| Matt Barkley rush for no gain to the Ind20.4th 01:19 | | |
| Matt Barkley rush for a loss of 1 yard to the Ind20.4th 02:00 | | |
| Jordan Mims rush to the left for 4 yards to the Ind19. Tackled by Donavan Mutin.4th 02:11 | | |
| Jordan Mims rush to the left for 9 yards to the Ind23. Tackled by Aaron Maddox and Grant Stuard.4th 02:56 | | |
| Colts timeout.4th 02:56 | | |
| Matt Barkley pass to the middle to Tyrell Shavers for 16 yards to the Ind32. Tackled by Isaac Taylor-Stuart.4th 03:04 | | |
| Colts timeout.4th 03:04 | | |
| Darrynton Evans rush to the left for 5 yards to the Ind48. Tackled by Aaron Maddox.4th 03:11 | | |
| Colts timeout.4th 03:11 | | |
| Darrynton Evans rush to the middle for 5 yards to the Buf47. Tackled by Khalid Kareem and Titus Leo.4th 03:19 | | |
| Matt Barkley pass to the right to Joel Wilson for 3 yards to the Buf42. Tackled by Grant Stuard.4th 03:59 | | |
| Lucas Havrisik kicks off to the Buf-3. Darrynton Evans return for 42 yards to Buf39. Tackled by Aaron Maddox.4th 04:07 | | |
| Sam Ehlinger 2 pt conversion pass intended for Michael Jacobson is NO GOOD.4th 04:07 | | |
| Jason Huntley rush to the middle for 3 yards for a TOUCHDOWN.4th 04:13 | 6 | |
| Penalty: Pass Interference on Bills (Alex Austin) 22 yards.4th 04:19 | | |
| Sam Ehlinger pass to the left to Malik Turner for 30 yards to the Buf25. Tackled by Zayne Anderson.4th 04:53 | | |
| Sam Ehlinger pass to the left to Malik Turner for 6 yards to the Ind45. Tackled by Kyron Brown.4th 05:18 | | |
| Sam Ehlinger pass to the left to Malik Turner for 3 yards to the Ind39. Tackled by Kyron Brown.4th 05:53 | | |
| Jason Huntley rush to the left for 3 yards to the Ind36. Tackled by Jared Mayden and Travin Howard.4th 06:29 | | |
| Sam Ehlinger incomplete pass to the left.4th 06:38 | | |
| Sam Ehlinger pass to the left to Malik Turner for 9 yards to the Ind33. Tackled by Zayne Anderson.4th 07:21 | | |
| Tyler Bass kicks off to the Ind3. Josh Downs return for 21 yards to Ind24. Tackled by Zayne Anderson.4th 07:26 | | |
| Tyler Bass extra point is NO GOOD.4th 07:26 | | |
| Matt Barkley pass to the left to Dezmon Patmon for 13 yards for a TOUCHDOWN.4th 07:32 | | 6 |
| Matt Barkley pass to the left to Andy Isabella for 5 yards to the Ind13. Tackled by Cam McGrone.4th 08:08 | | |
| Jordan Mims rush to the right for 2 yards to the Ind18. Tackled by Kevin Toliver II.4th 08:50 | | |
| Penalty: Pass Interference on Colts (Aaron Maddox) 25 yards.4th 08:58 | | |
| Matt Barkley pass to the right to Dezmon Patmon for 6 yards to the Ind45. Tackled by Kevin Toliver II.4th 09:32 | | |
| Darrynton Evans rush to the right for 6 yards to the Buf49. Tackled by Titus Leo.4th 10:10 | | |
| Matt Barkley pass to the right to Dezmon Patmon for 16 yards to the Buf43. Tackled by Kevin Toliver II.4th 10:53 | | |
| Darrynton Evans rush to the left for 1 yard to the Buf27. Tackled by Cam McGrone.4th 11:26 | | |
| Kenyan Drake rush to the middle for no gain to the Buf26. Tackled by Ja'Marcus Ingram.4th 11:31 | | |
| Kenyan Drake rush to the right for 1 yard to the Buf26. Tackled by Baylon Spector and Shane Ray.4th 12:09 | | |
| Kenyan Drake rush to the left for 2 yards to the Buf27. Tackled by Ja'Marcus Ingram.4th 12:34 | | |
| Sam Ehlinger pass to the right to Amari Rodgers for 6 yards to the Buf29. Tackled by Alex Austin.4th 13:07 | | |
| Sam Ehlinger rush to the middle for 7 yards to the Buf35. Tackled by Kameron Cline.4th 13:42 | | |
| Kenyan Drake rush to the left for 5 yards to the Buf42. Tackled by Eli Ankou.4th 14:13 | | |
| Matt Barkley pass to the middle to Jace Sternberger for 17 yards to the Buf47. Tackled by Grant Stuard and Henry Black. FUMBLE, recovered by Ind (Donavan Mutin).4th 14:22 | | |
| Matt Barkley sacked at Buf30 for a loss of 8 yards by Khalid Kareem.4th 15:00 | | |
| Jordan Mims rush to the left for 4 yards to the Buf38. Tackled by Eric Johnson II and Khalid Kareem.3rd 00:21 | | |
| Matt Barkley pass to the right to KeeSean Johnson for 21 yards to the Buf34. Tackled by Grant Stuard and Isaac Taylor-Stuart.3rd 01:06 | | |
| Penalty: Illegal Formation on Bills -5 yards.3rd 01:28 | | |
| Rigoberto Sanchez punts for 48 yards to Buf13. Andy Isabella return for 5 yards to Buf18. Tackled by Donavan Mutin and Segun Olubi.3rd 01:42 | | |
| Penalty: Too Many Men on Field on Bills 5 yards.3rd 01:52 | | |
| Sam Ehlinger pass to the middle to Jake Funk for 2 yards to the Ind34. Tackled by Kendal Vickers.3rd 02:28 | | |
| Sam Ehlinger sacked at Ind32 for a loss of 7 yards by Kameron Cline and DJ Dale.3rd 02:53 | | |
| Kenyan Drake rush to the left for 2 yards to the Ind39. Tackled by Travin Howard and Cortez Broughton.3rd 03:36 | | |
| Sam Ehlinger pass to the left to Amari Rodgers for 11 yards to the Ind37. Tackled by Dean Marlowe and Alex Austin.3rd 04:16 | | |
| Sam Ehlinger pass to the right to Breshad Perriman for 5 yards to the Ind26. Tackled by Zayne Anderson.3rd 04:51 | | |
| Sam Ehlinger rush to the right for 3 yards to the Ind21. Tackled by Eli Ankou.3rd 05:32 | | |
| Jake Funk rush to the right for 3 yards to the Ind18. Tackled by Kendal Vickers.3rd 06:06 | | |
| Tyler Bass kicks off to the Ind-2. Josh Downs return for 17 yards to Ind15. Tackled by Shane Ray and Zayne Anderson.3rd 06:11 | | |
| Tyler Bass extra point is GOOD.3rd 06:11 | | 1 |
| Matt Barkley pass to the left to Tyrell Shavers for 22 yards for a TOUCHDOWN.3rd 06:17 | | 6 |
| Darrynton Evans rush to the left for a loss of 2 yards to the Ind22. Tackled by Khalid Kareem.3rd 06:57 | | |
| Matt Barkley pass to the middle to KeeSean Johnson for 12 yards to the Ind20. Tackled by Grant Stuard.3rd 07:32 | | |
| Darrynton Evans rush to the left for 3 yards to the Ind32. Tackled by Henry Black and Chris Lammons.3rd 08:09 | | |
| Penalty: Offside on Colts (Dayo Odeyingbo) 5 yards.3rd 08:35 | | |
| Jordan Mims rush to the right for 3 yards to the Ind40. Tackled by Grant Stuard.3rd 09:10 | | |
| Matt Barkley pass to the middle to Andy Isabella for 7 yards to the Ind43. Tackled by Henry Black.3rd 09:47 | | |
| Matt Barkley pass to the left to Jordan Mims for 5 yards to the Buf50. Tackled by Segun Olubi and Grant Stuard.3rd 10:32 | | |
| Matt Barkley incomplete pass to the left intended for Tyrell Shavers.3rd 10:36 | | |
| Matt Barkley pass to the left to Marcell Ateman for 20 yards to the Buf45. Tackled by Cam McGrone.3rd 11:07 | | |
| Matt Barkley pass to the middle to KeeSean Johnson for 9 yards to the Buf25. Tackled by Kevin Toliver II.3rd 11:45 | | |
| Jordan Mims rush to the right for a loss of 1 yard to the Buf16. Tackled by Grant Stuard and Titus Leo.3rd 12:25 | | |
| Lucas Havrisik kicks off to the Buf1. Andy Isabella return for 16 yards to Buf17. Tackled by Henry Black.3rd 12:30 | | |
| Lucas Havrisik extra point is NO GOOD.3rd 12:30 | | |
| Kyle Allen pass intended for Tyrell Shavers INTERCEPTED by Darius Rush and returned for 52 yards for a TOUCHDOWN.3rd 12:40 | 6 | |
| Jordan Mims rush to the left for 2 yards to the Ind44. Tackled by Grant Stuard.3rd 13:17 | | |
| Kyle Allen pass to the right to Jordan Mims for 25 yards to the Ind46. Tackled by Cam McGrone.3rd 13:50 | | |
| Kyle Allen pass to the right to Marcell Ateman for 21 yards to the Buf29. Tackled by Kevin Toliver II.3rd 14:08 | | |
| Kyle Allen incomplete pass to the right intended for Tyrell Shavers defensed by Kevin Toliver II.3rd 14:13 | | |
| Kyle Allen sacked at Buf8 for a loss of 10 yards by Dayo Odeyingbo.3rd 14:54 | | |
| Lucas Havrisik kicks off to the Buf4. Andy Isabella return for 14 yards to Buf18. Tackled by Vyncint Smith and Henry Black.3rd 15:00 | | |
| Matt Gay kicks off to the Buf5. Andy Isabella return for 18 yards to Buf23. Tackled by Grant Stuard and Cam McGrone.2nd 00:03 | | |
| Matt Gay extra point is GOOD.2nd 00:03 | 1 | |
| Jake Funk rush to the right for 1 yard for a TOUCHDOWN.2nd 00:05 | 6 | |
| Colts timeout.2nd 00:05 | | |
| Jake Funk rush to the middle for no gain to the Buf1. Tackled by Dorian Williams and Kaiir Elam.2nd 00:10 | | |
| Penalty: Pass Interference on Bills (Siran Neal) 1 yard.2nd 00:11 | | |
| Gardner Minshew II pass to the middle to Pharaoh Brown for 10 yards to the Buf2. Tackled by Dorian Williams and Dean Marlowe.2nd 00:32 | | |
| Colts timeout.2nd 00:32 | | |
| Jake Funk rush to the left for 6 yards to the Buf12. Tackled by Cortez Broughton and A.J. Klein.2nd 00:37 | | |
| Gardner Minshew II pass to the middle to Josh Downs for 18 yards to the Buf18. Tackled by Siran Neal.2nd 01:04 | | |
| Gardner Minshew II pass to the middle to Jake Funk for 8 yards to the Buf36. Tackled by Dorian Williams and Siran Neal.2nd 01:31 | | |
| Gardner Minshew II pass to the left to Ashton Dulin for 7 yards to the Buf44. Tackled by Dorian Williams.2nd 01:53 | | |
| Gardner Minshew II pass to the left to Mike Strachan for 18 yards to the Ind49. Tackled by Christian Benford.2nd 02:00 | | |
| Jake Funk rush to the middle for 2 yards to the Ind31. Tackled by Shane Ray.2nd 02:06 | | |
| Gardner Minshew II pass to the right to Josh Downs for 11 yards to the Ind29. Tackled by Jared Mayden.2nd 02:50 | | |
| Jake Funk rush to the middle for no gain to the Ind18. Tackled by Cortez Broughton and Eli Ankou.2nd 03:29 | | |
| Penalty: Holding (Return) on Bills (Cortez Broughton) 5 yards.2nd 03:48 | | |
| Jake Funk rush to the right for 1 yard to the Ind13. Tackled by Boogie Basham and Jared Mayden.2nd 04:25 | | |
| Sam Martin punts for 32 yards to Ind12. No return.2nd 04:33 | | |
| Kyle Allen incomplete pass to the middle intended for Quintin Morris.2nd 04:39 | | |
| Kyle Allen sacked at Ind44 for a loss of 10 yards by Al-Quadin Muhammad.2nd 05:22 | | |
| Latavius Murray rush to the middle for 4 yards to the Ind34. Tackled by Nick Cross.2nd 05:53 | | |
| Kyle Allen pass to the middle to Andy Isabella for 30 yards to the Ind38. Tackled by Henry Black and Nick Cross.2nd 06:39 | | |
| Kyle Allen pass to the left to Latavius Murray for 7 yards to the Buf32. Tackled by Segun Olubi.2nd 07:19 | | |
| Rigoberto Sanchez punts for 65 yards to Buf20. Deonte Harty return for 5 yards to Buf25. Tackled by Grant Stuard.2nd 07:32 | | |
| Evan Hull rush to the left for 1 yard to the Ind15. Tackled by Poona Ford.2nd 08:10 | | |
| Gardner Minshew II sacked at Ind14 for a loss of 6 yards by Boogie Basham.2nd 08:48 | | |
| Gardner Minshew II sacked at Ind20 for a loss of 5 yards by Tim Settle.2nd 09:28 | | |
| Tyler Bass kicks off to the Ind10. Josh Downs return for 15 yards to Ind25. Tackled by Marcell Ateman.2nd 09:34 | | |
| Tyler Bass 40 yard field goal attempt is GOOD.2nd 09:38 | | 3 |
| Kyle Allen incomplete pass to the left intended for Khalil Shakir.2nd 09:43 | | |
| Kyle Allen pass to the right to Khalil Shakir for 5 yards to the Ind22. Tackled by Jaylon Jones.2nd 10:27 | | |
| Kyle Allen incomplete pass to the left intended for Deonte Harty.2nd 10:32 | | |
| Kyle Allen rush to the right for 5 yards to the Ind27. Tackled by JuJu Brents.2nd 11:08 | | |
| Latavius Murray rush to the left for 1 yard to the Ind32. Tackled by Segun Olubi.2nd 11:43 | | |
| Latavius Murray rush to the middle for 2 yards to the Ind33. Tackled by Grant Stuard.2nd 12:21 | | |
| Latavius Murray rush to the middle for 5 yards to the Ind35. Tackled by E.J. Speed.2nd 12:59 | | |
| Kyle Allen pass to the left to Khalil Shakir for 20 yards to the Ind40. Tackled by Segun Olubi.2nd 13:37 | | |
| Kyle Allen incomplete pass to the right intended for Khalil Shakir defensed by McTelvin Agim.2nd 13:43 | | |
| Kyle Allen pass to the right to Latavius Murray for a loss of 2 yards to the Buf40. Tackled by E.J. Speed.2nd 14:27 | | |
| Kyle Allen pass to the middle to Latavius Murray for 16 yards to the Buf42. Tackled by Segun Olubi.2nd 15:00 | | |
| Latavius Murray rush to the middle for 6 yards to the Buf26. Tackled by Chris Lammons.1st 00:10 | | |
| 28 yard field goal attempt by Matt Gay is NO GOOD.1st 00:13 | | |
| Anthony Richardson pass to the left to Evan Hull for 8 yards to the Buf10. Tackled by Dorian Williams.1st 00:59 | | |
| Anthony Richardson incomplete pass to the right intended for Michael Pittman Jr..1st 01:02 | | |
| Evan Hull rush to the right for 2 yards to the Buf18. Tackled by Poona Ford and Ja'Marcus Ingram.1st 01:27 | | |
| Anthony Richardson rush to the left for 2 yards to the Buf10. Tackled by Kaiir Elam. Penalty: Holding on Colts (Pharaoh Brown) -10 yards.1st 01:53 | | |
| Deon Jackson rush to the left for 6 yards to the Buf12. Tackled by Tyrel Dodson and Poona Ford.1st 02:18 | | |
| Deon Jackson rush to the middle for 5 yards to the Buf18. Tackled by Taylor Rapp.1st 02:40 | | |
| Anthony Richardson pass to the right to Isaiah McKenzie for 11 yards to the Buf23. Tackled by Christian Benford.1st 03:08 | | |
| Anthony Richardson incomplete pass to the right intended for Alec Pierce defensed by Siran Neal.1st 03:15 | | |
| Penalty: Pass Interference on Bills (Kaiir Elam) 11 yards.1st 03:20 | | |
| Anthony Richardson pass to the middle to Kylen Granson for 20 yards to the Buf45. Tackled by Siran Neal and Taylor Rapp.1st 03:46 | | |
| Anthony Richardson pass to the right to Evan Hull for 10 yards to the Ind35. Tackled by Dorian Williams.1st 04:16 | | |
| Evan Hull rush to the left for 4 yards to the Ind25. Tackled by Damar Hamlin.1st 04:52 | | |
| Deon Jackson rush to the left for 9 yards to the Ind21. Tackled by Damar Hamlin and Dorian Williams.1st 05:33 | | |
| Anthony Richardson incomplete pass to the left intended for Kylen Granson.1st 05:37 | | |
| Penalty: Offside on Bills (Ed Oliver) 5 yards.1st 06:01 | | |
| Sam Martin punts for 46 yards to Ind7. No return.1st 06:12 | | |
| Kyle Allen incomplete pass to the right intended for Trent Sherfield defensed by Darrell Baker Jr..1st 06:16 | | |
| James Cook rush to the middle for 7 yards to the Buf47. Tackled by Zaire Franklin.1st 06:59 | | |
| James Cook rush to the middle for no gain to the Buf40. Tackled by Trevor Denbow and Samson Ebukam.1st 07:35 | | |
| Evan Hull rush to the right for no gain to the Buf40. Tackled by Damar Hamlin.1st 07:42 | | |
| Evan Hull rush to the middle for 1 yard to the Buf40. Tackled by Boogie Basham.1st 08:25 | | |
| Deon Jackson rush to the middle for 2 yards to the Buf41. Tackled by Eli Ankou and Tyrel Dodson.1st 09:02 | | |
| Deon Jackson rush to the right for 6 yards to the Buf43. Tackled by Christian Benford.1st 09:29 | | |
| Penalty: Offside on Bills (Greg Rousseau) 5 yards.1st 09:48 | | |
| Anthony Richardson incomplete pass to the left intended for Michael Pittman Jr..1st 09:54 | | |
| Deon Jackson rush to the middle for 7 yards to the Ind46. Tackled by Siran Neal.1st 10:33 | | |
| Anthony Richardson pass to the right to Michael Pittman Jr. for 9 yards to the Ind39. Tackled by Jordan Poyer.1st 10:59 | | |
| Anthony Richardson rush to the right for 5 yards to the Ind30. Tackled by Kaiir Elam.1st 11:32 | | |
| Tyler Bass kicks off to the Ind5. Josh Downs return for 20 yards to Ind25. Tackled by Alex Austin.1st 11:38 | | |
| Tyler Bass extra point is GOOD.1st 11:38 | | 1 |
| James Cook rush to the left for 8 yards for a TOUCHDOWN.1st 11:43 | | 6 |
| James Cook rush to the middle for 5 yards to the Ind8. Tackled by Zaire Franklin and Darrell Baker Jr..1st 12:49 | | |
| Anthony Richardson pass intended for Isaiah McKenzie INTERCEPTED by Dane Jackson and returned for 20 yards. Tackled by Evan Hull.1st 12:58 | | |
| Anthony Richardson pass to the left to Isaiah McKenzie for 4 yards to the Ind24. Tackled by Dane Jackson and Micah Hyde.1st 13:33 | | |
| Evan Hull rush to the right for 5 yards to the Ind20. Tackled by Matt Milano.1st 13:56 | | |
| Anthony Richardson pass to the left to Isaiah McKenzie for 5 yards to the Ind15. Tackled by Micah Hyde and Matt Milano.1st 14:22 | | |
| Evan Hull rush to the right for 2 yards to the Ind10. Tackled by Greg Rousseau.1st 14:56 | | |
| Tyler Bass kicks off to the Ind-6. Isaiah McKenzie return for 22 yards to Ind16. Tackled by Quintin Morris and Trent Sherfield. Penalty: Holding on Colts (Segun Olubi) -8 yards.1st 15:00 | | |
