br />
Astakhov SI: Surgical treatment of blood vessel<br />
injuries in a trauma center. Vestn Khir Im I I Grek<br />
131(10): 88-91, 1983 [LoE 4]<br />
19. Kos M, Luczak K, Godzinski J, Rapala M, Klempours<br />
J: Midfacial fractures in children. Eur J Pediatr Surg<br />
12 (4): 218-225, 2002 [LoE 3]<br />
20. Kühne CA, Krueger C, Homann M, Mohr C,<br />
Ruchholtz S: Mund Kiefer Gesichtschir 11(4): 201-8,<br />
2007 [LoE 3]<br />
21. Leach J: Propper handling of soft tissue in the acute<br />
phase. Facial Plast Surg 17(4): 227-238, 2001 [LoE 4]<br />
22. Lewandowski B, Brodowski R, Blajer P: Primary<br />
management of facial skeleton injuries in patients<br />
treated at the maxillofacial surgery ward. Pol<br />
Merkuriusz Lek 8(45): 136-140, 2000 [LoE 2]<br />
23. Manson PN: Management of facial fractures. Perspect<br />
Plast Surg 2:1, 1988 [LoE 5]<br />
24. Marzi I, Mutschler W: Strategie der operativen<br />
Versorgung des <strong>Polytrauma</strong>s. Zentralbl Chir 121<br />
(11): 950-962, 1996 [LoE 4]<br />
25. Mathiasen RA, Eby JB, Jarrahy R, Shahinian HK,<br />
Margulies DR: A dedicated craniofacial trauma team<br />
improves efficiency and reduces cost. J Surg Res<br />
97(2): 138-43, 2001 [LoE 2]<br />
26. McGarry GW, Moulton C: The first aid management<br />
of epistaxis by accident and emergency department<br />
staff. Arch Emerg Med 10(4): 298-300, 1993 [LoE 4]<br />
27. Merville LC, Diner PA, Blomgren I: Craniofacial<br />
trauma. World J Surg 13(4): 419-39, 1989 [LoE 4]<br />
28. Perry M, O'Hare J, Porter G: Advanced Trauma Life<br />
Support (ATLS ® ) and facial trauma: can one size fit<br />
all? Part 3: Hypovolaemia and facial injuries in the<br />
multiply injured patient. Int J Oral Maxillofac Surg<br />
37(5): 405-14, 2008 [LoE 3]<br />
29. Perry M, Morris C: Advanced Trauma Life Support<br />
(ATLS ® ) and facial trauma: can one size fit all? Part<br />
2: ATLS ® , maxillofacial injuries and airway<br />
management dilemmas. Int J Oral Maxillofac Surg<br />
37(4): 309-20, 2008<br />
30. Perry M, Moutray T: Advanced Trauma Life Support<br />
(ATLS ® ) and facial trauma: can one size fit all? Part<br />
4: 'can the patient see?' Timely diagnosis, dilemmas<br />
and pitfalls in the multiply injured, poorly<br />
responsive/unresponsive patient. Int J Oral Maxillofac<br />
Surg 37(6): 505-14, 2008 [LoE 3]<br />
31. Robotti E, Forcht Dagi T, Ravegnani M, Bocchiotti G:<br />
A new prospect on the approach to open, complex,<br />
craniofacial trauma. J Neurosurg Sci 36(2): 86-99,<br />
1992 [LoE 4]<br />
32. Rodriguez ED, Martin M, Bluebond-Langner R,<br />
Khalifeh M, Singh N, Manson PN: Microsurgical<br />
reconstruction of posttraumatic high-energy maxillary<br />
Emergency surgery phase – Mandible and midface 416
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
defects: establishing the effectiveness of early<br />
reconstruction. Plast Reconstr Surg 120(7 Suppl 2):<br />
103S-17S, 2007 [LoE 4]<br />
33. Sackett DL, Richardson WS, Rosenberg W, Haynes<br />
RB: Evidence-based medicine: How to practice and<br />
teach EBM. Churchill Livingstone, London, 1997<br />
34. Sargent LA, Rogers GF: Nasoethmoid orbital<br />
fractures: Diagnosis and management. J<br />
Craniomaxillofac Trauma 5 (1): 19-27, 1999 [LoE 5]<br />
35. Schettler D: Zeitpunkt der definitiven Versorgung<br />
schwerer Orbita- und Mittelgesichtsverletzungen.<br />
Fortschr Kiefer Gesichtschir 36: 39-41, 1991 [LoE 4]<br />
36. Schierle HP, Hausamen JE: Moderne Prinzipien in der<br />
Behandlung komplexer Gesichtsschädelverletzungen.<br />
Unfallchirurg 100: 330-7, 1997 [LoE 5]<br />
37. Schubert J: Wundlehre. In Schwenzer N, Ehrenfeld<br />
M: Zahn-Mund-Kiefer-Heilkunde, Band 1:<br />
Allgemeine Chirurgie, Georg Thieme Verlag,<br />
Stuttgart, New York, 1-26, 2000 [LoE 5]<br />
38. Sparacino <strong>LL</strong>: Epistaxis management: what´s new and<br />
what´s noteworthy. Lippincotts. Prim Care Pract 4(5):<br />
498-507, 2000 [LoE 4]<br />
39. Spauwen PH: Soft tissue injuries of the face. Ned<br />
Tijdschr Tandheelkd 104 (11): 421-424, 1997 [LoE 4]<br />
40. Strachan D, England J: First-aid treatment of<br />
epistaxis-confirmation of widespread ignorance.<br />
Postgrad Med J 74(868): 113-4, 1998 [LoE 4]<br />
41. Stranc MF, Harrison DH: Primary treatment of<br />
craniofacial injuries. Rev Stomatol Chir Maxillofac<br />
79(5): 363-71, 1978 [LoE 4]<br />
42. Tscherne H, Regel G, Pape HC, Pohlemann T, Krettek<br />
C: Internal fixation of multiple fractures in patients<br />
with polytrauma. Clin Orthop (347): 62-78, 1998<br />
[LoE 4]<br />
43. Tu Ah, Girotto JA, Singh N, Dufresne CR, Robertson<br />
BC, Seyfer AE, Manson PN, Iliff N: Facial fractures<br />
from dog bite injuries. Plast Reconstr Surg 109(4):<br />
1259-65, 2002 [LoE 4]<br />
44. Tung TC, Ts<strong>eng</strong> WS, Chen CT, Lai JP, Chen YR:<br />
Acute life-threatening injuries in facial fracture<br />
patients: a review of 1,025 patients. J Trauma 49(3):<br />
420-4, 2000 [LoE 4]<br />
45. Vigneul JC, Le Flem P, Princ G: Craniofacial trauma.<br />
Value and methods of early treatment 70 cases. Rev<br />
Stomatol Chir Maxillofac 80(5): 280-98, 1979 [LoE<br />
3]<br />
46. Ward Booth P, Eppley LB, Schmelzeisen R:<br />
Maxillofacial trauma and esthetic facial<br />
reconstruction. Elsevier Science, Churchill<br />
Livingstone, London, 2003 [LoE 4]<br />
47. Weider L, Hughes K, Ciarochi J, Dunn E: Early<br />
versus delayed repair of facial fractures in the<br />
multiply injured patient. Am Surg 65: 790–793, 1993<br />
[LoE 2]<br />
48. Yang D, Shi Z: Clinical retrospect on<br />
autoimplantation of traumatically dislocated teeth.<br />
Hua Xi Kou Qiang Yi Xue Za Zhi, 2000 [LoE 4]<br />
Emergency surgery phase – Mandible and midface 417
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
3.13 Neck<br />
Key recommendations:<br />
Provided no intubation or tracheotomy has been carried out beforehand, all<br />
findings related to the airways must be examined and assessed before<br />
induction of intubation anesthesia.<br />
Intubation aids and a coniotomy set must be kept immediately available.<br />
Difficult airway algorithms must be heeded here.<br />
A coniotomy carried out previously must be surgically closed; if necessary, a<br />
tracheotomy must be carried out.<br />
Penetrating trauma to the esophagus should undergo primary reconstructive<br />
treatment within 24 hours.<br />
Explanation:<br />
GoR A<br />
GoR A<br />
GoR A<br />
GoR B<br />
If the upper airways are involved in a polytrauma, intubation difficulties from swelling,<br />
displacement and/or secretion and blood are to be expected.<br />
In the case of tracheal tears or avulsions or open tracheal injuries, surgical exploration with<br />
insertion of a tracheostoma or direct reconstruction is recommended [1]. The same applies to<br />
trauma in the region of the larynx.<br />
There is controversy surrounding conservative treatment of tracheal tears. Conservative<br />
treatment can be considered for non-gaping, short-segment lesions that can be bridged by the<br />
tube [3]. The majority of studies argue in favor of surgical reconstruction at the earliest<br />
opportunity via transcervical approach, thoracotomy or, as an exception, a transcervicaltranstracheal<br />
approach. The single-layer suture with absorbable material and single knot sutures<br />
is recommended [1, 2, 4–7]. The decision must be made on a case-by-case basis as to whether a<br />
tracheotomy in the conventional sense, in other words an epithelized tracheostoma, or a puncture<br />
tracheotomy is used. On the one hand, the exclusion criteria for a puncture tracheotomy must be<br />
heeded and, on the other hand, the risk of iatrogenic injury to adjacent structures [5]. The fact<br />
that cannula replacement is simpler is a particular advantage of the epithelized tracheostoma. In<br />
laryngeal trauma, attempts should be made to effectuate early reconstruction. There are no<br />
literature sources to be found which focus on a purely conservative treatment of laryngeal trauma<br />
[1, 2, 4–7], particularly against the background of preventing stenoses and voice disorders. In<br />
addition to removing stenoses and covering cartilage defects, the insertion of indwelling<br />
laryngeal stents for several weeks is recommended in order to prevent stenoses, strictures, and<br />
webbing [2, 4, 5].<br />
An elective tracheotomy should be considered if ventilation treatment is expected to continue<br />
longer. Historical studies have shown that, even after 48 hours, orotracheal intubation can lead to<br />
Emergency surgery phase – Neck 418
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
irreversible damage to the larynx and tracheal cartilage with blood pressure, tube materials, and<br />
the use of vasoactive substances being important determinants. The main critical place is the<br />
cricoid cartilage; using modern cuffs (low-pressure high-volume), the risk of a tracheal stenosis<br />
can be lowered with simultaneous monitoring of the cuff pressure. Early tracheotomy thus serves<br />
primarily to prevent cricoid cartilage stenosis.<br />
Damage to the recurrent laryngeal nerve or the vagus nerve can be most easily detected by<br />
evaluating vocal cord mobility using a laryngoscope (direct and indirect) or stroboscope. There<br />
is no evidence in the literature for emergency surgical treatment for a suspected recurrent paresis<br />
as part of polytrauma. Here, the focus is on confirming airway stenosis possibly caused by<br />
posttraumatic vocal cord paralysis. No studies have been found on traumatically induced<br />
laryngeal paralysis. The conclusions are based on postoperative pareses after struma surgery.<br />
Here, contradictory successes in surgical decompressions and reconstructions are reported. A<br />
noticeable improvement in the situation for the patient cannot be deduced from the literature.<br />
Following on from the endoscopic functional diagnostic study (laryngoscopy/stroboscopy),<br />
imaging procedures such as computed tomography can provide evidence on the location of the<br />
damage [9, 10].<br />
As an alternative to surgery, conservative treatment using antibiotic protection can be considered<br />
for localized perforations lying in the cervical section of the esophagus [11]. According to case<br />
series, a direct suture of all layers within the first 24 hours offers the best prognosis for the<br />
clinical course [12, 13]. According to the literature, intrathoracic esophageal injuries should<br />
always undergo surgical treatment; no studies have been found which support conservative<br />
treatment. For esophageal perforations not accessible by direct suture, partial resections, if<br />
necessary with interposition grafts, are recommended [12-18]; alternatively, an endoluminal<br />
bond with fibrin adhesive can be considered. With all these recommendations, it should be noted<br />
that no clinical studies have been found, only case series and individual reports.<br />
This should be carried out as surgical reconstruction, if necessary with interposition grafts of the<br />
arterial vessels. However, injuries not occluding the lumen can also be treated conservatively<br />
(e.g., dissections). A reconstruction of venous vessels must not be carried out/is not indicated.<br />
Angiography, computed tomography and duplex or Doppler ultrasonography represent the first<br />
line choice of examination procedures for injuries to the neck vessels [21]; this applies without<br />
restriction in zones I and III according to Roon and Christensen [23]. Surgical exploration is<br />
additionally recommended for zone II. Although this is hotly debated in the literature, it is not in<br />
dispute that 100% of defects can be detected by this method and if necessary treated [21, 23].<br />
The largest clinically controlled study is by Weaver et al. [24] and comes to the conclusion that<br />
reconstructions of arterial vessels offer the best outcome for penetrating injuries. The restoration<br />
of arterial vessels must be carried out within a timeframe of 120 minutes [20]. However, injuries<br />
not occluding the lumen can be treated conservatively with success by duplex ultrasonography<br />
monitoring [24].<br />
In addition to a surgical intervention, there is also the possibility of neuroradiologic endovascular<br />
treatment for pseudoaneurysms or fistulas [19]. No studies have been found that support<br />
reconstruction of injured venous vessels [22].<br />
Emergency surgery phase – Neck 419
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
References<br />
1. Dienemann H, Hoffmann H (2001). Tracheobronchial<br />
injuries and fistulas. Chirurg 72 (2001): 1131-1136<br />
2. Donald PJ. Trachealchirurgie: Kopf – und Hals<br />
Chirurgie (H.H. Naumann et al) 1998 Georg Thieme<br />
Verlag (S. 243 - 57)<br />
3. Gabor S, Renner H, Pinter H, Sankin O, Maier A,<br />
Tomaselli F, Smolle Juttner FM. Indications for<br />
surgery in tracheobronchial ruptures. Eur J<br />
Cardiothorac Surg 20 (2001): 399-404<br />
4. Pitcock, J. Traumatologie der Halsweichteile: Kopf –<br />
und Hals Chirurgie (H.H. Naumann et al) 1998 Georg<br />
Thieme Verlag (S. 459 - 75)<br />
5. Welkoborsky HJ. Verletzungen der Halsregion und<br />
der Halswirbelsäule. Praxis der HNO – Heilkunde,<br />
Kopf- und Halschirurgie (J. Strutz, W. Mann) 2010<br />
Georg Thieme Verlag<br />
6. Hwang SY, Yeak SC. Management dilemmas in<br />
laryngeal trauma. J Laryngol Otol 118 (2004) 325-328<br />
7. Bell RB, Verschueren DS, Dierks, EJ. Management of<br />
laryngeal trauma. Oral Maxillofac Surg Clin N Am 20<br />
(2008) 415-430.<br />
8. Robinson S, Juutilainen M, Suomalainen A.<br />
Multidetector row computed tomography of the<br />
injured larynx after trauma. Semin Ultrasound CT MR<br />
30 (2009) 188-194<br />
9. Thermann M, Feltkamp M, Elies W, Windhorst T.<br />
Recurrent laryngeal nerve paralysis after thyroid gland<br />
operations. Etiology and consequences. Chirurg. 1998<br />
Sep;69(9):951-6<br />
10. Welkoborsky HJ. Verletzungen der Halsregion und<br />
der Halswirbelsäule. Praxis der HNO – Heilkunde,<br />
Kopf- und Halschirurgie (J. Strutz, W. Mann) 2010<br />
Georg Thieme Verlag<br />
11. Demetriades D, Velmahos GG, Asensio JA. Cervical<br />
pharyngoesophageal and laryngotracheal injuries.<br />
World . J Surg 25 (2001): 1044-1048.<br />
12. Eroglu A, Can Kurkcuogu I, Karaoganogu N,<br />
Tekinbas C, Yimaz O, Basog M. Esophageal<br />
perforation: the importance of early diagnosis and<br />
primary repair. Dis Esophagus. 17 (2004): 91-94<br />
13. Kotsis L, Kostic S, Zubovits K. Multimodality<br />
treatment of esophageal disruptions. Chest. 112<br />
(1997): 1304-1309<br />
14. Lamesch P, Dralle H, Blauth M, Hauss J, Meyer<br />
HJ.Perforation of the cervical esophagus after ventral<br />
fusion of the cervical spine. Defect coverage by<br />
muscle-plasty with the sternocleidomastoid muscle:<br />
case report and review of the literature. Chirurg 68<br />
(1997): 543-547.<br />
15. Mai C, Nagel M, Saeger HD. Surgical therapy of<br />
esophageal perforation. A determination of current<br />
status based on 4 personal cases and the literature.<br />
Chirurg 68 (1997): 389-394<br />
16. Pitcock, J. Traumatologie der Halsweichteile. Kopf –<br />
und Hals Chirurgie (H.H. Naumann et al) 1998 Georg<br />
Thieme Verlag (S. 459 - 475).<br />
17. Strohm PC, Muller CA, Jonas J, Bahr R. Esophageal<br />
perforation. Etiology, diagnosis, therapy. Chirurg<br />
73(2002): 217-222<br />
18. Sung SW, Park JJ, Kim YT, Kim JH. Surgery in<br />
thoracic esophageal perforation: primary repair is<br />
feasible. Dis Esophagus 15(2002): 204-209<br />
19. Diaz-Daza O, Arraiza FJ, Barkley JM, Whigham CJ.<br />
Endovascular therapy of traumatic vascular lesions of<br />
the head and neck. Cardiovasc Intervent Radiol 26<br />
(2003): 213-221.<br />
20. Etl S, Hafer G, Mundinger A. Cervical vascular<br />
penetrating trauma. Unfallchirurg 103 (2000): 64-67.<br />
21. Ginzburg E, Montalvo B, LeBlang S, Nunez D,<br />
Martin L. The use of duplex ultrasonography in<br />
penetrating neck trauma. Arch Surg. 131 (1996): 691-<br />
693.<br />
22. Pitcock J. Traumatologie der Halsweichteile Kopf –<br />
und Hals Chirurgie (H.H. Naumann et al) 1998 Georg<br />
Thieme Verlag (S. 459 - 475).<br />
23. Roon AJ, Christensen N. Evaluation and treatment of<br />
penetrating cervical injuries. J Trauma 19 (1979):<br />
391-397<br />
24. Weaver FA, Yellin AE, Wagner WH, Brooks SH,<br />
Weaver AA, Milford MA. The role of arterial<br />
reconstruction in penetrating carotid injuries. Arch<br />
Surg 123(1988): 1106-1111.<br />
Emergency surgery phase – Neck 420
<strong>S3</strong> Guideline on Treatment of Patients with Severe and Multiple Injuries<br />
Date published: 2002<br />
Date revised: July 2011<br />
Next revision planned for: December 2014<br />
The “guidelines” of the Scientific Medical Societies are systematically developed aids for<br />
physicians in decision-making in specific situations. Based on current scientific knowledge<br />
and on procedures proven in practice, they ensure a greater degree of safety in medicine yet<br />
are also intended to cover economic aspects. The “guidelines” are not legally binding for<br />
physicians and therefore neither substantiate liability nor exempt from liability.<br />
The AWMF compiles and publishes the guidelines of the medical societies with the utmost<br />
care. Notwithstanding, the AWMF accepts no responsibility for the accuracy of the content.<br />
For information on dosages, in particular, the manufacturer’s data should always be heeded.<br />
©Deutsche Gesellschaft für Unfallchirurgie<br />
Authorized for electronic publication: AWMF online<br />
Emergency surgery phase 421